EA201800108A1 - Вакцинные композиции для профилактики абровирусных инфекций - Google Patents

Вакцинные композиции для профилактики абровирусных инфекций

Info

Publication number
EA201800108A1
EA201800108A1 EA201800108A EA201800108A EA201800108A1 EA 201800108 A1 EA201800108 A1 EA 201800108A1 EA 201800108 A EA201800108 A EA 201800108A EA 201800108 A EA201800108 A EA 201800108A EA 201800108 A1 EA201800108 A1 EA 201800108A1
Authority
EA
Eurasian Patent Office
Prior art keywords
prevention
antigens
abrovirus
infections
compositions
Prior art date
Application number
EA201800108A
Other languages
English (en)
Other versions
EA035921B1 (ru
Inventor
Кандасвами Суматхи
Кришна Муртхи Элла
Original Assignee
Бхарат Байотек Интернэшнл Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57757129&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201800108(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Бхарат Байотек Интернэшнл Лимитед filed Critical Бхарат Байотек Интернэшнл Лимитед
Publication of EA201800108A1 publication Critical patent/EA201800108A1/ru
Publication of EA035921B1 publication Critical patent/EA035921B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/5555—Muramyl dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55583—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24151—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24161—Methods of inactivation or attenuation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Mycology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Представленное раскрытие предусматривает вакцинные композиции для профилактики и лечения вирусных инфекций Зика, содержащих антигены вируса Зика в иммуногенных композициях, и в комбинации антигенов Зика с одним или несколькими антигенами арбовируса, такими как антигены вируса Чикунгунья и вируса японского энцефалита, способы получения и производства таких композиций для применения в качестве вакцины для индуцирования иммунного ответа у млекопитающих против указанных выше патогенов.
EA201800108A 2015-07-16 2016-07-15 Вакцинные композиции для профилактики арбовирусных инфекций EA035921B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN3652CH2015 2015-07-16
PCT/IN2016/050241 WO2017009873A1 (en) 2015-07-16 2016-07-15 Vaccine compositions

Publications (2)

Publication Number Publication Date
EA201800108A1 true EA201800108A1 (ru) 2018-08-31
EA035921B1 EA035921B1 (ru) 2020-08-31

Family

ID=57757129

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201800108A EA035921B1 (ru) 2015-07-16 2016-07-15 Вакцинные композиции для профилактики арбовирусных инфекций

Country Status (16)

