KR20220163505A - 바이러스 동역학에 미치는 영향 최소화를 위한 치료용 아데노바이러스의 외인성 유전자 발현 - Google Patents
바이러스 동역학에 미치는 영향 최소화를 위한 치료용 아데노바이러스의 외인성 유전자 발현 Download PDFInfo
- Publication number
- KR20220163505A KR20220163505A KR1020227040992A KR20227040992A KR20220163505A KR 20220163505 A KR20220163505 A KR 20220163505A KR 1020227040992 A KR1020227040992 A KR 1020227040992A KR 20227040992 A KR20227040992 A KR 20227040992A KR 20220163505 A KR20220163505 A KR 20220163505A
- Authority
- KR
- South Korea
- Prior art keywords
- orf
- recombinant adenovirus
- peptide
- tumor
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10041—Use of virus, viral particle or viral elements as a vector
- C12N2710/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10051—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662298653P | 2016-02-23 | 2016-02-23 | |
| US62/298,653 | 2016-02-23 | ||
| PCT/US2017/019086 WO2017147269A1 (en) | 2016-02-23 | 2017-02-23 | Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics |
| KR1020217016040A KR102471633B1 (ko) | 2016-02-23 | 2017-02-23 | 바이러스 동역학에 미치는 영향 최소화를 위한 치료용 아데노바이러스의 외인성 유전자 발현 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020217016040A Division KR102471633B1 (ko) | 2016-02-23 | 2017-02-23 | 바이러스 동역학에 미치는 영향 최소화를 위한 치료용 아데노바이러스의 외인성 유전자 발현 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20220163505A true KR20220163505A (ko) | 2022-12-09 |
Family
ID=58358815
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020227040992A Ceased KR20220163505A (ko) | 2016-02-23 | 2017-02-23 | 바이러스 동역학에 미치는 영향 최소화를 위한 치료용 아데노바이러스의 외인성 유전자 발현 |
| KR1020187026673A Abandoned KR20180112024A (ko) | 2016-02-23 | 2017-02-23 | 바이러스 동역학에 미치는 영향 최소화를 위한 치료용 아데노바이러스의 외인성 유전자 발현 |
| KR1020217016040A Active KR102471633B1 (ko) | 2016-02-23 | 2017-02-23 | 바이러스 동역학에 미치는 영향 최소화를 위한 치료용 아데노바이러스의 외인성 유전자 발현 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020187026673A Abandoned KR20180112024A (ko) | 2016-02-23 | 2017-02-23 | 바이러스 동역학에 미치는 영향 최소화를 위한 치료용 아데노바이러스의 외인성 유전자 발현 |
| KR1020217016040A Active KR102471633B1 (ko) | 2016-02-23 | 2017-02-23 | 바이러스 동역학에 미치는 영향 최소화를 위한 치료용 아데노바이러스의 외인성 유전자 발현 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US10738325B2 (enExample) |
| EP (2) | EP4155411A1 (enExample) |
| JP (3) | JP7015551B2 (enExample) |
| KR (3) | KR20220163505A (enExample) |
| CN (2) | CN117384961A (enExample) |
| AU (2) | AU2017223589B2 (enExample) |
| CA (1) | CA3013639A1 (enExample) |
| ES (1) | ES2933174T3 (enExample) |
| WO (1) | WO2017147269A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6576326B2 (ja) | 2013-03-14 | 2019-09-18 | ソーク インスティテュート フォー バイオロジカル スタディーズ | 腫瘍溶解性アデノウイルス組成物 |
| AU2016333996B2 (en) | 2015-10-05 | 2020-05-28 | Salk Institute For Biological Studies | Synthetic adenoviruses with tropism to damaged tissue for use in promoting wound repair and tissue regeneration |
| JP7054527B2 (ja) | 2016-02-23 | 2022-04-14 | ソーク インスティテュート フォー バイオロジカル スタディーズ | アデノウイルスの複製動態を測定するための高スループットアッセイ |
| KR20220163505A (ko) * | 2016-02-23 | 2022-12-09 | 솔크 인스티튜트 포 바이올로지칼 스터디즈 | 바이러스 동역학에 미치는 영향 최소화를 위한 치료용 아데노바이러스의 외인성 유전자 발현 |
| JP2019536468A (ja) | 2016-12-12 | 2019-12-19 | ソーク インスティテュート フォー バイオロジカル スタディーズ | 腫瘍を標的にする合成アデノウイルスおよびその使用 |
| AU2019251356B2 (en) * | 2018-04-09 | 2025-06-12 | Salk Institute For Biological Studies | Oncolytic adenovirus compositions with enhanced replication properties |
| CN109758467B (zh) * | 2019-03-08 | 2020-12-25 | 中国农业科学院兰州兽医研究所 | 一种吉西他滨在制备预防口蹄疫病毒感染的药物中的应用 |
| WO2020252093A1 (en) * | 2019-06-10 | 2020-12-17 | Infectious Disease Research Institute | Methods and compositions of astrovirus replicons |
| EP4133091A4 (en) * | 2020-04-10 | 2024-07-03 | Washington State University | UNIVERSAL GENE EXPRESSION SYSTEM FOR THE EXPRESSION OF GENES IN OILY YEASTS |
| EP4176066A4 (en) * | 2020-07-06 | 2024-10-30 | Salk Institute for Biological Studies | Recombinant adenovirus genome having a synthetic transcriptional unit and two step transcriptional regulation and amplification |
| CN112592388A (zh) * | 2020-12-14 | 2021-04-02 | 河南普诺易生物制品研究院有限公司 | 一种2a肽、双顺反子表达载体、重组蛋白表达系统及应用 |
| EP4297769A2 (en) * | 2021-02-19 | 2024-01-03 | Preet M. Chaudhary | Single-chain and multi-chain synthetic antigen receptors for diverse immune cells |
| JP2024540002A (ja) | 2021-10-25 | 2024-10-31 | ジェンビーボ・インコーポレイテッド | 治療剤送達のための組成物および方法 |
Family Cites Families (334)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5670488A (en) | 1992-12-03 | 1997-09-23 | Genzyme Corporation | Adenovirus vector for gene therapy |
| US6410010B1 (en) | 1992-10-13 | 2002-06-25 | Board Of Regents, The University Of Texas System | Recombinant P53 adenovirus compositions |
| US5747469A (en) | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| FR2688514A1 (fr) | 1992-03-16 | 1993-09-17 | Centre Nat Rech Scient | Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant. |
| US5801029A (en) | 1993-02-16 | 1998-09-01 | Onyx Pharmaceuticals, Inc. | Cytopathic viruses for therapy and prophylaxis of neoplasia |
| ES2157109T3 (es) | 1993-02-16 | 2001-08-01 | Onyx Pharma Inc | Virus citopaticos para el tratamiento y la profilasis de la neoplasia. |
| US7045347B2 (en) | 1993-06-24 | 2006-05-16 | Advec, Inc. | Helper dependent adenovirus vectors based on integrase family site-specific recombinases |
| US5543328A (en) | 1993-08-13 | 1996-08-06 | Genetic Therapy, Inc. | Adenoviruses having modified fiber proteins |
| US20010006629A1 (en) | 1993-10-25 | 2001-07-05 | Richard J. Gregory | Recombinant adenoviral vector and methods of use |
| US7252989B1 (en) | 1994-04-04 | 2007-08-07 | Board Of Regents, The University Of Texas System | Adenovirus supervector system |
| US5846782A (en) | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
| US5559099A (en) | 1994-09-08 | 1996-09-24 | Genvec, Inc. | Penton base protein and methods of using same |
| US5962311A (en) | 1994-09-08 | 1999-10-05 | Genvec, Inc. | Short-shafted adenoviral fiber and its use |
| US6465253B1 (en) | 1994-09-08 | 2002-10-15 | Genvec, Inc. | Vectors and methods for gene transfer to cells |
| US5965541A (en) | 1995-11-28 | 1999-10-12 | Genvec, Inc. | Vectors and methods for gene transfer to cells |
| FR2726285B1 (fr) | 1994-10-28 | 1996-11-29 | Centre Nat Rech Scient | Adenovirus depourvus de particules contaminantes viables, preparation et utilisation |
| AU709498B2 (en) | 1994-12-12 | 1999-09-02 | Genetic Therapy, Inc. | Improved adenoviral vectors and producer cells |
| US6127525A (en) | 1995-02-21 | 2000-10-03 | Cornell Research Foundation, Inc. | Chimeric adenoviral coat protein and methods of using same |
| US5770442A (en) | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
