JP6027611B2 - 複素環式化合物及びその使用 - Google Patents
複素環式化合物及びその使用 Download PDFInfo
- Publication number
- JP6027611B2 JP6027611B2 JP2014521731A JP2014521731A JP6027611B2 JP 6027611 B2 JP6027611 B2 JP 6027611B2 JP 2014521731 A JP2014521731 A JP 2014521731A JP 2014521731 A JP2014521731 A JP 2014521731A JP 6027611 B2 JP6027611 B2 JP 6027611B2
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- compound
- heteroaryl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 BN(C(C(*)*(C)NC)=Cc1c2c(C)c[s]1)C2=O Chemical compound BN(C(C(*)*(C)NC)=Cc1c2c(C)c[s]1)C2=O 0.000 description 12
- STFGZAITFFZDBU-UHFFFAOYSA-N CNc1ncnc2c1nc[s]2 Chemical compound CNc1ncnc2c1nc[s]2 STFGZAITFFZDBU-UHFFFAOYSA-N 0.000 description 5
- UYNSQOJBUWTJMF-UHFFFAOYSA-N Cc1c2nc[s]c2ncn1 Chemical compound Cc1c2nc[s]c2ncn1 UYNSQOJBUWTJMF-UHFFFAOYSA-N 0.000 description 3
- VTUCGBOFBDIMQT-ALCCZGGFSA-N C/C(/NC)=C1/N=CSC1=C Chemical compound C/C(/NC)=C1/N=CSC1=C VTUCGBOFBDIMQT-ALCCZGGFSA-N 0.000 description 1
- RCGIXNDMFJTAJV-UHFFFAOYSA-O CC(C(N1c2ccccc2)=Cc2cccc(-c(cccc3)c3OC)c2C1=O)[NH2+]c1ncnc2c1nc[s]2 Chemical compound CC(C(N1c2ccccc2)=Cc2cccc(-c(cccc3)c3OC)c2C1=O)[NH2+]c1ncnc2c1nc[s]2 RCGIXNDMFJTAJV-UHFFFAOYSA-O 0.000 description 1
- KGKYVSRZDPSQCA-UHFFFAOYSA-N CC(C)=C1N=CSC1=C Chemical compound CC(C)=C1N=CSC1=C KGKYVSRZDPSQCA-UHFFFAOYSA-N 0.000 description 1
- GLKJIBBFJOPTTB-HGQUCJLOSA-N CC(C/C=C\C=C)N(C([C@H](C)Nc1ncnc2c1nc[s]2)=Cc1cccc(/C=C/c2ccccc2)c11)C1=O Chemical compound CC(C/C=C\C=C)N(C([C@H](C)Nc1ncnc2c1nc[s]2)=Cc1cccc(/C=C/c2ccccc2)c11)C1=O GLKJIBBFJOPTTB-HGQUCJLOSA-N 0.000 description 1
- UDQGLHSAVBHNMC-UHFFFAOYSA-N CCC(N1)=Cc(cccc2-c3cncc(OC)c3)c2C1=O Chemical compound CCC(N1)=Cc(cccc2-c3cncc(OC)c3)c2C1=O UDQGLHSAVBHNMC-UHFFFAOYSA-N 0.000 description 1
- DCEPSHFERCWCFM-UHFFFAOYSA-N CCC(N1)=Cc2cccc(-c3cnccc3)c2C1=O Chemical compound CCC(N1)=Cc2cccc(-c3cnccc3)c2C1=O DCEPSHFERCWCFM-UHFFFAOYSA-N 0.000 description 1
- GHUUYQCZAUXEKV-SYXJSHHDSA-N CCC(N1)=Cc2cccc(/C(/C=N)=C/N)c2C1=O Chemical compound CCC(N1)=Cc2cccc(/C(/C=N)=C/N)c2C1=O GHUUYQCZAUXEKV-SYXJSHHDSA-N 0.000 description 1
- HHNDEBADHNXSEI-UHFFFAOYSA-N CCC(N1c2ccccc2)=Cc2cccc(-c(cc3C)cnc3F)c2C1=O Chemical compound CCC(N1c2ccccc2)=Cc2cccc(-c(cc3C)cnc3F)c2C1=O HHNDEBADHNXSEI-UHFFFAOYSA-N 0.000 description 1
- KCXHPEPJMHKYON-UHFFFAOYSA-N CCC(N1c2ccccc2)=Cc2cccc(-c3c[nH]nc3)c2C1=O Chemical compound CCC(N1c2ccccc2)=Cc2cccc(-c3c[nH]nc3)c2C1=O KCXHPEPJMHKYON-UHFFFAOYSA-N 0.000 description 1
