KR970000275A - 코팅되고 이식가능한 의료 장치 - Google Patents
코팅되고 이식가능한 의료 장치 Download PDFInfo
- Publication number
- KR970000275A KR970000275A KR1019960020190A KR19960020190A KR970000275A KR 970000275 A KR970000275 A KR 970000275A KR 1019960020190 A KR1019960020190 A KR 1019960020190A KR 19960020190 A KR19960020190 A KR 19960020190A KR 970000275 A KR970000275 A KR 970000275A
- Authority
- KR
- South Korea
- Prior art keywords
- bioactive material
- layer
- inhibitors
- bioactive
- stent
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/082—Inorganic materials
- A61L31/088—Other specific inorganic materials not covered by A61L31/084 or A61L31/086
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/10—Inorganic materials
- A61L29/106—Inorganic materials other than carbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/02—Use of inorganic materials
- A61L33/022—Metal or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
- A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
- A61L2300/608—Coatings having two or more layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1002—Intraluminal radiation therapy
Abstract
본 발명은 혈관계, 식도, 기관, 결장, 담도 또는 비뇨관으로 도입되도록 적응시킨 구조물(12); 상기 구조물(12)의 한쪽 표면상에 위치하는 하나이상의 생체활성물질층(18); 및 구조물(12)의 한쪽 표면 및 생체활성물질이 없는 표면상에 위치하는 생체활성물질(18) 위에 위치하는 하나이상의 다공성층(20)을 포함하는, 코팅되고, 코팅되고 이식 가능한 의료장치(10)에 관한 것이다. 구조물(12)은 관상 스텐트인 것이 바람직하다. 다공성층(20)은 기상 또는 플라즈마 증착에 의해 도포되는 것이 바람직한 중합체를 포함하고, 이는 생체활성물질의 조절된 방출을 제공한다. 중합체는 용매, 열 또는 촉매없이 단지 단량체 증기의 축합에 의해 침착된 폴리아미드, 파릴렌 또는 파릴렌 유도체인 것이 특히 바람직하다. 본 발명은 또한 치료에 상기 장치를 사용하는 방법뿐만 아니라 상기 장치(10)의 제조방법에 관한 것이다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명의 바람직한 제1 실시태양의 단면도, 제2도는 본 발명의 바람직한 다른 실시태양의 단면도, 제3도는 본 발명의 바람직한 또 다른 실시태양의 단면도.
Claims (111)
- 환자에게 도입되도록 적응시킨 구조물(12)(이 구조물은 기재물질(14)을 포함함); 상기 구조물(12)의 한쪽 표면상에 위치하는 하나이상의 생체 활성 물질층(18); 및 중합체로 구성되고 생체활성 물질의 조절된 방출을 제공하기에 적절한 두께를 갖는 생체활성 물질층(18)상에 위치하는 하나이상의 다공성층(20)을 포함하는, 이식 가능한 의료장치(10).
- 제1항에 있어서, 하나이상의 다공성층(20)이 무 촉매단량체 증기로부터 중합된 장치(10).
- 제1항에 있어서, 중합체가 폴리아미드, 파틸렌 또는 그의 유도체의 중합체, 폴리(에틸렌 옥사이드), 폴리(에틸렌 글리콜), 폴리(프로필렌 옥사이드), 실리콘 기재 중합체, 메탄, 테트라플루오로에틸렌 또는 테트라메틸디실록산의 중합체 또는 광중합가능한 단량체로부터 유도된 중합체로 이루어진 군으로부터 선택되는 장치(10).
- 제3항에 있어서, 하나이상의 다공성층(20)의 두께가 약 5,000내지 250,000Å인 장치(10).
- 제1항에 있어서, 구조물(12)과 하나이상의 생체활성 물질층(18) 사이의 하나이상의 추가의 코팅층(16)을 포함하는 장치(10).
- 제5항에 있어서, 하나이상의 추가의 코팅층(16)이 하나이상의 다공성층(20)보다 덜 다공성이지만, 상기층과 동일한 중합체 또는 상이한 중합체로 이루어진 장치(10).
- 제6항에 있어서, 중합체가 폴리아미드, 파릴렌 또는 그의 유도체의 중합체 또는 비스페놀 A 디글리시딜 에테르 및 아크릴산 또는 메타크릴산의 광중합가능한 단량체로부터 유도된 중합체로 필수적으로 이루어진 군으로부터 선택되고, 하나이사이의 추가의 코팅층(16)이 약 50,000내지 500,000Å두께인 장치(10).
- 제1항에 있어서, 구조물(12)이 혈관 스텐트로서 배열되는 장치(10).
- 제1항에 있어서, 구조물(12)이 하나이상의 스텐트, 혈관 또는 다른 그래프트, 혈관, 심장판막, 정형외과적 장치, 치과교정장치, 이식물 또는 대체물과 조합한 혈관 또는 기타 그래프트 또는 그의 일부 또는 이들중 임의의 일부로서 배열된 장치(10).
- 제1항에 있어서, 기재물질(14)이 생체적합성인 장치(10).
- 제10항에 있어서, 구조물(12)의 기재물질(14)이 하나이상의 스테인레스 스틸, 탄탈륨, 티탄, 니티놀, 금, 백금, 인코넬, 이리듐, 은, 텅스텐 또는 다른 생체적합성 금속 또는 이들중 임의의 합금; 탄소 또는 탄소 섬유; 셀룰로오스 아세테이트, 셀룰로오스 나이트레이트, 실리콘, 폴리에틸렌 테페프탈레이트, 폴리우레탄, 폴리아미드, 폴리에스테르, 폴리오르토에스테르, 폴리앤하이드라이드, 폴리에테르 술폰, 폴리카르보네이트, 폴리프로필렌, 고분자량 폴리에틸렌, 폴리테트라플루오로에틸렌 또는 다른 생체적합성 중합체 물질 또는 그의 혼합물 및 공중합체, 폴리락트산, 폴리글리콜산 또는 그의 공중합체, 폴리앤하이드라이드, 폴리카프로락톤, 폴리히드록시-부티레이트 발레레이트 또는 다른 생분해성중합체 또는 이들의 혼합물 또는 공중합체; 단백질, 세포외 매트릭스 성분, 콜라겐, 피브린 또는 다른 생물학적 시약; 또는 그의 혼합물을 포함하는 장치(10).
- 제1항에 있어서, 생체활성물질이 하나이상의 헤파린, 공유결합 헤파린 또는 다른 혈전 억제제, 히루딘, 히루로그, 아가트로반, D-페닐알라닐-L-폴리-L-아르기닐 클로로메틸 케톤, 또는 다른 혈전 생성방지제 또는 그의 혼합물, 유로키나제, 스트렙토기나제, 조직 플라스미노겐 활성화제 또는 다른 혈전 분해제 또는 그의 혼합물; 피브린 분해제; 혈관 경련억제제; 칼슘 채널 봉쇄제, 나이트레이트, 산화질소, 산화질소 촉진제 또는 다른 혈관 확장제; 살균제 또는 항생제; 아스피린, 티클로피딘, 글리코프로테인 Ⅱb/Ⅲa 억제제 또는 표면 글리코프로테인 수용체의 다른 억제제 또는 다른 항혈소판제, 콜키신 또는 다른 유사핵분열 방지제 또는 다른 마이크로튜블 억제제, 디메틸슬폭시드(DMSO), 레티노이드 또는 다른 분비억제제, 사이토칼라신 또는 다른 액틴 억제제; 또는 재모델링 억제제; 데옥시리보뉴클레산, 항감작 뉴틀레오티드 또는 분자 유전성 중재를 위한 다른 시약; 매토트렉세이트 또는 다른 항대사산물 또는 증식 방지제; 타목시펜 시트레이트, 탁솔 또는 그의 유도체 또는 다른 항암 화학요법제, 덱사메타손, 덱사메타손 나트륨 포스페이트, 덱사메타손 아세테이트 또는 다른 덱사메타손 유도체 또는 다른 소염 스테로이드 또는 비스테로이드성 소염제; 시클로스포린 또는 다른 면역 억제제; 트라피달(PDGF 길항질), 안지오게닌, 안지오펩틴(성장 호르몬 길항질), 성장 인자 또는 항성장 인자 항체 또는 다른 성장 인자 길항질; 도파민, 브로모크립틴 메실레이트, 퍼골리드 메실레이트 또는 다른 도파민 길항질;80Co,192Ir,32P,111In,90Y,99Tc 또는 다른 방사선 치료제; 요딘 함유 화합물, 바륨 함유화합물, 금, 탄탈륨, 백금, 텅스텐 또는 방사선 불투과성 시약으로서 작용하는 다른 중금속; 펩티드, 단백질, 효소, 세포외 매트릭스 성분, 세포 성분 또는 다른 생물학적 시약; 캡토프릴, 에날라프릴 또는 다른 안지오텐신 전환 효소(ACE)억제제; 아스코르브산, 알파 토코페롤, 수퍼옥사이드 디스뮤타제, 디펙톡사민, 21-아미노 스테로이드(라사로이드) 또는 다른 유리 라디칼 스캐빈저, 이론 킬레이터 또는 항산화제;14C,3H-,131I-,32P- 또는36S-방사선 표시된 형태 또는 상기한 것중 다른 임의의 방사선 표시된 형태; 에스트로겐 또는 다른 성 호르몬; AZT 또는 다른 안티폴리머라제; 아시클로비르, 팜시클로비르, 리만타딘 히드로클로라이드, 간시클로비르 나트륨 또는 다른 항비루스제; 5-아미노레불린산, 메타-테트라히드록시페닐 클로린, 헥사데카플루오로 아연 프탈로시아닌, 테트라메틸 헤마토포르피린, 로다민 123 또는 다른 광역학적 치료제; A431 에피더모이드 종양세포와 반응성인 슈도모나스 아에루기노사 엑소톡신 A에 대한 IgG2 카파 항체, 사포린 또는 다른 항체 타겟 치료제에 콘쥬게이트된 노르아드레날 효소 도파민 베타-히드록실라제 대항하는 모노클로날 항체; 및 에날라프릴 및 다른 전구약물 또는 이들의 임의의 혼합물을 포함하는 장치(10).
- 제1항에 있어서, 하나이상의 생체활성물질층(18)이 구조물(12)의 총 표면적 cm2당 생체활성물질 약0.01내지 4mg을 함유하는 장치(10).
- 제1항에 있어서, 상이한 생체 중합성 물질이 구조물(12)의 상이한 표면상에 위치하는 장치(10).
- 제1항에 있어서, 생체활성물질이 구조물(12)의 한쪽표면상에 위치하고, 다공성층(20)이 구조물(12)의 한쪽 표면상의 생체활성물질(18) 위 및 구조물(12) 생체활성물질이 없는 표면에 위치하는 것이고 제2생체활성물질이 다공성층(20)상에 위치하고 구조물(12)의 최외부층을 형성하는 장치(10).
- 제15항에 있어서, 상이한 제3 생체활성물질이 구조물(12)의 생체활성물질이 없는 측면상에 위치하고, 추가로 제1 및 제3 생체활성물질위에 위치하는 다공성층(20)을 갖는 것이고; 여기서 최외부층을 형성하는 제2 생체활성 물질이 다공성층(20)에 결합된 공유결합 헤파린인 장치(10).
- 제1항에 있어서, 구조물(12)이 상기구조물912)의 한쪽 표면상의 단일 생체활성물질 또는 생체활성물질 또는 물질들 및 다공성층(12)위로 최외부층을 형성하는 상기 제2 생체활성물질위로 다공성층(20)을 갖는 구조물(12)의 상이한 표면상의 상이한 생체활성물질을 포함하는 장치(10).
- 제1항에 있어서, 복수개의 상이한 생체활성물질이 구조물(12)의 상이한 표면상에 위치하고, 단, 동일한 생체활성물질이 동일한 층 내의 구조물912)의 상이한 표면상에 위치하지 않는 것이고, 최외부층이 다공성 층 또는 생체활성물질층을 포함할 수 있는 장치(10).
- 제1항에 있어서, 생체활성물질(18)이 기하학적 패턴의 구조물(12)의 상기 한쪽 표면 상에 위치하는 장치(10).
- 제19항에 있어서, 장치가 스텐트이고, 생체활성물질(18)이 불연속적인 기하학적 패턴의 스텐트의 한쪽 표면상에 위치하는 것인 장치(10).
- 제20항에 있어서, 생체활성물질(18)이 병렬직선패턴의 스텐트의 한쪽 표면상에 위치하는 것이고, 여기서 생체활성물질이 스텐트의 선단부에 위치하지 않는 장치(10).
- 제1항에 있어서, 2개 이상의 상이한 생체활성물질(18)이 구조물(12)의 한쪽 표면상에 위치하는 장치.
- 제22항에 있어서, 2개이상의 상이한 생체활성물질(18)이 구조물(12)의 한쪽 표면에 인접하는 영역상에 위치하는 장치(10).
- 제1항에 있어서, 구조물(12)의 기재물질(14)에 하나이상의 다공성층(12)을 고정시키는 커넥터(26)를 추가로 포함하는 장치(10).
- A. 환자의 혈관 시스템에 도입시키기 위해 사용된, 생체적 합성금속을 포함하는 스텐트 구조물; B, 스텐트 구조물의 한쪽 표면상에 위치하는 하나이상의 생체활성물질; 및 C. 생체활성물질 및 생체활성물질이 없는 스텐트 표면위에 위치하는, 생체활성물질의 조절된 방출을 제공하기에 적절한 약 5,000Å두께인 다공성층을 포함하는, 이식가능한 혈관 장치.
- 제25항에 있어서, 스텐트 표면이 약 50,000Å내지 약 500,000Å의 두께를 갖는 실질적으로 비다공성인 코팅층으로 코팅된 것이고, 코팅층이 폴리아미드, 파릴렌 또는 그의 유도체로부터 유도된 중합체, 폴리알킬렌 옥사이드, 폴리알킬렌 글리콜, 실리콘 기재 중합체, 메탄, 테트라플루오로에틸렌, 테트라메탈디실록산으로부터 유도된 중합체 또는 이러한 중합체의 광중합 가능한 단량체 또는 그의 혼합물 또는 그의 공중합체로부터 유도된 중합체로 필수적으로 이루어진 군으로부터 선택된 중합체를 포함하는 장치.
- 제25항에 있어서, 생체활성물질이 하나 이상의 헤파린, 공유 결합 헤파린 또는 다른 혈전 억제제, 히루딘, 히루로그, 아가트로반, D-페닐알라닐-L-폴리-L-아르기닐 클로로메틸 케톤 또는 다른 혈전 생성 방지제 또는 그의 혼합물; 유로키나제, 스트렙토키나제, 조직 플라스미노겐 활성화제 또는 다른 혈전 분해제 또는 그의 혼합물; 피브린 분해제; 혈관 경련 억제제; 칼슘 채널 봉쇄제, 나이트레이트, 산화질소, 산화질소 촉진제 또는 다른 혈관 확장제; 살균제 또는 항생제; 아스피린, 티클로피딘, 글리코프로테인 Ⅱb/Ⅲa 억제제 또는 표면 글리코프로테인 수용체의 다른 억제제 또는 다른 항혈소판제, 콜키신 또는 다른 유사핵분열 방지제 또는 다른 마이크로튜블 억제제, 디메틸 슬폭시드(DNSO), 레티노이드 또는 다른 분비억제제, 사이토칼라신 또는 다른 액틴 억제제; 또는 재모델링 억제제; 데옥시리보뉴클레산, 항감작 뉴클레오티드 또는 분자 유전성 중재를 위한 다른 시약; 메토트렉세이트 또는 다른 항대사산물 또는 증식 방지제; 타목시펜 시트레이트, 탁솔 또는 그의 유도체 또는 다른 항암 화학요법제, 덱사메타손, 덱사메타손 나트륨 포스페이트, 덱사메타손 아세테이트 또는 다른 덱사메타손 유도체 또는 다른 소염 스테로이드 또는 비스테로이드성 소염제; 시클로스포린 또는 다른 면역 억제제; 트라피달(PDGF 길항질), 안지오펩틴(성장 호르몬 길항질), 안지오게닌, 성장 인자 또는 항성장 인자 항체 또는 다른 성장 인자 길항질; 도파민, 브로모크립틴 메실레이트, 퍼골리드 메실레이트 또는 다른 도파민 길항질;60Co,192Ir,32P,111I,90Y,99Tc 또는 다른 방사선 치료제; 요딘 함유 화합물, 바륨 함유화합물, 금, 탄탈륨, 백금, 텅스텐 또는 방사선 불투과성 시약으로서 작용하는 다른 중금속; 펩티드, 단백질, 효소, 세포외 매트릭스 성분, 세포 성분 또는 다른 생물학적 시약; 캡토프릴, 에날라프릴 또는 다른 안지오텐신 전환 효소(ACE)억제제; 아스코르브산, 알파 토코페롤, 수퍼옥사이드 디스뮤타제, 디펙록사민, 21-아미노 스테로이드(라사로이드) 또는 다른 유리 라디칼 스캐빈저, 이론 킬레이터 또는 항산화제;14C,3H-,131I-,32P- 또는36S-방사선 표지된 형태 또는 상기한 것중 다른 임의의 방사선 표시된 형태; 에스트로겐 또는 다른 성 호르몬; ATZ 또는 다른 안티폴리머라제; 아시클로비르, 팜시클로비르, 리만타딘 히드로클로라이드, 간시클로비르 소듐 또는 다른 항비루스제; 5-마니노레불린산, 메타-테트라히드록시페닐 클로린, 헥사데카플루오르 아연 프탈로시아닌, 테트라메틸 헤바토포르피린, 로다민 123 또는 다른 광역학적 치료제; A431 에피더모이드 종양세포와 반응성인 슈도모나스 아에루기노사 엑소톡신 A에 대한 IgG2 카파 항체, 사포린 또는 다른 항체 타겟 치료제에 콘쥬이트된 노르아드레날 효소 도파민 베타-히드록실라제에 대항하는 모노클로날 항체; 및 에날라프릴 및 다른 전구약물; 유전자 치료제 또는 이들의 임의의 혼합물 및 작은 인테스틴 서브 점막(SIS)의 다양한 형태를 포함하는 장치(10).
- 제25항에 있어서, 하나이상의 생체활성물질층(18)이 구조물(12)의 총 표면적 cm2당 생체활성물질 약 1내지 4mg을 함유하는 장치(10).
- 제25항에 있어서, 상이한 생체 중합성 물질이 스텐트 구조물의 상이한 표면상에 위치하는 장치.
- 제25항에 있어서, 생체활성물질(18)이 스텐트 구조물(12)의 한쪽표면상에 위치하고, 다공성층(20)이 스텐트 구조물(12)의 한쪽표면상의 생체활성물질(18) 위 및 스텐트 구조물(12)의 생체활성물질이 없는 표면 위에 위치하는 것이고 제2생체활성물질이 다공성층(20)상에 위치하고 스텐트 구조물(12)의 최외부층을 형성하는 장치(10).
- 제30항에 있어서, 상이한 제3 생체활성물질(18)이 스텐트 구조물(12)의 생체활성물질이 없는 측면상에 위치하고, 추가로 생체활성물질(18)위에 위치하는 다공성층(20)을 갖는 것이고; 여기서 최외부층을 형성하는 제2 생체 활성물질이 다공성층(20)에 결합된 공유결합 헤파린인 장치.
- 제25항에 있어서, 스텐트 구조물이 상기구조물(12)의 한쪽표면상의 단일 생체활성물질 또는 상기 생체활성물질(18) 또는 물질들(18) 및 다공성층위로 최외부층을 형성하는 상기 제2 생체활성물질위로 다공성층을 갖는 스텐트 구조물(12)의 상이한 표면상의 상이한 생체활성물질(18)을 포함하는 장치.
- 제25항에 있어서, 다중층이 스텐트 표면을 포함하고, 여기서 이러한 층들은 교대하는 다공성 층 및 하나 이상의 생체활성물질층을 포함하고, 상이한 생체활성물질은 스텐트 구조물의 상이한 표면상에 위치하고, 단, 동일한 생체활성물질이 동일한 층 내의 스텐트 구조물의 상이한 표면상에 위치하지 않는 것이고, 다공성층이 각각의 생체 활성물질층위에 위치하고, 최외부층이 다공성층 또는 생체활성물질층을 포함할 수 있는 장치.
- 제25항에 있어서, 생체활성물질(18)이 기하하적 패턴의 스텐트 구조물(12)의 상기 한쪽 표면 상에 위치하는 장치.
- 제34항에 있어서, 생체활성물질(18)이 병렬직선의 패턴 또는 생체활성물질이 스텐트의 선단부에 위치하지 않는 패턴의 스텐트 구조물(12)의 한쪽 표면상에 위치하는 장치.
- 제25항에 있어서, 2개 이상의 상이한 생체활성물질(18)이 스텐트 구조물(12)의 한쪽 표면상에 위치하는 장치.
- 제36항에 있어서, 2개 이상의 상이한 생체활성물질(18)이 스텐트 구조물(12)의 한쪽표면에 인점하는 영역상에 위치하는 장치.
- 하나이상의 생체활성물질층(18)을 구조물의 한쪽표면(12)상에 침착시키는 단계; 및 중합체로 구성되고 생체활성물질의 조절된 방출을 제공하기에 적절한 두께를 가진 하나이상의 다공성층을 하나이상의 생체활성물층(18) 및 구조물(12)의 생체활성물질이 없는 표면위로 침착시키는 선행 단계들을 포함하는, 기재물질(14)을 포함하고 환자에게 도입시키기 위해 적응시킨 구조물(12)을 포함하는 이식가능한 의료장치(10)를 환자에게 삽입하는 단계에 의해 환자를 치료하는 방법.
- 제38항에 있어서, 하나이상의 다공성층(20)이 무촉매단량체 증기로부터 하나이상의 층(20)을 중합시킴으로써 얻은 구조물(12)의 한쪽 표면상에 침착되는 방법.
- 제38항에 있어서, 하나이상의 다공성층(20)이 폴리아미드, 파릴렌의 중합체 또는 그의 유도체, 폴리(에틸렌옥사이드), 폴리(에틸렌 글리콜), 폴리(프로필렌 옥사이드), 실리콘 기재 중합체, 메탄, 테트라플루오로에탄 또는 테트라메틸디실록산의 중합체 또는 광중합성 단량체의 중합체로 필수적으로 이루어진 군으로부터 선택되는 방법.
- 제40항에 있어서, 하나이상의 다공성층(20)이 약 5,000내지 250,000Å의 두께로 도포되는 방법.
- 제38항에 있어서, 구조물(12)과 하나이상의 생체활성물질층(18) 사이의 하나이상의 추가의 코팅층(16)을 침착시키는 단계를 추가로 포함하는 방법.
- 제42항에 있어서, 하나이상의 추가의 코팅층(16)이 하나이상의 다공성층(20)보다 덜 다공성이지만, 상기 층과 동일한 중합체 또는 상이한 중합체를 포함하도록 하나이상의 추가의 코팅층(16)을 침착하는 단계가 수행되는 방법.
- 제43항에 있어서, 하나이상의 추가의 코팅층(16)이 폴리아미드, 파릴렌 또는 파릴렌 유도체로부터 유도된 중합체로 필수적으로 이루어진 군으로부터 선택된 중합체를 포함하고, 하나이상의 추가의 코팅층(16)이 약 50,000내지 50,000Å 두께로 도포되는 방법.
- 제38항에 있어서, 방법이 혈관 스텐트로서 배열된 구조물(12)로 수행된 것이고, 방법이 상이한 층의 침착에 후속하여, 환자의 혈관계로 혈관 스텐트를 삽입하는 단계를 포함하는 방법.
- 제26항에 있어서, 방법이 생체 적합성인 기재물질(14)을 사용하여 수행되는 방법.
- 46항에 있어서, 방법이 기재물질(14)이 하나이상의 스테인레스 스틸, 탄탈륨, 티탄, 니티놀, 금, 백금, 인코넬, 이리듐, 은, 텅스텐 또는 다른 생체 적합성 금속 또는 이들중 임의의 합금; 탄소 또는 탄소 섬유; 셀룰로오스 아세테이트, 셀룰로오스 나이트레이트, 실리콘, 폴리에틸렌 테레프탈레이트, 폴리우레탄, 폴리아미드, 폴리에스테르, 폴리오르토에스테르, 폴리앤하이드라이드, 폴리에테르 술폰, 폴리카르보네이트, 폴리프로필렌, 고분자량폴리에틸렌, 폴리테트라플루오로에틸렌 또는 다른 생체적합성 중합체 물질 또는 그의 혼합물 또는 이들의 공중합체 폴리락트산, 폴리글리콜산 또는 그의 공중합체; 폴리앤하이드라이드, 폴리카프로락톤, 폴리히드록시-부티레이트 발레레이트 또는 다른 생분해성 중합체 또는 이들의 혼합물 또는 공중합체; 단백질, 세포의 매트릭스 성분, 콜라겐, 피브린 또는 다른 생물학적 시약; 또는 그의 혼합물을 포함하는 구조물(12)을 사용하여 수행되는 방법.
- 제26항에 있어서, 하나이상의 생체활성물질(18)을 침착시키는 단계가 하나 이상의 헤파린, 공유 결합 헤파린 또는 다른 혈전 억제제, 히루딘, 히루로그, 아가트로반, D-페닐알라닐-L-폴리-L-아르기닐 클로로메틸 케톤 또는 다른 혈전 생성 방지제 또는 그의 혼합물; 유로키나제, 스트렙토기나제, 조직 플라스미노겐 활성화제 또는 다른 혈전 분해제 또는 그의 혼합물; 피브린 분해제; 혈관 경련 억제제; 칼슘 채널 봉쇄제, 나이트레이트, 산화질소, 산화질소 촉진제 또는 다른 혈관 확장제; 살균제 또는 항생제; 아스피린, 티클로피딘, 글리코프로테인 Ⅱb/Ⅲa 억제제 또는 표면 글리코프로테인 수용체의 다른 억제제 또는 다른 항혈소판제, 콜키신 또는 다른 유사핵분열 방지제 또는 다른 마이크로튜블 억제제, 디메틸 술폭시드(DMSO), 레티노이드 또는 다른 분비억제제, 사이토칼라신 또는 다른 액틴 억제제; 또는 재모델링 억제제; 데옥시리보뉴클레산, 항감작 뉴클레오티드 또는 분자 유전성 중재를 위한 다른 시약; 메토트엑세이트 또는 다른 항대사산물 또는 증식 방지제; 타목시펜 시트레이트, 탁솔 또는 그의 유도체 또는 다른 항암 화학요법제, 덱사메타손, 덱사메타손 소듐 포스페이트, 덱사메타손 아세테이트 또는 다른 덱사메타손 유도체 또는 다른 소염 스테로이드 또는 비스테로이드성 소염제; 시클로스포린 또는 다른 면역 억제제; 트리피달(PDGF 길항질), 안지오펩틴(성장 호르몬 길항질), 안지오게닌, 성장 인자 또는 항성장 인자 항체 또는 다른 성장 인자 길항질; 도파민, 브로코크립틴 메실레이트, 퍼골리드 메실레이트 또는 다른 도파민 길항질;60Co,192Ir,32P,111In,90Y,99Tc 또는 다른 방사선 치료제; 요딘 함유 화합물, 바륨 함유화합물, 금, 탄탈륨, 백금, 텅스텐 또는 방사선 블투과성 시약으로서 작용하는 다른 중금속; 펩티드, 단백질, 효소, 세포의 매트릭스 성분, 세포 성분 또는 다른 생물학적 시약; 캡토프릴, 에날라프릴 또는 다른 안지오텐신 전환 효소(ACE)억제제; 아스코르브산, 알파 토코페롤, 수퍼옥사이드 디스뮤타제, 디페록사민, 21-아미노 스테로이드(라사로이드) 또는 다른 유리 라디칼 스캐빈저, 이론 킬레이터 또는 항산화제;14C,3H-,131I-,32P- 또는36S-방사선 표지된 형태 또는 상기한 것중 다른 임의의 방사선 표시된 형태; 에스트로겐 또는 다른 성 호르몬; AZT 또는 다른 안티폴리머라제; 아시클로비르, 팜시클로비르, 리만타딘 히드로클로라이드, 간시클로비르 나트륨 또는 다른 항비루스제; 5-아미노레불린산, 메타-테트라히드록시페닐 클로린, 헥사데카플루오로 아연 프탈로시아닌, 테트라메틸 헤마토포르피린, 로다민 123 또는 다른 광역학적 치료제; A431 에피더모이드 종양세포와 반응성인 슈도모나스 아에루기노사 엑소톡신 A에 대한 IgG2 카파 항체, 사포린 또는 다른 항체 타겟 치료제에 콘쥬게이트된 노르아드레날 효소 도파민 베타-히드록실라제에 대항하는 모노클로날 항체; 및 에날라프릴 및 다른 전구약물; 유전자 치료제 또는 이들의 임의의 혼합물 및 작은 인테스틴 서브점막(SIS)의 다양한 형태를 포함하는 생체활성물질을 사용하여 수행되는 방법.
- 제38항에 있어서, 하나이상의 생체활성물질층(18)을 침착시키는 단계가 하나이상의 생체활성물질층(18)이 구조물(12)의 총 표면적 cm2당 생체활성물질 약 1내지 4mg을 함유하도록 수행하는 방법.
- 제38항에 있어서, 상이한 생체활성물질이 구조물(12)의 상이한 표면 상에 침착되는 방법.
- 제38항에 있어서, 생체활성물질이 구조물(12)의 한쪽 표면상에 침착되고 다공성층(20)이 구조물(12)의 한쪽표면상의 생체활성물질(18)의 및 구조물(12)의 생체활성물질이 없는 표면위에 위치하는 것이고, 제2 생체활성물질이 다공성층(20)상에 위치하고 구조물(12)의 최외부층을 형성하는 방법.
- 제51항에 있어서, 상이한 제3 생체활성물질이 추가로 상이한 생체활성물질위로 침착된 다공성층(20)을 갖는 구조물(12)의 생체활성물질이 없는 측면 상에 침착되고; 여기서 최외부층을 형성하는 제2 생체활성물질이 다공성층(20)에 결합된 공유 결합 헤파린인 방법.
- 제38항에 있어서, 구조물(12)이 상기 구조물(12)의 한쪽표면상의 단일 생체활성물질 또는 상기 생체물질 또는 물질들 및 다공성층(12) 위로 최외부층을 형성하는 상기 제2 생체활성물질위로 다공성층(20)을 갖는 구조물(12)의 상이한 표면상의 상이한 생체활성물질을 포함하는 방법.
- 제38항에 있어서, 다중 층이 스텐트 표면으로 이루어지고, 여기서 이러한 층들은 교대하는 다공성 층 및 하나 이상의 생체활성물질을 포함하고, 상이한 생체활성물질은 구조물(12)의 상이한 표면상에 위치시키고, 단, 동일한 생체활성물질이 동일한 층 내의 구조물(12)의 두 표면상에 위치하지 않는 것이고, 최외부층이 다공성 층 또는 생체 활성물질층을 포함 할 수 있는 방법.
- 제38항에 있어서, 생체활성물질이 기하학적 패턴의 구조물(12)의 한쪽표면상에 침착되는 방법.
- 제55항에 있어서, 장치가 스텐트이고, 생체활성물질(18)이 불연속적인 기하학적 패턴인 스텐트의 한쪽 표면상에 침착되는 방법.
- 제56항에 있어서, 생체활성물질(18)이 병렬 직선패턴 또는 생체활성물질이 스텐트의 선단부[지류?]상에 위치하지 않는 패턴의 스텐트의 한쪽 표면상에 침착되는 방법.
- 제38항에 있어서, 2개 이상의 상이한 생체활성물질(18)이 스텐트 구조물(12)의 한쪽 측면상에 침착되는 방법.
- 제58항에 있어서, 2개 이상의 생체활성물질(18)이 구조물(12)의 한쪽 표면의 인접 영역상에 침착되는 방법.
- 제38항에 있어서, 장치(10)로 수행하는 방법이 구조물(12)의 기재물질(14)에 하나이상의 다공성층(20)을 고정시키는 커넥터(26)를 추가로 포함하는 방법.
- A. 하나이상의 생체활성물질층(18)을 구조물(12)의 한쪽표면(12)상에 침착시키는 단계; 및 B. 중합체로 구성되고, 생체활성물질의 조절된 방출을 제공하기에 적절한 두께를 가지는 1개 이상의 다공성층(20)을 하나이상의 생체활성물질층(18) 및 구조물 (12)의 생체활성물질이 없는 표면위로 침착시키는 단계를 포함하는, 기재물질(14)을 포함하고 환자에게 도입시키기 위해 적응시킨 구조물(12)를 포함하는 이식가능한 의료장치(10)의 제조방법.
- 제61항에 있어서, 하나이상의 다공성층(20)을 침착시키는 단계가 무 촉매 단량체 증기로부터 하나이상의 층(20)을 중합시키는 단계를 포함하는 방법.
- 제61항에 있어서, 하나이상의 다공성층(20)이 폴리이미드, 파릴렌 또는 그의 유도체로부터 유도된 중합체, 폴리(에틸렌 옥사이드), 폴리(에틸렌 글리콜), 폴리(프로필렌 옥사이드), 실리콘 기재 중합체, 메탄, 테트라플루오로에탄 또는 테트라메틸디실록산의 중합체 또는 광중합 가능한 단량체로부터 유도된 중합체로 필수적으로 이루어진 군으로부터 선택되는 중합체를 포함하는 방법.