| US20030026789A1 (en) | 1995-05-03 | 2003-02-06 | Richard J. Gregory | Gene therapy using replication competent targeted adenoviral vectors |
| US6506379B1 (en) | 1995-06-07 | 2003-01-14 | Ariad Gene Therapeutics, Inc. | Intramuscular delivery of recombinant AAV |
| AUPN477695A0 (en) | 1995-08-14 | 1995-09-07 | Commonwealth Scientific And Industrial Research Organisation | Gene therapy |
| US5945335A (en) | 1995-11-09 | 1999-08-31 | Avigen, Inc. | Adenovirus helper-free system for producing recombinant AAV virions lacking oncogenic sequences |
| JP2000500020A (ja) | 1995-11-13 | 2000-01-11 | コミサリア・ア・レネルジー・アトミーク | 正十二面体様アデノウイルス・タンパク質複合体、それを含む組成物、及びその使用方法 |
| IL124654A0 (en) | 1995-11-28 | 1998-12-06 | Genvec Inc | Vectors and method for gene transfer to cells |
| US6133243A (en) | 1996-02-22 | 2000-10-17 | Onyx Pharmaceuticals, Inc. | Liposomal-viral DNA complexes for treating disease |
| FR2746110B1 (fr) | 1996-03-14 | 1998-04-17 | Methode de traitement par therapie genique des tumeurs humaines et virus recombinants correspondants | |
| US6506602B1 (en) | 1996-03-25 | 2003-01-14 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| JP2000514290A (ja) | 1996-07-01 | 2000-10-31 | ローヌ―プーラン・ロレ・エス・アー | 組換えアデノウイルスの製造方法 |
| US7232899B2 (en) | 1996-09-25 | 2007-06-19 | The Scripps Research Institute | Adenovirus vectors, packaging cell lines, compositions, and methods for preparation and use |
| US5922315A (en) | 1997-01-24 | 1999-07-13 | Genetic Therapy, Inc. | Adenoviruses having altered hexon proteins |
| US6403370B1 (en) | 1997-02-10 | 2002-06-11 | Genstar Therapeutics Corporation | Oncolytic/immunogenic complementary-adenoviral vector system |
| US20050287120A1 (en) | 1997-03-21 | 2005-12-29 | Fisher Paul B | Cancer - targeted viral vectors |
| FR2761689B1 (fr) | 1997-04-02 | 1999-06-25 | Transgene Sa | Fibre adenovirale modifiee et adenovirus cibles |
| CA2291323A1 (en) | 1997-05-28 | 1998-12-03 | Genvec, Inc. | Alternatively targeted adenovirus |
| US6200799B1 (en) | 1997-06-03 | 2001-03-13 | University Of Lausanne | Somatic gene therapy to suppress secondary cataract formation following eye surgery |
| EP0996735B1 (en) | 1997-06-09 | 2003-12-10 | Genvec, Inc. | Chimeric vectors comprising a phage packaging site and a portion derived from the genome of a eukaryotic virus |
| CN1281512A (zh) | 1997-12-12 | 2001-01-24 | 昂尼克斯药物公司 | p53+肿瘤细胞的选择性杀伤和诊断 |
| IL137681A0 (en) | 1998-02-06 | 2001-10-31 | Uab Research Foundation | Adenovirus vector containing a heterologous peptide epitope in the hi loop of the fiber knob |
| US6984635B1 (en) | 1998-02-13 | 2006-01-10 | Board Of Trustees Of The Leland Stanford Jr. University | Dimerizing agents, their production and use |
| AU751542B2 (en) | 1998-02-17 | 2002-08-22 | Uab Research Foundation, The | Modified adenovirus containing a fiber replacement protein |
| US20050095231A1 (en) | 1998-02-17 | 2005-05-05 | Curiel David T. | Modified adenovirus containing a fiber replacement protein |
| WO1999044423A1 (en) | 1998-03-03 | 1999-09-10 | The Uab Research Foundation | Amplification of gene transfer and gene therapy by controlled replication |
| AU3358999A (en) | 1998-03-20 | 1999-10-11 | Genzyme Corporation | Chimeric adenoviral vectors for targeted gene delivery |
| US7829329B2 (en) | 1998-04-24 | 2010-11-09 | Onyx Pharmaceuticals, Inc. | Adenoviral vectors for treating disease |
| US6670188B1 (en) | 1998-04-24 | 2003-12-30 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
| DK1199368T3 (da) | 1998-07-07 | 2004-04-13 | Transgene Sa | Anvendelse af adenovirus-E4-læserammer til forbedring af ekspression af et gen af interesse |
| US20030017138A1 (en) | 1998-07-08 | 2003-01-23 | Menzo Havenga | Chimeric adenoviruses |
| CN1257286C (zh) | 1998-08-27 | 2006-05-24 | 森泰莱昂公司 | 用于递送异源基因的定向腺病毒载体 |
| US6900049B2 (en) | 1998-09-10 | 2005-05-31 | Cell Genesys, Inc. | Adenovirus vectors containing cell status-specific response elements and methods of use thereof |
| AU767975B2 (en) | 1998-09-11 | 2003-11-27 | Genvec, Inc. | Alternatively targeted adenovirus |
| US6841540B1 (en) | 1998-09-29 | 2005-01-11 | The Uab Research Foundation | Immunomodulation by genetic modification of dendritic cells and B cells |
| SK4412001A3 (en) | 1998-10-15 | 2001-12-03 | Canji Inc | Selectively replicating viral vectors |
| US20020037274A1 (en) | 1998-10-26 | 2002-03-28 | Angelica Williams | Single agent method for killing tumor and tumor associated endothelial cells using adenoviral mutants |
| US6929946B1 (en) | 1998-11-20 | 2005-08-16 | Crucell Holland B.V. | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
| JP2002534130A (ja) | 1999-01-14 | 2002-10-15 | ノバルティス アクチエンゲゼルシャフト | アデノウイルスベクター、パッケージ細胞系、組成物および製法および使用法 |
| US6395875B1 (en) | 1999-01-25 | 2002-05-28 | Brookhaven Science Associates Llc | Recombinant soluble adenovirus receptor |
| US7157266B2 (en) | 1999-01-25 | 2007-01-02 | Brookhaven Science Associates Llc | Structure of adenovirus bound to cellular receptor car |
| WO2000052186A1 (en) | 1999-03-04 | 2000-09-08 | Introgene B.V. | Means and methods for fibroblast-like or macrophage-like cell transduction |
| US6869936B1 (en) | 1999-03-04 | 2005-03-22 | Crucell Holland B.V. | Means and methods for fibroblast-like or macrophage-like cell transduction |
| AU767904B2 (en) | 1999-05-12 | 2003-11-27 | Uab Research Foundation, The | Infectivity-enhanced conditionally-replicative adenovirus and uses thereof |
| US20040175362A1 (en) | 1999-05-12 | 2004-09-09 | Curiel David T. | Infectivity-enhanced conditionally-replicative adenovirus and uses thereof |
| PT1816205E (pt) | 1999-05-17 | 2011-11-15 | Crucell Holland Bv | Adenovírus recombinante baseado no serótipo 48 (ad48) |
| US20050232900A1 (en) | 1999-05-18 | 2005-10-20 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
| US6913922B1 (en) | 1999-05-18 | 2005-07-05 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
| EP1593742A3 (en) | 1999-06-01 | 2006-02-01 | The University of Washington | Recombinant adenoviral vectors expressing chimeric fiber proteins for cell specific infection |
| US7094398B1 (en) | 1999-06-01 | 2006-08-22 | University Of Washington | Recombinant adenoviral vectors expressing chimeric fiber proteins for cell specific infection and genome integration |
| ATE291633T1 (de) | 1999-06-01 | 2005-04-15 | Univ Washington | Rekombinante adenovirale vektoren, die chimäre fiberproteine exprimieren, für die zellspezifische infektion und genomische integration |
| FR2794771B1 (fr) | 1999-06-11 | 2001-08-10 | Aventis Pharma Sa | Adenovirus recombinants codant pour le transporteur specifique de l'iode (nis) |