Country Link
US (2) US10588956B2 (ru)
EP (1) EP3322441A4 (ru)
JP (2) JP6896700B2 (ru)
KR (2) KR20220144415A (ru)
CN (1) CN108601825B (ru)
AU (2) AU2016291836A1 (ru)
BR (1) BR112018000862A2 (ru)
CA (2) CA3209607A1 (ru)
CO (1) CO2018001534A2 (ru)
EA (1) EA035921B1 (ru)
MX (1) MX2018000689A (ru)
MY (1) MY187459A (ru)
PH (1) PH12018500127A1 (ru)
UA (1) UA126548C2 (ru)
WO (1) WO2017009873A1 (ru)
ZA (1) ZA201801035B (ru)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2863695C (en) 2012-02-16 2023-01-17 Vlp Therapeutics, Llc Virus like particle composition
US9637532B2 (en) 2013-07-12 2017-05-02 Vlp Therapeutics, Llc Virus like particle comprising PD-1 antigen or PD-1 ligand antigen
US10385101B2 (en) 2014-08-08 2019-08-20 Vlp Therapeutics, Llc Virus like particle comprising modified envelope protein E3
US9969986B2 (en) 2014-08-08 2018-05-15 Vlp Therapeutics, Llc Virus like particle comprising modified envelope protein E3
EP3191589A4 (en) 2014-09-11 2018-05-09 VLP Therapeutics, LLC Flavivirus virus like particle
EP3031923A1 (en) * 2014-12-11 2016-06-15 Institut Pasteur Lentiviral vector-based japanese encephalitis immunogenic composition
PL3393510T3 (pl) * 2015-12-23 2023-06-26 Valneva Austria Gmbh Szczepionka przeciwko wirusowi zika
DE112017000924T5 (de) 2016-02-22 2019-03-07 Euroimmun Medizinische Labordiagnostika Ag Ein Immuntest für die Diagnose von viralen Infektionen
MX2018010291A (es) * 2016-02-25 2019-06-06 Univ Pennsylvania Vacunas novedosas contra el virus de zika.
WO2017150683A1 (en) * 2016-03-04 2017-09-08 Vlp Therapeutics, Llc Zika virus virus like particle
US9771623B1 (en) * 2016-03-15 2017-09-26 The Board Of Regents Of The University Of Texas System Molecular typing system for flavivirus diagnostics
US20170354729A1 (en) * 2016-03-16 2017-12-14 Novavax, Inc. Vaccine compositions containing modified zika virus antigens
US11033615B2 (en) 2016-05-31 2021-06-15 The Government of the United States, As Represented by the Secretary of the Army Fort Detrick, Maryland Zika virus vaccine and methods of production
BE1024796B9 (fr) * 2016-06-02 2019-01-08 Glaxosmithkline Biologicals Sa Constructions antigeniques du virus zika
US10611801B2 (en) 2016-06-09 2020-04-07 Beth Israel Deaconess Medical Center, Inc. Compositions and methods for preventing and treating Zika virus infection
BR112018075513A2 (pt) * 2016-06-13 2019-10-01 Us Health ácidos nucleicos que codificam as partículas seme-lhantes ao vírus da zika e seu uso nas vacinas e no ensaio de diagnóstico do vírus da zika
WO2017223090A1 (en) * 2016-06-21 2017-12-28 The Trustees Of Columbia University In The City Of New York Whole-cell based vaccine against zika virus
EP3579869A4 (en) * 2017-02-14 2020-10-21 The Board of Regents of the University of Texas System LIVE ATTENUATED CIKAVIRUS WITH 3'-UTR DELETION, VACCINE WITH IT AND USE OF IT
CN110709410A (zh) * 2017-04-26 2020-01-17 豪夫迈·罗氏有限公司 可溶性和免疫反应性寨卡病毒ns1多肽
WO2018200222A1 (en) * 2017-04-26 2018-11-01 Cedars-Sinai Medical Center Methods to reduce the likelihood of maternal and fetal zika virus disease
JP2020529395A (ja) * 2017-06-12 2020-10-08 ワシントン・ユニバーシティＷａｓｈｉｎｇｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ グリオブラストーマを治療するためのジカウイルス株
WO2019042555A1 (en) 2017-08-31 2019-03-07 Humabs Biomed Sa MULTISPECIFIC ANTIBODIES SPECIFICALLY BINDING TO ZIKA VIRUS EPITOPES AND USES THEREOF
EP3703741A1 (en) * 2017-11-03 2020-09-09 Takeda Vaccines, Inc. Zika vaccines and immunogenic compositions, and methods of using the same
WO2019094801A1 (en) * 2017-11-10 2019-05-16 Research Institute At Nationwide Children's Hospital Recombinant vectors encoding zika virus protein subunits
BR112020009960A2 (pt) * 2017-11-30 2020-11-10 Takeda Vaccines, Inc. método para a inativação de vírus zika e métodos relacionados
US11491217B2 (en) 2017-12-06 2022-11-08 Emory University Chimeric viruses encoding mutant zika virus envelope glycoproteins
CN108187036A (zh) * 2017-12-08 2018-06-22 北京科兴中维生物技术有限公司 一种寨卡病毒与乙脑病毒联合灭活疫苗
AU2019244435A1 (en) * 2018-03-29 2020-10-15 Emergex Vaccines Holding Limited Vaccine compositions
CA3096036A1 (en) * 2018-04-03 2019-10-10 Vaxess Technologies, Inc. Microneedle comprising silk fibroin applied to a dissolvable base
CN112996502B (zh) * 2018-05-16 2023-10-31 普罗维克图斯药品技术公司 卤代呫吨针对难治性小儿实体瘤的体外和异种移植抗肿瘤活性
KR102253190B1 (ko) * 2018-07-18 2021-05-18 (주)진매트릭스 지카 바이러스 변이주와 이를 포함한 지카 백신 조성물
US20210308250A1 (en) * 2018-10-26 2021-10-07 New York Blood Center, Inc. Zika virus immunogenic compositions
KR101966841B1 (ko) 2018-12-12 2019-04-08 대한민국 지카바이러스 e 단백질 유래의 재조합 항원 및 이의 용도
CN109943536B (zh) * 2019-03-26 2021-09-14 昆明理工大学 一种戊型肝炎病毒的培养方法及其灭活疫苗的制备方法
AU2020269164B2 (en) * 2019-05-08 2024-04-04 Takeda Vaccines, Inc. Inactivated virus compositions and Zika vaccine formulations
KR20220045154A (ko) * 2019-08-09 2022-04-12 발네바 에스이 치쿤구니야 백신 제형
BR112022002110A2 (pt) * 2019-08-09 2022-04-19 Valneva Se Vacina do vírus da chikungunya de dose única
EP4200409A1 (en) * 2020-08-21 2023-06-28 Bharat Biotech International Limited Coronavirus vaccine and method for preparation thereof
WO2022059023A1 (en) * 2020-09-15 2022-03-24 Bharat Biotech International Limited Toll-like receptor (tlr) agonist vaccine formulation
TWI782362B (zh) * 2020-12-04 2022-11-01 臺中榮民總醫院 小黑蚊過敏無針貼片式疫苗
CN114456241B (zh) * 2021-03-01 2023-11-21 成都威斯克生物医药有限公司 抗SARS-CoV-2感染的蛋白及疫苗
WO2023017536A1 (en) * 2021-08-12 2023-02-16 Reliance Life Sciences Pvt. Ltd. Immunogenic compositions for sars- cov-2
WO2023047419A1 (en) * 2021-09-24 2023-03-30 Bharat Biotech International Limited A vaccine for coronavirus and influenza virus, and method for preparation thereof
CN114594257B (zh) * 2022-05-09 2022-08-05 北京生物制品研究所有限责任公司 含CpG ODN的吸附型疫苗的解吸附组合物及其应用
WO2024050486A2 (en) * 2022-08-31 2024-03-07 The Regents Of The University Of California Peptide-loaded antigen presenting cell-derived extracellular blebs as a molecularly targeted vaccine
CN115645523B (zh) * 2022-12-22 2023-03-21 深圳大学总医院 聚合物脂质杂化纳米粒作为免疫佐剂的应用以及一种免疫制剂