- HXRPSYOWXSLWHC-UHFFFAOYSA-N CCC(N1c2ccccc2)=Cc2cccc(-c3c[o]cc3)c2C1=O Chemical compound CCC(N1c2ccccc2)=Cc2cccc(-c3c[o]cc3)c2C1=O HXRPSYOWXSLWHC-UHFFFAOYSA-N 0.000 description 1
- NBMSOBUWMVRSGP-UHFFFAOYSA-N CCC(N1c2ccccc2)=Cc2cccc(-c3cc(C)ncc3)c2C1=O Chemical compound CCC(N1c2ccccc2)=Cc2cccc(-c3cc(C)ncc3)c2C1=O NBMSOBUWMVRSGP-UHFFFAOYSA-N 0.000 description 1
- PMFJBJKMHFNSEA-UHFFFAOYSA-N CCC(N1c2ccccc2)=Cc2cccc(-c3ccncc3)c2C1=O Chemical compound CCC(N1c2ccccc2)=Cc2cccc(-c3ccncc3)c2C1=O PMFJBJKMHFNSEA-UHFFFAOYSA-N 0.000 description 1
- UHTOPMYFHNFFAV-UHFFFAOYSA-N CCC(N1c2ccccc2)=Cc2cccc(-c3cnc4[nH]ccc4c3)c2C1=O Chemical compound CCC(N1c2ccccc2)=Cc2cccc(-c3cnc4[nH]ccc4c3)c2C1=O UHTOPMYFHNFFAV-UHFFFAOYSA-N 0.000 description 1
- VBQPGSUFPDEKLX-CCCKRHTOSA-N CCC(N1c2ccccc2)=Cc2cccc(/C(/C=N)=C/N)c2C1=O Chemical compound CCC(N1c2ccccc2)=Cc2cccc(/C(/C=N)=C/N)c2C1=O VBQPGSUFPDEKLX-CCCKRHTOSA-N 0.000 description 1
- CFVQGDNCZZLUGE-LWOZTNPUSA-N CCC[n]1ncc(-c(cccc2C=C([C@H](C)N/C(/C)=C3\N=CSC3=C)N3)c2C3=O)c1 Chemical compound CCC[n]1ncc(-c(cccc2C=C([C@H](C)N/C(/C)=C3\N=CSC3=C)N3)c2C3=O)c1 CFVQGDNCZZLUGE-LWOZTNPUSA-N 0.000 description 1
- LNCKABOVKZKINE-KRWDZBQOSA-N C[C@@H](C(N1c2ccccc2)=Cc2cccc(-c(ccnc3)c3OC)c2C1=O)Nc1ncnc2c1nc[s]2 Chemical compound C[C@@H](C(N1c2ccccc2)=Cc2cccc(-c(ccnc3)c3OC)c2C1=O)Nc1ncnc2c1nc[s]2 LNCKABOVKZKINE-KRWDZBQOSA-N 0.000 description 1
- POZSOBCNWSXNOA-INIZCTEOSA-N C[C@@H](C(N1c2ccccc2)=Cc2cccc(-c3c(C)[n](C)nc3)c2C1=O)Nc1ncnc2c1nc[s]2 Chemical compound C[C@@H](C(N1c2ccccc2)=Cc2cccc(-c3c(C)[n](C)nc3)c2C1=O)Nc1ncnc2c1nc[s]2 POZSOBCNWSXNOA-INIZCTEOSA-N 0.000 description 1
- JJLHENLTJLAMCK-TVDRNXLFSA-N C[C@@H](C(N1c2ccccc2)=Cc2cccc(-c3c[n](C)nc3C)c2C1=O)N/C(/C)=C1\N=CSC1=C Chemical compound C[C@@H](C(N1c2ccccc2)=Cc2cccc(-c3c[n](C)nc3C)c2C1=O)N/C(/C)=C1\N=CSC1=C JJLHENLTJLAMCK-TVDRNXLFSA-N 0.000 description 1
- YRKJFOMEAUBLBZ-KRWDZBQOSA-N C[C@@H](C(N1c2ccccc2)=Cc2cccc(-c3cc4ccccc4nc3)c2C1=O)N Chemical compound C[C@@H](C(N1c2ccccc2)=Cc2cccc(-c3cc4ccccc4nc3)c2C1=O)N YRKJFOMEAUBLBZ-KRWDZBQOSA-N 0.000 description 1
- ZBMLNRDJUVASJT-IBGZPJMESA-N C[C@@H](C(N1c2ccccc2)=Cc2cccc(-c3cnc(C)c(C)c3)c2C1=O)Nc1ncnc2c1nc[s]2 Chemical compound C[C@@H](C(N1c2ccccc2)=Cc2cccc(-c3cnc(C)c(C)c3)c2C1=O)Nc1ncnc2c1nc[s]2 ZBMLNRDJUVASJT-IBGZPJMESA-N 0.000 description 1
- PLWFDXRGHNEYCH-APHAIJBRSA-N C[C@@H](C(N1c2ccccc2)=Cc2cccc(/C=C/c3ccccc3)c2C1=O)Nc1ncnc2c1nc[s]2 Chemical compound C[C@@H](C(N1c2ccccc2)=Cc2cccc(/C=C/c3ccccc3)c2C1=O)Nc1ncnc2c1nc[s]2 PLWFDXRGHNEYCH-APHAIJBRSA-N 0.000 description 1
