|
US3121076A
(en)
|
|
1964-02-11 |
|
Benzodiazepinones and processes |
|
US1873732A
(en)
|
1928-12-28 |
1932-08-23 |
Abbott Lab |
Bactericide applicable to acid-fast bacteria
|
|
US3019843A
(en)
|
1956-07-27 |
1962-02-06 |
Powell Dawson |
Fire inhibitor and extinguisher
|
|
US2942572A
(en)
|
1958-06-17 |
1960-06-28 |
Pall Corp |
Magnetic pressure indicator
|
|
US3371085A
(en)
|
1959-12-10 |
1968-02-27 |
Hoffmann La Roche |
5-aryl-3h-1,4-benzodiazepin-2(1h)-ones
|
|
US3136815A
(en)
|
1959-12-10 |
1964-06-09 |
Hoffmann La Roche |
Amino substituted benzophenone oximes and derivatives thereof
|
|
US3116203A
(en)
|
1962-03-14 |
1963-12-31 |
Hoffmann La Roche |
Oleaginous systems
|
|
NL298071A
(enExample)
|
1963-06-04 |
|
|
|
|
CH449645A
(de)
|
1963-07-09 |
1968-01-15 |
Ciba Geigy |
Verfahren zur Herstellung neuer Aminosäuren
|
|
CH427803A
(de)
|
1963-12-06 |
1967-01-15 |
Geigy Ag J R |
Verfahren zur Herstellung eines neuen Isoxazolderivates
|
|
NL129434C
(enExample)
|
1966-03-12 |
|
|
|
|
US3885046A
(en)
|
1969-12-04 |
1975-05-20 |
Burroughs Wellcome Co |
Meta chloro or fluoro substituted alpha-T-butylaminopropionphenones in the treatment of depression
|
|
BE759838A
(fr)
|
1969-12-04 |
1971-06-03 |
Wellcome Found |
Cetones a activite biologique
|
|
FR2077918B1
(enExample)
|
1970-02-24 |
1973-04-06 |
Berthier Laboratoires |
|
|
US3758528A
(en)
|
1970-03-13 |
1973-09-11 |
Science Union & Cie |
Tricyclic compounds
|
|
US3821249A
(en)
|
1970-03-13 |
1974-06-28 |
En Nom Collectif Science Union |
Dibenzothiazefin derivatives
|
|
US3819631A
(en)
|
1970-12-15 |
1974-06-25 |
May & Baker Ltd |
Azapurinones
|
|
OA04285A
(fr)
|
1972-01-07 |
1979-12-31 |
Rhone Poulenc Sa |
Nouveaux dérivés de la pyrrolo (3,4-b) pyrazine et leur préparation.
|
|
USRE31617E
(en)
|
1972-02-04 |
1984-06-26 |
Bristol-Myers Company |
Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
|
|
US3932407A
(en)
|
1973-11-19 |
1976-01-13 |
Bristol-Myers Company |
Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
|
|
US4036840A
(en)
|
1972-06-07 |
1977-07-19 |
Icn Pharmaceuticals |
2-Substituted-s-triazolo[1,5a]pyrimidines
|
|
GB1457873A
(en)
|
1973-01-04 |
1976-12-08 |
Allen & Hanburys Ltd |
Imidazotriazines
|
|
GB1422263A
(en)
|
1973-01-30 |
1976-01-21 |
Ferrosan As |
4-phenyl-piperidine compounds
|
|
US4051236A
(en)
|
1973-02-15 |
1977-09-27 |
E. R. Squibb & Sons, Inc. |
Inhibition of blood platelet aggregation
|
|
US4314081A
(en)
|
1974-01-10 |
1982-02-02 |
Eli Lilly And Company |
Arloxyphenylpropylamines
|
|
US4280957A
(en)
|
1974-09-11 |
1981-07-28 |
Hoffmann-La Roche Inc. |
Imidazodiazepines and processes therefor
|
|
AR208414A1
(es)
|
1974-11-07 |
1976-12-27 |
Rhone Poulenc Ind |
Procedimiento para obtener nuevos derivados de la((acil-4piperazinil-1)carboniloxi-5 pirrolinona-2)
|
|
US4093617A
(en)
|
1974-11-12 |
1978-06-06 |
Icn Pharmaceuticals, Inc. |
3,5,7-Trisubstituted pyrazolo[1,5-a]pyrimidines
|
|
DE2460891C2
(de)
|
1974-12-21 |
1982-09-23 |
Gödecke AG, 1000 Berlin |
1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
|
|
US3960927A
(en)
|
1975-03-18 |
1976-06-01 |
Richardson-Merrell Inc. |
Olefinic derivatives of amino acids
|
|
NL7503310A
(nl)
|
1975-03-20 |
1976-09-22 |
Philips Nv |
Verbindingen met antidepressieve werking.
|
|
NL189199C
(nl)
|
1975-04-05 |
1993-02-01 |
Akzo Nv |
Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten.
|
|
FR2319338A1
(fr)
|
1975-08-01 |
1977-02-25 |
Synthelabo |
Nouveaux derives de a- phenyl benzylideniques des acides amines, leur preparation et les medicaments qui en contiennent
|
|
GB1526331A
(en)
|
1976-01-14 |
1978-09-27 |
Kefalas As |
Phthalanes
|
|
YU96177A
(en)
|
1976-04-24 |
1982-08-31 |
Wuelfing Johann A |
Process for obtaining adenine derivatives
|
|
USRE30511E
(en)
|
1977-02-03 |
1981-02-10 |
American Cyanamid Company |
Imidazo[1,5-d]-as-triazine-4(3H)-ones and thiones
|
|
US4107307A
(en)
|
1977-02-03 |
1978-08-15 |
American Cyanamid Company |
Imidazo [1,5-d]-as-triazine-4(3H)-ones and thiones
|
|
CA1095906A
(en)
|
1977-02-14 |
1981-02-17 |
Davis L. Temple, Jr. |
Heterocyclopyrimidines, compositions and therapeutic process
|
|
US4404380A
(en)
|
1977-02-14 |
1983-09-13 |
Mead Johnson & Company |
Triazolopyrimidines
|
|
US4096257A
(en)
|
1977-05-23 |
1978-06-20 |
American Cyanamid Company |
Substituted imidazo [1,2-d]-as-triazines
|
|
US4107309A
(en)
|
1977-05-23 |
1978-08-15 |
American Cyanamid Company |
Substituted imidazo[1,2-d]-as-triazines
|
|
IN148482B
(enExample)
|
1977-06-03 |
1981-03-07 |
Pfizer |
|
|
DK270278A
(da)
|
1977-06-20 |
1978-12-21 |
Krogsgaard Larsen P |
Cycliske aminosyrer
|
|
CA1086735A
(en)
|
1977-11-03 |
1980-09-30 |
John C. Danilewicz |
Piperidino-quinazolines
|
|
US4370328A
(en)
|
1977-11-03 |
1983-01-25 |
Pfizer Inc. |
Cardiac stimulant 1-(3- or 4-substituted piperidino)phthalazines
|
|
IL56369A
(en)
|
1978-01-20 |
1984-05-31 |
Erba Farmitalia |
Alpha-phenoxybenzyl propanolamine derivatives,their preparation and pharmaceutical compositions comprising them
|
|
US4146718A
(en)
|
1978-04-10 |
1979-03-27 |
Bristol-Myers Company |
Alkyl 5,6-dichloro-3,4-dihydro-2(1h)-iminoquinazoline-3-acetate hydrohalides
|
|
US4366156A
(en)
|
1979-03-05 |
1982-12-28 |
Mead Johnson & Company |
Antiallergic methods using diazaheterocyclopurines
|
|
CA1143728A
(en)
|
1979-10-04 |
1983-03-29 |
Max Gerecke |
Imidazodiazepine derivatives
|
|
US4536518A
(en)
|
1979-11-01 |
1985-08-20 |
Pfizer Inc. |
Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
|
|
JPS5668695A
(en)
|
1979-11-10 |
1981-06-09 |
Sankyo Co Ltd |
Enzyme inhibitor griseolic acid and its preparation
|
|
US4642345A
(en)
|
1980-08-14 |
1987-02-10 |
Mead Johnson & Company |
6,7-dihydro-3H-imidazo[1,2-a]-purine-9(4H)-ones
|
|
US4301176A
(en)
|
1980-08-18 |
1981-11-17 |
Warner-Lambert Company |
Method of administering calcium valproate
|
|
US4361583A
(en)
|
1980-08-19 |
1982-11-30 |
Synthelabo |
Analgesic agent
|
|
FR2492258A1
(fr)
|
1980-10-17 |
1982-04-23 |
Pharmindustrie |
Nouveau medicament a base d'amino-2 trifluoromethoxy-6 benzothiazole
|
|
FR2492382A1
(fr)
|
1980-10-22 |
1982-04-23 |
Synthelabo |
Derives d'imidazo (1,2-a) pyridine, leur preparation et leur application en therapeutique
|
|
US4489078A
(en)
|
1980-11-24 |
1984-12-18 |
Mead Johnson & Company |
Diazaheterocyclopurines used as anti-broncho spasmatics and vasodilators
|
|
US4338317A
(en)
|
1981-03-16 |
1982-07-06 |
Mead Johnson & Company |
Phenoxyethyl-1,2,4,-triazol-3-one antidepressants
|
|
US4383999A
(en)
|
1981-05-26 |
1983-05-17 |
Smithkline Beckman Corporation |
Inhibition of GABA uptake by N-substituted azaheterocyclic carboxylic acids and their esters
|
|
FR2508035A1
(fr)
|
1981-06-23 |
1982-12-24 |
Fabre Sa Pierre |
Derives d'aryl-1-aminomethyl-2 cyclopropanes carboxamides (z), leur preparation et leur application en tant que medicaments utiles dans le traitement des troubles du systeme nerveux central
|
|
LU83729A1
(fr)
|
1981-11-04 |
1983-09-01 |
Galephar |
Sels d'acide valproique,leur preparation et leur utilisation
|
|
CH655110A5
(de)
|
1982-09-03 |
1986-03-27 |
Otsuka Pharma Co Ltd |
Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten.
