JP6778114B2 - イミド系タンパク質分解モジュレーター及び関連する使用方法 - Google Patents
イミド系タンパク質分解モジュレーター及び関連する使用方法 Download PDFInfo
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- JP6778114B2 JP6778114B2 JP2016563103A JP2016563103A JP6778114B2 JP 6778114 B2 JP6778114 B2 JP 6778114B2 JP 2016563103 A JP2016563103 A JP 2016563103A JP 2016563103 A JP2016563103 A JP 2016563103A JP 6778114 B2 JP6778114 B2 JP 6778114B2
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- dihydro
- dioxopiperidine
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- ethoxy
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- 0 *=C(CCCC1=N)*1N Chemical compound *=C(CCCC1=N)*1N 0.000 description 7
- AONNGYBECNOVTK-UHFFFAOYSA-N CCOc1cc(-c2c(C)[o]nc2C)cc(C(C)O)c1 Chemical compound CCOc1cc(-c2c(C)[o]nc2C)cc(C(C)O)c1 AONNGYBECNOVTK-UHFFFAOYSA-N 0.000 description 1
- LJOSBOOJFIRCSO-AWEZNQCLSA-N Cc1c(C)[s]c-2c1C(c(cc1)ccc1Cl)=N[C@@H](CC(O)=O)c1nnc(C)[n]-21 Chemical compound Cc1c(C)[s]c-2c1C(c(cc1)ccc1Cl)=N[C@@H](CC(O)=O)c1nnc(C)[n]-21 LJOSBOOJFIRCSO-AWEZNQCLSA-N 0.000 description 1
- QTFDOBJYFQFDIO-UHFFFAOYSA-N Nc(cc1)ccc1OCCOCCOCCOCCNc1cccc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O Chemical compound Nc(cc1)ccc1OCCOCCOCCOCCNc1cccc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O QTFDOBJYFQFDIO-UHFFFAOYSA-N 0.000 description 1
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
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| EP3302482A4 (en) * | 2015-06-05 | 2018-12-19 | Arvinas, Inc. | Tank-binding kinase-1 protacs and associated methods of use |
| HUE061847T2 (hu) * | 2016-10-11 | 2023-08-28 | Arvinas Operations Inc | Androgén receptor célzott degradálására alkalmas vegyületek és eljárások |
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