JP2017513862A5 - - Google Patents

Info

Publication number

JP2017513862A5

JP2017513862A5 JP2016563103A JP2016563103A JP2017513862A5 JP 2017513862 A5 JP2017513862 A5 JP 2017513862A5 JP 2016563103 A JP2016563103 A JP 2016563103A JP 2016563103 A JP2016563103 A JP 2016563103A JP 2017513862 A5 JP2017513862 A5 JP 2017513862A5

Authority

JP

Japan

Prior art keywords

syndrome

disease

alkyl

dioxo

dihydro

Prior art date

2015-04-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 125000000217 alkyl group Chemical group 0.000 claims 43
• -1 4- {3- [3- (2-{[2- (2,6-dioxopiperidin-3-yl) -1,3-dioxo-2,3-dihydro-1H-iso Indol-4-yl] amino} ethoxy) propoxy] propoxy} phenyl Chemical group 0.000 claims 42
• 208000011580 syndromic disease Diseases 0.000 claims 39
• 150000001875 compounds Chemical class 0.000 claims 34
• 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 16
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 15
• DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 14
• 201000010099 disease Diseases 0.000 claims 14
• 239000008194 pharmaceutical composition Substances 0.000 claims 14
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 14
• 125000000753 cycloalkyl group Chemical group 0.000 claims 12
• 230000008685 targeting Effects 0.000 claims 12
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• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 10
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• 125000005647 linker group Chemical group 0.000 claims 8
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• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 5
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• 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 5
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• UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 claims 4
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