JP7216006B2 - ヒドロゲル架橋ヒアルロン酸プロドラッグ組成物及び方法 - Google Patents

ヒドロゲル架橋ヒアルロン酸プロドラッグ組成物及び方法 Download PDF

Info

Publication number
JP7216006B2
JP7216006B2 JP2019552587A JP2019552587A JP7216006B2 JP 7216006 B2 JP7216006 B2 JP 7216006B2 JP 2019552587 A JP2019552587 A JP 2019552587A JP 2019552587 A JP2019552587 A JP 2019552587A JP 7216006 B2 JP7216006 B2 JP 7216006B2
Authority
JP
Japan
Prior art keywords
antibody
seq
amino acid
acid sequence
vegf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2019552587A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020515545A5 (cg-RX-API-DMAC10.html
JP2020515545A (ja
Inventor
ゼバスティアン シュタルク，
トーマス クナッペ，
ハーラルト ラウ，
ニコラ ビセク，
ブルックハルト ラウファー，
ザームエル ワイスブロット，
トビアス フォークト，
ジャーメイン フー，
パトリック ケーニグ，
チンウェイ ヴィヴィアン リー，
ダニエラ バンバカ ヤーダブ，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of JP2020515545A publication Critical patent/JP2020515545A/ja
Publication of JP2020515545A5 publication Critical patent/JP2020515545A5/ja
Priority to JP2023005856A priority Critical patent/JP2023058511A/ja
Application granted granted Critical
Publication of JP7216006B2 publication Critical patent/JP7216006B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6903—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being semi-solid, e.g. an ointment, a gel, a hydrogel or a solidifying gel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2019552587A 2017-03-22 2018-03-22 ヒドロゲル架橋ヒアルロン酸プロドラッグ組成物及び方法 Active JP7216006B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023005856A JP2023058511A (ja) 2017-03-22 2023-01-18 ヒドロゲル架橋ヒアルロン酸プロドラッグ組成物及び方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762475094P 2017-03-22 2017-03-22
US62/475,094 2017-03-22
PCT/US2018/023857 WO2018175788A1 (en) 2017-03-22 2018-03-22 Hydrogel cross-linked hyaluronic acid prodrug compositions and methods

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023005856A Division JP2023058511A (ja) 2017-03-22 2023-01-18 ヒドロゲル架橋ヒアルロン酸プロドラッグ組成物及び方法

Publications (3)

Publication Number Publication Date
JP2020515545A JP2020515545A (ja) 2020-05-28
JP2020515545A5 JP2020515545A5 (cg-RX-API-DMAC10.html) 2021-04-30
JP7216006B2 true JP7216006B2 (ja) 2023-01-31

Family

ID=61906882

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019552587A Active JP7216006B2 (ja) 2017-03-22 2018-03-22 ヒドロゲル架橋ヒアルロン酸プロドラッグ組成物及び方法
JP2023005856A Pending JP2023058511A (ja) 2017-03-22 2023-01-18 ヒドロゲル架橋ヒアルロン酸プロドラッグ組成物及び方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023005856A Pending JP2023058511A (ja) 2017-03-22 2023-01-18 ヒドロゲル架橋ヒアルロン酸プロドラッグ組成物及び方法

Country Status (13)