- 제64항에 있어서, 생체활성물질(18)이 흡착, 흡수, 기상증착, 플라즈마 침착, 장치 표면으로서의 화학결합, 접착매질로서 계면 활성제의 사용, 전극 위치 또는 그의 조합으로 필수적으로 이루어진 군으로부터 선택된 방법에 의해 침착되는 방법.
- 제64항에 있어서, 생체활성물질(18)이 기상 증착, 플라즈마 침착 또는 기질 구조물(12)에 화학적으로 결합됨으로써 도포되는 것이고, 생체활성물질(18)이 분말, 마이크로 캡슐화된 입자 또는 매트릭스 혼입된 물질의 형태인 방법.
- 제61항에 있어서, 상이한 생체활성물질이 구조물(12)의 상이한 표면상에 침착되는 방법.
- 제61항에 있어서, 제1 생체활성물질이 구조물(12)의 한쪽 표면상에 침착되고, 다공성층(20)이 구조물(12)의 한쪽표면상의 생체활성물질위 및 구조물(12)의 생체활성물질이 없는 표면위에 침착된 것이고, 제2 생체활성물질이 다공성층(20)상에 침착되고 구조물(12)에 대한 최외부층을 형성하는 방법.
- 제67항에 있어서, 상이한 제3 생체활성물질이 구조물(12)의 생체활성물질이 없는 표면상에 침착되고, 이후에 다공성층(20)의 침착 및 다공성층(20)상의 제2의 생체활성물질의 후속하는 침착이 구조물(12)에 대한 최외부층을 형성하는 방법.
- 제61항에 있어서, 다중 층이 구조물(12)의 표면상에 침착되고, 여기서, 이러한 층들은 교대하는 다공성층 및 하나 이상의 생체 활성 물질을 포함하고, 상이한 생체 활성 물질은 구조물(12)의 상이한 표면상에 침착되고, 단, 동일한 생체 활성물질이 동일한 층 내의 구조물(12)의 두 표면 상에 침착되지 않는 것이고, 다공성층이 각각이 생체 활성 물질층 위에 침착되고, 구조물(12)의 최외부층이 다공성층 또는 생체 활성 물질층을 포함할 수 있는 방법.
- 제61항에 있어서, 생체 활성 물질(18)이 기하학적 패턴의 스텐트 구조물(12)의 한쪽 표면상에 침착되는 방법.
- 제70항에 있어서, 장치가 스텐트이고, 생체 활성 물질(18)이 불연속적인 기하학적 패턴의 스텐트의 한쪽 표면상에 침착되는 방법.
- 제71항에 있어서, 생체 활성 물질(18)이 병렬 직선의 패턴 또는 생체 활성 물질이 스텐트의 선단부에 침착되지 않는 패턴의 스텐트의 한쪽 표면상에 침착되고, 생체 활성 물질이 스텐트의 한쪽 표면상에 침착되고, 생체활성물질이 스텐트의 한쪽 표면상에 침착되지 않는 방법.
- 제61항에 있어서, 2개 이상의 생체 활성 물질이 구조물(12)의 한쪽 측면 또는 표면상에 침착되는 방법.
- 제73항에 있어서, 2개 이상의 생체 활성 물질이 구조물(12)의 한족 표면에 인접하는 영역상에 침착되는 방법.
- 제61항에 있어서, 하나 이상의 다공성층(20)이 약5,000내지 250,000Å의 두께로 도포되는 방법.
- 제61항에 있어서, 하나 이상의 다공성층(20)은 디-p-크실렌 또는 그의 유도체를 승화시키거나 또는 분해시킴으로써 단량체성 p-크실렌 또는 그의 유도체를 생성하고, 이렇게 형성된 단량체를 생체 활성 물질층(18) 위로 동시에 축합 및 중합시킴으로써 수행되는 방법.
- 제76항에 있어서, 승화 및 분해 단계가 디클로로-디-p-크실렌으로 수행되는 방법.
- 제61항에 있어서, 하나 이상의 다공성층(20)을 침착시키는 단계가 중합체를 위한 용매 또는 촉매의 부재 하에 수행되는 방법.
- 제61항에 있어서, 하나 이상의 생체 활성 물질층(18)을 침착시키는 단계가 구조물(12) 위에 생체 활성 물질과 유체의 혼합물을 도포하고, 하나 이상의 다공성층(20)을 침착시키는 단계 전에 유체를 제거함으로써 수행되는 방법.
- 제79항에 있어서, 유체가 휘발성이고, 유체 제거 단계가 하나 이상의 다고성층(20)을 침착시키는 단계 이전에 구조물(12) 및 생체 활성 물질로부터 유체를 증발시킴으로써 수행되는 방법.
- 제61항에 있어서, 하나 이상의 추가로 코팅층(16)이 폴리아미드, 파릴렌 또는 파릴렌 유도체로 필수적으로 이루어진 군으로부터 선택된 중합체를 포함하고, 하나 이상의 코팅층(16)이 약 50,000 내지 500,000Å의 두께로 도포되는 방법.
- 제61항에 있어서, 방법이 혈관 스텐트로서 배열된 구조물(12)로 수행되는 방법.
- 제61항에 있어서, 하나 이상의 생체 활성 물질층(18)을 침착시키는 단계가 하나 이상의 헤파린, 공유 경합 헤파린, 또는 다른 혈전 억제제, 히루딘, 히루로그, 아가트로반, D-페닐알리닐-L-폴리-L-아르기닐 클로로메틸 케톤, 또는 다른 혈전 생성 방지제, 또는 그의 혼합물, 유로키나제, 스트렙토키나제, 조직 플라스미노겐 활성화제, 또는 다른 혈전 분해제, 또는 그의 혼합물; 피브린 분해제; 혈관 경련 억제제; 칼슘 채널 봉쇄제, 나이트레이트, 산화질소, 산화질소 촉진제 또는 다른 혈관 확장제; 살균제 또는 항생제; 아스피린, 티클로피딘, 글리코프로테인 Ⅱb/Ⅲa 억제제 또는 표면 그리코프로테인 수용체의 다른 억제제, 또는 다른 항혈소판제, 콜키신 또는 다른 유사핵 분열 방지제, 또는 다른 마이크로튜블 억제제, 디메틸 슬폭시드(DMSO), 레티노이드 또는 다른 분비 억제제, 사이토칼라신 또는 다른 액틴 억제제; 또는 재모델링 억제제; 데옥시리보뉴클레산 항감작 뉴클레오티드 또는 분자 유전성 중재를 위한 다른 시약; 메토트렉세이트 또는 다른 항대사산물 또는 증식 방지제; 타목시펜 시트레이트, 탁솔 또는 그의 유도체, 또는 다른 항암 화학요법제, 덱사메타손, 덱사케타손 나트륨 포스페이트, 덱사메타손 아세테이트 또는 다른 덱사메타손 유도체, 또는 다른 소염 스테로이드 또는 비스테로이드성 소염제; 시클로스포린 또는 다른 면역 억제제; 트라피달(PDGF 길항질), 안지오게닌, 안지오펩틴(성장 호르몬길항질), 성장 인자 또는 항성장 인자 항체, 또는 다른 성장인자 길항질; 도파민, 브로모크립틴 메실레이트, 퍼골리드 메실레이트 또는 다른 도파민 길항질;60Co,192Ir,32P,111In,90Y,99Tc 또는 다른 방사선 치료제; 요딘 함유 화합물, 바륨 함유화합물, 금, 탄탈륨, 백금, 텅스텐 또는 방사선 불투과성 시약으로서 작용하는 다른 중금속; 펩티드, 단백질, 효소, 세포외 메트릭스 성분, 세포 성분 또는 다른 생물학적 시약; 캡토프릴, 에날라프릴 또는 다른 안지오텐신 전환 효소(ACE)억제제; 아스코르브산, 알파 토코페롤, 수퍼옥사이드 디스뮤타제, 디페록사민, 21-아미노 스테로이드(라사로이드) 또는 다른 유리 라디칼 스캐빈저, 이온 킬레이터 또는 황산화제;14C,3H-,131I-,32P-,또는36S-방사선 표지된 형태 또는 상기한 것중 다른 임의의 방사선 표지된 형태; 에스트로겐 또는 다른 성 호르몬; AZT 또는 다른 안티폴리머라제; 아시클로비르 팜시클로비르, 리만타딘 히드로클로라이드, 간시클로비르 나트륨 또는 다른 항비루스제; 5-아미노레불린산, 메타-테트라히드록시페닐클로린, 헥사데카플루오로 아연 프탈로시아닌, 테트라메틸 헤마토포르피린, 로다민 123 또는 다른 광역학적 치료제; A431 에피더모이드 종양 세포와 반응성인 슈도모나스 아에루기노사 엑소톡신 A에 대한 IgG2카파 항체, 사포린 또는 다른 항체 타겟 치료제에 콘쥬게이트된 노르아드레날 효소 도파민 베타-히드록실라제에 대항하는 모노클로날 항체; 및 에날라프릴 및 다른 전구약물 또는 이들의 임의의 혼합물을 포함하는 생체 활성 물질을 사용하여 수행되는 방법.
- 제61항에 있어서, 하나 이상의 생체 활성 물질층(18)을 침착시키는 단계는 하나 이상의 층(18)이 구조물(12)의 총표면적 cm2당 생체 활성 물질 약1내지 4mg을 함유하도록 수행되는 방법.
- 제61항에 있어서, 구조물(12) 위로 하나 이상의 생체 활성 물질층(18)을 침착시키기 전에 기재 물질(14)을 표면처리하는 단계를 추가로 포함하는 방법.
- 환자에게 도입되도록 적응시킨 구조물을 포함하고, 이 구조물은 기재 물질을 포함하고, 여기서, 기재 물질은 물질 표면 내의 개구를 포함하고, 개구 내에 하나 이상의 생체 활성 물질을 함유하고, 여기서 하나 이상의 다공성층이 기재 물질 및 개구 내에 함유된 생체 물질 위에 위치하고, 다공성층은 중합체를 포함하고 생체활성 물질의 조절된 방출을 제공하기에 충분한 두께를 갖는 것인, 이식 가능한 의료 장치.
- 제86항에 있어서, 개구가 호울, 슬롯, 그로브 또는 웰이고, 반원, V자 또는 끝이 잘린 사각형의 절단 형상을 가질 수 있는 장치.
- 제87항에 있어서, 호울, 슬롯, 그로브 또는 웰ㅇ리 포토레지스트 패턴을 사용하여 에칭하거나, 레이저 또는 EBM으로 절단시키거나 또는 스탬핑함으로써 형성될 수 있는 의료 장치.
- 제88항에 있어서, 동일하거나 또는 상이한 생체 활성 물질이 호울, 그로브, 슬롯 또는 웰 내에 함유된 의료 장치.
- 제89항에 있어서, 하나 이상의 생체 활성 물질이 헤파린, 공유 결합 헤파린, 또는 다른 혈전 억제제, 히루딘, 히루로그, 아가크로반, D-페닐알라닐-L-폴리-L-아르기닐 클로로메틸 케톤, 또는 다른 혈전 생성 방지제, 또는 그의 혼합물, 유로키나제, 스트렙토키나제, 조직 플라스미노겐 활성화제, 또는 다른 혈전 분해제, 또는 그의 혼합물; 피브린 분해제; 혈관 경련 억제제; 칼슘 채널 봉쇄제, 나이트레이트, 산화질소, 산화질소 촉진제 또는 다른 혈관 확장제; 살균제 또는 항생제; 아스피린, 티클로피딘, 글리코프로테인 Ⅱb/Ⅲa 억제제 또는 표면 글리코프로테인 수용체의 다른 억제제, 또는 다른 항혈소판제, 콜키신 또는 다른 유산핵분열 방지제, 또는 다른 마이크로튜블 억제제, 디메틸 슬폭시드(DMSO), 레티노이드 또는 다른 분비 억제제, 사이토칼라신 또는 다른 액틴 억제제; 또는 재모델링 억제제; 데옥시리보뉴클레산, 항감작 뉴클레오티드 또는 분자 유전성 중재를 위한 다른 시약; 메토트렉세이트 또는 다른 항대사산물 또는 증식 방지제; 타목시펜 시트레이트, 탁솔 또는 그의 유도체, 또는 다른 항암화학 요법제, 덱사메타손, 덱사메타손 나트륨 포스페이트, 덱사메타손 아세테이트 또는 다른 덱사메타손 유도체 또는 다른 소염 스테로이드 또는 비스테로이드성 소염제; 시클로스포린 또는 다른 면역 억제제; 트라피달(PDGF 길항질), 안지오게닌, 안지오펩틴(성장 호르몬 길항질), 성장 인자 또는 항성장 인자 항체, 또는 다른 성장 인자 길항질; 도파민, 브로모크립틴 메실레이트, 퍼골리드 메실레이트 또는 다른 도파민 길항질;60Co,192Ir,32P,111In,90Y,99Tc 또는 다른 방사선 치료제; 요딘 함유 화합물, 바륨 함유 화합물, 금 탄탈륨, 백금, 텅스텐 또는 방사선 불투과성 시약으로서 작용하는 다른 중금속; 펩티드, 단백질, 효소, 세포외 매트릭스 성분, 세포 성분 또는 다른 생물학적 시약; 캡토프릴, 에날라프릴 또는 다른 안지오텐신 전환 요소(ACE)억제제; 아스코르브산, 알파 토코페롤, 수퍼옥사이드 디스뮤타제, 디페록사민, 21-아미노 스테로이드(라사로이드) 또는 다른 유리라디칼 스캐빈저, 이온 킬레이터 또는 항산화제; C, H-, I-, P- 또는 S-방사선 표지된 형태 또는 상기한 것중 다른 임의의 방사선 표지된 형태; 에스트로겐 또는 다른 성 호르몬; AZT 또는 다른 안티폴리머라제; 아시클로비르, 팜시클로비르, 리만타딘 히드로클로라이드, 간시클로비르 나트륨 또는 다른 항비루스제; 5-아미노레불린산, 메타-테트라히드록시페닐클로린, 헥사데카플루오로 아연 프탈로시아닌, 테트라메틸 헤마토포르피린, 로다민 123 또는 다른 광역학적 치료제; A431 에피더모이드 종양 세포와 반응성인 슈도모나스 아에루기노사 엑소톡신 A에 대한 IgG2 카파 항체, 사포린 또는 다른 항체 타겟 치료제에 콘쥬게이트된 노르아드레날 효소 도파민 베타-히드록실라제에 대항하는 모노클로날 항체; 및 에날라프릴 및 다른 전구약물 또는 이들의 임의의 혼합물로 필수적으로 이루어진 군으로부터 선택되는 의료 장치.
- 제87항에 있어서, 기재 물질이 실질적으로 비다공성 코팅을 포함하고, 다공성 층이 하나 이상의 생체 활성 층을 함유하는 호올, 그로브, 슬롯 또는 웰에 중첩되는 의료 장치.
- 제91항에 있어서, 장치가 생체 활성 물질 층 다공성층 코팅의 추가의 층을 포함하는 의료 장치.
- 기재 물질(14)을 포함하는, 환자에게 도입시키기 위한 구조물(12); 상기 구조물(12)의 한쪽 표면 상에 위치하는 하나 이상의 생체 활성 물질; 및 생체 활성 물질의 조절된 방출을 가능하게 할 수 있는 특성을 갖고 일정 두께인, 생체 활성 물질(18) 상에 위치하는 다공성 층(들)을 포함하는, 이식 가능한 의료 장치(10).
- 제93항에 있어서, 상기 다공성 물질(들)이 중합체성이고, 각각 무 촉매 단량체로부터 중합된 하나 이상의 다공성 충돌(20)로부터 형성되며, 생체 활성 물질 위에 형성되며, 구조물 표면의 임의의 일부가 생체 활성 물질로 코팅되지 않는 장치.
- 제94항에 있어서, 상기 중합체가 폴리아미드, 파릴렌 또는 그의 유도체의 중합체, 폴리알킬렌 옥사이드, 폴리알킬렌 글리콜, 폴리프로필렌 옥사이드, 실리콘 기재 중합체, 메탄, 테트라플루오로에탄 또는 테트라메틸디실록산의 중합체 또는 광중합 가능한 단량체로부터 유도된 중합체로부터 선택되는 것이고/이거나; 또는 구조물(12)의 기재 물질(14)이 하나 이상의 스테인레스 스틸, 탄탈륨, 티탄, 니티놀, 금, 백금, 인코넬, 이리듐, 은, 텅스텐, 또는 다른 생체 적합성 금속, 또는 이들중 임의의 합금; 탄소 또는 탄소 섬유; 셀룰로오스 아세테이트, 셀룰로오스 나이트레이트, 실리콘, 폴리에틸렌 테레프탈레이트, 폴리우레탄, 폴리아미드, 폴리에스테르, 폴리오르토에스테르, 폴리앤하이드라이드, 폴리에테르 술폰, 폴리카르보네이트, 폴리프로필렌, 고분자량 폴리에틸렌, 폴리테트라 플루오로에틸렌, 또는 다른 생체 적합성 중합체 물질, 또는 그의 혼합물 및 공중합체, 폴리락트산, 폴리글리콜산 또는 그의 공중합체, 폴리앤하이드라이드, 폴리카프로락톤, 폴리히드록시-부티레이트 발레레이트 또는 다른 생분해성 중합체, 또는 이들의 혼합물 또는 공중합체; 단백질, 세포외 매트릭스 성분, 클라겐, 피브린 또는 다른 생물학적 시약; 또는 그의 혼합물을 포함하는 것이고; 또는 생체 활성 물질이 하나 이상의 헤파린, 공유 결합 헤파린, 또는 다른 혈전 억제제, 히루딘, 히루로그, 아가트로반, D-페닐알라닐-L-폴리-L-아르기닐 클로로메틸 키톤, 또는 다른 혈전 생성 방지제, 또는 그의 혼합물, 유로키나제, 스트렙토키나제, 조직 플라스미노겐 활성화제, 또는 다른 혈전 분해제, 또는 그의 혼합물; 피브린 분해제, 혈관 경련 억제제; 칼슘 채널 봉쇄제, 나이트레이트, 산화질소, 산화질소 촉진제 또는 다른 혈관 확장제; 살균제 또는 항생제; 아스피린, 티클로피딘, 글리코프로테인 Ⅱb/Ⅲa 억제제 또는 표면 글리코프로테인 수용체의 다른 억제제, 또는 다른 항혈소판재, 콜키신 또는 다른 유사핵분열 방지제, 또는 다른 마이크로튜블 억제제, 디메틸 슬폭시드(DMSO), 레티노이드 또는 다른 분비 억제제, 사이토칼라신 또는 다른 액틴 억제제; 또는 재모델링 억제제; 데옥시리보뉴클레산, 항감작 뉴클레이드 또는 분작 유전성 중재를 위한 다른 시약; 메토르렉세이트 또는 다른 항대사산물 또는 증식 방지제; 타목시펜 시트레이트, 탁솔 또는 그의 유도체, 또는 다른 항암 화학요법제, 덱사메타손, 덱사메타손 나트륨 포스페이트, 덱사메타손 아세테이트 또는 다른 덱사메타손 유도체, 또는 다른 소염 스테로이드 또는 비스테로이드성 소염제; 시클로스포린 또는 다른 면역 억제제; 트라피달(PDGF 길항질), 안지오게닌, 안지오펩틴(성장 호르몬 길항질), 성장 인자 또는 항성장 인자 항체, 또는 다른 성장 인자 길항질; 도파민, 브로모크립틴 메실레이트, 퍼골리드 메실레이트 또는 다른 도파민 길항질80Co,192Ir,32P,111In,90Y,99Tc 또는 다른 방사선 치료제; 요딘 함유 화합물, 바륨 함유 화합물, 금, 탄탈륨, 백금, 텅스텐 또는 방사선 불투과성 시약으로서 작용하는 다른 중금속; 펩티드, 단백질, 효소, 세포외 매트릭스 성분, 세포 성분 또는 다른 생물학적 시약; 캡토프릴, 에날라프릴 또는 다른 안지오텐신 전환 효소(ACE)억제제; 아스코르브산, 알파 토코페롤, 수퍼옥사이드 디스뮤타제, 디페록사민, 21-아미노 스테로이드(라사로이드) 또는 다른 유리 라디칼 스캐빈저, 이온 킬레이터 또는 항산화제;14C,3H-,131I-,32P-, 또는36S-방사선 표지된 형태 또는 상기한 것중 다른 임의의 방사선 표지된 형태; 에스트로겐 또는 다른 성 호르몬; AZT 또는 다른 안티폴리머라제; 아시클로비르, 팜시클로비르, 리만타딘 히드로클로라이드, 간시클로비르 나트륨 또는 다른 항비루스제; 5-아미노레불린산, 메타-테트라히드록시페닐 클로린, 헥사데카플루오르 아연 프탈로시아닌, 테트라메틸 헤마토포르피린, 로다민 123 또는 다른 광역학적 치료제; A431 에피더모이드 종양 세포와 반응성인 슈도모나스 아에루기노사 엑소톡신 A에 대한 IgG2 카파 항체, 사포린 또는 다른 항체 타겟 치료제에 콘쥬게이트된 노르아드레날 효소 도파민 베타-히드록실라제에 대항하는 모노클로날 항체; 유전자 치료제; 및 에날라프릴 및 다른 전구약물 또는 이들의 임의의 혼합물을 포함하는 장치.
- 제94항 또는 제95항에 있어서, 하나 이상의 다공성층(20)의 두께가 약 5,000내지 250,000Å이고, 생체 활성물질(들)이, 예를 들면 cm2당 약 1내지 4mg으로 존재하는 장치(10).
- 제93항 내지 제96항 중의 어느 한 항에 있어서, 하나 이상의 추가의 코팅 층, 예를 들면 구조물(12)과 하나 이상의 생체 활성 물질층(18) 사이의 다소 또는 실질적으로 비다공성인 중합체층(16)을 포함하는 장치.
- 제97항에 있어서, 추가의 코팅 층의 중합체가 폴리아미드, 파릴렌 또는 그의유도체의 중합체, 또는 비스페놀A 디글리시딜 에테르 및 아크릴산 또는 메타크릴산의 광중합 가능한 단량체로부터 유도된 중합체로부터 선택되는 것이고, 하나 이상의 추가의 코팅층(16)이 약 50,000내지 500,000Å 두께인 장치(10).
- 제93항에 있어서, 구조물(12)이 생체 적합성이고, 하나 이상의 스텐트, 혈관 또는 다른 그래프트, 스텐트, 심장 판막, 또는 정형외과적 장치, 치과 교정 장치, 이식물 또는 대체물과 조합한 혈관 또는 기타 그래프트 또는 그의 일부 또는 이들 중 임의의 일부로서 배열된 장치(10).
- 제93항에 있어서, 상기 상이한 생체 활성 물질이 구조물의 한쪽 표면 또는 측면 상의 상이한 위치에 위치하고, 구조물 상에 또는 그 내부에 직접적으로 형성되거나 또는 하나의 위치의 구조물 상에 또는 그 내부에 부분적으로 및 다른 위치의 다공성층 상에 부분적으로 형성되는 장치(10).
- 제100항에 있어서, 제3의 상이한 생체 활성 물질이 구조물의 다른 측면 상에 또는 그 내부에 위치하고, 다공성층이 상기 제3의 또는 상이한 물질 위에 위치하고, 또한 구조물의 한쪽 측면 상의 하나의 생체 활성 물질 위에 위치하는 것이고, 다른 생체 물질, 예를 들면 공유 결합 헤파린이 다공성 층의 외부 표면에 결합된 장치(10).
- 제93항 내지 제101항중의 어느 한 항에 있어서, 생체 활성 물질(들)(18)이 기하학적 패턴, 또는 구조물이 스텐트일 때 불연속적인 기하학적 패턴 또는 병렬 직선의 패턴, 또는 스텐트의 선단부 상에서가 아닌 병렬 직선의 패턴으로 상기 구조물의 한쪽 부분 또는 표면 상에 위치하거나, 또는 구조물(12)의 동일한 표면의 인접한 부분 상에 또는 그 내부에 위치하는 장치(10).
- 제93항 내지 제102항 중의 어느 한 항에 있어서, 구조물(12)의 기재 물질(14)에 하나 이상의 다공성층(20)을 고정시키는 커넥터(26)를 추가로 포함하는 장치(10).
- 제101항 내지 제103항 중의 어느 한 항에 있어서, 구조물, 예를 들면 스텐트가 약 50,000Å 내지 약 500,000Å의 두께를 갖는 실질적으로 바다공성인 코팅 층으로 표면 코팅된 것이고, 코팅 층이 폴리아미드, 파릴렌 또는 그의 유도체로부터 유도된 중합체, 폴리알킬렌 옥사이드, 폴리알킬렌 글리콜, 실리콘 기재 중합체, 메탄, 테트라플루오로에틸렌, 테트라메틸리실록산으로부터 유도된 중합체 또는 광중합 가능한 단량체로부터 유도된 중합체 또는 이들 중합체의 혼합물 또는 그의 공중합체로부터 선택된 중합체를 포함하는 장치.
- 제100항 또는 제101항에 있어서, 다중 층이 스텐트 표면을 포함하고, 이러한 층들이 교대하는 다공성 충들 및 하나 이상의 생체 활성 물질층을 포함하고, 상이한 생체 활성 물질이 스텐트 구조물의 상이한 표면 상에 위치하는 것이고, 단, 동일한 생체 활성 물질이 동일한 층 내부의 스텐트 구조물의 상이한 표면 상에 위치하지 않는 것이고, 다공성 층이 각각의 생체 활성 물질 층 위에 위치하고, 최외부 층이 다공성 층 또는 생체 활성 물질 층을 포함할 수 있는 장치.
- 생체 활성 물질층(18)이 흡착, 흡수, 기상 증착, 플라즈마 침착, 장치 표면으로의 화학 결합, 접착 매질로서 계면 활성제의 사용, 전극 위치 또는 그의 조합으로 이루어진 방법에 의해 위치되는 제93항 내지 제105항 중의 어느한 항에 따르는 장치의 제조 방법.
- 제106항에 있어서, 생체 활성 물질층(18)이 기상 증착, 플라즈마 침착 또는 기질 구조물(12)에 화학적으로 결합됨으로써 도포되는 것이고, 생체 활성 물질(18)이 분말, 마이크로 캡슐화된 입자 또는 매트릭스 혼입된 물질의 형태인 방법.
- 하나 이상의 다공성층(20)이 디-p-크실렌 또는 그의 유도체를 승화시키거나 또는 열분해시킴으로써 단량체를 생성하고, 예를 들면, 승화 열분해 단계가 디클로로-디-p-크실렌으로 수행되고, 이렇게 형성된 단량체를 생체활성 물질층(18) 위로 동시에 축합 및 중합시킴으로써 형성되는 제93항 내지 제98항 내지 제107항 중의 어느 한 항에 따르는 장치의 제조 방법.
- 제108항에 있어서, 하나 이상의 생체 활성 물질층(18)을 침착시키는 단계가 구조물(12) 위에 생체 활성 물질과 유체의 혼합물을 도포하고, 하나 이상의 다공성층(20)을 침착시키는 단계 전에 유체를 제거함으로써 수행되는 방법.
- 제109항에 있어서, 유체가 휘발성이고, 유체 제거 단계가 하나 이상의 다공성층(20)을 침착시키는 단계 이전에 구조물(12) 및 생체 활성 물질로부터 유체를 증발시킴으로써 수행되는 방법.
