AU2001254711A1 - Sustained release vitamin composition - Google Patents
Sustained release vitamin compositionInfo
- Publication number
- AU2001254711A1 AU2001254711A1 AU2001254711A AU5471101A AU2001254711A1 AU 2001254711 A1 AU2001254711 A1 AU 2001254711A1 AU 2001254711 A AU2001254711 A AU 2001254711A AU 5471101 A AU5471101 A AU 5471101A AU 2001254711 A1 AU2001254711 A1 AU 2001254711A1
- Authority
- AU
- Australia
- Prior art keywords
- sustained release
- release
- medicament
- inner core
- release vitamin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 229940088594 vitamin Drugs 0.000 title abstract 3
- 229930003231 vitamin Natural products 0.000 title abstract 3
- 235000013343 vitamin Nutrition 0.000 title abstract 3
- 239000011782 vitamin Substances 0.000 title abstract 3
- 150000003722 vitamin derivatives Chemical class 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 238000013268 sustained release Methods 0.000 title abstract 2
- 239000012730 sustained-release form Substances 0.000 title abstract 2
- 239000003814 drug Substances 0.000 abstract 3
- 239000011248 coating agent Substances 0.000 abstract 2
- 238000000576 coating method Methods 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 238000013270 controlled release Methods 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Food Science & Technology (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Confectionery (AREA)
Abstract
A therapeutic formulation in the form of a beadlet, suitable for oral administration and adapted to provide immediate and sustained release of therapeutic material. Each beadlet comprises an extruded-spheronized inner core containing at least one medicament e.g. a slow release vitamin, an outer layer containing at least one medicament e.g. a fast release vitamin and a controlled release coating between the inner core and the outer layer which coating controls the release of the inner core medicament.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0007419.5A GB0007419D0 (en) | 2000-03-27 | 2000-03-27 | Composition |
GB0007419 | 2000-03-27 | ||
PCT/EP2001/003192 WO2001072286A1 (en) | 2000-03-27 | 2001-03-21 | Sustained release vitamin composition |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001254711A1 true AU2001254711A1 (en) | 2001-10-08 |
Family
ID=9888515
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001254711A Abandoned AU2001254711A1 (en) | 2000-03-27 | 2001-03-21 | Sustained release vitamin composition |
Country Status (15)
Country | Link |
---|---|
US (1) | US7422758B2 (en) |
EP (1) | EP1267844B2 (en) |
KR (1) | KR100824104B1 (en) |
AT (1) | ATE381926T2 (en) |
AU (1) | AU2001254711A1 (en) |
BR (1) | BRPI0109575B8 (en) |
CZ (1) | CZ304818B6 (en) |
DE (1) | DE60132077T3 (en) |
ES (1) | ES2298231T5 (en) |
GB (1) | GB0007419D0 (en) |
HU (1) | HU230771B1 (en) |
MX (1) | MXPA02009547A (en) |
PL (1) | PL202684B1 (en) |
RU (1) | RU2248200C2 (en) |
WO (1) | WO2001072286A1 (en) |
Families Citing this family (59)
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US7560123B2 (en) | 2004-08-12 | 2009-07-14 | Everett Laboratories, Inc. | Compositions and methods for nutrition supplementation |
US7985422B2 (en) | 2002-08-05 | 2011-07-26 | Torrent Pharmaceuticals Limited | Dosage form |