Country Link
US (3) US11642415B2 (cg-RX-API-DMAC10.html)
EP (1) EP3600441A1 (cg-RX-API-DMAC10.html)
JP (2) JP7216006B2 (cg-RX-API-DMAC10.html)
KR (2) KR102715397B1 (cg-RX-API-DMAC10.html)
CN (1) CN110891611B (cg-RX-API-DMAC10.html)
AR (1) AR111190A1 (cg-RX-API-DMAC10.html)
AU (1) AU2018240375C1 (cg-RX-API-DMAC10.html)
IL (1) IL269506B2 (cg-RX-API-DMAC10.html)
MA (1) MA49265A (cg-RX-API-DMAC10.html)
SG (2) SG10202107829YA (cg-RX-API-DMAC10.html)
TW (1) TWI857935B (cg-RX-API-DMAC10.html)
WO (1) WO2018175788A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA201905930B (cg-RX-API-DMAC10.html)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015200905A2 (en) 2014-06-28 2015-12-30 Oligasis, Llc Dual pdgf/vegf antagonists
IL290457B2 (en) 2015-12-30 2025-02-01 Kodiak Sciences Inc Antibodies and their conjugates
JP7216006B2 (ja) * 2017-03-22 2023-01-31 ジェネンテック， インコーポレイテッド ヒドロゲル架橋ヒアルロン酸プロドラッグ組成物及び方法
CA3092588A1 (en) 2018-03-02 2019-09-06 Kodiak Sciences Inc. Il-6 antibodies and fusion constructs and conjugates thereof
CA3093083A1 (en) 2018-03-28 2019-10-03 Ascendis Pharma A/S Conjugates
US12565525B2 (en) 2018-03-28 2026-03-03 Ascendis Pharma Oncology Division A/S IL-2 conjugates
CA3114272A1 (en) * 2018-09-26 2020-04-02 Ascendis Pharma A/S Degradable hyaluronic acid hydrogels
SG11202104966XA (en) 2019-01-04 2021-06-29 Ascendis Pharma Oncology Div A/S Sustained local drug levels for innate immune agonists
AU2020205029A1 (en) 2019-01-04 2021-06-24 Ascendis Pharma Oncology Division A/S Minimization of systemic inflammation
SG11202105835YA (en) 2019-01-04 2021-07-29 Ascendis Pharma Oncology Div A/S Conjugates of pattern recognition receptor agonists
EP3906018A1 (en) 2019-01-04 2021-11-10 Ascendis Pharma Oncology Division A/S Induction of sustained local inflammation
PE20240329A1 (es) 2019-06-05 2024-02-27 Regeneron Pharma Dispositivos y metodos para administracion de dosis de precision
WO2020254612A1 (en) 2019-06-21 2020-12-24 Ascendis Pharma Oncology Division A/S Controlled-release tyrosine kinase inhibitor compounds with localized pd properties
WO2020254607A1 (en) 2019-06-21 2020-12-24 Ascendis Pharma Oncology Division A/S Anti-ctla4 compounds with localized pd properties
WO2020254617A1 (en) 2019-06-21 2020-12-24 Ascendis Pharma Oncology Division A/S Anti-ctla4 compounds with localized pk properties
TW202114738A (zh) 2019-06-21 2021-04-16 丹麥商阿仙帝斯製藥公司 抗ctla4結合物
WO2020254613A1 (en) 2019-06-21 2020-12-24 Ascendis Pharma Oncology Division A/S Controlled-release tyrosine kinase inhibitor compounds with localized pk properties
CA3143278A1 (en) 2019-06-21 2020-12-24 Ascendis Pharma Oncology Division A/S Tyrosine kinase inhibitor conjugates
CA3157509A1 (en) 2019-10-10 2021-04-15 Kodiak Sciences Inc. Methods of treating an eye disorder
CA3161098A1 (en) 2020-01-03 2021-07-08 Ascendis Pharma A/S Conjugates undergoing intramolecular rearrangements
WO2021224169A1 (en) 2020-05-04 2021-11-11 Ascendis Pharma A/S Hydrogel irradiation
CA3178074A1 (en) 2020-06-03 2021-12-09 Nina Gunnarsson Il-2 sequences and uses thereof
GB202011993D0 (en) 2020-07-31 2020-09-16 Adc Therapeutics Sa ANTI-IL 13Ra2 antibodies
AU2021335032A1 (en) 2020-08-28 2023-03-09 Ascendis Pharma Oncology Division A/S Glycosylated IL-2 proteins and uses thereof
EP4314035A1 (en) 2021-04-01 2024-02-07 Ascendis Pharma A/S Use of long-acting growth hormone for treating inflammation-induced diseases
WO2023001288A1 (zh) * 2021-07-23 2023-01-26 百奥泰生物制药股份有限公司 整合素GPIIb/IIIa拮抗剂及其和抗VEGF抗体联合用药的应用
US12649031B2 (en) 2021-09-08 2026-06-09 Regeneron Pharmaceuticals, Inc. Methods for delivering agents with pre-filled syringes to minimize intraocular inflammation
JP2024546134A (ja) 2021-12-13 2024-12-17 アセンディス ファーマ オンコロジー ディヴィジョン エー／エス Ｔｌｒ７／８アゴニストを用いたがん治療
TW202400244A (zh) * 2022-04-15 2024-01-01 美商瓦利托爾有限公司 經純化之多價蛋白質玻尿酸聚合物結合物
CN115389681B (zh) * 2022-11-01 2023-01-20 常州百瑞吉生物医药有限公司 一种巯基化透明质酸衍生物中二硫苏糖醇残留的检测方法
USD1120314S1 (en) 2022-11-30 2026-03-24 Regeneron Pharmaceuticals, Inc. Dose delivery device
TW202430223A (zh) 2023-01-05 2024-08-01 丹麥商阿仙帝斯眼科製藥有限公司 用於治療眼部病症之藥物結合物
TW202434299A (zh) 2023-01-05 2024-09-01 丹麥商阿仙帝斯製藥公司 製造水凝膠微球之方法
IL323019A (en) 2023-03-06 2025-10-01 Ascendis Pharma As Drug compounds with an albumin-binding moiety
WO2026002095A1 (en) * 2024-06-26 2026-01-02 Coval Biopharma (Shanghai) Co., Ltd. Drug delivery system for locally controlled release of therapeutic agents and uses thereof
WO2026112108A1 (en) * 2024-11-20 2026-05-28 Valitor, Inc. Multivalent protein conjugates

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100210509A1 (en) 2007-10-09 2010-08-19 Postech Academy-Industry Foundation Long acting hyaluronic acid - peptide conjugate
JP2013501781A (ja) 2009-08-11 2013-01-17 エージェンシー フォー サイエンス， テクノロジー アンド リサーチ 生体活性物質の細胞送達のための粒子状ヒアルロン酸製剤
US20140080897A1 (en) 2012-09-18 2014-03-20 Postech Academy-Industry Foundation Hyaluronic acid-nucleic acid conjugate and composition for nucleic acid delivery containing the same
US20140294752A1 (en) 2013-04-01 2014-10-02 Research & Business Foundation Sungkyunkwan University Method for nucleic acid delivery using hyaluronic acid
JP2014528465A (ja) 2011-10-12 2014-10-27 アセンディス ファーマ オフサルモロジー ディヴィジョン エー／エス 眼の状態の予防及び治療
US20160002366A1 (en) 2013-02-20 2016-01-07 The University Of Queensland Conjugate compound and uses of same
WO2016193371A1 (en) 2015-06-05 2016-12-08 Sanofi Prodrugs comprising an glp-1/glucagon dual agonist linker hyaluronic acid conjugate

