JP2006517572A5 - - Google Patents
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- Publication number
- JP2006517572A5 JP2006517572A5 JP2006502254A JP2006502254A JP2006517572A5 JP 2006517572 A5 JP2006517572 A5 JP 2006517572A5 JP 2006502254 A JP2006502254 A JP 2006502254A JP 2006502254 A JP2006502254 A JP 2006502254A JP 2006517572 A5 JP2006517572 A5 JP 2006517572A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- isoxazole
- dihydroxy
- carboxylic acid
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- -1 C 1 -C 6 alkyl Chemical group 0.000 claims 57
- 150000001875 compounds Chemical class 0.000 claims 48
- 125000005392 carboxamide group Chemical group NC(=O)* 0.000 claims 16
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 239000001257 hydrogen Substances 0.000 claims 16
- 125000001424 substituent group Chemical group 0.000 claims 14
- 125000000623 heterocyclic group Chemical group 0.000 claims 12
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 10
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- 239000012453 solvate Substances 0.000 claims 10
- 101710113864 Heat shock protein 90 Proteins 0.000 claims 8
- 102100034051 Heat shock protein HSP 90-alpha Human genes 0.000 claims 8
- 125000001246 bromo group Chemical group Br* 0.000 claims 8
- 125000002837 carbocyclic group Chemical group 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 8
- 125000001309 chloro group Chemical group Cl* 0.000 claims 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 8
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 8
- 229910052757 nitrogen Inorganic materials 0.000 claims 8
- 230000000694 effects Effects 0.000 claims 7
- 150000001204 N-oxides Chemical class 0.000 claims 6
- 125000003277 amino group Chemical group 0.000 claims 6
- 230000001419 dependent effect Effects 0.000 claims 6
- 230000002401 inhibitory effect Effects 0.000 claims 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 6
- 125000002757 morpholinyl group Chemical group 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 125000004193 piperazinyl group Chemical group 0.000 claims 6
- 125000003386 piperidinyl group Chemical group 0.000 claims 6
- 239000000651 prodrug Substances 0.000 claims 6
- 229940002612 prodrug Drugs 0.000 claims 6
- 230000003381 solubilizing effect Effects 0.000 claims 6
- 125000004122 cyclic group Chemical group 0.000 claims 5
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 125000006260 ethylaminocarbonyl group Chemical group [H]N(C(*)=O)C([H])([H])C([H])([H])[H] 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 4
- 125000004076 pyridyl group Chemical group 0.000 claims 4
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 4
- 125000003107 substituted aryl group Chemical group 0.000 claims 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 4
- 125000004450 alkenylene group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000006239 protecting group Chemical group 0.000 claims 3
- 125000006727 (C1-C6) alkenyl group Chemical group 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 125000006728 (C1-C6) alkynyl group Chemical group 0.000 claims 2