- 제93항 내지 제105항 중의 한 항에 있어서, 기재 물질이 기재 물질의 표면 내부의 개구를 포함하고, 생체 활성 물질(들)이 개구 내에 위치하는 것이고, 개구가 호올, 슬롯, 그로브 또는 웰 등의 형태이고, 예를 들면 반원, V자형, 또는 끝이 잘린 사각형의 에칭 또는 스탬핑된 절단 형상을 갖는 것이고, 동일하거나, 또는 상이한 생체 활성 물질이 호울, 그로브, 슬롯 또는 웰 내에 함유되는 장치.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/484,532 | 1995-06-07 | ||
US08/484,532 US5609629A (en) | 1995-06-07 | 1995-06-07 | Coated implantable medical device |
US08/645,646 | 1996-05-16 | ||
US08/645,646 US6096070A (en) | 1995-06-07 | 1996-05-16 | Coated implantable medical device |
Publications (2)
Publication Number | Publication Date |
---|---|
KR970000275A true KR970000275A (ko) | 1997-01-21 |
KR100478074B1 KR100478074B1 (ko) | 2005-09-15 |
Family
ID=23924541
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019960020190A KR100478074B1 (ko) | 1995-06-07 | 1996-06-07 | 피복되고이식가능한의료장치 |
Country Status (7)
Country | Link |
---|---|
US (2) | US5609629A (ko) |
EP (1) | EP0747069B1 (ko) |
JP (2) | JP4684375B2 (ko) |
KR (1) | KR100478074B1 (ko) |
DE (1) | DE69623855T2 (ko) |
DK (1) | DK0747069T3 (ko) |
ES (1) | ES2184838T3 (ko) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100356643B1 (ko) * | 2000-03-31 | 2002-10-18 | 한국과학기술연구원 | 생리활성 물질이 결합된 생체적합성 의료용 금속 재료 및이의 제조 방법 |
KR100491700B1 (ko) * | 2002-03-22 | 2005-05-27 | 주식회사 뉴하트바이오 | 플라즈마 공정을 이용하여 ptfe 표면에 항혈전단백질을 고정화하는 방법 |
Families Citing this family (1274)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5843089A (en) * | 1990-12-28 | 1998-12-01 | Boston Scientific Corporation | Stent lining |
CA2063529A1 (en) * | 1991-03-22 | 1992-09-23 | Katsuro Tachibana | Booster for therapy of diseases with ultrasound and pharmaceutical liquid composition containing the same |
US5811447A (en) | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US6497709B1 (en) | 1992-03-31 | 2002-12-24 | Boston Scientific Corporation | Metal medical device |
JPH07505316A (ja) | 1992-03-31 | 1995-06-15 | ボストン サイエンティフィック コーポレーション | 医療用ワイヤ |
US7101392B2 (en) * | 1992-03-31 | 2006-09-05 | Boston Scientific Corporation | Tubular medical endoprostheses |
US5630840A (en) | 1993-01-19 | 1997-05-20 | Schneider (Usa) Inc | Clad composite stent |
US20050059889A1 (en) * | 1996-10-16 | 2005-03-17 | Schneider (Usa) Inc., A Minnesota Corporation | Clad composite stent |
US6491938B2 (en) | 1993-05-13 | 2002-12-10 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US6663881B2 (en) | 1993-01-28 | 2003-12-16 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5981568A (en) | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US20070122465A1 (en) * | 1993-02-22 | 2007-05-31 | Desai Neil P | Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
US5824048A (en) * | 1993-04-26 | 1998-10-20 | Medtronic, Inc. | Method for delivering a therapeutic substance to a body lumen |
US20020055710A1 (en) * | 1998-04-30 | 2002-05-09 | Ronald J. Tuch | Medical device for delivering a therapeutic agent and method of preparation |
US5505713A (en) * | 1994-04-01 | 1996-04-09 | Minimed Inc. | Indwelling catheter with stable enzyme coating |
US20030086975A1 (en) * | 2001-11-08 | 2003-05-08 | Timothy Ringeisen | Method for making a porous Polymeric material |
US8697108B2 (en) * | 1994-05-13 | 2014-04-15 | Kensey Nash Corporation | Method for making a porous polymeric material |
FR2722413B1 (fr) * | 1994-07-13 | 1997-02-07 | Marian Devonec | Implant therapeutique destine au traitement cytoreducteur selectif de l'obstruction d'une lumiere ou voie naturelle d'un corps humain ou animal |
US6231600B1 (en) | 1995-02-22 | 2001-05-15 | Scimed Life Systems, Inc. | Stents with hybrid coating for medical devices |
US6558798B2 (en) | 1995-02-22 | 2003-05-06 | Scimed Life Systems, Inc. | Hydrophilic coating and substrates coated therewith having enhanced durability and lubricity |
DE19508772C2 (de) | 1995-03-01 | 1998-01-29 | Schering Ag | Verfahren und Verbindungen zur Detektion von Analyten mittels Remanenzmessung und deren Verwendung |
US20020091433A1 (en) * | 1995-04-19 | 2002-07-11 | Ni Ding | Drug release coated stent |
US5837313A (en) | 1995-04-19 | 1998-11-17 | Schneider (Usa) Inc | Drug release stent coating process |
US6099562A (en) * | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
US5820917A (en) * | 1995-06-07 | 1998-10-13 | Medtronic, Inc. | Blood-contacting medical device and method |
US20070203520A1 (en) * | 1995-06-07 | 2007-08-30 | Dennis Griffin | Endovascular filter |
US7550005B2 (en) * | 1995-06-07 | 2009-06-23 | Cook Incorporated | Coated implantable medical device |
US7896914B2 (en) * | 1995-06-07 | 2011-03-01 | Cook Incorporated | Coated implantable medical device |
US6774278B1 (en) * | 1995-06-07 | 2004-08-10 | Cook Incorporated | Coated implantable medical device |
CA2178541C (en) * | 1995-06-07 | 2009-11-24 | Neal E. Fearnot | Implantable medical device |
US7867275B2 (en) * | 1995-06-07 | 2011-01-11 | Cook Incorporated | Coated implantable medical device method |
US7846202B2 (en) | 1995-06-07 | 2010-12-07 | Cook Incorporated | Coated implantable medical device |
US20020193828A1 (en) * | 2001-06-14 | 2002-12-19 | Cook Incorporated | Endovascular filter |
WO1998017331A1 (en) * | 1995-06-07 | 1998-04-30 | Cook Incorporated | Silver implantable medical device |
US7611533B2 (en) * | 1995-06-07 | 2009-11-03 | Cook Incorporated | Coated implantable medical device |
US6558686B1 (en) | 1995-11-08 | 2003-05-06 | Baylor College Of Medicine | Method of coating medical devices with a combination of antiseptics and antiseptic coating therefor |
US5756145A (en) * | 1995-11-08 | 1998-05-26 | Baylor College Of Medicine | Durable, Resilient and effective antimicrobial coating for medical devices and method of coating therefor |
US5855602A (en) * | 1996-09-09 | 1999-01-05 | Shelhigh, Inc. | Heart valve prosthesis |
US6783543B2 (en) * | 2000-06-05 | 2004-08-31 | Scimed Life Systems, Inc. | Intravascular stent with increasing coating retaining capacity |
US6110155A (en) * | 1996-04-30 | 2000-08-29 | Medtronic, Inc. | Anti-inflammatory-agent-loaded catheter and method for preventing tissue fibrosis |
US5951586A (en) * | 1996-05-15 | 1999-09-14 | Medtronic, Inc. | Intraluminal stent |
WO1997045105A1 (en) | 1996-05-24 | 1997-12-04 | Angiotech Pharmaceuticals, Inc. | Compositions and methods for treating or preventing diseases of body passageways |
US20060052757A1 (en) * | 1996-06-04 | 2006-03-09 | Vance Products Incorporated, D/B/A Cook Urological Incorporated | Implantable medical device with analgesic or anesthetic |
US20060025726A1 (en) * | 1996-06-04 | 2006-02-02 | Vance Products Incorporated, D/B/A Cook Urological Incorporated | Implantable medical device with pharmacologically active layer |
US20060030826A1 (en) * | 1996-06-04 | 2006-02-09 | Vance Products Incorporated,d/b/a Cook Urological Incorporated | Implantable medical device with anti-neoplastic drug |
US6666883B1 (en) | 1996-06-06 | 2003-12-23 | Jacques Seguin | Endoprosthesis for vascular bifurcation |
US7070590B1 (en) * | 1996-07-02 | 2006-07-04 | Massachusetts Institute Of Technology | Microchip drug delivery devices |
US5871436A (en) * | 1996-07-19 | 1999-02-16 | Advanced Cardiovascular Systems, Inc. | Radiation therapy method and device |
US6174329B1 (en) * | 1996-08-22 | 2001-01-16 | Advanced Cardiovascular Systems, Inc. | Protective coating for a stent with intermediate radiopaque coating |
US5924973A (en) * | 1996-09-26 | 1999-07-20 | The Trustees Of Columbia University In The City Of New York | Method of treating a disease process in a luminal structure |
US6443942B2 (en) | 1996-11-01 | 2002-09-03 | Minimed, Inc. | Medication device with protein stabilizing surface coating |
US7341598B2 (en) | 1999-01-13 | 2008-03-11 | Boston Scientific Scimed, Inc. | Stent with protruding branch portion for bifurcated vessels |
ATE539702T1 (de) * | 1996-11-04 | 2012-01-15 | Advanced Stent Tech Inc | Vorrichtung zum ausdehnnen eines stents und verfahren zu seiner entfaltung |
US6835203B1 (en) * | 1996-11-04 | 2004-12-28 | Advanced Stent Technologies, Inc. | Extendible stent apparatus |
US6692483B2 (en) | 1996-11-04 | 2004-02-17 | Advanced Stent Technologies, Inc. | Catheter with attached flexible side sheath |
US6599316B2 (en) * | 1996-11-04 | 2003-07-29 | Advanced Stent Technologies, Inc. | Extendible stent apparatus |
US8211167B2 (en) | 1999-12-06 | 2012-07-03 | Boston Scientific Scimed, Inc. | Method of using a catheter with attached flexible side sheath |
US7591846B2 (en) * | 1996-11-04 | 2009-09-22 | Boston Scientific Scimed, Inc. | Methods for deploying stents in bifurcations |
US6325826B1 (en) * | 1998-01-14 | 2001-12-04 | Advanced Stent Technologies, Inc. | Extendible stent apparatus |
US7220275B2 (en) * | 1996-11-04 | 2007-05-22 | Advanced Stent Technologies, Inc. | Stent with protruding branch portion for bifurcated vessels |
US20050163818A1 (en) * | 1996-11-05 | 2005-07-28 | Hsing-Wen Sung | Drug-eluting device chemically treated with genipin |
IT1289815B1 (it) * | 1996-12-30 | 1998-10-16 | Sorin Biomedica Cardio Spa | Stent per angioplastica e relativo procedimento di produzione |
US5873811A (en) * | 1997-01-10 | 1999-02-23 | Sci-Med Life Systems | Composition containing a radioactive component for treatment of vessel wall |
US6808250B2 (en) * | 1997-01-10 | 2004-10-26 | Konica Corporation | Production method of ink-jet head |
US8663311B2 (en) * | 1997-01-24 | 2014-03-04 | Celonova Stent, Inc. | Device comprising biodegradable bistable or multistable cells and methods of use |
US6491619B1 (en) * | 1997-01-31 | 2002-12-10 | Endologix, Inc | Radiation delivery catheters and dosimetry methods |
JP4422215B2 (ja) * | 1997-02-20 | 2010-02-24 | クック インコーポレイテッド | 被覆された移植可能な医療器具 |
US7885697B2 (en) | 2004-07-13 | 2011-02-08 | Dexcom, Inc. | Transcutaneous analyte sensor |
US20050033132A1 (en) | 1997-03-04 | 2005-02-10 | Shults Mark C. | Analyte measuring device |
US10028851B2 (en) | 1997-04-15 | 2018-07-24 | Advanced Cardiovascular Systems, Inc. | Coatings for controlling erosion of a substrate of an implantable medical device |
US6240616B1 (en) | 1997-04-15 | 2001-06-05 | Advanced Cardiovascular Systems, Inc. | Method of manufacturing a medicated porous metal prosthesis |
US8172897B2 (en) | 1997-04-15 | 2012-05-08 | Advanced Cardiovascular Systems, Inc. | Polymer and metal composite implantable medical devices |
US6273913B1 (en) | 1997-04-18 | 2001-08-14 | Cordis Corporation | Modified stent useful for delivery of drugs along stent strut |
US8790391B2 (en) * | 1997-04-18 | 2014-07-29 | Cordis Corporation | Methods and devices for delivering therapeutic agents to target vessels |
US6776792B1 (en) | 1997-04-24 | 2004-08-17 | Advanced Cardiovascular Systems Inc. | Coated endovascular stent |
DE19718339A1 (de) * | 1997-04-30 | 1998-11-12 | Schering Ag | Polymer beschichtete Stents, Verfahren zu ihrer Herstellung und ihre Verwendung zur Restenoseprophylaxe |
US6582392B1 (en) | 1998-05-01 | 2003-06-24 | Ekos Corporation | Ultrasound assembly for use with a catheter |
US6676626B1 (en) * | 1998-05-01 | 2004-01-13 | Ekos Corporation | Ultrasound assembly with increased efficacy |
US6056993A (en) * | 1997-05-30 | 2000-05-02 | Schneider (Usa) Inc. | Porous protheses and methods for making the same wherein the protheses are formed by spraying water soluble and water insoluble fibers onto a rotating mandrel |
US6433154B1 (en) * | 1997-06-12 | 2002-08-13 | Bristol-Myers Squibb Company | Functional receptor/kinase chimera in yeast cells |
US6149581A (en) * | 1997-06-12 | 2000-11-21 | Klingenstein; Ralph James | Device and method for access to the colon and small bowel of a patient |
US6106454A (en) * | 1997-06-17 | 2000-08-22 | Medtronic, Inc. | Medical device for delivering localized radiation |
US6203536B1 (en) * | 1997-06-17 | 2001-03-20 | Medtronic, Inc. | Medical device for delivering a therapeutic substance and method therefor |
CN100462066C (zh) * | 1997-06-27 | 2009-02-18 | 美国生物科学有限公司 | 药剂的新制剂及其制备和应用方法 |
US20030199425A1 (en) * | 1997-06-27 | 2003-10-23 | Desai Neil P. | Compositions and methods for treatment of hyperplasia |
DE19729279A1 (de) | 1997-07-09 | 1999-01-14 | Peter Hildebrandt | Urologisches Implantat, insbesondere Gefäßwandstütze für den Urinaltrakt |
FR2766092B1 (fr) * | 1997-07-16 | 1999-10-08 | Centre Nat Rech Scient | Dispositif implantable recouvert d'un polymere capable de liberer des substances biologiquement actives |
US6306166B1 (en) | 1997-08-13 | 2001-10-23 | Scimed Life Systems, Inc. | Loading and release of water-insoluble drugs |
US6156061A (en) * | 1997-08-29 | 2000-12-05 | Target Therapeutics, Inc. | Fast-detaching electrically insulated implant |
US6476070B2 (en) | 1997-09-11 | 2002-11-05 | Provasis Therapeutics Inc. | Compositions useful for remodeling body spaces |
US6538026B1 (en) | 1997-09-11 | 2003-03-25 | Provasis Therapeutics, Inc. | Compositions useful for remodeling body spaces |
US6890546B2 (en) * | 1998-09-24 | 2005-05-10 | Abbott Laboratories | Medical devices containing rapamycin analogs |
US7399480B2 (en) * | 1997-09-26 | 2008-07-15 | Abbott Laboratories | Methods of administering tetrazole-containing rapamycin analogs with other therapeutic substances using medical devices |
US20030129215A1 (en) * | 1998-09-24 | 2003-07-10 | T-Ram, Inc. | Medical devices containing rapamycin analogs |
US6129705A (en) * | 1997-10-01 | 2000-10-10 | Medtronic Ave, Inc. | Drug delivery and gene therapy delivery system |
US7637948B2 (en) | 1997-10-10 | 2009-12-29 | Senorx, Inc. | Tissue marking implant |
US8668737B2 (en) | 1997-10-10 | 2014-03-11 | Senorx, Inc. | Tissue marking implant |
ATE248615T1 (de) * | 1997-10-31 | 2003-09-15 | Childrens Medical Center | Blasenrekonstruktion |
EP1059979A4 (en) | 1997-11-07 | 2001-05-30 | California Inst Of Techn | MICRO-MADE PARTICLE FILTER MEMBRANE WITH PARYLENE REINFORCEMENT |
US6270464B1 (en) | 1998-06-22 | 2001-08-07 | Artemis Medical, Inc. | Biopsy localization method and device |
US6331191B1 (en) * | 1997-11-25 | 2001-12-18 | Trivascular Inc. | Layered endovascular graft |
US5976169A (en) * | 1997-12-16 | 1999-11-02 | Cardiovasc, Inc. | Stent with silver coating and method |
US6395019B2 (en) | 1998-02-09 | 2002-05-28 | Trivascular, Inc. | Endovascular graft |
US7179289B2 (en) * | 1998-03-30 | 2007-02-20 | Conor Medsystems, Inc. | Expandable medical device for delivery of beneficial agent |
EP1222941B2 (en) † | 1998-03-30 | 2009-04-22 | Conor Medsystems, Inc. | Flexible medical device |
US20040254635A1 (en) * | 1998-03-30 | 2004-12-16 | Shanley John F. | Expandable medical device for delivery of beneficial agent |
US6241762B1 (en) | 1998-03-30 | 2001-06-05 | Conor Medsystems, Inc. | Expandable medical device with ductile hinges |
US7208011B2 (en) * | 2001-08-20 | 2007-04-24 | Conor Medsystems, Inc. | Implantable medical device with drug filled holes |
US7208010B2 (en) * | 2000-10-16 | 2007-04-24 | Conor Medsystems, Inc. | Expandable medical device for delivery of beneficial agent |
US7713297B2 (en) | 1998-04-11 | 2010-05-11 | Boston Scientific Scimed, Inc. | Drug-releasing stent with ceramic-containing layer |
US20030040790A1 (en) * | 1998-04-15 | 2003-02-27 | Furst Joseph G. | Stent coating |
US20020099438A1 (en) * | 1998-04-15 | 2002-07-25 | Furst Joseph G. | Irradiated stent coating |
US8029561B1 (en) | 2000-05-12 | 2011-10-04 | Cordis Corporation | Drug combination useful for prevention of restenosis |
US20070087028A1 (en) * | 1998-04-16 | 2007-04-19 | Robert Falotico | Intraluminal devices for the prevention and treatment of vascular disease |
WO1999053994A1 (en) | 1998-04-20 | 1999-10-28 | Medtronic, Inc. | Medical leads with enhanced biocompatibility and biostability |
US7658727B1 (en) * | 1998-04-20 | 2010-02-09 | Medtronic, Inc | Implantable medical device with enhanced biocompatibility and biostability |
WO1999055396A1 (en) * | 1998-04-27 | 1999-11-04 | Surmodics, Inc. | Bioactive agent release coating |
US6013099A (en) | 1998-04-29 | 2000-01-11 | Medtronic, Inc. | Medical device for delivering a water-insoluble therapeutic salt or substance |
EP1082072B8 (en) | 1998-06-04 | 2014-03-05 | New York University | Endovascular thin film devices for treating and preventing stroke |
US6203505B1 (en) * | 1998-06-05 | 2001-03-20 | Advanced Cardiovascular Systems, Inc. | Guidewires having a vapor deposited primer coat |
US20020087184A1 (en) * | 1998-06-18 | 2002-07-04 | Eder Joseph C. | Water-soluble coating for bioactive devices |
US6652581B1 (en) * | 1998-07-07 | 2003-11-25 | Boston Scientific Scimed, Inc. | Medical device with porous surface for controlled drug release and method of making the same |
US7967855B2 (en) * | 1998-07-27 | 2011-06-28 | Icon Interventional Systems, Inc. | Coated medical device |
US8070796B2 (en) * | 1998-07-27 | 2011-12-06 | Icon Interventional Systems, Inc. | Thrombosis inhibiting graft |
US6273875B1 (en) | 1998-08-17 | 2001-08-14 | Edwards Lifesciences Corporation | Medical devices having improved antimicrobial/antithrombogenic properties |
AU771367B2 (en) * | 1998-08-20 | 2004-03-18 | Cook Medical Technologies Llc | Coated implantable medical device |
DE19838183A1 (de) * | 1998-08-21 | 2000-03-09 | Alexei Kalatchev | Verfahren zur Herstellung von Gegenständen mit einer gekapselten Radioaktivität, insbesondere bei medizinischen Implantaten |
US6248127B1 (en) | 1998-08-21 | 2001-06-19 | Medtronic Ave, Inc. | Thromboresistant coated medical device |
US6335029B1 (en) * | 1998-08-28 | 2002-01-01 | Scimed Life Systems, Inc. | Polymeric coatings for controlled delivery of active agents |
US7455853B2 (en) * | 1998-09-24 | 2008-11-25 | Abbott Cardiovascular Systems Inc. | Medical devices containing rapamycin analogs |
US20040043068A1 (en) * | 1998-09-29 | 2004-03-04 | Eugene Tedeschi | Uses for medical devices having a lubricious, nitric oxide-releasing coating |
US6340368B1 (en) | 1998-10-23 | 2002-01-22 | Medtronic Inc. | Implantable device with radiopaque ends |
US6293967B1 (en) | 1998-10-29 | 2001-09-25 | Conor Medsystems, Inc. | Expandable medical device with ductile hinges |
US20030099682A1 (en) * | 1998-11-20 | 2003-05-29 | Francis Moussy | Apparatus and method for control of tissue/implant interactions |
WO2000032250A1 (en) | 1998-12-01 | 2000-06-08 | Cook Biotech, Inc. | A multi-formed collagenous biomaterial medical device |
US8382821B2 (en) | 1998-12-03 | 2013-02-26 | Medinol Ltd. | Helical hybrid stent |
US20040267349A1 (en) | 2003-06-27 | 2004-12-30 | Kobi Richter | Amorphous metal alloy medical devices |
US6120847A (en) * | 1999-01-08 | 2000-09-19 | Scimed Life Systems, Inc. | Surface treatment method for stent coating |
US7655030B2 (en) | 2003-07-18 | 2010-02-02 | Boston Scientific Scimed, Inc. | Catheter balloon systems and methods |
US20050060027A1 (en) * | 1999-01-13 | 2005-03-17 | Advanced Stent Technologies, Inc. | Catheter balloon systems and methods |
US6725083B1 (en) | 1999-02-02 | 2004-04-20 | Senorx, Inc. | Tissue site markers for in VIVO imaging |
US7651505B2 (en) | 2002-06-17 | 2010-01-26 | Senorx, Inc. | Plugged tip delivery for marker placement |
US9820824B2 (en) | 1999-02-02 | 2017-11-21 | Senorx, Inc. | Deployment of polysaccharide markers for treating a site within a patent |
US8498693B2 (en) | 1999-02-02 | 2013-07-30 | Senorx, Inc. | Intracorporeal marker and marker delivery device |
US20090030309A1 (en) | 2007-07-26 | 2009-01-29 | Senorx, Inc. | Deployment of polysaccharide markers |
US8361082B2 (en) | 1999-02-02 | 2013-01-29 | Senorx, Inc. | Marker delivery device with releasable plug |
US6862470B2 (en) | 1999-02-02 | 2005-03-01 | Senorx, Inc. | Cavity-filling biopsy site markers |
US7983734B2 (en) | 2003-05-23 | 2011-07-19 | Senorx, Inc. | Fibrous marker and intracorporeal delivery thereof |
US6419692B1 (en) | 1999-02-03 | 2002-07-16 | Scimed Life Systems, Inc. | Surface protection method for stents and balloon catheters for drug delivery |
US6361557B1 (en) | 1999-02-05 | 2002-03-26 | Medtronic Ave, Inc. | Staplebutton radiopaque marker |
NL1011903C2 (nl) * | 1999-02-05 | 2000-08-08 | Surgical Innovations Vof | Verwijderbare stent. |
WO2000048530A1 (en) * | 1999-02-16 | 2000-08-24 | Talison Research, Inc. | Multilayer and multifunction vascular graft |
US6368658B1 (en) * | 1999-04-19 | 2002-04-09 | Scimed Life Systems, Inc. | Coating medical devices using air suspension |
US6464723B1 (en) | 1999-04-22 | 2002-10-15 | Advanced Cardiovascular Systems, Inc. | Radiopaque stents |
US6620170B1 (en) * | 1999-04-26 | 2003-09-16 | C. R. Bard, Inc. | Devices and methods for treating ischemia by creating a fibrin plug |
US6582715B1 (en) | 1999-04-27 | 2003-06-24 | Agion Technologies, Inc. | Antimicrobial orthopedic implants |
US6156373A (en) | 1999-05-03 | 2000-12-05 | Scimed Life Systems, Inc. | Medical device coating methods and devices |
US6290673B1 (en) * | 1999-05-20 | 2001-09-18 | Conor Medsystems, Inc. | Expandable medical device delivery system and method |
JP2003500174A (ja) | 1999-05-27 | 2003-01-07 | フアルマシア・コーポレーシヨン | スーパーオキシド・ジスムターゼ模倣体で修飾された生体材料 |
AU5168200A (en) * | 1999-05-28 | 2000-12-18 | Minimed, Inc. | Medication device with polymeric surface coating protecting against protein adhesion |
US7387639B2 (en) * | 1999-06-04 | 2008-06-17 | Advanced Stent Technologies, Inc. | Short sleeve stent delivery catheter and methods |
US6575991B1 (en) | 1999-06-17 | 2003-06-10 | Inrad, Inc. | Apparatus for the percutaneous marking of a lesion |
US6258121B1 (en) | 1999-07-02 | 2001-07-10 | Scimed Life Systems, Inc. | Stent coating |
US6503556B2 (en) | 2000-12-28 | 2003-01-07 | Advanced Cardiovascular Systems, Inc. | Methods of forming a coating for a prosthesis |
US20070032853A1 (en) * | 2002-03-27 | 2007-02-08 | Hossainy Syed F | 40-O-(2-hydroxy)ethyl-rapamycin coated stent |
US6790228B2 (en) | 1999-12-23 | 2004-09-14 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
US6759054B2 (en) | 1999-09-03 | 2004-07-06 | Advanced Cardiovascular Systems, Inc. | Ethylene vinyl alcohol composition and coating |
US6713119B2 (en) | 1999-09-03 | 2004-03-30 | Advanced Cardiovascular Systems, Inc. | Biocompatible coating for a prosthesis and a method of forming the same |
US6503954B1 (en) | 2000-03-31 | 2003-01-07 | Advanced Cardiovascular Systems, Inc. | Biocompatible carrier containing actinomycin D and a method of forming the same |
US6749626B1 (en) | 2000-03-31 | 2004-06-15 | Advanced Cardiovascular Systems, Inc. | Actinomycin D for the treatment of vascular disease |
US20040029952A1 (en) * | 1999-09-03 | 2004-02-12 | Yung-Ming Chen | Ethylene vinyl alcohol composition and coating |
US7682647B2 (en) * | 1999-09-03 | 2010-03-23 | Advanced Cardiovascular Systems, Inc. | Thermal treatment of a drug eluting implantable medical device |
US7807211B2 (en) * | 1999-09-03 | 2010-10-05 | Advanced Cardiovascular Systems, Inc. | Thermal treatment of an implantable medical device |
US6585757B1 (en) | 1999-09-15 | 2003-07-01 | Advanced Cardiovascular Systems, Inc. | Endovascular stent with radiopaque spine |
US6689156B1 (en) * | 1999-09-23 | 2004-02-10 | Advanced Stent Technologies, Inc. | Stent range transducers and methods of use |
US6334868B1 (en) | 1999-10-08 | 2002-01-01 | Advanced Cardiovascular Systems, Inc. | Stent cover |
US6387123B1 (en) * | 1999-10-13 | 2002-05-14 | Advanced Cardiovascular Systems, Inc. | Stent with radiopaque core |
US6663606B1 (en) * | 1999-10-28 | 2003-12-16 | Scimed Life Systems, Inc. | Biocompatible medical devices |
US8808272B2 (en) * | 1999-10-28 | 2014-08-19 | Boston Scientific Scimed, Inc. | Biocompatible medical devices |
US6638259B1 (en) * | 1999-10-28 | 2003-10-28 | Scimed Life Systems, Inc. | Biocompatible medical devices |
US6733513B2 (en) | 1999-11-04 | 2004-05-11 | Advanced Bioprosthetic Surfaces, Ltd. | Balloon catheter having metal balloon and method of making same |
EP1229901B1 (en) * | 1999-11-17 | 2009-03-18 | Boston Scientific Limited | Microfabricated devices for the delivery of molecules into a carrier fluid |
US7195641B2 (en) | 1999-11-19 | 2007-03-27 | Advanced Bio Prosthetic Surfaces, Ltd. | Valvular prostheses having metal or pseudometallic construction and methods of manufacture |
US6936066B2 (en) * | 1999-11-19 | 2005-08-30 | Advanced Bio Prosthetic Surfaces, Ltd. | Complaint implantable medical devices and methods of making same |
US6379383B1 (en) | 1999-11-19 | 2002-04-30 | Advanced Bio Prosthetic Surfaces, Ltd. | Endoluminal device exhibiting improved endothelialization and method of manufacture thereof |
US7300457B2 (en) | 1999-11-19 | 2007-11-27 | Advanced Bio Prosthetic Surfaces, Ltd. | Self-supporting metallic implantable grafts, compliant implantable medical devices and methods of making same |
US10172730B2 (en) * | 1999-11-19 | 2019-01-08 | Vactronix Scientific, Llc | Stents with metallic covers and methods of making same |
US8458879B2 (en) * | 2001-07-03 | 2013-06-11 | Advanced Bio Prosthetic Surfaces, Ltd., A Wholly Owned Subsidiary Of Palmaz Scientific, Inc. | Method of fabricating an implantable medical device |
US7736687B2 (en) | 2006-01-31 | 2010-06-15 | Advance Bio Prosthetic Surfaces, Ltd. | Methods of making medical devices |
US7235092B2 (en) * | 1999-11-19 | 2007-06-26 | Advanced Bio Prosthetic Surfaces, Ltd. | Guidewires and thin film catheter-sheaths and method of making same |
US6849085B2 (en) | 1999-11-19 | 2005-02-01 | Advanced Bio Prosthetic Surfaces, Ltd. | Self-supporting laminated films, structural materials and medical devices manufactured therefrom and method of making same |
US6537310B1 (en) | 1999-11-19 | 2003-03-25 | Advanced Bio Prosthetic Surfaces, Ltd. | Endoluminal implantable devices and method of making same |
US6602287B1 (en) | 1999-12-08 | 2003-08-05 | Advanced Cardiovascular Systems, Inc. | Stent with anti-thrombogenic coating |
ATE323470T1 (de) * | 1999-12-10 | 2006-05-15 | Massachusetts Inst Technology | Mikrochip-arzneistoffverabreichungssysteme und herstellungsverfahren |
US6702849B1 (en) * | 1999-12-13 | 2004-03-09 | Advanced Cardiovascular Systems, Inc. | Method of processing open-celled microcellular polymeric foams with controlled porosity for use as vascular grafts and stent covers |
US6338739B1 (en) | 1999-12-22 | 2002-01-15 | Ethicon, Inc. | Biodegradable stent |
US7169187B2 (en) * | 1999-12-22 | 2007-01-30 | Ethicon, Inc. | Biodegradable stent |
US6494908B1 (en) | 1999-12-22 | 2002-12-17 | Ethicon, Inc. | Removable stent for body lumens |
US6981987B2 (en) | 1999-12-22 | 2006-01-03 | Ethicon, Inc. | Removable stent for body lumens |
US6908624B2 (en) * | 1999-12-23 | 2005-06-21 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
US20050238686A1 (en) * | 1999-12-23 | 2005-10-27 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
AU2599501A (en) * | 1999-12-29 | 2001-07-09 | Advanced Cardiovascular Systems Inc. | Device and active component for inhibiting formation of thrombus-inflammatory cell matrix |
US6491617B1 (en) * | 1999-12-30 | 2002-12-10 | St. Jude Medical, Inc. | Medical devices that resist restenosis |
JP2005503178A (ja) * | 2000-01-25 | 2005-02-03 | ボストン サイエンティフィック リミテッド | 蒸着による医療器具の製造 |
US20050267560A1 (en) * | 2000-02-03 | 2005-12-01 | Cook Incorporated | Implantable bioabsorbable valve support frame |
SE0000363A0 (sv) * | 2000-02-04 | 2001-08-05 | Zoucas Kirurgkonsult Ab | Belagd medicinsk anordning |
ATE499988T1 (de) * | 2000-03-02 | 2011-03-15 | Microchips Inc | Mikromechanische geräte und verfahren zur speicherung und zur selektiven exposition von chemikalien |
EP1132058A1 (en) | 2000-03-06 | 2001-09-12 | Advanced Laser Applications Holding S.A. | Intravascular prothesis |
US7220276B1 (en) * | 2000-03-06 | 2007-05-22 | Surmodics, Inc. | Endovascular graft coatings |
US7592017B2 (en) | 2000-03-10 | 2009-09-22 | Mast Biosurgery Ag | Resorbable thin membranes |
US6379382B1 (en) | 2000-03-13 | 2002-04-30 | Jun Yang | Stent having cover with drug delivery capability |
US6613082B2 (en) | 2000-03-13 | 2003-09-02 | Jun Yang | Stent having cover with drug delivery capability |
US9522217B2 (en) | 2000-03-15 | 2016-12-20 | Orbusneich Medical, Inc. | Medical device with coating for capturing genetically-altered cells and methods for using same |
US8088060B2 (en) | 2000-03-15 | 2012-01-03 | Orbusneich Medical, Inc. | Progenitor endothelial cell capturing with a drug eluting implantable medical device |
US6695865B2 (en) | 2000-03-20 | 2004-02-24 | Advanced Bio Prosthetic Surfaces, Ltd. | Embolic protection device |
US6818247B1 (en) | 2000-03-31 | 2004-11-16 | Advanced Cardiovascular Systems, Inc. | Ethylene vinyl alcohol-dimethyl acetamide composition and a method of coating a stent |
WO2001078626A1 (en) * | 2000-04-13 | 2001-10-25 | Sts Biopolymers, Inc. | Targeted therapeutic agent release devices and methods of making and using the same |
US7875283B2 (en) | 2000-04-13 | 2011-01-25 | Advanced Cardiovascular Systems, Inc. | Biodegradable polymers for use with implantable medical devices |
US8109994B2 (en) | 2003-01-10 | 2012-02-07 | Abbott Cardiovascular Systems, Inc. | Biodegradable drug delivery material for stent |
US6527801B1 (en) | 2000-04-13 | 2003-03-04 | Advanced Cardiovascular Systems, Inc. | Biodegradable drug delivery material for stent |
