JP4921162B2 - 熱ショックタンパク質の阻害剤としてのイソオキサゾール化合物類 - Google Patents

熱ショックタンパク質の阻害剤としてのイソオキサゾール化合物類 Download PDF

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JP4921162B2
JP4921162B2 JP2006502254A JP2006502254A JP4921162B2 JP 4921162 B2 JP4921162 B2 JP 4921162B2 JP 2006502254 A JP2006502254 A JP 2006502254A JP 2006502254 A JP2006502254 A JP 2006502254A JP 4921162 B2 JP4921162 B2 JP 4921162B2
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Japan
Prior art keywords
phenyl
isoxazole
carboxylic acid
dihydroxy
ylmethyl
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Expired - Lifetime
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JP2006502254A
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Japanese (ja)
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JP2006517572A5 (https=
JP2006517572A (ja
Inventor
ドライスデール，マーティン，ジェームス
ディモック，ブライアン，ウィリアム
フィンチ，ハリー
ウェブ，ポール
マクドナルド，エドワード
ジェームス，カレン，エリザベス
チェン，カイ，ミン
マシューズ，トーマス，ピーター
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Vernalis Cambridge Ltd
Cancer Research Technology Ltd
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Vernalis Cambridge Ltd
Cancer Research Technology Ltd
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Priority claimed from GB0303105A external-priority patent/GB0303105D0/en
Priority claimed from GBGB0306560.4A external-priority patent/GB0306560D0/en
Priority claimed from GB0313751A external-priority patent/GB0313751D0/en
Application filed by Vernalis Cambridge Ltd, Cancer Research Technology Ltd filed Critical Vernalis Cambridge Ltd
Publication of JP2006517572A publication Critical patent/JP2006517572A/ja
Publication of JP2006517572A5 publication Critical patent/JP2006517572A5/ja
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
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    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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JP2006502254A 2003-02-11 2004-02-09 熱ショックタンパク質の阻害剤としてのイソオキサゾール化合物類 Expired - Lifetime JP4921162B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB0303105A GB0303105D0 (en) 2003-02-11 2003-02-11 Isoxazole compounds
GB0303105.1 2003-02-11
GBGB0306560.4A GB0306560D0 (en) 2003-03-21 2003-03-21 Isoxazole compounds
GB0306560.4 2003-03-21
GB0313751.0 2003-06-13
GB0313751A GB0313751D0 (en) 2003-06-13 2003-06-13 Isoxazole compounds
PCT/GB2004/000506 WO2004072051A1 (en) 2003-02-11 2004-02-09 Isoxazole compounds as inhibitors of heat shock proteins

Publications (3)

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JP2006517572A JP2006517572A (ja) 2006-07-27
JP2006517572A5 JP2006517572A5 (https=) 2007-05-10
JP4921162B2 true JP4921162B2 (ja) 2012-04-25

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US (6) US7705027B2 (https=)
EP (1) EP1611112B1 (https=)
JP (1) JP4921162B2 (https=)
KR (1) KR101166749B1 (https=)
CN (1) CN1771235B (https=)
AU (1) AU2004210779B2 (https=)
BR (1) BRPI0407403B1 (https=)
CA (1) CA2515726C (https=)
CY (1) CY1113761T1 (https=)
DK (1) DK1611112T3 (https=)
EA (1) EA009919B1 (https=)
ES (1) ES2393483T3 (https=)
MX (1) MXPA05008335A (https=)
NO (1) NO335001B1 (https=)
NZ (1) NZ541479A (https=)
PT (1) PT1611112E (https=)
SI (1) SI1611112T1 (https=)
WO (1) WO2004072051A1 (https=)

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TWI252847B (en) 2001-07-10 2006-04-11 Synta Pharmaceuticals Corp Synthesis of taxol enhancers
TWI330079B (en) 2003-01-15 2010-09-11 Synta Pharmaceuticals Corp Treatment for cancers
EA009919B1 (ru) 2003-02-11 2008-04-28 Вернэлис (Кембридж) Лимитед Соединения изоксазола
GB0315111D0 (en) * 2003-06-27 2003-07-30 Cancer Rec Tech Ltd Substituted 5-membered ring compounds and their use
JPWO2005063222A1 (ja) * 2003-12-26 2007-07-19 協和醗酵工業株式会社 Ｈｓｐ９０ファミリー蛋白質阻害剤
ATE538778T1 (de) 2004-05-28 2012-01-15 Unigen Inc 1-(3-methyl-2,4-dimethoxyphenyl)-3-(2',4'- dihydroxyphenyl)-propan als hochwirksamer tyrosinase-inhibitor
GB0412769D0 (en) 2004-06-08 2004-07-07 Novartis Ag Organic compounds
CN1993318B (zh) 2004-06-23 2012-10-03 Synta医药公司 用于治疗癌症的双（硫代-酰肼酰胺）盐
JP4820758B2 (ja) 2004-09-22 2011-11-24 日本化薬株式会社 新規ブロック共重合体、ミセル調製物及びそれを有効成分とする抗癌剤
JPWO2006051808A1 (ja) 2004-11-09 2008-05-29 協和醗酵工業株式会社 Ｈｓｐ９０ファミリー蛋白質阻害剤
WO2006055760A1 (en) 2004-11-18 2006-05-26 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
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