- ILFIRBGRMCGNOO-UHFFFAOYSA-N 1,1-bis($l^{1}-oxidanyl)ethene Chemical group [O]C([O])=C ILFIRBGRMCGNOO-UHFFFAOYSA-N 0.000 claims 2
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 2
- LURPCKMCPZKVLG-UHFFFAOYSA-N 3-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazole-5-carboxamide Chemical compound CCNC(=O)C=1ON=C(C=2C(=CC(O)=C(Cl)C=2)O)C=1C(C=C1)=CC=C1CN1CCOCC1 LURPCKMCPZKVLG-UHFFFAOYSA-N 0.000 claims 2
- 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 claims 2
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 2
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims 2
- XWAKANMSVGJPQD-UHFFFAOYSA-N 4-[4-(diethylaminomethyl)phenyl]-5-[2,4-dihydroxy-5-(2-methylphenyl)phenyl]-N-ethyl-1,2-oxazole-3-carboxamide Chemical compound CCNC(=O)C1=NOC(C=2C(=CC(O)=C(C=2)C=2C(=CC=CC=2)C)O)=C1C1=CC=C(CN(CC)CC)C=C1 XWAKANMSVGJPQD-UHFFFAOYSA-N 0.000 claims 2
- NSVZNIOGSFQMSQ-UHFFFAOYSA-N 4-[4-(diethylaminomethyl)phenyl]-N-ethyl-5-[5-(4-fluorophenyl)-2,4-dihydroxyphenyl]-1,2-oxazole-3-carboxamide Chemical compound CCNC(=O)C1=NOC(C=2C(=CC(O)=C(C=2)C=2C=CC(F)=CC=2)O)=C1C1=CC=C(CN(CC)CC)C=C1 NSVZNIOGSFQMSQ-UHFFFAOYSA-N 0.000 claims 2
- WNCGSWNZVHEESS-UHFFFAOYSA-N 4-[4-[(cyclohexylamino)methyl]phenyl]-5-(2,4-dihydroxy-5-propan-2-ylphenyl)-N-ethyl-1,2-oxazole-3-carboxamide Chemical compound CCNC(=O)C1=NOC(C=2C(=CC(O)=C(C(C)C)C=2)O)=C1C(C=C1)=CC=C1CNC1CCCCC1 WNCGSWNZVHEESS-UHFFFAOYSA-N 0.000 claims 2
- INSHMVKUWUOWCX-UHFFFAOYSA-N 4-[4-[(tert-butylamino)methyl]phenyl]-5-(2,4-dihydroxy-5-propan-2-ylphenyl)-N-ethyl-1,2-oxazole-3-carboxamide Chemical compound CCNC(=O)C1=NOC(C=2C(=CC(O)=C(C(C)C)C=2)O)=C1C1=CC=C(CNC(C)(C)C)C=C1 INSHMVKUWUOWCX-UHFFFAOYSA-N 0.000 claims 2
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 2
- OVJLXNJAQKKVCO-UHFFFAOYSA-N 5-(2,4-dihydroxy-5-propan-2-ylphenyl)-4-[4-(morpholin-4-ylmethyl)phenyl]-N-propan-2-yl-1,2-oxazole-3-carboxamide Chemical compound CC(C)NC(=O)C1=NOC(C=2C(=CC(O)=C(C(C)C)C=2)O)=C1C(C=C1)=CC=C1CN1CCOCC1 OVJLXNJAQKKVCO-UHFFFAOYSA-N 0.000 claims 2
- RQRUBPKAYFDPFF-UHFFFAOYSA-N 5-(2,4-dihydroxy-5-propan-2-ylphenyl)-4-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-N-propan-2-yl-1,2-oxazole-3-carboxamide Chemical compound CC(C)NC(=O)C1=NOC(C=2C(=CC(O)=C(C(C)C)C=2)O)=C1C(C=C1)=CC=C1CN1CCN(C)CC1 RQRUBPKAYFDPFF-UHFFFAOYSA-N 0.000 claims 2
- PCXWAYHFMKPLQV-UHFFFAOYSA-N 5-(2,4-dihydroxy-5-propan-2-ylphenyl)-N-ethyl-4-[4-(ethylaminomethyl)phenyl]-1,2-oxazole-3-carboxamide Chemical compound C1=CC(CNCC)=CC=C1C1=C(C=2C(=CC(O)=C(C(C)C)C=2)O)ON=C1C(=O)NCC PCXWAYHFMKPLQV-UHFFFAOYSA-N 0.000 claims 2
- KIPRUYSELCZZTP-UHFFFAOYSA-N 5-(2,4-dihydroxy-5-propan-2-ylphenyl)-N-ethyl-4-[4-[(2-methoxyethylamino)methyl]phenyl]-1,2-oxazole-3-carboxamide Chemical compound CCNC(=O)C1=NOC(C=2C(=CC(O)=C(C(C)C)C=2)O)=C1C1=CC=C(CNCCOC)C=C1 KIPRUYSELCZZTP-UHFFFAOYSA-N 0.000 claims 2
- LRQGHEGCJYDULB-UHFFFAOYSA-N 5-(2,4-dihydroxy-5-propan-2-ylphenyl)-N-ethyl-4-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-1,2-oxazole-3-carboxamide Chemical compound CCNC(=O)C1=NOC(C=2C(=CC(O)=C(C(C)C)C=2)O)=C1C(C=C1)=CC=C1CN1CCN(C)CC1 LRQGHEGCJYDULB-UHFFFAOYSA-N 0.000 claims 2
