LT3113797T - Antikūnai, panaudojimai ir būdai - Google Patents

Antikūnai, panaudojimai ir būdai

Info

Publication number
LT3113797T
LT3113797T LTEPPCT/GB2015/050614T LT15050614T LT3113797T LT 3113797 T LT3113797 T LT 3113797T LT 15050614 T LT15050614 T LT 15050614T LT 3113797 T LT3113797 T LT 3113797T
Authority
LT
Lithuania
Prior art keywords
antibodies
methods
Prior art date
Application number
LTEPPCT/GB2015/050614T
Other languages
English (en)
Lithuanian (lt)
Inventor
Jamie Campbell
Steve Holmes
Ian Kirby
Miha Kosmac
Original Assignee
Kymab Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kymab Limited filed Critical Kymab Limited
Publication of LT3113797T publication Critical patent/LT3113797T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
LTEPPCT/GB2015/050614T 2014-03-04 2015-03-03 Antikūnai, panaudojimai ir būdai LT3113797T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB201403775A GB201403775D0 (en) 2014-03-04 2014-03-04 Antibodies, uses & methods
PCT/GB2015/050614 WO2015132580A1 (en) 2014-03-04 2015-03-03 Antibodies, uses & methods

Publications (1)

Publication Number Publication Date
LT3113797T true LT3113797T (lt) 2022-09-12

Family

ID=50490750

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEPPCT/GB2015/050614T LT3113797T (lt) 2014-03-04 2015-03-03 Antikūnai, panaudojimai ir būdai

Country Status (21)

Country Link
US (9) US10669342B2 (enExample)
EP (2) EP3113797B1 (enExample)
JP (5) JP6795398B2 (enExample)
CN (2) CN112048020B (enExample)
AU (4) AU2015225926B2 (enExample)
CA (1) CA2941066C (enExample)
DE (1) DE112015001085T5 (enExample)
DK (1) DK3113797T3 (enExample)
ES (1) ES2922734T3 (enExample)
GB (1) GB201403775D0 (enExample)
HR (1) HRP20220891T1 (enExample)
HU (1) HUE059338T2 (enExample)
IL (3) IL247582B2 (enExample)
LT (1) LT3113797T (enExample)
NZ (1) NZ723858A (enExample)
PL (1) PL3113797T3 (enExample)
PT (1) PT3113797T (enExample)
RS (1) RS63408B1 (enExample)
SG (1) SG11201607030PA (enExample)
SI (1) SI3113797T1 (enExample)
WO (1) WO2015132580A1 (enExample)

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GB201403775D0 (en) * 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
PL3265123T3 (pl) * 2015-03-03 2023-03-13 Kymab Limited Przeciwciała, zastosowania i sposoby
US9139653B1 (en) 2015-04-30 2015-09-22 Kymab Limited Anti-human OX40L antibodies and methods of treatment
US9512229B2 (en) * 2015-03-03 2016-12-06 Kymab Limited Synergistic combinations of OX40L antibodies for the treatment of GVHD
US9897378B2 (en) 2015-10-08 2018-02-20 Nyc Designed Inspirations Llc Cosmetic makeup sponge/blender container
US9567399B1 (en) 2016-06-20 2017-02-14 Kymab Limited Antibodies and immunocytokines
KR102379464B1 (ko) 2016-06-20 2022-03-29 키맵 리미티드 항-pd-l1 항체
RU2764548C2 (ru) * 2016-08-09 2022-01-18 Кимаб Лимитед Анти-icos антитела
CN109890299A (zh) * 2016-08-18 2019-06-14 普罗根尼蒂公司 采样系统及相关材料和方法
WO2018083248A1 (en) 2016-11-03 2018-05-11 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses & methods
GB201709808D0 (en) 2017-06-20 2017-08-02 Kymab Ltd Antibodies
GB201721338D0 (en) 2017-12-19 2018-01-31 Kymab Ltd Anti-icos Antibodies
WO2019122882A1 (en) 2017-12-19 2019-06-27 Kymab Limited Bispecific antibody for icos and pd-l1
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CN111529753A (zh) * 2020-04-28 2020-08-14 宁夏医科大学总医院 氧化苦参碱-胎盘间充质干细胞水凝胶、制备方法及应用
EP4530358A3 (en) * 2020-09-15 2025-06-18 10x Genomics, Inc. Methods of releasing an extended capture probe from a substrate and uses of the same
AU2020480890B2 (en) * 2020-12-09 2026-07-02 Hk Inno.N Corporation ANTI-OX40L ANTIBODY, ANTI-OX40L/ANTI-TNFα BISPECIFIC ANTIBODY, AND USES THEREOF
CN112852743B (zh) * 2021-01-25 2021-11-02 江苏荃信生物医药有限公司 用于生产乌司奴单抗的生物类似药的细胞株及生产方法
EP4373848A2 (en) 2021-07-22 2024-05-29 University of Dundee Therapeutic muteins
MX2024001877A (es) * 2021-08-10 2024-02-28 Kymab Ltd Tratamiento de dermatitis atopica.
JP2026514048A (ja) 2023-04-14 2026-05-01 カイマブ・リミテッド 抗ｏｘ４０ｌ抗体を含有する医薬製剤
JP2026514143A (ja) * 2023-04-28 2026-05-01 アポジー セラピューティクス， インコーポレイテッド Ｏｘ４０ｌに結合する抗体及びその使用方法
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SI3113797T1 (sl) 2022-10-28
IL304772A (en) 2023-09-01
JP6795398B2 (ja) 2020-12-02
US20170044250A1 (en) 2017-02-16
JP7375062B2 (ja) 2023-11-07
JP2020202866A (ja) 2020-12-24
JP2017513813A (ja) 2017-06-01
SG11201607030PA (en) 2016-09-29
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AU2020294246B2 (en) 2024-05-23
US20250263492A1 (en) 2025-08-21
JP2026012798A (ja) 2026-01-27
NZ761537A (en) 2024-03-22
PT3113797T (pt) 2022-07-11
US20170327587A1 (en) 2017-11-16
US20190276547A1 (en) 2019-09-12
CA2941066A1 (en) 2015-09-11
PL3113797T3 (pl) 2022-09-12
US11753479B2 (en) 2023-09-12
EP3113797A1 (en) 2017-01-11
AU2015225926B2 (en) 2020-10-15
CN106459196A (zh) 2017-02-22
US10669342B2 (en) 2020-06-02
IL247582B2 (en) 2024-01-01
DK3113797T3 (da) 2022-07-25
AU2020294247B2 (en) 2024-08-01
US20160368997A1 (en) 2016-12-22
WO2015132580A1 (en) 2015-09-11
AU2024227793A1 (en) 2024-11-21
CN112048020B (zh) 2025-07-08
IL247582A0 (en) 2016-11-30
IL304772B2 (en) 2025-10-01
IL304772B1 (en) 2025-06-01
US11396550B2 (en) 2022-07-26
US11773175B2 (en) 2023-10-03
US20170002083A1 (en) 2017-01-05
JP2022078042A (ja) 2022-05-24
US20210087287A1 (en) 2021-03-25
IL247582B1 (en) 2023-09-01
AU2020294246A1 (en) 2021-01-28
US20210395378A1 (en) 2021-12-23
DE112015001085T5 (de) 2016-12-08
US9587030B2 (en) 2017-03-07
AU2015225926A1 (en) 2016-09-22
RS63408B1 (sr) 2022-08-31
CN106459196B (zh) 2020-09-22
EP3590539A1 (en) 2020-01-08
HUE059338T2 (hu) 2022-11-28

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