Family Cites Families (229)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4716224A (en) 1984-05-04 1987-12-29 Seikagaku Kogyo Co. Ltd. Crosslinked hyaluronic acid and its use
US5128326A (en) 1984-12-06 1992-07-07 Biomatrix, Inc. Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
US4937270A (en) 1987-09-18 1990-06-26 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
EP0326111A3 (en) 1988-01-29 1989-12-27 New York Blood Center, Inc. Peptide derivatives rendered immunogenic when administered with alum as an adjuvant
IT1219587B (it) 1988-05-13 1990-05-18 Fidia Farmaceutici Polisaccaridi carbossiilici autoreticolati
FI903489A7 (fi) 1988-11-11 1990-07-10 Medical Res Council Yhden osan sisältävät ligandit, näitä ligandeja sisältävät reseptorit, menetelmiä niiden valmistamiseksi sekä ligandien ja reseptorien käytt ö
SE8900422D0 (sv) 1989-02-08 1989-02-08 Pharmacia Ab Tvaerbundna hyaluronatgeler samt foerfarande foer framstaellning av dessa
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US5356883A (en) 1989-08-01 1994-10-18 Research Foundation Of State University Of N.Y. Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use
US5959177A (en) 1989-10-27 1999-09-28 The Scripps Research Institute Transgenic plants expressing assembled secretory antibodies
JP3046623B2 (ja) 1990-06-14 2000-05-29 ヴィタフォア コーポレイション ポリウレタン―生体高分子複合体
ES2084825T3 (es) 1990-07-26 1996-05-16 Monsanto Co Procedimiento de preparacion de poliamidas entrecruzadas.
DE69129154T2 (de) 1990-12-03 1998-08-20 Genentech, Inc., South San Francisco, Calif. Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
US5144088A (en) 1991-04-26 1992-09-01 Aristech Chemical Corporation Manufacture of neopentyl glycol (I)
EP0590058B1 (en) 1991-06-14 2003-11-26 Genentech, Inc. HUMANIZED Heregulin ANTIBODy
GB9114948D0 (en) 1991-07-11 1991-08-28 Pfizer Ltd Process for preparing sertraline intermediates
EP0604580A1 (en) 1991-09-19 1994-07-06 Genentech, Inc. EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab') 2? ANTIBODIES
FI941572L (fi) 1991-10-07 1994-05-27 Oncologix Inc Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä
WO1993009176A2 (en) 1991-10-29 1993-05-13 Clover Consolidated, Limited Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
DE69233528T2 (de) 1991-11-25 2006-03-16 Enzon, Inc. Verfahren zur Herstellung von multivalenten antigenbindenden Proteinen
CA2372813A1 (en) 1992-02-06 1993-08-19 L.L. Houston Biosynthetic binding protein for cancer marker
US5514379A (en) 1992-08-07 1996-05-07 The General Hospital Corporation Hydrogel compositions and methods of use
GB9216925D0 (en) 1992-08-10 1992-09-23 Royal Holloway Microspheres of polyhydroxylic materials
JP3107488B2 (ja) 1993-09-29 2000-11-06 株式会社資生堂 架橋ヒアルロン酸を用いた徐放性製剤及び塞栓剤
US5658592A (en) 1994-05-13 1997-08-19 Kuraray Co., Ltd. Medical crosslinked polymer gel of carboxylic polysaccharide and diaminoalkane
US6063396A (en) 1994-10-26 2000-05-16 Houston Biotechnology Incorporated Methods and compositions for the modulation of cell proliferation and wound healing
US5789199A (en) 1994-11-03 1998-08-04 Genentech, Inc. Process for bacterial production of polypeptides
US5690961A (en) 1994-12-22 1997-11-25 Hercules Incorporated Acidic polysaccharides crosslinked with polycarboxylic acids and their uses
US5840523A (en) 1995-03-01 1998-11-24 Genetech, Inc. Methods and compositions for secretion of heterologous polypeptides
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
IT1281886B1 (it) 1995-05-22 1998-03-03 Fidia Advanced Biopolymers Srl Processo per la preparazione di idrogel ottenuti da derivati chimici dell'acido ialuronico mediante irradiazioni ultraviolette e loro
US5612321A (en) 1995-06-22 1997-03-18 Hercules Incorporated Antioxidant grafted polysaccharides
JP3130234B2 (ja) 1995-09-29 2001-01-31 デンセイ・ラムダ株式会社 インバータ装置
WO1997028828A1 (en) 1996-02-09 1997-08-14 Amgen Boulder Inc. Composition comprising interleukin-1 inhibitor and controlled release polymer
US6303585B1 (en) 1997-07-03 2001-10-16 Orquest, Inc. Cross-linked polysaccharide drug carrier
JPH1133104A (ja) 1997-07-16 1999-02-09 Res Inst For Prod Dev 生体組織への接着性を有する医用材料
US6040498A (en) 1998-08-11 2000-03-21 North Caroline State University Genetically engineered duckweed
WO1999029888A1 (en) 1997-12-05 1999-06-17 The Scripps Research Institute Humanization of murine antibody
US6624142B2 (en) 1997-12-30 2003-09-23 Enzon, Inc. Trimethyl lock based tetrapartate prodrugs
WO1999059603A1 (en) 1998-05-20 1999-11-25 Chugai Seiyaku Kabushiki Kaisha Remedies for joint diseases bound to hyaluronic acid
ITPD980169A1 (it) 1998-07-06 2000-01-06 Fidia Advanced Biopolymers Srl Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione.
US6630457B1 (en) 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
JP2000119196A (ja) 1998-10-07 2000-04-25 Menicon Co Ltd 眼科用薬剤徐放材及びその製造方法
IT1303735B1 (it) 1998-11-11 2001-02-23 Falorni Italia Farmaceutici S Acidi ialuronici reticolati e loro usi medici.
EP1137373A4 (en) 1998-12-04 2004-05-19 Chandrashekhar P Pathak BIOCOMPATIBLE, CROSSLINKED POLYMERS
CA2365767A1 (en) 1999-03-15 2000-09-21 Trustees Of Boston University Angiogenesis inhibition
KR100797667B1 (ko) 1999-10-04 2008-01-23 메디카고 인코포레이티드 외래 유전자의 전사를 조절하는 방법
US7125978B1 (en) 1999-10-04 2006-10-24 Medicago Inc. Promoter for regulating expression of foreign genes
WO2001040314A1 (en) 1999-11-26 2001-06-07 The Regents Of The University Of Michigan Reversible cross-linked hydrogels
JP2003516755A (ja) 1999-12-15 2003-05-20 ジェネンテック・インコーポレーテッド ショットガン走査、すなわち機能性タンパク質エピトープをマッピングするための組み合わせ方法
PT2857516T (pt) 2000-04-11 2017-08-28 Genentech Inc Anticorpos multivalentes e utilizações dos mesmos
ATE298256T1 (de) 2000-07-31 2005-07-15 Iscience Corp Biomaterial in form von mikropartikeln von hyaluronsaure zur medizinischen verwendung
IT1317358B1 (it) 2000-08-31 2003-06-16 Fidia Advanced Biopolymers Srl Derivati cross-linkati dell'acido ialuronico.
DK1355566T3 (da) 2000-12-18 2013-03-04 Univ Texas Lokal regional kemoterapi og radioterapi ved anvendelse af hydrogel in situ
WO2002068383A2 (en) 2001-02-22 2002-09-06 Anika Therapeutics, Inc. Thiol-modified hyaluronan
ITMI20011238A1 (it) 2001-06-12 2002-12-12 Bartholdy Consultadoria E Serv Polimeri polisaccaridici di origine naturale coniugati chimicamente asostanze farmacologicamente o biologicamente attive e loro proprieta'
ITPD20020064A1 (it) 2002-03-12 2003-09-12 Fidia Advanced Biopolymers Srl Derivati esterei dell'acido ialuronico per la preparazione di idrogelda utilizzare in campo biomedico, sanitario e chirurgico e come sistem