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG156666A1 (en) * 2004-10-20 2009-11-26 Acambis Inc Vaccines against japanese encephalitis virus and west nile virus
US8865184B2 (en) * 2006-09-01 2014-10-21 Bharat Biotech International Limited Vaccine for chikungunya virus infection
JP5580600B2 (ja) * 2007-12-26 2014-08-27 北里第一三共ワクチン株式会社 安定に長期間保存できる日本脳炎ワクチンの製法方法及び該ワクチンの用途
NZ603854A (en) * 2008-08-29 2015-03-27 Boehringer Ingelheim Vetmed West nile virus vaccine
EP2550292B1 (en) * 2010-03-24 2017-11-22 Research Development Foundation Flavivirus host range mutations and uses thereof
CN102512685B (zh) * 2010-12-21 2016-01-20 成都生物制品研究所有限责任公司 一种疫苗保护剂、麻疹乙型脑炎联合疫苗及其制备方法
KR101792684B1 (ko) * 2011-06-17 2017-11-02 브하라트 바이오테크 인터내셔날 리미티드 불활성화된 치쿤구니야 바이러스 균주를 포함하는 백신 조성물
CN104043117B (zh) * 2013-03-11 2018-02-13 普莱柯生物工程股份有限公司 一种疫苗组合物及其制备方法和应用
WO2016210127A1 (en) * 2015-06-25 2016-12-29 Technovax, Inc. Flavivirus and alphavirus virus-like particles (vlps)
EP3364950A4 (en) * 2015-10-22 2019-10-23 ModernaTX, Inc. VACCINES AGAINST TROPICAL DISEASES
PL3393510T3 (pl) * 2015-12-23 2023-06-26 Valneva Austria Gmbh Szczepionka przeciwko wirusowi zika
CN105749268B (zh) * 2016-04-11 2020-09-11 北京科兴中维生物技术有限公司 一种灭活的寨卡病毒疫苗