US6514284B1 (en) * | 2000-04-20 | 2003-02-04 | Advanced Cardiovascular Systems, Inc. | Stent having inner flow channels |
US6451050B1 (en) * | 2000-04-28 | 2002-09-17 | Cardiovasc, Inc. | Stent graft and method |
US20040243097A1 (en) * | 2000-05-12 | 2004-12-02 | Robert Falotico | Antiproliferative drug and delivery device |
US8236048B2 (en) * | 2000-05-12 | 2012-08-07 | Cordis Corporation | Drug/drug delivery systems for the prevention and treatment of vascular disease |
US8845713B2 (en) | 2000-05-12 | 2014-09-30 | Advanced Bio Prosthetic Surfaces, Ltd., A Wholly Owned Subsidiary Of Palmaz Scientific, Inc. | Self-supporting laminated films, structural materials and medical devices manufactured therefrom and methods of making same |
US20050002986A1 (en) * | 2000-05-12 | 2005-01-06 | Robert Falotico | Drug/drug delivery systems for the prevention and treatment of vascular disease |
US6776796B2 (en) | 2000-05-12 | 2004-08-17 | Cordis Corportation | Antiinflammatory drug and delivery device |
JP2004500975A (ja) * | 2000-05-16 | 2004-01-15 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | 複数のノズルスプレー操作を用いた高処理量の粒子生成装置及び粒子生成方法 |
US8252044B1 (en) * | 2000-11-17 | 2012-08-28 | Advanced Bio Prosthestic Surfaces, Ltd. | Device for in vivo delivery of bioactive agents and method of manufacture thereof |
KR100360364B1 (ko) * | 2000-05-22 | 2002-11-13 | 주식회사 정성메디칼 | 관상동맥 설치용 금속 스텐트 |
US20040211362A1 (en) * | 2000-05-31 | 2004-10-28 | Daniel Castro | System for coating a stent |
US6395326B1 (en) * | 2000-05-31 | 2002-05-28 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for depositing a coating onto a surface of a prosthesis |
US7682648B1 (en) | 2000-05-31 | 2010-03-23 | Advanced Cardiovascular Systems, Inc. | Methods for forming polymeric coatings on stents |
JP2003534870A (ja) * | 2000-06-05 | 2003-11-25 | シメッド ライフ システムズ インコーポレイテッド | 増大された被膜保持容量を有する血管内ステント |
US6652579B1 (en) | 2000-06-22 | 2003-11-25 | Advanced Cardiovascular Systems, Inc. | Radiopaque stent |
US7029826B2 (en) * | 2000-06-23 | 2006-04-18 | Honeywell International Inc. | Method to restore hydrophobicity in dielectric films and materials |
US20030018380A1 (en) † | 2000-07-07 | 2003-01-23 | Craig Charles H. | Platinum enhanced alloy and intravascular or implantable medical devices manufactured therefrom |
US20030077200A1 (en) * | 2000-07-07 | 2003-04-24 | Craig Charles H. | Enhanced radiopaque alloy stent |
US6506408B1 (en) * | 2000-07-13 | 2003-01-14 | Scimed Life Systems, Inc. | Implantable or insertable therapeutic agent delivery device |
US20040158317A1 (en) * | 2000-07-18 | 2004-08-12 | Pharmasonics, Inc. | Coated stent with ultrasound therapy |
US6799637B2 (en) | 2000-10-20 | 2004-10-05 | Schlumberger Technology Corporation | Expandable tubing and method |
US6451373B1 (en) | 2000-08-04 | 2002-09-17 | Advanced Cardiovascular Systems, Inc. | Method of forming a therapeutic coating onto a surface of an implantable prosthesis |
MXPA03001406A (es) | 2000-08-15 | 2004-05-04 | Surmodics Inc | Matriz de incorporacion de medicamento. |
ES2257436T3 (es) | 2000-08-23 | 2006-08-01 | Thoratec Corporation | Implantes vasculadores revestidos y procedimientos de uso. |
US20020072792A1 (en) * | 2000-09-22 | 2002-06-13 | Robert Burgermeister | Stent with optimal strength and radiopacity characteristics |
WO2002026162A2 (en) * | 2000-09-26 | 2002-04-04 | Advanced Cardiovascular Systems, Inc. | A method of loading a substance onto an implantable device |
US7033374B2 (en) * | 2000-09-26 | 2006-04-25 | Microvention, Inc. | Microcoil vaso-occlusive device with multi-axis secondary configuration |
US6695833B1 (en) * | 2000-09-27 | 2004-02-24 | Nellix, Inc. | Vascular stent-graft apparatus and forming method |
US6953560B1 (en) | 2000-09-28 | 2005-10-11 | Advanced Cardiovascular Systems, Inc. | Barriers for polymer-coated implantable medical devices and methods for making the same |
US6716444B1 (en) | 2000-09-28 | 2004-04-06 | Advanced Cardiovascular Systems, Inc. | Barriers for polymer-coated implantable medical devices and methods for making the same |
CA2424029C (en) | 2000-09-29 | 2008-01-29 | Cordis Corporation | Coated medical devices |
US7261735B2 (en) * | 2001-05-07 | 2007-08-28 | Cordis Corporation | Local drug delivery devices and methods for maintaining the drug coatings thereon |
US20020051730A1 (en) * | 2000-09-29 | 2002-05-02 | Stanko Bodnar | Coated medical devices and sterilization thereof |
US20040106988A1 (en) * | 2000-09-29 | 2004-06-03 | Summers David P. | Resorbable prosthesis for medical treatment |
US20020111590A1 (en) * | 2000-09-29 | 2002-08-15 | Davila Luis A. | Medical devices, drug coatings and methods for maintaining the drug coatings thereon |
US6746773B2 (en) | 2000-09-29 | 2004-06-08 | Ethicon, Inc. | Coatings for medical devices |
EP1339312B1 (en) * | 2000-10-10 | 2006-01-04 | Microchips, Inc. | Microchip reservoir devices using wireless transmission of power and data |
US6764507B2 (en) | 2000-10-16 | 2004-07-20 | Conor Medsystems, Inc. | Expandable medical device with improved spatial distribution |
DE20122506U1 (de) * | 2000-10-16 | 2005-12-08 | Conor Medsystems, Inc., Menlo Park | Ausdehnbare medizinische Vorrichtung zur Abgabe eines nützlichen Agens |
US6918927B2 (en) * | 2000-10-31 | 2005-07-19 | Cook Incorporated | Coated implantable medical device |
US6833153B1 (en) | 2000-10-31 | 2004-12-21 | Advanced Cardiovascular Systems, Inc. | Hemocompatible coatings on hydrophobic porous polymers |
US7807210B1 (en) * | 2000-10-31 | 2010-10-05 | Advanced Cardiovascular Systems, Inc. | Hemocompatible polymers on hydrophobic porous polymers |
US6534693B2 (en) * | 2000-11-06 | 2003-03-18 | Afmedica, Inc. | Surgically implanted devices having reduced scar tissue formation |
WO2002038080A2 (en) * | 2000-11-07 | 2002-05-16 | Advanced Bio Prosthetic Surfaces, Ltd. | Endoluminal stent, self-fupporting endoluminal graft and methods of making same |
US10398830B2 (en) * | 2000-11-17 | 2019-09-03 | Vactronix Scientific, Llc | Device for in vivo delivery of bioactive agents and method of manufacture thereof |
EP1919388B1 (en) | 2000-11-20 | 2012-12-26 | Senorx, Inc. | Tissue site markers for in vivo imaging |
US6517888B1 (en) | 2000-11-28 | 2003-02-11 | Scimed Life Systems, Inc. | Method for manufacturing a medical device having a coated portion by laser ablation |
WO2002055136A2 (en) * | 2000-12-01 | 2002-07-18 | Nephros Therapeutics Inc | Intrasvascular drug delivery device and use therefor |
WO2002047581A1 (en) * | 2000-12-15 | 2002-06-20 | Badari Narayan Nagarada Gadde | Stent with drug-delivery system |
US7244272B2 (en) | 2000-12-19 | 2007-07-17 | Nicast Ltd. | Vascular prosthesis and method for production thereof |
US20040030377A1 (en) * | 2001-10-19 | 2004-02-12 | Alexander Dubson | Medicated polymer-coated stent assembly |
US20070031607A1 (en) * | 2000-12-19 | 2007-02-08 | Alexander Dubson | Method and apparatus for coating medical implants |
WO2002074189A2 (en) * | 2001-03-20 | 2002-09-26 | Nicast Ltd. | Electrospinning nonwoven materials with rotating electrode |
US20020084178A1 (en) * | 2000-12-19 | 2002-07-04 | Nicast Corporation Ltd. | Method and apparatus for manufacturing polymer fiber shells via electrospinning |
US20020082678A1 (en) * | 2000-12-22 | 2002-06-27 | Motasim Sirhan | Intravascular delivery of mizoribine |
US6939375B2 (en) | 2000-12-22 | 2005-09-06 | Avantac Vascular Corporation | Apparatus and methods for controlled substance delivery from implanted prostheses |
US7077859B2 (en) * | 2000-12-22 | 2006-07-18 | Avantec Vascular Corporation | Apparatus and methods for variably controlled substance delivery from implanted prostheses |
US6471980B2 (en) | 2000-12-22 | 2002-10-29 | Avantec Vascular Corporation | Intravascular delivery of mycophenolic acid |
US20030050692A1 (en) * | 2000-12-22 | 2003-03-13 | Avantec Vascular Corporation | Delivery of therapeutic capable agents |
US20030033007A1 (en) * | 2000-12-22 | 2003-02-13 | Avantec Vascular Corporation | Methods and devices for delivery of therapeutic capable agents with variable release profile |
US7083642B2 (en) * | 2000-12-22 | 2006-08-01 | Avantec Vascular Corporation | Delivery of therapeutic capable agents |
US20050125054A1 (en) * | 2000-12-22 | 2005-06-09 | Avantec Vascular Corporation | Devices delivering therapeutic agents and methods regarding the same |
US7018405B2 (en) | 2000-12-22 | 2006-03-28 | Avantec Vascular Corporation | Intravascular delivery of methylprednisolone |
US20050203612A1 (en) * | 2000-12-22 | 2005-09-15 | Avantec Vascular Corporation | Devices delivering therapeutic agents and methods regarding the same |
US6824559B2 (en) | 2000-12-22 | 2004-11-30 | Advanced Cardiovascular Systems, Inc. | Ethylene-carboxyl copolymers as drug delivery matrices |
US20020082679A1 (en) * | 2000-12-22 | 2002-06-27 | Avantec Vascular Corporation | Delivery or therapeutic capable agents |
US6663662B2 (en) | 2000-12-28 | 2003-12-16 | Advanced Cardiovascular Systems, Inc. | Diffusion barrier layer for implantable devices |
US7504125B1 (en) * | 2001-04-27 | 2009-03-17 | Advanced Cardiovascular Systems, Inc. | System and method for coating implantable devices |
US6540776B2 (en) | 2000-12-28 | 2003-04-01 | Advanced Cardiovascular Systems, Inc. | Sheath for a prosthesis and methods of forming the same |
US6641607B1 (en) | 2000-12-29 | 2003-11-04 | Advanced Cardiovascular Systems, Inc. | Double tube stent |
US6635082B1 (en) | 2000-12-29 | 2003-10-21 | Advanced Cardiovascular Systems Inc. | Radiopaque stent |
GB0100761D0 (en) | 2001-01-11 | 2001-02-21 | Biocompatibles Ltd | Drug delivery from stents |
NO335594B1 (no) | 2001-01-16 | 2015-01-12 | Halliburton Energy Serv Inc | Ekspanderbare anordninger og fremgangsmåte for disse |
WO2002078748A2 (en) * | 2001-01-24 | 2002-10-10 | Becton Dickinson And Company | Lubricious coating for medical device |
US6752829B2 (en) * | 2001-01-30 | 2004-06-22 | Scimed Life Systems, Inc. | Stent with channel(s) for containing and delivering a biologically active material and method for manufacturing the same |
US20050182483A1 (en) * | 2004-02-11 | 2005-08-18 | Cook Incorporated | Percutaneously placed prosthesis with thromboresistant valve portion |
US8038708B2 (en) * | 2001-02-05 | 2011-10-18 | Cook Medical Technologies Llc | Implantable device with remodelable material and covering material |
US20040204756A1 (en) * | 2004-02-11 | 2004-10-14 | Diaz Stephen Hunter | Absorbent article with improved liquid acquisition capacity |
US20040073294A1 (en) | 2002-09-20 | 2004-04-15 | Conor Medsystems, Inc. | Method and apparatus for loading a beneficial agent into an expandable medical device |
US20040220660A1 (en) * | 2001-02-05 | 2004-11-04 | Shanley John F. | Bioresorbable stent with beneficial agent reservoirs |
DE10107675B4 (de) * | 2001-02-19 | 2004-11-25 | Implantcast Gmbh | Endoprothese und Verfahren zu ihrer Herstellung |
US6800055B2 (en) | 2001-02-21 | 2004-10-05 | Cordis Corporation | Low attenuating radioactive seeds |
GB0104383D0 (en) * | 2001-02-22 | 2001-04-11 | Psimedica Ltd | Cancer Treatment |
US7026052B2 (en) * | 2001-02-26 | 2006-04-11 | Dielectric Systems, Inc. | Porous low k(<2.0) thin film derived from homo-transport-polymerization |
EP1363695B1 (en) * | 2001-03-01 | 2009-12-23 | David A. Watson | Ingrowth preventing indwelling catheter assembly |
KR200234594Y1 (ko) * | 2001-03-07 | 2001-09-26 | 유태우 | 수지용 지압구 |
US6669621B2 (en) | 2001-03-14 | 2003-12-30 | Cordis Corporation | Method and assembly for containing radioactive materials |
US6497646B1 (en) | 2001-03-14 | 2002-12-24 | Cordis Corporation | Intravascular radiotherapy source ribbon having variable radiopacity |
AU2002252372A1 (en) * | 2001-03-16 | 2002-10-03 | Sts Biopolymers, Inc. | Stent with medicated multi-layer hydrid polymer coating |
US7771468B2 (en) * | 2001-03-16 | 2010-08-10 | Angiotech Biocoatings Corp. | Medicated stent having multi-layer polymer coating |
DE10115740A1 (de) | 2001-03-26 | 2002-10-02 | Ulrich Speck | Zubereitung für die Restenoseprophylaxe |
EP1372531A2 (en) * | 2001-03-30 | 2004-01-02 | Terumo Kabushiki Kaisha | Stent cover and stent |
US6780424B2 (en) | 2001-03-30 | 2004-08-24 | Charles David Claude | Controlled morphologies in polymer drug for release of drugs from polymer films |
SK287686B6 (sk) * | 2001-04-10 | 2011-06-06 | Ciba Specialty Chemicals Holding Inc. | Izolačná kompozícia na strednonapäťové a vysokonapäťové káble a spôsob jej výroby |
US6764505B1 (en) | 2001-04-12 | 2004-07-20 | Advanced Cardiovascular Systems, Inc. | Variable surface area stent |
WO2002085253A1 (en) * | 2001-04-20 | 2002-10-31 | The Board Of Trustees Of The Leland Stanford Junior University | Drug delivery platform and methods for the inhibition of neointima formation |
US7048939B2 (en) * | 2001-04-20 | 2006-05-23 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for the inhibition of neointima formation |
US7056339B2 (en) * | 2001-04-20 | 2006-06-06 | The Board Of Trustees Of The Leland Stanford Junior University | Drug delivery platform |
US6712845B2 (en) * | 2001-04-24 | 2004-03-30 | Advanced Cardiovascular Systems, Inc. | Coating for a stent and a method of forming the same |
US6913762B2 (en) * | 2001-04-25 | 2005-07-05 | Mayo Foundation For Medical Education And Research | Stent having non-woven framework containing cells |
US20020161376A1 (en) * | 2001-04-27 | 2002-10-31 | Barry James J. | Method and system for delivery of coated implants |
US6887857B2 (en) * | 2001-04-27 | 2005-05-03 | Scimed Life Systems, Inc. | Microparticle protection of therapeutic agents |
US7041046B2 (en) | 2001-05-07 | 2006-05-09 | Xoft, Inc. | Combination ionizing radiation and immunomodulator delivery devices and methods for inhibiting hyperplasia |
US8182527B2 (en) * | 2001-05-07 | 2012-05-22 | Cordis Corporation | Heparin barrier coating for controlled drug release |
US6537195B2 (en) | 2001-05-07 | 2003-03-25 | Xoft, Microtube, Inc. | Combination x-ray radiation and drug delivery devices and methods for inhibiting hyperplasia |
US6656506B1 (en) * | 2001-05-09 | 2003-12-02 | Advanced Cardiovascular Systems, Inc. | Microparticle coated medical device |
WO2002090540A1 (en) * | 2001-05-10 | 2002-11-14 | The Salk Institute For Biological Studies | Ethylene insensitive plants |
US7666462B2 (en) * | 2001-05-11 | 2010-02-23 | Exogenesis Corporation | Method of controlling a drug release rate |
US20100036502A1 (en) | 2008-08-07 | 2010-02-11 | Exogenesis Corporation | Medical device for bone implant and method for producing such device |
WO2002093988A1 (en) * | 2001-05-11 | 2002-11-21 | Epion Corporation | Method and system for improving the effectiveness of medical devices by adhering drugs to the surface thereof |
US6685745B2 (en) * | 2001-05-15 | 2004-02-03 | Scimed Life Systems, Inc. | Delivering an agent to a patient's body |
US7247338B2 (en) * | 2001-05-16 | 2007-07-24 | Regents Of The University Of Minnesota | Coating medical devices |
US7651695B2 (en) * | 2001-05-18 | 2010-01-26 | Advanced Cardiovascular Systems, Inc. | Medicated stents for the treatment of vascular disease |
US8617231B2 (en) | 2001-05-18 | 2013-12-31 | Boston Scientific Scimed, Inc. | Dual guidewire exchange catheter system |
US6981964B2 (en) | 2001-05-22 | 2006-01-03 | Boston Scientific Scimed, Inc. | Draining bodily fluids with a stent |
US7862495B2 (en) * | 2001-05-31 | 2011-01-04 | Advanced Cardiovascular Systems, Inc. | Radiation or drug delivery source with activity gradient to minimize edge effects |
US6743462B1 (en) | 2001-05-31 | 2004-06-01 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for coating implantable devices |
US7128755B2 (en) * | 2001-06-01 | 2006-10-31 | Texas Stent Technologies, Inc. | Expandable biodegradable polymeric stents for combined mechanical support and pharmacological or radiation therapy |
GB0113697D0 (en) * | 2001-06-06 | 2001-07-25 | Smith & Nephew | Fixation devices for tissue repair |
US20020188314A1 (en) * | 2001-06-07 | 2002-12-12 | Microvena Corporation | Radiopaque distal embolic protection device |
US7510571B2 (en) * | 2001-06-11 | 2009-03-31 | Boston Scientific, Scimed, Inc. | Pleated composite ePTFE/textile hybrid covering |
US7201940B1 (en) * | 2001-06-12 | 2007-04-10 | Advanced Cardiovascular Systems, Inc. | Method and apparatus for thermal spray processing of medical devices |
EP2316394B1 (en) | 2001-06-12 | 2016-11-23 | The Johns Hopkins University | Reservoir device for intraocular drug delivery |
US20030044514A1 (en) * | 2001-06-13 | 2003-03-06 | Richard Robert E. | Using supercritical fluids to infuse therapeutic on a medical device |
US7175873B1 (en) | 2001-06-27 | 2007-02-13 | Advanced Cardiovascular Systems, Inc. | Rate limiting barriers for implantable devices and methods for fabrication thereof |
US8741378B1 (en) | 2001-06-27 | 2014-06-03 | Advanced Cardiovascular Systems, Inc. | Methods of coating an implantable device |
US7247313B2 (en) * | 2001-06-27 | 2007-07-24 | Advanced Cardiovascular Systems, Inc. | Polyacrylates coatings for implantable medical devices |
WO2003002243A2 (en) | 2001-06-27 | 2003-01-09 | Remon Medical Technologies Ltd. | Method and device for electrochemical formation of therapeutic species in vivo |
US6695920B1 (en) * | 2001-06-27 | 2004-02-24 | Advanced Cardiovascular Systems, Inc. | Mandrel for supporting a stent and a method of using the mandrel to coat a stent |
US6656216B1 (en) | 2001-06-29 | 2003-12-02 | Advanced Cardiovascular Systems, Inc. | Composite stent with regioselective material |
EP1273314A1 (en) | 2001-07-06 | 2003-01-08 | Terumo Kabushiki Kaisha | Stent |
US6704600B2 (en) | 2001-07-13 | 2004-03-09 | Cardiac Pacemakers, Inc. | Device programmer with enclosed imaging capability |
US7246321B2 (en) * | 2001-07-13 | 2007-07-17 | Anoto Ab | Editing data |
US7286877B2 (en) * | 2001-07-13 | 2007-10-23 | Cardiac Pacemakers, Inc. | Device programmer with enclosed imaging capability |
US7572288B2 (en) * | 2001-07-20 | 2009-08-11 | Microvention, Inc. | Aneurysm treatment device and method of use |
US8715312B2 (en) * | 2001-07-20 | 2014-05-06 | Microvention, Inc. | Aneurysm treatment device and method of use |
US8252040B2 (en) | 2001-07-20 | 2012-08-28 | Microvention, Inc. | Aneurysm treatment device and method of use |
DE60120955T3 (de) | 2001-07-20 | 2015-06-25 | Cid S.P.A. | Stent |
AU2002322719A1 (en) * | 2001-07-26 | 2003-02-17 | Avantec Vascular Corporation | Delivery of therapeutic capable agents |
AU2002320456A1 (en) * | 2001-07-26 | 2003-02-17 | Alveolus Inc. | Removable stent and method of using the same |
SE523216C2 (sv) * | 2001-07-27 | 2004-04-06 | Zoucas Kirurgkonsult Ab | Heparinstent |
US7682669B1 (en) | 2001-07-30 | 2010-03-23 | Advanced Cardiovascular Systems, Inc. | Methods for covalently immobilizing anti-thrombogenic material into a coating on a medical device |
US20040249443A1 (en) * | 2001-08-20 | 2004-12-09 | Shanley John F. | Expandable medical device for treating cardiac arrhythmias |
US7842083B2 (en) * | 2001-08-20 | 2010-11-30 | Innovational Holdings, Llc. | Expandable medical device with improved spatial distribution |
US7056338B2 (en) | 2003-03-28 | 2006-06-06 | Conor Medsystems, Inc. | Therapeutic agent delivery device with controlled therapeutic agent release rates |
DE10142637B4 (de) * | 2001-08-31 | 2009-07-09 | Disetronic Licensing Ag | Transkutanes Implantat mit Oberflächenstruktur sowie Verfahren zur Herstellung eines solchen Implantats |
US8303651B1 (en) | 2001-09-07 | 2012-11-06 | Advanced Cardiovascular Systems, Inc. | Polymeric coating for reducing the rate of release of a therapeutic substance from a stent |
US20080145402A1 (en) * | 2001-09-10 | 2008-06-19 | Abbott Cardiovascular Systems Inc. | Medical Devices Containing Rapamycin Analogs |
US20050129728A1 (en) * | 2001-09-11 | 2005-06-16 | Martinod Serge R. | Sustained release pharmaceutical composition |
US7285304B1 (en) * | 2003-06-25 | 2007-10-23 | Advanced Cardiovascular Systems, Inc. | Fluid treatment of a polymeric coating on an implantable medical device |
US7989018B2 (en) * | 2001-09-17 | 2011-08-02 | Advanced Cardiovascular Systems, Inc. | Fluid treatment of a polymeric coating on an implantable medical device |
US6863683B2 (en) | 2001-09-19 | 2005-03-08 | Abbott Laboratoris Vascular Entities Limited | Cold-molding process for loading a stent onto a stent delivery system |
US6790223B2 (en) | 2001-09-21 | 2004-09-14 | Scimed Life Systems, Inc. | Delivering a uretheral stent |
EP1429689A4 (en) * | 2001-09-24 | 2006-03-08 | Medtronic Ave Inc | DEVICE AND METHODS FOR RATIONAL MEDICINAL THERAPY |
DE60238422D1 (de) | 2001-09-24 | 2011-01-05 | Boston Scient Ltd | Optimierte dosierung bei paclitaxelhaltigen stents |
US6827737B2 (en) * | 2001-09-25 | 2004-12-07 | Scimed Life Systems, Inc. | EPTFE covering for endovascular prostheses and method of manufacture |
US7195640B2 (en) * | 2001-09-25 | 2007-03-27 | Cordis Corporation | Coated medical devices for the treatment of vulnerable plaque |
US20030059520A1 (en) | 2001-09-27 | 2003-03-27 | Yung-Ming Chen | Apparatus for regulating temperature of a composition and a method of coating implantable devices |
US6753071B1 (en) * | 2001-09-27 | 2004-06-22 | Advanced Cardiovascular Systems, Inc. | Rate-reducing membrane for release of an agent |
US7223282B1 (en) * | 2001-09-27 | 2007-05-29 | Advanced Cardiovascular Systems, Inc. | Remote activation of an implantable device |
US20030065377A1 (en) * | 2001-09-28 | 2003-04-03 | Davila Luis A. | Coated medical devices |
US20030065345A1 (en) * | 2001-09-28 | 2003-04-03 | Kevin Weadock | Anastomosis devices and methods for treating anastomotic sites |
US7108701B2 (en) * | 2001-09-28 | 2006-09-19 | Ethicon, Inc. | Drug releasing anastomosis devices and methods for treating anastomotic sites |
US20030065382A1 (en) * | 2001-10-02 | 2003-04-03 | Fischell Robert E. | Means and method for the treatment of coronary artery obstructions |
DE10150995A1 (de) | 2001-10-08 | 2003-04-10 | Biotronik Mess & Therapieg | Implantat mit proliferationshemmender Substanz |
US7033389B2 (en) * | 2001-10-16 | 2006-04-25 | Scimed Life Systems, Inc. | Tubular prosthesis for external agent delivery |
US20030077310A1 (en) * | 2001-10-22 | 2003-04-24 | Chandrashekhar Pathak | Stent coatings containing HMG-CoA reductase inhibitors |
US8740973B2 (en) * | 2001-10-26 | 2014-06-03 | Icon Medical Corp. | Polymer biodegradable medical device |
GB0125925D0 (en) * | 2001-10-29 | 2001-12-19 | Univ Glasgow | Mitral valve prosthesis |
US6936040B2 (en) * | 2001-10-29 | 2005-08-30 | Medtronic, Inc. | Method and apparatus for endovenous pacing lead |
US7179283B2 (en) * | 2001-11-02 | 2007-02-20 | Scimed Life Systems, Inc. | Vapor deposition process for producing a stent-graft and a stent-graft produced therefrom |
US7682387B2 (en) * | 2002-04-24 | 2010-03-23 | Biosensors International Group, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
US6939376B2 (en) * | 2001-11-05 | 2005-09-06 | Sun Biomedical, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
US7585516B2 (en) | 2001-11-12 | 2009-09-08 | Advanced Cardiovascular Systems, Inc. | Coatings for drug delivery devices |
EP1310242A1 (en) * | 2001-11-13 | 2003-05-14 | SORIN BIOMEDICA CARDIO S.p.A. | Carrier and kit for endoluminal delivery of active principles |
US6663880B1 (en) | 2001-11-30 | 2003-12-16 | Advanced Cardiovascular Systems, Inc. | Permeabilizing reagents to increase drug delivery and a method of local delivery |
US7175874B1 (en) | 2001-11-30 | 2007-02-13 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for coating implantable devices |
AU2002359576A1 (en) | 2001-12-03 | 2003-06-17 | Ekos Corporation | Catheter with multiple ultrasound radiating members |
US6945994B2 (en) * | 2001-12-05 | 2005-09-20 | Boston Scientific Scimed, Inc. | Combined balloon-expanding and self-expanding stent |
US6709514B1 (en) | 2001-12-28 | 2004-03-23 | Advanced Cardiovascular Systems, Inc. | Rotary coating apparatus for coating implantable medical devices |
US20030216758A1 (en) * | 2001-12-28 | 2003-11-20 | Angiotech Pharmaceuticals, Inc. | Coated surgical patches |
US7473273B2 (en) * | 2002-01-22 | 2009-01-06 | Medtronic Vascular, Inc. | Stent assembly with therapeutic agent exterior banding |
US7445629B2 (en) * | 2002-01-31 | 2008-11-04 | Boston Scientific Scimed, Inc. | Medical device for delivering biologically active material |
US7326245B2 (en) * | 2002-01-31 | 2008-02-05 | Boston Scientific Scimed, Inc. | Medical device for delivering biologically active material |
US7291165B2 (en) * | 2002-01-31 | 2007-11-06 | Boston Scientific Scimed, Inc. | Medical device for delivering biologically active material |
IL162734A0 (en) | 2002-02-01 | 2005-11-20 | Ariad Gene Therapeutics Inc | Phosphorus-containing compounds & uses thereof |
US7993390B2 (en) * | 2002-02-08 | 2011-08-09 | Boston Scientific Scimed, Inc. | Implantable or insertable medical device resistant to microbial growth and biofilm formation |
US6887270B2 (en) * | 2002-02-08 | 2005-05-03 | Boston Scientific Scimed, Inc. | Implantable or insertable medical device resistant to microbial growth and biofilm formation |
US7613491B2 (en) | 2002-05-22 | 2009-11-03 | Dexcom, Inc. | Silicone based membranes for use in implantable glucose sensors |
US10022078B2 (en) | 2004-07-13 | 2018-07-17 | Dexcom, Inc. | Analyte sensor |
US8364229B2 (en) | 2003-07-25 | 2013-01-29 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
US7008397B2 (en) | 2002-02-13 | 2006-03-07 | Percardia, Inc. | Cardiac implant and methods |
JP3993773B2 (ja) * | 2002-02-20 | 2007-10-17 | 株式会社日立製作所 | ストレージサブシステム、記憶制御装置及びデータコピー方法 |
GB0204381D0 (en) * | 2002-02-26 | 2002-04-10 | Mcminn Derek J W | Knee prosthesis |
US8328877B2 (en) * | 2002-03-19 | 2012-12-11 | Boston Scientific Scimed, Inc. | Stent retention element and related methods |
US7919075B1 (en) | 2002-03-20 | 2011-04-05 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical devices |
US7022334B1 (en) | 2002-03-20 | 2006-04-04 | Advanced Cardiovascular Systems, Inc. | Therapeutic composition and a method of coating implantable medical devices |
US20030204248A1 (en) * | 2002-03-25 | 2003-10-30 | Murphy Kieran P. | Device viewable under an imaging beam |
US9375203B2 (en) | 2002-03-25 | 2016-06-28 | Kieran Murphy Llc | Biopsy needle |
US7927368B2 (en) | 2002-03-25 | 2011-04-19 | Kieran Murphy Llc | Device viewable under an imaging beam |
US20030181810A1 (en) | 2002-03-25 | 2003-09-25 | Murphy Kieran P. | Kit for image guided surgical procedures |
US7288111B1 (en) * | 2002-03-26 | 2007-10-30 | Thoratec Corporation | Flexible stent and method of making the same |
KR100496354B1 (ko) * | 2002-03-27 | 2005-06-20 | 서울산업대학교 산학협력단 | 생분해성 고분자 지지체층을 포함하는 하이브리드인공혈관 및 그의 제조 방법 |
US8226629B1 (en) | 2002-04-01 | 2012-07-24 | Ekos Corporation | Ultrasonic catheter power control |
US20070227907A1 (en) * | 2006-04-04 | 2007-10-04 | Rajiv Shah | Methods and materials for controlling the electrochemistry of analyte sensors |
US7813780B2 (en) | 2005-12-13 | 2010-10-12 | Medtronic Minimed, Inc. | Biosensors and methods for making and using them |
US9492111B2 (en) * | 2002-04-22 | 2016-11-15 | Medtronic Minimed, Inc. | Methods and materials for stabilizing analyte sensors |
US20040024450A1 (en) * | 2002-04-24 | 2004-02-05 | Sun Biomedical, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
AU2003231229A1 (en) * | 2002-04-30 | 2003-11-17 | Cook Biotech Incorporated | Sling for supporting tissue |
US7122048B2 (en) * | 2002-05-03 | 2006-10-17 | Scimed Life Systems, Inc. | Hypotube endoluminal device |
US8313760B2 (en) * | 2002-05-24 | 2012-11-20 | Angiotech International Ag | Compositions and methods for coating medical implants |
PT1509256E (pt) * | 2002-05-24 | 2009-10-15 | Angiotech Int Ag | Composições e métodos de revestimento de implantes médicos |
US20030229392A1 (en) * | 2002-06-03 | 2003-12-11 | Wong Samuel J. | Drug eluted vascular graft |
US20040234703A1 (en) * | 2002-06-04 | 2004-11-25 | Frautschi Jack R. | Method of forming a polymer layer on a metal surface |
US6835387B2 (en) * | 2002-06-11 | 2004-12-28 | Scimed Life Systems, Inc. | Sustained release of superoxide dismutase mimics from implantable or insertable medical devices |
US7097850B2 (en) * | 2002-06-18 | 2006-08-29 | Surmodics, Inc. | Bioactive agent release coating and controlled humidity method |
US20030232087A1 (en) * | 2002-06-18 | 2003-12-18 | Lawin Laurie R. | Bioactive agent release coating with aromatic poly(meth)acrylates |
US7011842B1 (en) | 2002-06-21 | 2006-03-14 | Advanced Cardiovascular Systems, Inc. | Polycationic peptide coatings and methods of making the same |
US7033602B1 (en) * | 2002-06-21 | 2006-04-25 | Advanced Cardiovascular Systems, Inc. | Polycationic peptide coatings and methods of coating implantable medical devices |
US7217426B1 (en) | 2002-06-21 | 2007-05-15 | Advanced Cardiovascular Systems, Inc. | Coatings containing polycationic peptides for cardiovascular therapy |
US7070798B1 (en) | 2002-06-21 | 2006-07-04 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical devices incorporating chemically-bound polymers and oligomers of L-arginine |