| DE19929569A1 (de) | 1999-06-21 | 2000-12-28 | Holm Per Sonne | Mittel zur Behandlung maligner Erkrankungen unter Verwendung des Proteins YB-1 |
| CN1359391A (zh) | 1999-07-06 | 2002-07-17 | 哥德-A-基因股份公司 | 重组腺病毒 |
| US7589069B1 (en) | 1999-07-12 | 2009-09-15 | Saint Louis University | Replication-competent anti-cancer vectors |
| CA2348158A1 (fr) | 1999-08-27 | 2001-03-08 | Transgene S.A. | Fibre adenovirale modifiee et utilisations |
| AU1070901A (en) | 1999-09-23 | 2001-04-24 | Genvec, Inc. | Method of treating cells of the prostate prophylactically or therapeutically |
| EP1214098B1 (en) | 1999-09-24 | 2006-11-22 | The Uab Research Foundation | Capsid-modified recombinant adenovirus and methods of use |
| AU1190901A (en) | 1999-09-30 | 2001-04-30 | Trustees Of The University Of Pennsylvania, The | Replication selective adenoviruses for use in cancer therapy |
| EP1223947A4 (en) | 1999-10-15 | 2004-12-08 | Canji Inc | TARGETED VECTORS |
| CA2388807C (en) | 1999-11-12 | 2013-08-06 | Matthew C. Coffey | Viruses for the treatment of cellular proliferative disorders |
| DK1230378T3 (da) | 1999-11-15 | 2007-10-08 | Onyx Pharma Inc | Et onkolytisk adenovirus |
| US6867022B1 (en) | 2000-01-21 | 2005-03-15 | Regents Of The University Of Michigan | Replication deficient adenovirus vectors and methods of making and using them |
| AU2001234981A1 (en) | 2000-02-09 | 2001-08-20 | Genvec, Inc. | Adenoviral capsid containing chimeric protein ix |
| US6692736B2 (en) | 2000-03-24 | 2004-02-17 | Cell Genesys, Inc. | Cell-specific adenovirus vectors comprising an internal ribosome entry site |
| DE60136268D1 (de) | 2000-03-24 | 2008-12-04 | Cell Genesys Inc | Interne ribosomenzugangsstelle-enthaltende zell-spezifische adenovirale vektoren |
| US6911200B2 (en) | 2000-03-24 | 2005-06-28 | Cell Genesys, Inc. | Methods of treating neoplasia with combination of target-cell specific adenovirus, chemotherapy and radiation |
| US20030082146A1 (en) | 2000-04-26 | 2003-05-01 | Van Es Helmuth H. G. | Adenovirus vectors with knobless fibers, and their uses |
| AU2001295193A1 (en) | 2000-05-01 | 2001-11-12 | Novartis Ag | Vectors for ocular transduction and use thereof for genetic therapy |
| US7332337B2 (en) | 2000-05-16 | 2008-02-19 | Galapagos Nv | Viral vectors having tissue tropism for T-lymphocytes, B- and mast cells |
| EP1157999A1 (en) | 2000-05-24 | 2001-11-28 | Introgene B.V. | Methods and means for enhancing skin transplantation using gene delivery vehicles having tropism for primary fibroblasts, as well as other uses thereof |
| EP1284294A4 (en) | 2000-05-26 | 2004-10-13 | Sumitomo Pharma | RECOMBINANT ADENOVIRUS WITH REDUCED SIDE EFFECTS (12/05/01) |
| EP1301612A2 (en) | 2000-05-31 | 2003-04-16 | Genvec, Inc. | Method and composition for targeting an adenoviral vector |
| EP1285079A2 (en) | 2000-05-31 | 2003-02-26 | University of Saskatchewan | Modified bovine adenovirus having altered tropism |
| US7754201B2 (en) | 2000-06-02 | 2010-07-13 | GenPhar, Inc | Method of vaccination through serotype rotation |
| EP1167533A1 (en) | 2000-06-23 | 2002-01-02 | Vereniging Voor Christelijk Wetenschappelijk Onderwijs | Methods and means for the complementation of viral protein expression in stable cell lines |
| US6579522B1 (en) | 2000-06-27 | 2003-06-17 | Genvec, Inc. | Replication deficient adenoviral TNF vector |
| US7022496B2 (en) | 2000-07-14 | 2006-04-04 | The Johns Hopkins University | Use of gene product of adenovirus early region 4 ORF-6 to inhibit repair of double-strand breaks in DNA |
| US20020106382A1 (en) | 2000-07-14 | 2002-08-08 | Young Charles S.H. | Modified adenovirus and uses thereof |
| GB0017720D0 (en) | 2000-07-19 | 2000-09-06 | Got A Gene Ab | Modified virus |
| ATE315095T1 (de) | 2000-08-10 | 2006-02-15 | Crucell Holland Bv | Adenovirenvektoren zur transduktion der chondrozyten |
| US7235233B2 (en) | 2000-09-26 | 2007-06-26 | Crucell Holland B.V. | Serotype 5 adenoviral vectors with chimeric fibers for gene delivery in skeletal muscle cells or myoblasts |
| ATE460472T1 (de) | 2000-12-08 | 2010-03-15 | Life Technologies Corp | Verfahren und zusammensetzungen zur synthese von nukleinsäuremolekülen unter verwendung multipler erkennungsstellen |
| US20030095989A1 (en) | 2000-12-18 | 2003-05-22 | Irving John M. | Chimeric cytolytic viruses for cancer treatment |
| US6635466B2 (en) | 2001-01-09 | 2003-10-21 | University Of Iowa Research Foundation | Adenovirus serotype 30 (Ad30) |
| AU2002250081A1 (en) | 2001-02-14 | 2002-08-28 | Uab Research Foundation | Combined transductional and transcriptional targeting system for improved gene delivery |
| IL152420A0 (en) | 2001-02-23 | 2003-05-29 | Novartis Ag | Novel oncolytic adenoviral vectors |
| JP2005525779A (ja) | 2001-04-02 | 2005-09-02 | バイエル アクチェンゲゼルシャフト | 核酸構築物のトランスフェクションによって、身体サンプルから細胞を特異的に検出、単離および特徴付けするための方法 |
| US20030219899A1 (en) | 2001-04-17 | 2003-11-27 | Nikolay Korokhov | Mosaic adenoviral vectors |
| WO2002083880A1 (en) | 2001-04-17 | 2002-10-24 | Vectorlogics, Inc. | Mosaic adenoviral vectors |
| US20030138405A1 (en) | 2001-04-17 | 2003-07-24 | Juan Fueyo | Conditionally replicative adenovirus to target the Rb and Rb-related pathways |
| JP4399255B2 (ja) | 2001-06-22 | 2010-01-13 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | 細菌の形質転換体を迅速に選別する方法および新規なサルアデノウイルス蛋白質 |
| US6844192B2 (en) | 2001-06-29 | 2005-01-18 | Wake Forest University | Adenovirus E4 protein variants for virus production |
| US6905678B2 (en) | 2001-07-07 | 2005-06-14 | Crucell Holland B.V. | Gene delivery vectors with cell type specificity for mesenchymal stem cells |
| US20030021768A1 (en) | 2001-07-23 | 2003-01-30 | Yuqiao Shen | Viral mutants that selectively replicate in targeted human cancer cells |
| EP1427816A4 (en) | 2001-09-18 | 2004-12-01 | Clontech Lab Inc | METHOD FOR THE PRODUCTION OF ADENOVIRUS VECTORS, BASED ON A SPECIFIC RECOMBINASE |
| US7569217B2 (en) | 2001-09-24 | 2009-08-04 | University Of Saskatchewan | Porcine adenovirus E1 and E4 regions |
| WO2003029448A1 (en) | 2001-09-29 | 2003-04-10 | Yun, Chae-Ok | Recombinant adenovirus with enhanced therapeutic effect and pharmaceutical composition comprising said recombinant adenovirus |
| HU230364B1 (hu) | 2001-11-21 | 2016-03-29 | The Trustees Of The University Of Pennsylvania | Simian adenovírus nukleinsav és aminosav-szekvencia, azt tartalmazó vektorok, és eljárások annak alkalmazására |
| CN100475966C (zh) | 2001-11-23 | 2009-04-08 | 上海三维生物技术有限公司 | 具有肿瘤细胞特异性感染和转基因表达能力的新型腺病毒 |
| EP1327688A1 (en) | 2002-01-14 | 2003-07-16 | Vereniging Voor Christelijk Wetenschappelijk Onderwijs | Adenoviruses with enhanced lytic potency |
| US20040002060A1 (en) | 2002-01-24 | 2004-01-01 | Novartis Ag | Fiber shaft modifications for efficient targeting |
