KR101407707B1 - Anti-mirna 안티센스 올리고뉴클레오타이드를 함유하는 약학적 조성물 - Google Patents
Anti-mirna 안티센스 올리고뉴클레오타이드를 함유하는 약학적 조성물 Download PDFInfo
- Publication number
- KR101407707B1 KR101407707B1 KR20087026963A KR20087026963A KR101407707B1 KR 101407707 B1 KR101407707 B1 KR 101407707B1 KR 20087026963 A KR20087026963 A KR 20087026963A KR 20087026963 A KR20087026963 A KR 20087026963A KR 101407707 B1 KR101407707 B1 KR 101407707B1
- Authority
- KR
- South Korea
- Prior art keywords
- oligonucleotide
- lna
- delete delete
- units
- dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Obesity (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78899506P | 2006-04-03 | 2006-04-03 | |
| DKPA200600478 | 2006-04-03 | ||
| DKPA200600478 | 2006-04-03 | ||
| US60/788,995 | 2006-04-03 | ||
| US79681306P | 2006-05-01 | 2006-05-01 | |
| DKPA200600615 | 2006-05-01 | ||
| US60/796,813 | 2006-05-01 | ||
| DKPA200600615 | 2006-05-01 | ||
| US83871006P | 2006-08-18 | 2006-08-18 | |
| US60/838,710 | 2006-08-18 | ||
| DKPA200601401 | 2006-10-30 | ||
| DKPA200601401 | 2006-10-30 | ||
| PCT/DK2007/000168 WO2007112753A2 (en) | 2006-04-03 | 2007-03-30 | Pharmaceutical composition comprising anti-mirna antisense oligonucleotides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20080108154A KR20080108154A (ko) | 2008-12-11 |
| KR101407707B1 true KR101407707B1 (ko) | 2014-06-19 |
Family
ID=38564007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR20087026963A Expired - Fee Related KR101407707B1 (ko) | 2006-04-03 | 2007-03-30 | Anti-mirna 안티센스 올리고뉴클레오타이드를 함유하는 약학적 조성물 |
Country Status (12)
| Country | Link |
|---|---|
| US (8) | US20100004320A1 (enExample) |
| EP (3) | EP2194129A3 (enExample) |
| JP (5) | JP5198430B2 (enExample) |
| KR (1) | KR101407707B1 (enExample) |
| AU (1) | AU2007234191B2 (enExample) |
| CA (4) | CA3024953A1 (enExample) |
| DK (1) | DK2666859T3 (enExample) |
| EA (1) | EA015570B1 (enExample) |
| ES (1) | ES2715625T3 (enExample) |
| IL (1) | IL194007A0 (enExample) |
| MX (1) | MX2008012219A (enExample) |
| WO (2) | WO2007112753A2 (enExample) |
Families Citing this family (261)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1648914A4 (en) | 2003-07-31 | 2009-12-16 | Regulus Therapeutics Inc | OLIGOMERIC COMPOUNDS AND COMPOSITIONS USEFUL FOR MODULATING SMALL NON-CODING RNA |
| CA2564503C (en) | 2004-05-04 | 2015-12-29 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of mir-122 in hepatitis c virus infected subjects and cells |
| CA2603881A1 (en) | 2005-04-04 | 2006-10-12 | The Board Of Regents Of The University Of Texas System | Micro-rna's that regulate muscle cells |
| JP5489459B2 (ja) | 2005-08-01 | 2014-05-14 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 乳癌の診断、予後及び治療のためのマイクロrnaに基づいた方法及び組成物 |
| EP2338991B1 (en) | 2005-08-29 | 2017-01-18 | Regulus Therapeutics Inc. | Methods for use in modulating MIR-122a |
| CN101296702B (zh) | 2005-09-12 | 2012-11-28 | 俄亥俄州立大学研究基金会 | 用于诊断或治疗bcl2相关癌症的组合物和方法 |
| ES2553442T3 (es) | 2006-01-05 | 2015-12-09 | The Ohio State University Research Foundation | Procedimientos basados en los microARN para el diagnóstico, pronóstico y tratamiento del cáncer de pulmón |
| ES2536423T3 (es) | 2006-01-05 | 2015-05-25 | The Ohio State University Research Foundation | Métodos basados en microARN para el diagnóstico de cáncer de próstata |
| WO2007081680A2 (en) | 2006-01-05 | 2007-07-19 | The Ohio State University Research Foundation | Microrna expression abnormalities in pancreatic endocrine and acinar tumors |
| EP2369012A1 (en) | 2006-03-20 | 2011-09-28 | The Ohio State University Research Foundation | Micro-RNA fingerprints during human megakaryocytopoiesis |
| CA3024953A1 (en) | 2006-04-03 | 2007-10-11 | Roche Innovation Center Copenhagen A/S | Pharmaceutical composition comprising anti-mirna antisense oligonucleotides |
| PL2666859T3 (pl) * | 2006-04-03 | 2019-09-30 | Roche Innovation Center Copenhagen A/S | Kompozycja farmaceutyczna zawierająca antysensowne oligonukleotydy anty-miRNA |
| EP2505646A1 (en) | 2006-05-05 | 2012-10-03 | Isis Pharmaceuticals, Inc. | Compounds and methods for modulating expression of CRP |
| ES2442890T3 (es) | 2006-07-13 | 2014-02-14 | The Ohio State University Research Foundation | Métodos y composiciones basados en micro-ARN para el diagnóstico y el tratamiento de enfermedades relacionadas con el colon |
| MX2009001281A (es) | 2006-08-01 | 2009-04-16 | Univ Texas | Identificacion de un micro-arn que activa la expresion de la cadena pesada de beta-miosina. |
| US8188255B2 (en) | 2006-10-20 | 2012-05-29 | Exiqon A/S | Human microRNAs associated with cancer |
| WO2008046911A2 (en) | 2006-10-20 | 2008-04-24 | Exiqon A/S | Novel human micrornas associated with cancer |
| US20100021914A1 (en) | 2006-11-23 | 2010-01-28 | Querdenker Aps | Oligonucleotides for modulating target rna activity |
| CN105256004A (zh) | 2007-01-31 | 2016-01-20 | 俄亥俄州立大学研究基金会 | 用于急性髓细胞白血病(aml)的诊断、预后和治疗的基于微rna的方法和组合物 |
| WO2008113830A1 (en) | 2007-03-22 | 2008-09-25 | Santaris Pharma A/S | Rna antagonist compounds for the inhibition of apo-b100 expression |
| DK2149605T3 (da) | 2007-03-22 | 2013-09-30 | Santaris Pharma As | Korte RNA antagonist forbindelser til modulering af det ønskede mRNA |
| WO2008116267A1 (en) * | 2007-03-26 | 2008-10-02 | Crc For Asthma And Airways Ltd | Therapeutic targets and molecules |
| EP2142659A4 (en) * | 2007-04-30 | 2010-06-09 | Univ Ohio State Res Found | METHOD FOR THE DISTINCTION OF PANCREATIC CANCER OF NORMAL IMMERSION SPECTRUM FUNCTIONS AND CHRONIC IMMERSION IMAGING IGNITION |
| CN101821390A (zh) | 2007-06-14 | 2010-09-01 | 米尔克斯治疗有限责任公司 | 用于调节靶rna活性的寡核苷酸 |
| CN101918424A (zh) | 2007-06-15 | 2010-12-15 | 俄亥俄州立大学研究基金会 | 用于靶向由Drosha介导的微小RNA加工的致癌ALL-1融合蛋白 |
| ES2621161T3 (es) | 2007-07-31 | 2017-07-03 | The Board Of Regents Of The University Of Texas System | Familia de micro-ARN que modula la fibrosis y usos de la misma |
| CA2694928A1 (en) | 2007-07-31 | 2009-02-05 | Board Of Regents, The University Of Texas System | Micro-rnas that control myosin expression and myofiber identity |
| JP2010535782A (ja) | 2007-07-31 | 2010-11-25 | ズィ、オハイオウ、ステイト、ユーニヴァーサティ、リサーチ、ファウンデイシャン | Dnmt3a及びdnmt3bを標的にすることによるメチル化を元に戻す方法 |
| ES2562077T3 (es) | 2007-08-03 | 2016-03-02 | The Ohio State University Research Foundation | Regiones ultraconservadas que codifican ARNnc |
| EP2183593B1 (en) | 2007-08-22 | 2016-01-13 | The Ohio State University Research Foundation | Methods and compositions for inducing deregulation of epha7 and erk phosphorylation in human acute leukemias |
| KR101889518B1 (ko) | 2007-10-04 | 2018-08-17 | 로슈 이노베이션 센터 코펜하겐 에이/에스 | 마이크로MIRs |
| AU2013273821B2 (en) * | 2007-10-04 | 2016-03-10 | Roche Innovation Center Copenhagen A/S | Micromirs |
| AU2008310704B2 (en) * | 2007-10-11 | 2014-03-20 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Methods and compositions for the diagnosis and treatment of esphageal adenocarcinomas |
| EP2201112A4 (en) | 2007-10-26 | 2011-02-02 | Univ Ohio State Res Found | METHOD FOR IDENTIFYING FHIT INTERACTION AND USE |
| WO2009058907A2 (en) * | 2007-10-29 | 2009-05-07 | Isis Pharmaceuticals, Inc. | Targeting micrornas for the treatment of liver cancer |
| CN101951924B (zh) * | 2007-11-09 | 2015-06-24 | 得克萨斯系统大学董事会 | Mir-15家族的微小rna调控心肌细胞存活和心脏修复 |