US7056901B2 (en) 2002-03-29 2006-06-06 The Regents Of The University Of California Microgel particles for the delivery of bioactive materials
AU2003221078A1 (en) 2002-04-08 2003-10-20 Denki Kagaku Kogyo Kabushiki Kaisha Therapeutic composition for bone infectious disease
US7375234B2 (en) 2002-05-30 2008-05-20 The Scripps Research Institute Copper-catalysed ligation of azides and acetylenes
EP1513879B1 (en) 2002-06-03 2018-08-22 Genentech, Inc. Synthetic antibody phage libraries
KR100507545B1 (ko) 2002-09-03 2005-08-09 주식회사 엘지생명과학 히알루론산 유도체 및 그의 제조방법
JP5156890B2 (ja) 2002-09-11 2013-03-06 独立行政法人物質・材料研究機構 高分子架橋体及びその製造方法
WO2004046200A1 (ja) 2002-11-21 2004-06-03 Chugai Seiyaku Kabushiki Kaisha 薬物徐放担体
CA2509382A1 (en) 2002-12-17 2004-07-08 Todd C. Zion Stimuli-responsive systems for controlled drug delivery
AU2004205631A1 (en) 2003-01-16 2004-08-05 Genentech, Inc. Synthetic antibody phage libraries
CA2513483C (en) 2003-01-17 2011-11-29 Cornell Research Foundation, Inc. Injectable hydrogel microspheres from aqueous two-phase system
US7332164B2 (en) 2003-03-21 2008-02-19 Enzon Pharmaceuticals, Inc. Heterobifunctional polymeric bioconjugates
WO2004089280A2 (en) 2003-04-08 2004-10-21 Yeda Research And Development Co. Ltd. Reversible pegylated drugs
AU2003901834A0 (en) 2003-04-17 2003-05-01 Clearcoll Pty Ltd Cross-linked polysaccharide compositions
JP2004323454A (ja) 2003-04-25 2004-11-18 Chisso Corp 薬剤
JP4869066B2 (ja) 2003-04-25 2012-02-01 ケイオウエス ライフ サイエンスイズ，インコーポレイテッド 丈夫な超多孔性ヒドロゲルの形成技術
US20050106667A1 (en) 2003-08-01 2005-05-19 Genentech, Inc Binding polypeptides with restricted diversity sequences
WO2005044853A2 (en) * 2003-11-01 2005-05-19 Genentech, Inc. Anti-vegf antibodies
US7758859B2 (en) 2003-08-01 2010-07-20 Genentech, Inc. Anti-VEGF antibodies
WO2005034852A2 (en) 2003-08-26 2005-04-21 Gel-Del Technologies, Inc. Protein biomaterials and biocoacervates and methods of making and using thereof
US7690003B2 (en) 2003-08-29 2010-03-30 Fuller Jeffrey C System and method for increasing data throughput using thread scheduling
US8124120B2 (en) 2003-12-22 2012-02-28 Anika Therapeutics, Inc. Crosslinked hyaluronic acid compositions for tissue augmentation
EP1576952A1 (en) 2004-03-18 2005-09-21 OctoPlus Technologies B.V. Hydrogel microspheres with improved release profile
CA2786794C (en) 2004-03-23 2017-09-12 Complex Biosystems Gmbh Aromatic polymeric cascade prodrug linker reagent
CN1961003B (zh) 2004-03-31 2013-03-27 健泰科生物技术公司 人源化抗TGF-β抗体
US7785903B2 (en) 2004-04-09 2010-08-31 Genentech, Inc. Variable domain library and uses
US8293890B2 (en) 2004-04-30 2012-10-23 Advanced Cardiovascular Systems, Inc. Hyaluronic acid based copolymers
US20050244472A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Intraocular drug delivery systems containing excipients with reduced toxicity and related methods
GB0411583D0 (en) 2004-05-24 2004-06-23 Univ Bath Process
US7968085B2 (en) 2004-07-05 2011-06-28 Ascendis Pharma A/S Hydrogel formulations
WO2006113668A1 (en) 2005-04-15 2006-10-26 University Of South Florida A method of transdermal drug delivery using hyaluronic acid nanoparticles
GB2427360A (en) 2005-06-22 2006-12-27 Complex Biosystems Gmbh Aliphatic prodrug linker
EP1905456A4 (en) 2005-07-06 2010-12-22 Seikagaku Kogyo Co Ltd PHARMACEUTICAL LIGHT-NETWORKED HYALURONIC DERIVATIVE GEL
US8679536B2 (en) 2005-08-24 2014-03-25 Actamax Surgical Materials, Llc Aldol-crosslinked polymeric hydrogel adhesives
KR20080080481A (ko) 2005-09-02 2008-09-04 콜바르 라이프사이언스 리미티드 교차-결합된 다당류 및 단백질 매트릭스 및 그의 제조 방법
AU2006292752A1 (en) 2005-09-15 2007-03-29 University Of Utah Research Foundation Polymeric compositions and methods of making and using thereof
US20090130769A1 (en) 2005-09-21 2009-05-21 Universiteit Van Amsterdam Novel Cross-Linkers For Obtaining Structure Information On Molecule Complexes
US20080306022A1 (en) 2005-10-12 2008-12-11 Kenji Miyamoto Agent for Applying to Mucosa and Method for the Production Thereof
WO2007047997A2 (en) 2005-10-19 2007-04-26 Smartcells, Inc. Methods for reducing the mitogenicity of lectin compositions
EP1957531B1 (en) 2005-11-07 2016-04-13 Genentech, Inc. Binding polypeptides with diversified and consensus vh/vl hypervariable sequences
WO2007064919A2 (en) 2005-12-02 2007-06-07 Genentech, Inc. Binding polypeptides with restricted diversity sequences
EP1968498A2 (en) 2005-12-14 2008-09-17 Anika Therapeutics Inc. Meniscal implant of hyaluronic acid derivatives for treatment of meniscal defects
US7879818B2 (en) 2005-12-23 2011-02-01 Janos Borbely Hyaluronic acid-based cross-linked nanoparticles
US20070202186A1 (en) 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
AU2007240613B2 (en) 2006-04-20 2013-11-28 University Of Utah Research Foundation Polymeric compositions and methods of making and using thereof
EP2016101A2 (en) 2006-05-09 2009-01-21 Genentech, Inc. Binding polypeptides with optimized scaffolds
EP2471816A1 (en) 2006-08-30 2012-07-04 Genentech, Inc. Multispecific antibodies
ITMI20061726A1 (it) 2006-09-11 2008-03-12 Fidia Farmaceutici Derivati crosslinkati a base di acido ialuronico reticolato via click chemistry
WO2008034122A2 (en) 2006-09-15 2008-03-20 Enzon Pharmaceuticals, Inc. Hindered ester-based biodegradable linkers for oligonucleotide delivery
US20080089923A1 (en) 2006-09-29 2008-04-17 Burkstrand Michael J Biodegradable ocular implants and methods for treating ocular conditions
EP1942117A1 (en) 2006-12-29 2008-07-09 Sigea S.R.L. Derivatives of acid polysaccharides
KR20080073419A (ko) 2007-02-06 2008-08-11 주식회사 핸슨바이오텍 의료용 히알루론산 유도체 마이크로비드 및 이의 제조 방법
EP1992364A1 (en) 2007-05-16 2008-11-19 Biosuma S.r.l. Carboxylated polysaccharides phosphated or bisphosphonated derivatives, optionally cross-linked, and their preparation and biomedical uses
CN100592373C (zh) 2007-05-25 2010-02-24 群康科技(深圳)有限公司 液晶显示面板驱动装置及其驱动方法
JP2010533202A (ja) 2007-07-11 2010-10-21 エンゾン ファーマシューティカルズ，インコーポレーテッド 多置換芳香族部分を含むポリマー性薬剤送達システム
US8318695B2 (en) 2007-07-30 2012-11-27 Allergan, Inc. Tunably crosslinked polysaccharide compositions
EP2090592A1 (en) 2007-07-31 2009-08-19 OctoPlus Sciences B.V. Biodegradable hydrogels based on click chemistry
KR101062320B1 (ko) 2007-08-01 2011-09-05 포항공과대학교 산학협력단 가교결합성 히알루론산 유도체 제조방법 및 그 히알루론산유도체의 가교결합물
MX2010001629A (es) 2007-08-10 2010-08-09 Alessandro Sannino Hidrogeles de polimero y metodos de preparacion de los mismos.
JP5579609B2 (ja) 2007-10-11 2014-08-27 アンセルム（アンスチチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル） 組織工学、細胞培養、および細胞送達用の多孔質足場の調製方法