- GXRZDBJZLNTOBK-HNNXBMFYSA-N C[C@@H](C(N1c2ccccc2)=Cc2cccc(C(N(C)C)=O)c2C1=O)Nc1ncnc2c1nc[s]2 Chemical compound C[C@@H](C(N1c2ccccc2)=Cc2cccc(C(N(C)C)=O)c2C1=O)Nc1ncnc2c1nc[s]2 GXRZDBJZLNTOBK-HNNXBMFYSA-N 0.000 description 1
- FHBSMPJTDAXBLY-AWEZNQCLSA-N C[C@@H](C(N1c2ccccc2)=Cc2cccc(C(NC)=O)c2C1=O)Nc1ncnc2c1nc[s]2 Chemical compound C[C@@H](C(N1c2ccccc2)=Cc2cccc(C(NC)=O)c2C1=O)Nc1ncnc2c1nc[s]2 FHBSMPJTDAXBLY-AWEZNQCLSA-N 0.000 description 1
- JJENTNMKUKLDOG-ZDUSSCGKSA-N C[C@@H](C(N1c2ccccc2)=Cc2cccc(C(O)=O)c2C1=O)Nc1ncnc2c1nc[s]2 Chemical compound C[C@@H](C(N1c2ccccc2)=Cc2cccc(C(O)=O)c2C1=O)Nc1ncnc2c1nc[s]2 JJENTNMKUKLDOG-ZDUSSCGKSA-N 0.000 description 1
- AYGDAOSWVIBGMS-AWEZNQCLSA-N C[C@@H](C(N1c2ccccc2)=Cc2cccc(C=O)c2C1=O)Nc1ncnc2c1nc[s]2 Chemical compound C[C@@H](C(N1c2ccccc2)=Cc2cccc(C=O)c2C1=O)Nc1ncnc2c1nc[s]2 AYGDAOSWVIBGMS-AWEZNQCLSA-N 0.000 description 1
- NBUHTTJGQKIBMR-UHFFFAOYSA-N Cc1ncnc(C)c1N Chemical compound Cc1ncnc(C)c1N NBUHTTJGQKIBMR-UHFFFAOYSA-N 0.000 description 1
- UDWASTTYRXVNSS-UHFFFAOYSA-N Cc1ncnc(C)c1[N+]([O-])=O Chemical compound Cc1ncnc(C)c1[N+]([O-])=O UDWASTTYRXVNSS-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161509441P | 2011-07-19 | 2011-07-19 | |
| US61/509,441 | 2011-07-19 | ||
| US201261622251P | 2012-04-10 | 2012-04-10 | |
| US61/622,251 | 2012-04-10 | ||
| PCT/US2012/047190 WO2013012918A1 (en) | 2011-07-19 | 2012-07-18 | Heterocyclic compounds and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014520888A JP2014520888A (ja) | 2014-08-25 |
| JP2014520888A5 JP2014520888A5 (enExample) | 2015-09-10 |
| JP6027611B2 true JP6027611B2 (ja) | 2016-11-16 |
Family
ID=46598988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014521731A Expired - Fee Related JP6027611B2 (ja) | 2011-07-19 | 2012-07-18 | 複素環式化合物及びその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9056877B2 (enExample) |
| EP (1) | EP2734530A1 (enExample) |
| JP (1) | JP6027611B2 (enExample) |
| KR (1) | KR20140063605A (enExample) |
| CN (1) | CN103946226A (enExample) |
| AR (1) | AR088218A1 (enExample) |
| AU (1) | AU2012284091B2 (enExample) |
| CA (1) | CA2842190A1 (enExample) |
| HK (1) | HK1198475A1 (enExample) |
| IL (1) | IL230536A0 (enExample) |
| MX (1) | MX2014000648A (enExample) |
| TW (1) | TWI565709B (enExample) |
| WO (1) | WO2013012918A1 (enExample) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2260874A1 (en) * | 2003-01-06 | 2010-12-15 | Angiochem Inc. | Aprotinin analogs as carriers across the blood-brain barrier |