| GB0802754D0 (en) * | 2008-02-14 | 2008-03-26 | Inst Superiore Di Sanito | Antisense RNA targetting CXCR4 |
| WO2009105759A2 (en) * | 2008-02-21 | 2009-08-27 | The Board Of Regents Of The University Of Texas System | Micro-rnas that modulate smooth muscle proliferation and differentiation and uses thereof |
| EP2096171A1 (en) | 2008-02-27 | 2009-09-02 | Julius-Maximilians-Universität Würzburg | MicroRNA (miRNA) and down-stream targets for diagnostic and therapeutic purposes |
| US20110034538A1 (en) * | 2008-02-28 | 2011-02-10 | The Ohio State University Research Foundation | MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Gastric Cancer |
| WO2009109665A1 (en) * | 2008-03-07 | 2009-09-11 | Santaris Pharma A/S | Pharmaceutical compositions for treatment of microrna related diseases |
| WO2009117418A2 (en) | 2008-03-17 | 2009-09-24 | The Board Of Regents Of The University Of Texas System | Identification of micro-rnas involved in neuromuscular synapse maintenance and regeneration |
| EP2105145A1 (en) * | 2008-03-27 | 2009-09-30 | ETH Zürich | Method for muscle-specific delivery lipid-conjugated oligonucleotides |
| EP2281903B1 (en) | 2008-04-30 | 2017-01-04 | NEC Corporation | METHOD FOR EVALUATION OF CANCER BY USING miRNA CANCER MARKER |
| US9125923B2 (en) | 2008-06-11 | 2015-09-08 | The Ohio State University | Use of MiR-26 family as a predictive marker for hepatocellular carcinoma and responsiveness to therapy |
| WO2010005295A1 (en) * | 2008-06-16 | 2010-01-14 | Koninklijke Nederlandse Akademie Van Wetenschappen | Means and methods for counteracting, delaying and/or preventing heart disease |
| ES2398500T3 (es) | 2008-06-27 | 2013-03-19 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute For Biomedical Research | Predicción de respuesta a terapia antiviral |
| EP2315832B1 (en) * | 2008-08-01 | 2015-04-08 | Roche Innovation Center Copenhagen A/S | Micro-rna mediated modulation of colony stimulating factors |
| EP2191834A1 (en) * | 2008-11-26 | 2010-06-02 | Centre National De La Recherche Scientifique (Cnrs) | Compositions and methods for treating retrovirus infections |
| WO2010065792A2 (en) * | 2008-12-04 | 2010-06-10 | Curna, Inc. | Treatment of erythropoietin (epo) related diseases by inhibition of natural antisense transcript to epo |
| WO2010076248A1 (en) | 2008-12-31 | 2010-07-08 | Santaris Pharma A/S | Use of lna apob antisense oligomers for the treatment of acute coronary syndromes |
| JP5943608B2 (ja) | 2009-02-04 | 2016-07-05 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | 心臓障害の治療におけるmir−208およびmir−499の二重ターゲティング |
| EP2218458A1 (en) * | 2009-02-13 | 2010-08-18 | Fondazione Telethon | Molecules able to modulate the expression of at least a gene involved in degradative pathways and uses thereof |
| WO2010117829A2 (en) | 2009-03-31 | 2010-10-14 | The United States Of America As Represented By The Secretary Department Of Health And Human Services | Differentially expressed micrornas as biomarkers for the diagnosis and treatment of sjögren's syndrome |
| JP5773535B2 (ja) * | 2009-04-24 | 2015-09-02 | ロシュ・イノベーション・センター・コペンハーゲン・アクティーゼルスカブRoche Innovation Center Copenhagen A/S | インターフェロンに非応答性のhcv患者の治療のための医薬組成物 |
| WO2010133970A1 (en) | 2009-05-20 | 2010-11-25 | Eth Zurich | Targeting micrornas for metabolic disorders |
| WO2010135714A2 (en) * | 2009-05-22 | 2010-11-25 | The Methodist Hospital Research Institute | Methods for modulating adipocyte expression using microrna compositions |
| US8563528B2 (en) | 2009-07-21 | 2013-10-22 | Santaris Pharma A/S | Antisense oligomers targeting PCSK9 |
| US20110190372A1 (en) * | 2009-08-07 | 2011-08-04 | New York University | Compositions and methods for treating inflammatory disorders |
| WO2011022316A1 (en) * | 2009-08-20 | 2011-02-24 | The Regents Of The University Of Colorado, A Body Corporate | Mirnas dysregulated in triple-negative breast cancer |
| CN102002493B (zh) * | 2009-09-01 | 2013-04-10 | 中国科学院上海生命科学研究院 | 小rna-326制备药物的应用 |
| WO2011032100A1 (en) * | 2009-09-11 | 2011-03-17 | Government Of The U.S.A., As Represented By The Secretary, Department Of Health And Human Services | Inhibitors of kshv vil6 and human il6 |
| US8975019B2 (en) * | 2009-10-19 | 2015-03-10 | University Of Massachusetts | Deducing exon connectivity by RNA-templated DNA ligation/sequencing |
| WO2011048125A1 (en) | 2009-10-20 | 2011-04-28 | Santaris Pharma A/S | Oral delivery of therapeutically effective lna oligonucleotides |
| US8916533B2 (en) | 2009-11-23 | 2014-12-23 | The Ohio State University | Materials and methods useful for affecting tumor cell growth, migration and invasion |
| WO2011069100A2 (en) | 2009-12-04 | 2011-06-09 | Duke University | Microrna and use thereof in identification of b cell malignancies |
| US9340782B2 (en) | 2010-01-20 | 2016-05-17 | Board Of Regents, The University Of Texas System | Antimir-451 for the treatment of polycythemias |
| WO2011111715A1 (ja) * | 2010-03-09 | 2011-09-15 | 協和発酵キリン株式会社 | 細胞周期を制御する核酸 |
| ES2743600T3 (es) | 2010-03-12 | 2020-02-20 | Brigham & Womens Hospital Inc | Métodos de tratamiento de los trastornos inflamatorios vasculares |
| US20130079505A1 (en) * | 2010-03-24 | 2013-03-28 | Mirrx Therapeutics A/S | Bivalent antisense oligonucleotides |
| US20130079384A1 (en) * | 2010-04-21 | 2013-03-28 | Academisch Medisch Centrum Bij De Universiteit Van Amsterdam | Means and Methods for Determining Risk of Cardiovascular Disease |
| EP2563935B1 (en) * | 2010-04-30 | 2014-04-16 | Exiqon A/S | In situ hybridization method and buffer. |
| US20110281933A1 (en) * | 2010-05-13 | 2011-11-17 | Saint Louis University | Methods and compositions for the management of cardiovascular disease with oligonucleotides |
| FR2960130B1 (fr) | 2010-05-21 | 2013-11-01 | Dominique Cingotti | Agent edulcorant contenant un extrait de stevia rebaudiana bertoni |
| JP5894581B2 (ja) * | 2010-05-21 | 2016-03-30 | ウニヴェルズィテート・フューア・ボーデンクルトゥーア・ウィーン | 骨障害及び/又は心血管障害の治療又は診断に使用する組成物 |
| US20130210883A1 (en) | 2010-05-21 | 2013-08-15 | Johannes Grillari | Lipase inhibitors |
| CA2801342A1 (en) * | 2010-06-04 | 2011-12-08 | Eric N. Olson | Regulation of metabolism by mir-378 |
| US20130150256A1 (en) | 2010-06-11 | 2013-06-13 | Jane Synnergren | Novel micrornas for the detection and isolation of human embryonic stem cell-derived cardiac cell types |
| CN103189511B (zh) | 2010-07-12 | 2016-10-12 | 国立大学法人鸟取大学 | 利用siRNA导入的新型hiPSC制作法 |
| WO2012012716A2 (en) | 2010-07-23 | 2012-01-26 | Regulus Therapeutics, Inc. | Targeting micrornas for the treatment of fibrosis |
| EP2608812B1 (en) | 2010-08-25 | 2018-08-15 | The General Hospital Corporation | Nucleic acids targeting mir-33 micrornas for regulating lipid metabolism |
| AU2011293195A1 (en) | 2010-08-27 | 2013-04-11 | New York University | MiR-33 inhibitors and uses thereof |
| US20140031250A1 (en) | 2010-10-07 | 2014-01-30 | David Tsai Ting | Biomarkers of Cancer |
| CN102031261B (zh) * | 2010-10-27 | 2015-04-22 | 南京医科大学 | 一种与妊娠期糖尿病相关的血清/血浆miRNA标志物及其应用 |
| EP2638159B1 (en) * | 2010-11-11 | 2019-04-24 | University of Miami | Compositions, kits and methods for treatment of cardiovascular, immunological, and inflammatory diseases |
