JP5090130B2 - 医療装置 - Google Patents
医療装置 Download PDFInfo
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- JP5090130B2 JP5090130B2 JP2007284885A JP2007284885A JP5090130B2 JP 5090130 B2 JP5090130 B2 JP 5090130B2 JP 2007284885 A JP2007284885 A JP 2007284885A JP 2007284885 A JP2007284885 A JP 2007284885A JP 5090130 B2 JP5090130 B2 JP 5090130B2
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
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Description
また、例えばポリウレタン、シリコン、ポリエステルのような長期間の組織反応の低い生物安定性ポリマーを用いることができる。そして他のポリマーもまたそのポリマーがステント上で分解し、固化し、重合化するならば用いることができる。このような生物安定性ポリマーの例としては、ポリオレフィン、ポリイソブチレン、およびエチレン−アルファオレフィンコポリマー;アクリルポリマーおよびコポリマー(acrylic polymers and copolymers)、ビニルハライドポリマーおよびコポリマー、たとえばポリ塩化ビニル;ポリビニルエーテ、たとえばポリビニルメチルエーテル;ポリビニリデンハライド、たとえばポリビニリデンフルオライドおよびポリビニリデンクロライド;ポリアクリロラトリル、ポリビニルケトン;ポリビニル芳香族、たとえばポリスチレン;ポリビニルエステル、たとえばポリビニルアセテート;ビニルモノマー同士およびオレフィンとのコポリマー、たとえばエチレン−メチルメタクリレートコポリマー、アクリロニトリル−スチレンコポリマー、ABS樹脂、およびエチレン−酢酸ビニルコポリマー;ポリアミド、たとえばナイロン66およびポリカプロラクタム;アルキド樹脂、ポリカーボネート、ポリオキシメタレン、ポリイミド、ポリエーテル、エポキシ樹脂、ポリウレタン;レーヨン;レーヨン−トリアセテート;セルロース、酢酸セルロース、セルロースブチレート;セロファン;セルロースニトレート;セルロースプロピオネート;セルロースエーテル;およびカルボキシメチルセルロースである。
12 構造体
14 ベース材料
16 付加コーティング層
18 対生物作用材料層
20 多孔質層
22 第2の対生物作用材料層
24 第2の多孔質材料層
26 コネクタ
28 ホール
Claims (9)
- (A) ベース材料(14)を表面に有する構造体(12)と、
(B) 前記構造体(12)の少なくとも一部の上に配置される対生物作用材料層(18)と、
(C) 前記対生物作用材料層(18)の上に配置される生物適合性のある多孔質材料層(20)と、
を有し、
前記多孔質材料層(20)は、生物吸収性であり、生物作用材料の放出を制御することが可能であり、
前記多孔質材料層(20)は、ポリ(L−乳酸)、ポリカプロラクトン、ポリ(ラクチド−コ−グリコリド)、ポリ(ヒドロキシブチレート)、ポリ(ヒドロキシブチレート−コ−バレレート)、ポリジオキサノン、ポリオルソエステル、ポリアンハイドライド、ポリ(グリコール酸)、ポリ(D,L−乳酸)、ポリ(グリコール酸−コ−トリメチレンカーボネート)、ポリホスホエステル、ポリホスホエステルウレタン、ポリ(アミノ酸)、シアノアクリレート、ポリ(トリメチレンカルボネート)、ポリ(イミノカルボネート)、コポリ(エーテル−エステル)、PEO/PLA、ポリアルキレンオキサレート、ポリホスファゼン、および生体分子からなる群から選択される生物吸収性材料を含む、注入用医療装置(10)。 - 前記多孔質材料層(20)の厚さは、5,000−250,000オングストローム(Å)である、請求項1記載の注入用医療装置(10)。
- 前記対生物作用材料層は、前記構造体(12)表面に1cm2当たり1−4mgで存在する、請求項1記載の注入用医療装置(10)。
- 前記構造体(12)と少なくとも1つの前記対生物作用材料層(18)との間に、非多孔質性の追加のポリマー層(16)をさらに有する、請求項1記載の注入用医療装置(10)。