| CA2474777A1 (en) | 2002-02-01 | 2003-08-07 | Transgene S.A. | Adenoviral vectors for modulating the cellular activities associated with pods |
| US20030220284A1 (en) | 2002-02-22 | 2003-11-27 | Patricia Yotnda | Delivery of adenoviral DNA in a liposomal formulation for treatment of disease |
| US20040005710A1 (en) | 2002-03-09 | 2004-01-08 | Ho-Sun Son | Method for producing recombinant viruses using site-specific recombination |
| EP1605053A1 (en) | 2002-03-26 | 2005-12-14 | Oncolytics Biotech Inc. | Use of adenoviruses mutated in the VA genes for cancer treatment |
| ATE447037T1 (de) | 2002-04-25 | 2009-11-15 | Crucell Holland Bv | Mittel und verfahren zur herstellung von adenovirusvektoren |
| WO2003092579A2 (en) | 2002-04-29 | 2003-11-13 | Hadasit Medical Research Services And Development Company Ltd. | Compositions and methods for treating cancer with an oncolytic viral agent |
| AU2003302216A1 (en) | 2002-05-08 | 2004-06-23 | Virxsys Corporation | Use of spliceosome mediated rna trans-splicing to confer cell selective replication to adenoviruses |
| KR101083450B1 (ko) | 2002-05-27 | 2011-11-16 | 페르 손네 홀름 | 아데노바이러스 및 그를 코딩하는 핵산의 신규 용도 |
| EP1523563A2 (en) | 2002-07-10 | 2005-04-20 | Transgene S.A. | Modified adenoviral fiber with ablated to cellular receptors |
| AU2003253992A1 (en) | 2002-07-18 | 2004-02-09 | Robert P. Bennett | Viral vectors containing recombination sites |
| US7364727B2 (en) | 2002-07-22 | 2008-04-29 | Cell Genesys, Inc. | Metastatic colon cancer specific promoter and uses thereof |
| US20040106194A1 (en) | 2002-08-22 | 2004-06-03 | Bett Andrew J. | Methods for propagating adenovirus and virus produced thereby |
| EP1545627A4 (en) | 2002-10-01 | 2006-12-27 | Univ Duke | TARGETED TUMOR THERAPY THROUGH THE USE OF RECOMBINANT ADENOVIRUS VECTORS FOR SELECTIVE REPLICATION IN HYPOXIC TUMOR REGIONS |
| EP1413586A1 (en) | 2002-10-21 | 2004-04-28 | Centre National De La Recherche Scientifique (Cnrs) | Regulation of the Cre recombinase using a dissociation/re-association system of said recombinase |
| US20040102382A1 (en) | 2002-11-27 | 2004-05-27 | Transgene, S.A. | Targeting peptides |
| JP2006513714A (ja) | 2003-03-17 | 2006-04-27 | メルク エンド カムパニー インコーポレーテッド | アデノウイルス血清型24ベクター、核酸およびそれにより製造されたウイルス |
| US20040191761A1 (en) | 2003-03-27 | 2004-09-30 | Routes John M. | Modified adenoviral E1A constructs and methods of use thereof |
| CA2519680A1 (en) | 2003-03-28 | 2004-11-18 | The Scripps Research Institute | Adenovirus particles with enhanced infectivity of dendritic cells and particles with decreased infectivity of hepatocytes |
| WO2004097016A1 (en) | 2003-03-28 | 2004-11-11 | Merck & Co., Inc. | Adenovirus serotype 34 vectors, nucleic acids and virus produced thereby |
| WO2004087930A1 (en) | 2003-03-28 | 2004-10-14 | Saint Louis University | Adenovirus replication-competent vectors expressing trail |
| US20050095705A1 (en) | 2003-04-15 | 2005-05-05 | Michael Kadan | Method for production of oncolytic adenoviruses |
| US20060281090A1 (en) | 2003-05-01 | 2006-12-14 | University Of Washington Uw Tech Transfer- Invention Licensing | Capsid-modified adenovirus vectors and methods of using the same |
| EP1625222A2 (en) | 2003-05-14 | 2006-02-15 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Broadening adenovirus tropism |
| US20050079158A1 (en) | 2003-06-05 | 2005-04-14 | Shenzhen Allucks Biotech Co., Ltd. | Construct of anti-cancer recombinant adenovirus, method for preparing the same and use thereof |
| MXPA05013234A (es) | 2003-06-10 | 2006-03-09 | Univ Saskatchewan | Proteinas de capside de adenovirus quimericas. |
| JP2007531507A (ja) | 2003-06-11 | 2007-11-08 | ザ スクリップス リサーチ インスティテュート | 効率的な受容体結合のための修飾型線維タンパク質 |
| US7291498B2 (en) | 2003-06-20 | 2007-11-06 | The Trustees Of The University Of Pennsylvania | Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses |
| EP1636370B1 (en) | 2003-06-20 | 2014-04-16 | The Trustees of The University of Pennsylvania | Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses |
| EP1646717A4 (en) | 2003-07-18 | 2006-12-20 | Onyx Pharma Inc | ADENOVIRAL VECTORS OF SUB-GROUP B FOR THE TREATMENT OF DISEASES |
| WO2005012537A2 (en) | 2003-07-25 | 2005-02-10 | Genvec, Inc. | Adenoviral vector-based vaccines |
| US20050186178A1 (en) | 2003-08-28 | 2005-08-25 | Ennist David L. | Oncolytic adenoviral vectors encoding GM-CSF |
| WO2005030261A1 (en) | 2003-08-28 | 2005-04-07 | Cell Genesys, Inc. | Oncolytic adenoviral vectors encoding gm-csf |
| EP1664099A2 (en) | 2003-09-09 | 2006-06-07 | Niels Rudi Pedersen | Adenoviral epitopes |
| US7482156B2 (en) | 2003-10-15 | 2009-01-27 | Cell Genesys, Inc. | Hepatocellular carcinoma specific promoter and uses thereof |
| WO2005051430A1 (de) | 2003-11-14 | 2005-06-09 | Per Sonne Holm | Neue verwendung von adenoviren und dafür codierenden nukleinsäuren |
| WO2005048950A2 (en) | 2003-11-17 | 2005-06-02 | Biomune, Inc. | Tumor and infectious disease therapeutic compositions |
| ATE546531T1 (de) | 2003-12-31 | 2012-03-15 | Kalobios Inc | Transaktivierungssystem für säugerzellen |
| WO2005075506A1 (en) | 2004-01-09 | 2005-08-18 | The Scripps Research Institute | Identification of endogenous trimerization domains in the adenovirus fiber protein that allow detargeting and retargeting of viral vectors |
| DE602005017743D1 (de) | 2004-01-23 | 2009-12-31 | Angeletti P Ist Richerche Bio | Impfstoffträger für schimpansen-adenovirus |
| US20050201936A1 (en) | 2004-02-12 | 2005-09-15 | Wold William S.M. | Models for viral-based cancer therapy |
| WO2005086922A2 (en) | 2004-03-10 | 2005-09-22 | Board Of Regents, University Of Texas System | Oncolytic adenovirus armed with therapeutic genes |
| US7473418B2 (en) | 2004-03-25 | 2009-01-06 | Cell Genesys, Inc. | Pan cancer oncolytic vectors and methods of use thereof |
| EP1729817B1 (en) | 2004-03-30 | 2014-03-05 | Industry-Academic Cooperation Foundation | Gene delivery system containing relaxin gene and pharmaceutical composition using relaxin |
| US20080292592A1 (en) | 2004-04-30 | 2008-11-27 | Sunil Chada | Oncolytic Adenovirus Armed with Therapeutic Genes |
| EP1743041B1 (en) | 2004-05-03 | 2012-06-27 | Stefan Kochanek | Modified viral vector particles |
| GB0411428D0 (en) | 2004-05-21 | 2004-06-23 | Got A Gene Ab | Vectors |
| ATE491799T1 (de) | 2004-05-26 | 2011-01-15 | Bayer Schering Pharma Ag | Chimäre adenoviren zur verwendung in der krebsbehandlung |
| US20050271622A1 (en) | 2004-06-03 | 2005-12-08 | Shenzhen Allucks Biotech Co., Ltd. | Construct of tumor-selective recombinant adenovirus, method for preparing the same and use thereof |