| US9920317B2 (en) | 2010-11-12 | 2018-03-20 | The General Hospital Corporation | Polycomb-associated non-coding RNAs |
| EP3260540A1 (en) | 2010-11-12 | 2017-12-27 | The General Hospital Corporation | Polycomb-associated non-coding rnas |
| EP2638912A4 (en) | 2010-11-12 | 2015-01-21 | Nat Univ Corp Ehime Univ | COMPOSITIONS WITH AN ANTISENSE OLIGONUCLEOTIDE AGAINST MICRO RNA |
| ES2606146T3 (es) | 2010-11-12 | 2017-03-22 | The Ohio State University Research Foundation | Métodos relacionados con microARN-21 y reparación de desapareamiento en cáncer colorrectal |
| BR112013011942A2 (pt) | 2010-11-15 | 2016-11-01 | Univ Michigan | formulação, forma de dosagem de droga para administração transmucosa oral, sistema transmucoso de fornecimento de droga, método de tratamento e profilaxia de uma doença ou distúrbio, método de tratamento, formulação, método para tratamento ou prevenção de carcinoma de célula escamosa de cabeça e pescoço (hnscc), método para quimioprevenção de um câncer oral ou condição pré-cancerosa, método para aumentar a concentração de uma composição de retinida, método de tratamento e profilaxia de uma doença ou condição, método de ratamento de um sujeito apresentando uma condição médica sintomática, método de tratamento de um câncer oral ou condição pré-cancerosa num paciente, método para fazer um sistema de fornecimento de droga bucal, método para aumentar a liberação e permeação de uma composição de retinida. |
| CN102041316A (zh) * | 2010-11-30 | 2011-05-04 | 华东师范大学 | miRNA-219化合物作为脑胶质瘤标志物的应用 |
| WO2012083005A2 (en) * | 2010-12-15 | 2012-06-21 | Miragen Therapeutics | Microrna inhibitors comprising locked nucleotides |
| US9308217B2 (en) | 2010-12-20 | 2016-04-12 | Agency For Science, Technology And Research | Targeting glioma stem cells by sequence-specific functional inhibition of pro-survival oncomir-138 |
| US9045749B2 (en) | 2011-01-14 | 2015-06-02 | The General Hospital Corporation | Methods targeting miR-128 for regulating cholesterol/lipid metabolism |
| CN102174516A (zh) * | 2011-01-20 | 2011-09-07 | 中南大学 | 一种与ebv感染相关的鼻咽癌诊断和治疗的分子靶标及其应用 |
| EP2683387A4 (en) | 2011-03-07 | 2014-09-03 | Univ Ohio State | MUTATOR ACTIVITY INDUCED BY MICRORNA-155 (miR-155) LINKS INFLAMMATION AND CANCER |
| AU2012242761A1 (en) | 2011-04-12 | 2013-10-31 | Beth Israel Deaconess Medical Center, Inc. | Micro-RNA inhibitors and their uses in disease |
| WO2012145374A1 (en) | 2011-04-19 | 2012-10-26 | Regulus Therapeutics Inc. | TARGETING miR-378 FAMILY MEMBERS FOR THE TREATMENT OF METABOLIC DISORDERS |
| CN103620035B (zh) | 2011-04-25 | 2021-04-23 | 赛诺菲 | 用于调节mir-21活性的微rna化合物以及方法 |
| WO2012149557A1 (en) | 2011-04-28 | 2012-11-01 | New York University | miR-33 INHIBITORS AND USES THEREOF TO DECREASE INFLAMMATION |
| JP2014522814A (ja) | 2011-06-23 | 2014-09-08 | ステラ・アンパルトセルスカブ | Hcv併用療法 |
| WO2012175357A1 (en) * | 2011-06-24 | 2012-12-27 | Syddansk Universitet | Modulation of microrna-138 for the treatment of bone loss |
| KR20140058536A (ko) | 2011-06-30 | 2014-05-14 | 스텔라 에이피에스 | Hcv 조합 치료 |
| JP2014520772A (ja) | 2011-06-30 | 2014-08-25 | ステラ・アンパルトセルスカブ | Hcv併用療法 |
| CN102908621A (zh) * | 2011-08-02 | 2013-02-06 | 中国科学院上海生命科学研究院 | miRNAs作为调节胰岛素敏感性的靶标的新用途 |
| US9434944B2 (en) | 2011-08-31 | 2016-09-06 | University Of Zurich | Modulators of miR-323-3p for the prevention or treatment of rheumatoid arthritis |
| CN102978278B (zh) * | 2011-09-07 | 2016-09-28 | 中国科学院动物研究所 | 内源性的非编码小RNAs及其应用 |
| EP3533873A1 (en) | 2011-09-14 | 2019-09-04 | Translate Bio MA, Inc. | Multimeric oligonucleotide compounds |
| KR20140091688A (ko) | 2011-10-06 | 2014-07-22 | 미라젠 세러퓨틱스 인코포레이티드 | 마이크로rna 조절에 의한 전신 에너지 항상성의 제어 |
| GB201117482D0 (en) * | 2011-10-11 | 2011-11-23 | Univ Dundee | Targetiing of miRNA precursors |
| AU2012322788B2 (en) | 2011-10-11 | 2018-01-04 | The Brigham And Women's Hospital, Inc. | Micrornas in neurodegenerative disorders |
| CN104364390B (zh) | 2011-10-14 | 2016-08-24 | 俄亥俄州立大学 | 与卵巢癌相关的方法和材料 |
| WO2013068348A1 (en) | 2011-11-07 | 2013-05-16 | Santaris Pharma A/S | Lna oligomers for improvement in hepatic function |
| EP2776590B1 (en) | 2011-11-07 | 2016-10-26 | Roche Innovation Center Copenhagen A/S | Prognostic method for checking efficacy of micro rna-122 inhibitors in hcv+ patients |
| CA2859430A1 (en) * | 2011-12-13 | 2013-06-20 | Ohio State Innovation Foundation | Methods and compositions related to mir-21 and mir-29a, exosome inhibition, and cancer metastasis |
| WO2013088338A1 (en) * | 2011-12-15 | 2013-06-20 | Oncostamen S.R.L. | Micrornas and uses therof |
| US9447471B2 (en) * | 2011-12-29 | 2016-09-20 | Quest Diagnostics Investments Incorporated | Microrna profiling for diagnosis of dysplastic nevi and melanoma |
| CA2866052A1 (en) | 2012-01-20 | 2013-07-25 | The Ohio State University | Breast cancer biomarker signatures for invasiveness and prognosis |
| BR112014026639A8 (pt) * | 2012-04-25 | 2018-01-16 | Regulus Therapeutics Inc | compostos , métodos de inibição da atividade de mir-21 , método para diminuir a expressão de colágeno , método para tratar , prevenir ou atrasar o início de uma doença , método de tratamento de um distúrbio fibroproliferativo e usos de um composto. |
| WO2013170146A1 (en) | 2012-05-10 | 2013-11-14 | Uab Research Foundation | Methods and compositions for modulating mir-204 activity |
| KR20160074368A (ko) | 2012-05-16 | 2016-06-28 | 라나 테라퓨틱스, 인크. | Utrn 발현을 조절하기 위한 조성물 및 방법 |
| EP2850182A4 (en) | 2012-05-16 | 2016-01-20 | Rana Therapeutics Inc | COMPOSITIONS AND METHODS FOR MODULATING ATP2A2 GENE EXPRESSION |
| CA2873769A1 (en) | 2012-05-16 | 2013-11-21 | Rana Therapeutics Inc. | Compositions and methods for modulating hemoglobin gene family expression |
| AU2013262709A1 (en) | 2012-05-16 | 2015-01-22 | Rana Therapeutics, Inc. | Compositions and methods for modulating MECP2 expression |
| US10837014B2 (en) | 2012-05-16 | 2020-11-17 | Translate Bio Ma, Inc. | Compositions and methods for modulating SMN gene family expression |
| DK2850189T3 (en) | 2012-05-16 | 2019-02-25 | Translate Bio Ma Inc | COMPOSITIONS AND PROCEDURES FOR MODULATING GENEPRESSION |
| DK2850186T3 (en) | 2012-05-16 | 2019-04-08 | Translate Bio Ma Inc | COMPOSITIONS AND PROCEDURES FOR MODULATING SMN GENFAMILY EXPRESSION |
| US9163235B2 (en) | 2012-06-21 | 2015-10-20 | MiRagen Therapeutics, Inc. | Inhibitors of the miR-15 family of micro-RNAs |
| CA2876180C (en) * | 2012-06-21 | 2019-11-19 | MiRagen Therapeutics, Inc. | Oligonucleotide-based inhibitors comprising locked nucleic acid motif |
| WO2013190091A1 (en) * | 2012-06-21 | 2013-12-27 | Ruprecht-Karls-Universität Heidelberg | CIRCULATING miRNAs AS MARKERS FOR BREAST CANCER |
| US9845465B2 (en) | 2012-08-15 | 2017-12-19 | University Of Virginia Patent Foundation | Compositions and methods for treating peripheral arterial disease |
| US9790492B2 (en) | 2012-08-20 | 2017-10-17 | National Cancer Center | Agent for treating cancer |
| US20150247141A1 (en) | 2012-09-14 | 2015-09-03 | Rana Therapeutics, Inc. | Multimeric oligonucleotide compounds |
| UA116639C2 (uk) | 2012-10-09 | 2018-04-25 | Рег'Юлес Терап'Ютікс Інк. | Способи лікування синдрому альпорта |
| EP2914344B1 (en) * | 2012-10-31 | 2020-01-15 | The Rockefeller University | Treatment of metastatic colon cancer |
