JP7408396B2 - 併用療法 - Google Patents

併用療法 Download PDF

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Publication number
JP7408396B2
JP7408396B2 JP2019556986A JP2019556986A JP7408396B2 JP 7408396 B2 JP7408396 B2 JP 7408396B2 JP 2019556986 A JP2019556986 A JP 2019556986A JP 2019556986 A JP2019556986 A JP 2019556986A JP 7408396 B2 JP7408396 B2 JP 7408396B2
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axl
cancer
cells
antibody
adc
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Japanese (ja)
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JP2020517652A5 (enExample
JP2020517652A (ja
Inventor
ベルケル，パトリシウス ヘンドリクス コルネリス ファン
ヴァートナー，イェンス
ハートリー，ジョン
ザンマールキ，フランチェスカ
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MedImmune Ltd
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MedImmune Ltd
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Priority claimed from GBGB1706231.6A external-priority patent/GB201706231D0/en
Priority claimed from GBGB1706226.6A external-priority patent/GB201706226D0/en
Priority claimed from GBGB1706225.8A external-priority patent/GB201706225D0/en
Priority claimed from GBGB1706228.2A external-priority patent/GB201706228D0/en
Priority claimed from GBGB1706223.3A external-priority patent/GB201706223D0/en
Priority claimed from GBGB1706224.1A external-priority patent/GB201706224D0/en
Priority claimed from GBGB1706227.4A external-priority patent/GB201706227D0/en
Priority claimed from GBGB1706230.8A external-priority patent/GB201706230D0/en
Priority claimed from GBGB1706229.0A external-priority patent/GB201706229D0/en
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Publication of JP2020517652A5 publication Critical patent/JP2020517652A5/ja
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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