MD20140091A2 - Terapie combinată cuprinzând hemifumarat tenofovir alafenamidă şi cobicistat pentru utilizare în tratamentul infecţiilor virale - Google Patents

Terapie combinată cuprinzând hemifumarat tenofovir alafenamidă şi cobicistat pentru utilizare în tratamentul infecţiilor virale Download PDF

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Publication number
MD20140091A2
MD20140091A2 MDA20140091A MD20140091A MD20140091A2 MD 20140091 A2 MD20140091 A2 MD 20140091A2 MD A20140091 A MDA20140091 A MD A20140091A MD 20140091 A MD20140091 A MD 20140091A MD 20140091 A2 MD20140091 A2 MD 20140091A2
Authority
MD
Moldova
Prior art keywords
cobicistat
tenofovir alafenamide
alafenamide hemifumarate
treatment
viral infections
Prior art date
Application number
MDA20140091A
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English (en)
Moldavian (mo)
Russian (ru)
Inventor
Сринивасан Раманатан
Original Assignee
Gilead Sciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences, Inc. filed Critical Gilead Sciences, Inc.
Publication of MD20140091A2 publication Critical patent/MD20140091A2/ro

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Invenţia se referă la aplicarea formei hemifumarat de {9-[(R)-2-[[(S)-[[(S)-1-(izopropoxicarbonil)etil]amino]fenoxifosfinil]metoxi]propil]adenină} (hemifumarat tenofovir alafenamidă) în combinaţie cu cobicistat în tratamentul infecţiilor virale. Adiţional este descrisă combinaţia de hemifumarat tenofovir alafenamidă, cobicistat, emtricitabină şi elvitegravir, precum şi combinaţia de hemifumarat tenofovir alafenamidă, cobicistat, emtricitabină şi darunavir.
MDA20140091A 2012-02-03 2013-02-01 Terapie combinată cuprinzând hemifumarat tenofovir alafenamidă şi cobicistat pentru utilizare în tratamentul infecţiilor virale MD20140091A2 (ro)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201261594894P 2012-02-03 2012-02-03
US201261618411P 2012-03-30 2012-03-30
US201261624676P 2012-04-16 2012-04-16
US201261692392P 2012-08-23 2012-08-23
US201261737493P 2012-12-14 2012-12-14
PCT/US2013/024438 WO2013116720A1 (en) 2012-02-03 2013-02-01 Combination therapy comprising tenofovir alafenamide hemifumarate and cobicistat for use in the treatment of viral infections

Publications (1)

Publication Number Publication Date
MD20140091A2 true MD20140091A2 (ro) 2015-01-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20140091A MD20140091A2 (ro) 2012-02-03 2013-02-01 Terapie combinată cuprinzând hemifumarat tenofovir alafenamidă şi cobicistat pentru utilizare în tratamentul infecţiilor virale

Country Status (15)

Country Link
US (2) US20150105350A1 (ro)
EP (1) EP2809323A1 (ro)
JP (1) JP6059255B2 (ro)
KR (1) KR20140119177A (ro)
CN (1) CN104105484A (ro)
AU (3) AU2013204727A1 (ro)
BR (1) BR112014018918A8 (ro)
CA (1) CA2863662A1 (ro)
EA (1) EA026138B1 (ro)
HK (2) HK1204914A1 (ro)
IL (1) IL233874A0 (ro)
MD (1) MD20140091A2 (ro)
MX (1) MX2014009172A (ro)
NZ (1) NZ629896A (ro)
WO (2) WO2013116720A1 (ro)

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Also Published As

Publication number Publication date
JP2015505565A (ja) 2015-02-23
AU2016203666A1 (en) 2016-06-23
AU2013204727A1 (en) 2013-08-22
EP2809323A1 (en) 2014-12-10
WO2013116730A1 (en) 2013-08-08
US20170056423A1 (en) 2017-03-02
AU2013204731A1 (en) 2013-08-22
KR20140119177A (ko) 2014-10-08
MX2014009172A (es) 2014-08-27
JP6059255B2 (ja) 2017-01-11
IL233874A0 (en) 2014-09-30
EA201491287A1 (ru) 2015-04-30
EA026138B1 (ru) 2017-03-31
HK1204914A1 (en) 2015-12-11
AU2013204731C1 (en) 2017-08-31
HK1202801A1 (en) 2015-10-09
CA2863662A1 (en) 2013-08-08
BR112014018918A8 (pt) 2017-07-11
NZ629896A (en) 2016-03-31
BR112014018918A2 (ro) 2017-06-20
WO2013116720A1 (en) 2013-08-08
US20150105350A1 (en) 2015-04-16
CN104105484A (zh) 2014-10-15
AU2013204731B2 (en) 2016-03-03

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