| RU2015119411A (ru) | 2012-11-15 | 2017-01-10 | Рош Инновейшен Сентер Копенгаген А/С | Конъюгаты антисмысловых соединений, направленные на аполипопротеин в |
| WO2014082644A1 (en) * | 2012-11-30 | 2014-06-05 | WULFF, Peter, Samuel | Circular rna for inhibition of microrna |
| WO2014118272A1 (en) | 2013-01-30 | 2014-08-07 | Santaris Pharma A/S | Antimir-122 oligonucleotide carbohydrate conjugates |
| WO2014118267A1 (en) | 2013-01-30 | 2014-08-07 | Santaris Pharma A/S | Lna oligonucleotide carbohydrate conjugates |
| EP2970968B1 (en) * | 2013-03-15 | 2018-01-10 | Miragen Therapeutics, Inc. | Bridged bicyclic nucleosides |
| CN105188715B (zh) * | 2013-03-15 | 2018-12-25 | 米拉根医疗股份有限公司 | Mir-145的锁定核酸抑制剂及其用途 |
| US9428537B2 (en) | 2013-03-15 | 2016-08-30 | The Board Of Trustees Of The Leland Stanford Junior University | tRNA derived small RNAs (tsRNAs) involved in cell viability |
| US9506030B2 (en) | 2013-05-01 | 2016-11-29 | Regulus Therapeutics Inc. | Compounds and methods for enhanced cellular uptake |
| NZ630890A (en) | 2013-05-01 | 2017-09-29 | Regulus Therapeutics Inc | Microrna compounds and methods for modulating mir-122 |
| CN103293318B (zh) * | 2013-05-22 | 2014-10-29 | 吉林大学 | 利用地高辛标记EDC交联桥连法检测miRNAs方法 |
| EP3007706A4 (en) * | 2013-06-12 | 2017-05-17 | New York University | Anti-mir-27b and anti-mir-148a oligonucleotides as therapeutic tools for treating dyslipidemias and cardiovascular diseases |
| WO2014201314A1 (en) | 2013-06-14 | 2014-12-18 | Joslin Diabetes Center, Inc. | Microrna and uses in brown fat differentiation |
| SG10201908122XA (en) | 2013-06-27 | 2019-10-30 | Roche Innovation Ct Copenhagen As | Antisense oligomers and conjugates targeting pcsk9 |
| US20160186171A1 (en) * | 2013-07-24 | 2016-06-30 | The General Hospital Corporation | Agents and methods for inhibiting mir-148a for the modulation of cholesterol levels |
| JP6443889B2 (ja) * | 2013-08-08 | 2018-12-26 | 国立大学法人大阪大学 | 尿路上皮癌の診断または治療剤 |
| EP3060664B1 (en) | 2013-10-25 | 2021-07-07 | Sanofi | Microrna compounds and methods for modulating mir-21 activity |
| US9458458B2 (en) | 2013-11-11 | 2016-10-04 | Emory University | Manipulating microRNA for the management of neurological diseases or conditions and compositions related thereto |
| US20160362688A1 (en) * | 2014-02-12 | 2016-12-15 | Thomas Jefferson University | Compositions and methods of using microrna inhibitors |
| WO2015175545A1 (en) | 2014-05-12 | 2015-11-19 | The Johns Hopkins University | Highly stable biodegradable gene vector platforms for overcoming biological barriers |
| CA2948844C (en) | 2014-05-12 | 2020-06-30 | The Johns Hopkins University | Engineering synthetic brain penetrating gene vectors |
| EP3760208B1 (en) | 2014-06-25 | 2024-05-29 | The General Hospital Corporation | Targeting human satellite ii (hsatii) |
| US10472626B2 (en) * | 2014-07-31 | 2019-11-12 | Agency For Science, Technology And Research | Modified antimir-138 oligonucleotides |
| JP2017523790A (ja) | 2014-08-07 | 2017-08-24 | レグルス セラピューティクス インコーポレイテッド | 代謝障害のためのマイクロrnaの標的化 |
| US10174320B2 (en) | 2014-09-21 | 2019-01-08 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Downregulating miR-132 for the treatment of lipid related disorders |
| CN104306988B (zh) * | 2014-09-25 | 2017-02-15 | 中国医学科学院基础医学研究所 | miR‑431在制备治疗肌肉疾病的药物中的用途 |
| CA2966044A1 (en) | 2014-10-30 | 2016-05-06 | The General Hospital Corporation | Methods for modulating atrx-dependent gene repression |
| JP2017534281A (ja) * | 2014-11-10 | 2017-11-24 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 潰瘍性大腸炎に特異的な診断および予後予測のバイオマーカーとしてのmir−214ならびに潰瘍性大腸炎治療のためのmir−214阻害剤 |
| US10597660B2 (en) | 2014-11-14 | 2020-03-24 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (ALS) |
| MX2017006217A (es) * | 2014-11-14 | 2018-05-02 | Voyager Therapeutics Inc | Polinucleotidos moduladores. |
| EP3020813A1 (en) | 2014-11-16 | 2016-05-18 | Neurovision Pharma GmbH | Antisense-oligonucleotides as inhibitors of TGF-R signaling |
| SG11201705907XA (en) | 2015-01-20 | 2017-08-30 | Miragen Therapeutics Inc | Mir-92 inhibitors and uses thereof |
| US10758558B2 (en) | 2015-02-13 | 2020-09-01 | Translate Bio Ma, Inc. | Hybrid oligonucleotides and uses thereof |
| EP3271460A4 (en) | 2015-03-17 | 2019-03-13 | The General Hospital Corporation | RNA INTERACTOM OF POLYCOMB REPRESSIVE COMPLEX 1 (PRC1) |
| WO2016164463A1 (en) | 2015-04-07 | 2016-10-13 | The General Hospital Corporation | Methods for reactivating genes on the inactive x chromosome |
| CN107922947A (zh) * | 2015-06-05 | 2018-04-17 | 米拉根医疗股份有限公司 | 用于治疗肌萎缩性侧索硬化症(als)的mir‑155抑制剂 |
| JP6721252B2 (ja) | 2015-06-05 | 2020-07-08 | ミラゲン セラピューティクス, インコーポレイテッド | 皮膚T細胞リンパ腫(CTCL)を処置するためのmiR−155阻害剤 |
| CN108139375A (zh) | 2015-06-26 | 2018-06-08 | 贝斯以色列女执事医疗中心股份有限公司 | 靶向髓样衍生的抑制细胞中的四跨膜蛋白33(tspan33)的癌症疗法 |
| US20180221393A1 (en) | 2015-08-03 | 2018-08-09 | Biokine Therapeutics Ltd. | Cxcr4 binding agents for treatment of diseases |
| KR20180043819A (ko) | 2015-08-24 | 2018-04-30 | 로슈 이노베이션 센터 코펜하겐 에이/에스 | Lna-g 방법 |
| CA2997786A1 (en) * | 2015-09-22 | 2017-03-30 | MiRagen Therapeutics, Inc. | Mir-19 modulators and uses thereof |
| WO2017055423A1 (en) | 2015-10-02 | 2017-04-06 | Roche Innovation Center Copenhagen A/S | Oligonucleotide conjugation process |
| EP3359553B1 (en) * | 2015-10-06 | 2025-03-26 | University Of Virginia Patent Foundation | Compositions for treating diabetic retinopathy |
| JP6666002B2 (ja) | 2015-10-07 | 2020-03-13 | 国立大学法人京都大学 | Tdp−43プロテノパシーの予防又は治療用組成物 |
| WO2017066712A2 (en) | 2015-10-16 | 2017-04-20 | The Children's Medical Center Corporation | Modulators of telomere disease |
| WO2017067970A1 (en) | 2015-10-22 | 2017-04-27 | Roche Innovation Center Copenhagen A/S | In vitro toxicity screening assay |
| AU2016355178B9 (en) | 2015-11-19 | 2019-05-30 | Massachusetts Institute Of Technology | Lymphocyte antigen CD5-like (CD5L)-interleukin 12B (p40) heterodimers in immunity |
| JOP20200228A1 (ar) | 2015-12-21 | 2017-06-16 | Novartis Ag | تركيبات وطرق لخفض تعبير البروتين tau |
| CN107012199A (zh) * | 2016-01-28 | 2017-08-04 | 上海市东方医院 | 一种在血浆和血清中检测miRNA的方法 |
| JP7033072B2 (ja) | 2016-02-25 | 2022-03-09 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | Smoc2を標的化する線維症のための治療方法 |
| KR102372122B1 (ko) | 2016-03-18 | 2022-03-07 | 로슈 이노베이션 센터 코펜하겐 에이/에스 | 아실-보호된 l-lna-구아노신 단량체 |
| US11261209B2 (en) | 2016-05-12 | 2022-03-01 | Roche Innovation Center Copenhagen A/S | Enhanced coupling of stereodefined oxazaphospholidine phosphoramidite monomers to nucleoside or oligonucleotide |
| MX2018014152A (es) | 2016-05-18 | 2019-03-28 | Voyager Therapeutics Inc | Composiciones y métodos para tratar la enfermedad de huntington. |
| KR20240056729A (ko) | 2016-05-18 | 2024-04-30 | 보이저 테라퓨틱스, 인크. | 조절성 폴리뉴클레오티드 |
| US11015196B2 (en) | 2016-05-20 | 2021-05-25 | The General Hospital Corporation | Using microRNAs to control activation status of hepatic stellate cells and to prevent fibrosis in progressive liver diseases |
| JP7049271B2 (ja) | 2016-06-17 | 2022-04-06 | エフ.ホフマン-ラ ロシュ アーゲー | インビトロ腎毒性スクリーニングアッセイ |
| JP7012033B2 (ja) | 2016-06-17 | 2022-02-10 | エフ.ホフマン-ラ ロシュ アーゲー | インビトロ腎毒性スクリーニングアッセイ |
| AU2017296195A1 (en) | 2016-07-11 | 2019-01-24 | Translate Bio Ma, Inc. | Nucleic acid conjugates and uses thereof |