US7794743B2 (en) * | 2002-06-21 | 2010-09-14 | Advanced Cardiovascular Systems, Inc. | Polycationic peptide coatings and methods of making the same |
US7056523B1 (en) | 2002-06-21 | 2006-06-06 | Advanced Cardiovascular Systems, Inc. | Implantable medical devices incorporating chemically conjugated polymers and oligomers of L-arginine |
US8506617B1 (en) | 2002-06-21 | 2013-08-13 | Advanced Cardiovascular Systems, Inc. | Micronized peptide coated stent |
US7396539B1 (en) * | 2002-06-21 | 2008-07-08 | Advanced Cardiovascular Systems, Inc. | Stent coatings with engineered drug release rate |
US6994867B1 (en) | 2002-06-21 | 2006-02-07 | Advanced Cardiovascular Systems, Inc. | Biocompatible carrier containing L-arginine |
US20040002755A1 (en) * | 2002-06-28 | 2004-01-01 | Fischell David R. | Method and apparatus for treating vulnerable coronary plaques using drug-eluting stents |
EP1521603B1 (en) | 2002-07-12 | 2011-01-19 | Cook Incorporated | Coated medical device |
US7294329B1 (en) * | 2002-07-18 | 2007-11-13 | Advanced Cardiovascular Systems, Inc. | Poly(vinyl acetal) coatings for implantable medical devices |
US7622146B2 (en) * | 2002-07-18 | 2009-11-24 | Advanced Cardiovascular Systems, Inc. | Rate limiting barriers for implantable devices and methods for fabrication thereof |
US20050065596A1 (en) * | 2002-07-24 | 2005-03-24 | Xufan Tseng | Stents capable of controllably releasing histone deacetylase inhibitors |
WO2004010900A1 (en) * | 2002-07-25 | 2004-02-05 | Avantec Vascular Corporation | Devices delivering therapeutic agents and methods regarding the same |
WO2004011051A1 (en) * | 2002-07-29 | 2004-02-05 | Potencia Medical Ag | Durable implant |
US20040034275A1 (en) | 2002-07-29 | 2004-02-19 | Peter Forsell | Multi-material incontinence treatment constriction device |
CN101919722A (zh) * | 2002-07-31 | 2010-12-22 | 微温森公司 | 三部件同轴的血管闭塞装置 |
US8016881B2 (en) | 2002-07-31 | 2011-09-13 | Icon Interventional Systems, Inc. | Sutures and surgical staples for anastamoses, wound closures, and surgical closures |
US8048444B2 (en) * | 2002-07-31 | 2011-11-01 | Mast Biosurgery Ag | Apparatus and method for preventing adhesions between an implant and surrounding tissues |
US20050171572A1 (en) | 2002-07-31 | 2005-08-04 | Microvention, Inc. | Multi-layer coaxial vaso-occlusive device |
EP1545389B1 (en) * | 2002-07-31 | 2020-04-22 | Mast Biosurgery AG | Apparatus for preventing adhesions between an implant and surrounding tissues |
US20040034338A1 (en) * | 2002-08-07 | 2004-02-19 | Ams Research Corporation | Drug delivery devices and methods |
US7363074B1 (en) * | 2002-08-20 | 2008-04-22 | Advanced Cardiovascular Systems, Inc. | Coatings comprising self-assembled molecular structures and a method of delivering a drug using the same |
US7438925B2 (en) * | 2002-08-26 | 2008-10-21 | Biovention Holdings Ltd. | Drug eluting coatings for medical implants |
US7732535B2 (en) * | 2002-09-05 | 2010-06-08 | Advanced Cardiovascular Systems, Inc. | Coating for controlled release of drugs from implantable medical devices |
US20040054104A1 (en) * | 2002-09-05 | 2004-03-18 | Pacetti Stephen D. | Coatings for drug delivery devices comprising modified poly(ethylene-co-vinyl alcohol) |
CA2497640C (en) * | 2002-09-06 | 2012-02-07 | Abbott Laboratories | Medical device having hydration inhibitor |
US7704520B1 (en) | 2002-09-10 | 2010-04-27 | Mast Biosurgery Ag | Methods of promoting enhanced healing of tissues after cardiac surgery |
US7201935B1 (en) | 2002-09-17 | 2007-04-10 | Advanced Cardiovascular Systems, Inc. | Plasma-generated coatings for medical devices and methods for fabricating thereof |
US7438722B1 (en) | 2002-09-20 | 2008-10-21 | Advanced Cardiovascular Systems, Inc. | Method for treatment of restenosis |
DE10244847A1 (de) * | 2002-09-20 | 2004-04-01 | Ulrich Prof. Dr. Speck | Medizinische Vorrichtung zur Arzneimittelabgabe |
AU2003276920A1 (en) * | 2002-09-20 | 2004-04-08 | Innovational Holdings, Llc | Expandable medical device with openings for delivery of multiple beneficial agents |
US7758636B2 (en) * | 2002-09-20 | 2010-07-20 | Innovational Holdings Llc | Expandable medical device with openings for delivery of multiple beneficial agents |
US20040059409A1 (en) * | 2002-09-24 | 2004-03-25 | Stenzel Eric B. | Method of applying coatings to a medical device |
US8679517B2 (en) | 2002-09-26 | 2014-03-25 | Palmaz Scientific, Inc. | Implantable materials having engineered surfaces made by vacuum deposition and method of making same |
US7232573B1 (en) * | 2002-09-26 | 2007-06-19 | Advanced Cardiovascular Systems, Inc. | Stent coatings containing self-assembled monolayers |
MXPA05003238A (es) * | 2002-09-26 | 2005-09-12 | Endovascular Devices Inc | Aparato y metodo para administrar mitomicina a traves de un dispositivo medico implantable biocompatible de elucion. |
WO2004028340A2 (en) | 2002-09-26 | 2004-04-08 | Advanced Bio Prosthetic Surfaces, Ltd. | High strength vacuum deposited nitionol alloy films, medical thin film graft materials and method of making same |
US8202530B2 (en) * | 2002-09-27 | 2012-06-19 | Advanced Cardiovascular Systems, Inc. | Biocompatible coatings for stents |
US7404979B1 (en) * | 2002-09-30 | 2008-07-29 | Advanced Cardiovascular Systems Inc. | Spin coating apparatus and a method for coating implantable devices |
US8337937B2 (en) * | 2002-09-30 | 2012-12-25 | Abbott Cardiovascular Systems Inc. | Stent spin coating method |
US7087263B2 (en) * | 2002-10-09 | 2006-08-08 | Advanced Cardiovascular Systems, Inc. | Rare limiting barriers for implantable medical devices |
US6921371B2 (en) | 2002-10-14 | 2005-07-26 | Ekos Corporation | Ultrasound radiating members for catheter |
WO2004034874A2 (en) * | 2002-10-15 | 2004-04-29 | Norbert Thompson | Parylene-coated silicone t-tubes and method of use thereof |
US20050272989A1 (en) * | 2004-06-04 | 2005-12-08 | Medtronic Minimed, Inc. | Analyte sensors and methods for making and using them |
US20040074785A1 (en) * | 2002-10-18 | 2004-04-22 | Holker James D. | Analyte sensors and methods for making them |
US9237865B2 (en) * | 2002-10-18 | 2016-01-19 | Medtronic Minimed, Inc. | Analyte sensors and methods for making and using them |
KR100511030B1 (ko) * | 2002-10-21 | 2005-08-31 | 한국과학기술연구원 | 혈액적합성 의료용 금속 재료 및 이의 제조 방법 |
US6733536B1 (en) * | 2002-10-22 | 2004-05-11 | Scimed Life Systems | Male urethral stent device |
EP1569762B1 (en) * | 2002-10-22 | 2007-10-03 | Medtronic Vascular, Inc. | Stent with intermittent coating |
US20040093056A1 (en) * | 2002-10-26 | 2004-05-13 | Johnson Lianw M. | Medical appliance delivery apparatus and method of use |
US7527644B2 (en) * | 2002-11-05 | 2009-05-05 | Alveolus Inc. | Stent with geometry determinated functionality and method of making the same |
US7959671B2 (en) * | 2002-11-05 | 2011-06-14 | Merit Medical Systems, Inc. | Differential covering and coating methods |
US7637942B2 (en) * | 2002-11-05 | 2009-12-29 | Merit Medical Systems, Inc. | Coated stent with geometry determinated functionality and method of making the same |
US7875068B2 (en) | 2002-11-05 | 2011-01-25 | Merit Medical Systems, Inc. | Removable biliary stent |
WO2004043507A1 (en) * | 2002-11-07 | 2004-05-27 | Carbon Medical Technologies, Inc. | Biocompatible medical device coatings |
US8221495B2 (en) | 2002-11-07 | 2012-07-17 | Abbott Laboratories | Integration of therapeutic agent into a bioerodible medical device |
US7208190B2 (en) * | 2002-11-07 | 2007-04-24 | Abbott Laboratories | Method of loading beneficial agent to a prosthesis by fluid-jet application |
US8524148B2 (en) * | 2002-11-07 | 2013-09-03 | Abbott Laboratories | Method of integrating therapeutic agent into a bioerodible medical device |
US20040142014A1 (en) * | 2002-11-08 | 2004-07-22 | Conor Medsystems, Inc. | Method and apparatus for reducing tissue damage after ischemic injury |
EP1560613A1 (en) * | 2002-11-08 | 2005-08-10 | Conor Medsystems, Inc. | Method and apparatus for reducing tissue damage after ischemic injury |
CA2505576A1 (en) * | 2002-11-08 | 2004-05-27 | Conor Medsystems, Inc. | Expandable medical device and method for treating chronic total occlusions with local delivery of an angiogenic factor |
US7022372B1 (en) | 2002-11-12 | 2006-04-04 | Advanced Cardiovascular Systems, Inc. | Compositions for coating implantable medical devices |
US8034361B2 (en) * | 2002-11-12 | 2011-10-11 | Advanced Cardiovascular Systems, Inc. | Stent coatings incorporating nanoparticles |
US7169178B1 (en) | 2002-11-12 | 2007-01-30 | Advanced Cardiovascular Systems, Inc. | Stent with drug coating |
US6896965B1 (en) * | 2002-11-12 | 2005-05-24 | Advanced Cardiovascular Systems, Inc. | Rate limiting barriers for implantable devices |
DK2336318T3 (da) | 2002-11-13 | 2013-07-15 | Genzyme Corp | Antisense-modulering af apolipoprotein b-ekspression |
US9770349B2 (en) * | 2002-11-13 | 2017-09-26 | University Of Virginia Patent Foundation | Nanoporous stents with enhanced cellular adhesion and reduced neointimal formation |
EP1569695B1 (en) | 2002-11-13 | 2013-05-15 | Genzyme Corporation | Antisense modulation of apolipoprotein b expression |
US20060121080A1 (en) * | 2002-11-13 | 2006-06-08 | Lye Whye K | Medical devices having nanoporous layers and methods for making the same |
US7285287B2 (en) * | 2002-11-14 | 2007-10-23 | Synecor, Llc | Carbon dioxide-assisted methods of providing biocompatible intraluminal prostheses |
US20040098106A1 (en) * | 2002-11-14 | 2004-05-20 | Williams Michael S. | Intraluminal prostheses and carbon dioxide-assisted methods of impregnating same with pharmacological agents |
US20060036158A1 (en) | 2003-11-17 | 2006-02-16 | Inrad, Inc. | Self-contained, self-piercing, side-expelling marking apparatus |
US6982004B1 (en) | 2002-11-26 | 2006-01-03 | Advanced Cardiovascular Systems, Inc. | Electrostatic loading of drugs on implantable medical devices |
US20040158289A1 (en) * | 2002-11-30 | 2004-08-12 | Girouard Steven D. | Method and apparatus for cell and electrical therapy of living tissue |
US7627373B2 (en) * | 2002-11-30 | 2009-12-01 | Cardiac Pacemakers, Inc. | Method and apparatus for cell and electrical therapy of living tissue |
US6918869B2 (en) * | 2002-12-02 | 2005-07-19 | Scimed Life Systems | System for administering a combination of therapies to a body lumen |
US7491234B2 (en) * | 2002-12-03 | 2009-02-17 | Boston Scientific Scimed, Inc. | Medical devices for delivery of therapeutic agents |
US7211150B1 (en) * | 2002-12-09 | 2007-05-01 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for coating and drying multiple stents |
US7758880B2 (en) | 2002-12-11 | 2010-07-20 | Advanced Cardiovascular Systems, Inc. | Biocompatible polyacrylate compositions for medical applications |
US7776926B1 (en) | 2002-12-11 | 2010-08-17 | Advanced Cardiovascular Systems, Inc. | Biocompatible coating for implantable medical devices |
US7074276B1 (en) * | 2002-12-12 | 2006-07-11 | Advanced Cardiovascular Systems, Inc. | Clamp mandrel fixture and a method of using the same to minimize coating defects |
US20060002968A1 (en) * | 2004-06-30 | 2006-01-05 | Gordon Stewart | Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders |
US7094256B1 (en) | 2002-12-16 | 2006-08-22 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical device containing polycationic peptides |
US7758881B2 (en) | 2004-06-30 | 2010-07-20 | Advanced Cardiovascular Systems, Inc. | Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device |
US8435550B2 (en) * | 2002-12-16 | 2013-05-07 | Abbot Cardiovascular Systems Inc. | Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device |
US7338557B1 (en) * | 2002-12-17 | 2008-03-04 | Advanced Cardiovascular Systems, Inc. | Nozzle for use in coating a stent |
US20040236415A1 (en) * | 2003-01-02 | 2004-11-25 | Richard Thomas | Medical devices having drug releasing polymer reservoirs |
WO2004068555A2 (en) * | 2003-01-25 | 2004-08-12 | Honeywell International Inc | Repair and restoration of damaged dielectric materials and films |
US7087115B1 (en) | 2003-02-13 | 2006-08-08 | Advanced Cardiovascular Systems, Inc. | Nozzle and method for use in coating a stent |
DE60334676D1 (de) | 2003-02-21 | 2010-12-09 | Sorin Biomedica Cardio Srl | Verfahren zur Herstellung eines Stents und entsprechender Stent |
US6926919B1 (en) | 2003-02-26 | 2005-08-09 | Advanced Cardiovascular Systems, Inc. | Method for fabricating a coating for a medical device |
US7255891B1 (en) | 2003-02-26 | 2007-08-14 | Advanced Cardiovascular Systems, Inc. | Method for coating implantable medical devices |
US8715771B2 (en) * | 2003-02-26 | 2014-05-06 | Abbott Cardiovascular Systems Inc. | Coated stent and method of making the same |
US20090093875A1 (en) * | 2007-05-01 | 2009-04-09 | Abbott Laboratories | Drug eluting stents with prolonged local elution profiles with high local concentrations and low systemic concentrations |
US7563483B2 (en) * | 2003-02-26 | 2009-07-21 | Advanced Cardiovascular Systems Inc. | Methods for fabricating a coating for implantable medical devices |
US7063884B2 (en) * | 2003-02-26 | 2006-06-20 | Advanced Cardiovascular Systems, Inc. | Stent coating |
US20060083767A1 (en) * | 2003-02-27 | 2006-04-20 | Kai Deusch | Surgical prosthesis having biodegradable and nonbiodegradable regions |
US7288609B1 (en) | 2003-03-04 | 2007-10-30 | Advanced Cardiovascular Systems, Inc. | Coatings for drug delivery devices based on poly (orthoesters) |
US8281737B2 (en) * | 2003-03-10 | 2012-10-09 | Boston Scientific Scimed, Inc. | Coated medical device and method for manufacturing the same |
US6932930B2 (en) * | 2003-03-10 | 2005-08-23 | Synecor, Llc | Intraluminal prostheses having polymeric material with selectively modified crystallinity and methods of making same |
US8512290B2 (en) * | 2003-03-20 | 2013-08-20 | Boston Scientific Scimed, Inc. | Devices and methods for delivering therapeutic or diagnostic agents |
US7481798B2 (en) * | 2003-03-20 | 2009-01-27 | Boston Scientific Scimed, Inc. | Devices and methods for delivering therapeutic or diagnostic agents |
US20050049672A1 (en) * | 2003-03-24 | 2005-03-03 | Murphy Kieran P. | Stent delivery system and method using a balloon for a self-expandable stent |
US7182745B2 (en) * | 2003-03-25 | 2007-02-27 | Boston Scientific Scimed, Inc. | Retaining stent |
US20040202692A1 (en) * | 2003-03-28 | 2004-10-14 | Conor Medsystems, Inc. | Implantable medical device and method for in situ selective modulation of agent delivery |
AU2004226350A1 (en) * | 2003-03-28 | 2004-10-14 | Kosan Biosciences, Inc. | Devices, methods, and compositions to prevent restenosis |
US20050010170A1 (en) * | 2004-02-11 | 2005-01-13 | Shanley John F | Implantable medical device with beneficial agent concentration gradient |
EP1610823B1 (en) * | 2003-03-28 | 2011-09-28 | Innovational Holdings, LLC | Implantable medical device with continuous agent concentration gradient |
US7637934B2 (en) * | 2003-03-31 | 2009-12-29 | Merit Medical Systems, Inc. | Medical appliance optical delivery and deployment apparatus and method |
US20040243224A1 (en) * | 2003-04-03 | 2004-12-02 | Medtronic Vascular, Inc. | Methods and compositions for inhibiting narrowing in mammalian vascular pathways |
US7306580B2 (en) * | 2003-04-16 | 2007-12-11 | Cook Incorporated | Medical device with therapeutic agents |
US20040215313A1 (en) * | 2003-04-22 | 2004-10-28 | Peiwen Cheng | Stent with sandwich type coating |
US20040236290A1 (en) * | 2003-04-23 | 2004-11-25 | Zimmermann Stephan A. | Minimally invasive vascular apparatus modified to minimize scarring at introduction site |
US20040247671A1 (en) * | 2003-04-25 | 2004-12-09 | Prescott James H. | Solid drug formulation and device for storage and controlled delivery thereof |
US20040220534A1 (en) * | 2003-04-29 | 2004-11-04 | Martens Paul W. | Medical device with antimicrobial layer |
US8791171B2 (en) | 2003-05-01 | 2014-07-29 | Abbott Cardiovascular Systems Inc. | Biodegradable coatings for implantable medical devices |
US7563454B1 (en) * | 2003-05-01 | 2009-07-21 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical devices |
DE602004028638D1 (de) * | 2003-05-02 | 2010-09-23 | Surmodics Inc | System zur kontrollierten Freisetzung eines bioaktiven Wirkstoffs im hinteren Bereich des Auges |
US8246974B2 (en) * | 2003-05-02 | 2012-08-21 | Surmodics, Inc. | Medical devices and methods for producing the same |
DE602004024053D1 (de) | 2003-05-07 | 2009-12-24 | Advanced Bio Prothestic Surfac | Metallische implantierbare prothesen und herstellungsverfahren dafür |
US7279174B2 (en) * | 2003-05-08 | 2007-10-09 | Advanced Cardiovascular Systems, Inc. | Stent coatings comprising hydrophilic additives |
US7651529B2 (en) * | 2003-05-09 | 2010-01-26 | Boston Scientific Scimed, Inc. | Stricture retractor |
US7323209B1 (en) * | 2003-05-15 | 2008-01-29 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for coating stents |
US20050112273A1 (en) * | 2003-05-19 | 2005-05-26 | Stenzel Eric B. | Method of improving the quality and performance of a coating on a coated medical device using a solvent to reflow the coating |
US7877133B2 (en) | 2003-05-23 | 2011-01-25 | Senorx, Inc. | Marker or filler forming fluid |
US20060217797A1 (en) * | 2003-05-23 | 2006-09-28 | Wong Samuel J | Asymmetric drug eluting hemodialysis graft |
DE10324365A1 (de) * | 2003-05-27 | 2005-01-05 | Forschungszentrum Jülich GmbH | Vorrichtung mit einer Räumlichkeit zur Aufnahme von hyperpolarisiertem Edelgas |
US7169179B2 (en) * | 2003-06-05 | 2007-01-30 | Conor Medsystems, Inc. | Drug delivery device and method for bi-directional drug delivery |
US7247986B2 (en) * | 2003-06-10 | 2007-07-24 | Samsung Sdi. Co., Ltd. | Organic electro luminescent display and method for fabricating the same |
US20050118344A1 (en) | 2003-12-01 | 2005-06-02 | Pacetti Stephen D. | Temperature controlled crimping |
US7645504B1 (en) | 2003-06-26 | 2010-01-12 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical devices comprising hydrophobic and hydrophilic polymers |
US7341630B1 (en) * | 2003-06-26 | 2008-03-11 | Advanced Cardiovascular Systems, Inc. | Stent coating system |
US9039755B2 (en) | 2003-06-27 | 2015-05-26 | Medinol Ltd. | Helical hybrid stent |
US9155639B2 (en) | 2009-04-22 | 2015-10-13 | Medinol Ltd. | Helical hybrid stent |
US7467720B2 (en) * | 2003-07-07 | 2008-12-23 | Wisconsin Label Corporation | Product display hanger strip |
US7875285B1 (en) | 2003-07-15 | 2011-01-25 | Advanced Cardiovascular Systems, Inc. | Medicated coatings for implantable medical devices having controlled rate of release |
US20050021127A1 (en) * | 2003-07-21 | 2005-01-27 | Kawula Paul John | Porous glass fused onto stent for drug retention |
US9763609B2 (en) | 2003-07-25 | 2017-09-19 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
US7651596B2 (en) | 2005-04-08 | 2010-01-26 | Dexcom, Inc. | Cellulosic-based interference domain for an analyte sensor |
US7169404B2 (en) * | 2003-07-30 | 2007-01-30 | Advanced Cardiovasular Systems, Inc. | Biologically absorbable coatings for implantable devices and methods for fabricating the same |
US7056591B1 (en) * | 2003-07-30 | 2006-06-06 | Advanced Cardiovascular Systems, Inc. | Hydrophobic biologically absorbable coatings for drug delivery devices and methods for fabricating the same |
US7645474B1 (en) | 2003-07-31 | 2010-01-12 | Advanced Cardiovascular Systems, Inc. | Method and system of purifying polymers for use with implantable medical devices |
US7431959B1 (en) | 2003-07-31 | 2008-10-07 | Advanced Cardiovascular Systems Inc. | Method and system for irradiation of a drug eluting implantable medical device |
US7785512B1 (en) | 2003-07-31 | 2010-08-31 | Advanced Cardiovascular Systems, Inc. | Method and system of controlled temperature mixing and molding of polymers with active agents for implantable medical devices |
US7591801B2 (en) | 2004-02-26 | 2009-09-22 | Dexcom, Inc. | Integrated delivery device for continuous glucose sensor |
GB0318353D0 (en) * | 2003-08-05 | 2003-09-10 | Phoqus Pharmaceuticals Ltd | Coating of surgical devices |
US7185524B2 (en) * | 2003-08-14 | 2007-03-06 | Tyco Healthcare Group Lp | Grindless surgical needle manufacture |
US20050043786A1 (en) * | 2003-08-18 | 2005-02-24 | Medtronic Ave, Inc. | Methods and apparatus for treatment of aneurysmal tissue |
US8298280B2 (en) | 2003-08-21 | 2012-10-30 | Boston Scientific Scimed, Inc. | Stent with protruding branch portion for bifurcated vessels |
US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
US20100266663A1 (en) * | 2003-09-10 | 2010-10-21 | Calhoun Christopher J | Tissue-treating implantable compositions |
US7488343B2 (en) * | 2003-09-16 | 2009-02-10 | Boston Scientific Scimed, Inc. | Medical devices |
US20050060020A1 (en) * | 2003-09-17 | 2005-03-17 | Scimed Life Systems, Inc. | Covered stent with biologically active material |
US7785653B2 (en) * | 2003-09-22 | 2010-08-31 | Innovational Holdings Llc | Method and apparatus for loading a beneficial agent into an expandable medical device |
US8801692B2 (en) * | 2003-09-24 | 2014-08-12 | Medtronic Vascular, Inc. | Gradient coated stent and method of fabrication |
US7441513B1 (en) | 2003-09-26 | 2008-10-28 | Advanced Cardiovascular Systems, Inc. | Plasma-generated coating apparatus for medical devices and a method of coating deposition |
US7318932B2 (en) * | 2003-09-30 | 2008-01-15 | Advanced Cardiovascular Systems, Inc. | Coatings for drug delivery devices comprising hydrolitically stable adducts of poly(ethylene-co-vinyl alcohol) and methods for fabricating the same |
US7198675B2 (en) | 2003-09-30 | 2007-04-03 | Advanced Cardiovascular Systems | Stent mandrel fixture and method for selectively coating surfaces of a stent |
US7704544B2 (en) * | 2003-10-07 | 2010-04-27 | Advanced Cardiovascular Systems, Inc. | System and method for coating a tubular implantable medical device |
US8475666B2 (en) * | 2004-09-15 | 2013-07-02 | Honeywell International Inc. | Method for making toughening agent materials |
US7329413B1 (en) * | 2003-11-06 | 2008-02-12 | Advanced Cardiovascular Systems, Inc. | Coatings for drug delivery devices having gradient of hydration and methods for fabricating thereof |
US20050100577A1 (en) * | 2003-11-10 | 2005-05-12 | Parker Theodore L. | Expandable medical device with beneficial agent matrix formed by a multi solvent system |
US7344557B2 (en) * | 2003-11-12 | 2008-03-18 | Advanced Stent Technologies, Inc. | Catheter balloon systems and methods |
US7261946B2 (en) * | 2003-11-14 | 2007-08-28 | Advanced Cardiovascular Systems, Inc. | Block copolymers of acrylates and methacrylates with fluoroalkenes |
US20050273002A1 (en) | 2004-06-04 | 2005-12-08 | Goosen Ryan L | Multi-mode imaging marker |
US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
US9114198B2 (en) * | 2003-11-19 | 2015-08-25 | Advanced Cardiovascular Systems, Inc. | Biologically beneficial coatings for implantable devices containing fluorinated polymers and methods for fabricating the same |
WO2005051451A2 (en) * | 2003-11-20 | 2005-06-09 | Angiotech International Ag | Electrical devices and anti-scarring agents |
US8192752B2 (en) * | 2003-11-21 | 2012-06-05 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable devices including biologically erodable polyesters and methods for fabricating the same |
US7560492B1 (en) * | 2003-11-25 | 2009-07-14 | Advanced Cardiovascular Systems, Inc. | Polysulfone block copolymers as drug-eluting coating material |
US7807722B2 (en) * | 2003-11-26 | 2010-10-05 | Advanced Cardiovascular Systems, Inc. | Biobeneficial coating compositions and methods of making and using thereof |
US8691258B2 (en) * | 2003-12-12 | 2014-04-08 | Medtronic, Inc. | Anti-infective medical device |
US7220816B2 (en) * | 2003-12-16 | 2007-05-22 | Advanced Cardiovascular Systems, Inc. | Biologically absorbable coatings for implantable devices based on poly(ester amides) and methods for fabricating the same |
US20050131513A1 (en) * | 2003-12-16 | 2005-06-16 | Cook Incorporated | Stent catheter with a permanently affixed conductor |
US20050137677A1 (en) * | 2003-12-17 | 2005-06-23 | Rush Scott L. | Endovascular graft with differentiable porosity along its length |
US20050137679A1 (en) * | 2003-12-17 | 2005-06-23 | Pfizer Inc | Modified stent useful for delivery of drugs along stent strut |
US20050154451A1 (en) * | 2003-12-18 | 2005-07-14 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
US20050149174A1 (en) * | 2003-12-18 | 2005-07-07 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
US20050154455A1 (en) * | 2003-12-18 | 2005-07-14 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
US20050137683A1 (en) * | 2003-12-19 | 2005-06-23 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
US7435788B2 (en) * | 2003-12-19 | 2008-10-14 | Advanced Cardiovascular Systems, Inc. | Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents |
US20050154452A1 (en) * | 2003-12-23 | 2005-07-14 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
US20050152940A1 (en) * | 2003-12-23 | 2005-07-14 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
US20050152942A1 (en) * | 2003-12-23 | 2005-07-14 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
US20050152943A1 (en) * | 2003-12-23 | 2005-07-14 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
US8309112B2 (en) * | 2003-12-24 | 2012-11-13 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical devices comprising hydrophilic substances and methods for fabricating the same |
WO2005065578A2 (en) * | 2004-01-06 | 2005-07-21 | Nicast Ltd. | Vascular prosthesis with anastomotic member |
US20050159809A1 (en) * | 2004-01-21 | 2005-07-21 | Medtronic Vascular, Inc. | Implantable medical devices for treating or preventing restenosis |
US7211108B2 (en) * | 2004-01-23 | 2007-05-01 | Icon Medical Corp. | Vascular grafts with amphiphilic block copolymer coatings |
US20050165452A1 (en) * | 2004-01-28 | 2005-07-28 | Medtronic, Inc. | Antithrombogenic medical device |
US7803178B2 (en) | 2004-01-30 | 2010-09-28 | Trivascular, Inc. | Inflatable porous implants and methods for drug delivery |
US7341569B2 (en) * | 2004-01-30 | 2008-03-11 | Ekos Corporation | Treatment of vascular occlusions using ultrasonic energy and microbubbles |
US7349971B2 (en) * | 2004-02-05 | 2008-03-25 | Scenera Technologies, Llc | System for transmitting data utilizing multiple communication applications simultaneously in response to user request without specifying recipient's communication information |
WO2005079339A2 (en) * | 2004-02-12 | 2005-09-01 | The University Of Akron | Improved stent for use in arteries |
JP2007521928A (ja) * | 2004-02-13 | 2007-08-09 | コナー メドシステムズ, インコーポレイテッド | ワイヤフィラメントを含む埋め込み可能薬剤送出デバイス |
US20050197691A1 (en) * | 2004-02-18 | 2005-09-08 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
US8137397B2 (en) | 2004-02-26 | 2012-03-20 | Boston Scientific Scimed, Inc. | Medical devices |
US8808228B2 (en) | 2004-02-26 | 2014-08-19 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
US7840263B2 (en) * | 2004-02-27 | 2010-11-23 | Cardiac Pacemakers, Inc. | Method and apparatus for device controlled gene expression |
US8685431B2 (en) * | 2004-03-16 | 2014-04-01 | Advanced Cardiovascular Systems, Inc. | Biologically absorbable coatings for implantable devices based on copolymers having ester bonds and methods for fabricating the same |
US8551512B2 (en) | 2004-03-22 | 2013-10-08 | Advanced Cardiovascular Systems, Inc. | Polyethylene glycol/poly(butylene terephthalate) copolymer coated devices including EVEROLIMUS |
US20050208093A1 (en) * | 2004-03-22 | 2005-09-22 | Thierry Glauser | Phosphoryl choline coating compositions |
US20050214339A1 (en) | 2004-03-29 | 2005-09-29 | Yiwen Tang | Biologically degradable compositions for medical applications |
US20050220835A1 (en) * | 2004-03-30 | 2005-10-06 | Jayaraman Ramesh B | Agent eluting bioimplantable devices and polymer systems for their preparation |
US8778014B1 (en) | 2004-03-31 | 2014-07-15 | Advanced Cardiovascular Systems, Inc. | Coatings for preventing balloon damage to polymer coated stents |
US20060083772A1 (en) * | 2004-04-06 | 2006-04-20 | Dewitt David M | Coating compositions for bioactive agents |
WO2005099786A1 (en) * | 2004-04-06 | 2005-10-27 | Surmodics, Inc. | Coating compositions for bioactive agents |
US20050228490A1 (en) * | 2004-04-09 | 2005-10-13 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
US7335264B2 (en) * | 2004-04-22 | 2008-02-26 | Boston Scientific Scimed, Inc. | Differentially coated medical devices, system for differentially coating medical devices, and coating method |
US7553377B1 (en) * | 2004-04-27 | 2009-06-30 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for electrostatic coating of an abluminal stent surface |
US20050265960A1 (en) * | 2004-05-26 | 2005-12-01 | Pacetti Stephen D | Polymers containing poly(ester amides) and agents for use with medical articles and methods of fabricating the same |
US7066935B2 (en) * | 2004-04-30 | 2006-06-27 | Medtronic, Inc. | Ion eluting tuna device |
US7820732B2 (en) * | 2004-04-30 | 2010-10-26 | Advanced Cardiovascular Systems, Inc. | Methods for modulating thermal and mechanical properties of coatings on implantable devices |