SG185281A1 (en) 2007-10-11 2012-11-29 Inserm Inst Nat De Sante Et De La Rech Medicale Method for preparing porous scaffold for tissue engineering
US20090143348A1 (en) 2007-11-30 2009-06-04 Ahmet Tezel Polysaccharide gel compositions and methods for sustained delivery of drugs
US8394782B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having increased longevity
WO2009077399A1 (en) 2007-12-19 2009-06-25 Evonik Goldschmidt Gmbh Crosslinked hyaluronic acid in emulsion
CA2706183A1 (en) 2007-12-21 2009-07-02 Encecor Ab Cross-linked hydrogel containing an active substance
EP3663318A1 (en) 2008-01-07 2020-06-10 Amgen Inc. Method for making antibody fc-heterodimeric molecules using electrostatic steering effects
LT2237799T (lt) 2008-02-01 2019-07-25 Ascendis Pharma A/S Provaistas, apimantis besiskaidantį linkerį
CN101538377A (zh) 2008-03-20 2009-09-23 上海昊海生物科技有限公司 一种交联透明质酸凝胶及其制备方法
IE20080211A1 (en) 2008-03-20 2009-11-25 Nat Univ Ireland Biodegradable nanoshells for delivery of therapeutic and/or imaging molecules
JP2011517451A (ja) 2008-03-28 2011-06-09 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ポリペプチド−ポリマー抱合体およびその使用方法
WO2009143412A2 (en) 2008-05-23 2009-11-26 Enzon Pharmaceuticals, Inc. Polymeric systems containing intracellular releasable disulfide linker for the delivery of oligonucleotides
US8821870B2 (en) 2008-07-18 2014-09-02 Allergan, Inc. Method for treating atrophic age related macular degeneration
US8357795B2 (en) 2008-08-04 2013-01-22 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
GB0816496D0 (en) 2008-09-10 2008-10-15 Zhao Xiaobin Hyaluronic acid cryogel
CN101721349B (zh) 2008-10-16 2011-07-20 常州百瑞吉生物医药有限公司 可注射原位交联水凝胶及其制备方法和用途
US20100098772A1 (en) 2008-10-21 2010-04-22 Allergan, Inc. Drug delivery systems and methods for treating neovascularization
ITRM20080636A1 (it) 2008-11-28 2010-05-29 Univ Palermo Procedimento per la produzione di derivati funzionalizzati dell acido ialuronico e relativi idrogeli.
US8133979B2 (en) 2008-12-16 2012-03-13 Hoffmann-La Roche Inc. Antibodies against human angiopoietin 2
US11090387B2 (en) 2008-12-22 2021-08-17 The Trustees Of The University Of Pennsylvania Hydrolytically degradable polysaccharide hydrogels
FR2945949B1 (fr) 2009-05-26 2011-05-13 Anteis Sa Hydrogel injectable permettant une supplementation en glycerol dans la peau sur le long terme.
EA201190273A1 (ru) * 2009-05-28 2012-12-28 Глаксо Груп Лимитед Комбинация антагониста tnf-альфа и антагониста vegf для применения в лечении или предупреждении заболеваний глаз
WO2010138074A1 (en) 2009-05-29 2010-12-02 Hilborn Joens Hyaluronic acid based delivery systems
IT1399351B1 (it) 2009-06-16 2013-04-16 Fidia Farmaceutici Procedimento per la sintesi di coniugati di glicosamminoglicani (gag) con molecole biologicamente attive, coniugati polimerici e usi relativi
KR101091028B1 (ko) 2009-07-02 2011-12-09 아주대학교산학협력단 체내 주입형 하이드로젤 및 이의 생의학적 용도
EP2448604B1 (en) 2009-07-02 2016-03-23 Actamax Surgical Materials LLC Hydrogel tissue adhesive for medical use
LT2459220T (lt) 2009-07-31 2020-12-28 Ascendis Pharma A/S Biologiškai suyrantys vandenyje netirpūs hidrogeliai polietilenglikolio pagrindu
US9173953B2 (en) 2009-07-31 2015-11-03 Ascendis Pharma As Prodrugs containing an aromatic amine connected by an amido bond to a linker
JO3008B1 (ar) 2009-08-13 2016-09-05 Seikagaku Kogyo Co Ltd تركيب صيدلي لتخفيف الألم
KR101103423B1 (ko) 2009-09-04 2012-01-06 아주대학교산학협력단 생체 주입형 조직 접착성 하이드로젤 및 이의 생의학적 용도
WO2011066417A2 (en) * 2009-11-24 2011-06-03 Carnegie Mellon University Antibodies and conjugates for modulators of angiogenesis
EP2963111A1 (en) 2009-12-22 2016-01-06 Lifebond Ltd Modification of enzymatic crosslinkers for controlling properties of crosslinked matrices
CN102724967A (zh) 2009-12-31 2012-10-10 安龙制药公司 包括可释放的脲连接体的含芳香胺化合物的聚合缀合物
EP2525829A1 (en) 2010-01-22 2012-11-28 Ascendis Pharma A/S Dipeptide-based prodrug linkers for aromatic amine-containing drugs
EP2525831B1 (en) 2010-01-22 2019-05-15 Ascendis Pharma A/S Carrier-linked carbamate prodrug linkers
US9062094B2 (en) 2010-01-22 2015-06-23 Ascendis Pharma As Dipeptide-based prodrug linkers for aliphatic amine-containing drugs
CA2791050A1 (en) 2010-03-01 2011-09-09 Tautona Group Lp Threads of cross-linked hyaluronic acid and methods of use thereof
JP2013523752A (ja) 2010-03-29 2013-06-17 エボニック デグサ コーポレイション 局所投与部位における医薬組成物の保持改善のための組成物および方法
US8859629B2 (en) 2010-04-27 2014-10-14 Synaffix B.V. Fused cyclooctyne compounds and their use in metal-free click reactions
WO2011140393A1 (en) 2010-05-05 2011-11-10 Prolynx Llc Controlled release from macromolecular conjugates
EP2566334B1 (en) 2010-05-05 2018-04-18 Prolynx, LLC Controlled drug release from solid supports
WO2011148116A2 (fr) 2010-05-27 2011-12-01 Laboratoire Idenov Acide hyaluronique modifie, procede de fabrication et utilisations
WO2011163069A2 (en) 2010-06-21 2011-12-29 The Trustees Of The University Of Pennsylvania Protease triggered release of molecules from hydrogels
JP5937070B2 (ja) 2010-06-22 2016-06-22 ウニヴェルシテ ド ルアンＵｎｉｖｅｒｓｉｔｅ Ｄｅ Ｒｏｕｅｎ ３ｄ細胞培養に用いる改良された架橋ヒアルロナンヒドロゲル
IT1401498B1 (it) 2010-07-30 2013-07-26 Mero Srl Idrogelo a base di acido ialuronico e suo uso in ortopedia
US20130274222A1 (en) 2010-10-20 2013-10-17 Tautona Group Lp Threads of cross-linked hyaluronic acid and methods of preparation and use thereof
FR2967677B1 (fr) 2010-11-18 2014-05-16 Centre Nat Rech Scient Derives de polysaccharides comprenant un motif alcene et reaction de couplage par chimie thio-clic
US20140038826A1 (en) 2011-01-28 2014-02-06 The Regents Of The University Of Colorado, A Body Corporate Covalently cross linked hydrogels and methods of making and using same
EP2682409B1 (en) 2011-03-03 2017-07-05 Chugai Seiyaku Kabushiki Kaisha Derivative of hyaluronic acid modified with amino-carboxylic acid
CZ304072B6 (cs) 2011-04-26 2013-09-25 Contipro Biotech S.R.O. Amfoterní materiál na bázi sítované kyseliny hyaluronové, zpusob jeho prípravy, materiály obsahující aktivní cinidla uzavrené v síti hyaluronanu, zpusob jejich prípravy a jejich pouzití
ES2685327T3 (es) 2011-04-28 2018-10-08 President And Fellows Of Harvard College Armazones tridimensionales macroscópicos preformados inyectables para administración mínimamente invasiva
US20140256831A1 (en) 2011-05-31 2014-09-11 The University Of Tokyo Hydrogel and method for producing same
RU2624239C2 (ru) 2011-06-03 2017-07-03 Аллерган, Инк. Составы кожного наполнителя, включая антиоксиданты
CN102226009B (zh) 2011-06-09 2013-04-10 西安力邦制药有限公司 一种交联透明质酸凝胶的制备方法
