JPS58201994A - 抗原特異的ヒト免疫グロブリンの生産方法 - Google Patents
抗原特異的ヒト免疫グロブリンの生産方法Info
- Publication number
- JPS58201994A JPS58201994A JP57084843A JP8484382A JPS58201994A JP S58201994 A JPS58201994 A JP S58201994A JP 57084843 A JP57084843 A JP 57084843A JP 8484382 A JP8484382 A JP 8484382A JP S58201994 A JPS58201994 A JP S58201994A
- Authority
- JP
- Japan
- Prior art keywords
- human
- cells
- cell
- immunoglobulin
- fused
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Optics & Photonics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (31)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57084843A JPS58201994A (ja) | 1982-05-21 | 1982-05-21 | 抗原特異的ヒト免疫グロブリンの生産方法 |
| CA000428517A CA1247538A (en) | 1982-05-21 | 1983-05-19 | Human-human hybridomas for solid tumors |
| CS833566A CZ280677B6 (cs) | 1982-05-21 | 1983-05-19 | Lidské monoklonální protilátky a způsob jejich výroby |
| SK3566-83A SK356683A3 (en) | 1982-05-21 | 1983-05-19 | Human monoclonal antibodies and process for producing the same |
| PH28943A PH23031A (en) | 1982-05-21 | 1983-05-20 | Human-human hybridomas for cervical carcinoma |
| ES522585A ES8502547A1 (es) | 1982-05-21 | 1983-05-20 | Un metodo para determinar la presencia de una neoplasia. |
| HU832697A HU190908B (en) | 1982-05-21 | 1983-05-20 | Process for preparing humane-humane hybridomes and - by means thereof - monoclonal antibodies |
| EP83902157A EP0109441B1 (en) | 1982-05-21 | 1983-05-20 | Human-human hybridomas for neoplasms |
| PCT/US1983/000781 WO1983004313A1 (en) | 1982-05-21 | 1983-05-20 | Human-human hybridomas for neoplasms |
| JP58502264A JPS60501359A (ja) | 1982-05-21 | 1983-05-20 | 新生物用ヒト↓−ヒトハイブリド−マ |
| AT83902157T ATE114189T1 (de) | 1982-05-21 | 1983-05-20 | Humane-humane hybridomas für neoplasmen. |
| AU17729/83A AU560595B2 (en) | 1982-05-21 | 1983-05-20 | Human-human hybridomas for neoplasms |
| IT21217/83A IT1203702B (it) | 1982-05-21 | 1983-05-20 | Ibridomi uomo-uomo per carcinomi cervicali |
| DE3382764T DE3382764T2 (de) | 1982-05-21 | 1983-05-20 | Humane-humane hybridomas für neoplasmen. |
| KR1019830002232A KR880001567B1 (ko) | 1982-05-21 | 1983-05-21 | 경부암을 위한 인체-인체융합세포 |
| IL68752A IL68752A (en) | 1982-05-21 | 1983-05-22 | Human hybridomas cell lines producing monoclonal antibodies capable of distinguishing neoplastic cells from normal cells,antibodies produced by them and method for determining the presence of a neoplasm by using said antibodies |
| NZ204327A NZ204327A (en) | 1982-05-21 | 1983-05-23 | Human monoclonal antibodies against human neoplastic cells;human hybridomas producing such antibodies;diagnostic procedures |
| ZA833686A ZA833686B (en) | 1982-05-21 | 1983-05-23 | Human human hybridomas for cervical carcinoma |
| IT8348350A IT8348350A0 (it) | 1982-05-21 | 1983-05-23 | Ibridoma uomo-uomo per carcinoma cervicale |
| IN683/CAL/83A IN157982B (ref) | 1982-05-21 | 1983-05-31 | |
| ES528897A ES8504463A1 (es) | 1982-05-21 | 1984-01-16 | Un metodo para la preparacion de anticuerpos monoclonales humanos especificos para las celulas neoplasicas |
| FI840219A FI86077C (fi) | 1982-05-21 | 1984-01-19 | Monoklonala antikroppar och metod att producera dessa. |
| DK025084A DK164510C (da) | 1982-05-21 | 1984-01-20 | Humant hybridom, humant monoklonalt antistof opnaaet derfra, anvendelse af et saadant antistof og fremgangsmaade til fremstilling af et saadant antistof |
| NO840215A NO165510C (no) | 1982-05-21 | 1984-01-20 | Monoklonale antistoffer, samt anvendelse av dem in vitro for bestemmelse av naervaer av neoplasmer. |
