HUE059338T2 - Ellenanyagok, alkalmazások és eljárások - Google Patents

Ellenanyagok, alkalmazások és eljárások

Info

Publication number
HUE059338T2
HUE059338T2 HUE15714253A HUE15714253A HUE059338T2 HU E059338 T2 HUE059338 T2 HU E059338T2 HU E15714253 A HUE15714253 A HU E15714253A HU E15714253 A HUE15714253 A HU E15714253A HU E059338 T2 HUE059338 T2 HU E059338T2
Authority
HU
Hungary
Prior art keywords
antibodies
procedures
applications
Prior art date
Application number
HUE15714253A
Other languages
English (en)
Hungarian (hu)
Inventor
Jamie Campbell
Steve Holmes
Ian Kirby
Miha Kosmac
Original Assignee
Kymab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kymab Ltd filed Critical Kymab Ltd
Publication of HUE059338T2 publication Critical patent/HUE059338T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HUE15714253A 2014-03-04 2015-03-03 Ellenanyagok, alkalmazások és eljárások HUE059338T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB201403775A GB201403775D0 (en) 2014-03-04 2014-03-04 Antibodies, uses & methods

Publications (1)

Publication Number Publication Date
HUE059338T2 true HUE059338T2 (hu) 2022-11-28

Family

ID=50490750

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE15714253A HUE059338T2 (hu) 2014-03-04 2015-03-03 Ellenanyagok, alkalmazások és eljárások

Country Status (21)

Country Link
US (9) US10669342B2 (enExample)
EP (2) EP3590539A1 (enExample)
JP (4) JP6795398B2 (enExample)
CN (2) CN112048020B (enExample)
AU (4) AU2015225926B2 (enExample)
CA (1) CA2941066C (enExample)
DE (1) DE112015001085T5 (enExample)
DK (1) DK3113797T3 (enExample)
ES (1) ES2922734T3 (enExample)
GB (1) GB201403775D0 (enExample)
HR (1) HRP20220891T1 (enExample)
HU (1) HUE059338T2 (enExample)
IL (3) IL247582B2 (enExample)
LT (1) LT3113797T (enExample)
NZ (1) NZ723858A (enExample)
PL (1) PL3113797T3 (enExample)
PT (1) PT3113797T (enExample)
RS (1) RS63408B1 (enExample)
SG (1) SG11201607030PA (enExample)
SI (1) SI3113797T1 (enExample)
WO (1) WO2015132580A1 (enExample)

Families Citing this family (26)

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GB201403775D0 (en) * 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
DE112016001013T5 (de) * 2015-03-03 2017-12-21 Kymab Limited Antikörper, verwendungen und verfahren
US9512229B2 (en) 2015-03-03 2016-12-06 Kymab Limited Synergistic combinations of OX40L antibodies for the treatment of GVHD
US9897378B2 (en) 2015-10-08 2018-02-20 Nyc Designed Inspirations Llc Cosmetic makeup sponge/blender container
US9567399B1 (en) 2016-06-20 2017-02-14 Kymab Limited Antibodies and immunocytokines
TW201803905A (zh) 2016-06-20 2018-02-01 克馬伯有限公司 用於免疫腫瘤學之多重專一性抗體
KR102604433B1 (ko) * 2016-08-09 2023-11-24 키맵 리미티드 항-icos 항체
WO2018035396A1 (en) * 2016-08-18 2018-02-22 Mitchell Lawrence Jones Sampling systems and related materials and methods
EP3534947A1 (en) 2016-11-03 2019-09-11 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses & methods
GB201709808D0 (en) 2017-06-20 2017-08-02 Kymab Ltd Antibodies
EP3728314A1 (en) 2017-12-19 2020-10-28 Kymab Limited Bispecific antibody for icos and pd-l1
GB201721338D0 (en) 2017-12-19 2018-01-31 Kymab Ltd Anti-icos Antibodies
EP3762400A4 (en) * 2018-03-08 2022-03-16 Magenta Therapeutics, Inc. ANTI-CD252 ANTIBODIES, CONJUGATES AND METHODS OF USE
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WO2019178852A1 (zh) * 2018-03-23 2019-09-26 苏州丁孚靶点生物技术有限公司 Ox40抗原多肽及其用途
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CN111529753A (zh) * 2020-04-28 2020-08-14 宁夏医科大学总医院 氧化苦参碱-胎盘间充质干细胞水凝胶、制备方法及应用
EP4530358A3 (en) * 2020-09-15 2025-06-18 10x Genomics, Inc. Methods of releasing an extended capture probe from a substrate and uses of the same
CN117440967A (zh) * 2020-12-09 2024-01-23 怡诺安有限公司 抗OX40L抗体、抗OX40L/抗TNFα双特异性抗体及其用途
CN112852743B (zh) * 2021-01-25 2021-11-02 江苏荃信生物医药有限公司 用于生产乌司奴单抗的生物类似药的细胞株及生产方法
EP4373848A2 (en) 2021-07-22 2024-05-29 University of Dundee Therapeutic muteins
JP2024530954A (ja) * 2021-08-10 2024-08-27 カイマブ・リミテッド アトピー性皮膚炎の処置
WO2024213774A1 (en) 2023-04-14 2024-10-17 Kymab Limited Pharmaceutical formulations containing anti-ox40l antibodies
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WO2025233445A1 (en) 2024-05-08 2025-11-13 Kymab Limited Treatment of head and neck atopic dermatitis

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US20250263492A1 (en) 2025-08-21
ES2922734T3 (es) 2022-09-19
CN112048020B (zh) 2025-07-08
NZ761537A (en) 2024-03-22
US20210395378A1 (en) 2021-12-23
IL247582B1 (en) 2023-09-01
CN112048020A (zh) 2020-12-08
US10654935B2 (en) 2020-05-19
JP2022078042A (ja) 2022-05-24
US20170327587A1 (en) 2017-11-16
US20170044250A1 (en) 2017-02-16
AU2020294247B2 (en) 2024-08-01
US11753479B2 (en) 2023-09-12
CN106459196B (zh) 2020-09-22
LT3113797T (lt) 2022-09-12
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RS63408B1 (sr) 2022-08-31
US20210087287A1 (en) 2021-03-25

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