WO2012171335A1 (en) 2011-06-16 2012-12-20 The Hong Kong University Of Science And Technology Multi-vinylsulfone containing molecule
EP3643306A3 (en) 2011-08-12 2020-08-26 Ascendis Pharma A/S Carrier-linked prodrugs having reversible carboxylic ester linkages
US9044515B2 (en) 2011-09-06 2015-06-02 University Of Delaware Chemical conjugates for targeted degradation under reducing conditions
SG11201400444VA (en) 2011-09-07 2014-04-28 Prolynx Llc Hydrogels with biodegradable crosslinking
WO2013036857A1 (en) 2011-09-07 2013-03-14 Prolynx Llc Sulfone linkers
US20130066063A1 (en) 2011-09-09 2013-03-14 John Cooke Hodges Bicyclo[6.1.0]non-4-yne regents for chemical modification of oligonucleotides
EP3243533B1 (en) 2011-10-11 2020-06-17 Allergan Holdings France S.A.S. Threads of cross-linked hyaluronic acid and methods of use thereof
KR20140059238A (ko) 2011-11-11 2014-05-15 미바 메디컬 아이엔시. 주사 시술용 보형물
US20140107025A1 (en) 2012-04-16 2014-04-17 Jade Therapeutics, Llc Ocular drug delivery system
EP2841109B1 (en) 2012-04-25 2026-04-15 Ascendis Pharma A/S Prodrugs of hydroxyl-comprising drugs
KR101374271B1 (ko) 2012-05-02 2014-03-14 주식회사 제네웰 히알루론산 에폭사이드 가교체 및 그 제조방법
EP2852664B1 (en) 2012-05-18 2017-09-06 Medical Research Council Methods of incorporating an amino acid comprising a bcn group into a polypeptide using an orthogonal codon encoding it and an orthorgonal pylrs synthase.
SI3495387T1 (sl) 2012-07-13 2021-12-31 Roche Glycart Ag Bispecifična protitelesa proti VEGF/proti ANG-2 in njihova uporaba pri zdravljenju bolezni očesnih žil
CZ304512B6 (cs) 2012-08-08 2014-06-11 Contipro Biotech S.R.O. Derivát kyseliny hyaluronové, způsob jeho přípravy, způsob jeho modifikace a použití
US9827321B2 (en) 2012-08-14 2017-11-28 The Trustees Of The University Of Pennsylvania Stabilizing shear-thinning hydrogels
WO2014048564A1 (en) 2012-09-25 2014-04-03 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. "novel cross-linkers for hydrogels, hydrogels including these cross-linkers and applications thereof"
DK2906246T3 (da) 2012-10-11 2023-09-04 Ascendis Pharma Ophthalmology Div A/S VEGF-neutraliserende prodrugs omfattende ranibizumab til behandling af okulære tilstande, der er kendetegnet ved okulær neovaskularisering
CN102942699B (zh) 2012-10-26 2014-07-02 暨南大学 一种自增强双交联透明质酸水凝胶及其制备方法
CN102911380B (zh) 2012-10-29 2015-03-18 北京爱美客生物科技有限公司 透明质酸与生物可降解高分子改性材料及制备方法
WO2014169301A1 (en) 2013-04-12 2014-10-16 Bui The Duy Systems and methods for delivering cross-linked halyuronic acid into a patient
EP2727597A1 (en) 2012-11-06 2014-05-07 Centre National de la Recherche Scientifique (CNRS) Glucose responsive hydrogel comprising pba-grafted hyaluronic acid (ha)
ITPD20120360A1 (it) 2012-11-30 2014-05-31 Fidia Farmaceutici "nuovi geli viscoelastici in chirurgia oftalmica"
KR20150095684A (ko) * 2012-12-18 2015-08-21 노파르티스 아게 히알루로난에 결합하는 펩티드 태그를 이용하는 조성물 및 방법
WO2014096257A1 (en) 2012-12-19 2014-06-26 Novozymes Biopharma Dk A/S Freeze-dried cross-linked hyaluronic acid sponge
US9498539B2 (en) 2012-12-27 2016-11-22 Molly Sandra Shoichet Affinity-based controlled release system
CN105007896B (zh) 2012-12-28 2019-04-09 雅培心血管系统公司 包含抗体的治疗组合物
WO2014138897A1 (en) 2013-03-14 2014-09-18 Anacoti Ltd. Hyaluronic acid derivatives
CN105188667A (zh) 2013-03-27 2015-12-23 佛多斯大学医学研究中心(C·H·U·V) 用于治疗和/或预防再狭窄的药物制剂
US20150190517A1 (en) 2013-04-12 2015-07-09 Miba Medical Inc. Systems and methods for delivering cross-linked halyuronic acid into a patient
WO2014169298A1 (en) 2013-04-12 2014-10-16 Bui The Duy Timing controlled in-situ cross-linking ofhalyuronic acid during injection
WO2014169299A1 (en) 2013-04-12 2014-10-16 Bui The Duy Temperature-release catalyst for cross-linking halyuronic acid during injection
US11116849B2 (en) * 2013-04-22 2021-09-14 Ascendis Pharma A/S Hydrogel-linked prodrugs releasing tagged drugs
EP2988755A4 (en) 2013-04-25 2016-11-30 Aluron Biopharma Inc RETICULATED HYALURONIC ACID COMPOSITIONS
US10137199B2 (en) 2013-05-14 2018-11-27 Biotime, Inc. Thiolated hyaluronan-based hydrogels cross-linked using oxidized glutathione
FR3006689A1 (fr) 2013-06-11 2014-12-12 Benedicte Vincente Tauzin Procede de reticulation de l'acide hyaluronique; procede de preparation d'un hydrogel injectable; hydrogel obtenu; utilisation de l'hydroget obtenu
CA2914765A1 (en) 2013-06-14 2014-12-18 Galderma S.A. Compositions comprising cross-linked hyaluronic acid and cyclodextrin
RU2640865C2 (ru) 2013-06-28 2018-01-12 Гальдерма С.А. Способ производства формованного продукта из поперечно-сшитой гиалуроновой кислоты
EP3016634A2 (en) 2013-07-05 2016-05-11 Therakine Biodelivery GmbH Drug-delivery composition for topical applications and injections and ophtalmic formulations, method for manufacturing thereof, and methods for delivery a drug-delivery composition
WO2015048408A1 (en) 2013-09-27 2015-04-02 Virginia Tech Intellectual Properties, Inc. Cross-metathesized polysaccharide derivatives and processes for preparing them
CA2925190C (en) 2013-10-08 2021-10-12 Ascendis Pharma A/S Protecting group comprising a purification tag
WO2015053281A1 (ja) 2013-10-08 2015-04-16 キユーピー株式会社 カルボキシメチル基含有修飾ヒアルロン酸および／またはその塩の架橋物およびその製造方法
WO2015053282A1 (ja) 2013-10-08 2015-04-16 キユーピー株式会社 カルボキシメチル基含有修飾ヒアルロン酸および／またはその塩の架橋物およびその製造方法
US9782345B2 (en) 2013-10-17 2017-10-10 Jade Therapeutics, Inc. Ocular composition and method
KR101459070B1 (ko) 2013-12-09 2014-11-17 (주) 뉴메딕 지속성을 갖는 히알루론산 겔 조성물
RU2016133980A (ru) * 2014-01-23 2018-03-01 Экебиа Терапьютикс, Инк. Композиции и способы для лечения заболеваний глаз
ES2993327T3 (en) 2014-08-06 2024-12-27 Ascendis Pharma As Prodrugs comprising an aminoalkyl glycine linker
WO2016073157A1 (en) 2014-11-06 2016-05-12 Genentech, Inc. Anti-ang2 antibodies and methods of use thereof
SI3215530T1 (sl) 2014-11-07 2020-02-28 Sesen Bio, Inc. Izboljšana protitelesa IL-6
WO2016196124A2 (en) 2015-05-29 2016-12-08 Ascendis Pharma Inc. Prodrugs comprising a pyroglutamate linker
EP3302569A1 (en) 2015-05-29 2018-04-11 Albatross Technologies Limited Cross-linked hyaluronic acid for drug delivery and pharmaceutical preparation using same
JP6959912B2 (ja) 2015-09-23 2021-11-05 ジェネンテック， インコーポレイテッド 抗ｖｅｇｆ抗体の最適化変異体
KR102944785B1 (ko) 2015-12-09 2026-03-30 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 안구 질환 또는 장애의 치료 방법
AR110299A1 (es) 2016-12-02 2019-03-13 Sanofi Sa Conjugados que comprenden un agonista dual de glp-1 / glucagón, un conector y ácido hialurónico
JP7216006B2 (ja) * 2017-03-22 2023-01-31 ジェネンテック， インコーポレイテッド ヒドロゲル架橋ヒアルロン酸プロドラッグ組成物及び方法

