CA3057748A1 - Combination therapy with an anti-axl antibody-drug conjugate - Google Patents

Combination therapy with an anti-axl antibody-drug conjugate Download PDF

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Publication number
CA3057748A1
CA3057748A1 CA3057748A CA3057748A CA3057748A1 CA 3057748 A1 CA3057748 A1 CA 3057748A1 CA 3057748 A CA3057748 A CA 3057748A CA 3057748 A CA3057748 A CA 3057748A CA 3057748 A1 CA3057748 A1 CA 3057748A1
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CA
Canada
Prior art keywords
composition
cancer
kit according
axl
individual
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3057748A
Other languages
English (en)
French (fr)
Inventor
Patricius Hendrikus Cornelis VAN BERKEL
Jens WUERTHNER
John Hartley
Francesca ZAMMARCHI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADC Therapeutics SA
MedImmune Ltd
Original Assignee
ADC Therapeutics SA
MedImmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1706225.8A external-priority patent/GB201706225D0/en
Priority claimed from GBGB1706230.8A external-priority patent/GB201706230D0/en
Priority claimed from GBGB1706223.3A external-priority patent/GB201706223D0/en
Priority claimed from GBGB1706229.0A external-priority patent/GB201706229D0/en
Priority claimed from GBGB1706228.2A external-priority patent/GB201706228D0/en
Priority claimed from GBGB1706227.4A external-priority patent/GB201706227D0/en
Priority claimed from GBGB1706224.1A external-priority patent/GB201706224D0/en
Priority claimed from GBGB1706226.6A external-priority patent/GB201706226D0/en
Priority claimed from GBGB1706231.6A external-priority patent/GB201706231D0/en
Application filed by ADC Therapeutics SA, MedImmune Ltd filed Critical ADC Therapeutics SA
Publication of CA3057748A1 publication Critical patent/CA3057748A1/en
Pending legal-status Critical Current

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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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GBGB1706228.2A GB201706228D0 (en) 2017-04-20 2017-04-20 Combination therapy
GB1706227.4 2017-04-20
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GB1706231.6 2017-04-20
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GBGB1706227.4A GB201706227D0 (en) 2017-04-20 2017-04-20 Combination therapy
GBGB1706224.1A GB201706224D0 (en) 2017-04-20 2017-04-20 Combination therapy
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GBGB1706231.6A GB201706231D0 (en) 2017-04-20 2017-04-20 Combination therapy
GB1706225.8 2017-04-20
GB1706223.3 2017-04-20
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