- FWXKZIWZSRANCX-UHFFFAOYSA-N 5-(2,4-dihydroxy-5-propan-2-ylphenyl)-N-ethyl-4-[4-[(propan-2-ylamino)methyl]phenyl]-1,2-oxazole-3-carboxamide Chemical compound CCNC(=O)C1=NOC(C=2C(=CC(O)=C(C(C)C)C=2)O)=C1C1=CC=C(CNC(C)C)C=C1 FWXKZIWZSRANCX-UHFFFAOYSA-N 0.000 claims 2
- KZJAWYUJSFALRK-UHFFFAOYSA-N 5-(5-chloro-2,4-dihydroxyphenyl)-4-[4-(piperidin-1-ylmethyl)phenyl]-N-propan-2-yl-1,2-oxazole-3-carboxamide Chemical compound CC(C)NC(=O)C1=NOC(C=2C(=CC(O)=C(Cl)C=2)O)=C1C(C=C1)=CC=C1CN1CCCCC1 KZJAWYUJSFALRK-UHFFFAOYSA-N 0.000 claims 2
- APGOABVITLQCKW-UHFFFAOYSA-N 5-(5-chloro-2,4-dihydroxyphenyl)-n-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]isoxazole-3-carboxamide Chemical compound CCNC(=O)C1=NOC(C=2C(=CC(O)=C(Cl)C=2)O)=C1C(C=C1)=CC=C1CN1CCOCC1 APGOABVITLQCKW-UHFFFAOYSA-N 0.000 claims 2
- WDORNDZICKCYOH-UHFFFAOYSA-N 5-(5-tert-butyl-2,4-dihydroxyphenyl)-4-[4-(diethylaminomethyl)phenyl]-N-ethyl-1,2-oxazole-3-carboxamide Chemical compound CCNC(=O)C1=NOC(C=2C(=CC(O)=C(C=2)C(C)(C)C)O)=C1C1=CC=C(CN(CC)CC)C=C1 WDORNDZICKCYOH-UHFFFAOYSA-N 0.000 claims 2
- ZTLWCZRCEYWCOR-UHFFFAOYSA-N 5-(5-tert-butyl-2,4-dihydroxyphenyl)-N-ethyl-4-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-1,2-oxazole-3-carboxamide Chemical compound CCNC(=O)C1=NOC(C=2C(=CC(O)=C(C=2)C(C)(C)C)O)=C1C(C=C1)=CC=C1CN1CCN(C)CC1 ZTLWCZRCEYWCOR-UHFFFAOYSA-N 0.000 claims 2
- IAFDYDGLYZZMSJ-UHFFFAOYSA-N 5-[2,4-dihydroxy-5-(2-methylpropyl)phenyl]-N-ethyl-4-[4-(piperidin-1-ylmethyl)phenyl]-1,2-oxazole-3-carboxamide Chemical compound CCNC(=O)C1=NOC(C=2C(=CC(O)=C(CC(C)C)C=2)O)=C1C(C=C1)=CC=C1CN1CCCCC1 IAFDYDGLYZZMSJ-UHFFFAOYSA-N 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- NAIOWGXKMUYTEJ-UHFFFAOYSA-N N-ethyl-5-(5-ethyl-2,4-dihydroxyphenyl)-4-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-1,2-oxazole-3-carboxamide Chemical compound CCNC(=O)C1=NOC(C=2C(=CC(O)=C(CC)C=2)O)=C1C(C=C1)=CC=C1CN1CCN(C)CC1 NAIOWGXKMUYTEJ-UHFFFAOYSA-N 0.000 claims 2
- KOEWQOUBZIGXIF-UHFFFAOYSA-N N-ethyl-5-[5-(2-fluorophenyl)-2,4-dihydroxyphenyl]-4-[4-(pyrrolidin-1-ylmethyl)phenyl]-1,2-oxazole-3-carboxamide Chemical compound CCNC(=O)C1=NOC(C=2C(=CC(O)=C(C=2)C=2C(=CC=CC=2)F)O)=C1C(C=C1)=CC=C1CN1CCCC1 KOEWQOUBZIGXIF-UHFFFAOYSA-N 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000004419 alkynylene group Chemical group 0.000 claims 2
- 150000001721 carbon Chemical group 0.000 claims 2
- KVALWNOGXNZJNM-UHFFFAOYSA-N chembl252165 Chemical compound CCNC(=O)C1=NOC(C=2C(=CC(O)=C(C(C)C)C=2)O)=C1C1=CC=C(CN(CC)CC)C=C1 KVALWNOGXNZJNM-UHFFFAOYSA-N 0.000 claims 2
- FQKHRMZPORXQSR-UHFFFAOYSA-N chembl252370 Chemical compound CCNC(=O)C1=NOC(C=2C(=CC(O)=C(C(C)C)C=2)O)=C1C(C=C1)=CC=C1CN1CCCCC1 FQKHRMZPORXQSR-UHFFFAOYSA-N 0.000 claims 2
- COBVQNNJVURGON-UHFFFAOYSA-N chembl253185 Chemical compound CCNC(=O)C1=NOC(C=2C(=CC(O)=C(C=2)C(C)(C)C)O)=C1C(C=C1)=CC=C1CN1CCCCC1 COBVQNNJVURGON-UHFFFAOYSA-N 0.000 claims 2