US8293890B2 (en) | 2004-04-30 | 2012-10-23 | Advanced Cardiovascular Systems, Inc. | Hyaluronic acid based copolymers |
US7390524B1 (en) | 2004-05-20 | 2008-06-24 | Advanced Cardiovascular Systems, Inc. | Method for electrostatic spraying of an abluminal stent surface |
US20050261762A1 (en) * | 2004-05-21 | 2005-11-24 | Medtronic Vascular, Inc. | Medical devices to prevent or inhibit restenosis |
US9561309B2 (en) * | 2004-05-27 | 2017-02-07 | Advanced Cardiovascular Systems, Inc. | Antifouling heparin coatings |
US20050266042A1 (en) * | 2004-05-27 | 2005-12-01 | Medtronic Vascular, Inc. | Methods and apparatus for treatment of aneurysmal tissue |
US20050266039A1 (en) * | 2004-05-27 | 2005-12-01 | Jan Weber | Coated medical device and method for making the same |
US7764995B2 (en) | 2004-06-07 | 2010-07-27 | Cardiac Pacemakers, Inc. | Method and apparatus to modulate cellular regeneration post myocardial infarct |
JP5054524B2 (ja) | 2004-06-08 | 2012-10-24 | アドバンスド ステント テクノロジーズ, インコーポレイテッド | 分岐管用突出枝部を備えたステント |
EP1604697A1 (en) | 2004-06-09 | 2005-12-14 | J.A.C.C. GmbH | Implantable device |
WO2006002112A1 (en) * | 2004-06-18 | 2006-01-05 | Surmodics, Inc. | Devices, articles, coatings, and methods for controlled active agent release |
US7563780B1 (en) * | 2004-06-18 | 2009-07-21 | Advanced Cardiovascular Systems, Inc. | Heparin prodrugs and drug delivery stents formed therefrom |
US7794490B2 (en) * | 2004-06-22 | 2010-09-14 | Boston Scientific Scimed, Inc. | Implantable medical devices with antimicrobial and biodegradable matrices |
US20050287287A1 (en) * | 2004-06-24 | 2005-12-29 | Parker Theodore L | Methods and systems for loading an implantable medical device with beneficial agent |
US8568469B1 (en) | 2004-06-28 | 2013-10-29 | Advanced Cardiovascular Systems, Inc. | Stent locking element and a method of securing a stent on a delivery system |
US20050287184A1 (en) | 2004-06-29 | 2005-12-29 | Hossainy Syed F A | Drug-delivery stent formulations for restenosis and vulnerable plaque |
US8241554B1 (en) | 2004-06-29 | 2012-08-14 | Advanced Cardiovascular Systems, Inc. | Method of forming a stent pattern on a tube |
US7820936B2 (en) | 2004-07-02 | 2010-10-26 | Boston Scientific Scimed, Inc. | Method and apparatus for controlling and adjusting the intensity profile of a laser beam employed in a laser welder for welding polymeric and metallic components |
US20060009839A1 (en) * | 2004-07-12 | 2006-01-12 | Scimed Life Systems, Inc. | Composite vascular graft including bioactive agent coating and biodegradable sheath |
US8747879B2 (en) | 2006-04-28 | 2014-06-10 | Advanced Cardiovascular Systems, Inc. | Method of fabricating an implantable medical device to reduce chance of late inflammatory response |
US8747878B2 (en) | 2006-04-28 | 2014-06-10 | Advanced Cardiovascular Systems, Inc. | Method of fabricating an implantable medical device by controlling crystalline structure |
US8778256B1 (en) | 2004-09-30 | 2014-07-15 | Advanced Cardiovascular Systems, Inc. | Deformation of a polymer tube in the fabrication of a medical article |
US7731890B2 (en) | 2006-06-15 | 2010-06-08 | Advanced Cardiovascular Systems, Inc. | Methods of fabricating stents with enhanced fracture toughness |
US7971333B2 (en) | 2006-05-30 | 2011-07-05 | Advanced Cardiovascular Systems, Inc. | Manufacturing process for polymetric stents |
US20060025848A1 (en) * | 2004-07-29 | 2006-02-02 | Jan Weber | Medical device having a coating layer with structural elements therein and method of making the same |
US7494665B1 (en) * | 2004-07-30 | 2009-02-24 | Advanced Cardiovascular Systems, Inc. | Polymers containing siloxane monomers |
US8357391B2 (en) | 2004-07-30 | 2013-01-22 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable devices comprising poly (hydroxy-alkanoates) and diacid linkages |
US7311980B1 (en) | 2004-08-02 | 2007-12-25 | Advanced Cardiovascular Systems, Inc. | Polyactive/polylactic acid coatings for an implantable device |
US20060029640A1 (en) * | 2004-08-05 | 2006-02-09 | Gilbert Jeremy L | Medical devices with surface modification for regulating cell growth on or near the surface |
CN101018512B (zh) * | 2004-08-13 | 2011-05-18 | 马斯特生物外科股份公司 | 具有可生物降解区和不可生物降解区的外科手术假体 |
US20080091277A1 (en) * | 2004-08-13 | 2008-04-17 | Kai Deusch | Surgical prosthesis having biodegradable and nonbiodegradable regions |
US9283099B2 (en) | 2004-08-25 | 2016-03-15 | Advanced Cardiovascular Systems, Inc. | Stent-catheter assembly with a releasable connection for stent retention |
US7648727B2 (en) * | 2004-08-26 | 2010-01-19 | Advanced Cardiovascular Systems, Inc. | Methods for manufacturing a coated stent-balloon assembly |
US7244443B2 (en) * | 2004-08-31 | 2007-07-17 | Advanced Cardiovascular Systems, Inc. | Polymers of fluorinated monomers and hydrophilic monomers |
US20060052822A1 (en) * | 2004-08-31 | 2006-03-09 | Mirizzi Michael S | Apparatus and material composition for permanent occlusion of a hollow anatomical structure |
US7507433B2 (en) * | 2004-09-03 | 2009-03-24 | Boston Scientific Scimed, Inc. | Method of coating a medical device using an electrowetting process |
US20060051390A1 (en) * | 2004-09-03 | 2006-03-09 | Schwarz Marlene C | Medical devices having self-forming rate-controlling barrier for drug release |
US7229471B2 (en) | 2004-09-10 | 2007-06-12 | Advanced Cardiovascular Systems, Inc. | Compositions containing fast-leaching plasticizers for improved performance of medical devices |
US7063720B2 (en) * | 2004-09-14 | 2006-06-20 | The Wallace Enterprises, Inc. | Covered stent with controlled therapeutic agent diffusion |
US20060062822A1 (en) * | 2004-09-21 | 2006-03-23 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
US8110211B2 (en) * | 2004-09-22 | 2012-02-07 | Advanced Cardiovascular Systems, Inc. | Medicated coatings for implantable medical devices including polyacrylates |
US7901451B2 (en) * | 2004-09-24 | 2011-03-08 | Biosensors International Group, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
US8043553B1 (en) | 2004-09-30 | 2011-10-25 | Advanced Cardiovascular Systems, Inc. | Controlled deformation of a polymer tube with a restraining surface in fabricating a medical article |
US7875233B2 (en) | 2004-09-30 | 2011-01-25 | Advanced Cardiovascular Systems, Inc. | Method of fabricating a biaxially oriented implantable medical device |
US9011831B2 (en) * | 2004-09-30 | 2015-04-21 | Advanced Cardiovascular Systems, Inc. | Methacrylate copolymers for medical devices |
US8173062B1 (en) | 2004-09-30 | 2012-05-08 | Advanced Cardiovascular Systems, Inc. | Controlled deformation of a polymer tube in fabricating a medical article |
US7347810B2 (en) * | 2004-10-01 | 2008-03-25 | Stamos Thomas A | Device for draining the coronary sinus |
US7166680B2 (en) | 2004-10-06 | 2007-01-23 | Advanced Cardiovascular Systems, Inc. | Blends of poly(ester amide) polymers |
WO2006042114A1 (en) | 2004-10-06 | 2006-04-20 | Cook, Inc. | Emboli capturing device having a coil and method for capturing emboli |
US20060083770A1 (en) * | 2004-10-15 | 2006-04-20 | Specialty Coating Systems, Inc. | Medical devices and methods of preparation and use |
AU2005296053B2 (en) * | 2004-10-18 | 2011-03-10 | Covidien Lp | Compression anastomosis device and method |
US20060083859A1 (en) | 2004-10-20 | 2006-04-20 | Todd Robida | Magnetic levitation system for coating a device, a method of using the system, and device made by the system |
US20060088571A1 (en) * | 2004-10-21 | 2006-04-27 | Medtronic Vascular, Inc. | Biocompatible and hemocompatible polymer compositions |
US8603634B2 (en) | 2004-10-27 | 2013-12-10 | Abbott Cardiovascular Systems Inc. | End-capped poly(ester amide) copolymers |
US20060089485A1 (en) * | 2004-10-27 | 2006-04-27 | Desnoyer Jessica R | End-capped poly(ester amide) copolymers |
US20060093647A1 (en) * | 2004-10-29 | 2006-05-04 | Villafana Manuel A | Multiple layer coating composition |
US7390497B2 (en) * | 2004-10-29 | 2008-06-24 | Advanced Cardiovascular Systems, Inc. | Poly(ester amide) filler blends for modulation of coating properties |
US20060095122A1 (en) * | 2004-10-29 | 2006-05-04 | Advanced Cardiovascular Systems, Inc. | Implantable devices comprising biologically absorbable star polymers and methods for fabricating the same |
US7481835B1 (en) | 2004-10-29 | 2009-01-27 | Advanced Cardiovascular Systems, Inc. | Encapsulated covered stent |
US20060093642A1 (en) * | 2004-11-03 | 2006-05-04 | Ranade Shrirang V | Method of incorporating carbon nanotubes in a medical appliance, a carbon nanotube medical appliance, and a medical appliance coated using carbon nanotube technology |
US7455688B2 (en) * | 2004-11-12 | 2008-11-25 | Con Interventional Systems, Inc. | Ostial stent |
US8419656B2 (en) * | 2004-11-22 | 2013-04-16 | Bard Peripheral Vascular, Inc. | Post decompression marker introducer system |
US7214759B2 (en) * | 2004-11-24 | 2007-05-08 | Advanced Cardiovascular Systems, Inc. | Biologically absorbable coatings for implantable devices based on polyesters and methods for fabricating the same |
US7588642B1 (en) | 2004-11-29 | 2009-09-15 | Advanced Cardiovascular Systems, Inc. | Abluminal stent coating apparatus and method using a brush assembly |
US8609123B2 (en) * | 2004-11-29 | 2013-12-17 | Advanced Cardiovascular Systems, Inc. | Derivatized poly(ester amide) as a biobeneficial coating |
US20060115449A1 (en) * | 2004-11-30 | 2006-06-01 | Advanced Cardiovascular Systems, Inc. | Bioabsorbable, biobeneficial, tyrosine-based polymers for use in drug eluting stent coatings |
US7892592B1 (en) | 2004-11-30 | 2011-02-22 | Advanced Cardiovascular Systems, Inc. | Coating abluminal surfaces of stents and other implantable medical devices |
EP1827551A1 (en) * | 2004-12-06 | 2007-09-05 | SurModics, Inc. | Multifunctional medical articles |
US7943161B2 (en) * | 2004-12-08 | 2011-05-17 | Cook Incorporated | Contrast agent coated medical device |
US20060127443A1 (en) * | 2004-12-09 | 2006-06-15 | Helmus Michael N | Medical devices having vapor deposited nanoporous coatings for controlled therapeutic agent delivery |
US20060129221A1 (en) * | 2004-12-10 | 2006-06-15 | Medtronic, Inc. | Tunneling guide |
US8874204B2 (en) * | 2004-12-20 | 2014-10-28 | Cardiac Pacemakers, Inc. | Implantable medical devices comprising isolated extracellular matrix |
US8060219B2 (en) * | 2004-12-20 | 2011-11-15 | Cardiac Pacemakers, Inc. | Epicardial patch including isolated extracellular matrix with pacing electrodes |
US7981065B2 (en) | 2004-12-20 | 2011-07-19 | Cardiac Pacemakers, Inc. | Lead electrode incorporating extracellular matrix |
US7604818B2 (en) * | 2004-12-22 | 2009-10-20 | Advanced Cardiovascular Systems, Inc. | Polymers of fluorinated monomers and hydrocarbon monomers |
US7419504B2 (en) * | 2004-12-27 | 2008-09-02 | Advanced Cardiovascular Systems, Inc. | Poly(ester amide) block copolymers |
US8007775B2 (en) * | 2004-12-30 | 2011-08-30 | Advanced Cardiovascular Systems, Inc. | Polymers containing poly(hydroxyalkanoates) and agents for use with medical articles and methods of fabricating the same |
US7344601B2 (en) * | 2005-01-05 | 2008-03-18 | Boston Scientific Scimed, Inc. | Integrated cross-wire fixture for coating a device, a method of using the fixture, and a device made using the fixture |
US20070150051A1 (en) * | 2005-01-10 | 2007-06-28 | Duke Fiduciary, Llc | Vascular implants and methods of fabricating the same |
US8287583B2 (en) * | 2005-01-10 | 2012-10-16 | Taheri Laduca Llc | Apparatus and method for deploying an implantable device within the body |
US7202325B2 (en) * | 2005-01-14 | 2007-04-10 | Advanced Cardiovascular Systems, Inc. | Poly(hydroxyalkanoate-co-ester amides) and agents for use with medical articles |
US7488316B2 (en) | 2005-01-25 | 2009-02-10 | Microchips, Inc. | Control of drug release by transient modification of local microenvironments |
CN102525591B (zh) | 2005-01-25 | 2014-12-10 | 泰科医疗集团有限合伙公司 | 用于永久性闭塞中空解剖结构的结构 |
US8057543B2 (en) * | 2005-01-28 | 2011-11-15 | Greatbatch Ltd. | Stent coating for eluting medication |
US20060171980A1 (en) * | 2005-02-01 | 2006-08-03 | Helmus Michael N | Implantable or insertable medical devices having optimal surface energy |
WO2006084191A2 (en) * | 2005-02-04 | 2006-08-10 | The Regents Of The University Of California | Local gene therapy with an eluting stent for vascular injury |
US7161076B2 (en) * | 2005-02-16 | 2007-01-09 | Chia-Chun Hsu | Button structure of saxophone |
US7491225B2 (en) | 2005-02-16 | 2009-02-17 | Boston Scientific Scimed, Inc. | System and method for deploying a drug-eluting external body and tissue scaffold |
CN101573086A (zh) * | 2005-02-17 | 2009-11-04 | 尼卡斯特有限公司 | 可膨胀医疗设备 |
CA3054535A1 (en) * | 2005-02-18 | 2006-08-24 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
US8735394B2 (en) * | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
US20060193891A1 (en) * | 2005-02-25 | 2006-08-31 | Robert Richard | Medical devices and therapeutic delivery devices composed of bioabsorbable polymers produced at room temperature, method of making the devices, and a system for making the devices |
AU2005100176A4 (en) * | 2005-03-01 | 2005-04-07 | Gym Tv Pty Ltd | Garbage bin clip |
US20060200048A1 (en) * | 2005-03-03 | 2006-09-07 | Icon Medical Corp. | Removable sheath for device protection |
US7540995B2 (en) | 2005-03-03 | 2009-06-02 | Icon Medical Corp. | Process for forming an improved metal alloy stent |
WO2006110197A2 (en) * | 2005-03-03 | 2006-10-19 | Icon Medical Corp. | Polymer biodegradable medical device |
US20060201601A1 (en) * | 2005-03-03 | 2006-09-14 | Icon Interventional Systems, Inc. | Flexible markers |
US20060264914A1 (en) * | 2005-03-03 | 2006-11-23 | Icon Medical Corp. | Metal alloys for medical devices |
US8323333B2 (en) * | 2005-03-03 | 2012-12-04 | Icon Medical Corp. | Fragile structure protective coating |
US7488444B2 (en) * | 2005-03-03 | 2009-02-10 | Icon Medical Corp. | Metal alloys for medical devices |
US9107899B2 (en) | 2005-03-03 | 2015-08-18 | Icon Medical Corporation | Metal alloys for medical devices |
US8945169B2 (en) | 2005-03-15 | 2015-02-03 | Cook Medical Technologies Llc | Embolic protection device |
US8221446B2 (en) | 2005-03-15 | 2012-07-17 | Cook Medical Technologies | Embolic protection device |
GB0505724D0 (en) * | 2005-03-19 | 2005-04-27 | Smiths Group Plc | Tracheostomy tubes |
US9381279B2 (en) | 2005-03-24 | 2016-07-05 | Abbott Cardiovascular Systems Inc. | Implantable devices formed on non-fouling methacrylate or acrylate polymers |
US7700659B2 (en) * | 2005-03-24 | 2010-04-20 | Advanced Cardiovascular Systems, Inc. | Implantable devices formed of non-fouling methacrylate or acrylate polymers |
US8744546B2 (en) | 2005-05-05 | 2014-06-03 | Dexcom, Inc. | Cellulosic-based resistance domain for an analyte sensor |
EP1874197A4 (en) * | 2005-04-12 | 2010-02-10 | Ekos Corp | ULTRASONIC SURFACE CATHETER PROMOTING CAVITATION |
US7381048B2 (en) | 2005-04-12 | 2008-06-03 | Advanced Cardiovascular Systems, Inc. | Stents with profiles for gripping a balloon catheter and molds for fabricating stents |
US10357328B2 (en) | 2005-04-20 | 2019-07-23 | Bard Peripheral Vascular, Inc. and Bard Shannon Limited | Marking device with retractable cannula |
US7795467B1 (en) | 2005-04-26 | 2010-09-14 | Advanced Cardiovascular Systems, Inc. | Bioabsorbable, biobeneficial polyurethanes for use in medical devices |
US8778375B2 (en) * | 2005-04-29 | 2014-07-15 | Advanced Cardiovascular Systems, Inc. | Amorphous poly(D,L-lactide) coating |
US20060246210A1 (en) * | 2005-04-29 | 2006-11-02 | Vascular Architects Inc., A Delaware Corporation | Method for making a covered drug-eluting stent |
KR20080008364A (ko) * | 2005-05-05 | 2008-01-23 | 헤모텍 아게 | 관 스텐트의 전면 코팅 |
US20060257355A1 (en) * | 2005-05-10 | 2006-11-16 | Abiomed, Inc. | Impregnated polymer compositions and devices using them |
US7637941B1 (en) | 2005-05-11 | 2009-12-29 | Advanced Cardiovascular Systems, Inc. | Endothelial cell binding coatings for rapid encapsulation of bioerodable stents |
US20060259115A1 (en) * | 2005-05-13 | 2006-11-16 | Case Brian C | Medical device delivery systems that facilitate medical device placement in the presence of ultrasonic waves |
US7772393B2 (en) * | 2005-06-13 | 2010-08-10 | Innovative Surface Technologies, Inc. | Photochemical crosslinkers for polymer coatings and substrate tie-layer |
AU2006259415B2 (en) * | 2005-06-15 | 2012-08-30 | Massachusetts Institute Of Technology | Amine-containing lipids and uses thereof |
US20070009564A1 (en) * | 2005-06-22 | 2007-01-11 | Mcclain James B | Drug/polymer composite materials and methods of making the same |
US7823533B2 (en) * | 2005-06-30 | 2010-11-02 | Advanced Cardiovascular Systems, Inc. | Stent fixture and method for reducing coating defects |
US20070038176A1 (en) * | 2005-07-05 | 2007-02-15 | Jan Weber | Medical devices with machined layers for controlled communications with underlying regions |
US8021676B2 (en) | 2005-07-08 | 2011-09-20 | Advanced Cardiovascular Systems, Inc. | Functionalized chemically inert polymers for coatings |
WO2007011708A2 (en) | 2005-07-15 | 2007-01-25 | Micell Technologies, Inc. | Stent with polymer coating containing amorphous rapamycin |
KR101406415B1 (ko) | 2005-07-15 | 2014-06-19 | 미셀 테크놀로지즈, 인코포레이티드 | 제어된 형태의 약물 분말을 함유하는 중합체 코팅 |
TWI289765B (en) | 2005-07-20 | 2007-11-11 | Quanta Comp Inc | Devices a methods for signal switching and processing |
US7785647B2 (en) * | 2005-07-25 | 2010-08-31 | Advanced Cardiovascular Systems, Inc. | Methods of providing antioxidants to a drug containing product |
US20070027530A1 (en) * | 2005-07-26 | 2007-02-01 | Medtronic Vascular, Inc. | Intraluminal device, catheter assembly, and method of use thereof |
US7735449B1 (en) | 2005-07-28 | 2010-06-15 | Advanced Cardiovascular Systems, Inc. | Stent fixture having rounded support structures and method for use thereof |
WO2007016251A2 (en) * | 2005-07-28 | 2007-02-08 | Cook Incorporated | Implantable thromboresistant valve |
US7658880B2 (en) | 2005-07-29 | 2010-02-09 | Advanced Cardiovascular Systems, Inc. | Polymeric stent polishing method and apparatus |
US9101949B2 (en) * | 2005-08-04 | 2015-08-11 | Eilaz Babaev | Ultrasonic atomization and/or seperation system |
US20070031611A1 (en) * | 2005-08-04 | 2007-02-08 | Babaev Eilaz P | Ultrasound medical stent coating method and device |
US8187298B2 (en) | 2005-08-04 | 2012-05-29 | Cook Medical Technologies Llc | Embolic protection device having inflatable frame |
WO2007021749A1 (en) * | 2005-08-10 | 2007-02-22 | Med Institute, Inc. | Intraluminal device with a hollow structure |
US20080119878A1 (en) * | 2005-08-12 | 2008-05-22 | Kai Deusch | Surgical prosthesis having biodegradable and nonbiodegradable regions |
US7896539B2 (en) * | 2005-08-16 | 2011-03-01 | Bacoustics, Llc | Ultrasound apparatus and methods for mixing liquids and coating stents |
US9248034B2 (en) | 2005-08-23 | 2016-02-02 | Advanced Cardiovascular Systems, Inc. | Controlled disintegrating implantable medical devices |
US20070055352A1 (en) * | 2005-09-07 | 2007-03-08 | Wendy Naimark | Stent with pockets for containing a therapeutic agent |
US20070061006A1 (en) * | 2005-09-14 | 2007-03-15 | Nathan Desatnik | Methods of making shape memory films by chemical vapor deposition and shape memory devices made thereby |
US8377092B2 (en) | 2005-09-16 | 2013-02-19 | Cook Medical Technologies Llc | Embolic protection device |
US20070067020A1 (en) * | 2005-09-22 | 2007-03-22 | Medtronic Vasular, Inc. | Intraluminal stent, delivery system, and a method of treating a vascular condition |
US8632562B2 (en) | 2005-10-03 | 2014-01-21 | Cook Medical Technologies Llc | Embolic protection device |
US8182508B2 (en) | 2005-10-04 | 2012-05-22 | Cook Medical Technologies Llc | Embolic protection device |
US20070077435A1 (en) * | 2005-10-05 | 2007-04-05 | Schachter Deborah M | Process for coating a medical device |
CA2562580C (en) | 2005-10-07 | 2014-04-29 | Inrad, Inc. | Drug-eluting tissue marker |
US8252017B2 (en) | 2005-10-18 | 2012-08-28 | Cook Medical Technologies Llc | Invertible filter for embolic protection |
EP1942942A2 (en) * | 2005-10-31 | 2008-07-16 | Government of the United States of America, Represented by the Secretary, Department of Health and Human Services | Polysaccharide-derived nitric oxide-releasing carbon-bound diazeniumdiolates |
US8216269B2 (en) | 2005-11-02 | 2012-07-10 | Cook Medical Technologies Llc | Embolic protection device having reduced profile |
US8152831B2 (en) | 2005-11-17 | 2012-04-10 | Cook Medical Technologies Llc | Foam embolic protection device |
US20070118210A1 (en) * | 2005-11-18 | 2007-05-24 | Leonard Pinchuk | Trileaflet Heart Valve |
US7799035B2 (en) * | 2005-11-18 | 2010-09-21 | Carefusion 2200, Inc. | Device, system and method for delivering a curable material into bone |
US8690884B2 (en) | 2005-11-18 | 2014-04-08 | Carefusion 2200, Inc. | Multistate-curvature device and method for delivering a curable material into bone |
US20070128342A1 (en) * | 2005-12-02 | 2007-06-07 | Stenzel Eric B | Method and system for coating a medical device |
US20070128246A1 (en) * | 2005-12-06 | 2007-06-07 | Hossainy Syed F A | Solventless method for forming a coating |
US20070135909A1 (en) * | 2005-12-08 | 2007-06-14 | Desnoyer Jessica R | Adhesion polymers to improve stent retention |
US20070142892A1 (en) * | 2005-12-15 | 2007-06-21 | Vipul Bhupendra Dave | Self-expanding stent delivery system |
US7225825B1 (en) * | 2005-12-15 | 2007-06-05 | Hartman Brian T | Valve seal and method of installing a valve seal |
US7591841B2 (en) | 2005-12-16 | 2009-09-22 | Advanced Cardiovascular Systems, Inc. | Implantable devices for accelerated healing |
US7976891B1 (en) | 2005-12-16 | 2011-07-12 | Advanced Cardiovascular Systems, Inc. | Abluminal stent coating apparatus and method of using focused acoustic energy |
US7867547B2 (en) | 2005-12-19 | 2011-01-11 | Advanced Cardiovascular Systems, Inc. | Selectively coating luminal surfaces of stents |
US7638156B1 (en) | 2005-12-19 | 2009-12-29 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for selectively coating a medical article |
US20070148251A1 (en) * | 2005-12-22 | 2007-06-28 | Hossainy Syed F A | Nanoparticle releasing medical devices |
US7540881B2 (en) | 2005-12-22 | 2009-06-02 | Boston Scientific Scimed, Inc. | Bifurcation stent pattern |
US9308077B2 (en) * | 2005-12-23 | 2016-04-12 | Vysera Biomedical Limited | Medical device suitable for treating reflux from a stomach to an oesophagus |
US20070148390A1 (en) * | 2005-12-27 | 2007-06-28 | Specialty Coating Systems, Inc. | Fluorinated coatings |
WO2007081530A2 (en) * | 2006-01-03 | 2007-07-19 | Med Institute, Inc. | Endoluminal medical device for local delivery of cathepsin inhibitors |
US20070156230A1 (en) | 2006-01-04 | 2007-07-05 | Dugan Stephen R | Stents with radiopaque markers |
US20080286325A1 (en) * | 2006-01-05 | 2008-11-20 | Med Institute, Inc. | Cyclodextrin elution media for medical device coatings comprising a taxane therapeutic agent |
US7919108B2 (en) * | 2006-03-10 | 2011-04-05 | Cook Incorporated | Taxane coatings for implantable medical devices |
US8840660B2 (en) | 2006-01-05 | 2014-09-23 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
US7951185B1 (en) | 2006-01-06 | 2011-05-31 | Advanced Cardiovascular Systems, Inc. | Delivery of a stent at an elevated temperature |
US20100057179A1 (en) * | 2006-01-30 | 2010-03-04 | Chameleon Scientific Corporation | Conductive metal thin coatings for implantable medical sensing devices |
US9422622B2 (en) | 2006-01-30 | 2016-08-23 | Surfatek Llc | Flexible conductive single wire |
CA2641117C (en) * | 2006-01-31 | 2018-01-02 | Nanocopoeia, Inc. | Nanoparticle coating of surfaces |
US9108217B2 (en) | 2006-01-31 | 2015-08-18 | Nanocopoeia, Inc. | Nanoparticle coating of surfaces |
WO2007089881A2 (en) * | 2006-01-31 | 2007-08-09 | Regents Of The University Of Minnesota | Electrospray coating of objects |
US8089029B2 (en) | 2006-02-01 | 2012-01-03 | Boston Scientific Scimed, Inc. | Bioabsorbable metal medical device and method of manufacture |
CA2637686A1 (en) | 2006-02-02 | 2007-08-16 | Innovative Bio Therapies | An extracorporeal cell-based therapeutic device and delivery system |
US8591531B2 (en) | 2006-02-08 | 2013-11-26 | Tyrx, Inc. | Mesh pouches for implantable medical devices |
EP2114298B1 (en) | 2006-02-08 | 2022-10-19 | Medtronic, Inc. | Temporarily stiffened mesh prostheses |
US20070190104A1 (en) * | 2006-02-13 | 2007-08-16 | Kamath Kalpana R | Coating comprising an adhesive polymeric material for a medical device and method of preparing the same |
US20070191931A1 (en) * | 2006-02-16 | 2007-08-16 | Jan Weber | Bioerodible endoprostheses and methods of making the same |
US9526814B2 (en) * | 2006-02-16 | 2016-12-27 | Boston Scientific Scimed, Inc. | Medical balloons and methods of making the same |
US20070196428A1 (en) * | 2006-02-17 | 2007-08-23 | Thierry Glauser | Nitric oxide generating medical devices |
WO2007098234A2 (en) * | 2006-02-21 | 2007-08-30 | Med Institute, Inc. | Graft material for prostheses |
US8821561B2 (en) * | 2006-02-22 | 2014-09-02 | Boston Scientific Scimed, Inc. | Marker arrangement for bifurcation catheter |
US7601383B2 (en) * | 2006-02-28 | 2009-10-13 | Advanced Cardiovascular Systems, Inc. | Coating construct containing poly (vinyl alcohol) |
US7648527B2 (en) * | 2006-03-01 | 2010-01-19 | Cook Incorporated | Methods of reducing retrograde flow |
US7713637B2 (en) * | 2006-03-03 | 2010-05-11 | Advanced Cardiovascular Systems, Inc. | Coating containing PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid polymer |
US7875284B2 (en) * | 2006-03-10 | 2011-01-25 | Cook Incorporated | Methods of manufacturing and modifying taxane coatings for implantable medical devices |
US20070224235A1 (en) | 2006-03-24 | 2007-09-27 | Barron Tenney | Medical devices having nanoporous coatings for controlled therapeutic agent delivery |
US20070225795A1 (en) * | 2006-03-24 | 2007-09-27 | Juan Granada | Composite vascular prosthesis |
US8187620B2 (en) | 2006-03-27 | 2012-05-29 | Boston Scientific Scimed, Inc. | Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents |
EP1839688A1 (en) * | 2006-03-28 | 2007-10-03 | Universität Zürich | Drug-eluting clinical device |
US20070231361A1 (en) * | 2006-03-28 | 2007-10-04 | Medtronic Vascular, Inc. | Use of Fatty Acids to Inhibit the Growth of Aneurysms |
US20070231363A1 (en) * | 2006-03-29 | 2007-10-04 | Yung-Ming Chen | Coatings formed from stimulus-sensitive material |
US7964210B2 (en) | 2006-03-31 | 2011-06-21 | Abbott Cardiovascular Systems Inc. | Degradable polymeric implantable medical devices with a continuous phase and discrete phase |
US8048150B2 (en) | 2006-04-12 | 2011-11-01 | Boston Scientific Scimed, Inc. | Endoprosthesis having a fiber meshwork disposed thereon |
US9017361B2 (en) | 2006-04-20 | 2015-04-28 | Covidien Lp | Occlusive implant and methods for hollow anatomical structure |
EP2015846A2 (en) | 2006-04-24 | 2009-01-21 | Ekos Corporation | Ultrasound therapy system |
US8303648B2 (en) * | 2006-04-25 | 2012-11-06 | Cook Medical Technologies Llc | Artificial venous valve containing therapeutic agent |
AU2007243268B2 (en) | 2006-04-26 | 2013-06-13 | Micell Technologies, Inc. | Coatings containing multiple drugs |
US20070259101A1 (en) * | 2006-05-02 | 2007-11-08 | Kleiner Lothar W | Microporous coating on medical devices |
US8069814B2 (en) | 2006-05-04 | 2011-12-06 | Advanced Cardiovascular Systems, Inc. | Stent support devices |
US8304012B2 (en) * | 2006-05-04 | 2012-11-06 | Advanced Cardiovascular Systems, Inc. | Method for drying a stent |
US7985441B1 (en) | 2006-05-04 | 2011-07-26 | Yiwen Tang | Purification of polymers for coating applications |
US20070275035A1 (en) * | 2006-05-24 | 2007-11-29 | Microchips, Inc. | Minimally Invasive Medical Implant Devices for Controlled Drug Delivery |
US7761968B2 (en) | 2006-05-25 | 2010-07-27 | Advanced Cardiovascular Systems, Inc. | Method of crimping a polymeric stent |
US20070276486A1 (en) * | 2006-05-25 | 2007-11-29 | E. Benson Hood Laboratories | Coated tracheostomy tube and stoma stent or cannula |
US8752268B2 (en) | 2006-05-26 | 2014-06-17 | Abbott Cardiovascular Systems Inc. | Method of making stents with radiopaque markers |
US7951194B2 (en) | 2006-05-26 | 2011-05-31 | Abbott Cardiovascular Sysetms Inc. | Bioabsorbable stent with radiopaque coating |
US7775178B2 (en) * | 2006-05-26 | 2010-08-17 | Advanced Cardiovascular Systems, Inc. | Stent coating apparatus and method |
US7959940B2 (en) | 2006-05-30 | 2011-06-14 | Advanced Cardiovascular Systems, Inc. | Polymer-bioceramic composite implantable medical devices |
US7842737B2 (en) | 2006-09-29 | 2010-11-30 | Abbott Cardiovascular Systems Inc. | Polymer blend-bioceramic composite implantable medical devices |
US8343530B2 (en) | 2006-05-30 | 2013-01-01 | Abbott Cardiovascular Systems Inc. | Polymer-and polymer blend-bioceramic composite implantable medical devices |
US8568764B2 (en) * | 2006-05-31 | 2013-10-29 | Advanced Cardiovascular Systems, Inc. | Methods of forming coating layers for medical devices utilizing flash vaporization |