Also Published As

Publication number Publication date
EA035921B1 (ru) 2020-08-31
AU2022204267A1 (en) 2022-07-07
AU2016291836A1 (en) 2018-03-08
CA2992531A1 (en) 2017-01-19
CO2018001534A2 (es) 2018-07-10
KR20180036987A (ko) 2018-04-10
EP3322441A1 (en) 2018-05-23
US11406698B2 (en) 2022-08-09
UA126548C2 (uk) 2022-11-02
EP3322441A4 (en) 2018-12-19
JP6896700B2 (ja) 2021-06-30
PH12018500127A1 (en) 2018-07-23
KR20220144415A (ko) 2022-10-26
ZA201801035B (en) 2019-01-30
BR112018000862A2 (pt) 2018-09-11
MX2018000689A (es) 2018-09-06
CN108601825B (zh) 2023-06-20
CA2992531C (en) 2023-09-26
US20210187093A1 (en) 2021-06-24
CN108601825A (zh) 2018-09-28
WO2017009873A1 (en) 2017-01-19
MY187459A (en) 2021-09-23
JP2018527317A (ja) 2018-09-20
US10588956B2 (en) 2020-03-17
US20170014502A1 (en) 2017-01-19
CA3209607A1 (en) 2017-01-19
JP2021138745A (ja) 2021-09-16

Similar Documents

Publication Publication Date Title
EA201800108A1 (ru) Вакцинные композиции для профилактики абровирусных инфекций
MX2018007627A (es) Vacuna contra el virus del zika.
MX2018005569A (es) Vacunas contra el virus de la hepatitis b.
MX2021006931A (es) Antigenos del virus de la inmunodeficiencia humana, vectores, composiciones y metodos de uso de estos.
PH12018000197A1 (en) Hand, foot, and mouth vaccines and methods of manufacture and use thereof
MY194449A (en) Zika vaccines and immunogenic compositions, and methods of using the same
MX2015010305A (es) Vacuna de combinacion para virus sincitial respiratorio e influenza.
MX2021010060A (es) Produccion de virus en huevos aviares.
MX2020005554A (es) Vacunas y composiciones inmunogenas para zika y metodos para usarlas.
CL2018000609A1 (es) Proceso de preparación de una vacuna tetravalente atenuada contra el virus del dengue.
PH12015501716B1 (en) Anti-mycoplasma spp. subunit vaccine
WO2016011324A3 (en) 5'-triphosphate oligoribonucleotides
EA201790517A1 (ru) Способы и композиции для индуцирования защитного иммунитета против филовирусной инфекции
EA201691638A1 (ru) Новые способы индуцирования иммунного ответа
PH12016500960A1 (en) Hendra and nipah virus g glycoprotein immunogenic compositions
WO2016100615A3 (en) Methods and composition for neutralization of influenza
BR112018074910A2 (pt) composição imunológica, e, método de indução de uma resposta imunológica contra o vírus da influenza equina em um sujeito
PH12017500820A1 (en) Combination long acting compositions and methods for hepatitis c
PH12018500201A1 (en) Enhanced immune response in porcine species
PH12017500817A1 (en) Long acting pharmaceutical compositions for hepatitis c
WO2017053525A3 (en) Influenza vaccine and therapy
WO2014155297A3 (en) Systems and methods for viral inactivation of vaccine compositions by treatment with carbohydrates and radiation
AR117942A1 (es) Vacunas contra el zika, composiciones inmunogénicas y métodos que las utilizan