CA2945975C - Imide-based modulators of proteolysis and associated methods of use - Google Patents

Imide-based modulators of proteolysis and associated methods of use Download PDF

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Publication number
CA2945975C
CA2945975C CA2945975A CA2945975A CA2945975C CA 2945975 C CA2945975 C CA 2945975C CA 2945975 A CA2945975 A CA 2945975A CA 2945975 A CA2945975 A CA 2945975A CA 2945975 C CA2945975 C CA 2945975C
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disease
dihydro
syndrome
cancer
oxo
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French (fr)
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CA2945975A1 (en
Inventor
Craig Crews
Andrew P. Crew
Hanqing Dong
Jing Wang
Yimin Qian
Meizhong Jin
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Arvinas Operations Inc
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Arvinas Operations Inc
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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