| WO2005117993A2 (en) | 2004-06-04 | 2005-12-15 | Genvec, Inc. | Method of using adenoviral vectors with improved safety and efficacy for the treatment of cancer |
| CN100361710C (zh) | 2004-06-07 | 2008-01-16 | 成都康弘生物科技有限公司 | 肿瘤细胞专一表达免疫调节因子gm-csf的溶瘤性腺病毒重组体的构建及其应用 |
| US20060292682A1 (en) | 2004-07-22 | 2006-12-28 | Hawkins Lynda K | Addition of transgenes into adenoviral vectors |
| GB0416487D0 (en) | 2004-07-23 | 2004-08-25 | Isis Innovation | Modified virus |
| US7776322B2 (en) | 2004-08-16 | 2010-08-17 | Stefan Kochanek | Modified viral vector particles |
| JP2008511336A (ja) | 2004-09-01 | 2008-04-17 | アメリカ合衆国 | 免疫原性が増加したアデノウイルスベクターをインビボで用いる方法 |
| US7943373B2 (en) | 2004-09-29 | 2011-05-17 | Oncolys Biopharma, Inc. | Telomelysin/GFP-expressing recombinant virus |
| AU2005293568B2 (en) | 2004-10-13 | 2010-10-28 | Beth Israel Deaconess Medical Center Inc. | Improved adenoviral vectors and uses thereof |
| US20070122817A1 (en) | 2005-02-28 | 2007-05-31 | George Church | Methods for assembly of high fidelity synthetic polynucleotides |
| CA2589430A1 (en) | 2004-10-25 | 2007-04-12 | Novartis Ag | Torc polynucleotides and polypeptides, and methods of use |
| IL166049A0 (en) | 2004-12-30 | 2006-01-15 | Gavish Galilee Bio Appl Ltd | Method for obtaining modified proteins and viruseswith intact native binding |
| WO2006070024A2 (de) | 2004-12-31 | 2006-07-06 | Per Sonne Holm | E1 -minus adenoviren und deren verwendung |
| EP1831382B1 (en) | 2004-12-31 | 2023-01-18 | Per Sonne Holm | Method for reversing multiple resistance in animal cells |
| WO2006086357A2 (en) | 2005-02-10 | 2006-08-17 | Merck & Co., Inc. | Adenovirus serotype 36 vectors, nucleic acid and viruses produced thereby |
| WO2006086284A2 (en) | 2005-02-11 | 2006-08-17 | Merck & Co., Inc. | Adenovirus serotype 26 vectors, nucleic acid and viruses produced thereby |
| KR100747646B1 (ko) | 2005-02-25 | 2007-08-08 | 연세대학교 산학협력단 | 데코린 유전자를 포함하는 유전자 전달 시스템 및 이를 포함하는 약제학적 항종양 조성물 |
| WO2006119449A2 (en) | 2005-05-04 | 2006-11-09 | Vectorlogics, Inc. | Modified adenovirus containing a stabilized antibody |
| WO2007050128A2 (en) | 2005-05-31 | 2007-05-03 | Vectorlogics, Inc. | Shielded adenoviral vectors and methods of use |
| JP5475279B2 (ja) | 2005-06-17 | 2014-04-16 | イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・エルレ・エルレ | C型肝炎ウイルス核酸ワクチン |
| US8765146B2 (en) | 2005-08-31 | 2014-07-01 | Genvec, Inc. | Adenoviral vector-based malaria vaccines |
| KR100723009B1 (ko) | 2005-11-30 | 2007-05-29 | 한국원자력연구원 | 인간 p31 유전자를 함유하는 악성 종양 치료용 약학적조성물 |
| ES2304281B1 (es) | 2006-02-01 | 2009-08-12 | Dnatrix Inc. | Adenovirus oncoliticos para el tratamiento del cancer. |
| WO2007094653A1 (en) | 2006-02-13 | 2007-08-23 | Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patientenzorg | Adenovirus particles having a chimeric adenovirus spike protein, use thereof and methods for producing such particles. |
| WO2007103825A2 (en) | 2006-03-02 | 2007-09-13 | The Board Of Regents Of The University Of Texas System | Combination therapy with oncolytic adenovirus |
| US20070292954A1 (en) | 2006-04-21 | 2007-12-20 | The Brigham And Women's Hospital, Inc. | Generation of recombinant DNA by sequence-and ligation-independent cloning |
| ATE455558T1 (de) | 2006-04-28 | 2010-02-15 | Univ Pennsylvania | Modifiziertes adenovirus-hexon-protein und anwendungen davon |
| US20080242608A1 (en) | 2006-06-02 | 2008-10-02 | Azad Bonni | Methods and compositions for treating and preventing neurologic disorders |
| US20090280089A1 (en) | 2006-06-19 | 2009-11-12 | Institut Gustave Roussy | Inhibition of the liver tropism of adenoviral vectors |
| JP2008048621A (ja) | 2006-08-22 | 2008-03-06 | Chiba Prefecture | キメラ型アデノウイルスとその作製方法並びにそれを用いた医薬 |
| GR20060100496A (el) | 2006-09-01 | 2008-04-15 | Παρθενιος Μπουλικας | ΛΙΠΟΣΩΜΑΤΙΚΑ ΕΓΚΑΨΥΛΙΩΜΕΝΟΙ ΦΟΡΕΙΣ-ΥΒΡΙΔΙΟΥ ΑΔΕΝΟΙΟΥ - ΙΟΥ SEMLIKI FOREST (SFV), ΠΟΥ ΦΕΡΕΙ ΚΑΤΑΣΚΕΥΑΣΜΑΤΑ RNAi ΚΑΙ ΘΕΡΑΠΕΥΤΙΚΑ ΓΟΝΙΔΙΑ ΠΟΥ ΧΡΗΣΙΜΟΠΟΙΟΥΝΤΑΙ ΕΝΑΝΤΙΟΝ ΣΤΟΧΩΝ ΚΑΡΚΙΝΟΥ ΚΑΙ ΑΛΛΩΝ ΑΣΘΕΝΕΙΩΝ |
| WO2008067025A2 (en) | 2006-09-29 | 2008-06-05 | Evanston Northwestern Healthcare | Oncolytic adenoviruses and uses thereof |
| US20100272753A1 (en) | 2006-10-26 | 2010-10-28 | The Johns Hopkins University | Recombinant Adenovirus Vaccines |
| WO2008065054A1 (en) | 2006-11-28 | 2008-06-05 | Nerviano Medical Sciences S.R.L. | Tricyclic indoles and (4,5-dihydro) indoles |
| WO2008095168A2 (en) | 2007-02-01 | 2008-08-07 | University Of Chicago | Compositions and methods related to a recombinant adenoviral vector that targets il 13 receptors |
| ATE510907T1 (de) | 2007-03-14 | 2011-06-15 | Inst Catala D Oncologia | Adenovirus mit mutationen in der domäne des e3- 19k-proteins zur retention im endoplasmatischen retikulum und verwendung in der krebsbehandlung |
| US20090081639A1 (en) | 2007-05-31 | 2009-03-26 | Phil Hill | Assay for sensitivity to chemotherapeutic agents |
| WO2009065800A1 (en) | 2007-11-20 | 2009-05-28 | Crucell Holland B.V. | Recombinant human adenoviruses for eliciting mucosal immune responses |
| AU2008331905B2 (en) | 2007-11-28 | 2014-09-18 | The Trustees Of The University Of Pennsylvania | Simian subfamily B adenovirus SAdV-28 and uses thereof |
| CA2706258C (en) | 2007-11-28 | 2017-06-06 | The Trustees Of The University Of Pennsylvania | Simian subfamily e adenoviruses sadv-39, -25.2, -26, -30, -37, and -38 and uses thereof |
| KR101614369B1 (ko) | 2007-11-28 | 2016-04-21 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 유인원 아과 c 아데노바이러스 sadv-40, -31, 및 -34 및 그것의 사용 |
| CN102014948A (zh) | 2008-02-07 | 2011-04-13 | 安德鲁·贝克 | 腺病毒向性的调节 |
| JP5661476B2 (ja) | 2008-03-04 | 2015-01-28 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | サルアデノウイルスSAdV−36、−42.1、−42.2および−44ならびにそれらの用途 |
| WO2009117656A2 (en) | 2008-03-21 | 2009-09-24 | Vectorlogics,Inc. | Capsid-incorporated antigen for novel adenovirus vaccine |
| EP2300053A1 (en) | 2008-06-04 | 2011-03-30 | Cornell University | Vaccines for prevention and treatment of addiction |
| AU2009260782B2 (en) | 2008-06-19 | 2014-12-11 | Millennium Pharmaceuticals, Inc. | Thiophene or thiazole derivatives and their use as PI3K inhibitors |
| KR101034811B1 (ko) | 2008-08-25 | 2011-05-16 | 단국대학교 산학협력단 | 조직 특이적 프로모터와 암 특이 유전자를 타겟팅하는트랜스-스플라이싱 라이보자임을 포함하는 재조합아데노바이러스 및 이의 용도 |
| US8808986B2 (en) | 2008-08-27 | 2014-08-19 | Gen9, Inc. | Methods and devices for high fidelity polynucleotide synthesis |
| WO2010037027A2 (en) | 2008-09-26 | 2010-04-01 | Auburn University | Immunization of avians by mucosal administration of non-replicating vectored vaccines |
| US8940290B2 (en) | 2008-10-31 | 2015-01-27 | The Trustees Of The University Of Pennsylvania | Simian adenoviruses SAdV-43, -45, -46, -47, -48, -49, and -50 and uses thereof |