- AEZSTVRHWTURDU-UHFFFAOYSA-N chembl253399 Chemical compound CCNC(=O)C1=NOC(C=2C(=CC(O)=C(Cl)C=2)O)=C1C1=CC=C(CN(CC)CC)C=C1 AEZSTVRHWTURDU-UHFFFAOYSA-N 0.000 claims 2
- NBORIEUQDSFVFQ-UHFFFAOYSA-N chembl253836 Chemical compound CCNC(=O)C1=NOC(C=2C(=CC(O)=C(CCC=3C=CC=CC=3)C=2)O)=C1C(C=C1)=CC=C1CN1CCOCC1 NBORIEUQDSFVFQ-UHFFFAOYSA-N 0.000 claims 2
- LALDVGOZMSLLOR-UHFFFAOYSA-N chembl253837 Chemical compound CCNC(=O)C1=NOC(C=2C(=CC(O)=C(CC)C=2)O)=C1C1=CC=C(CN(CC)CC)C=C1 LALDVGOZMSLLOR-UHFFFAOYSA-N 0.000 claims 2
- IFYJCWYDVYZPLI-UHFFFAOYSA-N chembl254248 Chemical compound CCNC(=O)C1=NOC(C=2C(=CC(O)=C(C=2)C=2C=CC=CC=2)O)=C1C(C=C1)=CC=C1CN1CCOCC1 IFYJCWYDVYZPLI-UHFFFAOYSA-N 0.000 claims 2
- GVNFOZYVKKSCJY-UHFFFAOYSA-N chembl254458 Chemical compound CCNC(=O)C1=NOC(C=2C(=CC(O)=C(CC(C)C)C=2)O)=C1C(C=C1)=CC=C1CN1CCOCC1 GVNFOZYVKKSCJY-UHFFFAOYSA-N 0.000 claims 2
- WLYWTGDTMWWNNG-UHFFFAOYSA-N chembl399583 Chemical compound CCNC(=O)C1=NOC(C=2C(=CC(O)=C(C=2)C(C)(C)C)O)=C1C(C=C1)=CC=C1CN1CCOCC1 WLYWTGDTMWWNNG-UHFFFAOYSA-N 0.000 claims 2
- RNLVKRYMKWCANV-UHFFFAOYSA-N chembl400187 Chemical compound CCNC(=O)C1=NOC(C=2C(=CC(O)=C(CC)C=2)O)=C1C(C=C1)=CC=C1CN1CCOCC1 RNLVKRYMKWCANV-UHFFFAOYSA-N 0.000 claims 2
- YAYJACNPYWHUDS-UHFFFAOYSA-N chembl401370 Chemical compound CCNC(=O)C1=NOC(C=2C(=CC(O)=C(C=2)C=2C=CC=CC=2)O)=C1C1=CC=C(CN(CC)CC)C=C1 YAYJACNPYWHUDS-UHFFFAOYSA-N 0.000 claims 2
- RUXXRSDEOCYOTM-UHFFFAOYSA-N chembl427716 Chemical compound CCNC(=O)C1=NOC(C=2C(=CC(O)=C(Cl)C=2)O)=C1C(C=C1)=CC=C1CN1CCN(C)CC1 RUXXRSDEOCYOTM-UHFFFAOYSA-N 0.000 claims 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 150000004677 hydrates Chemical class 0.000 claims 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 2
- NDAZATDQFDPQBD-UHFFFAOYSA-N luminespib Chemical compound CCNC(=O)C1=NOC(C=2C(=CC(O)=C(C(C)C)C=2)O)=C1C(C=C1)=CC=C1CN1CCOCC1 NDAZATDQFDPQBD-UHFFFAOYSA-N 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- SOWBFZRMHSNYGE-UHFFFAOYSA-N oxamic acid Chemical compound NC(=O)C(O)=O SOWBFZRMHSNYGE-UHFFFAOYSA-N 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000002504 physiological saline solution Substances 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 2
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 101100507655 Canis lupus familiaris HSPA1 gene Proteins 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 208000020406 Creutzfeldt Jacob disease Diseases 0.000 claims 1
- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 206010021143 Hypoxia Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 125000005195 alkyl amino carbonyloxy group Chemical group 0.000 claims 1
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000004696 endometrium Anatomy 0.000 claims 1
- 201000011066 hemangioma Diseases 0.000 claims 1
- 125000004464 hydroxyphenyl group Chemical group 0.000 claims 1
- 230000007954 hypoxia Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 208000008864 scrapie Diseases 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- 0 **c1n[o]c(I)c1* Chemical compound **c1n[o]c(I)c1* 0.000 description 3
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0303105.1 | 2003-02-11 | ||