TWI319713B (en) * | 2002-10-25 | 2010-01-21 | Sustained-release tramadol formulations with 24-hour efficacy | |
US8487002B2 (en) * | 2002-10-25 | 2013-07-16 | Paladin Labs Inc. | Controlled-release compositions |
US8617617B2 (en) | 2002-12-10 | 2013-12-31 | Everett Laboratories, Inc. | Methods and kits for co-administration of nutritional supplements |
US6814983B2 (en) * | 2002-12-10 | 2004-11-09 | Everett Laboratories, Inc. | Compositions and methods for nutrition supplementation |
US20060172006A1 (en) * | 2003-10-10 | 2006-08-03 | Vincent Lenaerts | Sustained-release tramadol formulations with 24-hour clinical efficacy |
US7785619B2 (en) * | 2004-04-08 | 2010-08-31 | Micro Nutrient, Llc | Pharmanutrient composition(s) and system(s) for individualized, responsive dosing regimens |
WO2005097085A1 (en) * | 2004-04-08 | 2005-10-20 | Micro Nutrient, Llc | Nutrient system for individualized responsive dosing regimens |
US8101587B2 (en) | 2004-08-12 | 2012-01-24 | Everett Laboratories, Inc. | Kits for nutrition supplementation |
DE102005011029A1 (en) * | 2005-03-08 | 2006-09-14 | Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh | Composition for peroral application with controlled release of active substances |
GB0507167D0 (en) * | 2005-04-08 | 2005-05-18 | Glaxosmithkline Consumer Healt | Composition |
PL1931346T3 (en) * | 2005-09-09 | 2013-01-31 | Angelini Labopharm Llc | Trazodone composition for once a day administration |
US20070128272A1 (en) * | 2005-12-07 | 2007-06-07 | Zerbe Horst G | Multi-vitamin and mineral supplement |
CA2882048C (en) | 2006-02-03 | 2020-03-24 | Proventiv Therapeutics, Llc | Treating vitamin d insufficiency and deficiency with 25-hydroxyvitamin d2 and 25-hydroxyvitamin d3 |
PL2679228T3 (en) | 2006-06-21 | 2018-07-31 | Opko Ireland Global Holdings, Ltd. | Therapy using vitamin D repletion agent and vitamin D hormone replacement agent |
US8491937B2 (en) * | 2007-02-15 | 2013-07-23 | Wyeth Llc | Stability in vitamin and mineral supplements |
US20100255118A1 (en) * | 2007-03-12 | 2010-10-07 | Kanzer Steve H | Oral zinc medicants useful for safely lowering free copper absorption and free copper levels |
ES2403107T3 (en) * | 2007-04-25 | 2013-05-14 | Cytochroma Inc. | Vitamin D insufficiency and deficiency treatment method |
EP3542792B1 (en) | 2007-04-25 | 2023-06-28 | EirGen Pharma Ltd. | Controlled release 25-hydroxyvitamin d |
WO2008134523A1 (en) | 2007-04-25 | 2008-11-06 | Proventiv Therapeutics, Llc | Method of safely and effectively treating and preventing secondary hyperparathyroidism in chronic kidney disease |
DE102007027435A1 (en) * | 2007-06-14 | 2008-12-18 | X-Fab Semiconductor Foundries Ag | Method and device for structured layer deposition on processed microsystem technology wafers |
IL187159A0 (en) * | 2007-07-03 | 2009-02-11 | Gur Megiddo | Use of metadoxine in relief of alcohol intoxication |
JP2010535767A (en) * | 2007-08-03 | 2010-11-25 | シャクリー コーポレーション | Nutritional dosage unit |
US9763989B2 (en) | 2007-08-03 | 2017-09-19 | Shaklee Corporation | Nutritional supplement system |
US20090181084A1 (en) * | 2008-01-15 | 2009-07-16 | Ta-Ping Liao | Oral fast-disintegrating tablet including particles of slowly-releaseable ascorbic acid |