| DK1993360T3 (en) | 2005-12-28 | 2017-05-22 | Vertex Pharma | SOLID FORMS OF N- [2,4-BIS (1,1-DIMETHYLETHYL) -5-HYDROXYPHENYL] -1,4-DIHYDRO-4-OXOQUINOLIN-3-CARBOXAMIDE |
| US9365634B2 (en) * | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
| CN101965335B (zh) | 2008-01-04 | 2015-01-14 | 英特利凯恩有限责任公司 | 某些化学实体、组合物和方法 |
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| PL2279008T3 (pl) | 2008-04-18 | 2020-03-31 | Angiochem Inc. | Kompozycje farmaceutyczne paklitakselu, analogów paklitakselu lub koniugatów paklitakselu oraz powiązane sposoby wytwarzania i zastosowanie |
| EP2346508B1 (en) | 2008-09-26 | 2016-08-24 | Intellikine, LLC | Heterocyclic kinase inhibitors |
| MX2011004017A (es) | 2008-10-15 | 2011-06-24 | Angiochem Inc | Conjugados de agonistas glp-1 y usos de los mismos. |
| EP2346896A4 (en) | 2008-10-15 | 2014-06-25 | Angiochem Inc | ETOPOSID AND DOXORUBICIN CONJUGATES FOR ACTIVITY EXTRACTION |
| BRPI0922689A2 (pt) | 2008-12-05 | 2018-11-06 | Angiochem Inc. | conjugados de neurotensina ou análogos de neurotensina e usos dos mesmos |
| AU2009327267A1 (en) | 2008-12-17 | 2011-07-14 | Angiochem, Inc. | Membrane type-1 matrix metalloprotein inhibitors and uses thereof |
| EP2421562B1 (en) | 2009-04-20 | 2019-03-13 | Angiochem Inc. | Treatment of ovarian cancer using an anticancer agent conjugated to an angiopep-2 analog |
| WO2010129816A2 (en) | 2009-05-07 | 2010-11-11 | Intellikine, Inc. | Heterocyclic compounds and uses thereof |
| CA2766537A1 (en) | 2009-07-02 | 2011-01-06 | Angiochem Inc. | Multimeric peptide conjugates and uses thereof |
| ES2593256T3 (es) | 2010-05-21 | 2016-12-07 | Infinity Pharmaceuticals, Inc. | Compuestos químicos, composiciones y métodos para las modulaciones de cinasas |
| MX342405B (es) | 2010-06-03 | 2016-09-28 | Pharmacyclics Inc | El uso de inhibidores de la tirosina quinasa de bruton (btk). |
| AU2011326427B2 (en) | 2010-11-10 | 2016-01-07 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
| EP2663309B1 (en) | 2011-01-10 | 2017-03-15 | Infinity Pharmaceuticals, Inc. | Processes for preparing isoquinolinones and solid forms of isoquinolinones |
| EP2481500A1 (de) | 2011-01-31 | 2012-08-01 | Stopinc Aktiengesellschaft | Verschlussplatte sowie ein Schiebenverschluss am Ausguss eines Metallschmelze enthaltenden Behälters |
| HK1198475A1 (en) | 2011-07-19 | 2015-05-08 | 无限药品股份有限公司 | Heterocyclic compounds and uses thereof |
| EP2734520B1 (en) | 2011-07-19 | 2016-09-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| US8785470B2 (en) | 2011-08-29 | 2014-07-22 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