- 前記ベース材料(14)は、ステンレス(stainless steel)、タンタル(tantalum)、チタン(titanium)、ニチノール(Nitinol)、金、プラチナ、インコネル(inconel)、イリジウム(iridium)、銀、タングステン(tungsten)、あるいはこれらの合金;炭素または炭素繊維;セルロースアセテート(cellulose acetate)、セルロースニチレート(cellulose nitrate)、シリコーン、ポリエチレン・テラフタレート(polyethylene teraphtalate)、ポリウレタン、ポリアミド、ポリエステル、ポリオルソエステル(polyorthoester)、ポリアンヒドライド(polyanhydride)、ポリエーテルスルフォン(polyether sulfone)、ポリカーボネート(polycarbonate)、ポリプロピレン(plypropylene)、高分子量ポリエチレン、ポリテトラフルオロエチレン(polytetrafluoroethylene)、あるいはこれらの混合物あるいはコポリマー(copolymer);ポリ乳酸(polylactic acid)、ポリグリコール酸(polyglycolic acid)あるいはそのコポリマー、ポリアンヒドライド(polyanhydride)、ポリカプロラクトン(polycaprolactone)、ポリハイドロキシブチレート・バレレート(polyhydroxy-butyrate valerate)、あるいはこれらの混合物あるいはコポリマーを含み;および/または
前記対生物作用材料は、ヘパリン(heparin)、共役ヘパリン(covalent heparin)、ヒルディン(hirudin)、ヒルログ(hirulog)、アルガトロバン(argatroban)、D−フェニルアラニル−L−ポリ−L−アルジニルクロロメチルケトン(D-phenylalanyl-L-poly-L-arginylchloromethyl ketone)、あるいはそれらの混合物;ウロキネーゼ(urokinase)、ステレプトキネーゼ(streptokinase)、ティッシュプラズミノゲンアクティビエータ(tissue plasminogen activator)、あるいはそれらの混合物;ヒブリノリティック剤(fibrionolytic agent);バソスパズムインヒビタ(vasospasm inhibitor);カルシウムチャネルブロッカー(calcium channel blocker)、ニトレート(nitrate)、ニトリック酸化物(nitric oxide)、ニトリック酸化物プロモータ(nitric oxide promoter)、または他のバソディレータ(vasodilator);アンティミクロビアル剤(antimicrobial agent)あるいはアンティバイオティック(antibiotic)、アスピリン(aspirin)、ティクロピダイン(ticlopidine)、グリコプロテインIIb/IIIaインヒビタ(glycoprotein IIb/IIIa inhibitor);コルキシン(colchicine)、ジメチルスルホキシド(DMSO)、レティノイド(retinoid);シトカラシン(cytochalasin);あるいはリモデリングインヒビタ(remodeling inhibitor);デオキシリボヌクレリック酸(deoxyribonucleic acid)、アンティセンスヌクレオタイド(antisense nucleotide);メトトレキサ(methotrexate)、アンチメタボライト剤(antimetabolite agent)あるいはアンティプロリファラティブ剤(antiproliferative agent)、タクスノール(Taxol)またはその誘導剤;デキサメサソン(dexamethasone)、デキサメサソンソディウムホスファート(dexamethasone sodium phosphate)、デキサメサソンアセテート(dexamethasone acetate);非ステロイドアンティインフラメトリー剤(non-steroidal antiinflammatory agent);サイクロスピン(cyclosporin);トラピラル(PDCFアンタゴニスト)、アンギオペプチン(angiopeptin)(成長ホルモン・アンタゴニスト)、グロースファクタ(growth factor)あるいはアンティグロースファクタ抗体(anti-growth factor antibody);ドーパミン(dopamine)、ブロムクリプティンメシレート(bromocriptine mesylate)、ペルゴライドメシレート(pergolide mesylate);60Co、192Ir、32P、111In、90Y、99Tc;ヨウ素含有化合物、バリウム含有化合物、金、タンタル、プラチナ、タングステン;ペプチド(peptide)、プロテイン、エンザイム(enzyme)、エクストラセルラマトリックスコンポーネント(extracellulate matrix component)、セルラーコンポーネント(cellular component)、カプトプリ(captopril)、エナラプリ(enalapril);アスコルビン酸(ascorbic acid)、アルファトコフェロール(alpha tocopherol)、スーパーオキサイドジスムターゼ(superoxide dismutase)、ディフェロキサミン(deferoxamine)、21−アミノステロイド(ラサロイド)(21-amino