| US9345787B2 (en) | 2008-12-22 | 2016-05-24 | Targovax Oy | Adenoviral vectors and methods and uses related thereto |
| CN102264760B (zh) | 2008-12-22 | 2017-03-22 | 昂克斯治疗有限公司 | 溶瘤性腺病毒载体及与其相关的方法和用途 |
| KR101763093B1 (ko) | 2009-02-02 | 2017-07-28 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 시미안 아데노바이러스 핵산- 및 아미노산-서열, 이를 포함하는 벡터 및 이의 용도 |
| SI2403951T1 (sl) | 2009-03-02 | 2016-04-29 | The Regents Of The University Of California | Tumorsko selektivni mutanti adenovirusa e1a in e1b |
| ES2385251B1 (es) | 2009-05-06 | 2013-05-06 | Fundació Privada Institut D'investigació Biomèdica De Bellvitge | Adenovirus oncolíticos para el tratamiento del cáncer. |
| CN102575232B (zh) | 2009-05-29 | 2015-07-22 | 宾夕法尼亚大学托管会 | 猿腺病毒41及其应用 |
| AU2010278797A1 (en) | 2009-07-31 | 2012-03-15 | Paxvax, Inc. | Adenoviral-based vectors |
| WO2011022002A1 (en) | 2009-08-18 | 2011-02-24 | The Rockefeller University | Modification of recombinant adenovirus with immunogenic plasmodium circumsporozoite protein epitopes |
| US9555089B2 (en) | 2009-08-18 | 2017-01-31 | The Rockefeller University | Modification of recombinant adenovirus with immunogenic plasmodium circumsporozoite protein epitopes |
| KR101248912B1 (ko) | 2009-12-31 | 2013-03-29 | 한양대학교 산학협력단 | 항혈관신생 활성을 가지는 재조합 아데노바이러스 |
| US9163261B2 (en) | 2010-02-22 | 2015-10-20 | Koteswara Rao KOLLIPARA | Adeno-associated virus 2/8—micro RNA-101 therapy for liver cancer |
| CN102191245B (zh) | 2010-03-15 | 2013-11-13 | 浙江东方基因生物制品有限公司 | 应用肿瘤特异性启动子表达报告基因来检测循环血中肿瘤细胞的方法和试剂 |
| ES2887335T3 (es) | 2010-03-17 | 2021-12-22 | Univ Cornell | Vacuna contra las drogas de abuso basada en adenovirus alterado |
| EP2558481B1 (en) | 2010-04-14 | 2017-12-20 | Mogam Biotechnology Research Institute | Hexon isolated from simian adenovirus serotype 19, hypervariable region thereof and chimeric adenovirus using the same |
| WO2011133040A2 (en) | 2010-04-23 | 2011-10-27 | Orca Therapeutics B.V. | Replication-competent adenoviruses |
| WO2011136400A1 (en) | 2010-04-26 | 2011-11-03 | Green Cross Corporation | Tumor-specific promoter and oncolytic virus vector comprising the same |
| JP6499825B2 (ja) | 2010-06-10 | 2019-04-10 | ユニバーシティ オブ ワシントン スルー イッツ センター フォー コマーシャリゼーション | デスモグレイン2(dsg2)とのアデノウイルスの相互作用のための方法およびシステム |
| WO2012003287A2 (en) | 2010-06-30 | 2012-01-05 | The Johns Hopkins University | Compositions and methods for detecting and quantifying circulating tumor cells ctcs |
| BR112013003579A2 (pt) | 2010-08-16 | 2016-06-07 | Salk Inst For Biological Studi | adenovírus, células, e, métodos para tratar câncer |
| JP5981916B2 (ja) | 2010-08-16 | 2016-09-07 | ソーク インスティテュート フォー バイオロジカル スタディーズ | アデノウイルスの構築方法 |
| WO2012022496A2 (en) | 2010-08-19 | 2012-02-23 | Per Sonne Holm | Method for killing tumor stem cells |
| BR112013006669A2 (pt) | 2010-09-24 | 2019-09-24 | Oncos Therapeutics Oy | vetores adenovirais oncolíticos e métodos e usos relacionados aos mesmos |
| CN103221544A (zh) | 2010-09-24 | 2013-07-24 | 昂克斯治疗有限公司 | 编码单克隆抗-ctla-4抗体的溶瘤腺病毒载体 |
| EP2643465B1 (en) | 2010-11-23 | 2016-05-11 | The Trustees Of The University Of Pennsylvania | Subfamily e simian adenovirus a1321 and uses thereof |
| WO2012083297A2 (en) | 2010-12-17 | 2012-06-21 | Genvec, Inc. | Adenoviral vectors with modified hexon regions |
| US8920813B2 (en) | 2010-12-20 | 2014-12-30 | Genvec, Inc. | Adenoviral vector-based dengue fever vaccine |
| CN102174479B (zh) | 2011-03-02 | 2013-04-03 | 北京锤特生物科技有限公司 | 靶向性治疗人肿瘤的溶肿瘤腺病毒及其应用 |
| WO2012132369A1 (ja) | 2011-03-25 | 2012-10-04 | 国立大学法人鹿児島大学 | 癌幹細胞を標的とするウイルスベクター |
| WO2012156933A1 (en) | 2011-05-16 | 2012-11-22 | Institut Gustave Roussy | Combination of oncolytic adenoviruses with histone deacetylase inhibitors |
| WO2012162342A2 (en) | 2011-05-23 | 2012-11-29 | The Wistar Institute Of Anatomy And Biology | Influenza vaccines containing modified adenovirus vectors |
| GB201108879D0 (en) | 2011-05-25 | 2011-07-06 | Isis Innovation | Vector |
| CN102260712B (zh) | 2011-05-31 | 2013-10-02 | 北京锤特生物科技有限公司 | 溶肿瘤能力增强的B型人腺病毒Ad11突变体的构建和应用 |
| US20140199688A1 (en) | 2011-08-23 | 2014-07-17 | National Institute Of Biomedical Innovation | Conditionallly replication-competent adenovirus |
| WO2013036791A2 (en) | 2011-09-09 | 2013-03-14 | Beth Israel Deaconess Medical Center, Inc. | Modified adenoviral vectors and methods of treatment using same |
| IN2014DN03061A (enExample) | 2011-10-05 | 2015-05-15 | Genvec Inc | |
| US8859256B2 (en) * | 2011-10-05 | 2014-10-14 | Genelux Corporation | Method for detecting replication or colonization of a biological therapeutic |
| FI123955B (en) | 2011-11-25 | 2014-01-15 | Oncos Therapeutics Ltd | Oncolytic adenovirus |
| EP2798069B1 (en) | 2011-12-15 | 2017-03-29 | Washington University | Porcine knob xenotype chimeric adenoviral vector for dendritic cell infection |
| US11155599B2 (en) * | 2012-02-02 | 2021-10-26 | Board Of Regents, The University Of Texas System | Adenoviruses expressing heterologous tumor-associated antigens |
| DK2825640T3 (en) | 2012-03-12 | 2016-08-01 | Crucell Holland Bv | BATCHES OF RECOMBINANT ADENOVIRUS WITH CHANGED TERMINAL END |
| AU2013232101B2 (en) | 2012-03-13 | 2018-01-04 | Salk Institute For Biological Studies | Selective cell targeting using adenovirus and chemical dimers |
| IN2014DN06898A (enExample) | 2012-03-14 | 2015-05-15 | Salk Inst For Biological Studi | |
| US9017672B2 (en) | 2012-05-11 | 2015-04-28 | Immunicum Aktiebolag | Hexon Tat-PTD modified adenovirus and uses thereof |
| KR20150014505A (ko) | 2012-05-18 | 2015-02-06 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 아과 e 원숭이 아데노바이러스 a1302, a1320, a1331 및 a1337 및 이것들의 사용 |
| JP6162224B2 (ja) | 2012-05-24 | 2017-07-12 | クルセル ホランド ベー ヴェー | 血管組織の形質導入のためのアデノウイルスベクター |
| EP2855669B1 (en) | 2012-05-29 | 2018-10-10 | GenVec, Inc. | Modified serotype 28 adenoviral vectors |
| AU2013203696A1 (en) * | 2012-06-25 | 2014-01-16 | University Of Canberra | Recombinant Viral Vectors and Uses Therefor |
| CN105008535B (zh) | 2012-09-25 | 2018-10-16 | 华盛顿大学商业化中心 | 桥粒芯糖蛋白2(dsg2)结合蛋白质及其用途 |
| KR101429696B1 (ko) | 2012-11-21 | 2014-08-13 | 국립암센터 | 안전성 및 항암활성이 증가된 재조합 아데노바이러스 및 이의 용도 |
| US20160090574A1 (en) | 2013-02-28 | 2016-03-31 | Psioxus Therapuetics Limited | A process for the production of adenovirus |
| WO2014160475A1 (en) | 2013-03-13 | 2014-10-02 | Aboody Karen S | Tropic cell based virotherapy for the treatment of cancer |
| JP6576326B2 (ja) | 2013-03-14 | 2019-09-18 | ソーク インスティテュート フォー バイオロジカル スタディーズ | 腫瘍溶解性アデノウイルス組成物 |
| ES3011466T3 (en) | 2013-04-18 | 2025-04-07 | Tilt Biotherapeutics Oy | Enhanced adoptive cell therapy |