US9561351B2 (en) * | 2006-05-31 | 2017-02-07 | Advanced Cardiovascular Systems, Inc. | Drug delivery spiral coil construct |
US8486135B2 (en) | 2006-06-01 | 2013-07-16 | Abbott Cardiovascular Systems Inc. | Implantable medical devices fabricated from branched polymers |
US8034287B2 (en) | 2006-06-01 | 2011-10-11 | Abbott Cardiovascular Systems Inc. | Radiation sterilization of medical devices |
US8703167B2 (en) | 2006-06-05 | 2014-04-22 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical devices for controlled release of a hydrophilic drug and a hydrophobic drug |
US8778376B2 (en) | 2006-06-09 | 2014-07-15 | Advanced Cardiovascular Systems, Inc. | Copolymer comprising elastin pentapeptide block and hydrophilic block, and medical device and method of treating |
US20070286882A1 (en) * | 2006-06-09 | 2007-12-13 | Yiwen Tang | Solvent systems for coating medical devices |
US11039942B2 (en) * | 2006-06-13 | 2021-06-22 | Sino Medical Sciences Technology Inc. | Drug eluting stent and method of use of the same for enabling restoration of functional endothelial cell layers |
US20080095918A1 (en) * | 2006-06-14 | 2008-04-24 | Kleiner Lothar W | Coating construct with enhanced interfacial compatibility |
US8114150B2 (en) | 2006-06-14 | 2012-02-14 | Advanced Cardiovascular Systems, Inc. | RGD peptide attached to bioabsorbable stents |
US8603530B2 (en) | 2006-06-14 | 2013-12-10 | Abbott Cardiovascular Systems Inc. | Nanoshell therapy |
KR101443926B1 (ko) | 2006-06-15 | 2014-10-02 | 마이크로벤션, 인코포레이티드 | 팽창성 중합체로 제조된 색전술용 장치 |
US8048448B2 (en) | 2006-06-15 | 2011-11-01 | Abbott Cardiovascular Systems Inc. | Nanoshells for drug delivery |
US8535372B1 (en) | 2006-06-16 | 2013-09-17 | Abbott Cardiovascular Systems Inc. | Bioabsorbable stent with prohealing layer |
US8048168B2 (en) * | 2006-06-16 | 2011-11-01 | Boston Scientific Scimed, Inc. | Partially soluble implantable or insertable medical devices |
US8333000B2 (en) | 2006-06-19 | 2012-12-18 | Advanced Cardiovascular Systems, Inc. | Methods for improving stent retention on a balloon catheter |
US8017237B2 (en) | 2006-06-23 | 2011-09-13 | Abbott Cardiovascular Systems, Inc. | Nanoshells on polymers |
US9072820B2 (en) | 2006-06-26 | 2015-07-07 | Advanced Cardiovascular Systems, Inc. | Polymer composite stent with polymer particles |
US8128688B2 (en) | 2006-06-27 | 2012-03-06 | Abbott Cardiovascular Systems Inc. | Carbon coating on an implantable device |
US8815275B2 (en) | 2006-06-28 | 2014-08-26 | Boston Scientific Scimed, Inc. | Coatings for medical devices comprising a therapeutic agent and a metallic material |
US8956640B2 (en) * | 2006-06-29 | 2015-02-17 | Advanced Cardiovascular Systems, Inc. | Block copolymers including a methoxyethyl methacrylate midblock |
US7794776B1 (en) | 2006-06-29 | 2010-09-14 | Abbott Cardiovascular Systems Inc. | Modification of polymer stents with radiation |
WO2008002778A2 (en) | 2006-06-29 | 2008-01-03 | Boston Scientific Limited | Medical devices with selective coating |
US7740791B2 (en) | 2006-06-30 | 2010-06-22 | Advanced Cardiovascular Systems, Inc. | Method of fabricating a stent with features by blow molding |
BRPI0722412B8 (pt) * | 2006-07-03 | 2021-06-22 | Hemoteq Ag | uso de uma composição consistindo em rapamicina ou rapamicina e paclitaxel e cateter balão |
US20080008736A1 (en) * | 2006-07-06 | 2008-01-10 | Thierry Glauser | Random copolymers of methacrylates and acrylates |
US9028859B2 (en) * | 2006-07-07 | 2015-05-12 | Advanced Cardiovascular Systems, Inc. | Phase-separated block copolymer coatings for implantable medical devices |
US7823263B2 (en) | 2006-07-11 | 2010-11-02 | Abbott Cardiovascular Systems Inc. | Method of removing stent islands from a stent |
WO2008008291A2 (en) * | 2006-07-13 | 2008-01-17 | Icon Medical Corp. | Stent |
US7998404B2 (en) | 2006-07-13 | 2011-08-16 | Advanced Cardiovascular Systems, Inc. | Reduced temperature sterilization of stents |
US7757543B2 (en) | 2006-07-13 | 2010-07-20 | Advanced Cardiovascular Systems, Inc. | Radio frequency identification monitoring of stents |
US8685430B1 (en) | 2006-07-14 | 2014-04-01 | Abbott Cardiovascular Systems Inc. | Tailored aliphatic polyesters for stent coatings |
US7794495B2 (en) | 2006-07-17 | 2010-09-14 | Advanced Cardiovascular Systems, Inc. | Controlled degradation of stents |
US7886419B2 (en) | 2006-07-18 | 2011-02-15 | Advanced Cardiovascular Systems, Inc. | Stent crimping apparatus and method |
US8016879B2 (en) | 2006-08-01 | 2011-09-13 | Abbott Cardiovascular Systems Inc. | Drug delivery after biodegradation of the stent scaffolding |
WO2008017028A2 (en) | 2006-08-02 | 2008-02-07 | Boston Scientific Scimed, Inc. | Endoprosthesis with three-dimensional disintegration control |
US8703169B1 (en) | 2006-08-15 | 2014-04-22 | Abbott Cardiovascular Systems Inc. | Implantable device having a coating comprising carrageenan and a biostable polymer |
US20080171087A1 (en) * | 2006-08-16 | 2008-07-17 | Chappa Ralph A | Methods and materials for increasing the adhesion of elution control matrices to substrates |
US9173733B1 (en) | 2006-08-21 | 2015-11-03 | Abbott Cardiovascular Systems Inc. | Tracheobronchial implantable medical device and methods of use |
AU2007290217B2 (en) * | 2006-08-28 | 2012-10-11 | Cook Medical Technologies Llc | Stent with antimicrobial drainage lumen surface |
US7923022B2 (en) | 2006-09-13 | 2011-04-12 | Advanced Cardiovascular Systems, Inc. | Degradable polymeric implantable medical devices with continuous phase and discrete phase |
WO2008033711A2 (en) | 2006-09-14 | 2008-03-20 | Boston Scientific Limited | Medical devices with drug-eluting coating |
ES2368125T3 (es) | 2006-09-15 | 2011-11-14 | Boston Scientific Scimed, Inc. | Endoprótesis bioerosionable con capas inorgánicas bioestables. |
US8057534B2 (en) * | 2006-09-15 | 2011-11-15 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
JP2010503485A (ja) | 2006-09-15 | 2010-02-04 | ボストン サイエンティフィック リミテッド | 医療用デバイスおよび同デバイスの製造方法 |
JP2010503489A (ja) | 2006-09-15 | 2010-02-04 | ボストン サイエンティフィック リミテッド | 生体内分解性内部人工器官およびその製造方法 |
WO2008034047A2 (en) | 2006-09-15 | 2008-03-20 | Boston Scientific Limited | Endoprosthesis with adjustable surface features |
CA2663762A1 (en) | 2006-09-18 | 2008-03-27 | Boston Scientific Limited | Endoprostheses |
US20080071307A1 (en) | 2006-09-19 | 2008-03-20 | Cook Incorporated | Apparatus and methods for in situ embolic protection |
US7963942B2 (en) * | 2006-09-20 | 2011-06-21 | Boston Scientific Scimed, Inc. | Medical balloons with modified surfaces |
US7875069B2 (en) * | 2006-09-21 | 2011-01-25 | Boston Scientific Scimed, Inc. | Stent with support element |
JP2010504174A (ja) * | 2006-09-21 | 2010-02-12 | クレベニー テクノロジーズ | タングステン、ジルコニウム、タンタル、および/または、ニオブの固有特性を利用する一定の設計特徴を備えた、特別に構成され表面修飾された医療機器 |
WO2008039749A2 (en) * | 2006-09-25 | 2008-04-03 | Surmodics, Inc. | Multi-layered coatings and methods for controlling elution of active agents |
US20080075779A1 (en) * | 2006-09-27 | 2008-03-27 | Chappa Ralph A | Additives And Methods For Enhancing Active Agent Elution Kinetics |
US7951191B2 (en) | 2006-10-10 | 2011-05-31 | Boston Scientific Scimed, Inc. | Bifurcated stent with entire circumferential petal |
US20080097591A1 (en) * | 2006-10-20 | 2008-04-24 | Biosensors International Group | Drug-delivery endovascular stent and method of use |
US8067055B2 (en) * | 2006-10-20 | 2011-11-29 | Biosensors International Group, Ltd. | Drug-delivery endovascular stent and method of use |
US8064987B2 (en) | 2006-10-23 | 2011-11-22 | C. R. Bard, Inc. | Breast marker |
WO2008052000A2 (en) | 2006-10-23 | 2008-05-02 | Micell Technologies, Inc. | Holder for electrically charging a substrate during coating |
US20080103584A1 (en) * | 2006-10-25 | 2008-05-01 | Biosensors International Group | Temporal Intraluminal Stent, Methods of Making and Using |
EP2078052B1 (en) | 2006-10-31 | 2010-07-28 | Surmodics Pharmaceuticals, Inc. | Spheronized polymer particles |
US9023114B2 (en) * | 2006-11-06 | 2015-05-05 | Tyrx, Inc. | Resorbable pouches for implantable medical devices |
US7981150B2 (en) | 2006-11-09 | 2011-07-19 | Boston Scientific Scimed, Inc. | Endoprosthesis with coatings |
US7842082B2 (en) | 2006-11-16 | 2010-11-30 | Boston Scientific Scimed, Inc. | Bifurcated stent |
US8414526B2 (en) * | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids |
US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US8414910B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
US8414909B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US8425459B2 (en) | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
US8998846B2 (en) | 2006-11-20 | 2015-04-07 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US7713541B1 (en) * | 2006-11-21 | 2010-05-11 | Abbott Cardiovascular Systems Inc. | Zwitterionic terpolymers, method of making and use on medical devices |
US20080118541A1 (en) * | 2006-11-21 | 2008-05-22 | Abbott Laboratories | Use of a terpolymer of tetrafluoroethylene, hexafluoropropylene, and vinylidene fluoride in drug eluting coatings on medical devices |
EP2097119A4 (en) * | 2006-11-21 | 2012-10-17 | Abbott Lab | USE OF A TERPOLYMER OF TETRAFLUOROETHYLENE, HEXAFLUORPROPYLENE AND VINYLIDENE FLUORIDE IN MEDICAMENTAL COATINGS |
US9040816B2 (en) * | 2006-12-08 | 2015-05-26 | Nanocopoeia, Inc. | Methods and apparatus for forming photovoltaic cells using electrospray |
US9579077B2 (en) | 2006-12-12 | 2017-02-28 | C.R. Bard, Inc. | Multiple imaging mode tissue marker |
US8099849B2 (en) | 2006-12-13 | 2012-01-24 | Abbott Cardiovascular Systems Inc. | Optimizing fracture toughness of polymeric stent |
US8597673B2 (en) * | 2006-12-13 | 2013-12-03 | Advanced Cardiovascular Systems, Inc. | Coating of fast absorption or dissolution |
US20080142616A1 (en) * | 2006-12-15 | 2008-06-19 | Bacoustics Llc | Method of Producing a Directed Spray |
US8017141B2 (en) | 2006-12-15 | 2011-09-13 | Advanced Cardiovascular Systems, Inc. | Coatings of acrylamide-based copolymers |
ES2432572T3 (es) | 2006-12-18 | 2013-12-04 | C.R. Bard, Inc. | Marcador de biopsia con propiedades de obtención de imágenes generadas in situ |
US9474833B2 (en) * | 2006-12-18 | 2016-10-25 | Cook Medical Technologies Llc | Stent graft with releasable therapeutic agent and soluble coating |
EP2277563B1 (en) | 2006-12-28 | 2014-06-25 | Boston Scientific Limited | Bioerodible endoprostheses and method of making the same |
US11426494B2 (en) | 2007-01-08 | 2022-08-30 | MT Acquisition Holdings LLC | Stents having biodegradable layers |
JP5603598B2 (ja) | 2007-01-08 | 2014-10-08 | ミセル テクノロジーズ、インコーポレイテッド | 生物分解層を有するステント |
US10182833B2 (en) | 2007-01-08 | 2019-01-22 | Ekos Corporation | Power parameters for ultrasonic catheter |
EP2101683A4 (en) * | 2007-01-11 | 2014-12-03 | Robert Lamar Bjork Jr | KORONARARTERIENSTENT FOR THE RELEASE OF SEVERAL MEDICAMENTS AND FOR PERCUTANEOUS CORONARTERIES |
US9339593B2 (en) * | 2007-01-11 | 2016-05-17 | Robert L. Bjork, JR. | Drug-eluting coronary artery stent coated with anti-platelet-derived growth factor antibodies overlaying extracellular matrix proteins with an outer coating of anti-inflammatory (calcineurin inhibitor) and/or anti-proliferatives |
ES2409759T3 (es) * | 2007-01-21 | 2013-06-27 | Hemoteq Ag | Producto médico para el tratamiento de la estenosis de los canales del cuerpo y para la prevención de la estenosis amenazante |
EP2125058B1 (en) | 2007-02-07 | 2014-12-03 | Cook Medical Technologies LLC | Medical device coatings for releasing a therapeutic agent at multiple rates |
US9526642B2 (en) * | 2007-02-09 | 2016-12-27 | Taheri Laduca Llc | Vascular implants and methods of fabricating the same |
US7854941B2 (en) * | 2007-02-12 | 2010-12-21 | The University Of Southern Mississippi | Method of attaching drug compounds to non-reactive polymer surfaces |
US9901434B2 (en) | 2007-02-27 | 2018-02-27 | Cook Medical Technologies Llc | Embolic protection device including a Z-stent waist band |
US8070797B2 (en) | 2007-03-01 | 2011-12-06 | Boston Scientific Scimed, Inc. | Medical device with a porous surface for delivery of a therapeutic agent |
US8431149B2 (en) | 2007-03-01 | 2013-04-30 | Boston Scientific Scimed, Inc. | Coated medical devices for abluminal drug delivery |
EP2134409A4 (en) * | 2007-03-09 | 2013-07-17 | Anthem Orthopaedics Llc | IMPLANTABLE MEDICINAL PRODUCT AND METHOD AND METHOD FOR THE APPLICATION THEREOF |
US8646444B2 (en) * | 2007-03-27 | 2014-02-11 | Electrolux Home Products, Inc. | Glide rack |
WO2008122044A2 (en) * | 2007-04-02 | 2008-10-09 | Georgia Tech Research Corporation | Implantable device for communicating with biological tissue |
US20080249605A1 (en) * | 2007-04-04 | 2008-10-09 | Vipul Dave | Bioabsorbable Polymer, Non-Bioabsorbable Metal Composite Stents |
US8067054B2 (en) | 2007-04-05 | 2011-11-29 | Boston Scientific Scimed, Inc. | Stents with ceramic drug reservoir layer and methods of making and using the same |
US8262723B2 (en) | 2007-04-09 | 2012-09-11 | Abbott Cardiovascular Systems Inc. | Implantable medical devices fabricated from polymer blends with star-block copolymers |
WO2008127966A1 (en) * | 2007-04-11 | 2008-10-23 | Boston Scientific Scimed, Inc. | Photoresist coating to apply a coating to select areas of a medical device |
SG183035A1 (en) * | 2007-04-17 | 2012-08-30 | Micell Technologies Inc | Stents having biodegradable layers |
US7947301B2 (en) | 2007-04-17 | 2011-05-24 | Medtronic, Inc. | Reduction of infection associated with medical device |
US9034367B2 (en) * | 2007-05-10 | 2015-05-19 | Cormatrix Cardiovascular, Inc. | Articles for tissue regeneration with biodegradable polymer |
US20080286332A1 (en) | 2007-05-14 | 2008-11-20 | Pacetti Stephen D | Implantable medical devices with a topcoat layer of phosphoryl choline acrylate polymer for reduced thrombosis, and improved mechanical properties |
US8147769B1 (en) | 2007-05-16 | 2012-04-03 | Abbott Cardiovascular Systems Inc. | Stent and delivery system with reduced chemical degradation |
US20200037875A1 (en) | 2007-05-18 | 2020-02-06 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
US7976915B2 (en) | 2007-05-23 | 2011-07-12 | Boston Scientific Scimed, Inc. | Endoprosthesis with select ceramic morphology |
WO2008148013A1 (en) | 2007-05-25 | 2008-12-04 | Micell Technologies, Inc. | Polymer films for medical device coating |
US9056155B1 (en) | 2007-05-29 | 2015-06-16 | Abbott Cardiovascular Systems Inc. | Coatings having an elastic primer layer |
US7829008B2 (en) | 2007-05-30 | 2010-11-09 | Abbott Cardiovascular Systems Inc. | Fabricating a stent from a blow molded tube |
US7959857B2 (en) | 2007-06-01 | 2011-06-14 | Abbott Cardiovascular Systems Inc. | Radiation sterilization of medical devices |
US8202528B2 (en) | 2007-06-05 | 2012-06-19 | Abbott Cardiovascular Systems Inc. | Implantable medical devices with elastomeric block copolymer coatings |
US8293260B2 (en) | 2007-06-05 | 2012-10-23 | Abbott Cardiovascular Systems Inc. | Elastomeric copolymer coatings containing poly (tetramethyl carbonate) for implantable medical devices |
CA2688184A1 (en) | 2007-06-08 | 2008-12-18 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
US8425591B1 (en) | 2007-06-11 | 2013-04-23 | Abbott Cardiovascular Systems Inc. | Methods of forming polymer-bioceramic composite medical devices with bioceramic particles |
EP2494932B1 (en) | 2007-06-22 | 2020-05-20 | Ekos Corporation | Apparatus for treatment of intracranial hemorrhages |
EP2162101B1 (en) * | 2007-06-25 | 2019-02-20 | MicroVention, Inc. | Self-expanding prosthesis |
US8109904B1 (en) | 2007-06-25 | 2012-02-07 | Abbott Cardiovascular Systems Inc. | Drug delivery medical devices |
US8048441B2 (en) | 2007-06-25 | 2011-11-01 | Abbott Cardiovascular Systems, Inc. | Nanobead releasing medical devices |
US7901452B2 (en) | 2007-06-27 | 2011-03-08 | Abbott Cardiovascular Systems Inc. | Method to fabricate a stent having selected morphology to reduce restenosis |
US7955381B1 (en) | 2007-06-29 | 2011-06-07 | Advanced Cardiovascular Systems, Inc. | Polymer-bioceramic composite implantable medical device with different types of bioceramic particles |
US9192697B2 (en) | 2007-07-03 | 2015-11-24 | Hemoteq Ag | Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis |
EP2173400B1 (en) * | 2007-07-06 | 2013-11-20 | Boston Scientific Scimed, Inc. | Implantable medical devices having adjustable pore volume and methods for making the same |
US7942926B2 (en) * | 2007-07-11 | 2011-05-17 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US8002823B2 (en) | 2007-07-11 | 2011-08-23 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US7780095B2 (en) | 2007-07-13 | 2010-08-24 | Bacoustics, Llc | Ultrasound pumping apparatus |
US7753285B2 (en) | 2007-07-13 | 2010-07-13 | Bacoustics, Llc | Echoing ultrasound atomization and/or mixing system |
JP2010533563A (ja) | 2007-07-19 | 2010-10-28 | ボストン サイエンティフィック リミテッド | 吸着抑制表面を有する内部人工器官 |
US20090026924A1 (en) * | 2007-07-23 | 2009-01-29 | Leung Roger Y | Methods of making low-refractive index and/or low-k organosilicate coatings |
US8815273B2 (en) | 2007-07-27 | 2014-08-26 | Boston Scientific Scimed, Inc. | Drug eluting medical devices having porous layers |
US7931683B2 (en) | 2007-07-27 | 2011-04-26 | Boston Scientific Scimed, Inc. | Articles having ceramic coated surfaces |
US8221822B2 (en) | 2007-07-31 | 2012-07-17 | Boston Scientific Scimed, Inc. | Medical device coating by laser cladding |
US8486134B2 (en) | 2007-08-01 | 2013-07-16 | Boston Scientific Scimed, Inc. | Bifurcation treatment system and methods |
JP2010535541A (ja) | 2007-08-03 | 2010-11-25 | ボストン サイエンティフィック リミテッド | 広い表面積を有する医療器具用のコーティング |
US20090041845A1 (en) * | 2007-08-08 | 2009-02-12 | Lothar Walter Kleiner | Implantable medical devices having thin absorbable coatings |
US8271101B2 (en) * | 2007-08-29 | 2012-09-18 | Advanced Bionics | Modular drug delivery system for minimizing trauma during and after insertion of a cochlear lead |
US8190271B2 (en) * | 2007-08-29 | 2012-05-29 | Advanced Bionics, Llc | Minimizing trauma during and after insertion of a cochlear lead |
US7959669B2 (en) | 2007-09-12 | 2011-06-14 | Boston Scientific Scimed, Inc. | Bifurcated stent with open ended side branch support |
US8052745B2 (en) | 2007-09-13 | 2011-11-08 | Boston Scientific Scimed, Inc. | Endoprosthesis |
US8419748B2 (en) | 2007-09-14 | 2013-04-16 | Cook Medical Technologies Llc | Helical thrombus removal device |
JP2010539245A (ja) | 2007-09-14 | 2010-12-16 | 日東電工株式会社 | 薬物担体 |
US8252018B2 (en) | 2007-09-14 | 2012-08-28 | Cook Medical Technologies Llc | Helical embolic protection device |
US9138307B2 (en) | 2007-09-14 | 2015-09-22 | Cook Medical Technologies Llc | Expandable device for treatment of a stricture in a body vessel |
US8360995B2 (en) * | 2007-09-18 | 2013-01-29 | Cook Medical Technologies Llc | Wire guide |
US20090076591A1 (en) * | 2007-09-19 | 2009-03-19 | Boston Scientific Scimed, Inc. | Stent Design Allowing Extended Release of Drug and/or Enhanced Adhesion of Polymer to OD Surface |
KR100930167B1 (ko) * | 2007-09-19 | 2009-12-07 | 삼성전기주식회사 | 초광각 광학계 |
US8226701B2 (en) | 2007-09-26 | 2012-07-24 | Trivascular, Inc. | Stent and delivery system for deployment thereof |
US8663309B2 (en) | 2007-09-26 | 2014-03-04 | Trivascular, Inc. | Asymmetric stent apparatus and method |
US8066755B2 (en) | 2007-09-26 | 2011-11-29 | Trivascular, Inc. | System and method of pivoted stent deployment |
EP2194921B1 (en) | 2007-10-04 | 2018-08-29 | TriVascular, Inc. | Modular vascular graft for low profile percutaneous delivery |
US9452258B2 (en) | 2007-10-09 | 2016-09-27 | Dexcom, Inc. | Integrated insulin delivery system with continuous glucose sensor |
GB2456747A (en) * | 2007-10-12 | 2009-07-29 | Laryngeal Mask Co Ltd | Laryngeal mask airway device with a parylene coating |
WO2009051780A1 (en) * | 2007-10-19 | 2009-04-23 | Micell Technologies, Inc. | Drug coated stents |
US8142490B2 (en) | 2007-10-24 | 2012-03-27 | Cordis Corporation | Stent segments axially connected by thin film |
US8029554B2 (en) | 2007-11-02 | 2011-10-04 | Boston Scientific Scimed, Inc. | Stent with embedded material |
US7938855B2 (en) | 2007-11-02 | 2011-05-10 | Boston Scientific Scimed, Inc. | Deformable underlayer for stent |
US8216632B2 (en) | 2007-11-02 | 2012-07-10 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
AU2008322469B2 (en) | 2007-11-14 | 2014-02-20 | Biosensors International Group, Ltd. | Automated coating apparatus and method |
US8328861B2 (en) | 2007-11-16 | 2012-12-11 | Trivascular, Inc. | Delivery system and method for bifurcated graft |
US8083789B2 (en) | 2007-11-16 | 2011-12-27 | Trivascular, Inc. | Securement assembly and method for expandable endovascular device |
US7833266B2 (en) * | 2007-11-28 | 2010-11-16 | Boston Scientific Scimed, Inc. | Bifurcated stent with drug wells for specific ostial, carina, and side branch treatment |
US8679176B2 (en) | 2007-12-18 | 2014-03-25 | Cormatrix Cardiovascular, Inc | Prosthetic tissue valve |
US8257434B2 (en) | 2007-12-18 | 2012-09-04 | Cormatrix Cardiovascular, Inc. | Prosthetic tissue valve |
US7722661B2 (en) | 2007-12-19 | 2010-05-25 | Boston Scientific Scimed, Inc. | Stent |
US8211489B2 (en) * | 2007-12-19 | 2012-07-03 | Abbott Cardiovascular Systems, Inc. | Methods for applying an application material to an implantable device |
US8361538B2 (en) | 2007-12-19 | 2013-01-29 | Abbott Laboratories | Methods for applying an application material to an implantable device |
EP2231215B1 (en) | 2007-12-21 | 2019-01-30 | MicroVention, Inc. | Hydrogel filaments for biomedical uses |
US8277501B2 (en) | 2007-12-21 | 2012-10-02 | Boston Scientific Scimed, Inc. | Bi-stable bifurcated stent petal geometry |
US8747456B2 (en) | 2007-12-31 | 2014-06-10 | Boston Scientific Scimed, Inc. | Bifurcation stent delivery system and methods |
US20090192580A1 (en) * | 2008-01-28 | 2009-07-30 | Shrojalkumar Desai | Medical electrical lead with biocompatible lead body coating |
US20090192577A1 (en) * | 2008-01-28 | 2009-07-30 | Shrojalkumar Desai | Medical electrical lead with coated conductor |
KR100988816B1 (ko) * | 2008-01-29 | 2010-10-20 | 신경민 | 담즙관용 이중 피막형 스텐트 |
WO2009099767A2 (en) | 2008-01-31 | 2009-08-13 | C.R. Bard, Inc. | Biopsy tissue marker |
WO2009099935A2 (en) * | 2008-02-01 | 2009-08-13 | Boston Scientific Scimed, Inc. | Drug-coated medical devices for differential drug release |
US8682408B2 (en) | 2008-03-28 | 2014-03-25 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
US8583204B2 (en) | 2008-03-28 | 2013-11-12 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
US11730407B2 (en) | 2008-03-28 | 2023-08-22 | Dexcom, Inc. | Polymer membranes for continuous analyte sensors |
BRPI0910969B8 (pt) * | 2008-04-17 | 2021-06-22 | Micell Technologies Inc | dispositivo |
JP5581311B2 (ja) | 2008-04-22 | 2014-08-27 | ボストン サイエンティフィック サイムド,インコーポレイテッド | 無機材料のコーティングを有する医療デバイス及びその製造方法 |
WO2009132176A2 (en) | 2008-04-24 | 2009-10-29 | Boston Scientific Scimed, Inc. | Medical devices having inorganic particle layers |
WO2009135125A2 (en) | 2008-05-01 | 2009-11-05 | Bayer Schering Pharma Ag | Catheter balloon drug adherence techniques and methods |
US7998192B2 (en) | 2008-05-09 | 2011-08-16 | Boston Scientific Scimed, Inc. | Endoprostheses |
US8932340B2 (en) | 2008-05-29 | 2015-01-13 | Boston Scientific Scimed, Inc. | Bifurcated stent and delivery system |
US8377108B2 (en) | 2008-06-02 | 2013-02-19 | Boston Scientific Scimed, Inc. | Staggered two balloon bifurcation catheter assembly and methods |
JP5662310B2 (ja) * | 2008-06-05 | 2015-01-28 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | 収縮可能な分岐装置およびその製造方法 |
WO2009149405A1 (en) * | 2008-06-05 | 2009-12-10 | Boston Scientific Scimed, Inc. | Balloon bifurcated lumen treatment |
US8236046B2 (en) | 2008-06-10 | 2012-08-07 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis |
JP5657529B2 (ja) * | 2008-06-13 | 2015-01-21 | スミス アンド ネフュー インコーポレーテッドSmith & Nephew,Inc. | 組織の修復のための固定デバイス |
WO2009155328A2 (en) | 2008-06-18 | 2009-12-23 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
CA2728215A1 (en) * | 2008-06-18 | 2010-06-24 | Innovative Biotherapies, Inc. | Methods for enhanced propagation of cells |
EP2331018B1 (en) | 2008-06-20 | 2021-11-17 | Coloplast A/S | Intraluminal device |
US20090319026A1 (en) * | 2008-06-20 | 2009-12-24 | Boston Scientific Scimed, Inc. | Composite Stent with Reservoirs for Drug Delivery and Methods of Manufacturing |
US20110160836A1 (en) * | 2008-06-20 | 2011-06-30 | Vysera Biomedical Limited | Valve device |
US20100114327A1 (en) * | 2008-06-20 | 2010-05-06 | Vysera Biomedical Limited | Valve |
US8277506B2 (en) | 2008-06-24 | 2012-10-02 | Carefusion 2200, Inc. | Method and structure for stabilizing a vertebral body |
JP2011528275A (ja) | 2008-07-17 | 2011-11-17 | ミセル テクノロジーズ,インク. | 薬物送達医療デバイス |
US7951193B2 (en) * | 2008-07-23 | 2011-05-31 | Boston Scientific Scimed, Inc. | Drug-eluting stent |
DE102008040640A1 (de) * | 2008-07-23 | 2010-01-28 | Biotronik Vi Patent Ag | Endoprothese und Verfahren zur Herstellung derselben |
US7985252B2 (en) | 2008-07-30 | 2011-07-26 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis |
WO2010024898A2 (en) | 2008-08-29 | 2010-03-04 | Lutonix, Inc. | Methods and apparatuses for coating balloon catheters |
US8128951B2 (en) | 2008-09-15 | 2012-03-06 | Cv Ingenuity Corp. | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
US9198968B2 (en) * | 2008-09-15 | 2015-12-01 | The Spectranetics Corporation | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
US8114429B2 (en) | 2008-09-15 | 2012-02-14 | Cv Ingenuity Corp. | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
US8257722B2 (en) | 2008-09-15 | 2012-09-04 | Cv Ingenuity Corp. | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
US8815259B2 (en) | 2008-09-19 | 2014-08-26 | Innovative Surface Technologies, Inc. | Drug eluting superhydrophobic coatings |
EP2711031A3 (en) * | 2008-09-22 | 2014-07-02 | Boston Scientific Neuromodulation Corporation | Implantable or Insertable Medical Devices |
US9327061B2 (en) | 2008-09-23 | 2016-05-03 | Senorx, Inc. | Porous bioabsorbable implant |
US8076529B2 (en) * | 2008-09-26 | 2011-12-13 | Abbott Cardiovascular Systems, Inc. | Expandable member formed of a fibrous matrix for intraluminal drug delivery |
US8769796B2 (en) | 2008-09-25 | 2014-07-08 | Advanced Bifurcation Systems, Inc. | Selective stent crimping |
US11298252B2 (en) | 2008-09-25 | 2022-04-12 | Advanced Bifurcation Systems Inc. | Stent alignment during treatment of a bifurcation |
US8226603B2 (en) * | 2008-09-25 | 2012-07-24 | Abbott Cardiovascular Systems Inc. | Expandable member having a covering formed of a fibrous matrix for intraluminal drug delivery |
US8049061B2 (en) | 2008-09-25 | 2011-11-01 | Abbott Cardiovascular Systems, Inc. | Expandable member formed of a fibrous matrix having hydrogel polymer for intraluminal drug delivery |
US8500687B2 (en) | 2008-09-25 | 2013-08-06 | Abbott Cardiovascular Systems Inc. | Stent delivery system having a fibrous matrix covering with improved stent retention |
EP2344068B1 (en) | 2008-09-25 | 2022-10-19 | Advanced Bifurcation Systems Inc. | Partially crimped stent |
US8092822B2 (en) * | 2008-09-29 | 2012-01-10 | Abbott Cardiovascular Systems Inc. | Coatings including dexamethasone derivatives and analogs and olimus drugs |
US8382824B2 (en) | 2008-10-03 | 2013-02-26 | Boston Scientific Scimed, Inc. | Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides |
US8445008B2 (en) * | 2008-10-17 | 2013-05-21 | Medtronic, Inc. | Reduction of infection associated with medical device |
EP2365962B1 (en) | 2008-11-07 | 2017-07-05 | Massachusetts Institute of Technology | Aminoalcohol lipidoids and uses thereof |
DE102008043642A1 (de) * | 2008-11-11 | 2010-05-12 | Biotronik Vi Patent Ag | Endoprothese |
US8231980B2 (en) | 2008-12-03 | 2012-07-31 | Boston Scientific Scimed, Inc. | Medical implants including iridium oxide |
US8551517B2 (en) * | 2008-12-16 | 2013-10-08 | Kimberly-Clark Worldwide, Inc. | Substrates providing multiple releases of active agents |
US8834913B2 (en) * | 2008-12-26 | 2014-09-16 | Battelle Memorial Institute | Medical implants and methods of making medical implants |
US8388644B2 (en) | 2008-12-29 | 2013-03-05 | Cook Medical Technologies Llc | Embolic protection device and method of use |
KR101087088B1 (ko) * | 2008-12-29 | 2011-11-25 | 한국과학기술연구원 | 나노 구조 패턴을 갖는 약물 방출용 스텐트의 제조방법 및 이로부터 제조된 약물 방출용 스텐트 |
WO2010077244A1 (en) | 2008-12-30 | 2010-07-08 | C.R. Bard Inc. | Marker delivery device for tissue marker placement |
US8623395B2 (en) | 2010-01-29 | 2014-01-07 | Forsight Vision4, Inc. | Implantable therapeutic device |
WO2010088548A1 (en) | 2009-01-29 | 2010-08-05 | Forsight Labs, Llc | Posterior segment drug delivery |
WO2010096458A1 (en) * | 2009-02-18 | 2010-08-26 | Cormatrix Cardiovascular, Inc. | Compositions and methods for preventing cardiac arrhythmia |
US8267992B2 (en) | 2009-03-02 | 2012-09-18 | Boston Scientific Scimed, Inc. | Self-buffering medical implants |
US8691983B2 (en) * | 2009-03-03 | 2014-04-08 | Innovative Surface Technologies, Inc. | Brush polymer coating by in situ polymerization from photoreactive surface |
