AU2015225926B2 - Antibodies, uses & methods - Google Patents

Antibodies, uses & methods Download PDF

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Publication number
AU2015225926B2
AU2015225926B2 AU2015225926A AU2015225926A AU2015225926B2 AU 2015225926 B2 AU2015225926 B2 AU 2015225926B2 AU 2015225926 A AU2015225926 A AU 2015225926A AU 2015225926 A AU2015225926 A AU 2015225926A AU 2015225926 B2 AU2015225926 B2 AU 2015225926B2
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AU
Australia
Prior art keywords
antibody
seq
hox40l
antibodies
human
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AU2015225926A
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English (en)
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AU2015225926A1 (en
Inventor
Jamie Campbell
Steve Holmes
Ian Kirby
Miha Kosmac
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Kymab Ltd
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Kymab Ltd
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Publication of AU2015225926A1 publication Critical patent/AU2015225926A1/en
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Publication of AU2015225926B2 publication Critical patent/AU2015225926B2/en
Priority to AU2020294246A priority Critical patent/AU2020294246B2/en
Priority to AU2020294247A priority patent/AU2020294247B2/en
Priority to AU2024227793A priority patent/AU2024227793A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2015225926A 2014-03-04 2015-03-03 Antibodies, uses & methods Active AU2015225926B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2020294246A AU2020294246B2 (en) 2014-03-04 2020-12-23 Antibodies, uses & methods
AU2020294247A AU2020294247B2 (en) 2014-03-04 2020-12-23 Antibodies, uses & methods
AU2024227793A AU2024227793A1 (en) 2014-03-04 2024-10-31 Antibodies, uses & methods

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB201403775A GB201403775D0 (en) 2014-03-04 2014-03-04 Antibodies, uses & methods
GB1403775.8 2014-03-04
PCT/GB2015/050614 WO2015132580A1 (en) 2014-03-04 2015-03-03 Antibodies, uses & methods

Related Child Applications (2)

Application Number Title Priority Date Filing Date
AU2020294247A Division AU2020294247B2 (en) 2014-03-04 2020-12-23 Antibodies, uses & methods
AU2020294246A Division AU2020294246B2 (en) 2014-03-04 2020-12-23 Antibodies, uses & methods

Publications (2)

Publication Number Publication Date
AU2015225926A1 AU2015225926A1 (en) 2016-09-22
AU2015225926B2 true AU2015225926B2 (en) 2020-10-15

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AU2015225926A Active AU2015225926B2 (en) 2014-03-04 2015-03-03 Antibodies, uses & methods
AU2020294247A Active AU2020294247B2 (en) 2014-03-04 2020-12-23 Antibodies, uses & methods
AU2020294246A Active AU2020294246B2 (en) 2014-03-04 2020-12-23 Antibodies, uses & methods
AU2024227793A Pending AU2024227793A1 (en) 2014-03-04 2024-10-31 Antibodies, uses & methods

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AU2020294247A Active AU2020294247B2 (en) 2014-03-04 2020-12-23 Antibodies, uses & methods
AU2020294246A Active AU2020294246B2 (en) 2014-03-04 2020-12-23 Antibodies, uses & methods
AU2024227793A Pending AU2024227793A1 (en) 2014-03-04 2024-10-31 Antibodies, uses & methods

Country Status (21)

Country Link
US (9) US10669342B2 (enExample)
EP (2) EP3113797B1 (enExample)
JP (5) JP6795398B2 (enExample)
CN (2) CN112048020B (enExample)
AU (4) AU2015225926B2 (enExample)
CA (1) CA2941066C (enExample)
DE (1) DE112015001085T5 (enExample)
DK (1) DK3113797T3 (enExample)
ES (1) ES2922734T3 (enExample)
GB (1) GB201403775D0 (enExample)
HR (1) HRP20220891T1 (enExample)
HU (1) HUE059338T2 (enExample)
IL (3) IL304772B2 (enExample)
LT (1) LT3113797T (enExample)
NZ (1) NZ723858A (enExample)
PL (1) PL3113797T3 (enExample)
PT (1) PT3113797T (enExample)
RS (1) RS63408B1 (enExample)
SG (1) SG11201607030PA (enExample)
SI (1) SI3113797T1 (enExample)
WO (1) WO2015132580A1 (enExample)

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GB201403775D0 (en) * 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
KR102740384B1 (ko) * 2015-03-03 2024-12-06 키맵 리미티드 항체, 용도 및 방법
US9139653B1 (en) 2015-04-30 2015-09-22 Kymab Limited Anti-human OX40L antibodies and methods of treatment
US9512229B2 (en) * 2015-03-03 2016-12-06 Kymab Limited Synergistic combinations of OX40L antibodies for the treatment of GVHD
US9897378B2 (en) 2015-10-08 2018-02-20 Nyc Designed Inspirations Llc Cosmetic makeup sponge/blender container
US9567399B1 (en) 2016-06-20 2017-02-14 Kymab Limited Antibodies and immunocytokines
JP7461741B2 (ja) 2016-06-20 2024-04-04 カイマブ・リミテッド 抗ｐｄ－ｌ１およびｉｌ－２サイトカイン
CA3032897A1 (en) 2016-08-09 2018-02-15 Kymab Limited Anti-icos antibodies
CA3034263A1 (en) * 2016-08-18 2018-02-22 Mitchell Lawrence Jones Sampling systems and related materials and methods
US11779604B2 (en) 2016-11-03 2023-10-10 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses and methods
GB201709808D0 (en) 2017-06-20 2017-08-02 Kymab Ltd Antibodies
GB201721338D0 (en) 2017-12-19 2018-01-31 Kymab Ltd Anti-icos Antibodies
EP3728314A1 (en) 2017-12-19 2020-10-28 Kymab Limited Bispecific antibody for icos and pd-l1
JP2021517133A (ja) * 2018-03-08 2021-07-15 マジェンタ セラピューティクス インコーポレイテッドＭａｇｅｎｔａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 抗ｃｄ２５２抗体、コンジュゲート、および使用方法
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WO2019178852A1 (zh) * 2018-03-23 2019-09-26 苏州丁孚靶点生物技术有限公司 Ox40抗原多肽及其用途
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MX2022006881A (es) * 2019-12-06 2022-07-11 Ablynx Nv Polipeptidos que comprenden dominios variables unicos de inmunoglobulina dirigidos a tnf alfa y ox40l.
CN111529753A (zh) * 2020-04-28 2020-08-14 宁夏医科大学总医院 氧化苦参碱-胎盘间充质干细胞水凝胶、制备方法及应用
CN116547388A (zh) * 2020-09-15 2023-08-04 10X基因组学有限公司 从基材中释放延伸的捕获探针的方法及其应用
CN117440967A (zh) * 2020-12-09 2024-01-23 怡诺安有限公司 抗OX40L抗体、抗OX40L/抗TNFα双特异性抗体及其用途
CN112852743B (zh) * 2021-01-25 2021-11-02 江苏荃信生物医药有限公司 用于生产乌司奴单抗的生物类似药的细胞株及生产方法
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EP4695292A1 (en) 2023-04-14 2026-02-18 Kymab Limited Pharmaceutical formulations containing anti-ox40l antibodies
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