| AU2014281826B2 (en) | 2013-06-18 | 2019-10-17 | Board Of Regents, The University Of Texas System | Treatment of brain cancer with oncolytic adenovirus |
| BR112016006564B1 (pt) | 2013-09-24 | 2023-11-21 | University Of Washington Through Its Center For Commercialization | Polipeptídeo de fibra adb-2/3 recombinante e composição farmacêutica |
| CA2931322A1 (en) | 2013-11-22 | 2015-05-28 | Dnatrix, Inc. | Adenovirus expressing immune cell stimulatory receptor agonist(s) |
| GB201415579D0 (en) | 2014-09-03 | 2014-10-15 | Psioxus Therapeutics Ltd | A process |
| GB201406608D0 (en) * | 2014-04-12 | 2014-05-28 | Psioxus Therapeutics Ltd | Virus |
| EP2940128A1 (en) | 2014-04-30 | 2015-11-04 | Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Adenovirus comprising an albumin-binding moiety |
| ES2714921T3 (es) | 2014-05-19 | 2019-05-30 | Valo Therapeutics Oy | Adenovirus oncolíticos recubiertos para vacunas contra el cáncer |
| WO2015182574A1 (ja) | 2014-05-28 | 2015-12-03 | 国立大学法人岡山大学 | Reic遺伝子を発現する制限増殖型アデノウイルス |
| KR102814615B1 (ko) | 2014-09-24 | 2025-05-28 | 솔크 인스티튜트 포 바이올로지칼 스터디즈 | 종양 살상 바이러스 및 이의 사용방법 |
| US10617729B2 (en) | 2014-12-24 | 2020-04-14 | The Uab Research Foundation | Multitargeting onocolytic adenovirus, methods of use, and methods of making |
| US10376549B2 (en) | 2015-01-20 | 2019-08-13 | Adcure Biotechnologies, Llc. | Detargeted adenovirus variants and related methods |
| WO2016141073A1 (en) | 2015-03-02 | 2016-09-09 | Washington University | Induction of pacemaker-like cells from cardiomyocytes |
| CN107406859A (zh) | 2015-03-17 | 2017-11-28 | 倾斜生物医疗公司 | 编码双特异性抗体的溶瘤腺病毒及与其相关的方法和用途 |
| EP3072900A1 (en) | 2015-03-27 | 2016-09-28 | Medizinische Hochschule Hannover | Anti-tumour medicament based on adenovirus |
| GB201505860D0 (en) | 2015-04-07 | 2015-05-20 | Agalimmune Ltd | Therapeutic compositions and methods of use for treating cancer |
| GB201513176D0 (en) | 2015-07-27 | 2015-09-09 | Glaxosmithkline Biolog Sa | Novel methods for inducing an immune response |
| EP3329934B1 (en) | 2015-09-01 | 2021-03-24 | Genemedicine Co., Ltd. | Antitumor immunity enhancing composition containing adenovirus simultaneously expressing il-12 and shvegf |
| AU2016333996B2 (en) | 2015-10-05 | 2020-05-28 | Salk Institute For Biological Studies | Synthetic adenoviruses with tropism to damaged tissue for use in promoting wound repair and tissue regeneration |
| ES2994611T3 (en) | 2015-10-19 | 2025-01-27 | Cg Oncology Inc | Methods of treating solid or lymphatic tumors by combination therapy |
| US11246896B2 (en) | 2015-10-28 | 2022-02-15 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Tumor-specific adenovirus vectors and therapeutic uses |
| JP7054527B2 (ja) | 2016-02-23 | 2022-04-14 | ソーク インスティテュート フォー バイオロジカル スタディーズ | アデノウイルスの複製動態を測定するための高スループットアッセイ |
| KR20220163505A (ko) | 2016-02-23 | 2022-12-09 | 솔크 인스티튜트 포 바이올로지칼 스터디즈 | 바이러스 동역학에 미치는 영향 최소화를 위한 치료용 아데노바이러스의 외인성 유전자 발현 |
| PL3426271T3 (pl) | 2016-03-10 | 2025-11-24 | Cg Oncology, Inc. | Sposoby leczenia guzów litych terapią skojarzoną |
| US20170314044A1 (en) | 2016-05-02 | 2017-11-02 | Regents Of The University Of Minnesota | Adenovirus constructs and methods |
| WO2017205423A1 (en) | 2016-05-23 | 2017-11-30 | Washington University | Pulmonary targeted cas9/crispr for in vivo editing of disease genes |
| EP3463405A4 (en) | 2016-05-27 | 2020-02-26 | DNAtrix, Inc. | ADENOVIRUS AND IMMUNO MODULATOR COMBINATION THERAPY |
| GB2549809C (en) | 2016-06-23 | 2022-11-30 | Univ Oxford Innovation Ltd | Vector |
| US11155832B2 (en) | 2016-09-30 | 2021-10-26 | Genvec, Inc. | Adenovectors for delivery of therapeutic genetic material into T cells |
| FI20165814A7 (fi) | 2016-10-27 | 2018-04-28 | Tilt Biotherapeutics Oy | Interleukiini 8 (il-8) prognostisena ja ennustavana biomarkkerina ja koostumukset ja vektorit käytettäväksi onkolyyttisessa immunoterapiassa |
| US20190275092A1 (en) | 2016-11-01 | 2019-09-12 | Dnatrix, Inc. | Combination therapy for treatment of brain cancers |
| WO2018083258A1 (en) | 2016-11-03 | 2018-05-11 | Psioxus Therapeutics Limited | Oncolytic adenovirus encoding at least three transgenes |
| WO2018083259A1 (en) | 2016-11-03 | 2018-05-11 | Psioxus Therapeutics Limited | Oncolytic adenovirus encoding transgenes |
| WO2018083257A1 (en) | 2016-11-03 | 2018-05-11 | Psioxus Therapeutics Limited | Oncolytic adenovirus encoding transgenes |
| CN109982709A (zh) | 2016-11-17 | 2019-07-05 | Vcn生物科学有限公司 | 病毒载体在治疗视网膜母细胞瘤中的用途 |
| CN110036020A (zh) | 2016-12-09 | 2019-07-19 | 葛兰素史密丝克莱恩生物有限公司 | 具有狂犬病病毒抗原的黑猩猩腺病毒构建体 |
| GB201620968D0 (en) | 2016-12-09 | 2017-01-25 | Glaxosmithkline Biologicals Sa | Adenovirus polynucleotides and polypeptides |
| JP2019536468A (ja) | 2016-12-12 | 2019-12-19 | ソーク インスティテュート フォー バイオロジカル スタディーズ | 腫瘍を標的にする合成アデノウイルスおよびその使用 |
| US10232053B2 (en) | 2016-12-30 | 2019-03-19 | Trieza Therapeutics, Inc. | Immunomodulatory oncolytic adenoviral vectors, and methods of production and use thereof for treatment of cancer |
| WO2018125970A1 (en) | 2016-12-30 | 2018-07-05 | Salk Institute For Biological Studies | Synthetic adenoviruses targeting bone tissue and uses thereof |
| KR20190128634A (ko) | 2017-01-30 | 2019-11-18 | 에피센트알엑스, 인코포레이티드 | 다중 트랜스진 재조합 아데노바이러스 |
| EA201991806A1 (ru) | 2017-01-30 | 2020-02-13 | Эписентарикс, Инк. | Опухоль-селективные мутанты tata-бокса и caat-бокса |
| EP3610003A4 (en) | 2017-04-10 | 2021-01-06 | EpicentRx, Inc. | RECOMBINANT VIRUS PRODUCTION PROCESS |
| EA201990822A1 (ru) | 2017-04-12 | 2020-01-09 | Эписентарикс, Инк. | Иммуномодулирующие слитые белки |
| SG11201909749PA (en) | 2017-04-21 | 2019-11-28 | Baylor College Medicine | Oncolytic virotherapy and immunotherapy |
| WO2018201017A1 (en) | 2017-04-27 | 2018-11-01 | Washington University | Dendritic cell targeted adenovirus for vaccination |
| WO2018204677A1 (en) | 2017-05-04 | 2018-11-08 | Epicentrx, Inc. | Oncolytic adenovirus formulation |
| AU2018271999A1 (en) | 2017-05-24 | 2020-01-16 | Epicentrx, Inc. | Anti-angiogenic adenovirus |
| US11542312B2 (en) | 2017-06-19 | 2023-01-03 | Medicenna Therapeutics, Inc. | IL-2 superagonists in combination with anti-PD-1 antibodies |
| US11649467B2 (en) | 2017-07-21 | 2023-05-16 | Glaxosmithkline Biologicals Sa | Chikungunya virus antigen constructs |
| EP3460052B1 (en) | 2017-09-20 | 2019-10-30 | Immunicum AB | Improved allogeneic dendritic cells for use in cancer treatment |
| US12123027B2 (en) | 2017-10-12 | 2024-10-22 | Ascend Advanced Therapies Limited | Life-cycle-defective adenovirus helper viruses, their production and use for producing rAAV |
| KR20200083510A (ko) | 2017-10-31 | 2020-07-08 | 얀센 백신스 앤드 프리벤션 비.브이. | 아데노바이러스 및 이의 용도 |
