JP5814505B2 - antimiRNAアンチセンスオリゴヌクレオチドを含む医薬組成物 - Google Patents
antimiRNAアンチセンスオリゴヌクレオチドを含む医薬組成物 Download PDFInfo
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- JP5814505B2 JP5814505B2 JP2009503411A JP2009503411A JP5814505B2 JP 5814505 B2 JP5814505 B2 JP 5814505B2 JP 2009503411 A JP2009503411 A JP 2009503411A JP 2009503411 A JP2009503411 A JP 2009503411A JP 5814505 B2 JP5814505 B2 JP 5814505B2
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/02—Immunomodulators
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Reproductive Health (AREA)
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78899506P | 2006-04-03 | 2006-04-03 | |
| US60/788,995 | 2006-04-03 | ||
| DKPA200600478 | 2006-04-03 | ||
| DKPA200600478 | 2006-04-03 | ||
| US79681306P | 2006-05-01 | 2006-05-01 | |
| US60/796,813 | 2006-05-01 | ||
| DKPA200600615 | 2006-05-01 | ||
| DKPA200600615 | 2006-05-01 | ||
| US83871006P | 2006-08-18 | 2006-08-18 | |
| US60/838,710 | 2006-08-18 | ||
| DKPA200601401 | 2006-10-30 | ||
| DKPA200601401 | 2006-10-30 | ||
| PCT/DK2007/000169 WO2007112754A2 (en) | 2006-04-03 | 2007-03-30 | Pharmaceutical compositions comprising anti-mirna antisense oligonucleotides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014022650A Division JP5872603B2 (ja) | 2006-04-03 | 2014-02-07 | antimiRNAアンチセンスオリゴヌクレオチドを含む医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009532392A JP2009532392A (ja) | 2009-09-10 |
| JP2009532392A5 JP2009532392A5 (enExample) | 2010-05-13 |
| JP5814505B2 true JP5814505B2 (ja) | 2015-11-17 |
Family
ID=38564007
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009503411A Expired - Fee Related JP5814505B2 (ja) | 2006-04-03 | 2007-03-30 | antimiRNAアンチセンスオリゴヌクレオチドを含む医薬組成物 |
| JP2009503410A Expired - Fee Related JP5198430B2 (ja) | 2006-04-03 | 2007-03-30 | antimiRNAアンチセンスオリゴヌクレオチドを含む医薬組成物 |
| JP2012242996A Pending JP2013078317A (ja) | 2006-04-03 | 2012-11-02 | antimiRNAアンチセンスオリゴヌクレオチドを含む医薬組成物 |
| JP2014022650A Expired - Fee Related JP5872603B2 (ja) | 2006-04-03 | 2014-02-07 | antimiRNAアンチセンスオリゴヌクレオチドを含む医薬組成物 |
| JP2015221396A Expired - Fee Related JP6326025B2 (ja) | 2006-04-03 | 2015-11-11 | antimiRNAアンチセンスオリゴヌクレオチドを含む医薬組成物 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009503410A Expired - Fee Related JP5198430B2 (ja) | 2006-04-03 | 2007-03-30 | antimiRNAアンチセンスオリゴヌクレオチドを含む医薬組成物 |
| JP2012242996A Pending JP2013078317A (ja) | 2006-04-03 | 2012-11-02 | antimiRNAアンチセンスオリゴヌクレオチドを含む医薬組成物 |
| JP2014022650A Expired - Fee Related JP5872603B2 (ja) | 2006-04-03 | 2014-02-07 | antimiRNAアンチセンスオリゴヌクレオチドを含む医薬組成物 |
| JP2015221396A Expired - Fee Related JP6326025B2 (ja) | 2006-04-03 | 2015-11-11 | antimiRNAアンチセンスオリゴヌクレオチドを含む医薬組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (8) | US20100004320A1 (enExample) |
| EP (3) | EP2007889A2 (enExample) |
| JP (5) | JP5814505B2 (enExample) |
| KR (1) | KR101407707B1 (enExample) |
| AU (1) | AU2007234191B2 (enExample) |
| CA (4) | CA3042781C (enExample) |
| DK (1) | DK2666859T3 (enExample) |
| EA (1) | EA015570B1 (enExample) |
| ES (1) | ES2715625T3 (enExample) |
| IL (1) | IL194007A0 (enExample) |
| MX (1) | MX2008012219A (enExample) |
| WO (2) | WO2007112754A2 (enExample) |