US8962239B2 (en) | 2008-04-02 | 2015-02-24 | Opko Renal, Llc | Methods useful for vitamin D deficiency and related disorders |
WO2010013242A1 (en) | 2008-07-29 | 2010-02-04 | Alcobra Ltd. | Substituted pyridoxine-lactam carboxylate salts |
US20120065221A1 (en) | 2009-02-26 | 2012-03-15 | Theraquest Biosciences, Inc. | Extended Release Oral Pharmaceutical Compositions of 3-Hydroxy-N-Methylmorphinan and Method of Use |
EA023758B1 (en) * | 2009-06-25 | 2016-07-29 | Алкобра Лтд. | Use of metadoxine for treating attention deficit/hyperactivity disorder (adhd/add) |
US8545892B2 (en) * | 2009-06-26 | 2013-10-01 | Nano Pharmaceutical Laboratories, Llc | Sustained release beads and suspensions including the same for sustained delivery of active ingredients |
US20110091618A1 (en) * | 2009-10-16 | 2011-04-21 | Frito-Lay North America, Inc. | Method for preventing oxidation and off flavors in high carotenoid foods |
CA2775246C (en) * | 2009-10-20 | 2020-03-24 | Herbonis Ag | Composition comprising solanum glaucophyllum for preventing and/or treating hypocalcaemia and for stabilizing blood calcium levels |
HUE048464T2 (en) | 2010-03-29 | 2020-07-28 | Opko Ireland Global Holdings Ltd | Methods and compositions for reducing parathyroid levels |
US8183227B1 (en) | 2011-07-07 | 2012-05-22 | Chemo S. A. France | Compositions, kits and methods for nutrition supplementation |
US8168611B1 (en) | 2011-09-29 | 2012-05-01 | Chemo S.A. France | Compositions, kits and methods for nutrition supplementation |
DE102011122250A1 (en) | 2011-10-24 | 2013-04-25 | Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh | Multiphase system, useful e.g. to treat vitamin deficiency, comprises two different phases/layers comprising first phase/layer of active component comprising iron(II) compound, and second phase/layer of active component comprising vitamin |
US20150351438A1 (en) * | 2013-01-29 | 2015-12-10 | Otc Nutrition Llc | Micronutrient Fortification Delivery |
KR101847947B1 (en) | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | Stabilized modified release vitamin d formulation |
EP3007680B1 (en) * | 2013-06-14 | 2020-02-19 | CONARIS research institute AG | Extended release nicotinamide formulation |
CA2957240A1 (en) | 2014-08-07 | 2016-02-11 | Opko Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin d |
TW201618783A (en) | 2014-08-07 | 2016-06-01 | 艾森塔製藥公司 | Methods of treating cancers, immune and autoimmune diseases, and inflammatory diseases based on BTK occupancy and BTK resynthesis rate |
KR20160050405A (en) * | 2014-10-29 | 2016-05-11 | 가톨릭대학교 산학협력단 | Drug-eluting balloon including fat-soluble additive and method thereof |
MX2017008979A (en) * | 2015-01-07 | 2018-03-02 | Corr Jensen Inc | Compositions and methods for enhancing athletic performance. |
EP3244881A4 (en) * | 2015-01-12 | 2018-08-15 | Nano Pharmaceutical Laboratories LLC | Layered sustained-release microbeads and methods of making the same |
CA3013795A1 (en) * | 2016-02-17 | 2017-08-24 | Corr-Jensen Inc. | Time release vitamins and minerals in edible oils |
JP7032322B2 (en) | 2016-03-28 | 2022-03-08 | オプコ アイルランド グローバル ホールディングス リミテッド | Vitamin D treatment |
JP7021108B2 (en) | 2016-04-19 | 2022-02-16 | コナリス リサーチ インスティテュート アクチェンゲゼルシャフト | Oral pharmaceutical composition of nicotinamide |