|
|
US4663320A
(en)
|
1983-02-16 |
1987-05-05 |
Syntex (U.S.A.) Inc. |
(2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinoazolinyl)oxyalkylamides, compositions and the use thereof
|
|
US4490371A
(en)
|
1983-02-16 |
1984-12-25 |
Syntex (U.S.A.) Inc. |
N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides
|
|
US4900836A
(en)
|
1983-06-23 |
1990-02-13 |
American Cyanamid Company |
(3-amino-1H-pyrazol-4-yl) (aryl)methanones
|
|
US4626538A
(en)
|
1983-06-23 |
1986-12-02 |
American Cyanamid Company |
[7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
|
|
US4521422A
(en)
|
1983-06-23 |
1985-06-04 |
American Cyanamid Company |
Aryl and heteroaryl[7-(aryl and heteroaryl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones
|
|
US4513006A
(en)
|
1983-09-26 |
1985-04-23 |
Mcneil Lab., Inc. |
Anticonvulsant sulfamate derivatives
|
|
US4761501A
(en)
|
1983-10-26 |
1988-08-02 |
American Home Products Corporation |
Substituted phenylacetamides
|
|
US4593029A
(en)
|
1984-02-15 |
1986-06-03 |
Syntex (U.S.A.) Inc. |
Novel ω-(N-imidazolyl)alkyl ethers of 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones
|
|
GB8425872D0
(en)
|
1984-10-12 |
1984-11-21 |
Ciba Geigy Ag |
Chemical compounds
|
|
US4855290A
(en)
|
1985-05-10 |
1989-08-08 |
State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research |
Derivatives of quinuclidine
|
|
DK288385D0
(da)
|
1985-06-26 |
1985-06-26 |
Novo Industri As |
Aminosyrederivater
|
|
ZW20586A1
(en)
|
1985-10-17 |
1988-05-25 |
Smith Kline French Lab |
Chemical compounds
|
|
US4670434A
(en)
|
1985-11-14 |
1987-06-02 |
Syntex (U.S.A.) Inc. |
(2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors
|
|
US4775674A
(en)
|
1986-05-23 |
1988-10-04 |
Bristol-Myers Company |
Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
|
|
EP0261763B1
(en)
|
1986-06-27 |
1994-02-09 |
Beecham Group Plc |
Novel bridged bicyclic N-heterocycles
|
|
GB8615785D0
(en)
|
1986-06-27 |
1986-08-06 |
Beecham Group Plc |
Compounds
|
|
FR2600650B1
(fr)
|
1986-06-27 |
1988-09-09 |
Synthelabo |
Procede de preparation d'imidazopyridines et composes intermediaires
|
|
US4701459A
(en)
|
1986-07-08 |
1987-10-20 |
Bristol-Myers Company |
7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
|
|
US4709094A
(en)
|
1986-07-10 |
1987-11-24 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon |
Sigma brain receptor ligands and their use
|
|
US5312840A
(en)
|
1986-07-10 |
1994-05-17 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education |
Substituted guanidines having high binding to the sigma receptor and the use thereof
|
|
US5385946A
(en)
|
1986-07-10 |
1995-01-31 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon |
Method for treating hypertension with disubstituted granidine compounds
|
|
US5093525A
(en)
|
1986-07-10 |
1992-03-03 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University |
N,N'-disubstituted guanidines and their use as excitatory amino acid antagonists
|
|
US4761416A
(en)
|
1986-07-25 |
1988-08-02 |
Syntex (U.S.A.) Inc. |
N-N-disubstituted-ω-[2-amino-3-(carbonylmethyl)-3, 4-dihydroquinazolinyl]oxyalkylamides and related compounds
|
|
US4739056A
(en)
|
1986-11-26 |
1988-04-19 |
Syntex (U.S.A.) Inc. |
N-N-disubstituted-omega-(2-amino-3-(carbonylmethyl)-3,4-dihydroquinazolinyl)oxy-alkylamides and related compounds
|
|
US4710508A
(en)
|
1986-12-08 |
1987-12-01 |
Warner-Lambert Company |
O-substituted tetrahydropyridine oxime cholinergic agents
|
|
US4786648A
(en)
|
1986-12-08 |
1988-11-22 |
Warner-Lambert Company |
O-substituted tetrahydropyridine oxime cholinergic agents
|
|
US4766118A
(en)
|
1986-12-22 |
1988-08-23 |
Ortho Pharmaceutical Corporation |
6-benzoxazinyl- and 6-benzothiazinyl-2,3,4,5-tetrahydropyridazin-3-ones and pharmaceutical use
|
|
US5081242A
(en)
|
1986-12-22 |
1992-01-14 |
Ortho Pharmaceutical Corporation |
6-benzoxazinyl- and 6-benzothiazinyl 2,3,4,5-tetrahydropyridazin-3-ones
|
|
US4956388A
(en)
|
1986-12-22 |
1990-09-11 |
Eli Lilly And Company |
3-aryloxy-3-substituted propanamines
|
|
US4721784A
(en)
|
1986-12-22 |
1988-01-26 |
Ortho Pharmaceutical Corporation |
6-benzoxazinyl-2,3,4,5-tetrahydropyridazin-3-ones
|
|
US4992457A
(en)
|
1987-03-18 |
1991-02-12 |
Schulman Jerome M |
Pharmacologically active cholinergic compositions, and methods for making same and use thereof in treating disease
|
|
US4929734A
(en)
|
1987-03-31 |
1990-05-29 |
Warner-Lambert Company |
Tetrahydropyridine oxime compounds
|
|
EP0287356B1
(en)
|
1987-04-15 |
1996-01-24 |
Beecham Group Plc |
Bridgehead substituted azabicyclic derivatives
|
|
GB8714789D0
(en)
|
1987-06-24 |
1987-07-29 |
Lundbeck & Co As H |
Heterocyclic compounds
|
|
US4981858A
(en)
|
1987-08-13 |
1991-01-01 |
State Of Israel, Represented By The Prime Minister's Office, Israel Institute For Biological Research |
Optical isomers
|
|
US5232917A
(en)
|
1987-08-25 |
1993-08-03 |
University Of Southern California |
Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series
|
|
USRE35517E
(en)
|
1987-08-25 |
1997-05-20 |
University Of Southern California |
Method, compositions, and compounds for modulating brain excitability
|
|
ATE122353T1
(de)
|
1987-10-05 |
1995-05-15 |
Yamanouchi Pharma Co Ltd |
Heterozyklische spiroverbindungen und ihre herstellung.
|
|
US5412096A
(en)
|
1987-10-05 |
1995-05-02 |
Yamanouchi Pharmaceutical Co., Ltd. |
Hydrochloride salts of heterocyclic spiro compounds
|
|
IE63906B1
(en)
|
1987-11-13 |
1995-06-14 |
Novo Nordisk As |
Azabicyclic compounds and their preparation and use
|
|
EP0322182A3
(en)
|
1987-12-22 |
1992-01-02 |
Beecham Group Plc |
Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them
|
|
US4831031A
(en)
|
1988-01-22 |
1989-05-16 |
Pfizer Inc. |
Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
|
|
US5091431A
(en)
|
1988-02-08 |
1992-02-25 |
Schering Corporation |
Phosphodiesterase inhibitors
|
|
PT90266B
(pt)
|
1988-04-15 |
1994-07-29 |
Beecham Group Plc |
Processo para a preparacao de compostos azabiciclicos
|
|
US4957916A
(en)
|
1988-08-05 |
1990-09-18 |
Janssen Pharmaceutica N.V. |
Antipsychotic 3-piperazinylbenzazole derivatives
|
|
US4861891A
(en)
|
1988-08-31 |
1989-08-29 |
Pfizer Inc. |
Antidepressant N-substituted nicotinamide compounds
|
|
CA2000041A1
(en)
|
1988-10-13 |
1990-04-13 |
Barry S. Orlek |
Compounds
|
|
DE8817121U1
(de)
|
1988-11-22 |
1993-02-04 |
Boehringer Ingelheim Kg, 55218 Ingelheim |
Neue Quinuclidine
|
|
US5286864A
(en)
|
1988-11-22 |
1994-02-15 |
Boehringer Ingelheim Kg |
Quinuclidines, their use as medicaments and processes for their preparation
|
|
US5043345A
(en)
|
1989-02-22 |
1991-08-27 |
Novo Nordisk A/S |
Piperidine compounds and their preparation and use
|
|
US4981870A
(en)
|
1989-03-07 |
1991-01-01 |
Pfizer Inc. |
Use of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine derivatives in the treatment of psychosis, inflammation and as immunosuppressants
|
|
US4971972A
(en)
|
1989-03-23 |
1990-11-20 |
Schering Corporation |
Phosphodiesterase inhibitors having an optionally substituted purine derivative portion and a benzo- or cyclopenta-furan portion
|
|
SG48315A1
(en)
|
1989-04-13 |
1998-04-17 |
Beecham Group Plc |
Novel compounds
|
|
US5278170A
(en)
|
1989-04-13 |
1994-01-11 |
Beecham Group P.L.C. |
Azabicylo oxime compounds
|
|
US4956368A
(en)
|
1989-07-24 |
1990-09-11 |
Bristol-Myers Company |
Metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione
|
|
US5109002A
(en)
|
1989-09-08 |
1992-04-28 |
Du Pont Merck Pharmaceutical Company |
Antipsychotic 1-cycloalkylpiperidines
|
|
EP0427390B1
(en)
|
1989-10-07 |
1996-03-27 |
Beecham Group Plc |
Azabicyclic compounds, process and intermediates for their preparation and pharmaceutical compositions containing them
|
|
US4943573A
(en)
|
1989-11-01 |
1990-07-24 |
Bristol-Myers Squibb Company |
Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
|
|
CA2029497C
(en)
|
1989-11-08 |
2002-06-04 |
Kunihiro Ninomiya (Deceased) |
4-acylaminopyridine derivative
|
|
US5010086A
(en)
|
1990-02-28 |
1991-04-23 |
Sterling Drug Inc. |
Imidazopyridines, compositions and use
|
|
US4963561A
(en)
|
1990-02-28 |
1990-10-16 |
Sterling Drug Inc. |
Imidazopyridines, their preparation and use
|
|
US5149817A
(en)
|
1990-03-05 |
1992-09-22 |
Shionogi & Co., Ltd. |
Teirahydropyridine derivatives
|
|
GB9005737D0
(en)
|
1990-03-14 |
1990-05-09 |
Beecham Group Plc |
Novel compounds
|
|
US5169855A
(en)
|
1990-03-28 |
1992-12-08 |
Du Pont Merck Pharmaceutical Company |
Piperidine ether derivatives as psychotropic drugs or plant fungicides
|
|
US5534520A
(en)
|
1990-04-10 |
1996-07-09 |
Fisher; Abraham |
Spiro compounds containing five-membered rings
|
|
US5852029A
(en)
|
1990-04-10 |
1998-12-22 |
Israel Institute For Biological Research |
Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
|
|
US5407938A
(en)
|
1990-04-10 |
1995-04-18 |
Israel Institute For Biological Research |
Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines)
|
|
US5116995A
(en)
|
1990-05-25 |
1992-05-26 |
Taisho Pharmaceutical Co., Ltd. |
Carbazole compounds
|
|
WO1991018868A1
(en)
|
1990-05-25 |
1991-12-12 |
STATE OF OREGON, acting by and through the OREGON STATE BOARD OF HIGHER EDUCATION, acting for and onbehalf of the OREGON HEALTH SCIENCES UNIVERSITY |
Substituted guanidines having high binding to the sigma receptor and the use thereof
|
|
US5612211A
(en)
|
1990-06-08 |
1997-03-18 |
New York University |
Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors
|
|
US5250534A
(en)
|
1990-06-20 |
1993-10-05 |
Pfizer Inc. |
Pyrazolopyrimidinone antianginal agents
|
|
US5095015A
(en)
|
1990-07-24 |
1992-03-10 |
Neurogen Corporation |
Certain azacycloalkyl imidazopyrimidines; a new class of gaba brain receptor ligands
|
|
JP2935541B2
(ja)
|
1990-06-28 |
1999-08-16 |
サントリー株式会社 |
縮合複素環化合物
|
|
US5086054A
(en)
|
1990-07-31 |
1992-02-04 |
Sri International |
Novel arylcycloalkanepolyalkylamines
|
|
US5376668A
(en)
|
1990-08-21 |
1994-12-27 |
Novo Nordisk A/S |
Heterocyclic compounds
|
|
DK198590D0
(da)
|
1990-08-21 |
1990-08-21 |
Novo Nordisk As |
Heterocykliske forbindelser, deres fremstilling og anvendelse
|
|
US5527813A
(en)
|
1990-08-21 |
1996-06-18 |
Novo Nordisk A/S |
Heterocyclic compounds and their preparation and use
|
|
WO1992003435A1
(en)
|
1990-08-24 |
1992-03-05 |
Beecham Group Plc |
Azabicyclic compounds, process and intermediates for their preparation and pharmaceutical compositions containing them
|
|
CA2050264A1
(en)
|
1990-08-30 |
1992-03-01 |
Raymond Baker |
Substituted pyrazine and its salts, compositions containing them and their use in medicine
|
|
GB9019095D0
(en)
|
1990-09-01 |
1990-10-17 |
Beecham Group Plc |
Novel compounds
|
|
US5185446A
(en)
|
1990-09-04 |
1993-02-09 |
Neurogen Corporation |
Certain cycloalkyl imidazopyrimidines; a new class of gaba brainreceptor ligands
|
|
JPH06502147A
(ja)
|
1990-10-09 |
1994-03-10 |
ニューロゲン コーポレイション |
或る種のシクロアルキルおよびアザシクロアルキルピロロピリミジン；新規な種類のｇａｂａ脳リセプタリガンド
|
|
CA2093823A1
(en)
|
1990-10-12 |
1992-04-13 |
Steven M. Bromidge |
1,2,5,6-tetrahydropyridine oxime derivatives
|
|
US5139802A
(en)
|
1990-10-15 |
1992-08-18 |
Nestec S.A. |
Oxidation of tea
|
|
ATE118306T1
(de)
|
1990-10-15 |
1995-03-15 |
Nestle Sa |
Behandlung von schwarzem tee.