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100210509A1 (en) 2007-10-09 2010-08-19 Postech Academy-Industry Foundation Long acting hyaluronic acid - peptide conjugate
JP2013501781A (ja) 2009-08-11 2013-01-17 エージェンシー フォー サイエンス， テクノロジー アンド リサーチ 生体活性物質の細胞送達のための粒子状ヒアルロン酸製剤
JP2014528465A (ja) 2011-10-12 2014-10-27 アセンディス ファーマ オフサルモロジー ディヴィジョン エー／エス 眼の状態の予防及び治療
US20140080897A1 (en) 2012-09-18 2014-03-20 Postech Academy-Industry Foundation Hyaluronic acid-nucleic acid conjugate and composition for nucleic acid delivery containing the same
US20160002366A1 (en) 2013-02-20 2016-01-07 The University Of Queensland Conjugate compound and uses of same
US20140294752A1 (en) 2013-04-01 2014-10-02 Research & Business Foundation Sungkyunkwan University Method for nucleic acid delivery using hyaluronic acid
WO2016193371A1 (en) 2015-06-05 2016-12-08 Sanofi Prodrugs comprising an glp-1/glucagon dual agonist linker hyaluronic acid conjugate

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J. Mater. Chem. B，2016年，Vol.4，pp.2803-2818