WO2017185038A1 (en) | 2016-04-22 | 2017-10-26 | Receptor Life Sciences | Fast-acting plant-based medicinal compounds and nutritional supplements |
EA201892396A1 (en) | 2016-12-02 | 2019-04-30 | Ресептор Лайф Сайенсиз, Инк. | QUICKLY PRODUCTIVE PLANT MEDICINES AND BIOLOGICALLY ACTIVE ADDITIVES |
TR201702630A2 (en) | 2017-02-22 | 2018-09-21 | Montero Gida Sanayi Ve Ticaret Anonim Sirketi | ORAL PHARMACEUTICAL COMPOSITIONS CONTAINING ALPHA LIPOIC ACID AND WATER SOLUBLE VITAMINS |
CN107375711B (en) * | 2017-08-25 | 2020-11-03 | 贵州盛茂白芨开发有限公司 | Bletilla striata buccal tablet |
DE202018101110U1 (en) | 2018-02-28 | 2019-06-03 | Omnivision Gmbh | Easy-to-use AREDS2 medication |
CN113747886A (en) * | 2019-04-30 | 2021-12-03 | 帝斯曼知识产权资产管理有限公司 | Novel specific water-soluble vitamin delivery system |
AR118962A1 (en) * | 2019-05-22 | 2021-11-10 | Bayer Consumer Care Ag | VITAMIN AND MINERALS SOFT GELATIN CAPSULE PREPARATIONS COMPRISING VITAMIN C IN THE FORM OF AN ASCORBATE SALT |
CN114867363A (en) * | 2019-12-10 | 2022-08-05 | 比利时胶囊公司 | Granules comprising a lipid matrix core and an active ingredient |
TR202014936A2 (en) | 2020-09-21 | 2022-03-21 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | A double-layer pharmaceutical tablet containing alpha lipoic acid and at least one vitamin b |
WO2023173111A2 (en) * | 2022-03-11 | 2023-09-14 | Balchem Corporation | Intra-dosage form coatings and applications thereof |
CN115569118B (en) * | 2022-10-27 | 2023-05-05 | 泓博元生命科技(深圳)有限公司 | Microsphere preparation for efficiently improving NAD+ level and preparation process thereof |
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GB800973A (en) † | 1954-08-13 | 1958-09-03 | Sterling Drug Inc | Improvements in or relating to pills or tablets |
US2928770A (en) † | 1958-11-28 | 1960-03-15 | Frank M Bardani | Sustained action pill |
US3577512A (en) † | 1968-10-11 | 1971-05-04 | Nat Patent Dev Corp | Sustained release tablets |
US3939259A (en) | 1974-05-24 | 1976-02-17 | Anthony Pescetti | Coating composition and therapeutic preparation incorporating same |
DE3403329A1 (en) † | 1984-02-01 | 1985-08-01 | Horst Dr. 4019 Monheim Zerbe | PHARMACEUTICAL PRODUCT IN THE FORM OF PELLETS WITH CONTINUOUS, DELAYED DELIVERY OF ACTIVE SUBSTANCES |
EP0208362A1 (en) * | 1985-06-28 | 1987-01-14 | The Procter & Gamble Company | Dietary supplements containing iron and enterically coated calcium |
JPS62103012A (en) * | 1985-10-23 | 1987-05-13 | Eisai Co Ltd | Multi-layered granule |
AU591248B2 (en) † | 1986-03-27 | 1989-11-30 | Kinaform Technology, Inc. | Sustained-release pharaceutical preparation |
US4752479A (en) † | 1986-05-27 | 1988-06-21 | Ciba-Geigy Corporaton | Multi vitamin and mineral dietary supplement with controlled release bioavailable iron |
US4808413A (en) * | 1987-04-28 | 1989-02-28 | E. R. Squibb & Sons, Inc. | Pharmaceutical compositions in the form of beadlets and method |
GB8711256D0 (en) * | 1987-05-13 | 1987-06-17 | Unilever Plc | Protection |
US5049394A (en) * | 1987-09-11 | 1991-09-17 | E. R. Squibb & Sons, Inc. | Pharmaceutical composition containing high drug load and method for preparing same |
JP2643222B2 (en) | 1988-02-03 | 1997-08-20 | エーザイ株式会社 | Multi-layer granules |
US5026559A (en) † | 1989-04-03 | 1991-06-25 | Kinaform Technology, Inc. | Sustained-release pharmaceutical preparation |