|
|
US5091242A
(en)
|
1990-10-30 |
1992-02-25 |
The Research Foundation Of State Univ. Of N.Y. |
Carbon fiber composites having improved fatigue resistance
|
|
US6268496B1
(en)
|
1990-10-31 |
2001-07-31 |
Neurogen Corporation |
Certain imidazoquinoxalines: a new class of GABA brain receptor ligands
|
|
US5130430A
(en)
|
1990-10-31 |
1992-07-14 |
Neurogen Corporation |
2-substituted imidazoquinoxaline diones, a new class of gaba brain receptor ligands
|
|
US5744602A
(en)
|
1990-10-31 |
1998-04-28 |
Neurogen Corporation |
Certain imidazoquinoxalines; a new class of GABA brain receptor ligands
|
|
US5116837A
(en)
|
1990-12-21 |
1992-05-26 |
Ortho Pharmaceutical Corporation |
2,9-dihydro-(6 or 7)-(3-oxo-2,3,4,5-tetrahydropyridazinyl)-pyrazolo [4,3-B]-1,4-benzoxazines
|
|
US5162341A
(en)
|
1991-02-22 |
1992-11-10 |
Du Pont Merck Pharmaceutical Company |
Use of sigma receptor antagonists for treatment of amphetamine abuse
|
|
US5137895A
(en)
|
1991-04-29 |
1992-08-11 |
A. H. Robins Company, Incorporated |
3-[N-aroyl(or thioaroyl)aminomethyl]-3-quinuclidinols
|
|
US5093333A
(en)
|
1991-04-29 |
1992-03-03 |
American Home Products Corporation |
N-substituted-2-aminoquinolines useful for treating hypofunction of the cholinergic system
|
|
US5124460A
(en)
|
1991-05-06 |
1992-06-23 |
Merck Sharp & Dohme Ltd. |
Enantioselective synthesis of 3-substituted 1-azabicyclo (2.2.1)heptanes
|
|
DE69226187T2
(de)
|
1991-05-15 |
1998-10-22 |
Yamanouchi Pharma Co Ltd |
(-)-(s)-2,8-dimethyl-3-methylen-1-oxa-8-azaspiro(4,5)decan l-tartrat
|
|
NZ243065A
(en)
|
1991-06-13 |
1995-07-26 |
Lundbeck & Co As H |
Piperidine derivatives and pharmaceutical compositions
|
|
US5641791A
(en)
|
1991-08-13 |
1997-06-24 |
Novo Nordisk A.S |
Heterocyclic compounds and their preparation and use
|
|
US5182386A
(en)
|
1991-08-27 |
1993-01-26 |
Neurogen Corporation |
Certain imidazoquinoxalinones; a new class of gaba brain receptor ligands
|
|
US5182290A
(en)
|
1991-08-27 |
1993-01-26 |
Neurogen Corporation |
Certain oxazoloquinolinones; a new class of GABA brain receptor ligands
|
|
US5369108A
(en)
|
1991-10-04 |
1994-11-29 |
Sloan-Kettering Institute For Cancer Research |
Potent inducers of terminal differentiation and methods of use thereof
|
|
US5585490A
(en)
|
1991-10-08 |
1996-12-17 |
Neurogen Corporation |
Certain cycloalkyl and azacycloalkyl pyrrolopyrimidines; a new class of GABA brain receptor ligands
|
|
US5212310A
(en)
|
1991-12-19 |
1993-05-18 |
Neurogen Corporation |
Certain aryl fused imidazopyrimidines; a new class of GABA brain receptor ligands
|
|
US5243049A
(en)
|
1992-01-22 |
1993-09-07 |
Neurogen Corporation |
Certain pyrroloquinolinones: a new class of GABA brain receptor ligands
|
|
MX9300875A
(es)
|
1992-02-20 |
1993-08-31 |
Smithkline Beecham Plc |
Procedimiento para la preparacion de compuestos azabiciclicos.
|
|
US6225115B1
(en)
|
1992-03-04 |
2001-05-01 |
Synaptic Pharmaceutical Corporation |
DNA encoding taurine and GABA transporters and uses thereof
|
|
US5298657A
(en)
|
1992-03-20 |
1994-03-29 |
Cambridge Neuroscience Inc. |
Preparation of substituted guanidines
|
|
US5294612A
(en)
|
1992-03-30 |
1994-03-15 |
Sterling Winthrop Inc. |
6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof
|
|
US5367077A
(en)
|
1992-04-08 |
1994-11-22 |
Neurogen Corporation |
Certain cycloalkyl and azacycloalkyl pyrrolopyridines; a new class of gaba rain receptor ligands
|
|
WO1994025463A1
(en)
|
1992-04-08 |
1994-11-10 |
Neurogen Corporation |
Certain aryl fused pyrrolopyrimidines; a new class of gaba brain receptor ligands
|
|
US5266698A
(en)
|
1992-04-30 |
1993-11-30 |
Neurogen Corporation |
Certain aryl and cycloalkyl fused imidazopyrazinediones; a new class of GABA brain receptor ligands
|
|
SE9201478D0
(sv)
|
1992-05-11 |
1992-05-11 |
Kabi Pharmacia Ab |
Heteroaromatic quinuclidinenes, their use and preparation
|
|
ES2060547B1
(es)
|
1992-06-04 |
1995-06-16 |
Ferrer Int |
Mejoras en el objeto de la patente de invencion n/ 9201158 que se refiere a "procedimiento de obtencion de nuevos derivados de la 4-bencilpiperidina".
|
|
GB9212673D0
(en)
|
1992-06-15 |
1992-07-29 |
Celltech Ltd |
Chemical compounds
|
|
GB9212693D0
(en)
|
1992-06-15 |
1992-07-29 |
Celltech Ltd |
Chemical compounds
|
|
JP2683783B2
(ja)
|
1992-07-10 |
1997-12-03 |
雪印乳業株式会社 |
シェーグレン症候群治療剤
|
|
US5672499A
(en)
|
1992-07-27 |
1997-09-30 |
California Institute Of Technology |
Immoralized neural crest stem cells and methods of making
|
|
US5306819A
(en)
|
1992-08-27 |
1994-04-26 |
Neurogen Corporation |
Certain aryl a cycloalkyl fused imidazopyrazinols; and new class of GABA brain receptor ligands
|
|
ZA937382B
(en)
|
1992-10-06 |
1994-04-29 |
Warner Lambert Co |
Novel composition for peroral therapy of cognitionimpairment and a process therefor
|
|
GB9222253D0
(en)
|
1992-10-23 |
1992-12-09 |
Celltech Ltd |
Chemical compounds
|
|
US5668283A
(en)
|
1992-11-12 |
1997-09-16 |
Neurogen Corporation |
Certain aryl substituted pyrrolopyrazines; a new class of GABA brain receptor ligands
|
|
US5286860A
(en)
|
1992-11-12 |
1994-02-15 |
Neurogen Corporation |
Certain aryl substituted pyrrolopyrazines; a new class of GABA brain receptor ligands
|
|
US5814651A
(en)
|
1992-12-02 |
1998-09-29 |
Pfizer Inc. |
Catechol diethers as selective PDEIV inhibitors
|
|
US5622977A
(en)
|
1992-12-23 |
1997-04-22 |
Celltech Therapeutics Limited |
Tri-substituted (aryl or heteroaryl) derivatives and pharmaceutical compositions containing the same
|
|
AU5991294A
(en)
|
1993-01-06 |
1994-08-15 |
Neurogen Corporation |
Certain aryl substituted imidazopyrazinones a new class of gaba brain receptor ligands
|
|
ES2098799T3
(es)
|
1993-01-23 |
1997-05-01 |
Hoechst Ag |
2,3-difluoro-6-nitro-benzonitrilo y 2-cloro-5,6-difluoro-benzonitrilo, procedimiento para su preparacion y su utilizacion para la preparacion de acido 2,3,6-trifluoro-benzoico.
|
|
US5424301A
(en)
|
1993-02-01 |
1995-06-13 |
Warner-Lambert Company |
Starch stabilized o-substituted tetrahydropyridine oxime cholinergic agents
|
|
US5362860A
(en)
|
1993-02-01 |
1994-11-08 |
Warner-Lambert Company |
Neutral stabilization complex for CI-979 HCl, a cognition activator
|
|
US6013799A
(en)
|
1993-03-03 |
2000-01-11 |
Neurogen Corporation |
Certain cycloalkyl imidazopyrimides, a new class of gaba brain receptor ligands
|
|
GB9304920D0
(en)
|
1993-03-10 |
1993-04-28 |
Celltech Ltd |
Chemical compounds
|
|
GB9304919D0
(en)
|
1993-03-10 |
1993-04-28 |
Celltech Ltd |
Chemical compounds
|
|
WO1994022843A1
(en)
|
1993-03-26 |
1994-10-13 |
Schering Corporation |
2-substituted morpholine and thiomorpholine derivatives as gaba-b antagonists
|
|
US5750702A
(en)
|
1993-10-27 |
1998-05-12 |
Neurogen Corporation |
Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands
|
|
ES2204920T3
(es)
|
1993-05-27 |
2004-05-01 |
Cenes Limited |
Guanidinas substituidas terapeuticas.
|
|
GB9301192D0
(en)
|
1993-06-09 |
1993-06-09 |
Trott Francis W |
Flower shaped mechanised table
|
|
US6087346A
(en)
|
1993-06-23 |
2000-07-11 |
Cambridge Neuroscience, Inc. |
Sigma receptor ligands and the use thereof
|
|
DE59410119D1
(de)
|
1993-07-02 |
2002-06-20 |
Byk Gulden Lomberg Chem Fab |
Fluoralkoxy substituierte benzamide und ihre verwendung als zyklisch-nukleotid phosphodiesterase-inhibitoren
|
|
ES2074946B1
(es)
|
1993-07-19 |
1996-06-16 |
Ferrer Int |
Nuevos compuestos derivados de la 1,2-etanodiamina-n,n,n',n'-tetrasustituida.