| CN109715218A (zh) * | 2016-07-18 | 2019-05-03 | 嘉安生物治疗有限责任公司 | 用于治疗心脏疾病的组合物和方法 |
| EP3494219A1 (en) | 2016-08-03 | 2019-06-12 | Aalborg Universitet | ANTISENSE OLIGONUCLEOTIDES (ASOs) DESIGNED TO INHIBIT IMMUNE CHECKPOINT PROTEINS |
| ES2659845B1 (es) * | 2016-09-19 | 2019-01-04 | Univ Valencia | Modulación de microRNAs contra la distrofia miotónica tipo 1 y antagonistas de microRNAs para ello |
| US10626395B2 (en) | 2016-10-27 | 2020-04-21 | The General Hospital Corporation | Therapeutic targeting of a microRNA to treat Duchenne muscular dystrophy |
| EP3532638A4 (en) | 2016-10-31 | 2020-07-29 | University of Massachusetts | TARGETING MICROARN-101-3 P IN CARCINOTHERAPY |
| US11584932B2 (en) | 2016-11-01 | 2023-02-21 | The Research Foundation For The State University Of New York | 5-halouracil-modified microRNAs and their use in the treatment of cancer |
| EP3558328A4 (en) | 2016-12-22 | 2020-08-26 | Ohio State Innovation Foundation | COMPOSITIONS AND METHODS FOR REPROGRAMMING SOMATIC CELLS INTO INDUCED VASCULOGENIC CELLS |
| EP3601310B1 (en) | 2017-03-29 | 2021-04-14 | Roche Innovation Center Copenhagen A/S | Unylinker rapid cleavage |
| US11591362B2 (en) | 2017-03-29 | 2023-02-28 | Roche Innovation Center Copenhagen A/S | Orthogonal protecting groups for the preparation of stereodefined phosphorothioate oligonucleotides |
| WO2018195486A1 (en) | 2017-04-21 | 2018-10-25 | The Broad Institute, Inc. | Targeted delivery to beta cells |
| AU2018261003A1 (en) | 2017-05-05 | 2019-11-14 | Voyager Therapeutics, Inc. | Compositions and methods of treating Huntington's Disease |
| AU2018261790B2 (en) | 2017-05-05 | 2024-10-03 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (ALS) |
| EP3645544B1 (en) | 2017-06-28 | 2023-05-10 | Roche Innovation Center Copenhagen A/S | Multiple coupling&oxidation method |
| WO2019073018A1 (en) | 2017-10-13 | 2019-04-18 | Roche Innovation Center Copenhagen A/S | METHODS OF IDENTIFYING ANTISENSE OLIGONUCLEOTIDE IMPROVED OLIGONUCLEOTIDE PHOSPHOROTHIOATE STEREODEFINIS VARIANTS USING PARTIALLY STEREODEFINIS OLIGONUCLEOTIDE SUB LIBRARIES |
| WO2019079242A1 (en) | 2017-10-16 | 2019-04-25 | Voyager Therapeutics, Inc. | TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) |
| WO2019079240A1 (en) | 2017-10-16 | 2019-04-25 | Voyager Therapeutics, Inc. | TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) |
| US11413288B2 (en) | 2017-11-01 | 2022-08-16 | Dana-Farber Cancer Institute, Inc. | Methods of treating cancers |
| CN108272815B (zh) * | 2017-12-06 | 2020-09-11 | 南方医科大学深圳医院 | EB病毒miR-BART10-5p抑制剂的应用 |
| CN108220381A (zh) * | 2017-12-07 | 2018-06-29 | 国家卫生计生委科学技术研究所 | 试剂在制备药物中的用途以及筛选药物的方法 |
| EP4092118A1 (en) | 2017-12-22 | 2022-11-23 | Roche Innovation Center Copenhagen A/S | Novel thiophosphoramidites |
| MX2020005754A (es) | 2017-12-22 | 2020-08-20 | Roche Innovation Ct Copenhagen As | Oligonucleotidos gapmeros que comprenden un enlace internucleosido fosforoditioato. |
| CA3085406A1 (en) | 2017-12-22 | 2019-06-27 | Roche Innovation Center Copenhagen A/S | Oligonucleotides comprising a phosphorodithioate internucleoside linkage |
| EP3737424A4 (en) | 2018-01-10 | 2021-10-27 | Translate Bio MA, Inc. | COMPOSITIONS AND METHODS TO FACILITATE THE DELIVERY OF SYNTHETIC NUCLEIC ACIDS INTO CELLS |
| JP7318166B2 (ja) * | 2018-03-14 | 2023-08-01 | ベス イスラエル デアコネス メディカル センター | マイクロrna22の阻害剤 |
| CN108220427B (zh) * | 2018-03-20 | 2021-09-28 | 南京大学 | 一种用于鉴别诊断BHD综合征与原发性自发性气胸的血浆microRNA标记物及应用 |
| WO2019217369A1 (en) | 2018-05-08 | 2019-11-14 | Regulus Therapeutics Inc. | Galnac conjugated modified oligonucleotide as mir-122 inhibitor having hcv antiviral activity with reduced hyperbilirubinemia side-effect |
| US20210220387A1 (en) * | 2018-05-18 | 2021-07-22 | Hoffmann-La Roche, Inc. | Pharmaceutical compositions for treatment of microrna related diseases |
| US11679100B2 (en) | 2018-05-30 | 2023-06-20 | The Regents Of The University Of California | Methods of enhancing immunity |
| CN110777199B (zh) * | 2018-07-24 | 2023-11-14 | 长庚医疗财团法人高雄长庚纪念医院 | 干癣性关节炎的诊断及治疗及其相应的试剂盒 |
| EP4122943B1 (en) | 2018-07-31 | 2024-05-29 | Roche Innovation Center Copenhagen A/S | Oligonucleotides comprising a phosphorotrithioate internucleoside linkage |
| WO2020025527A1 (en) | 2018-07-31 | 2020-02-06 | Roche Innovation Center Copenhagen A/S | Oligonucleotides comprising a phosphorotrithioate internucleoside linkage |
| CN120519574A (zh) | 2018-08-23 | 2025-08-22 | 罗氏创新中心哥本哈根有限公司 | 微小rna-134生物标志物 |
| CA3110661A1 (en) | 2018-08-29 | 2020-03-05 | University Of Massachusetts | Inhibition of protein kinases to treat friedreich ataxia |
| EP3620519A1 (en) | 2018-09-04 | 2020-03-11 | F. Hoffmann-La Roche AG | Use of isolated milk extracellular vesicles for delivering oligonucleotides orally |
| CN110468202A (zh) * | 2019-01-18 | 2019-11-19 | 宁夏医科大学 | 一种靶向TIGIT的miR-206作为肝癌诊断和治疗新型分子的用途 |
| WO2020152303A1 (en) | 2019-01-25 | 2020-07-30 | F. Hoffmann-La Roche Ag | Lipid vesicle for oral drug delivery |
| BR112021016460A2 (pt) | 2019-02-20 | 2021-10-13 | Roche Innovation Center Copenhagen A/S | Oligonucleotídeo gapmer antissenso de fita simples, sal farmaceuticamente aceitável de um oligonucleotídeo, conjugado, composição farmacêutica e invenção |
| MX2021009949A (es) | 2019-02-20 | 2021-09-21 | Roche Innovation Ct Copenhagen As | Fosforamiditas novedosas. |
| EP3904518A4 (en) * | 2019-02-26 | 2023-10-11 | Seoul National University R & DB Foundation | PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF CANCER, COMPRISING A TUT4/7 EXPRESSION MODULATOR |
| CN113474633A (zh) | 2019-02-26 | 2021-10-01 | 罗氏创新中心哥本哈根有限公司 | 寡核苷酸配制方法 |
| CN113905744A (zh) | 2019-05-31 | 2022-01-07 | 阿利戈斯治疗公司 | 经修饰的间隙子寡核苷酸及其使用方法 |
| AU2020303447A1 (en) | 2019-06-26 | 2022-01-27 | Biorchestra Co., Ltd. | Micellar nanoparticles and uses thereof |
| CN110548041A (zh) * | 2019-08-30 | 2019-12-10 | 中国医科大学附属盛京医院 | LNA-anti-miR-150在制备预防或治疗肾脏纤维化药物中的用途 |
| CN111057790B (zh) * | 2019-12-11 | 2022-08-30 | 石河子大学 | miRNA在制备用于检测KSHV潜伏感染的试剂盒中的用途 |
| CA3167206A1 (en) * | 2020-02-14 | 2021-10-07 | The Board Of Trustees Of The Leland Stanford Junior University | Pan-genotypic agents against respiratory viruses and methods of using the same |
| JP2023516142A (ja) | 2020-02-28 | 2023-04-18 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Cd73エクソン7スプライシングを調節するためのオリゴヌクレオチド |
| AR121490A1 (es) * | 2020-03-02 | 2022-06-08 | Mitsubishi Tanabe Pharma Corp | Prevención o tratamiento de aneurismas con substancia inhibidora de mir-33b |
| KR102555878B1 (ko) * | 2020-04-23 | 2023-07-17 | 주식회사 바이오오케스트라 | 하향조절된 mirna의 진단 및 치료를 위한 용도 |
| KR102691806B1 (ko) * | 2020-04-23 | 2024-08-06 | 주식회사 바이오오케스트라 | 상향조절된 mirna의 진단 및 치료를 위한 용도 |
| US20230407401A1 (en) * | 2020-05-29 | 2023-12-21 | National Institute Of Immunology | Dna damage dependent microrna signature for cancers, methods and uses related thereto |
| WO2021251526A1 (ko) * | 2020-06-11 | 2021-12-16 | 주식회사 프로스테믹스 | 신규한 mirna 유사체 및 이의 용도 |
| WO2021262919A2 (en) | 2020-06-26 | 2021-12-30 | The Research Foundation For The State University Of New York | 5-halouracil-modified micrornas and their use in the treatment of cancer |
| CN112301130B (zh) * | 2020-11-12 | 2021-11-30 | 苏州京脉生物科技有限公司 | 一种肺癌早期检测的标志物、试剂盒及方法 |
