KR102688024B1 - Shp2의 활성을 억제하기 위한 n-아자스피로시클로알칸 치환된 n-헤테로아릴 화합물 및 조성물 - Google Patents

Shp2의 활성을 억제하기 위한 n-아자스피로시클로알칸 치환된 n-헤테로아릴 화합물 및 조성물 Download PDF

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KR102688024B1
KR102688024B1 KR1020237005361A KR20237005361A KR102688024B1 KR 102688024 B1 KR102688024 B1 KR 102688024B1 KR 1020237005361 A KR1020237005361 A KR 1020237005361A KR 20237005361 A KR20237005361 A KR 20237005361A KR 102688024 B1 KR102688024 B1 KR 102688024B1
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mmol
azaspiro
amino
tert
butyl
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KR20230028581A (ko
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크리스틴 히우-퉁 첸
주오리앙 첸
마이클 도레
호지 가르시아 포타네트
라제쉬 카르키
미츠노리 카토
매튜 제이. 라마르쉬
로렌스 블라스 페레즈
트로이 더글라스 스미스
사라 윌리엄스
존 윌리엄 기랄데스
배커리-배리 투레
마틴 센드지크
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노파르티스 아게
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    • C07D498/10—Spiro-condensed systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
KR1020237005361A 2014-01-17 2015-01-16 Shp2의 활성을 억제하기 위한 n-아자스피로시클로알칸 치환된 n-헤테로아릴 화합물 및 조성물 Active KR102688024B1 (ko)

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US201461928754P 2014-01-17 2014-01-17
US61/928,754 2014-01-17
US201461991129P 2014-05-09 2014-05-09
US61/991,129 2014-05-09
PCT/IB2015/050345 WO2015107495A1 (en) 2014-01-17 2015-01-16 N-azaspirocycloalkane substituted n-heteroaryl compounds and compositions for inhibiting the activity of shp2
KR1020167021977A KR102501558B1 (ko) 2014-01-17 2015-01-16 Shp2의 활성을 억제하기 위한 n-아자스피로시클로알칸 치환된 n-헤테로아릴 화합물 및 조성물

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KR102688024B1 true KR102688024B1 (ko) 2024-07-25

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KR1020167021977A Active KR102501558B1 (ko) 2014-01-17 2015-01-16 Shp2의 활성을 억제하기 위한 n-아자스피로시클로알칸 치환된 n-헤테로아릴 화합물 및 조성물

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