|
|
US5665754A
(en)
|
1993-09-20 |
1997-09-09 |
Glaxo Wellcome Inc. |
Substituted pyrrolidines
|
|
US5484944A
(en)
|
1993-10-27 |
1996-01-16 |
Neurogen Corporation |
Certain fused pyrrolecarboxanilides and their use as GABA brain receptor ligands
|
|
EP0730587B1
(en)
|
1993-11-26 |
1999-12-08 |
Pfizer Inc. |
3-phenyl-2-isoxazolines as antiinflammatory agents
|
|
ATE154932T1
(de)
|
1993-11-26 |
1997-07-15 |
Pfizer |
Isoxazolinverbindungen als entzündungshemmende mittel
|
|
US5502072A
(en)
|
1993-11-26 |
1996-03-26 |
Pfizer Inc. |
Substituted oxindoles
|
|
US5500420A
(en)
|
1993-12-20 |
1996-03-19 |
Cornell Research Foundation, Inc. |
Metabotropic glutamate receptor agonists in the treatment of cerebral ischemia
|
|
GB9326173D0
(en)
|
1993-12-22 |
1994-02-23 |
Celltech Ltd |
Chemical compounds and process
|
|
ATE260911T1
(de)
|
1993-12-22 |
2004-03-15 |
Celltech R&D Ltd |
Trisubstituierte phenyl-derivate, verfahren zu deren herstellung und deren verwendung als phosphodiesterase (typ iv) hemmstoffe
|
|
GB9326699D0
(en)
|
1993-12-22 |
1994-03-02 |
Celltech Ltd |
Chemical compounds
|
|
EP0734723A4
(en)
|
1993-12-29 |
2001-04-11 |
Kowa Tekuno Sachi Co Ltd |
THERAPEUTIC COMPOSITION USEFUL FOR TREATING HYPERPARATHYROIDIA OF A PATIENT ON ARTIFICIAL DIALYSIS
|
|
US7060450B1
(en)
|
1993-12-30 |
2006-06-13 |
President And Fellows Of Harvard College |
Screening assays for agonists and antagonists of the hedgehog signaling pathway
|
|
GB9401090D0
(en)
|
1994-01-21 |
1994-03-16 |
Glaxo Lab Sa |
Chemical compounds
|
|
GB9514465D0
(en)
|
1995-07-14 |
1995-09-13 |
Glaxo Lab Sa |
Chemical compounds
|
|
US5939545A
(en)
|
1994-02-14 |
1999-08-17 |
Cocensys, Inc. |
Method, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series
|
|
DK0752860T3
(da)
|
1994-02-14 |
2000-11-13 |
Euro Celtique Sa |
Androstaner og pregnaner til allosterisk modulering af GABA-receptor
|
|
US5783575A
(en)
|
1994-03-14 |
1998-07-21 |
Novo Nordisk A/S |
Antagonists, their preparation and use
|
|
US5696148A
(en)
|
1994-03-14 |
1997-12-09 |
Novo Nordisk A/S |
Indole compounds and their use in treating diseases of the central nervous system
|
|
AU697183B2
(en)
|
1994-03-14 |
1998-10-01 |
Novo Nordisk A/S |
Thieno{ 2,3-b}indoles, their preparation and use
|
|
US5637617A
(en)
|
1994-04-01 |
1997-06-10 |
The Regents Of The University Of California |
Methods for use of GABAa receptor GABAergic compounds
|
|
GB9409718D0
(en)
|
1994-05-14 |
1994-07-06 |
Smithkline Beecham Plc |
Novel compounds
|
|
GB9409705D0
(en)
|
1994-05-14 |
1994-07-06 |
Smithkline Beecham Plc |
Novel compounds
|
|
US6245774B1
(en)
|
1994-06-21 |
2001-06-12 |
Celltech Therapeutics Limited |
Tri-substituted phenyl or pyridine derivatives
|
|
US5786354A
(en)
|
1994-06-21 |
1998-07-28 |
Celltech Therapeutics, Limited |
Tri-substituted phenyl derivatives and processes for their preparation
|
|
GB9412571D0
(en)
|
1994-06-22 |
1994-08-10 |
Celltech Ltd |
Chemical compounds
|
|
GB9412573D0
(en)
|
1994-06-22 |
1994-08-10 |
Celltech Ltd |
Chemical compounds
|
|
GB9412672D0
(en)
|
1994-06-23 |
1994-08-10 |
Celltech Ltd |
Chemical compounds
|
|
JP2852608B2
(ja)
|
1994-06-27 |
1999-02-03 |
雪印乳業株式会社 |
口腔乾燥症治療剤
|
|
US5661184A
(en)
|
1994-08-12 |
1997-08-26 |
Eli Lilly And Company |
Psychiatric agents
|
|
PT777671E
(pt)
|
1994-08-24 |
2000-08-31 |
Astrazeneca Ab |
Compostos espiro-azabiciclicos uteis em terapia
|
|
US5817670A
(en)
|
1994-08-29 |
1998-10-06 |
Yamanouchi Pharmaceutical Co., Ltd. |
Naphthyridine derivatives and pharmaceutical compositions thereof
|
|
US5731307A
(en)
|
1994-09-30 |
1998-03-24 |
Pfizer, Inc. |
Neuroleptic 2,7-disubtituted perhydro-1h-pyrido 1, 2-A!pyrazines
|
|
US5554645A
(en)
|
1994-10-03 |
1996-09-10 |
Mars, Incorporated |
Antineoplastic cocoa extracts and methods for making and using the same
|
|
DE4436509A1
(de)
|
1994-10-13 |
1996-04-18 |
Hoechst Schering Agrevo Gmbh |
Substituierte Spiroalkylamino- und alkoxy-Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel und Fungizide
|
|
JP3993651B2
(ja)
|
1994-10-21 |
2007-10-17 |
アスビオファーマ株式会社 |
シクロプロパクロメンカルボン酸誘導体
|
|
US5821370A
(en)
|
1994-10-24 |
1998-10-13 |
Eli Lilly And Company |
Heterocyclic compounds and their preparation and use
|
|
US5605908A
(en)
|
1994-10-24 |
1997-02-25 |
Eli Lilly And Company |
Heterocyclic compounds and their use
|
|
US5473077A
(en)
|
1994-11-14 |
1995-12-05 |
Eli Lilly And Company |
Pyrrolidinyl di-carboxylic acid derivatives as metabotropic glutamate receptor agonists
|
|
US5571819A
(en)
|
1994-11-22 |
1996-11-05 |
Sabb; Annmarie L. |
Imidazopyridines as muscarinic agents
|
|
US5510478A
(en)
|
1994-11-30 |
1996-04-23 |
American Home Products Corporation |
2-arylamidothiazole derivatives with CNS activity
|
|
US5512574A
(en)
|
1994-12-21 |
1996-04-30 |
American Home Products Corporation |
Quinuclidine and azabicyclo 2.2.1! heptane pyrazinyl ethers as muscarinic agonists
|
|
US5468875A
(en)
|
1994-12-22 |
1995-11-21 |
American Home Products Corporation |
1-azabicycloheptane derivatives
|
|
GB9503601D0
(en)
|
1995-02-23 |
1995-04-12 |
Merck Sharp & Dohme |
Method of treatment and method of manufacture of medicament
|
|
US5488055A
(en)
|
1995-03-10 |
1996-01-30 |
Sanofi Winthrop Inc. |
Substituted N-cycloalkylmethyl-1H-pyrazolo(3,4-b)quinolin-4 amines and compositions and methods of use thereof
|
|
RU2135493C1
(ru)
|
1995-04-21 |
1999-08-27 |
Нюросерч А/С |
Производное бензимидазола, фармацевтический состав и способ модуляции гамка-рецепторного комплекса
|
|
AU5644396A
(en)
|
1995-05-05 |
1996-11-21 |
Novo Nordisk A/S |
Novel heterocyclic chemistry
|
|
DE19518082A1
(de)
|
1995-05-17 |
1996-11-21 |
Merck Patent Gmbh |
4(-Arylaminomethylen)-2,4-dihydropyrazol-3-one
|
|
DE59610031D1
(de)
|
1995-05-18 |
2003-02-06 |
Altana Pharma Ag |
Cyclohexyldihydrobenzofurane
|
|
AU698028B2
(en)
|
1995-05-18 |
1998-10-22 |
Altana Pharma Ag |
Phenyldihydrobenzofurans
|
|
US6514996B2
(en)
|
1995-05-19 |
2003-02-04 |
Kyowa Hakko Kogyo Co., Ltd. |
Derivatives of benzofuran or benzodioxole
|
|
US5637725A
(en)
|
1995-06-05 |
1997-06-10 |
Neurogen Corporation |
Substituted aryl and cycloalkyl imidazolones; a new class of GABA brain receptor ligands
|
|
US5637724A
(en)
|
1995-06-05 |
1997-06-10 |
Neurogen Corporation |
Substituted aryl and cycloalkyl imidazolones; a new class of GABA brain receptor ligands
|
|
EP1288220A3
(en)
|
1995-06-06 |
2004-07-21 |
Euro-Celtique |
Neuroactive 3.alpha.-hydroxy-steroids of the androstane and pregnane series
|
|
US5910590A
(en)
|
1995-06-07 |
1999-06-08 |
Neurogen Corporation |
Certain aryl substituted pyrrolopyrazines; a new class of GABA brain receptor ligands
|
|
US5534522A
(en)
|
1995-06-07 |
1996-07-09 |
Warner-Lambert Company |
(R)-(Z)-1-azabicyclo [2.2.1] heptan-3-one,O-[3-(3-methoxyphenyl)-2-propynyl] oxime maleate as a pharmaceutical agent
|
|
GB9514464D0
(en)
|
1995-07-14 |
1995-09-13 |
Glaxo Lab Sa |
Medicaments
|
|
WO1997005105A1
(en)
|
1995-07-26 |
1997-02-13 |
Pfizer Inc. |
N-(aroyl)glycine hydroxamic acid derivatives and related compounds
|
|
US20010018074A1
(en)
|
1995-07-29 |
2001-08-30 |
Smithkline Beecham P.L.C. |
Process for preparing solid dosage forms of very low-dose drugs
|
|
US5945417A
(en)
|
1995-07-31 |
1999-08-31 |
Novo Nordisk |
Heterocyclic compounds, their preparation and use
|
|
DE19533975A1
(de)
|
1995-09-14 |
1997-03-20 |
Merck Patent Gmbh |
Arylalkyl-diazinone
|
|
US6166041A
(en)
|
1995-10-11 |
2000-12-26 |
Euro-Celtique, S.A. |
2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
|
|
US5800539A
(en)
|
1995-11-08 |
1998-09-01 |
Emory University |
Method of allogeneic hematopoietic stem cell transplantation without graft failure or graft vs. host disease
|
|
US5912248A
(en)
|
1995-11-16 |
1999-06-15 |
Eli Lilly And Company |
Excitatory amino acid receptor antagonists
|
|
ZA969485B
(en)
|
1995-11-16 |
1998-05-12 |
Lilly Co Eli |
Excitatory amino acid receptor antagonists.
|
|
US5688826A
(en)
|
1995-11-16 |
1997-11-18 |
Eli Lilly And Company |
Excitatory amino acid derivatives
|
|
US5756501A
(en)
|
1995-12-13 |
1998-05-26 |
American Home Products Corporation |
Saturated and unsaturated pyridazino 4,5-B! indolizines useful as antidementia agents
|
|
GB9603723D0
(en)
|
1996-02-22 |
1996-04-24 |
Merck & Co Inc |
Diphenyl pyridyl derivatives as pde iv inhibitors
|
|
US5710170A
(en)
|
1995-12-15 |
1998-01-20 |
Merck Frosst Canada, Inc. |
Tri-aryl ethane derivatives as PDE IV inhibitors
|
|
GB9526246D0
(en)
|
1995-12-21 |
1996-02-21 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9526245D0
(en)
|
1995-12-21 |
1996-02-21 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
GB9526243D0
(en)
|
1995-12-21 |
1996-02-21 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
US5804686A
(en)
|
1996-01-19 |
1998-09-08 |
Neurogen Corporation |
fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
|
|
US6211365B1
(en)
|
1996-01-19 |
2001-04-03 |
Neurogen Corporation |
Fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
|
|
BR9707233A
(pt)
|
1996-01-31 |
1999-07-20 |
Byk Gulden Lomberg Chem Fab |
Fenantridinas
|
|
GB9604926D0
(en)
|
1996-03-08 |
1996-05-08 |
Sandoz Ltd |
Organic compounds
|
|
US5792766A
(en)
|
1996-03-13 |
1998-08-11 |
Neurogen Corporation |
Imidazo 1,5-c! quinazolines; a new class of GABA brain receptor ligands
|
|
US5677309A
(en)
|
1996-03-22 |
1997-10-14 |
Neurogen Corporation |
1,2,4-triazolo 4,3-c! quinazolin-3-ones and 1,2,4-triazolo 4,3-c!quinazolin-3-thiones; a new class of GABA brain receptor ligands
|
|
AU2218997A
(en)
|
1996-03-22 |
1997-10-10 |
Neurogen Corporation |
Certain fused pyrrolecarboxamides as gaba brain receptor ligands
|
|
US6127378A
(en)
|
1996-03-26 |
2000-10-03 |
Byk Gulden Lomberg Chemische Fabrik Gmbh |
Phenanthridines substituted in the 6 position
|
|
US6777217B1
(en)
|
1996-03-26 |
2004-08-17 |
President And Fellows Of Harvard College |
Histone deacetylases, and uses related thereto
|
|
FR2746800B1
(fr)
|
1996-03-29 |
1998-06-05 |
Jouveinal Inst Rech |
Diazepino-indoles inhibiteurs de phosphodiesterases 4
|
|
US6297273B1
(en)
|
1996-04-02 |
2001-10-02 |
Mars, Inc. |
Use of cocoa solids having high cocoa polyphenol content in tabletting compositions and capsule filling compositions
|
|
FR2754260B1
(fr)
|
1996-10-04 |
1998-10-30 |
Adir |
Nouveaux derives substitues de biphenyle ou de phenylpyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
US5723462A
(en)
|
1996-04-26 |
1998-03-03 |
Neurogen Corporation |
Certain fused pyrrolecarboxamides a new class of GABA brain receptor ligands
|
|
US20020103194A1
(en)
|
1997-04-30 |
2002-08-01 |
Anabella Villalobos |
Novel muscarinic receptor agonists
|
|
PL329875A1
(en)
|
1996-05-10 |
1999-04-12 |
Icos Corp |
Derivatives of carbolin
|
|
US6017924A
(en)
|
1996-06-27 |
2000-01-25 |
Ligand Pharmaceuticals Incorporated |
Androgen receptor modulator compounds and methods
|
|
US20020127271A1
(en)
|
1996-07-25 |
2002-09-12 |
Smithkline Beecham P.L.C. |
Formulation for the treatment and/or prophylaxis of dementia
|
|
AU723098B2
(en)
|
1996-07-25 |
2000-08-17 |
Merck Sharp & Dohme Limited |
Substituted triazolo-pyridazine derivatives as ligands for GABA receptors
|
|
NZ334613A
(en)
|
1996-08-12 |
2002-02-01 |
Welfide Corp |
Pharmaceutical agents comprising Rho kinase inhibitor
|
|
DE19632549A1
(de)
|
1996-08-13 |
1998-02-19 |
Merck Patent Gmbh |
Arylalkanoylpyridazine
|
|
ATE229516T1
(de)
|
1996-08-19 |
2002-12-15 |
Altana Pharma Ag |
Benzofuran-4-carboxamide
|
|
SI0920426T1
(en)
|
1996-08-26 |
2004-04-30 |
Altana Pharma Ag |
New thiazole derivatives with phosphodiesterase-inhibiting effect
|
|
US20010003588A1
(en)
|
1996-09-12 |
2001-06-14 |
Smithkline Beecham Corporation |
Controlled release dosage form of [R-(Z)]-alpha-(methoxyimino)-alpha-(1-azabicyclo[2.2.2.]oct-3-yl)acetonitrile monohydrochloride
|
|
US5834458A
(en)
|
1996-10-09 |
1998-11-10 |
Eli Lilly And Company |
Heterocyclic compounds and their use
|
|
WO1998016528A1
(en)
|
1996-10-11 |
1998-04-23 |
Chiron Corporation |
Purine inhibitors of glycogen synthase kinase 3 (gsk3)
|
|
DE19642451A1
(de)
|
1996-10-15 |
1998-04-16 |
Merck Patent Gmbh |
Aminothiophencarbonsäureamide
|
|
GB9621789D0
(en)
|
1996-10-18 |
1996-12-11 |
Lilly Industries Ltd |
Pharmaceutical compounds
|
|
NZ334868A
(en)
|
1996-10-21 |
2001-02-23 |
Neurosearch As |
1-Phenyl-benzimidazole compounds and their use as BAGA-a receptor modulators
|
|
GB9622386D0
(en)
|
1996-10-28 |
1997-01-08 |
Sandoz Ltd |
Organic compounds
|
|
US5773458A
(en)
|
1996-10-30 |
1998-06-30 |
American Home Products Corporation |
1-azabicycloheptane derivatives
|
|
US6331543B1
(en)
|
1996-11-01 |
2001-12-18 |
Nitromed, Inc. |
Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
|
|
US6069151A
(en)
|
1996-11-06 |
2000-05-30 |
Darwin Discovery, Ltd. |
Quinolines and their therapeutic use
|
|
JP2001504462A
(ja)
|
1996-11-12 |
2001-04-03 |
ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング |
ホスホジエステラーゼ阻害剤としての（２，３―ジヒドロベンゾフラニル）―チアゾール
|
|
SI0941221T1
(en)
|
1996-11-20 |
2003-10-31 |
Altana Pharma Ag |
Substituted dihydrobenzofurans as pde inhibitors
|
|
GB9625184D0
(en)
|
1996-12-04 |
1997-01-22 |
Celltech Therapeutics Ltd |
Chemical compounds
|
|
ES2193508T3
(es)
|
1997-01-15 |
2003-11-01 |
Altana Pharma Ag |
Ftalizinonas.