| CN104704129A (zh) | 2012-07-24 | 2015-06-10 | 药品循环公司 | 与对布鲁顿酪氨酸激酶(btk)抑制剂的抗性相关的突变 |
| LT2914296T (lt) | 2012-11-01 | 2018-09-25 | Infinity Pharmaceuticals, Inc. | Vėžio gydymas, panaudojant p13 kinazės izoformos moduliatorius |
| CN104870017B (zh) | 2012-11-08 | 2020-08-14 | 理森制药股份公司 | 含有PDE4抑制剂和PI3δ或双重PI3δ-γ激酶抑制剂的药物组合物 |
| US9481667B2 (en) | 2013-03-15 | 2016-11-01 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
| SG11201509842SA (en) | 2013-05-30 | 2015-12-30 | Infinity Pharmaceuticals Inc | Treatment of cancers using pi3 kinase isoform modulators |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| RU2675105C9 (ru) | 2013-09-22 | 2019-01-09 | Саншайн Лейк Фарма Ко., Лтд. | Замещенные аминопиримидиновые соединения и способы их использования |
| WO2015051241A1 (en) | 2013-10-04 | 2015-04-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| PH12016500582B1 (en) | 2013-10-04 | 2023-06-30 | Infinity Pharmaceuticals Inc | Heterocyclic compounds and uses thereof |
| EP3076974A1 (en) | 2013-12-05 | 2016-10-12 | Acerta Pharma B.V. | Therapeutic combination of a pi3k inhibitor and a btk inhibitor |
| AR098776A1 (es) * | 2013-12-18 | 2016-06-15 | Chiesi Farm Spa | Derivados del isocromeno como inhibidores de las fosfoinositido-3 quinasas |
| JP6701088B2 (ja) * | 2014-03-19 | 2020-05-27 | インフィニティー ファーマシューティカルズ， インコーポレイテッド | Ｐｉ３ｋ−ガンマ媒介障害の治療で使用するための複素環式化合物 |
| JP2017509336A (ja) | 2014-03-20 | 2017-04-06 | ファーマサイクリックス エルエルシー | ホスホリパーゼｃガンマ２及び耐性に関連した変異 |
| UY36060A (es) | 2014-04-02 | 2015-10-30 | Bayer Pharma AG | Compuestos de azol sustituidos con amida |
| WO2015160975A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| PE20170640A1 (es) | 2014-07-04 | 2017-05-26 | Lupin Ltd | Derivados de quinolizinona como inhibidores de pi3k |
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| HK1198475A1 (en) | 2015-05-08 |
| US9056877B2 (en) | 2015-06-16 |
| WO2013012918A1 (en) | 2013-01-24 |
| JP2014520888A (ja) | 2014-08-25 |
| AR088218A1 (es) | 2014-05-21 |
| CA2842190A1 (en) | 2013-01-24 |
| US20130029984A1 (en) | 2013-01-31 |
| TW201311700A (zh) | 2013-03-16 |
| EP2734530A1 (en) | 2014-05-28 |
| CN103946226A (zh) | 2014-07-23 |
| KR20140063605A (ko) | 2014-05-27 |
| AU2012284091B2 (en) | 2015-11-12 |
| US20150246932A1 (en) | 2015-09-03 |
| AU2012284091A1 (en) | 2013-03-21 |
| US9605003B2 (en) | 2017-03-28 |
| MX2014000648A (es) | 2014-09-25 |
| IL230536A0 (en) | 2014-03-31 |
| TWI565709B (zh) | 2017-01-11 |
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