BR112022016901A2 - Compostos de degradação do receptor de tropomiosina quinase (trk) e métodos de uso - Google Patents
Compostos de degradação do receptor de tropomiosina quinase (trk) e métodos de usoInfo
- Publication number
- BR112022016901A2 BR112022016901A2 BR112022016901A BR112022016901A BR112022016901A2 BR 112022016901 A2 BR112022016901 A2 BR 112022016901A2 BR 112022016901 A BR112022016901 A BR 112022016901A BR 112022016901 A BR112022016901 A BR 112022016901A BR 112022016901 A2 BR112022016901 A2 BR 112022016901A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- methods
- trk
- receptor
- degradating
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 4
- 108010090229 tropomyosin kinase Proteins 0.000 title abstract 4
- 230000001588 bifunctional effect Effects 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- -1 small molecule compounds Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychiatry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
COMPOSTOS DE DEGRADAÇÃO DO RECEPTOR DE TROPOMIOSINA QUINASE (TRK) E MÉTODOS DE USO. Esta divulgação refere-se a compostos bivalentes (por exemplo, compostos de moléculas pequenas bifuncionais), composições compreendendo um ou mais dos compostos bivalentes e a métodos de uso dos compostos bivalentes para o tratamento de certas doenças em um sujeito em necessidade. A divulgação também se refere a métodos para identificar tais compostos bivalentes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2020076748 | 2020-02-26 | ||
PCT/CN2021/078240 WO2021170109A1 (en) | 2020-02-26 | 2021-02-26 | Tropomyosin receptor kinase (trk) degradation compounds and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022016901A2 true BR112022016901A2 (pt) | 2022-12-06 |
Family
ID=77490737
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022016901A BR112022016901A2 (pt) | 2020-02-26 | 2021-02-26 | Compostos de degradação do receptor de tropomiosina quinase (trk) e métodos de uso |
Country Status (11)
Country | Link |
---|---|
US (1) | US20230257380A1 (pt) |
EP (1) | EP4110772A4 (pt) |
JP (1) | JP2023514872A (pt) |
KR (1) | KR20230010070A (pt) |
CN (1) | CN115697989A (pt) |
AU (1) | AU2021225981A1 (pt) |
BR (1) | BR112022016901A2 (pt) |
CA (1) | CA3173262A1 (pt) |
IL (1) | IL295799A (pt) |
MX (1) | MX2022010465A (pt) |
WO (1) | WO2021170109A1 (pt) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11969472B2 (en) | 2018-08-22 | 2024-04-30 | Cullgen (Shanghai), Inc. | Tropomyosin receptor kinase (TRK) degradation compounds and methods of use |
KR20210069634A (ko) * | 2018-08-22 | 2021-06-11 | 클루젠 (상하이), 인크. | 트로포미오신 수용체 키나아제(trk) 분해 화합물 및 사용 방법 |
CN116648248A (zh) * | 2021-01-26 | 2023-08-25 | 成都茵创园医药科技有限公司 | 芳香化合物、含其的药物组合物及其应用 |
CN115504963A (zh) * | 2021-06-22 | 2022-12-23 | 苏州开拓药业股份有限公司 | 一种c-Myc蛋白降解剂 |
EP4400499A1 (en) * | 2021-09-08 | 2024-07-17 | Medshine Discovery Inc. | Glutarimide compound and use thereof |
WO2023055952A1 (en) * | 2021-09-29 | 2023-04-06 | C4 Therapeutics, Inc. | Neurotrophic tyrosine receptor kinase (ntrk) degrading compounds |