|
|
GB9702524D0
(en)
|
1997-02-07 |
1997-03-26 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
DK0975347T3
(da)
|
1997-02-28 |
2008-06-16 |
Nycomed Gmbh |
Synergistisk kombination af PDE-inhibitorer og adenylatcyclase-agonister eller guanylcyclyseagonister
|
|
ES2131463B1
(es)
|
1997-04-08 |
2000-03-01 |
Lilly Sa |
Derivados de ciclopropilglicina con propiedades farmaceuticas.
|
|
US6387673B1
(en)
|
1997-05-01 |
2002-05-14 |
The Salk Institute For Biological Studies |
Compounds useful for the modulation of processes mediated by nuclear hormone receptors, methods for the identification and use of such compounds
|
|
GB9708945D0
(en)
|
1997-05-01 |
1997-06-25 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US6043252A
(en)
|
1997-05-05 |
2000-03-28 |
Icos Corporation |
Carboline derivatives
|
|
ES2179490T3
(es)
|
1997-05-08 |
2003-01-16 |
Merck Sharp & Dohme |
Derivados de 1,2,4-triazolo(3,4-a)ftalazina sustituidos como ligandos de gaba alfa 5.
|
|
ZA983930B
(en)
|
1997-05-14 |
1999-11-08 |
Lilly Co Eli |
Excitatory amino acid receptor modulators.
|
|
WO1998053820A1
(en)
|
1997-05-29 |
1998-12-03 |
H. Lundbeck A/S |
Treatment of schizophrenia and psychosis
|
|
WO1999003822A1
(en)
|
1997-07-18 |
1999-01-28 |
Georgetown University |
Bicyclic metabotropic glutamate receptor ligands
|
|
US6825211B1
(en)
|
1997-07-18 |
2004-11-30 |
Georgetown University |
Bicyclic metabotropic glutamate receptor ligands
|
|
ES2189235T3
(es)
|
1997-07-25 |
2003-07-01 |
Altana Pharma Ag |
6-fenilfenantridinas sustituidas.
|
|
ES2137113B1
(es)
|
1997-07-29 |
2000-09-16 |
Almirall Prodesfarma Sa |
Nuevos derivados de triazolo-piridazinas heterociclicos.
|
|
GB9715977D0
(en)
|
1997-07-29 |
1997-10-01 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US6107295A
(en)
|
1997-08-01 |
2000-08-22 |
Merck Patent Gesellschaft Mit Beschrankter Haftung |
Arylalkanoyl pyridazines
|
|
CA2268190A1
(en)
|
1997-08-06 |
1999-02-18 |
Suntory Limited |
1-aryl-1,8-naphthylidin-4-one derivative as type iv phosphodiesterase inhibitor
|
|
US6143760A
(en)
|
1997-08-25 |
2000-11-07 |
Neurogen Corporation |
Substituted 4-oxo-napthyridine-3-carboxamides: GABA brain receptor ligands
|
|
US6207842B1
(en)
|
1997-10-09 |
2001-03-27 |
Mars Incorporated |
Process for preparing procyanidin(4-6 or 4-8) oligomers and their derivatives
|
|
US6156753A
(en)
|
1997-10-28 |
2000-12-05 |
Vivus, Inc. |
Local administration of type III phosphodiesterase inhibitors for the treatment of erectile dysfunction
|
|
US6127363A
(en)
|
1997-10-28 |
2000-10-03 |
Vivus, Inc. |
Local administration of Type IV phosphodiesterase inhibitors for the treatment of erectile dysfunction
|
|
UA64769C2
(uk)
|
1997-11-07 |
2004-03-15 |
Х. Луннбек А/С |
Гідрогалогеніди 1'-[4-[1-(4-фторофеніл)-1н-індол-3-іл]-1-бутил]-спіро[ізобензофуран-1(3н),4'-піперидину], фармацевтична композиція та спосіб лікування
|
|
TR200001338T2
(tr)
|
1997-11-12 |
2000-08-21 |
Bayer Aktiengesellschaft |
2-Fenil-ikameli imidazotriazinonlar
|
|
US6429207B1
(en)
|
1997-11-21 |
2002-08-06 |
Nps Pharmaceuticals, Inc. |
Metabotropic glutamate receptor antagonists and their use for treating central nervous system diseases
|
|
US6040447A
(en)
|
1997-12-12 |
2000-03-21 |
Euro-Celtique S.A. |
Purine compounds having PDE IV inhibitory activity and methods of synthesis
|
|
IT1296985B1
(it)
|
1997-12-19 |
1999-08-03 |
Zambon Spa |
Derivati benzazinici inibitori della fosfodiesterasi 4
|
|
EP1047697A1
(en)
|
1998-01-14 |
2000-11-02 |
MERCK SHARP & DOHME LTD. |
Triazolo-pyridazine derivatives as ligands for gaba receptors
|
|
GB9801234D0
(en)
|
1998-01-21 |
1998-03-18 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
AU748737B2
(en)
|
1998-01-21 |
2002-06-13 |
Merck Sharp & Dohme Limited |
Triazolo-pyridazine derivatives as ligands for GABA receptors
|
|
GB9801202D0
(en)
|
1998-01-21 |
1998-03-18 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB9801210D0
(en)
|
1998-01-21 |
1998-03-18 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB9801208D0
(en)
|
1998-01-21 |
1998-03-18 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB9801397D0
(en)
|
1998-01-22 |
1998-03-18 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
KR20010005830A
(ko)
|
1998-01-29 |
2001-01-15 |
도리이 신이치로 |
타입 ⅳ 포스포디에스테라제 억제활성을 지닌 1-사이클로알킬-1,8-나프틸리딘-4-온 유도체
|
|
US6166203A
(en)
|
1998-02-26 |
2000-12-26 |
Neurogen Corporation |
Heterocyclic amino substituted heteroaryl fused pyridines; GABA brain receptor ligands
|
|
AU2881199A
(en)
|
1998-02-26 |
1999-09-15 |
Neurogen Corporation |
Substituted 1,4-dihydro-4-oxonicotinic carboxamides: gaba brain receptor ligands
|
|
WO1999043681A1
(en)
|
1998-02-26 |
1999-09-02 |
Neurogen Corporation |
4-(4-piperidylmethylamino) substituted heteroaryl fused pyridines: gaba brain receptor ligands
|
|
CA2322167A1
(en)
|
1998-02-26 |
1999-09-02 |
Neurogen Corporation |
Substituted cycloalkyl-4-oxonicotinic carboxamides; gaba brain receptor ligands
|
|
US6900228B1
(en)
|
1998-03-10 |
2005-05-31 |
Research Triangle Institute |
Opiate compounds, methods of making and methods of use
|
|
US6805883B2
(en)
|
1998-03-12 |
2004-10-19 |
Mars, Incorporated |
Food products containing polyphenol(s) and L-arginine to stimulate nitric oxide
|
|
GB9806102D0
(en)
|
1998-03-20 |
1998-05-20 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
FR2776660B1
(fr)
|
1998-03-27 |
2000-05-12 |
Parke Davis |
Diazepino-indoles de phosphodiesterases iv
|
|
US6528529B1
(en)
|
1998-03-31 |
2003-03-04 |
Acadia Pharmaceuticals Inc. |
Compounds with activity on muscarinic receptors
|
|
JP2002512214A
(ja)
|
1998-04-17 |
2002-04-23 |
ケネス カリー， |
代謝生成物産生グルタミン酸レセプターアンタゴニストとしてのキュバン誘導体およびそれらの調製プロセス
|
|
EP1371647B1
(en)
|
1998-04-20 |
2005-07-13 |
Pfizer Inc. |
Pyridine-3-carboxylic acid derivatives and their use as intermediates
|
|
DE59913617D1
(de)
|
1998-04-28 |
2006-08-03 |
Elbion Ag |
Indolderivate und deren Verwendung als Inhibitoren der Phosphodiesterase 4.
|
|
US6897305B2
(en)
|
1998-06-08 |
2005-05-24 |
Theravance, Inc. |
Calcium channel drugs and uses
|
|
US6303789B1
(en)
|
1998-06-10 |
2001-10-16 |
Byk Gulden Lomberg Chemische Fabrik Gmbh |
Benzamides with tetrahydrofuranyloxy substitutents as phosphodiesterase 4 inhibitors
|
|
GB9813006D0
(en)
|
1998-06-16 |
1998-08-12 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
JP2002518391A
(ja)
|
1998-06-16 |
2002-06-25 |
メルク シャープ エンド ドーム リミテッド |
Ｇａｂａ受容体のリガンドとしてのトリアゾロ−ピリジン誘導体
|
|
US6417185B1
(en)
|
1998-06-19 |
2002-07-09 |
Chiron Corporation |
Inhibitors of glycogen synthase kinase 3
|
|
CA2336894A1
(en)
|
1998-07-06 |
2000-01-13 |
Byk Gulden Lomberg Chemische Fabrik Gmbh |
New benzoxazoles with pde-inhibiting activity
|
|
ITMI981671A1
(it)
|
1998-07-21 |
2000-01-21 |
Zambon Spa |
Derivati ftalazinici inibitori della fosfodisterasi 4
|
|
US6177569B1
(en)
|
1998-08-25 |
2001-01-23 |
Neurogen Corporation |
Oxo-pyridoimidazole-carboxamides: GABA brain receptor ligands
|
|
DK1110943T3
(da)
|
1998-08-31 |
2004-10-11 |
Taisho Pharmaceutical Co Ltd |
6-fluorbicyclo[3.1.0]hexanderivater
|
|
CH694053A5
(de)
|
1998-09-03 |
2004-06-30 |
Hoffmann La Roche |
Verfahren zur Herstellung von 2-Amino-bicyclo[3.1.0]hexan-2,6-dicarbonsäure-Derivaten.