| JP2024506371A (ja) | 2021-02-12 | 2024-02-13 | メランド ファーマシューティカルズ,インコーポレイテッド | 低酸素症及び虚血関連障害を処置する薬剤、組成物及び方法 |
| AU2022287241A1 (en) | 2021-06-04 | 2023-12-14 | Neumirna Therapeutics Aps | Antisense oligonucleotides targeting adenosine kinase |
| WO2022260162A1 (ja) * | 2021-06-11 | 2022-12-15 | 国立大学法人京都大学 | Nashの予防及び/又は治療剤 |
| EP4105328A1 (en) | 2021-06-15 | 2022-12-21 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Antisense-oligonucleotides for prevention of kidney dysfunction promoted by endothelial dysfunction by ephrin-b2 suppression |
| WO2023013818A1 (ko) * | 2021-08-06 | 2023-02-09 | 주식회사 네오나 | 변형된 rt-let7을 유효성분으로 포함하는 간암의 예방 또는 치료용 조성물 |
| KR102329524B1 (ko) * | 2021-08-06 | 2021-11-23 | 주식회사 네오나 | 변형된 rt-let7을 유효성분으로 포함하는 간암의 예방 또는 치료용 조성물 |
| JP2024531342A (ja) | 2021-08-19 | 2024-08-29 | ニューミルナ セラピューティクス エーピーエス | アデノシンキナーゼを標的とするアンチセンスオリゴヌクレオチド |
| EP4413133A2 (en) * | 2021-10-08 | 2024-08-14 | Regulus Therapeutics Inc. | Methods and compositions for avoiding off-target effects |
| KR102711428B1 (ko) * | 2022-04-28 | 2024-09-26 | 차의과학대학교 산학협력단 | 삼중음성유방암의 예방, 개선 또는 치료용 약학 조성물 |
| WO2024026474A1 (en) | 2022-07-29 | 2024-02-01 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for transferrin receptor (tfr)-mediated delivery to the brain and muscle |
| US20240182561A1 (en) | 2022-11-04 | 2024-06-06 | Regeneron Pharmaceuticals, Inc. | Calcium voltage-gated channel auxiliary subunit gamma 1 (cacng1) binding proteins and cacng1-mediated delivery to skeletal muscle |
| AU2023379457A1 (en) | 2022-11-14 | 2025-05-15 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes |
| WO2024112653A1 (en) * | 2022-11-22 | 2024-05-30 | The Regents Of The University Of California | Inhibitory nucleic acids and methods of use thereof |
| CN120936364A (zh) | 2023-01-27 | 2025-11-11 | 瑞泽恩制药公司 | 修饰的弹状病毒糖蛋白及其用途 |
| CN118006611B (zh) * | 2024-02-23 | 2025-03-18 | 广东省科学院动物研究所 | 一种杀白蚁的miRNA及其联合绿僵菌防治白蚁的方法 |
| WO2025181198A1 (en) * | 2024-02-27 | 2025-09-04 | Novo Nordisk A/S | Treatment and prevention of cardiac and fibrotic disorders |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003029459A2 (en) | 2001-09-28 | 2003-04-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Micro-rna molecules |
| WO2004046160A2 (en) * | 2002-11-18 | 2004-06-03 | Santaris Pharma A/S | Amino-lna, thio-lna and alpha-l-oxy-ln |
| US20050227934A1 (en) | 2004-04-13 | 2005-10-13 | Markus Stoffel | Pancreatic islet microRNA and methods for inhibiting same |
| US20050261218A1 (en) | 2003-07-31 | 2005-11-24 | Christine Esau | Oligomeric compounds and compositions for use in modulation small non-coding RNAs |
Family Cites Families (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4914210A (en) | 1987-10-02 | 1990-04-03 | Cetus Corporation | Oligonucleotide functionalizing reagents |
| US4962029A (en) | 1987-10-02 | 1990-10-09 | Cetus Corporation | Covalent oligonucleotide-horseradish peroxidase conjugate |
| US4920115A (en) | 1988-12-28 | 1990-04-24 | Virginia Commonwealth University | Method of lowering LDL cholesterol in blood |
| JPH06311885A (ja) | 1992-08-25 | 1994-11-08 | Mitsubishi Kasei Corp | C型肝炎ウイルス遺伝子に相補的なアンチセンス化合物 |
| US6433159B1 (en) * | 1992-09-10 | 2002-08-13 | Isis Pharmaceuticals, Inc. | Compositions and methods for treatment of Hepatitis C virus associated diseases |
| US6423489B1 (en) * | 1992-09-10 | 2002-07-23 | Isis Pharmaceuticals, Inc. | Compositions and methods for treatment of Hepatitis C virus-associated diseases |
| JPH08506479A (ja) * | 1992-09-10 | 1996-07-16 | 財団法人化学及血清療法研究所 | C型肝炎ウイルス関連疾患の治療のための組成物および方法 |
| EP0759979A4 (en) | 1994-05-10 | 1999-10-20 | Gen Hospital Corp | THE ANTISENSE INHIBITION OF HEPATITIS C VIRUS |
| US5919795A (en) | 1995-06-07 | 1999-07-06 | Pfizer Inc. | Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and their use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (Apo B) secretion |
| WO1998023593A1 (en) | 1996-11-27 | 1998-06-04 | Pfizer Inc. | Apo b-secretion/mtp inhibitory amides |
| NZ337703A (en) * | 1997-03-05 | 2001-05-25 | Univ Washington | A screening method to identify agents that selectively inhibit Hepatitis C virus replication in viruses that contain an ISDR region |
| WO1999014226A2 (en) | 1997-09-12 | 1999-03-25 | Exiqon A/S | Bi- and tri-cyclic nucleoside, nucleotide and oligonucleotide analogues |
| KR20020013513A (ko) | 1999-03-18 | 2002-02-20 | 추후제출 | Xylo-lna 유사체 |
| ATE332909T1 (de) | 1999-03-24 | 2006-08-15 | Exiqon As | Verbesserte synthese für 2.2.1.öbicyclo- nukleoside |
| US7098192B2 (en) * | 1999-04-08 | 2006-08-29 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of STAT3 expression |
| CN102180924A (zh) | 1999-05-04 | 2011-09-14 | 桑塔里斯制药公司 | L-核糖-lna类似物 |
| US6617442B1 (en) | 1999-09-30 | 2003-09-09 | Isis Pharmaceuticals, Inc. | Human Rnase H1 and oligonucleotide compositions thereof |
| WO2001025248A2 (en) | 1999-10-04 | 2001-04-12 | Exiqon A/S | Design of high affinity rnase h recruiting oligonucleotide |
| IL139450A0 (en) | 1999-11-10 | 2001-11-25 | Pfizer Prod Inc | Methods of administering apo b-secretion/mtp inhibitors |
| JP4413493B2 (ja) | 2000-10-04 | 2010-02-10 | サンタリス ファーマ アー/エス | プリンlna類似体の改善された合成方法 |
| WO2002069904A2 (en) | 2001-03-02 | 2002-09-12 | Medimmune, Inc. | Cd2 antagonists for treatment of autoimmune or inflammatory disease |
| JP2004532022A (ja) | 2001-03-26 | 2004-10-21 | サーナ・セラピューティクス・インコーポレイテッド | B型肝炎ウイルスおよびc型肝炎ウイルスの複製のオリゴヌクレオチド媒介性阻害 |
| AU2002317437A1 (en) | 2001-05-18 | 2002-12-03 | Cureon A/S | Therapeutic uses of lna-modified oligonucleotides in infectious diseases |
| AU2002328792A1 (en) | 2001-07-12 | 2003-01-29 | Santaris Pharma A/S | Method for preparation of lna phosphoramidites |
| US7407943B2 (en) | 2001-08-01 | 2008-08-05 | Isis Pharmaceuticals, Inc. | Antisense modulation of apolipoprotein B expression |
| JP2005514005A (ja) * | 2001-09-04 | 2005-05-19 | エクシコン エ/エス | 新規のlna組成物およびその使用 |
| JP2005517427A (ja) | 2002-02-20 | 2005-06-16 | サーナ・セラピューティクス・インコーポレイテッド | 短干渉核酸(siNA)を用いるC型肝炎ウイルス(HCV)遺伝子発現のRNA干渉媒介性阻害 |
| EP1432724A4 (en) * | 2002-02-20 | 2006-02-01 | Sirna Therapeutics Inc | INTERFERENCE MEDIATION INHIBITION OF GENE RNA FROM MAP KINASE |
| DK1501848T3 (da) | 2002-05-08 | 2007-10-22 | Santaris Pharma As | Syntese af låst nukleinsyrederivater |
| US20050069522A1 (en) * | 2002-08-12 | 2005-03-31 | Richard Colonno | Combination pharmaceutical agents as inhibitors of HCV replication |
| UA79300C2 (en) | 2002-08-12 | 2007-06-11 | Janssen Pharmaceutica Nv | N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b secretion |
| US7087229B2 (en) | 2003-05-30 | 2006-08-08 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| EP2336318B1 (en) | 2002-11-13 | 2013-04-24 | Genzyme Corporation | Antisense modulation of apolipoprotein b expression |
| US8124582B2 (en) | 2002-12-06 | 2012-02-28 | Fibrogen, Inc. | Treatment of diabetes |
| FR2848572B1 (fr) * | 2002-12-12 | 2005-12-09 | Univ Joseph Fourier | Molecules inhibitrices de la synthese proteique du virus de l'hepatite c et procede de criblage desdites molecules inhibitrices |
| CA2515644A1 (en) * | 2003-02-10 | 2004-08-19 | Santaris Pharma A/S | Oligomeric compounds for the modulation of ras expression |