| GB0303105A GB0303105D0 (en) | 2003-02-11 | 2003-02-11 | Isoxazole compounds |
| GBGB0306560.4A GB0306560D0 (en) | 2003-03-21 | 2003-03-21 | Isoxazole compounds |
| GB0306560.4 | 2003-03-21 | ||
| GB0313751A GB0313751D0 (en) | 2003-06-13 | 2003-06-13 | Isoxazole compounds |
| GB0313751.0 | 2003-06-13 | ||
| PCT/GB2004/000506 WO2004072051A1 (en) | 2003-02-11 | 2004-02-09 | Isoxazole compounds as inhibitors of heat shock proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006517572A JP2006517572A (ja) | 2006-07-27 |
| JP2006517572A5 true JP2006517572A5 (https=) | 2007-05-10 |
| JP4921162B2 JP4921162B2 (ja) | 2012-04-25 |
Family
ID=32872455
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006502254A Expired - Lifetime JP4921162B2 (ja) | 2003-02-11 | 2004-02-09 | 熱ショックタンパク質の阻害剤としてのイソオキサゾール化合物類 |
Country Status (18)
| Country | Link |
|---|---|
| US (6) | US7705027B2 (https=) |
| EP (1) | EP1611112B1 (https=) |
| JP (1) | JP4921162B2 (https=) |
| KR (1) | KR101166749B1 (https=) |
| CN (1) | CN1771235B (https=) |
| AU (1) | AU2004210779B2 (https=) |
| BR (1) | BRPI0407403B1 (https=) |
| CA (1) | CA2515726C (https=) |
| CY (1) | CY1113761T1 (https=) |
| DK (1) | DK1611112T3 (https=) |
| EA (1) | EA009919B1 (https=) |
| ES (1) | ES2393483T3 (https=) |
| MX (1) | MXPA05008335A (https=) |
| NO (1) | NO335001B1 (https=) |
| NZ (1) | NZ541479A (https=) |
| PT (1) | PT1611112E (https=) |
| SI (1) | SI1611112T1 (https=) |
| WO (1) | WO2004072051A1 (https=) |
Families Citing this family (115)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI252847B (en) | 2001-07-10 | 2006-04-11 | Synta Pharmaceuticals Corp | Synthesis of taxol enhancers |
| TWI332943B (en) | 2001-07-10 | 2010-11-11 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
| TWI297335B (en) | 2001-07-10 | 2008-06-01 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
| TWI330079B (en) | 2003-01-15 | 2010-09-11 | Synta Pharmaceuticals Corp | Treatment for cancers |
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- 2004-02-09 PT PT04709273T patent/PT1611112E/pt unknown
- 2004-02-09 AU AU2004210779A patent/AU2004210779B2/en not_active Expired
- 2004-02-09 BR BRPI0407403-3A patent/BRPI0407403B1/pt not_active IP Right Cessation
- 2004-02-09 JP JP2006502254A patent/JP4921162B2/ja not_active Expired - Lifetime
- 2004-02-09 MX MXPA05008335A patent/MXPA05008335A/es active IP Right Grant
-
2005
- 2005-09-09 NO NO20054195A patent/NO335001B1/no unknown
-
2010
- 2010-02-19 US US12/708,686 patent/US8507480B2/en not_active Expired - Fee Related
-
2012
- 2012-06-18 US US13/525,409 patent/US8450310B2/en not_active Expired - Fee Related
- 2012-11-09 CY CY20121101068T patent/CY1113761T1/el unknown
-
2013
- 2013-06-27 US US13/929,098 patent/US9718793B2/en not_active Expired - Fee Related
-
2017
- 2017-06-23 US US15/631,059 patent/US10413550B2/en not_active Expired - Lifetime
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2019
- 2019-07-31 US US16/528,278 patent/US11234987B2/en not_active Expired - Fee Related
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