|
|
KR20010073099A
(ko)
|
1998-09-03 |
2001-07-31 |
히라타 다다시 |
함산소 복소환 화합물
|
|
CA2339630C
(en)
|
1998-09-16 |
2006-05-23 |
Icos Corporation |
Carboline derivatives as cgmp phosphodiesterase inhibitors
|
|
US6719520B2
(en)
|
1998-10-08 |
2004-04-13 |
Smithkline Beecham Corporation |
Method and compounds
|
|
AU760688B2
(en)
|
1998-10-16 |
2003-05-22 |
Merck Sharp & Dohme Limited |
Pyrazolo-triazine derivatives as ligands for GABA receptors
|
|
WO2000027849A2
(en)
|
1998-11-12 |
2000-05-18 |
Merck & Co., Inc. |
Therapeutic polymorphs of a gaba-a alpha-5 inverse agonist and pamoate formulations of the same
|
|
PE20001236A1
(es)
|
1998-11-13 |
2000-11-10 |
Lilly Co Eli |
Moduladores del receptor de aminoacidos excitadores
|
|
SE9804064D0
(sv)
|
1998-11-25 |
1998-11-25 |
A & Science Invest Ab |
Medicinal product and method for treatment of conditions affecting neural stem cells or progenitor cells
|
|
US6130333A
(en)
|
1998-11-27 |
2000-10-10 |
Monsanto Company |
Bicyclic imidazolyl derivatives as phosphodiesterase inhibitors, pharmaceutical compositions and method of use
|
|
WO2000037471A1
(en)
|
1998-12-23 |
2000-06-29 |
Neurogen Corporation |
2-amino-9-alkylpurines: gaba brain receptor ligands
|
|
EP1149102B1
(en)
|
1999-01-27 |
2004-12-08 |
MERCK SHARP & DOHME LTD. |
Triazolo-pyridazine derivatives as ligands for gaba receptors
|
|
US6342496B1
(en)
|
1999-03-01 |
2002-01-29 |
Sepracor Inc. |
Bupropion metabolites and methods of use
|
|
US6498176B1
(en)
|
1999-03-04 |
2002-12-24 |
Smithklinebeecham Corporation |
3-(anilinomethylene) oxindoles as protein tyrosine kinase and protein serine/threonine kinase inhibitors
|
|
TW575561B
(en)
|
1999-03-25 |
2004-02-11 |
Hoffmann La Roche |
1-arenesulfonyl-2-aryl-pyrrolidine and piperidine derivatives
|
|
US6479470B1
(en)
|
1999-04-28 |
2002-11-12 |
Georgetown University |
Ligands for metabotropic glutamate receptors and inhibitors of NAALAdase
|
|
US6528499B1
(en)
|
2000-04-27 |
2003-03-04 |
Georgetown University |
Ligands for metabotropic glutamate receptors and inhibitors of NAALADase
|
|
FR2792938B1
(fr)
|
1999-04-28 |
2001-07-06 |
Warner Lambert Co |
NOUVELLES 1-AMINO TRIAZOLO [4,3-a] QUINAZOLINE-5-ONES INHIBITRICES DE PHOSPHODIESTERASES IV
|
|
US6943166B1
(en)
|
1999-04-30 |
2005-09-13 |
Lilly Icos Llc. |
Compositions comprising phosphodiesterase inhabitors for the treatment of sexual disfunction
|
|
US6316472B1
(en)
|
1999-05-13 |
2001-11-13 |
Merck Frosst Canada & Co. |
Heterosubstituted pyridine derivatives as PDE 4 inhibitors
|
|
US6448246B1
(en)
|
1999-05-25 |
2002-09-10 |
Neurogen Corporation |
Substituted 4H-1,4-benzothiazine-2-carboxamide: GABA brain receptor ligands
|
|
WO2000075101A1
(en)
|
1999-06-03 |
2000-12-14 |
Lilly, S.A. |
Excitatory amino acid receptor modulators
|
|
WO2000077045A1
(fr)
|
1999-06-10 |
2000-12-21 |
Takeda Chemical Industries, Ltd. |
Proteine et adn de cette proteine
|
|
US6146876A
(en)
|
1999-06-11 |
2000-11-14 |
Millennium Pharmaceuticals, Inc. |
22025, a novel human cyclic nucleotide phosphodiesterase
|
|
US6297256B1
(en)
|
1999-06-15 |
2001-10-02 |
Neurogen Corporation |
Aryl and heteroaryl substituted pyridino derivatives GABA brain receptor ligands
|
|
DE19928146A1
(de)
|
1999-06-19 |
2000-12-21 |
Merck Patent Gmbh |
Thienopyrimidine
|
|
CZ2002233A3
(cs)
|
1999-07-21 |
2002-04-17 |
Fujisawa Pharmaceutical Co., Ltd. |
Benzimidazolonové deriváty, způsob jejich výroby a farmaceutický prostředek
|
|
US6821975B1
(en)
|
1999-08-03 |
2004-11-23 |
Lilly Icos Llc |
Beta-carboline drug products
|
|
DE60006618T2
(de)
|
1999-08-06 |
2004-09-23 |
F. Hoffmann-La Roche Ag |
Tetrahydro-benzo(d)azepine und deren Verwendung als metabotrope Glutamatrezeptor-Antagonisten
|
|
US6476019B1
(en)
|
1999-08-13 |
2002-11-05 |
Sepracor Inc. |
Spirocyclic ligands for sigma receptors, and libraries and methods of use thereof
|
|
US6660753B2
(en)
|
1999-08-19 |
2003-12-09 |
Nps Pharmaceuticals, Inc. |
Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
|
|
US6313159B1
(en)
|
1999-08-20 |
2001-11-06 |
Guilford Pharmaceuticals Inc. |
Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors
|
|
GB9919957D0
(en)
|
1999-08-23 |
1999-10-27 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US20050014939A1
(en)
|
1999-08-31 |
2005-01-20 |
Neurogen Corporation |
Fused pyrrolecarboxamides: GABA brain receptor ligands
|
|
US6956049B1
(en)
|
1999-08-31 |
2005-10-18 |
Merck & Co., Inc. |
Methods of modulating processes mediated by excitatory amino acid receptors
|
|
GB9921150D0
(en)
|
1999-09-07 |
1999-11-10 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB9921351D0
(en)
|
1999-09-09 |
1999-11-10 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
TWI265925B
(en)
|
1999-10-11 |
2006-11-11 |
Pfizer |
Pyrazolo[4,3-d]pyrimidin-7-ones useful in inhibiting type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterases(cGMP PDE5), process and intermediates for their preparation, their uses and composition comprising them
|
|
US6552016B1
(en)
|
1999-10-14 |
2003-04-22 |
Curis, Inc. |
Mediators of hedgehog signaling pathways, compositions and uses related thereto
|
|
MXPA02003740A
(es)
|
1999-10-15 |
2002-09-30 |
Hoffmann La Roche |
Derivados de benzodiazepina.
|
|
US7491742B2
(en)
|
1999-10-21 |
2009-02-17 |
Merck Patent Gmbh |
Imidazole derivatives as phosphodiesterase VII inhibitors
|
|
US6534287B1
(en)
|
1999-10-25 |
2003-03-18 |
Nps Pharmaceuticals, Inc. |
Human metabotropic glutamate receptor
|
|
AR029185A1
(es)
|
1999-10-25 |
2003-06-18 |
Yamanouchi Pharma Co Ltd |
Derivado de naftiridina
|
|
DE19953025A1
(de)
|
1999-11-04 |
2001-05-10 |
Merck Patent Gmbh |
Pyrrolderivate als Phosphodiesterase VII-Hemmer
|
|
DE19953414A1
(de)
|
1999-11-06 |
2001-05-10 |
Merck Patent Gmbh |
Imidazopyridinderivate als Phospodiesterase VII-Hemmer
|
|
DE19954707A1
(de)
|
1999-11-13 |
2001-05-17 |
Merck Patent Gmbh |
Imidazolverbindungen als Phosphodiesterase VII-Hemmer
|
|
GB9927687D0
(en)
|
1999-11-23 |
2000-01-19 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
CA2391952C
(en)
|
1999-11-23 |
2012-01-31 |
Methylgene Inc. |
Inhibitors of histone deacetylase
|
|
JP4825387B2
(ja)
|
1999-12-08 |
2011-11-30 |
あすか製薬株式会社 |
新規な１，８−ナフチリジン−２（１ｈ）−オン誘導体
|
|
ES2213996T3
(es)
|
1999-12-08 |
2004-09-01 |
Centre National De La Recherche Scientifique (Cnrs) |
Uso de himenialdisina o sus derivados en la fabricacion de medicamentos.
|
|
GB9929687D0
(en)
|
1999-12-15 |
2000-02-09 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US6376489B1
(en)
|
1999-12-23 |
2002-04-23 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
US6680336B2
(en)
|
1999-12-15 |
2004-01-20 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
GB9929685D0
(en)
|
1999-12-15 |
2000-02-09 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
CN100335479C
(zh)
|
1999-12-17 |
2007-09-05 |
希龙公司 |
糖元合成酶激酶3的双环抑制剂
|
|
US6362213B1
(en)
|
1999-12-23 |
2002-03-26 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
US6313156B1
(en)
|
1999-12-23 |
2001-11-06 |
Icos Corporation |
Thiazole compounds as cyclic-AMP-specific phosphodiesterase inhibitors
|
|
US6569885B1
(en)
|
1999-12-23 |
2003-05-27 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
US6294561B1
(en)
|
1999-12-23 |
2001-09-25 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
US6258833B1
(en)
|
1999-12-23 |
2001-07-10 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
US6372777B1
(en)
|
1999-12-23 |
2002-04-16 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
US6348602B1
(en)
|
1999-12-23 |
2002-02-19 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
|
GB0000564D0
(en)
|
2000-01-11 |
2000-03-01 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
AU2700301A
(en)
|
2000-01-31 |
2001-08-14 |
Pfizer Products Inc. |
Pyrimidine carboxamides useful as inhibitors of pde4 isozymes
|
|
JP2003523741A
(ja)
|
2000-02-01 |
2003-08-12 |
ヒューマン ジノーム サイエンシーズ， インコーポレイテッド |
Ｂｃｌ−２様ポリヌクレオチド、ポリペプチドおよび抗体
|
|
US6800651B2
(en)
|
2000-02-03 |
2004-10-05 |
Eli Lilly And Company |
Potentiators of glutamate receptors
|
|
US20010039275A1
(en)
|
2000-02-04 |
2001-11-08 |
Bowler Andrew Neil |
Use of 2,4-diaminothiazole derivatives
|
|
US20010034373A1
(en)
*
|
2000-02-09 |
2001-10-25 |
Matthew Miller |
Low dose modafinil for enhancement of cognitive function
|
|
GB0003254D0
(en)
|
2000-02-11 |
2000-04-05 |
Darwin Discovery Ltd |
Heterocyclic compounds and their therapeutic use
|
|
FR2804959B1
(fr)
|
2000-02-15 |
2006-04-28 |
Centre Nat Rech Scient |
Utilisation de derives de paullones pour la fabrication de medicaments
|
|
IL151533A0
(en)
|
2000-02-29 |
2003-04-10 |
Mitsubishi Pharma Corp |
Novel cyclic amide derivatives
|
|
GB0005700D0
(en)
|
2000-03-09 |
2000-05-03 |
Glaxo Group Ltd |
Therapy
|
|
AU2001250892A1
(en)
|
2000-03-20 |
2001-10-03 |
Teva Pharmaceutical Industries Ltd. |
Processes for preparing 6-hydroxy-3,4-dihydroquinolinone, cilostazol and n-(4-methoxyphenyl)-3-chloropropionamide
|
|
DE60125026T2
(de)
|
2000-03-23 |
2007-06-28 |
Takeda Pharmaceutical Co. Ltd. |
Fluorisochinolinderivate, verfahren zu ihrer herstellung und ihre anwendung
|
|
AU2001248701A1
(en)
|
2000-03-24 |
2001-10-03 |
Methylgene, Inc. |
Inhibitors of histone deacetylase
|
|
GB0007193D0
(en)
|
2000-03-25 |
2000-05-17 |
Univ Manchester |
Treatment of movrmrnt disorders
|
|
GB0008696D0
(en)
|
2000-04-07 |
2000-05-31 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
PL357822A1
(pl)
|
2000-04-14 |
2004-07-26 |
Mars Incorporated |
Kompozycje i sposoby polepszania stanu zdrowia układu naczyniowego
|
|
CA2306170A1
(en)
|
2000-04-18 |
2001-10-18 |
Kenneth Curry |
Novel amino, carboxy derivatives of barbituric acid
|
|
RU2269523C2
(ru)
|
2000-04-28 |
2006-02-10 |
Акадиа Фармасьютикалз, Инк. |
Мускариновые агонисты
|
|
CA2408747C
(en)
|
2000-05-11 |
2011-04-05 |
Consejo Superior Investigaciones Cientificas |
Heterocyclic inhibitors of glycogen synthase kinase gsk-3
|
|
US20040077599A1
(en)
|
2000-05-11 |
2004-04-22 |
Kenneth Curry |
Novel spiro[2.4]heptane amino carboxy compounds and derivatives thereof
|
|
UA74826C2
(en)
|
2000-05-17 |
2006-02-15 |
Ortho Mcneil Pharm Inc |
?-carboline derivatives as phosphodiesterase inhibitors
|
|
UA72611C2
(uk)
|
2000-05-17 |
2005-03-15 |
Орто-Макнейл Фармацевтикал, Інк. |
Похідні заміщеного піролопіридинону, корисні як інгібітори фосфодіестерази
|
|
EP1294723A1
(en)
|
2000-05-24 |
2003-03-26 |
MERCK SHARP & DOHME LTD. |
3-phenyl-imidazo-pyrimidine derivatives as ligands for gaba receptors
|
|
EP1289383B1
(fr)
|
2000-05-30 |
2006-05-03 |
Societe Des Produits Nestle S.A. |
Composition primaire contenant un compose bioactif lipophile
|
|
US7081481B2
(en)
|
2000-05-31 |
2006-07-25 |
Eli Lilly And Company |
Excitatory amino acid receptor modulators
|
|
AU2001281802A1
(en)
|
2000-06-07 |
2001-12-17 |
Almirall Prodesfarma, S.A. |
6-phenylpyrrolopyrimidinedione derivatives
|
|
CA2412596C
(en)
|
2000-06-23 |
2007-07-31 |
Lilly Icos Llc |
Cyclic gmp-specific phosphodiesterase inhibitors
|
|
US6589978B2
(en)
|
2000-06-30 |
2003-07-08 |
Hoffman-La Roche Inc. |
1-sulfonyl pyrrolidine derivatives
|
|
US6399641B1
(en)
|
2000-07-13 |
2002-06-04 |
Hoffmann-La Roche Inc. |
2H-tetrazole-amide compounds with therapeutic activity as metabotropic glutamate receptor agonists
|
|
GB0018473D0
(en)
|
2000-07-27 |
2000-09-13 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
WO2002009713A2
(de)
|
2000-08-01 |
2002-02-07 |
Bayer Aktiengesellschaft |
Selektive pde 2-inhibitoren als arzneimittel zur verbesserung der wahrnehmung
|
|
US6645990B2
(en)
|
2000-08-15 |
2003-11-11 |
Amgen Inc. |
Thiazolyl urea compounds and methods of uses
|
|
IL154425A0
(en)
|
2000-08-24 |
2003-09-17 |
Univ Tennessee Res H Corp |
Selective androgen receptor modulators and methods of use thereof
|
|
PE20020354A1
(es)
|
2000-09-01 |
2002-06-12 |
Novartis Ag |
Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
|
|
US6576644B2
(en)
|
2000-09-06 |
2003-06-10 |
Bristol-Myers Squibb Co. |
Quinoline inhibitors of cGMP phosphodiesterase
|
|
WO2002022579A2
(en)
|
2000-09-11 |
2002-03-21 |
Sepracor, Inc. |
Antipsychotic sulfonamide-heterocycles, and methods of use thereof
|
|
US6610677B2
(en)
|
2000-09-15 |
2003-08-26 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
ES2266258T3
(es)
|
2000-09-15 |
2007-03-01 |
Vertex Pharmaceuticals Incorporated |
Compuestos de pirazol utiles como inhibidores de proteina cinasas.
