ES2189871T3 - Ciclohexil-dihidro-benzofuranos. - Google Patents

Ciclohexil-dihidro-benzofuranos.

Info

Publication number
ES2189871T3
ES2189871T3 ES96914207T ES96914207T ES2189871T3 ES 2189871 T3 ES2189871 T3 ES 2189871T3 ES 96914207 T ES96914207 T ES 96914207T ES 96914207 T ES96914207 T ES 96914207T ES 2189871 T3 ES2189871 T3 ES 2189871T3
Authority
ES
Spain
Prior art keywords
pct
date nov
sec
benzofuranos
ciclohexil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96914207T
Other languages
English (en)
Inventor
Hermann Amschler
Thomas Bar
Dieter Flockerzi
Beate Schmid
Ulrich Thibaut
Armin Hatzelmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Altana Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma AG filed Critical Altana Pharma AG
Application granted granted Critical
Publication of ES2189871T3 publication Critical patent/ES2189871T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7

Abstract

LOS COMPUESTOS DE FORMULA (I), DONDE R1, R2, R3 Y R4 Y R5 TIENEN LOS SIGNIFICADOS CITADOS EN LA MEMORIA DESCRIPTIVA, SON AGENTES NUEVOS Y POTENTES INHIBIDORES DE LA PDE.
ES96914207T 1995-05-18 1996-05-14 Ciclohexil-dihidro-benzofuranos. Expired - Lifetime ES2189871T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH147195 1995-05-18
DE19601911 1996-01-22

Publications (1)

Publication Number Publication Date
ES2189871T3 true ES2189871T3 (es) 2003-07-16

Family

ID=25687750

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96914207T Expired - Lifetime ES2189871T3 (es) 1995-05-18 1996-05-14 Ciclohexil-dihidro-benzofuranos.

Country Status (11)

Country Link
US (1) US6080782A (es)
EP (1) EP0828727B1 (es)
JP (1) JPH11505539A (es)
AT (1) ATE230404T1 (es)
AU (1) AU705723B2 (es)
CA (1) CA2221351A1 (es)
CY (1) CY2462B1 (es)
DE (1) DE59610031D1 (es)
DK (1) DK0828727T3 (es)
ES (1) ES2189871T3 (es)
WO (1) WO1996036626A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0934307B1 (en) 1996-06-19 2011-04-27 Aventis Pharma Limited Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase
PT941221E (pt) * 1996-11-20 2003-07-31 Altana Pharma Ag Dihidrobenzofuranos substituidos como inibidores de fosfodiesterase (pde)
US6376485B1 (en) * 1998-07-06 2002-04-23 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzoxazoles with PDE-inhibiting activity
GB9828340D0 (en) * 1998-12-22 1999-02-17 Novartis Ag Organic compounds
TR200909479T2 (tr) 1999-08-21 2012-02-21 Nycomed Gmbh Sinerjistik kombinasyon.
JP4588973B2 (ja) * 2000-09-06 2010-12-01 田辺三菱製薬株式会社 経口投与用製剤
EP1188438A1 (en) * 2000-09-15 2002-03-20 Warner-Lambert Company Pharmaceutical composition for preventing or treating a disease associated with an excess of Il-12 production
EP1199074A1 (en) * 2000-09-15 2002-04-24 Warner-Lambert Company Pharmaceutical composition for preventing or treating a disease associated with an excess of il-12 production
MXPA03007283A (es) * 2001-02-15 2003-12-04 Tanabe Seiyaku Co Tabletas que se desintegran rapidamente en la cavidad oral.
EP2258357A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
WO2007025177A2 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2382975A3 (en) 2006-05-09 2012-02-29 Braincells, Inc. Neurogenesis by modulating angiotensin
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
AU2007292848A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0633776B1 (en) * 1992-04-02 2001-05-09 Smithkline Beecham Corporation Compounds useful for treating allergic and inflammatory diseases
US5602173A (en) * 1992-04-02 1997-02-11 Smithkline Beecham Corporation Compounds useful for treating allergic and inflammatory diseases
MX9301942A (es) * 1992-04-02 1994-08-31 Smithkline Beecham Corp Derivados de ciclohexan-ilideno novedosos.
CZ14795A3 (en) * 1992-07-28 1996-07-17 Rhone Poulenc Rorer Ltd Benzene derivative containing phenyl group bound to aryl or heteroaryl fraction through an aliphatic or hetero atom containing group, process of its preparation and pharmaceutical composition containing thereof
DK0771794T3 (da) * 1995-05-19 2006-09-11 Kyowa Hakko Kogyo Kk Oxygenholdige heterocykliske forbindelser

Also Published As

Publication number Publication date
AU5764496A (en) 1996-11-29
US6080782A (en) 2000-06-27
WO1996036626A1 (de) 1996-11-21
AU705723B2 (en) 1999-05-27
DK0828727T3 (da) 2003-04-22
ATE230404T1 (de) 2003-01-15
CA2221351A1 (en) 1996-11-21
EP0828727A1 (de) 1998-03-18
DE59610031D1 (de) 2003-02-06
JPH11505539A (ja) 1999-05-21
EP0828727B1 (de) 2003-01-02
CY2462B1 (en) 2005-06-03

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