| PH32453A PH21344A (en) | 1982-05-21 | 1985-06-25 | Human-human hybridomas for cervical carcinoma |
| US07/113,212 US5286647A (en) | 1982-05-21 | 1987-10-23 | Human-human hybridomas for neoplasms |
| JP5168343A JPH07121221B2 (ja) | 1982-05-21 | 1993-06-16 | 抗原特異的ヒト免疫グロブリン生産性ヒト／ヒトハイブリドーマ |
| JP5168345A JPH07119240B2 (ja) | 1982-05-21 | 1993-06-16 | 抗原特異的ヒト免疫グロブリン |
| US08/443,810 US6051229A (en) | 1982-05-21 | 1995-05-18 | Human-human hybridom for neoplasms CLNH5 and CLNH11 specific antibody compositions |
| US08/482,197 US6051693A (en) | 1982-05-21 | 1995-06-07 | CLNH11-specific antibodies |
| US08/480,014 US6051387A (en) | 1982-05-21 | 1995-06-07 | Methods of determining the presence of a neoplasm with CLNH5- and CLNH11-specific antibodies |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57084843A JPS58201994A (ja) | 1982-05-21 | 1982-05-21 | 抗原特異的ヒト免疫グロブリンの生産方法 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5168345A Division JPH07119240B2 (ja) | 1982-05-21 | 1993-06-16 | 抗原特異的ヒト免疫グロブリン |
| JP5168343A Division JPH07121221B2 (ja) | 1982-05-21 | 1993-06-16 | 抗原特異的ヒト免疫グロブリン生産性ヒト／ヒトハイブリドーマ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS58201994A true JPS58201994A (ja) | 1983-11-25 |
| JPH0159878B2 JPH0159878B2 (ref) | 1989-12-20 |
Family
ID=13842073
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57084843A Granted JPS58201994A (ja) | 1982-05-21 | 1982-05-21 | 抗原特異的ヒト免疫グロブリンの生産方法 |
| JP58502264A Pending JPS60501359A (ja) | 1982-05-21 | 1983-05-20 | 新生物用ヒト↓−ヒトハイブリド−マ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58502264A Pending JPS60501359A (ja) | 1982-05-21 | 1983-05-20 | 新生物用ヒト↓−ヒトハイブリド−マ |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0109441B1 (ref) |
| JP (2) | JPS58201994A (ref) |
| AT (1) | ATE114189T1 (ref) |
| AU (1) | AU560595B2 (ref) |
| CZ (1) | CZ280677B6 (ref) |
| DE (1) | DE3382764T2 (ref) |
| DK (1) | DK164510C (ref) |
| FI (1) | FI86077C (ref) |
| HU (1) | HU190908B (ref) |
| IN (1) | IN157982B (ref) |
| SK (1) | SK356683A3 (ref) |
| WO (1) | WO1983004313A1 (ref) |
| ZA (1) | ZA833686B (ref) |
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| JPS6024184A (ja) * | 1983-03-09 | 1985-02-06 | スロ−ン−ケツタリング・インステイテユ−ト・フオ−・キヤンサ−・リサ−チ | ガン細胞に対するヒトのモノクロ−ン抗体の反応 |
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| JPS61204134A (ja) * | 1984-10-15 | 1986-09-10 | ザ・リ−ジエンツ・オブ・ザ・ユニバ−シテイ−・オブ・カリフオルニア | 癌細胞に対する抗体を産生するヒト−ヒトハイブリド−マ細胞系 |
| JPS6299332A (ja) * | 1985-10-26 | 1987-05-08 | Hagiwara Yoshihide | 悪性腫瘍用ヒトモノクロナル抗体複合剤 |
| JPS62163686A (ja) * | 1986-01-13 | 1987-07-20 | Mitsubishi Chem Ind Ltd | 抗体産生細胞株の樹立方法 |
| WO1992020799A1 (fr) * | 1991-05-22 | 1992-11-26 | Hagiwara, Yoshihide | Sequence d'acides amines d'anticorps monoclonal humain anticancer et sequence de bases d'adn codant pour ces acides amines |
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| US20240092890A1 (en) | 2020-08-27 | 2024-03-21 | Juntendo Educational Foundation | Anti-cleaved mutant calr-cd3 bispecific antibody and pharmaceutical composition |
| MX2023010491A (es) | 2021-03-12 | 2023-09-18 | Chugai Pharmaceutical Co Ltd | Composicion farmaceutica para el tratamiento o la prevencion de la miastenia gravis. |
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| KR20240011866A (ko) | 2021-12-01 | 2024-01-26 | 추가이 세이야쿠 가부시키가이샤 | 항체 함유 제제의 조제 방법 |
| EP4483899A1 (en) | 2022-02-25 | 2025-01-01 | Juntendo Educational Foundation | Medicine comprising combination of anti-mutant-calr antibody and another drug |
