JP2010508296A5 - - Google Patents

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JP2010508296A5
JP2010508296A5 JP2009534891A JP2009534891A JP2010508296A5 JP 2010508296 A5 JP2010508296 A5 JP 2010508296A5 JP 2009534891 A JP2009534891 A JP 2009534891A JP 2009534891 A JP2009534891 A JP 2009534891A JP 2010508296 A5 JP2010508296 A5 JP 2010508296A5
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Japan
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alkyl
oxazepin
benzamide
hydroxy
hydroxybenzamide
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JP2009534891A
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JP5583406B2 (ja
JP2010508296A (ja
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Priority claimed from PCT/US2007/082668 external-priority patent/WO2008055068A2/en
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JP2009534891A 2006-10-28 2007-10-26 ヒストンデアセチラーゼの阻害剤 Expired - Fee Related JP5583406B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US86334706P 2006-10-28 2006-10-28
US60/863,347 2006-10-28
US88428707P 2007-01-10 2007-01-10
US60/884,287 2007-01-10
PCT/US2007/082668 WO2008055068A2 (en) 2006-10-28 2007-10-26 Inhibitors of histone deacetylase

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014111281A Division JP5727649B2 (ja) 2006-10-28 2014-05-29 ヒストンデアセチラーゼの阻害剤

Publications (3)

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JP2010508296A JP2010508296A (ja) 2010-03-18
JP2010508296A5 true JP2010508296A5 (https=) 2010-12-02
JP5583406B2 JP5583406B2 (ja) 2014-09-03

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JP2009534891A Expired - Fee Related JP5583406B2 (ja) 2006-10-28 2007-10-26 ヒストンデアセチラーゼの阻害剤
JP2014111281A Expired - Fee Related JP5727649B2 (ja) 2006-10-28 2014-05-29 ヒストンデアセチラーゼの阻害剤
JP2015075545A Pending JP2015145401A (ja) 2006-10-28 2015-04-02 ヒストンデアセチラーゼの阻害剤

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JP2014111281A Expired - Fee Related JP5727649B2 (ja) 2006-10-28 2014-05-29 ヒストンデアセチラーゼの阻害剤
JP2015075545A Pending JP2015145401A (ja) 2006-10-28 2015-04-02 ヒストンデアセチラーゼの阻害剤

Country Status (19)

