EA032906B1 - Твердая лекарственная форма с контролируемым высвобождением и способы ее получения и применения - Google Patents

Твердая лекарственная форма с контролируемым высвобождением и способы ее получения и применения

Info

Publication number
EA032906B1
EA032906B1 EA201300747A EA201300747A EA032906B1 EA 032906 B1 EA032906 B1 EA 032906B1 EA 201300747 A EA201300747 A EA 201300747A EA 201300747 A EA201300747 A EA 201300747A EA 032906 B1 EA032906 B1 EA 032906B1
Authority
EA
Eurasian Patent Office
Prior art keywords
opioid analgesic
dosage form
controlled release
core
release dosage
Prior art date
Application number
EA201300747A
Other languages
English (en)
Other versions
EA201300747A1 (ru
Inventor
Хайюн Хью Хуан
Original Assignee
Пэдью Фарма Л.П.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45563448&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA032906(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Пэдью Фарма Л.П. filed Critical Пэдью Фарма Л.П.
Publication of EA201300747A1 publication Critical patent/EA201300747A1/ru
Publication of EA032906B1 publication Critical patent/EA032906B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретение относится к твердой лекарственной форме с контролируемым высвобождением, содержащей ядро, которое содержит первую часть опиоидного анальгетика, диспергированную в первом матричном материале, содержащем полиэтиленоксид со средней молекулярной массой от 500000 до 1000000, и оболочку, покрывающую ядро и содержащую вторую часть опиоидного анальгетика, диспергированную во втором матричном материале, содержащем полиэтиленоксид со средней молекулярной массой от 6000000 до 8000000; при этом массовое соотношение ядра к оболочке составляет от 1:1,2 до 1:1,5, и в которой соотношение опиоидного анальгетика в ядре к опиоидному анальгетику в оболочке составляет от 2:1 до 5:1, и где опиоидный анальгетик в первой и во второй частях представляет собой фармацевтически приемлемую соль гидрокодона.
EA201300747A 2010-12-22 2011-12-21 Твердая лекарственная форма с контролируемым высвобождением и способы ее получения и применения EA032906B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201061426306P 2010-12-22 2010-12-22
PCT/IB2011/003152 WO2012085656A2 (en) 2010-12-22 2011-12-21 Encased tamper resistant controlled release dosage forms

Publications (2)

Publication Number Publication Date
EA201300747A1 EA201300747A1 (ru) 2013-12-30
EA032906B1 true EA032906B1 (ru) 2019-08-30

Family

ID=45563448

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201300747A EA032906B1 (ru) 2010-12-22 2011-12-21 Твердая лекарственная форма с контролируемым высвобождением и способы ее получения и применения

Country Status (41)

Country Link
US (11) US8808740B2 (ru)
EP (4) EP2826469A1 (ru)
JP (2) JP5911509B2 (ru)
KR (2) KR101572336B1 (ru)
CN (2) CN103370058A (ru)
AP (2) AP2016009016A0 (ru)
AR (1) AR084575A1 (ru)
AU (3) AU2011346757B2 (ru)
CA (3) CA2822790C (ru)
CL (4) CL2013001781A1 (ru)
CO (1) CO6731103A2 (ru)
CR (1) CR20130544A (ru)
CY (1) CY1119312T1 (ru)
DK (1) DK2826467T3 (ru)
DO (2) DOP2013000140A (ru)
EA (1) EA032906B1 (ru)
EC (1) ECSP13012760A (ru)
ES (1) ES2643291T3 (ru)
GT (1) GT201300166A (ru)
HK (3) HK1204561A1 (ru)
HR (1) HRP20171366T1 (ru)
HU (1) HUE034955T2 (ru)
IL (1) IL226811B (ru)
LT (1) LT2826467T (ru)
ME (1) ME02874B (ru)
MX (1) MX367010B (ru)
MY (1) MY166034A (ru)
NI (1) NI201300054A (ru)
NZ (2) NZ613079A (ru)
PE (2) PE20181177A1 (ru)
PH (2) PH12015501411A1 (ru)
PL (1) PL2826467T3 (ru)
PT (1) PT2826467T (ru)
RS (1) RS56344B1 (ru)
SA (2) SA111330106B1 (ru)
SG (2) SG191288A1 (ru)
SI (1) SI2826467T1 (ru)
TN (1) TN2013000264A1 (ru)
TW (2) TW201611828A (ru)
UA (1) UA114887C2 (ru)
WO (1) WO2012085656A2 (ru)

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