| WO2025198912A1 (en) | 2024-03-21 | 2025-09-25 | Hoffmann-La Roche Inc. | Methods of treating myasthenia gravis |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57502090A (ref) * | 1980-07-18 | 1982-11-25 | ||
| NZ198851A (en) * | 1980-11-07 | 1984-07-31 | Wistar Inst | Stable,continuous human myeloma cell line capable of hybridisation with antibody-producing cells:production of hybrid cell line |
-
1982
- 1982-05-21 JP JP57084843A patent/JPS58201994A/ja active Granted
-
1983
- 1983-05-19 CZ CS833566A patent/CZ280677B6/cs not_active IP Right Cessation
- 1983-05-19 SK SK3566-83A patent/SK356683A3/sk unknown
- 1983-05-20 EP EP83902157A patent/EP0109441B1/en not_active Expired - Lifetime
- 1983-05-20 JP JP58502264A patent/JPS60501359A/ja active Pending
- 1983-05-20 AT AT83902157T patent/ATE114189T1/de not_active IP Right Cessation
- 1983-05-20 HU HU832697A patent/HU190908B/hu not_active IP Right Cessation
- 1983-05-20 WO PCT/US1983/000781 patent/WO1983004313A1/en not_active Ceased
- 1983-05-20 AU AU17729/83A patent/AU560595B2/en not_active Expired
- 1983-05-20 DE DE3382764T patent/DE3382764T2/de not_active Expired - Lifetime
- 1983-05-23 ZA ZA833686A patent/ZA833686B/xx unknown
- 1983-05-31 IN IN683/CAL/83A patent/IN157982B/en unknown
-
1984
- 1984-01-19 FI FI840219A patent/FI86077C/fi not_active IP Right Cessation
- 1984-01-20 DK DK025084A patent/DK164510C/da not_active IP Right Cessation
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6024184A (ja) * | 1983-03-09 | 1985-02-06 | スロ−ン−ケツタリング・インステイテユ−ト・フオ−・キヤンサ−・リサ−チ | ガン細胞に対するヒトのモノクロ−ン抗体の反応 |
| JPS6012973A (ja) * | 1983-03-11 | 1985-01-23 | スロ−ン−ケツタリング・インステイテユ−ト・フオ−・キヤンサ−・リサ−チ | 悪性黒色腫のある患者のリンパ球からのヒトの単一クロ−ン抗体 |
| JPS60260597A (ja) * | 1984-01-31 | 1985-12-23 | アクゾ ナムローゼ フェンノートシャップ | 自己由来のワクチン |
| JPS6133125A (ja) * | 1984-07-25 | 1986-02-17 | Morinaga & Co Ltd | ヒト単クロ−ン性抗肺ガン細胞抗体 |
| JPS61204134A (ja) * | 1984-10-15 | 1986-09-10 | ザ・リ−ジエンツ・オブ・ザ・ユニバ−シテイ−・オブ・カリフオルニア | 癌細胞に対する抗体を産生するヒト−ヒトハイブリド−マ細胞系 |
| JPS61130300A (ja) * | 1984-11-27 | 1986-06-18 | ザ ボ−ド オブ トラステイ−ズ オブ ザ レランド スタンフオ−ド ジユニア ユニバ−シテイ | ヒトモノクロ−ナル抗体 |
| JPS6299332A (ja) * | 1985-10-26 | 1987-05-08 | Hagiwara Yoshihide | 悪性腫瘍用ヒトモノクロナル抗体複合剤 |
| JPS62163686A (ja) * | 1986-01-13 | 1987-07-20 | Mitsubishi Chem Ind Ltd | 抗体産生細胞株の樹立方法 |
| WO1992020799A1 (fr) * | 1991-05-22 | 1992-11-26 | Hagiwara, Yoshihide | Sequence d'acides amines d'anticorps monoclonal humain anticancer et sequence de bases d'adn codant pour ces acides amines |
Also Published As
| Publication number | Publication date |
|---|---|
| DE3382764T2 (de) | 1995-03-16 |
| CZ356683A3 (en) | 1995-11-15 |
| SK279249B6 (sk) | 1998-08-05 |
| DK164510B (da) | 1992-07-06 |
| SK356683A3 (en) | 1998-08-05 |
| ZA833686B (en) | 1984-09-26 |
| FI86077B (fi) | 1992-03-31 |
| EP0109441A1 (en) | 1984-05-30 |
| AU1772983A (en) | 1983-12-16 |
| FI840219A0 (fi) | 1984-01-19 |
| ATE114189T1 (de) | 1994-12-15 |
| FI840219L (fi) | 1984-01-19 |
| FI86077C (fi) | 1992-07-10 |
| DK25084D0 (da) | 1984-01-20 |
| EP0109441B1 (en) | 1994-11-17 |
| CZ280677B6 (cs) | 1996-04-17 |
| DK25084A (da) | 1984-01-20 |
| DK164510C (da) | 1992-11-23 |
| IN157982B (ref) | 1986-08-09 |
| WO1983004313A1 (en) | 1983-12-08 |
| EP0109441A4 (en) | 1986-09-22 |
| HU190908B (en) | 1986-12-28 |
| AU560595B2 (en) | 1987-04-09 |
| DE3382764D1 (de) | 1994-12-22 |
| JPS60501359A (ja) | 1985-08-22 |
| JPH0159878B2 (ref) | 1989-12-20 |
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