|
|
US6613776B2
(en)
|
2000-09-15 |
2003-09-02 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
JP4975941B2
(ja)
|
2000-09-29 |
2012-07-11 |
トポターゲット ユーケー リミテッド |
（ｅ）−ｎ−ヒドロキシ−３−（３−スルファモイル−フェニル）アクリルアミド化合物及びその治療用途
|
|
WO2002026696A1
(en)
|
2000-09-29 |
2002-04-04 |
Prolifix Limited |
Carbamic acid compounds comprising an amide linkage as hdac inhibitors
|
|
GB0023983D0
(en)
|
2000-09-29 |
2000-11-15 |
Prolifix Ltd |
Therapeutic compounds
|
|
EP1193261A1
(en)
|
2000-10-02 |
2002-04-03 |
Warner-Lambert Company |
New thiadiazoles and their use as phosphodiesterase-7 inhibitors
|
|
IL155163A0
(en)
|
2000-10-02 |
2003-10-31 |
Janssen Pharmaceutica Nv |
Metabotropic glutamate receptor antagonists
|
|
US20020103192A1
(en)
|
2000-10-26 |
2002-08-01 |
Curtin Michael L. |
Inhibitors of histone deacetylase
|
|
GB0117277D0
(en)
|
2001-07-16 |
2001-09-05 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
ATE310740T1
(de)
|
2000-11-10 |
2005-12-15 |
Merck Sharp & Dohme |
Imidazotriazin-derivate als liganden für gaba- rezeptoren
|
|
GB0027561D0
(en)
|
2000-11-10 |
2000-12-27 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
AU2002229541B2
(en)
|
2000-11-14 |
2007-01-18 |
Altana Pharma Ag |
(dihydro)isoquinoline derivatives as phosphodiesterase inhibitors
|
|
AR035659A1
(es)
|
2000-12-07 |
2004-06-23 |
Hoffmann La Roche |
Hidroxiamidas de acido (1-oxo-1,2,3,4-tetrahidro-naftalen-2-il)-alcanoico, proceso para la manufactura de estos compuestos, composiciones farmaceuticas que contienen dichos compuestos y los usos de los mismos
|
|
JP2004517843A
(ja)
|
2000-12-13 |
2004-06-17 |
バイエル アクチェンゲゼルシャフト |
ピロロ［２．１−ａ］ジヒドロイソキノリンおよびホスホジエステラーゼ１０ａ阻害薬としてのその使用
|
|
US6900215B2
(en)
|
2000-12-15 |
2005-05-31 |
Merck Sharp & Dohme Ltd. |
Imidazo-pyrimidine derivatives as ligands for gaba receptors
|
|
US6562995B1
(en)
|
2000-12-21 |
2003-05-13 |
Beacon Laboratories, Inc. |
Delta dicarbonyl compounds and methods for using the same
|
|
EP1345925B1
(en)
|
2000-12-21 |
2006-05-17 |
Vertex Pharmaceuticals Incorporated |
Pyrazole compounds useful as protein kinase inhibitors
|
|
US6720445B2
(en)
|
2000-12-21 |
2004-04-13 |
Beacon Laboratories, Inc. |
Acetyloxymethyl esters and methods for using the same
|
|
CA2432077C
(en)
|
2000-12-22 |
2011-01-18 |
F. Hoffmann-La Roche Ag |
Tetrahydro-(benzo or thieno)-azepine-pyrazine and triazine derivatives as mglur 1 antagonists
|
|
AR035513A1
(es)
|
2000-12-23 |
2004-06-02 |
Hoffmann La Roche |
Derivados de tetrahidropiridina, proceso para prepararlos, composiciones farmaceuticas que los contienen, y uso de dichos compuestos en la preparacion de medicamentos
|
|
GR1003861B
(el)
|
2000-12-29 |
2002-04-11 |
|
Νεα νευροστεροειδη που αλληλεπιδρουν με τον υποδοχεα gabaa.
|
|
US6974824B2
(en)
|
2001-01-08 |
2005-12-13 |
Research Triangle Institute |
Kappa opioid receptor ligands
|
|
AR035417A1
(es)
|
2001-01-27 |
2004-05-26 |
Hoffmann La Roche |
Derivados triciclicos de lactama y sultama, procesos para su elaboracion, medicamentos que los contienen, y el uso de dichos compuestos en la preparacion de medicamentos
|
|
KR20030070150A
(ko)
|
2001-01-31 |
2003-08-27 |
화이자 프로덕츠 인크. |
Ｐｄｅ4 이소자임 억제제로서 유용한 에테르 유도체
|
|
JP2004520386A
(ja)
|
2001-01-31 |
2004-07-08 |
ファイザー・プロダクツ・インク |
Ｐｄｅ４アイソザイムの阻害剤として有用なニコチンアミドビアリール誘導体
|
|
OA12542A
(en)
|
2001-01-31 |
2006-06-05 |
Pfizer Prod Inc |
Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of PDE4isozymes.
|
|
US6559159B2
(en)
|
2001-02-01 |
2003-05-06 |
Research Triangle Institute |
Kappa opioid receptor ligands
|
|
US6617357B2
(en)
|
2001-03-06 |
2003-09-09 |
Smithkline Beecham Corporation |
Compounds and their use as PDE inhibitors
|
|
US20020177594A1
(en)
|
2001-03-14 |
2002-11-28 |
Curtin Michael L. |
Inhibitors of histone deacetylase
|
|
US6900329B2
(en)
|
2001-03-21 |
2005-05-31 |
Schering Corporation |
MCH antagonists and their use in the treatment of obesity
|
|
AP1699A
(en)
|
2001-03-21 |
2006-12-26 |
Warner Lambert Co |
New spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors
|
|
DE60238674D1
(de)
|
2001-04-19 |
2011-02-03 |
Mitsubishi Tanabe Pharma Corp |
Polymorphe formen von n-(2,3-dimethyl-5,6,7,8-tetrahydrofuro(2,3-b)quinolin-4-yl)-2-(2-oxopyrrolidin-1 -yl)acetamid
|
|
WO2002088079A2
(en)
|
2001-05-01 |
2002-11-07 |
Bristol-Myers Squibb Company |
Dual inhibitors of pde 7 and pde 4
|
|
GB0111191D0
(en)
|
2001-05-08 |
2001-06-27 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
AU2002305523A1
(en)
|
2001-05-09 |
2002-11-18 |
President And Fellows Of Harvard College |
Dioxanes and uses thereof
|
|
MXPA03010961A
(es)
|
2001-05-31 |
2004-02-27 |
Vertex Pharma |
Compuestos de tiazol utiles como inhibidores de proteinas cinasas.
|
|
CA2450271A1
(en)
|
2001-06-12 |
2002-12-19 |
Sk Corporation |
Novel phenylalkyl diamine and amide analogs
|
|
WO2002102313A2
(en)
|
2001-06-19 |
2002-12-27 |
Bristol-Myers Squibb Company |
Pyrimidine inhibitors of phosphodiesterase (pde) 7
|
|
PE20030008A1
(es)
|
2001-06-19 |
2003-01-22 |
Bristol Myers Squibb Co |
Inhibidores duales de pde 7 y pde 4
|
|
DE10130167A1
(de)
|
2001-06-22 |
2003-01-02 |
Bayer Ag |
Imidazotriazine
|
|
GB0117060D0
(en)
|
2001-07-12 |
2001-09-05 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US20040235884A1
(en)
|
2001-08-06 |
2004-11-25 |
Ken Takashina |
Preventives/remedies for cholinergic neuropathy
|
|
EP1285922A1
(en)
|
2001-08-13 |
2003-02-26 |
Warner-Lambert Company |
1-Alkyl or 1-cycloalkyltriazolo[4,3-a]quinazolin-5-ones as phosphodiesterase inhibitors
|
|
JO2311B1
(en)
|
2001-08-29 |
2005-09-12 |
ميرك فروست كندا ليمتد |
Alkyl inhibitors Ariel phosphodiesterase-4
|
|
US6897220B2
(en)
|
2001-09-14 |
2005-05-24 |
Methylgene, Inc. |
Inhibitors of histone deacetylase
|
|
WO2003024448A2
(en)
|
2001-09-14 |
2003-03-27 |
Methylgene, Inc. |
Inhibitors of histone deacetylase
|
|
EP1295885A1
(en)
|
2001-09-21 |
2003-03-26 |
Sanofi-Synthelabo |
Substituted 2-pyridinyl-6,7,8,9-tetrahydropyrimido(1,2-a)pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo(1,2-a)pyrimidin-5(1H)one derivatives
|
|
EP1295884A1
(en)
|
2001-09-21 |
2003-03-26 |
Sanofi-Synthelabo |
2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]Pyrimidin-4-one and 7-Pyrimidinyl-2,3-Dihydroimidazo[1,2-a]Pyrimidin-5(1H)one derivatives
|
|
RU2004112787A
(ru)
|
2001-09-26 |
2005-10-10 |
Байер Фармасьютикалс Корпорейшн (US) |
Производные 1,6-нафтиридина как противодиабетические средства
|
|
US6951849B2
(en)
|
2001-10-02 |
2005-10-04 |
Acadia Pharmaceuticals Inc. |
Benzimidazolidinone derivatives as muscarinic agents
|
|
WO2003028650A2
(en)
|
2001-10-02 |
2003-04-10 |
Acadia Pharmaceuticals, Inc. |
Benzimidazolidinone derivatives as muscarinic agents
|
|
US6924311B2
(en)
|
2001-10-17 |
2005-08-02 |
X-Ceptor Therapeutics, Inc. |
Methods for affecting various diseases utilizing LXR compounds
|
|
EP1443922A1
(en)
|
2001-10-25 |
2004-08-11 |
Schering Corporation |
Mch antagonists for the treatment of obesity
|
|
CN1582277A
(zh)
|
2001-11-01 |
2005-02-16 |
詹森药业有限公司 |
用作糖原合酶激酶3β抑制剂的酰胺衍生物
|
|
MXPA04004178A
(es)
|
2001-11-01 |
2004-09-06 |
Janssen Pharmaceutica Nv |
Heteroarilaminas como inhibidores de glucogeno cintasa cinasa 3beta.