AU2022370021A1 (en) * | 2021-10-22 | 2024-05-09 | Gluetacs Therapeutics (Shanghai) Co., Ltd. | Crbn e3 ligase ligand compound, protein degrading agent developed on the basis of ligand compound, and their applications |
EP4180428A1 (en) * | 2021-11-12 | 2023-05-17 | Genzyme Corporation | Crystalline imidazo[4,5-b]pyridine compound, pharmaceutical compositions, and their use in treating medical conditions |
WO2023116835A1 (zh) * | 2021-12-24 | 2023-06-29 | 苏州开拓药业股份有限公司 | 一种具有酰亚胺骨架的多蛋白降解剂 |
TW202333670A (zh) * | 2022-01-04 | 2023-09-01 | 大陸商海思科醫藥集團股份有限公司 | 抑制並降解irak4的化合物及其藥物组合物和藥學上的應用 |
WO2023193760A1 (en) * | 2022-04-06 | 2023-10-12 | Cullgen (Shanghai) , Inc. | Compounds and methods of treating cancers |
US20230416240A1 (en) * | 2022-06-16 | 2023-12-28 | Prelude Therapeutics Incorporated | Kat6 targeting compounds |
TW202412851A (zh) * | 2022-08-05 | 2024-04-01 | 大陸商深圳市新樾生物科技有限公司 | 蛋白激酶降解劑、藥物及應用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20210132233A (ko) * | 2014-04-14 | 2021-11-03 | 아비나스 오퍼레이션스, 인코포레이티드 | 단백질분해의 이미드-기초된 조절인자 및 연관된 이용 방법 |
WO2016096709A1 (en) * | 2014-12-16 | 2016-06-23 | Eudendron S.R.L. | Heterocyclic derivatives modulating activity of certain protein kinases |
EP3270917A4 (en) * | 2015-03-18 | 2018-08-08 | Arvinas, Inc. | Compounds and methods for the enhanced degradation of targeted proteins |
WO2017197046A1 (en) * | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | C3-carbon linked glutarimide degronimers for target protein degradation |
EP3455219A4 (en) * | 2016-05-10 | 2019-12-18 | C4 Therapeutics, Inc. | AMINE-LINKED C3-GLUTARIMIDE DEGRONIMERS FOR THE DEGRADATION OF TARGET PROTEINS |
EP3454856A4 (en) * | 2016-05-10 | 2019-12-25 | C4 Therapeutics, Inc. | HETEROCYCLIC DEGRONIMERS FOR TARGET PROTEIN REDUCTION |
JP2021506820A (ja) * | 2017-12-13 | 2021-02-22 | 上海科技大学Shanghai Tech University | Alkタンパク質分解剤及びそれらの癌療法における使用 |
KR20210069634A (ko) * | 2018-08-22 | 2021-06-11 | 클루젠 (상하이), 인크. | 트로포미오신 수용체 키나아제(trk) 분해 화합물 및 사용 방법 |
-
2021
- 2021-02-26 BR BR112022016901A patent/BR112022016901A2/pt unknown
- 2021-02-26 CN CN202180031506.7A patent/CN115697989A/zh active Pending
- 2021-02-26 CA CA3173262A patent/CA3173262A1/en active Pending
- 2021-02-26 IL IL295799A patent/IL295799A/en unknown
- 2021-02-26 AU AU2021225981A patent/AU2021225981A1/en active Pending
- 2021-02-26 KR KR1020227033274A patent/KR20230010070A/ko unknown
- 2021-02-26 EP EP21760113.7A patent/EP4110772A4/en active Pending
- 2021-02-26 WO PCT/CN2021/078240 patent/WO2021170109A1/en unknown
- 2021-02-26 MX MX2022010465A patent/MX2022010465A/es unknown
- 2021-02-26 US US17/904,822 patent/US20230257380A1/en active Pending
- 2021-02-26 JP JP2022551553A patent/JP2023514872A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
KR20230010070A (ko) | 2023-01-17 |
EP4110772A4 (en) | 2024-04-03 |
US20230257380A1 (en) | 2023-08-17 |
JP2023514872A (ja) | 2023-04-11 |
MX2022010465A (es) | 2022-12-13 |
WO2021170109A1 (en) | 2021-09-02 |
CN115697989A (zh) | 2023-02-03 |
EP4110772A1 (en) | 2023-01-04 |
AU2021225981A1 (en) | 2022-09-29 |
IL295799A (en) | 2022-10-01 |
CA3173262A1 (en) | 2021-09-02 |
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