Country Link
US (4) US8399452B2 (https=)
EP (4) EP2049483A2 (https=)
JP (3) JP5583406B2 (https=)
KR (1) KR101312993B1 (https=)
CN (3) CN101573333B (https=)
AR (1) AR063720A1 (https=)
AU (1) AU2007313818B2 (https=)
BR (1) BRPI0718089A2 (https=)
CA (2) CA2667826C (https=)
CL (1) CL2007003108A1 (https=)
DK (1) DK2343286T3 (https=)
ES (1) ES2532899T3 (https=)
HK (1) HK1220179A1 (https=)
PL (1) PL2343286T3 (https=)
PT (1) PT2343286E (https=)
RU (1) RU2459811C2 (https=)
SI (1) SI2343286T1 (https=)
TW (3) TWI511961B (https=)
WO (1) WO2008055068A2 (https=)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030129724A1 (en) 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
CN101495116A (zh) 2005-03-22 2009-07-29 哈佛大学校长及研究员协会 蛋白降解病症的治疗
CN101535279B (zh) 2006-09-11 2015-05-20 柯瑞斯公司 含锌结合基的喹唑啉基egfr抑制剂
CA2663147A1 (en) 2006-09-11 2008-03-20 Curis, Inc. Substituted 2-indolinone as ptk inhibitors containing a zinc binding moiety
US7547781B2 (en) 2006-09-11 2009-06-16 Curis, Inc. Quinazoline based EGFR inhibitors containing a zinc binding moiety
AU2007296743B2 (en) 2006-09-11 2012-02-16 Curis, Inc. Tyrosine kinase inhibitors containing a zinc binding moiety
CN101573333B (zh) * 2006-10-28 2013-06-12 梅特希尔基因公司 组蛋白脱乙酰酶抑制剂
JP5208963B2 (ja) 2007-01-10 2013-06-12 エフ.ホフマン−ラ ロシュ アーゲー キマーゼ阻害剤としてのスルホンアミド誘導体
JP5401329B2 (ja) 2007-03-20 2014-01-29 キュリス,インコーポレイテッド Hsp90インヒビターとしての縮合アミノピリジン
CA2683557C (en) * 2007-04-09 2016-10-18 Methylgene Inc. Inhibitors of histone deacetylase
TW200922564A (en) 2007-09-10 2009-06-01 Curis Inc CDK inhibitors containing a zinc binding moiety
US8119616B2 (en) 2007-09-10 2012-02-21 Curis, Inc. Formulation of quinazoline based EGFR inhibitors containing a zinc binding moiety
EP2190287B1 (en) 2007-09-10 2014-10-29 Curis, Inc. Tartrate salts or complexes of quinazoline based egfr inhibitors containing a zinc binding moiety
BRPI0817897A2 (pt) * 2007-11-02 2019-09-24 Methylgene Inc composto, composição, e, métodos de inibição da atividade hdac, e de tratamento de uma doença responsiva a um inibidor de atividade hdac
ITFI20070288A1 (it) * 2007-12-21 2009-06-22 A I L Firenze Sezione Autonoma Inibitori delle deacetilasi istoniche
RU2515611C2 (ru) 2008-07-23 2014-05-20 Президент Энд Феллоуз Оф Гарвард Колледж Ингибиторы деацетилазы и их применение
WO2010018836A2 (ja) * 2008-08-11 2010-02-18 独立行政法人科学技術振興機構 ポリグルタミン凝集阻害剤
WO2010062565A1 (en) * 2008-10-27 2010-06-03 Acadia Pharmaceuticals Inc. Muscarinic agonists
AU2010203512C1 (en) 2009-01-08 2013-10-17 Curis, Inc. Phosphoinositide 3-kinase inhibitors with a zinc binding moiety
CA2786715C (en) 2009-01-16 2019-05-21 Curis, Inc. Fused amino pyridines for the treatment of brain tumors
CN105669540A (zh) * 2009-01-28 2016-06-15 卡鲁斯治疗有限公司 Scriptaid电子等排体及其在治疗中的用途
AR077033A1 (es) 2009-06-11 2011-07-27 Hoffmann La Roche Compuestos inhibidores de las quinasas de janus y su uso en el tratamiento de enfermedades inmunologicas
US8431538B2 (en) 2009-07-22 2013-04-30 The Board Of Trustees Of The University Of Illinois HDAC inhibitors and therapeutic methods of using same
US8952034B2 (en) 2009-07-27 2015-02-10 Gilead Sciences, Inc. Fused heterocyclic compounds as ion channel modulators
WO2011019393A2 (en) 2009-08-11 2011-02-17 President And Fellows Of Harvard College Class- and isoform-specific hdac inhibitors and uses thereof
EP2638009A4 (en) * 2010-01-08 2014-06-11 Harvard College FLUORINATED HDAC HEMMER AND USES THEREOF
US20110245154A1 (en) * 2010-03-11 2011-10-06 Hemaquest Pharmaceuticals, Inc. Methods and Compositions for Treating Viral or Virally-Induced Conditions
BR112012033402A2 (pt) 2010-07-02 2017-01-24 Gilead Sciences Inc moduladores de canais de íons conforme os compostos heterocíclicos fundidos
BR112013011868A2 (pt) * 2010-11-16 2016-08-23 Acetylon Pharmaceuticals Inc compostos de pirimidina hidróxi amida como inibidores da proteína desacetilase, composição farmacêutica e uso dos referidos compostos
US8404738B2 (en) 2011-01-21 2013-03-26 Hoffmann-La Roche Inc. 4-amino-N-hydroxy-benzamides for the treatment of cancer
CN103328446B (zh) * 2011-01-21 2016-01-20 霍夫曼-拉罗奇有限公司 用于治疗癌症的新的4-氨基-n-羟基-苯甲酰胺