Families Citing this family (272)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005013901A2 (en) | 2003-07-31 | 2005-02-17 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and compositions for use in modulation of small non-coding rnas |
| PT1747023E (pt) | 2004-05-04 | 2011-04-11 | Univ Leland Stanford Junior | Métodos e composições para reduzir quantidades de genoma viral numa célula alvo |
| US8592384B2 (en) | 2005-04-04 | 2013-11-26 | The Board Of Regents Of The University Of Texas System | Micro-RNA's that regulate muscle cells |
| WO2007016548A2 (en) | 2005-08-01 | 2007-02-08 | The Ohio State University Research Foundation | Micro-rna-based methods and compositions for the diagnosis, prognosis and treatment of breast cancer |
| ATE494372T1 (de) | 2005-08-29 | 2011-01-15 | Regulus Therapeutics Inc | Verfahren für mir-122a-modulation |
| US8481505B2 (en) | 2005-09-12 | 2013-07-09 | The Ohio State University Research Foundation | Compositions and methods for the diagnosis and therapy of BCL2-associated cancers |
| WO2007081680A2 (en) | 2006-01-05 | 2007-07-19 | The Ohio State University Research Foundation | Microrna expression abnormalities in pancreatic endocrine and acinar tumors |
| EP2484782B1 (en) | 2006-01-05 | 2015-11-18 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis and treatment of solid cancers |
| AU2007205234B2 (en) | 2006-01-05 | 2012-07-12 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer |
| ES2446362T3 (es) | 2006-03-20 | 2014-03-07 | The Ohio State University Research Foundation | Huellas de microARN durante megacariocipoyesis humana |
| CA3042781C (en) | 2006-04-03 | 2021-10-19 | Roche Innovation Center Copenhagen A/S | Pharmaceutical composition comprising anti-mirna antisense oligonucleotides |
| EA201100811A1 (ru) | 2006-04-03 | 2012-06-29 | Сантарис Фарма А/С | Фармацевтическая композиция |
| EP2505646A1 (en) | 2006-05-05 | 2012-10-03 | Isis Pharmaceuticals, Inc. | Compounds and methods for modulating expression of CRP |
| ES2425387T3 (es) | 2006-07-13 | 2013-10-15 | The Ohio State University Research Foundation | Mir-106a para diagnosticar adenocarcinoma de colon de pronóstico de supervivencia pobre |
| DK2056882T3 (da) | 2006-08-01 | 2012-11-19 | Univ Texas | Identifikation af en mikro-rna, som aktiverer ekspression af en tung kæde med beta-myosin |
| EP2090665A2 (en) | 2006-10-20 | 2009-08-19 | Exiqon A/S | Novel human microRNAs associated with cancer |
| US8188255B2 (en) | 2006-10-20 | 2012-05-29 | Exiqon A/S | Human microRNAs associated with cancer |
| AU2007323469B2 (en) | 2006-11-23 | 2014-07-24 | Guangdong Maijinjia Biotechnology Co., Ltd | Oligonucleotides for modulating target RNA activity |
| JP2010516291A (ja) | 2007-01-31 | 2010-05-20 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 急性骨髄性白血病(aml)の診断、予後及び治療のためのマイクロrnaに基づく方法及び組成物 |
| US8580756B2 (en) | 2007-03-22 | 2013-11-12 | Santaris Pharma A/S | Short oligomer antagonist compounds for the modulation of target mRNA |
| US8470791B2 (en) | 2007-03-22 | 2013-06-25 | Santaris Pharma A/S | RNA antagonist compounds for the inhibition of Apo-B100 expression |
| WO2008116267A1 (en) * | 2007-03-26 | 2008-10-02 | Crc For Asthma And Airways Ltd | Therapeutic targets and molecules |
| CN101827941B (zh) * | 2007-04-30 | 2014-07-16 | 俄亥俄州立大学研究基金会 | 用于区分胰腺癌与正常胰腺功能和/或慢性胰腺炎的方法 |