steroid(lasaroid));AZT;アシクリバー(acyclovir)、ファミシリクロバー(famciclovir)、リマンタダインハイドロクロライド(rimantadine hydrochloride)、ガンシクロヴィアナトリウム(ganciclovir sodium);5−アミノレボリック酸(5-aminolevulinic acid)、メタ−テトラヒドロキシフェニルクロリン(meta-tetrahydroxyphenylchlorin)、ヘキサデカフルオロ鉛フタロシナニン(hexadecafluoro zinc phthalocyanine)、テトラメチルヘマトロフィリン(tetramethyl hematoporphyrin)、ローダミン(rhodamine)123;シュードモナスアウルゲジノサエキシトンA(Pseudomonas aeruginosa exotoxin A)に対するIgG2カッパ抗体およびA431エピデモイドカルシノマセル(epidermoid carcinoma cells)と反応するIgG2カッパ抗体、サポリンと共役ノラドレネジックエンジミドーパミンベータ−ハイドロキシラーゼ(noradrenergic enzyme dopamine beta-hydroxylase)に対するモノクロナル抗体;ジーンセラピー剤(gene therapy agents);エナラピル(enalapril)、あるいはこれらのいずれかの混合物の少なくとも1つを含むことを特徴とする請求項1に記載の注入用医療装置。 - 前記対生物作用材料がタクスノールまたはその誘導体である、請求項5記載の注入用医療装置(10)。
- 前記追加のポリマー層(16)は、ポリアミド、パレリンのポリマーまたはその派生物、あるいはビスフェノールAジグリシジル・エーテルおよびアクリル酸あるいはメタクリル酸の光重合可能なモノマーから得られたポリマーから選択された材料である、請求項4記載の注入用医療装置(10)。
- 前記追加のポリマー層(16)の厚さは、5,000−500,000オングストローム(Å)であることを特徴とする請求項7に記載の医療用装置。
- 前記構造体(12)は対生物適合性であり、ステント、脈管あるいは他のグラフト、ステントと組み合わせて用いられる脈管あるいは他のグラフト、心臓バルブ、整形外科用装置、医療装置、注入装置あるいは置換装置、あるいはこれらの一部の少なくとも1つとして構成されることを特徴とする、請求項1記載の注入用医療装置(10)。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US08/484,532 US5609629A (en) | 1995-06-07 | 1995-06-07 | Coated implantable medical device |
US484532 | 1995-06-07 |
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JP16821896A Division JP4684375B2 (ja) | 1995-06-07 | 1996-06-07 | 医療装置 |
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JP16821896A Expired - Lifetime JP4684375B2 (ja) | 1995-06-07 | 1996-06-07 | 医療装置 |
JP2007284885A Expired - Lifetime JP5090130B2 (ja) | 1995-06-07 | 2007-11-01 | 医療装置 |
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JP16821896A Expired - Lifetime JP4684375B2 (ja) | 1995-06-07 | 1996-06-07 | 医療装置 |
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US (2) | US5609629A (ja) |
EP (1) | EP0747069B1 (ja) |
JP (2) | JP4684375B2 (ja) |
KR (1) | KR100478074B1 (ja) |
DE (1) | DE69623855T2 (ja) |
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JP4684375B2 (ja) | 2011-05-18 |
KR970000275A (ko) | 1997-01-21 |
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ES2184838T3 (es) | 2003-04-16 |
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