US8071156B2 (en) | 2009-03-04 | 2011-12-06 | Boston Scientific Scimed, Inc. | Endoprostheses |
EP2410954A4 (en) * | 2009-03-23 | 2014-03-05 | Micell Technologies Inc | PERIPHERAL STENTS WITH LAYERS |
US20100249783A1 (en) * | 2009-03-24 | 2010-09-30 | Warsaw Orthopedic, Inc. | Drug-eluting implant cover |
US20100247600A1 (en) * | 2009-03-24 | 2010-09-30 | Warsaw Orthopedic, Inc. | Therapeutic drug eluting implant cover and method of making the same |
JP2012522589A (ja) * | 2009-04-01 | 2012-09-27 | ミシェル テクノロジーズ,インコーポレイテッド | 被覆ステント |
US8609127B2 (en) * | 2009-04-03 | 2013-12-17 | Warsaw Orthopedic, Inc. | Medical implant with bioactive material and method of making the medical implant |
US9078712B2 (en) * | 2009-04-15 | 2015-07-14 | Warsaw Orthopedic, Inc. | Preformed drug-eluting device to be affixed to an anterior spinal plate |
US9414864B2 (en) * | 2009-04-15 | 2016-08-16 | Warsaw Orthopedic, Inc. | Anterior spinal plate with preformed drug-eluting device affixed thereto |
EP3366326A1 (en) | 2009-04-17 | 2018-08-29 | Micell Technologies, Inc. | Stents having controlled elution |
US8399443B2 (en) | 2009-04-22 | 2013-03-19 | Mercator Medsystems, Inc. | Treatment of hypertension by renal vascular delivery of guanethidine |
EP2421571A2 (en) * | 2009-04-24 | 2012-02-29 | Boston Scientific Scimed, Inc. | Use of drug polymorphs to achieve controlled drug delivery from a coated medical device |
US8287937B2 (en) | 2009-04-24 | 2012-10-16 | Boston Scientific Scimed, Inc. | Endoprosthese |
US20100285085A1 (en) * | 2009-05-07 | 2010-11-11 | Abbott Cardiovascular Systems Inc. | Balloon coating with drug transfer control via coating thickness |
WO2010148378A1 (en) | 2009-06-19 | 2010-12-23 | Medtronic, Inc. | Lead having polymeric layer disposed over electrode |
WO2010151269A1 (en) | 2009-06-26 | 2010-12-29 | Biotic Laboratories, Inc. | Para-xylylene based multilayer drug elution devices |
EP2451496B1 (en) | 2009-07-10 | 2015-07-22 | Boston Scientific Scimed, Inc. | Use of nanocrystals for a drug delivery balloon |
EP2453834A4 (en) | 2009-07-16 | 2014-04-16 | Micell Technologies Inc | MEDICAL DEVICE DISPENSING MEDICINE |
EP2962707B1 (en) | 2009-07-17 | 2019-07-24 | Boston Scientific Scimed, Inc. | Drug delivery balloons with improved crystal size and density |
US8361591B2 (en) * | 2009-08-12 | 2013-01-29 | Medos International Sarl | Packaging with active protection layer |
US8313811B2 (en) * | 2009-08-12 | 2012-11-20 | Medos International S.A.R.L. | Plasma enhanced polymer ultra-thin multi-layer packaging |
US8313819B2 (en) | 2009-08-12 | 2012-11-20 | Medos International S.A.R.L. | Ultra-thin multi-layer packaging |
CN102665606A (zh) * | 2009-09-24 | 2012-09-12 | 微排放器公司 | 用于生物医学用途的可注射水凝胶线丝 |
US9993252B2 (en) * | 2009-10-26 | 2018-06-12 | Microvention, Inc. | Embolization device constructed from expansile polymer |
US8795727B2 (en) | 2009-11-09 | 2014-08-05 | Spotlight Technology Partners Llc | Fragmented hydrogels |
US9221075B2 (en) * | 2009-11-09 | 2015-12-29 | Ethicon, Inc. | Surgical needle coatings and methods |
US9332982B2 (en) * | 2009-11-09 | 2016-05-10 | Ethicon, Llc | Surgical needle coatings and methods |
US9700650B2 (en) | 2009-11-09 | 2017-07-11 | Spotlight Technology Partners Llc | Polysaccharide based hydrogels |
US9320890B2 (en) * | 2009-11-09 | 2016-04-26 | W. L. Gore & Associates, Inc. | Drug eluting composite |
US9259219B2 (en) | 2009-11-09 | 2016-02-16 | Ethicon, Llc | Surgical needle coatings and methods |
US8894658B2 (en) | 2009-11-10 | 2014-11-25 | Carefusion 2200, Inc. | Apparatus and method for stylet-guided vertebral augmentation |
CN104941004B (zh) | 2009-11-25 | 2018-09-14 | 扩散技术公司 | 用抗微生物金属离子对掺杂沸石的塑料的后加载方法 |
PT2506857T (pt) | 2009-12-01 | 2018-05-14 | Translate Bio Inc | Entrega de arnm para o acréscimo de proteínas e enzimas em doenças genéticas humanas |
CN102834122B (zh) | 2009-12-11 | 2015-03-11 | 扩散技术公司 | 制备聚醚醚酮抗微生物植入物的方法 |
US20130006382A1 (en) * | 2009-12-18 | 2013-01-03 | Vysera Biomedical Limited | Gastrointestinal implant device |
AU2010331820B2 (en) * | 2009-12-18 | 2015-03-05 | Vysera Biomedical Limited | A urological device |
US8660628B2 (en) * | 2009-12-21 | 2014-02-25 | Medtronic Minimed, Inc. | Analyte sensors comprising blended membrane compositions and methods for making and using them |
US8361140B2 (en) * | 2009-12-29 | 2013-01-29 | Boston Scientific Scimed, Inc. | High strength low opening pressure stent design |
CN102125474B (zh) * | 2010-01-19 | 2012-10-31 | 微创医疗器械(上海)有限公司 | 一种在医疗器械上装载药物和/或聚合物的方法和装置 |
US8568471B2 (en) | 2010-01-30 | 2013-10-29 | Abbott Cardiovascular Systems Inc. | Crush recoverable polymer scaffolds |
US8808353B2 (en) | 2010-01-30 | 2014-08-19 | Abbott Cardiovascular Systems Inc. | Crush recoverable polymer scaffolds having a low crossing profile |
EP2531140B1 (en) * | 2010-02-02 | 2017-11-01 | Micell Technologies, Inc. | Stent and stent delivery system with improved deliverability |
US8398916B2 (en) | 2010-03-04 | 2013-03-19 | Icon Medical Corp. | Method for forming a tubular medical device |
WO2011119573A1 (en) | 2010-03-23 | 2011-09-29 | Boston Scientific Scimed, Inc. | Surface treated bioerodible metal endoprostheses |
CA2794080A1 (en) | 2010-03-24 | 2011-09-29 | Advanced Bifurcation Systems, Inc. | System and methods for treating a bifurcation |
WO2011119883A1 (en) | 2010-03-24 | 2011-09-29 | Advanced Bifurcation Systems, Inc. | Stent alignment during treatment of a bifurcation |
EP3616655B1 (en) | 2010-03-24 | 2023-08-30 | Advanced Bifurcation Systems Inc. | Selective stent crimping |
DE202011111004U1 (de) | 2010-03-24 | 2018-04-17 | Advanced Bifurcation Systems, Inc. | Systeme für das ostiale Stenting einer Bifurkation |
US8795762B2 (en) * | 2010-03-26 | 2014-08-05 | Battelle Memorial Institute | System and method for enhanced electrostatic deposition and surface coatings |
MX2012011155A (es) | 2010-03-29 | 2012-12-05 | Abraxis Bioscience Llc | Metodos para mejorar suministros de farmacos y efectividad de agentes terapeuticos. |
HUE030207T2 (en) | 2010-03-29 | 2017-04-28 | Abraxis Bioscience Llc | Cancer Treatment Procedures |
US8685433B2 (en) | 2010-03-31 | 2014-04-01 | Abbott Cardiovascular Systems Inc. | Absorbable coating for implantable device |
EP2560576B1 (en) | 2010-04-22 | 2018-07-18 | Micell Technologies, Inc. | Stents and other devices having extracellular matrix coating |
CA2795836C (en) | 2010-05-07 | 2015-11-17 | Difusion Technologies, Inc. | Medical implant comprising a thermoplastic resin having aluminosilicate particles incorporated therein |
US8696738B2 (en) | 2010-05-20 | 2014-04-15 | Maquet Cardiovascular Llc | Composite prosthesis with external polymeric support structure and methods of manufacturing the same |
AU2011261685B2 (en) | 2010-06-04 | 2016-02-11 | Abraxis Bioscience, Llc | Methods of treatment of pancreatic cancer |
US9220506B2 (en) | 2010-06-16 | 2015-12-29 | DePuy Synthes Products, Inc. | Occlusive device with stretch resistant member and anchor filament |
US8389041B2 (en) | 2010-06-17 | 2013-03-05 | Abbott Cardiovascular Systems, Inc. | Systems and methods for rotating and coating an implantable device |
PL217879B1 (pl) | 2010-07-06 | 2014-08-29 | Univ Jagielloński | Wielowarstwowa powłoka ochronna do zabezpieczania powierzchni metalowych materiałów implantacyjnych i jej zastosowanie |
WO2012009684A2 (en) | 2010-07-16 | 2012-01-19 | Micell Technologies, Inc. | Drug delivery medical device |
CN105435338B (zh) | 2010-08-05 | 2019-03-26 | 弗赛特影像4股份有限公司 | 用于药物输送的注入器装置和方法 |
PL2600812T3 (pl) | 2010-08-05 | 2022-01-24 | Forsight Vision4, Inc. | Urządzenie do leczenia oczu |
US9193827B2 (en) | 2010-08-26 | 2015-11-24 | Massachusetts Institute Of Technology | Poly(beta-amino alcohols), their preparation, and uses thereof |
EP2611476B1 (en) | 2010-09-02 | 2016-08-10 | Boston Scientific Scimed, Inc. | Coating process for drug delivery balloons using heat-induced rewrap memory |
US8992410B2 (en) | 2010-11-03 | 2015-03-31 | Vysera Biomedical Limited | Urological device |
US9861814B2 (en) | 2010-12-23 | 2018-01-09 | Medtronic, Inc. | Medical electrical lead having biological surface and methods of making and using same |
EP3449879B1 (en) | 2011-02-08 | 2020-09-23 | Advanced Bifurcation Systems Inc. | System for treating a bifurcation with a fully crimped stent |
WO2012109382A2 (en) | 2011-02-08 | 2012-08-16 | Advanced Bifurcation Systems, Inc. | Multi-stent and multi-balloon apparatus for treating bifurcations and methods of use |
US9415193B2 (en) | 2011-03-04 | 2016-08-16 | W. L. Gore & Associates, Inc. | Eluting medical devices |
US9238716B2 (en) | 2011-03-28 | 2016-01-19 | Massachusetts Institute Of Technology | Conjugated lipomers and uses thereof |
KR101240293B1 (ko) * | 2011-03-31 | 2013-03-07 | 전용복 | 옻이 적용된 스텐트 및 그 제조방법 |
WO2012142318A1 (en) * | 2011-04-14 | 2012-10-18 | The Regents Of The University Of California | Multilayer thin film drug delivery device and methods of making and using the same |
WO2012145431A2 (en) | 2011-04-18 | 2012-10-26 | Microvention, Inc. | Embolic devices |
WO2012155093A1 (en) | 2011-05-11 | 2012-11-15 | Microvention, Inc. | Device for occluding a lumen |
SG194880A1 (en) | 2011-05-27 | 2013-12-30 | Cormatrix Cardiovascular Inc | Sterilized, acellular extracellular matrix compositions and methods ofmaking thereof |
WO2012166819A1 (en) | 2011-05-31 | 2012-12-06 | Micell Technologies, Inc. | System and process for formation of a time-released, drug-eluting transferable coating |
SI2717893T1 (sl) | 2011-06-08 | 2019-10-30 | Translate Bio Inc | Sestavki lipidnih nanodelcev in postopki za dostavo mRNA |
CN102824236B (zh) * | 2011-06-16 | 2016-01-20 | 乐普(北京)医疗器械股份有限公司 | 一种生物可吸收聚合物支架基体及其制备方法和应用 |
WO2013012689A1 (en) | 2011-07-15 | 2013-01-24 | Micell Technologies, Inc. | Drug delivery medical device |
US8726483B2 (en) | 2011-07-29 | 2014-05-20 | Abbott Cardiovascular Systems Inc. | Methods for uniform crimping and deployment of a polymer scaffold |
US8669360B2 (en) | 2011-08-05 | 2014-03-11 | Boston Scientific Scimed, Inc. | Methods of converting amorphous drug substance into crystalline form |
US9056152B2 (en) | 2011-08-25 | 2015-06-16 | Boston Scientific Scimed, Inc. | Medical device with crystalline drug coating |
US10188772B2 (en) | 2011-10-18 | 2019-01-29 | Micell Technologies, Inc. | Drug delivery medical device |
AU2012325801B2 (en) | 2011-10-19 | 2016-05-12 | Mercator Medsystems, Inc. | Localized modulation of tissues and cells to enhance therapeutic effects including renal denervation |
US10195066B2 (en) | 2011-12-19 | 2019-02-05 | Coloplast A/S | Luminal prosthesis and implant device |
US10010448B2 (en) | 2012-02-03 | 2018-07-03 | Forsight Vision4, Inc. | Insertion and removal methods and apparatus for therapeutic devices |
US10940167B2 (en) | 2012-02-10 | 2021-03-09 | Cvdevices, Llc | Methods and uses of biological tissues for various stent and other medical applications |
US9220759B2 (en) | 2012-02-23 | 2015-12-29 | Abbott Cardiovascular Systems Inc. | Treatment of diabetic patients with a drug eluting stent and adjunctive therapy |
US9220584B2 (en) | 2012-03-30 | 2015-12-29 | Abbott Cardiovascular Systems Inc. | Treatment of diabetic patients with a stent and locally administered adjunctive therapy |
US8992595B2 (en) | 2012-04-04 | 2015-03-31 | Trivascular, Inc. | Durable stent graft with tapered struts and stable delivery methods and devices |
US9498363B2 (en) | 2012-04-06 | 2016-11-22 | Trivascular, Inc. | Delivery catheter for endovascular device |
US8998977B2 (en) | 2012-04-13 | 2015-04-07 | Medtronic Vascular, Inc. | Hollow drug-filled stent and method of forming hollow drug-filled stent |
WO2013158781A1 (en) | 2012-04-18 | 2013-10-24 | Microvention, Inc. | Embolic devices |
US9308355B2 (en) | 2012-06-01 | 2016-04-12 | Surmodies, Inc. | Apparatus and methods for coating medical devices |
US9827401B2 (en) | 2012-06-01 | 2017-11-28 | Surmodics, Inc. | Apparatus and methods for coating medical devices |
EP3536787A1 (en) | 2012-06-08 | 2019-09-11 | Translate Bio, Inc. | Nuclease resistant polynucleotides and uses thereof |
US9956385B2 (en) | 2012-06-28 | 2018-05-01 | The Spectranetics Corporation | Post-processing of a medical device to control morphology and mechanical properties |
EP2875056B1 (en) | 2012-07-17 | 2020-05-13 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Nitric oxide-releasing diazeniumdiolated polyvinylpyrrolidone-based polymers, and compositions, medical devices, and uses thereof |
US10173038B2 (en) | 2012-09-05 | 2019-01-08 | W. L. Gore & Associates, Inc. | Retractable sheath devices, systems, and methods |
US11090468B2 (en) | 2012-10-25 | 2021-08-17 | Surmodics, Inc. | Apparatus and methods for coating medical devices |
AU2014214700B2 (en) | 2013-02-11 | 2018-01-18 | Cook Medical Technologies Llc | Expandable support frame and medical device |
EP2967803B1 (en) | 2013-03-12 | 2023-12-27 | Micell Technologies, Inc. | Bioabsorbable biomedical implants |
US10130288B2 (en) | 2013-03-14 | 2018-11-20 | Cell and Molecular Tissue Engineering, LLC | Coated sensors, and corresponding systems and methods |
US10405961B2 (en) | 2013-03-14 | 2019-09-10 | Cell and Molecular Tissue Engineering, LLC | Coated surgical mesh, and corresponding systems and methods |
KR102311614B1 (ko) | 2013-03-14 | 2021-10-08 | 샤이어 휴먼 지네틱 테라피즈 인크. | Cftr mrna 조성물 및 관련 방법 및 사용 |
AU2014236396A1 (en) | 2013-03-14 | 2015-08-13 | Shire Human Genetic Therapies, Inc. | Methods for purification of messenger RNA |
US9320592B2 (en) | 2013-03-15 | 2016-04-26 | Covidien Lp | Coated medical devices and methods of making and using same |
US11065368B2 (en) | 2013-03-15 | 2021-07-20 | Cook Biotech Incorporated | Drug eluting graft constructs and methods |
US9545301B2 (en) | 2013-03-15 | 2017-01-17 | Covidien Lp | Coated medical devices and methods of making and using same |
CN105246438B (zh) | 2013-03-28 | 2018-01-26 | 弗赛特影像4股份有限公司 | 用于输送治疗物质的眼科植入物 |
US9315472B2 (en) | 2013-05-01 | 2016-04-19 | Massachusetts Institute Of Technology | 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof |
KR102079613B1 (ko) | 2013-05-15 | 2020-02-20 | 미셀 테크놀로지즈, 인코포레이티드 | 생흡수성 생체의학적 임플란트 |
CA2919504A1 (en) | 2013-08-01 | 2015-02-05 | Christine BRONIKOWSKI | Tissue adjustment implant |
USD715442S1 (en) | 2013-09-24 | 2014-10-14 | C. R. Bard, Inc. | Tissue marker for intracorporeal site identification |
USD715942S1 (en) | 2013-09-24 | 2014-10-21 | C. R. Bard, Inc. | Tissue marker for intracorporeal site identification |
USD716450S1 (en) | 2013-09-24 | 2014-10-28 | C. R. Bard, Inc. | Tissue marker for intracorporeal site identification |
USD716451S1 (en) | 2013-09-24 | 2014-10-28 | C. R. Bard, Inc. | Tissue marker for intracorporeal site identification |
CN105658242A (zh) | 2013-10-22 | 2016-06-08 | 夏尔人类遗传性治疗公司 | 用于苯丙酮尿症的mrna疗法 |
AU2014340092B2 (en) | 2013-10-22 | 2019-09-19 | Translate Bio, Inc. | mRNA therapy for Argininosuccinate Synthetase Deficiency |
CA2928078A1 (en) | 2013-10-22 | 2015-04-30 | Shire Human Genetic Therapies, Inc. | Lipid formulations for delivery of messenger rna |
US9668890B2 (en) | 2013-11-22 | 2017-06-06 | Covidien Lp | Anti-thrombogenic medical devices and methods |
US10525171B2 (en) | 2014-01-24 | 2020-01-07 | The Spectranetics Corporation | Coatings for medical devices |
US10124090B2 (en) | 2014-04-03 | 2018-11-13 | Terumo Corporation | Embolic devices |
CN110511927A (zh) | 2014-04-25 | 2019-11-29 | 川斯勒佰尔公司 | 信使rna的纯化方法 |
US10092663B2 (en) | 2014-04-29 | 2018-10-09 | Terumo Corporation | Polymers |
WO2015167752A1 (en) | 2014-04-29 | 2015-11-05 | Microvention, Inc. | Polymers including active agents |
US9765171B2 (en) | 2014-05-30 | 2017-09-19 | Pall Corporation | Self-assembling polymers—V |
US9469733B2 (en) | 2014-05-30 | 2016-10-18 | Pall Corporation | Self-assembled structure and membrane comprising block copolymer and process for producing the same by spin coating (IVa) |
US9441078B2 (en) | 2014-05-30 | 2016-09-13 | Pall Corporation | Self-assembling polymers—I |
US9593218B2 (en) | 2014-05-30 | 2017-03-14 | Pall Corporation | Self-assembled structure and membrane comprising block copolymer and process for producing the same by spin coating (IIIa) |
US9598543B2 (en) | 2014-05-30 | 2017-03-21 | Pall Corporation | Self-assembled structure and membrane comprising block copolymer and process for producing the same by spin coating (VIa) |
US9593217B2 (en) | 2014-05-30 | 2017-03-14 | Pall Corporation | Self-assembled structure and membrane comprising block copolymer and process for producing the same by spin coating (Va) |
JP6557722B2 (ja) | 2014-05-30 | 2019-08-07 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | 核酸の送達のための生分解性脂質 |
US9592476B2 (en) | 2014-05-30 | 2017-03-14 | Pall Corporation | Membrane comprising self-assembled block copolymer and process for producing the same by hybrid casting (IIb) |
US9592477B2 (en) | 2014-05-30 | 2017-03-14 | Pall Corporation | Membrane comprising self-assembled block copolymer and process for producing the same by hybrid casting (Ib) |
US9593219B2 (en) | 2014-05-30 | 2017-03-14 | Pall Corporation | Membrane comprising self-assembled block copolymer and process for producing the same by spin coating (IIa) |
CN111588695A (zh) | 2014-06-24 | 2020-08-28 | 川斯勒佰尔公司 | 用于递送核酸的立体化学富集组合物 |
WO2015199816A1 (en) | 2014-06-24 | 2015-12-30 | Icon Medical Corp. | Improved metal alloys for medical devices |
US9840479B2 (en) | 2014-07-02 | 2017-12-12 | Massachusetts Institute Of Technology | Polyamine-fatty acid derived lipidoids and uses thereof |
MY182497A (en) | 2014-07-15 | 2021-01-25 | Forsight Vision4 Inc | Ocular implant delivery device and method |
WO2016033424A1 (en) | 2014-08-29 | 2016-03-03 | Genzyme Corporation | Methods for the prevention and treatment of major adverse cardiovascular events using compounds that modulate apolipoprotein b |
US9789228B2 (en) | 2014-12-11 | 2017-10-17 | Covidien Lp | Antimicrobial coatings for medical devices and processes for preparing such coatings |
US9956323B2 (en) | 2014-12-18 | 2018-05-01 | Cook Medical Technologies Llc | Medical devices for local bioactive delivery |
WO2016122009A1 (ko) * | 2015-01-26 | 2016-08-04 | (주)메타바이오메드 | 폴리락트산계 봉합사 앵커 및 이의 제조방법 |
US9999527B2 (en) | 2015-02-11 | 2018-06-19 | Abbott Cardiovascular Systems Inc. | Scaffolds having radiopaque markers |
EP3307388B1 (en) | 2015-06-10 | 2022-06-22 | Ekos Corporation | Ultrasound catheter |
WO2016201250A1 (en) | 2015-06-11 | 2016-12-15 | Microvention, Inc. | Expansile device for implantation |
US9700443B2 (en) | 2015-06-12 | 2017-07-11 | Abbott Cardiovascular Systems Inc. | Methods for attaching a radiopaque marker to a scaffold |
EP3127561A1 (en) | 2015-08-05 | 2017-02-08 | Jenpolymer Materials UG & Co. KG | Medical implant based on nanocellulose |
KR20180084104A (ko) | 2015-11-20 | 2018-07-24 | 포사이트 비젼4, 인크. | 연장 방출 약물 전달 장치를 위한 다공성 구조물 |
US11766506B2 (en) | 2016-03-04 | 2023-09-26 | Mirus Llc | Stent device for spinal fusion |
JP7009384B2 (ja) | 2016-04-05 | 2022-01-25 | フォーサイト・ビジョン フォー・インコーポレーテッド | 移植可能な眼薬送達デバイス |
KR101791337B1 (ko) | 2016-04-20 | 2017-10-31 | 서울대학교산학협력단 | 선택적 플라즈마 에칭법으로 형성된 방사선불투과성 중금속 코팅층을 포함하는 니티놀 기반 스텐트의 제조방법 |
WO2018107123A1 (en) | 2016-12-09 | 2018-06-14 | Zenflow, Inc. | Systems, devices, and methods for the accurate deployment of an implant in the prostatic urethra |
MA47603A (fr) | 2017-02-27 | 2020-01-01 | Translate Bio Inc | Nouvel arnm cftr à codons optimisés |
WO2018158311A1 (en) | 2017-02-28 | 2018-09-07 | University College Cork - National University Of Ireland, Cork | An intravascular cell therapy device |
KR101875587B1 (ko) * | 2017-03-06 | 2018-07-09 | 한남대학교 산학협력단 | 기관 재생 유도관 및 이의 제조방법 |
KR101865671B1 (ko) * | 2017-03-06 | 2018-06-11 | 한남대학교 산학협력단 | 약물을 포함하는 기관 재생 유도관 및 이의 제조방법 |
IL270631B2 (en) | 2017-05-16 | 2024-03-01 | Translate Bio Inc | Treatment of cystic fibrosis through the administration of mRNA with an optimal codon encoding ctfr |
US11648135B2 (en) | 2017-09-13 | 2023-05-16 | Boston Scientific Scimed, Inc. | Coated stent |
US11197666B2 (en) | 2017-09-15 | 2021-12-14 | Cilag Gmbh International | Surgical coated needles |
US20190120785A1 (en) | 2017-10-24 | 2019-04-25 | Dexcom, Inc. | Pre-connected analyte sensors |
US11331022B2 (en) | 2017-10-24 | 2022-05-17 | Dexcom, Inc. | Pre-connected analyte sensors |
DE102018110591B4 (de) * | 2018-05-03 | 2022-11-03 | Acandis Gmbh | Medizinische Vorrichtung mit Fibrinbeschichtung, System und Set mit einer derartigen Vorrichtung sowie Herstellverfahren |
CN112930396A (zh) | 2018-08-24 | 2021-06-08 | 川斯勒佰尔公司 | 用于纯化信使rna的方法 |
WO2020112816A1 (en) | 2018-11-29 | 2020-06-04 | Surmodics, Inc. | Apparatus and methods for coating medical devices |
US11819590B2 (en) | 2019-05-13 | 2023-11-21 | Surmodics, Inc. | Apparatus and methods for coating medical devices |
EP3970762A4 (en) * | 2019-05-15 | 2022-12-14 | Seoul National University R&DB Foundation | PROCESS FOR THE MANUFACTURE OF ARTIFICIAL EPTFE BLOOD VESSELS WITH IMPROVED HEMOCOMPATIBILITY BY SELECTIVE PLASMA ETCHING |
DE102019121562B4 (de) * | 2019-08-09 | 2024-01-11 | Acandis Gmbh | Medizinische Vorrichtung zur Behandlung von Aneurysmen |
US11890213B2 (en) | 2019-11-19 | 2024-02-06 | Zenflow, Inc. | Systems, devices, and methods for the accurate deployment and imaging of an implant in the prostatic urethra |
CL2021003572A1 (es) * | 2021-12-30 | 2022-04-22 | Material de silicona funcionalizada con nanopartículas de cobre que reduce la carga bacteriana y la formación de biopelícula | |
CN114984330A (zh) * | 2022-06-07 | 2022-09-02 | 新乡医学院 | 一种兼具抗凝与抗钙化的脱细胞血管支架及其制备方法 |
CN116570768B (zh) * | 2023-03-10 | 2024-02-02 | 浙江大学 | 一种多层力学仿生缓释抗菌气管补片及其制备方法 |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3699956A (en) * | 1970-10-01 | 1972-10-24 | Tecna Corp | Percutaneous lead device |
US4101984A (en) * | 1975-05-09 | 1978-07-25 | Macgregor David C | Cardiovascular prosthetic devices and implants with porous systems |
US4343788A (en) * | 1979-06-29 | 1982-08-10 | The Procter & Gamble Company | Antimicrobial polymer compositions |
US4479795A (en) * | 1979-06-29 | 1984-10-30 | The Procter & Gamble Company | Antimicrobial polymer compositions |
US4769013A (en) * | 1982-09-13 | 1988-09-06 | Hydromer, Inc. | Bio-effecting medical material and device |
US5108424A (en) * | 1984-01-30 | 1992-04-28 | Meadox Medicals, Inc. | Collagen-impregnated dacron graft |
US5197977A (en) * | 1984-01-30 | 1993-03-30 | Meadox Medicals, Inc. | Drug delivery collagen-impregnated synthetic vascular graft |
WO1986007541A1 (en) * | 1985-06-19 | 1986-12-31 | Yasushi Zyo | Composition which can impart antithrombotic ability and medical apparatus to be in contact with blood |
WO1989011500A1 (en) * | 1988-05-17 | 1989-11-30 | Commonwealth Scientific And Industrial Research Or | Hydrophilic non-swelling multilayer polymeric materials and process for their manufacture |
US5053048A (en) * | 1988-09-22 | 1991-10-01 | Cordis Corporation | Thromboresistant coating |
US5298255A (en) * | 1988-10-28 | 1994-03-29 | Terumo Kabushiki Kaisha | Antithrombic medical material, artificial internal organ, and method for production of antithrombic medical material |
US5067491A (en) * | 1989-12-08 | 1991-11-26 | Becton, Dickinson And Company | Barrier coating on blood contacting devices |
US5059166A (en) * | 1989-12-11 | 1991-10-22 | Medical Innovative Technologies R & D Limited Partnership | Intra-arterial stent with the capability to inhibit intimal hyperplasia |
US5304121A (en) * | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
WO1991017724A1 (en) * | 1990-05-17 | 1991-11-28 | Harbor Medical Devices, Inc. | Medical device polymer |
US5112457A (en) * | 1990-07-23 | 1992-05-12 | Case Western Reserve University | Process for producing hydroxylated plasma-polymerized films and the use of the films for enhancing the compatiblity of biomedical implants |
US5455040A (en) * | 1990-07-26 | 1995-10-03 | Case Western Reserve University | Anticoagulant plasma polymer-modified substrate |
US5244654A (en) * | 1990-11-08 | 1993-09-14 | Cordis Corporation | Radiofrequency plasma biocompatibility treatment of inside surfaces of medical tubing and the like |
US5102402A (en) * | 1991-01-04 | 1992-04-07 | Medtronic, Inc. | Releasable coatings on balloon catheters |
US5344411A (en) * | 1991-02-27 | 1994-09-06 | Leonard Bloom | Method and device for inhibiting HIV, hepatitis B and other viruses and germs when using a catheter in a medical environment |
NL9101159A (nl) * | 1991-07-03 | 1993-02-01 | Industrial Res Bv | Vormvast te maken uitzetbare ring, cylinder of huls. |
US5356433A (en) * | 1991-08-13 | 1994-10-18 | Cordis Corporation | Biocompatible metal surfaces |
SE9102778D0 (sv) * | 1991-09-25 | 1991-09-25 | Siemens Elema Ab | Implanterbar medicinsk anordning |
JP3093375B2 (ja) * | 1991-11-01 | 2000-10-03 | 株式会社東海メディカルプロダクツ | 抗血栓性物質の固定化方法 |
US5270047A (en) * | 1991-11-21 | 1993-12-14 | Kauffman Raymond F | Local delivery of dipyridamole for the treatment of proliferative diseases |
US5217493A (en) * | 1992-03-11 | 1993-06-08 | Board Of Regents, The University Of Texas System | Antibacterial coated medical implants |
US5282823A (en) * | 1992-03-19 | 1994-02-01 | Medtronic, Inc. | Intravascular radially expandable stent |
US5383927A (en) * | 1992-05-07 | 1995-01-24 | Intervascular Inc. | Non-thromogenic vascular prosthesis |
US5681575A (en) * | 1992-05-19 | 1997-10-28 | Westaim Technologies Inc. | Anti-microbial coating for medical devices |
US5383928A (en) * | 1992-06-10 | 1995-01-24 | Emory University | Stent sheath for local drug delivery |
US5449382A (en) * | 1992-11-04 | 1995-09-12 | Dayton; Michael P. | Minimally invasive bioactivated endoprosthesis for vessel repair |
US5342348A (en) * | 1992-12-04 | 1994-08-30 | Kaplan Aaron V | Method and device for treating and enlarging body lumens |
US5443458A (en) * | 1992-12-22 | 1995-08-22 | Advanced Cardiovascular Systems, Inc. | Multilayered biodegradable stent and method of manufacture |
US5419760A (en) * | 1993-01-08 | 1995-05-30 | Pdt Systems, Inc. | Medicament dispensing stent for prevention of restenosis of a blood vessel |
EP0689465A1 (en) * | 1993-03-18 | 1996-01-03 | Cedars-Sinai Medical Center | Drug incorporating and releasing polymeric coating for bioprosthesis |
US5464650A (en) * | 1993-04-26 | 1995-11-07 | Medtronic, Inc. | Intravascular stent and method |
US5380299A (en) * | 1993-08-30 | 1995-01-10 | Med Institute, Inc. | Thrombolytic treated intravascular medical device |
US5457113A (en) * | 1993-10-15 | 1995-10-10 | Eli Lilly And Company | Methods for inhibiting vascular smooth muscle cell proliferation and restinosis |
KR101307055B1 (ko) * | 2011-03-23 | 2013-09-11 | 율촌화학 주식회사 | 화면 보호 필름 |
-
1995
- 1995-06-07 US US08/484,532 patent/US5609629A/en not_active Expired - Lifetime
-
1996
- 1996-05-16 US US08/645,646 patent/US6096070A/en not_active Expired - Lifetime
- 1996-06-04 ES ES96304018T patent/ES2184838T3/es not_active Expired - Lifetime
- 1996-06-04 DE DE69623855T patent/DE69623855T2/de not_active Expired - Lifetime
- 1996-06-04 EP EP96304018A patent/EP0747069B1/en not_active Expired - Lifetime
- 1996-06-04 DK DK96304018T patent/DK0747069T3/da active
- 1996-06-07 KR KR1019960020190A patent/KR100478074B1/ko not_active IP Right Cessation
- 1996-06-07 JP JP16821896A patent/JP4684375B2/ja not_active Expired - Lifetime
-
2007
- 2007-11-01 JP JP2007284885A patent/JP5090130B2/ja not_active Expired - Lifetime
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100356643B1 (ko) * | 2000-03-31 | 2002-10-18 | 한국과학기술연구원 | 생리활성 물질이 결합된 생체적합성 의료용 금속 재료 및이의 제조 방법 |
KR100491700B1 (ko) * | 2002-03-22 | 2005-05-27 | 주식회사 뉴하트바이오 | 플라즈마 공정을 이용하여 ptfe 표면에 항혈전단백질을 고정화하는 방법 |
Also Published As
Publication number | Publication date |
---|---|
ES2184838T3 (es) | 2003-04-16 |
EP0747069B1 (en) | 2002-09-25 |
US6096070A (en) | 2000-08-01 |
DE69623855T2 (de) | 2003-05-28 |
US5609629A (en) | 1997-03-11 |
EP0747069A2 (en) | 1996-12-11 |
JP2008080143A (ja) | 2008-04-10 |
KR100478074B1 (ko) | 2005-09-15 |
DK0747069T3 (da) | 2002-12-09 |
JP4684375B2 (ja) | 2011-05-18 |
EP0747069A3 (en) | 1998-01-07 |
DE69623855D1 (de) | 2002-10-31 |
JPH0999056A (ja) | 1997-04-15 |
JP5090130B2 (ja) | 2012-12-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR970000275A (ko) | 코팅되고 이식가능한 의료 장치 | |
CA2178541A1 (en) | Implantable medical device | |
US8758428B2 (en) | Coated implantable medical device | |
AU737252B2 (en) | Coated implantable medical device | |
AU771367B2 (en) | Coated implantable medical device | |
US7611532B2 (en) | Coated implantable medical device | |
US8257433B2 (en) | Coated implantable medical device | |
WO1998017331A1 (en) | Silver implantable medical device | |
US7896914B2 (en) | Coated implantable medical device | |
US20150150696A1 (en) | Coated implantable medical device |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 20130227 Year of fee payment: 9 |
|
FPAY | Annual fee payment |
Payment date: 20140227 Year of fee payment: 10 |
|
FPAY | Annual fee payment |
Payment date: 20150227 Year of fee payment: 11 |
|
FPAY | Annual fee payment |
Payment date: 20151230 Year of fee payment: 12 |
|
EXPY | Expiration of term |