KR20220071193A - Kras g12d 억제제 - Google Patents

Kras g12d 억제제 Download PDF

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Publication number
KR20220071193A
KR20220071193A KR1020227009947A KR20227009947A KR20220071193A KR 20220071193 A KR20220071193 A KR 20220071193A KR 1020227009947 A KR1020227009947 A KR 1020227009947A KR 20227009947 A KR20227009947 A KR 20227009947A KR 20220071193 A KR20220071193 A KR 20220071193A
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South Korea
Prior art keywords
mmol
compound
alkyl
salt
mixture
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Korean (ko)
Inventor
시아오룬 왕
아론 크레이그 번스
제임스 게일 크리스텐슨
존 마이클 켓참
존 데이비드 로슨
매튜 아놀드 막스
크리스토퍼 로날드 스미스
쉘리 알렌
제임스 프란시스 블레이크
마크 조셉 치카렐리
조슈아 리안 달케
동후아 다이
제이 브래드포드 펠
존 피터 피셔
마케도니오 제이. 메히아
브래드 뉴하우스
퐁 응우옌
제이콥 매튜 오'리어리
스펜서 파크
마르타 이. 로드리게즈
파벨 세이브첸코브
토니 피. 탕
가이 피. 에이. 바이거스
첸 자오
딘 러셀 칸
존 가우디노
마이클 크리스토퍼 힐튼
Original Assignee
미라티 테라퓨틱스, 인크.
어레이 바이오파마 인크.
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Application filed by 미라티 테라퓨틱스, 인크., 어레이 바이오파마 인크. filed Critical 미라티 테라퓨틱스, 인크.
Publication of KR20220071193A publication Critical patent/KR20220071193A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020227009947A 2019-08-29 2020-08-27 Kras g12d 억제제 Pending KR20220071193A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962893604P 2019-08-29 2019-08-29
US62/893,604 2019-08-29
US202063052840P 2020-07-16 2020-07-16
US63/052,840 2020-07-16
US202063058188P 2020-07-29 2020-07-29
US63/058,188 2020-07-29
PCT/US2020/048194 WO2021041671A1 (en) 2019-08-29 2020-08-27 Kras g12d inhibitors

Publications (1)

Publication Number Publication Date
KR20220071193A true KR20220071193A (ko) 2022-05-31

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Family Applications (1)

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KR1020227009947A Pending KR20220071193A (ko) 2019-08-29 2020-08-27 Kras g12d 억제제

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US (3) US11453683B1 (enExample)
EP (1) EP4021444A4 (enExample)
JP (2) JP7622043B2 (enExample)
KR (1) KR20220071193A (enExample)
CN (1) CN114615981B (enExample)
AU (1) AU2020337938B2 (enExample)
BR (1) BR112022003543A2 (enExample)
CA (1) CA3148745A1 (enExample)
CL (1) CL2022000447A1 (enExample)
CO (1) CO2022003782A2 (enExample)
IL (1) IL290845A (enExample)
MX (1) MX2022002465A (enExample)
PH (1) PH12022550469A1 (enExample)
TW (2) TWI874443B (enExample)
WO (1) WO2021041671A1 (enExample)
ZA (1) ZA202202362B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024158242A1 (ko) * 2023-01-25 2024-08-02 주식회사 엔바이오스 Kras g12d 돌연변이 억제용 화합물 및 이를 유효성분으로 포함하는 암질환 예방 또는 치료용 조성물
WO2025143518A1 (ko) * 2023-12-26 2025-07-03 주식회사 베노바이오 Kras g12d 변이가 존재하는 암 치료를 위한 신규한 화합물 및 이를 이용한 암의 예방 또는 치료용 조성물

Families Citing this family (227)

* Cited by examiner, † Cited by third party
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WO2025143518A1 (ko) * 2023-12-26 2025-07-03 주식회사 베노바이오 Kras g12d 변이가 존재하는 암 치료를 위한 신규한 화합물 및 이를 이용한 암의 예방 또는 치료용 조성물

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