|
|
CA2467269C
(en)
|
2001-11-14 |
2011-04-05 |
Weiqin Jiang |
Substituted tetracyclic pyrroloquinolone derivatives useful as phosphodiesterase inhibitors
|
|
FR2832711B1
(fr)
|
2001-11-26 |
2004-01-30 |
Warner Lambert Co |
Derives de triazolo [4,3-a] pyrido [2,3-d] pyrimidin-5-ones, compositions les contenant, procede de preparation et utilisation
|
|
AU2002365892A1
(en)
|
2001-11-30 |
2003-06-17 |
Merck & Co., Inc. |
Metabotropic glutamate receptor-5 modulators
|
|
WO2003053975A1
(en)
|
2001-12-13 |
2003-07-03 |
Daiichi Suntory Pharma Co., Ltd. |
Pyrazolopyrimidinone derivatives having pde7-inhibitory activity
|
|
ES2295441T3
(es)
|
2001-12-18 |
2008-04-16 |
MERCK & CO., INC. |
Moduladores de pirazol heteroaril sustituido de receptor 5 metabotropico de glutamato.
|
|
EP1458708B1
(en)
|
2001-12-18 |
2007-09-26 |
Merck & Co., Inc. |
Heteroaryl substituted triazole modulators of metabotropic glutamate receptor-5
|
|
EP1458385A4
(en)
|
2001-12-19 |
2005-12-21 |
Merck & Co Inc |
METABOTROPIC GLUTAMATE RECEPTOR 5-HETEROARYL-SUBSTITUTED IMIDAZOLE MODULATORS
|
|
EP1458710A4
(en)
|
2001-12-21 |
2005-04-20 |
Merck & Co Inc |
Heteroaryl substituted pyrrole modulators of metabotropic glutamate receptor-5
|
|
DE10163991A1
(de)
|
2001-12-24 |
2003-07-03 |
Merck Patent Gmbh |
Pyrrolo-pyrimidine
|
|
CA2366325A1
(en)
|
2001-12-27 |
2003-06-27 |
Todd Howley |
Method of forming turbine blade root
|
|
ATE405289T1
(de)
|
2001-12-27 |
2008-09-15 |
Taisho Pharmaceutical Co Ltd |
6-fluorobicyclo 3.1.0 hexan-derivate
|
|
US7550459B2
(en)
|
2001-12-28 |
2009-06-23 |
Acadia Pharmaceuticals, Inc. |
Tetrahydroquinoline analogues as muscarinic agonists
|
|
NZ533566A
(en)
|
2001-12-28 |
2007-03-30 |
Acadia Pharm Inc |
Tetrahydroquinoline analogues as muscarinic agonists
|
|
KR100974901B1
(ko)
|
2001-12-28 |
2010-08-10 |
아카디아 파마슈티칼스 인코포레이티드 |
모노아민 수용체 조정자로서의 스피로아자사이클릭 화합물
|
|
US6495700B1
(en)
|
2002-01-09 |
2002-12-17 |
Axonyx, Inc. |
Process for producing phenserine and its analog
|
|
EP1468684A4
(en)
|
2002-01-22 |
2008-02-27 |
Eisai R&D Man Co Ltd |
SIGMA RECEPTOR BINDING MOLECULE WITH INDANO DERIVATIVE
|
|
US7378428B2
(en)
|
2002-01-31 |
2008-05-27 |
Ono Pharmaceutical Co., Ltd. |
Nitrogen-containing bicyclic compounds and drugs containing the same as the active ingredient
|
|
PL372756A1
(en)
|
2002-02-11 |
2005-08-08 |
Pfizer Inc. |
Nicotinamide derivatives useful as pde4 inhibitors
|
|
CA2477117A1
(en)
|
2002-02-22 |
2003-08-28 |
Teijin Limited |
Pyrrolopyrimidine derivative
|
|
ATE486600T1
(de)
|
2002-03-12 |
2010-11-15 |
Merck Sharp & Dohme |
Di-aryl-substituierte tetrazol-modulatoren des metabotropen glutamat-rezeptors-5
|
|
AU2003218737B2
(en)
|
2002-03-13 |
2008-04-10 |
Janssen Pharmaceutica N.V. |
Inhibitors of histone deacetylase
|
|
ES2306880T3
(es)
|
2002-03-13 |
2008-11-16 |
Janssen Pharmaceutica Nv |
Derivados de sulfonilamino como inhibidores novedosos de la histona desacetilasa.
|
|
ATE395343T1
(de)
|
2002-03-13 |
2008-05-15 |
Janssen Pharmaceutica Nv |
Sulfonylderivate als histone-deacetylase- inhibitoren
|
|
EA007270B1
(ru)
|
2002-03-13 |
2006-08-25 |
Янссен Фармацевтика Н.В. |
Пиперазинил-, пиперидинил- и морфолинилпроизводные как новые ингибиторы гистондеацетилазы
|
|
ES2284739T3
(es)
|
2002-03-20 |
2007-11-16 |
Societe Des Produits Nestle S.A. |
Extracto de cacao con bajo contenido en grasa.
|
|
US7514107B2
(en)
|
2002-03-21 |
2009-04-07 |
Mars, Incorporated |
Treatment of diseases involving defective gap junctional communication
|
|
BR0308908A
(pt)
|
2002-04-03 |
2005-01-04 |
Topotarget Uk Ltd |
Composto, composição, uso de um composto, e, métodos para inibir a hdac em uma célula, para o tratamento de uma condição mediada pela hdac, de um condição proliferativa, de câncer e de psorìase
|
|
GB0210124D0
(en)
|
2002-05-02 |
2002-06-12 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
GB0212048D0
(en)
|
2002-05-24 |
2002-07-03 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
JP4916662B2
(ja)
|
2002-06-19 |
2012-04-18 |
ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ |
ホスホジエステラーゼ阻害剤として有用な置換２，４−ジヒドロ−ピロロ（３，４−ｂ）−キノリン−９−オン誘導体
|
|
CA2492907A1
(en)
|
2002-07-19 |
2004-01-29 |
Memory Pharmaceuticals Corporation |
Phosphodiesterase 4 inhibitors, including n-substituted aniline and diphenylamine analogs
|
|
EP1400244A1
(en)
|
2002-09-17 |
2004-03-24 |
Warner-Lambert Company LLC |
New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors
|
|
EP1572099A4
(en)
|
2002-10-04 |
2007-01-03 |
Univ California |
SCREENING AND THERAPEUTIC METHODS RELATED TO THE NEUROGENESIS
|
|
EP1556355A1
(en)
|
2002-10-21 |
2005-07-27 |
Chiron Corporation |
Inhibitors of glycogen synthase kinase 3
|
|
US6969702B2
(en)
|
2002-11-20 |
2005-11-29 |
Neuronova Ab |
Compounds and methods for increasing neurogenesis
|
|
DK1583541T3
(da)
|
2002-11-20 |
2011-04-11 |
Neuronova Ab |
Forbindelser og fremgangsmåder til at øge neurogenese
|
|
ES2209650B2
(es)
|
2002-12-09 |
2006-11-01 |
Laboratorios Del Dr. Esteve, S.A. |
Mamiferos no humanos mutantes deficientes en receptores sigma y sus aplicaciones.
|
|
WO2004053071A2
(en)
|
2002-12-09 |
2004-06-24 |
Judith Kelleher-Andersson |
Method for discovering neurogenic agents
|
|
CA2512765A1
(en)
*
|
2003-01-08 |
2004-07-29 |
Mitsubishi Pharma Corporation |
Therapeutic agent for schizophrenia
|
|
TW200418806A
(en)
|
2003-01-13 |
2004-10-01 |
Fujisawa Pharmaceutical Co |
HDAC inhibitor
|
|
MXPA05008186A
(es)
|
2003-01-31 |
2005-10-05 |
Astrazeneca Ab |
Derivados de quinoxalina saturados y su uso como ligandos receptores de glutamato metabotropico.
|
|
US6969716B2
(en)
|
2003-02-07 |
2005-11-29 |
Merck Sharp & Dohme Ltd. |
5-phenyl[1,2,4]triazines as ligands for GABA-A α2/α3 receptors for treating anxiety or depression
|
|
AU2004212421B2
(en)
|
2003-02-07 |
2009-08-20 |
Vertex Pharmaceuticals Incorporated |
Heteroaryl substituted pyrolls useful as inhibitors of protein kinases
|
|
TWI292318B
(en)
|
2003-03-10 |
2008-01-11 |
Hoffmann La Roche |
Imidazol-4-yl-ethynyl-pyridine derivatives
|
|
KR20050122210A
(ko)
|
2003-03-17 |
2005-12-28 |
다케다 샌디에고, 인코포레이티드 |
히스톤 탈아세틸화 효소 억제제
|
|
JP2006521399A
(ja)
|
2003-03-28 |
2006-09-21 |
アカディア ファーマシューティカルズ，インコーポレーテッド |
疼痛管理用ムスカリンｍ１受容体アゴニスト
|
|
ATE365554T1
(de)
|
2003-04-04 |
2007-07-15 |
Dynogen Pharmaceuticals Inc |
Methode zur behandlung von erkrankungen der unteren harnwege
|
|
JP2006523710A
(ja)
|
2003-04-16 |
2006-10-19 |
メモリー・ファーマシューティカルズ・コーポレイション |
ホスホジエステラーゼ４インヒビター
|
|
US20040254152A1
(en)
|
2003-04-17 |
2004-12-16 |
Monje Michelle L. |
Prevention of deficits in neurogenesis with anti-inflammatory agents
|
|
GB0311859D0
(en)
|
2003-05-22 |
2003-06-25 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US7763588B2
(en)
|
2003-06-13 |
2010-07-27 |
The Salk Institute For Biological Studies |
Method for increasing cognitive function and neurogenesis
|
|
US7842835B2
(en)
|
2003-07-07 |
2010-11-30 |
Georgetown University |
Histone deacetylase inhibitors and methods of use thereof
|
|
KR100764330B1
(ko)
|
2003-07-25 |
2007-10-05 |
에프. 호프만-라 로슈 아게 |
급성 및/또는 만성 신경학적 장애의 치료를 위한ｍＧｌｕＲ2 길항제 및 ＡＣｈＥ 억제제의 조합물
|
|
US20050031538A1
(en)
|
2003-08-05 |
2005-02-10 |
Steindler Dennis A. |
Neural cell assay
|
|
TWI339206B
(en)
|
2003-09-04 |
2011-03-21 |
Vertex Pharma |
Compositions useful as inhibitors of protein kinases
|
|
EP1670455A4
(en)
|
2003-10-10 |
2008-10-15 |
Mars Inc |
TREATMENT OF DISEASES WITH ERBB2-KINASE OVEREXPRESSION
|
|
SI1541197T1
(sl)
*
|
2003-12-02 |
2009-08-31 |
Pharmaneuroboost N V |
Uporaba pipamperona in sndri, snri ali ssri za zdravljenje razpoloĺ˝enjskih ali tesnobnih motenj
|
|
WO2005065681A1
(en)
|
2003-12-19 |
2005-07-21 |
Takeda San Diego, Inc. |
N- hydroxy-3-(3-(1h-imidazol-2-yl)-phenyl)-acrylamide derivatives and related compounds as histone deacetylase (hdac) inhibitors for the treatment of cancer
|
|
WO2005066151A2
(en)
|
2003-12-19 |
2005-07-21 |
Takeda San Diego, Inc. |
Histone deacetylase inhibitors
|
|
CA2550735A1
(en)
|
2003-12-22 |
2005-07-14 |
Acadia Pharmaceuticals Inc. |
Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders
|
|
EP1718280A4
(en)
|
2004-01-30 |
2010-08-18 |
Mars Inc |
METHOD AND COMPOSITIONS FOR CANCER TREATMENT
|
|
TWI301760B
(en)
|
2004-02-27 |
2008-10-11 |
Merz Pharma Gmbh & Co Kgaa |
Tetrahydroquinolinones and their use as antagonists of metabotropic glutamate receptors
|
|
US20070015138A1
(en)
|
2005-07-08 |
2007-01-18 |
Braincells, Inc. |
Methods for identifying agents and conditions that modulate neurogenesis
|
|
CN101378752A
(zh)
*
|
2006-02-07 |
2009-03-04 |
田边三菱制药株式会社 |
4-酰氨基吡啶衍生物介导的神经发生
|