| PT1592793E (pt) | 2003-02-10 | 2009-09-30 | Santaris Pharma As | Compostos oligoméricos para a modulação da expressão de survivina |
| CN1768139A (zh) | 2003-02-10 | 2006-05-03 | 独立行政法人产业技术总合研究所 | 通过dna干扰调控基因的表达 |
| EP1606406B2 (en) * | 2003-03-21 | 2013-11-27 | Santaris Pharma A/S | SHORT INTERFERING RNA (siRNA) ANALOGUES |
| AU2004233092C9 (en) * | 2003-04-17 | 2010-10-28 | Alnylam Pharmaceuticals, Inc. | Modified iRNA agents |
| AU2004263124B2 (en) | 2003-08-07 | 2009-01-15 | Avi Biopharma, Inc. | Sense antiviral compound and method for treating ssRNA viral infection |
| US20050142581A1 (en) | 2003-09-04 | 2005-06-30 | Griffey Richard H. | Microrna as ligands and target molecules |
| US8685946B2 (en) | 2003-11-26 | 2014-04-01 | Universiy of Massachusetts | Sequence-specific inhibition of small RNA function |
| UA83510C2 (en) | 2003-12-09 | 2008-07-25 | Янссен Фармацевтика Н.В. | N-aryl piperidine substituted biphenylcarboxamides as inhibitors of apolipoprotein b |
| EP1706489B9 (en) * | 2003-12-23 | 2011-01-05 | Santaris Pharma A/S | Oligomeric compounds for the modulation of bcl-2 |
| CA2554818A1 (en) | 2004-02-09 | 2005-08-25 | Thomas Jefferson University | Diagnosis and treatment of cancers with microrna located in or near cancer-associated chromosomal features |
| CA2556435C (en) * | 2004-02-13 | 2014-08-12 | The Rockefeller University | Anti-microrna oligonucleotide molecules |
| US20050182005A1 (en) | 2004-02-13 | 2005-08-18 | Tuschl Thomas H. | Anti-microRNA oligonucleotide molecules |
| DK1735459T3 (da) | 2004-04-07 | 2012-05-29 | Exiqon As | Fremgangsmåder til kvantificering af microRNA'er og små interfererende RNA'er |
| US7811759B2 (en) * | 2004-04-20 | 2010-10-12 | Jian Han | Method for detecting ncRNA |
| CA2564503C (en) | 2004-05-04 | 2015-12-29 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of mir-122 in hepatitis c virus infected subjects and cells |
| CA2574088C (en) | 2004-07-21 | 2013-09-17 | Alnylam Pharmaceuticals, Inc. | Oligonucleotides comprising a modified or non-natural nucleobase |
| US20080213891A1 (en) | 2004-07-21 | 2008-09-04 | Alnylam Pharmaceuticals, Inc. | RNAi Agents Comprising Universal Nucleobases |
| FR2873694B1 (fr) | 2004-07-27 | 2006-12-08 | Merck Sante Soc Par Actions Si | Nouveaux aza-indoles inhibiteurs de la mtp et apob |
| WO2006112872A2 (en) | 2004-08-04 | 2006-10-26 | Alnylam Pharmaceuticals, Inc. | Oligonucleotides comprising a ligand tethered to a modified or non-natural nucleobase |
| ES2663810T3 (es) | 2004-08-10 | 2018-04-17 | Kastle Therapeutics, Llc | Métodos para modular los niveles de lipoproteínas y colesterol en humanos |
| JP5192234B2 (ja) | 2004-08-10 | 2013-05-08 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | 化学修飾オリゴヌクレオチド |
| WO2006027776A1 (en) | 2004-09-07 | 2006-03-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Agents, compositions and methods for treating pathologies in which regulating an ache-associated biological pathway is beneficial |
| NZ554214A (en) | 2004-09-24 | 2009-10-30 | Alnylam Pharmaceuticals Inc | Rnai modulation of apob and uses thereof |
| ES2534302T3 (es) | 2004-11-12 | 2015-04-21 | Asuragen, Inc. | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
| AU2005306533B2 (en) | 2004-11-17 | 2012-05-31 | Arbutus Biopharma Corporation | siRNA silencing of apolipoprotein B |
| US20060185027A1 (en) * | 2004-12-23 | 2006-08-17 | David Bartel | Systems and methods for identifying miRNA targets and for altering miRNA and target expression |
| EP1838870A2 (en) | 2004-12-29 | 2007-10-03 | Exiqon A/S | NOVEL OLIGONUCLEOTIDE COMPOSITIONS AND PROBE SEQUENCES USEFUL FOR DETECTION AND ANALYSIS OF MICRORNAS AND THEIR TARGET MRNAs |
| SG164371A1 (en) | 2005-04-19 | 2010-09-29 | Surface Logix Inc | Inhibitors of microsomal triglyceride transfer protein and apo-b secretion |
| US20060265771A1 (en) * | 2005-05-17 | 2006-11-23 | Lewis David L | Monitoring microrna expression and function |
| US20090209621A1 (en) | 2005-06-03 | 2009-08-20 | The Johns Hopkins University | Compositions and methods for decreasing microrna expression for the treatment of neoplasia |
| US20070213292A1 (en) | 2005-08-10 | 2007-09-13 | The Rockefeller University | Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof |
| WO2007021896A2 (en) | 2005-08-10 | 2007-02-22 | Alnylam Pharmaceuticals, Inc. | Chemically modified oligonucleotides for use in modulating micro rna and uses thereof |
| EP2338991B1 (en) * | 2005-08-29 | 2017-01-18 | Regulus Therapeutics Inc. | Methods for use in modulating MIR-122a |
| EP1931780B1 (en) | 2005-08-29 | 2016-01-06 | Regulus Therapeutics Inc. | Antisense compounds having enhanced anti-microrna activity |
| WO2007031081A2 (en) | 2005-09-15 | 2007-03-22 | Santaris Pharma A/S | RNA ANTAGONIST COMPOUNDS FOR THE INHIBITION OF APO-Bl00 EXPRESSION |
| WO2007031091A2 (en) | 2005-09-15 | 2007-03-22 | Santaris Pharma A/S | Rna antagonist compounds for the modulation of p21 ras expression |
| AU2007211082B2 (en) | 2006-01-27 | 2012-09-27 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and compositions for the use in modulation of microRNAs |
| CA3024953A1 (en) | 2006-04-03 | 2007-10-11 | Roche Innovation Center Copenhagen A/S | Pharmaceutical composition comprising anti-mirna antisense oligonucleotides |
| EP2505646A1 (en) | 2006-05-05 | 2012-10-03 | Isis Pharmaceuticals, Inc. | Compounds and methods for modulating expression of CRP |
| US7547684B2 (en) | 2006-05-11 | 2009-06-16 | Isis Pharmaceuticals, Inc. | 5′-modified bicyclic nucleic acid analogs |
| US20080199961A1 (en) | 2006-08-25 | 2008-08-21 | Avi Biopharma, Inc. | ANTISENSE COMPOSITION AND METHOD FOR INHIBITION OF miRNA BIOGENESIS |
| AU2007296055A1 (en) | 2006-09-15 | 2008-03-20 | Enzon Pharmaceuticals, Inc. | Polymeric conjugates containing positively-charged moieties |
| CA2662978A1 (en) | 2006-09-15 | 2008-03-20 | Enzon Pharmaceuticals, Inc. | Hindered ester-based biodegradable linkers for oligonucleotide delivery |
| WO2008046911A2 (en) | 2006-10-20 | 2008-04-24 | Exiqon A/S | Novel human micrornas associated with cancer |
| EP2086590A4 (en) | 2006-10-24 | 2011-04-06 | Univ Leland Stanford Junior | Modulation of t cell signaling threshold and t cell sensitivity to antigens |
| US20100021914A1 (en) | 2006-11-23 | 2010-01-28 | Querdenker Aps | Oligonucleotides for modulating target rna activity |
| WO2008074328A2 (en) | 2006-12-21 | 2008-06-26 | Exiqon A/S | Microrna target site blocking oligos and uses thereof |
| DK2149605T3 (da) | 2007-03-22 | 2013-09-30 | Santaris Pharma As | Korte RNA antagonist forbindelser til modulering af det ønskede mRNA |
| WO2008124384A2 (en) | 2007-04-03 | 2008-10-16 | Aegerion Pharmaceuticals, Inc. | Combinations of mtp inhibitors with cholesterol absorption inhibitors or interferon for treating hepatitis c |
| EP2170917B1 (en) | 2007-05-30 | 2012-06-27 | Isis Pharmaceuticals, Inc. | N-substituted-aminomethylene bridged bicyclic nucleic acid analogs |
| EP2173760B2 (en) | 2007-06-08 | 2015-11-04 | Isis Pharmaceuticals, Inc. | Carbocyclic bicyclic nucleic acid analogs |
| US20090082297A1 (en) | 2007-06-25 | 2009-03-26 | Lioy Daniel T | Compositions and Methods for Regulating Gene Expression |