Also Published As

Publication number Publication date
KR102715397B1 (ko) 2024-10-10
NZ757216A (en) 2026-01-30
US20230414770A1 (en) 2023-12-28
BR112019019658A2 (pt) 2020-04-22
TWI857935B (zh) 2024-10-11
IL269506B1 (en) 2023-12-01
RU2019133326A (ru) 2021-04-22
KR20200007776A (ko) 2020-01-22
IL269506A (en) 2019-11-28
AU2018240375A2 (en) 2020-03-05
AU2018240375C1 (en) 2024-02-01
EP3600441A1 (en) 2020-02-05
IL269506B2 (en) 2024-04-01
JP2023058511A (ja) 2023-04-25
MA49265A (fr) 2020-02-05
CN110891611A (zh) 2020-03-17
SG11201908547VA (en) 2019-10-30
AU2018240375B2 (en) 2023-08-03
ZA201905930B (en) 2024-01-31
US20250255973A1 (en) 2025-08-14
US12246070B2 (en) 2025-03-11
KR20240150530A (ko) 2024-10-15
AR111190A1 (es) 2019-06-12
CN110891611B (zh) 2024-03-29
RU2019133326A3 (cg-RX-API-DMAC10.html) 2021-10-19
TW201842936A (zh) 2018-12-16
WO2018175788A1 (en) 2018-09-27
AU2018240375A1 (en) 2019-09-26
JP2020515545A (ja) 2020-05-28
CA3055985A1 (en) 2018-09-27
US11642415B2 (en) 2023-05-09
SG10202107829YA (en) 2021-08-30
US20200222547A1 (en) 2020-07-16

Similar Documents

Publication Publication Date Title
US12246070B2 (en) Hydrogel cross-linked hyaluronic acid prodrug compositions and methods
US11891437B2 (en) Methods of treating ocular disorders by administering a VEGF-binding antibody covalently linked to a hyaluronic acid polymer
US20210115124A1 (en) Optimized variants of anti-vegf antibodies
ES2690312T3 (es) Anticuerpos biespecíficos anti-VEGF/anti-ANG-2 y su uso en el tratamiento de enfermedades vasculares oculares
RU2812787C2 (ru) Пролекарственные композиции на основе гидрогеля поперечно-сшитой гиалуроновой кислоты и способы
CA3055985C (en) Hydrogel cross-linked hyaluronic acid prodrug compositions and methods
BR122022024506B1 (pt) Composições farmacêuticas compreendendo conjugados fármacoácido hialurônico e uso destas na fabricação de um medicamento para tratar uma indicação ocular
BR112019019658B1 (pt) Conjugado de fármaco-ácido hialurônico, seu método de produção, composição farmacêutica e uso da mesma
RU2782355C2 (ru) Оптимизированные композиции антител для лечения заболеваний глаз
HK40098460A (en) Optimized variants of anti-vegf antibodies
BR112018005737B1 (pt) Anticorpo isolado, composições farmacêuticas, conjugados de anticorpo, proteína de fusão e usos do anticorpo
HK1254198B (en) Optimized variants of anti-vegf antibodies
BR112015000800B1 (pt) Método para a redução da viscosidade de um anticorpo, anticorpos biespecíficos, composição farmacêutica compreendendo um anticorpo, método para preparação de um anticorpo biespecífico e anticorpos biespecíficos bivalentes

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210322

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20210322

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20211210

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20220322

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20220618

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20220819

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220922

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20221220

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20230119

R150 Certificate of patent or registration of utility model

Ref document number: 7216006

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313117

S531 Written request for registration of change of domicile

Free format text: JAPANESE INTERMEDIATE CODE: R313531

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250