| WO2019086461A1 (en) | 2017-10-31 | 2019-05-09 | Janssen Vaccines & Prevention B.V. | Adenovirus vectors and uses thereof |
| MX2020004488A (es) | 2017-10-31 | 2020-08-13 | Janssen Vaccines & Prevention Bv | Adenovirus y usos de estos. |
| KR20200077559A (ko) | 2017-10-31 | 2020-06-30 | 얀센 백신스 앤드 프리벤션 비.브이. | 아데노바이러스 및 이의 용도 |
| GB201802539D0 (en) | 2018-02-16 | 2018-04-04 | Univ College Cardiff Consultants Ltd | Modified adenoviruses |
| GB201804468D0 (en) | 2018-03-21 | 2018-05-02 | Valo Therapeutics Oy | PeptiCRAd Cancer Therapy |
| GB201804473D0 (en) | 2018-03-21 | 2018-05-02 | Valo Therapeutics Oy | Modified oncolytic adenoviruses |
| WO2019191494A1 (en) | 2018-03-28 | 2019-10-03 | Epicentrx, Inc. | Personalized cancer vaccines |
| AU2019251356B2 (en) | 2018-04-09 | 2025-06-12 | Salk Institute For Biological Studies | Oncolytic adenovirus compositions with enhanced replication properties |
| WO2019202118A1 (en) | 2018-04-20 | 2019-10-24 | Baylor College Of Medicine | Oncolytic virotherapy and immunotherapy |
| EP3807298A1 (en) | 2018-06-12 | 2021-04-21 | GlaxoSmithKline Biologicals S.A. | Adenovirus polynucleotides and polypeptides |
| WO2020014539A1 (en) | 2018-07-11 | 2020-01-16 | Epicentrx, Inc. | Methods and compositions for targeting cancer cells for treatment |
| KR20210089135A (ko) | 2018-08-31 | 2021-07-15 | 오르카 테라퓨틱스 비.브이. | 글리코겐 합성효소 키나아제-3(gsk3)에 대한 코딩 영역을 포함하는 재조합 복제 가능 바이러스 및 비정상 세포 사멸 방법 |
| US20210324415A1 (en) | 2018-10-09 | 2021-10-21 | Nikegen, Llc | Compositions and methods for preparing viral vectors |
-
2017
- 2017-02-23 KR KR1020227040992A patent/KR20220163505A/ko not_active Ceased
- 2017-02-23 KR KR1020187026673A patent/KR20180112024A/ko not_active Abandoned
- 2017-02-23 CN CN202310696656.0A patent/CN117384961A/zh active Pending
- 2017-02-23 EP EP22194706.2A patent/EP4155411A1/en active Pending
- 2017-02-23 EP EP17711815.5A patent/EP3390645B1/en active Active
- 2017-02-23 WO PCT/US2017/019086 patent/WO2017147269A1/en not_active Ceased
- 2017-02-23 CA CA3013639A patent/CA3013639A1/en active Pending
- 2017-02-23 CN CN201780013061.3A patent/CN108699566B/zh active Active
- 2017-02-23 ES ES17711815T patent/ES2933174T3/es active Active
- 2017-02-23 JP JP2018544177A patent/JP7015551B2/ja active Active
- 2017-02-23 KR KR1020217016040A patent/KR102471633B1/ko active Active
- 2017-02-23 AU AU2017223589A patent/AU2017223589B2/en active Active
-
2018
- 2018-08-23 US US16/110,207 patent/US10738325B2/en active Active
-
2020
- 2020-06-30 US US16/916,764 patent/US11401529B2/en active Active
-
2022
- 2022-01-17 JP JP2022004999A patent/JP7534798B2/ja active Active
- 2022-06-29 US US17/852,891 patent/US12281324B2/en active Active
-
2023
- 2023-10-30 AU AU2023255054A patent/AU2023255054A1/en active Pending
-
2024
- 2024-07-26 JP JP2024121060A patent/JP2024156764A/ja active Pending
-
2025
- 2025-04-01 US US19/097,089 patent/US20250382638A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP7015551B2 (ja) | 2022-02-15 |
| US11401529B2 (en) | 2022-08-02 |
| US10738325B2 (en) | 2020-08-11 |
| KR20210065205A (ko) | 2021-06-03 |
| JP7534798B2 (ja) | 2024-08-15 |
| EP3390645B1 (en) | 2022-09-14 |
| EP3390645A1 (en) | 2018-10-24 |
| US20200325492A1 (en) | 2020-10-15 |
| WO2017147269A1 (en) | 2017-08-31 |
| CN117384961A (zh) | 2024-01-12 |
| AU2017223589A1 (en) | 2018-08-09 |
| ES2933174T3 (es) | 2023-02-02 |
| US20180355379A1 (en) | 2018-12-13 |
| CA3013639A1 (en) | 2017-08-31 |
| US12281324B2 (en) | 2025-04-22 |
| AU2023255054A1 (en) | 2023-11-16 |
| JP2022051769A (ja) | 2022-04-01 |
| EP4155411A1 (en) | 2023-03-29 |
| KR20180112024A (ko) | 2018-10-11 |
| CN108699566B (zh) | 2023-06-30 |
| AU2017223589B2 (en) | 2023-08-03 |
| US20230088476A1 (en) | 2023-03-23 |
| JP2024156764A (ja) | 2024-11-06 |
| CN108699566A (zh) | 2018-10-23 |
| US20250382638A1 (en) | 2025-12-18 |
| KR102471633B1 (ko) | 2022-11-25 |
| JP2019509037A (ja) | 2019-04-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US12281324B2 (en) | Exogenous gene expression in recombinant adenovirus for minimal impact on viral kinetics | |
| US12365878B2 (en) | Oncolytic adenovirus with enhanced replication properties comprising modifications in E1A, E3, and E4 | |
| JP7048494B2 (ja) | 修飾t細胞に対する条件的活性型キメラ抗原受容体 | |
| JP2025078752A (ja) | 腫瘍を標的にする合成アデノウイルスおよびその使用 | |
| CN114867491B (zh) | 用于肿瘤内和/或静脉内施用以治疗癌症的重组mva病毒 | |
| JP2021536256A (ja) | 修飾t細胞に対する条件的活性型キメラ抗原受容体 | |
| US20230220355A1 (en) | Recombinant adenovirus genome having a synthetic transcriptional unit and two step transcriptional regulation and amplification | |
| US20230218690A1 (en) | Oncolytic adenovirus with replication selectivity based on status of p53 transcriptional activity | |
| CN115477705A (zh) | 一种基于颗粒酶b构建的嵌合抗原受体免疫细胞制备及其应用 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A107 | Divisional application of patent | ||
| PA0104 | Divisional application for international application |
St.27 status event code: A-0-1-A10-A18-div-PA0104 St.27 status event code: A-0-1-A10-A16-div-PA0104 |
|
| PG1501 | Laying open of application |
St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| PA0201 | Request for examination |
St.27 status event code: A-1-2-D10-D11-exm-PA0201 |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
St.27 status event code: A-1-2-D10-D21-exm-PE0902 |
|
| T11-X000 | Administrative time limit extension requested |
St.27 status event code: U-3-3-T10-T11-oth-X000 |
|
| T11-X000 | Administrative time limit extension requested |
St.27 status event code: U-3-3-T10-T11-oth-X000 |
|
| E13-X000 | Pre-grant limitation requested |
St.27 status event code: A-2-3-E10-E13-lim-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
St.27 status event code: A-1-2-D10-D21-exm-PE0902 |
|
| T11-X000 | Administrative time limit extension requested |
St.27 status event code: U-3-3-T10-T11-oth-X000 |
|
| T11-X000 | Administrative time limit extension requested |
St.27 status event code: U-3-3-T10-T11-oth-X000 |
|
| T11-X000 | Administrative time limit extension requested |
St.27 status event code: U-3-3-T10-T11-oth-X000 |
|
| T13-X000 | Administrative time limit extension granted |
St.27 status event code: U-3-3-T10-T13-oth-X000 |
|
| E13-X000 | Pre-grant limitation requested |
St.27 status event code: A-2-3-E10-E13-lim-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| B15 | Application refused following examination |
Free format text: ST27 STATUS EVENT CODE: N-2-6-B10-B15-EXM-PE0601 (AS PROVIDED BY THE NATIONAL OFFICE) |
|
| PE0601 | Decision on rejection of patent |
St.27 status event code: N-2-6-B10-B15-exm-PE0601 |
|
| T11-X000 | Administrative time limit extension requested |
St.27 status event code: U-3-3-T10-T11-oth-X000 |