| WO2009032083A1 (en) | 2007-08-29 | 2009-03-12 | President And Fellows Of Harvard College | Methods of increasing gene expression through rna protection |
| KR101889518B1 (ko) | 2007-10-04 | 2018-08-17 | 로슈 이노베이션 센터 코펜하겐 에이/에스 | 마이크로MIRs |
| WO2009109665A1 (en) | 2008-03-07 | 2009-09-11 | Santaris Pharma A/S | Pharmaceutical compositions for treatment of microrna related diseases |
| WO2010000665A1 (en) | 2008-06-30 | 2010-01-07 | Santaris Pharma A/S | Antidote oligomers |
| US8398734B2 (en) | 2008-08-01 | 2013-03-19 | Twister B.V. | Cyclonic separator with a volute outlet duct |
| JP5773535B2 (ja) | 2009-04-24 | 2015-09-02 | ロシュ・イノベーション・センター・コペンハーゲン・アクティーゼルスカブRoche Innovation Center Copenhagen A/S | インターフェロンに非応答性のhcv患者の治療のための医薬組成物 |
| WO2011048125A1 (en) | 2009-10-20 | 2011-04-28 | Santaris Pharma A/S | Oral delivery of therapeutically effective lna oligonucleotides |
-
2007
- 2007-03-30 CA CA3024953A patent/CA3024953A1/en not_active Abandoned
- 2007-03-30 JP JP2009503410A patent/JP5198430B2/ja not_active Expired - Fee Related
- 2007-03-30 EA EA200870402A patent/EA015570B1/ru not_active IP Right Cessation
- 2007-03-30 EP EP20100158023 patent/EP2194129A3/en not_active Withdrawn
- 2007-03-30 EP EP07722548A patent/EP2007888A2/en not_active Withdrawn
- 2007-03-30 ES ES13172958T patent/ES2715625T3/es active Active
- 2007-03-30 AU AU2007234191A patent/AU2007234191B2/en not_active Ceased
- 2007-03-30 CA CA2648132A patent/CA2648132C/en active Active
- 2007-03-30 CA CA2649045A patent/CA2649045C/en active Active
- 2007-03-30 DK DK13172958.4T patent/DK2666859T3/en active
- 2007-03-30 JP JP2009503411A patent/JP5814505B2/ja not_active Expired - Fee Related
- 2007-03-30 EP EP07722549A patent/EP2007889A2/en not_active Withdrawn
- 2007-03-30 WO PCT/DK2007/000168 patent/WO2007112753A2/en not_active Ceased
- 2007-03-30 MX MX2008012219A patent/MX2008012219A/es active IP Right Grant
- 2007-03-30 WO PCT/DK2007/000169 patent/WO2007112754A2/en not_active Ceased
- 2007-03-30 US US12/296,084 patent/US20100004320A1/en not_active Abandoned
- 2007-03-30 KR KR20087026963A patent/KR101407707B1/ko not_active Expired - Fee Related
- 2007-03-30 CA CA3042781A patent/CA3042781C/en active Active
-
2008
- 2008-09-10 IL IL194007A patent/IL194007A0/en unknown
-
2011
- 2011-01-13 US US13/006,099 patent/US20120083596A1/en not_active Abandoned
-
2012
- 2012-03-08 US US13/415,685 patent/US8729250B2/en active Active
- 2012-11-02 JP JP2012242996A patent/JP2013078317A/ja active Pending
-
2014
- 2014-02-07 JP JP2014022650A patent/JP5872603B2/ja not_active Expired - Fee Related
- 2014-04-04 US US14/245,557 patent/US9133455B2/en active Active
-
2015
- 2015-09-03 US US14/844,088 patent/US20160060627A1/en not_active Abandoned
- 2015-11-11 JP JP2015221396A patent/JP6326025B2/ja not_active Expired - Fee Related
-
2017
- 2017-09-13 US US15/703,598 patent/US20180195062A1/en not_active Abandoned
-
2018
- 2018-09-10 US US16/126,465 patent/US20190071672A1/en not_active Abandoned
-
2020
- 2020-10-01 US US17/061,534 patent/US20210071181A1/en not_active Abandoned
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003029459A2 (en) | 2001-09-28 | 2003-04-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Micro-rna molecules |
| WO2004046160A2 (en) * | 2002-11-18 | 2004-06-03 | Santaris Pharma A/S | Amino-lna, thio-lna and alpha-l-oxy-ln |
| US20050261218A1 (en) | 2003-07-31 | 2005-11-24 | Christine Esau | Oligomeric compounds and compositions for use in modulation small non-coding RNAs |
| US20050227934A1 (en) | 2004-04-13 | 2005-10-13 | Markus Stoffel | Pancreatic islet microRNA and methods for inhibiting same |
Non-Patent Citations (1)
| Title |
|---|
| Science 309(5740): 1577-1581(2005. 9. 2.) * |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101407707B1 (ko) | Anti-mirna 안티센스 올리고뉴클레오타이드를 함유하는 약학적 조성물 | |
| US8163708B2 (en) | Pharmaceutical composition comprising anti-mirna antisense oligonucleotide | |
| EP2203559B1 (en) | Combination treatment for the treatment of hepatitis c virus infection | |
| CN101437942A (zh) | 包含抗微小rna反义寡核苷酸的药物组合物 | |
| AU2013254923A1 (en) | Pharmaceutical compositions comprising anti-miRNA antisense oligonucleotide | |
| AU2012216487B2 (en) | Pharmaceutical composition comprising anti-miRNA antisense oligonucleotides | |
| HK1152075A (en) | Pharmaceutical composition comprising anti-mirna antisense oligonucleotides | |
| AU2014208214A1 (en) | Pharmaceutical composition comprising anti-miRNA antisense oligonucleotides | |
| NZ571620A (en) | Pharmaceutical composition comprising anti-miRNA antisense oligonucleotides | |
| AU2007234192B2 (en) | Pharmaceutical compositions comprising anti-miRNA antisense oligonucleotides | |
| BRPI0709895A2 (pt) | composição farmacêutica |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
St.27 status event code: A-0-1-A10-A15-nap-PA0105 |
|
| PG1501 | Laying open of application |
St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
|
| R18-X000 | Changes to party contact information recorded |
St.27 status event code: A-3-3-R10-R18-oth-X000 |
|
| A201 | Request for examination | ||
| E13-X000 | Pre-grant limitation requested |
St.27 status event code: A-2-3-E10-E13-lim-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| PA0201 | Request for examination |
St.27 status event code: A-1-2-D10-D11-exm-PA0201 |
|
| R18-X000 | Changes to party contact information recorded |
St.27 status event code: A-3-3-R10-R18-oth-X000 |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
St.27 status event code: A-1-2-D10-D21-exm-PE0902 |
|
| T11-X000 | Administrative time limit extension requested |
St.27 status event code: U-3-3-T10-T11-oth-X000 |
|
| E13-X000 | Pre-grant limitation requested |
St.27 status event code: A-2-3-E10-E13-lim-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
St.27 status event code: A-1-2-D10-D22-exm-PE0701 |
|
| GRNT | Written decision to grant | ||
| PR0701 | Registration of establishment |
St.27 status event code: A-2-4-F10-F11-exm-PR0701 |
|
| PR1002 | Payment of registration fee |
St.27 status event code: A-2-2-U10-U12-oth-PR1002 Fee payment year number: 1 |
|
| PG1601 | Publication of registration |
St.27 status event code: A-4-4-Q10-Q13-nap-PG1601 |
|
| PN2301 | Change of applicant |
St.27 status event code: A-5-5-R10-R13-asn-PN2301 St.27 status event code: A-5-5-R10-R11-asn-PN2301 |
|
| FPAY | Annual fee payment |
Payment date: 20170330 Year of fee payment: 4 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 4 |
|
| FPAY | Annual fee payment |
Payment date: 20180329 Year of fee payment: 5 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 5 |
|
| FPAY | Annual fee payment |
Payment date: 20190327 Year of fee payment: 6 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 6 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 7 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 8 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 9 |
|
| PC1903 | Unpaid annual fee |
St.27 status event code: A-4-4-U10-U13-oth-PC1903 Not in force date: 20230610 Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE |
|
| PC1903 | Unpaid annual fee |
St.27 status event code: N-4-6-H10-H13-oth-PC1903 Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE Not in force date: 20230610 |