| CA2690643A1 (en) | 2007-06-14 | 2008-12-18 | Mirx Therapeutics Aps | Oligonucleotides for modulation of target rna activity |
| US8053186B2 (en) | 2007-06-15 | 2011-11-08 | The Ohio State University Research Foundation | Oncogenic ALL-1 fusion proteins for targeting Drosha-mediated microRNA processing |
| DK2182969T3 (en) | 2007-07-31 | 2017-02-27 | Univ Texas | Micro-RNA family that modulates fibrosis and its applications |
| CA2694928A1 (en) * | 2007-07-31 | 2009-02-05 | Board Of Regents, The University Of Texas System | Micro-rnas that control myosin expression and myofiber identity |
| EP2173911B1 (en) | 2007-07-31 | 2014-06-18 | The Ohio State University Research Foundation | Methods for reverting methylation by targeting dnmt3a and dnmt3b |
| EP2653561B1 (en) | 2007-08-03 | 2016-03-02 | The Ohio State University Research Foundation | Ultraconserved regions encoding ncRNAs |
| EP3028708A1 (en) | 2007-08-22 | 2016-06-08 | The Ohio State University Research Foundation | Methods and compositions for inducing deregulation of epha7 and erk phosphorylation in human acute leukemias |
| DK2205737T3 (da) * | 2007-10-04 | 2013-05-21 | Santaris Pharma As | Mikromirer |
| AU2013273821B2 (en) * | 2007-10-04 | 2016-03-10 | Roche Innovation Center Copenhagen A/S | Micromirs |
| EP2212440A4 (en) * | 2007-10-11 | 2011-04-06 | Univ Ohio State Res Found | METHOD AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF ADENOCARCINOMES OF DISHES |
| WO2009055773A2 (en) | 2007-10-26 | 2009-04-30 | The Ohio State University Research Foundation | Methods for identifying fragile histidine triad (fhit) interaction and uses thereof |
| CN101980712B (zh) * | 2007-10-29 | 2015-02-18 | 雷古拉斯治疗公司 | 用于肝癌治疗的靶向微小rna |
| WO2009062169A2 (en) | 2007-11-09 | 2009-05-14 | The Board Of Regents Of The University Of Texas System | Micro-rnas of the mir-15 family modulate cardiomyocyte survival and cardiac repair |
| GB0802754D0 (en) * | 2008-02-14 | 2008-03-26 | Inst Superiore Di Sanito | Antisense RNA targetting CXCR4 |
| CN102083980A (zh) * | 2008-02-21 | 2011-06-01 | 得克萨斯系统大学董事会 | 调节平滑肌增殖和分化的微小rna及其用途 |
| EP2096171A1 (en) | 2008-02-27 | 2009-09-02 | Julius-Maximilians-Universität Würzburg | MicroRNA (miRNA) and down-stream targets for diagnostic and therapeutic purposes |
| JP5662166B2 (ja) * | 2008-02-28 | 2015-01-28 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイションThe Ohio State University Research Foundation | 胃癌の診断、予後診断及び治療のためのマイクロrnaに基づいた方法及び組成物 |
| EP2268811A1 (en) | 2008-03-07 | 2011-01-05 | Santaris Pharma A/S | Pharmaceutical compositions for treatment of microrna related diseases |
| WO2009117418A2 (en) | 2008-03-17 | 2009-09-24 | The Board Of Regents Of The University Of Texas System | Identification of micro-rnas involved in neuromuscular synapse maintenance and regeneration |
| EP2105145A1 (en) | 2008-03-27 | 2009-09-30 | ETH Zürich | Method for muscle-specific delivery lipid-conjugated oligonucleotides |
| EP2281903B1 (en) | 2008-04-30 | 2017-01-04 | NEC Corporation | METHOD FOR EVALUATION OF CANCER BY USING miRNA CANCER MARKER |
| WO2009152300A1 (en) | 2008-06-11 | 2009-12-17 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Use of mir-26 family as a predictive marker of hepatocellular carcinoma and responsiveness to therapy |
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