US5158777A (en) * | 1990-02-16 | 1992-10-27 | E. R. Squibb & Sons, Inc. | Captopril formulation providing increased duration of activity |
DE4112464A1 (en) † | 1991-04-17 | 1992-10-22 | Henkel Kgaa | IMPROVED RETARD SYSTEMS FOR THE PERIODIC RELEASE OF MEDICAL AND / OR BIOLOGICAL MATERIALS FROM A DEPOT CARRIER MATERIAL |
GB9117361D0 (en) † | 1991-08-12 | 1991-09-25 | Euro Celtique Sa | Oral dosage form |
US5472712A (en) † | 1991-12-24 | 1995-12-05 | Euroceltique, S.A. | Controlled-release formulations coated with aqueous dispersions of ethylcellulose |
US5869084A (en) * | 1994-06-20 | 1999-02-09 | K-V Pharmaceuticals Co. | Multi-vitamin and mineral supplements for women |
DE19718012C1 (en) † | 1997-04-29 | 1998-10-08 | Jenapharm Gmbh | Process for the production of orally applicable solid pharmaceutical forms with controlled release of active substances |
WO1998053802A1 (en) * | 1997-05-30 | 1998-12-03 | Laboratorios Phoenix U.S.A., Inc. | Multi-layered osmotic device |
US6419960B1 (en) * | 1998-12-17 | 2002-07-16 | Euro-Celtique S.A. | Controlled release formulations having rapid onset and rapid decline of effective plasma drug concentrations |
-
2000
- 2000-03-27 GB GBGB0007419.5A patent/GB0007419D0/en not_active Ceased
-
2001
- 2001-03-21 HU HU0300373A patent/HU230771B1/en unknown
- 2001-03-21 DE DE60132077.8T patent/DE60132077T3/en not_active Expired - Lifetime
- 2001-03-21 WO PCT/EP2001/003192 patent/WO2001072286A1/en active IP Right Grant
- 2001-03-21 ES ES01927763.1T patent/ES2298231T5/en not_active Expired - Lifetime
- 2001-03-21 PL PL359663A patent/PL202684B1/en unknown
- 2001-03-21 BR BRPI0109575A patent/BRPI0109575B8/en not_active IP Right Cessation
- 2001-03-21 CZ CZ2002-3247A patent/CZ304818B6/en not_active IP Right Cessation
- 2001-03-21 EP EP01927763.1A patent/EP1267844B2/en not_active Expired - Lifetime
- 2001-03-21 RU RU2002128739/15A patent/RU2248200C2/en active
- 2001-03-21 US US10/239,808 patent/US7422758B2/en not_active Expired - Lifetime
- 2001-03-21 AT AT01927763T patent/ATE381926T2/en active
- 2001-03-21 AU AU2001254711A patent/AU2001254711A1/en not_active Abandoned
- 2001-03-21 MX MXPA02009547A patent/MXPA02009547A/en active IP Right Grant
- 2001-03-21 KR KR1020027012706A patent/KR100824104B1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
BRPI0109575B8 (en) | 2021-05-25 |
PL359663A1 (en) | 2004-08-23 |
CZ304818B6 (en) | 2014-11-19 |
EP1267844A1 (en) | 2003-01-02 |
HU230771B1 (en) | 2018-03-28 |
US20030148992A1 (en) | 2003-08-07 |
EP1267844B1 (en) | 2007-12-26 |
RU2248200C2 (en) | 2005-03-20 |
HUP0300373A2 (en) | 2003-06-28 |
ATE381926T2 (en) | 2008-01-15 |
CZ20023247A3 (en) | 2003-04-16 |
EP1267844B2 (en) | 2016-04-13 |
KR20030020267A (en) | 2003-03-08 |
KR100824104B1 (en) | 2008-04-21 |
BRPI0109575B1 (en) | 2016-06-07 |
BR0109575A (en) | 2003-04-15 |
ES2298231T3 (en) | 2008-05-16 |
GB0007419D0 (en) | 2000-05-17 |
HUP0300373A3 (en) | 2005-03-29 |
DE60132077T2 (en) | 2008-12-18 |
US7422758B2 (en) | 2008-09-09 |
PL202684B1 (en) | 2009-07-31 |
MXPA02009547A (en) | 2004-07-30 |
DE60132077T3 (en) | 2016-07-14 |
ES2298231T5 (en) | 2016-06-08 |
DE60132077D1 (en) | 2008-02-07 |
WO2001072286A1 (en) | 2001-10-04 |
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