MX2023008882A - N4-hidroxicitidina y derivados y usos antivirales relacionados con los mismos. - Google Patents

N4-hidroxicitidina y derivados y usos antivirales relacionados con los mismos.

Info

Publication number
MX2023008882A
MX2023008882A MX2023008882A MX2023008882A MX2023008882A MX 2023008882 A MX2023008882 A MX 2023008882A MX 2023008882 A MX2023008882 A MX 2023008882A MX 2023008882 A MX2023008882 A MX 2023008882A MX 2023008882 A MX2023008882 A MX 2023008882A
Authority
MX
Mexico
Prior art keywords
hydroxycytidine
derivatives
disclosure relates
uses related
viral uses
Prior art date
Application number
MX2023008882A
Other languages
English (en)
Inventor
George R Painter
Gregory R Bluemling
Michael G Natchus
David Guthrie
Original Assignee
Emory Univ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emory Univ filed Critical Emory Univ
Publication of MX2023008882A publication Critical patent/MX2023008882A/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Esta revelación se refiere a ciertos derivados de N4-hidroxicitidina, composiciones farmacéuticas y métodos relacionados con los mismos. En ciertas formas de realización, la revelación se relaciona con el tratamiento o la profilaxis de infecciones virales, como la Encefalitis Equina Oriental, Occidental y Venezolana (EEE, WEE y VEE, respectivamente), fiebre de Chikungunya (CHIK), Ébola, Influenza, RSV e infección por el virus del Zika con los compuestos revelados.
MX2023008882A 2017-12-07 2020-07-13 N4-hidroxicitidina y derivados y usos antivirales relacionados con los mismos. MX2023008882A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762595907P 2017-12-07 2017-12-07
US201862626998P 2018-02-06 2018-02-06
US201862760434P 2018-11-13 2018-11-13

Publications (1)

Publication Number Publication Date
MX2023008882A true MX2023008882A (es) 2023-08-09

Family

ID=66751806

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2020005392A MX2020005392A (es) 2017-12-07 2018-12-07 N4-hidroxicitidina y derivados y usos antivirales relacionados con los mismos.
MX2023008882A MX2023008882A (es) 2017-12-07 2020-07-13 N4-hidroxicitidina y derivados y usos antivirales relacionados con los mismos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2020005392A MX2020005392A (es) 2017-12-07 2018-12-07 N4-hidroxicitidina y derivados y usos antivirales relacionados con los mismos.

Country Status (16)

Country Link
US (2) US11331331B2 (es)
EP (1) EP3706762A4 (es)
JP (4) JP6804790B1 (es)
KR (3) KR102626210B1 (es)
CN (1) CN111372592A (es)
AU (2) AU2018378832B9 (es)
BR (2) BR122022008466B1 (es)
CA (1) CA3082191C (es)
GB (2) GB2590198B (es)
IL (2) IL274155B (es)
MX (2) MX2020005392A (es)
PH (1) PH12020550607A1 (es)
RU (1) RU2020116571A (es)
SG (1) SG11202004403QA (es)
WO (1) WO2019113462A1 (es)
ZA (1) ZA202002849B (es)

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