AU2018253948B2 - Combination therapy with an anti-AXL Antibody-Drug Conjugate - Google Patents

Combination therapy with an anti-AXL Antibody-Drug Conjugate Download PDF

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Publication number
AU2018253948B2
AU2018253948B2 AU2018253948A AU2018253948A AU2018253948B2 AU 2018253948 B2 AU2018253948 B2 AU 2018253948B2 AU 2018253948 A AU2018253948 A AU 2018253948A AU 2018253948 A AU2018253948 A AU 2018253948A AU 2018253948 B2 AU2018253948 B2 AU 2018253948B2
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Australia
Prior art keywords
alkyl
group
axl
cancer
phenyl
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AU2018253948A
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AU2018253948A1 (en
Inventor
John Hartley
Patricius Hendrikus Cornelis VAN BERKEL
Jens WUERTHNER
Francesca ZAMMARCHI
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ADC Therapeutics SA
MedImmune Ltd
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ADC Therapeutics SA
MedImmune Ltd
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Priority claimed from GBGB1706227.4A external-priority patent/GB201706227D0/en
Priority claimed from GBGB1706224.1A external-priority patent/GB201706224D0/en
Priority claimed from GBGB1706231.6A external-priority patent/GB201706231D0/en
Priority claimed from GBGB1706226.6A external-priority patent/GB201706226D0/en
Priority claimed from GBGB1706225.8A external-priority patent/GB201706225D0/en
Priority claimed from GBGB1706230.8A external-priority patent/GB201706230D0/en
Priority claimed from GBGB1706229.0A external-priority patent/GB201706229D0/en
Priority claimed from GBGB1706228.2A external-priority patent/GB201706228D0/en
Priority claimed from GBGB1706223.3A external-priority patent/GB201706223D0/en
Application filed by ADC Therapeutics SA, MedImmune Ltd filed Critical ADC Therapeutics SA
Publication of AU2018253948A1 publication Critical patent/AU2018253948A1/en
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K2039/507—Comprising a combination of two or more separate antibodies
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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