WO2012106343A2 (en) * 2011-02-01 2012-08-09 The Board Of Trustees Of The University Of Illinois Hdac inhibitors and therapeutic methods using the same
AR085572A1 (es) * 2011-03-26 2013-10-09 Envivo Pharmaceuticals Inc Metodos de tratamiento dirigidos de la degeneracion lobular frontotemporal
DK3111938T3 (da) 2011-04-01 2019-07-01 Curis Inc Phosphoinositid 3-kinase-hæmmer med en zink-bindende gruppe
CA2834164A1 (en) 2011-05-10 2012-11-15 Gilead Sciences, Inc. Fused benzoxazinones as ion channel modulators
NO3175985T3 (https=) 2011-07-01 2018-04-28
TW201837023A (zh) 2011-07-01 2018-10-16 美商基利科學股份有限公司 作為離子通道調節劑之稠合雜環化合物
US9187439B2 (en) 2011-09-21 2015-11-17 Inception Orion, Inc. Tricyclic compounds useful as neurogenic and neuroprotective agents
WO2013052110A1 (en) * 2011-10-03 2013-04-11 The Trustees Of Columbia University In The City Of New York Novel molecules that selectively inhibit histone deacetylase 6 relative to histone deacetylase 1
WO2013101600A1 (en) * 2011-12-29 2013-07-04 Pharmacyclics, Inc. Cinnamic acid hydroxyamides as inhibitors of histone deacetylase 8
CN103788014B (zh) * 2012-10-29 2016-04-27 安徽安腾药业有限责任公司 制备10H-二苯并[b,f][1,4]硫氮杂卓-11-酮和喹硫平的方法
JP6329958B2 (ja) 2012-11-07 2018-05-23 カルス セラピューティクス リミテッド 新規ヒストンデアセチラーゼインヒビターおよび治療におけるその使用
NZ714283A (en) * 2013-05-10 2020-04-24 Karus Therapeutics Ltd Novel histone deacetylase inhibitors
ES2929576T3 (es) 2013-10-08 2022-11-30 Acetylon Pharmaceuticals Inc Combinaciones de inhibidores de histona deacetilasa 6 y el inhibidor de Her2 lapatinib para el uso en el tratamiento del cáncer de mama
WO2015054474A1 (en) 2013-10-10 2015-04-16 Acetylon Pharmaceuticals, Inc. Pyrimidine hydroxy amide compounds as histone deacetylase inhibitors
US10660890B2 (en) 2013-10-24 2020-05-26 National Institutes Of Health (Nih), U.S. Dept. Of Health And Human Services (Dhhs), U.S. Government Nih Division Of Extramural Inventions And Technology Resources (Deitr) Treatment of polycystic diseases with an HDAC6 inhibitor
CR20160308A (es) 2013-12-03 2016-11-08 Acetylon Pharmaceuticals Inc Combinaciones de inhibidores de histona deacetilasa y farmacos inmunomoduladores
WO2015100363A1 (en) 2013-12-23 2015-07-02 The Trustees Of Columbia University In The City Of New York Selective hdac6 inhibitors
US9464073B2 (en) 2014-02-26 2016-10-11 Acetylon Pharmaceuticals, Inc. Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors
SG11201700094TA (en) 2014-07-07 2017-02-27 Acetylon Pharmaceuticals Inc Treatment of leukemia with histone deacetylase inhibitors
US10118890B2 (en) 2014-10-10 2018-11-06 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
GB201419228D0 (en) 2014-10-29 2014-12-10 Karus Therapeutics Ltd Compounds
GB201419264D0 (en) 2014-10-29 2014-12-10 Karus Therapeutics Ltd Compounds
US9937174B2 (en) 2014-12-05 2018-04-10 University of Modena and Reggio Emilia Combinations of histone deacetylase inhibitors and bendamustine
WO2016126726A1 (en) 2015-02-02 2016-08-11 Forma Therapeutics, Inc. Bicyclic [4,6,0] hydroxamic acids as hdac6 inhibitors
SG11201708622UA (en) 2015-02-02 2017-11-29 Forma Therapeutics Inc 3-aryl-4-amido-bicyclic [4,5,0] hydroxamic acids as hdac inhibitors
MX2017012939A (es) 2015-04-08 2018-05-22 Novartis Ag Terapias cd20, terapias cd22 y terapias de combinacion con una celula que expresa un receptor quimerico de antigeno (car) de cd19.
CN106279044B (zh) * 2015-05-28 2021-02-19 厦门市博瑞来医药科技有限公司 嘧啶异羟肟酸衍生物及其制备方法和应用
US10272084B2 (en) 2015-06-01 2019-04-30 Regenacy Pharmaceuticals, Llc Histone deacetylase 6 selective inhibitors for the treatment of cisplatin-induced peripheral neuropathy
US10836733B2 (en) 2015-09-03 2020-11-17 The Board Of Trustees Of The University Of Illinois HDAC inhibitors and therapeutic methods using the same
AR105911A1 (es) 2015-09-03 2017-11-22 Forma Therapeutics Inc Inhibidores de hdac8 bicíclicos fusionados [6,6]
WO2017142883A1 (en) 2016-02-16 2017-08-24 The Board Of Trustees Of The University Of Illinois Tetrahydroquinoline substituted hydroxamic acids as selective histone deacetylase 6 inhibitors
EP3445364A4 (en) 2016-04-19 2019-11-27 Acetylon Pharmaceuticals, Inc. HDAC INHIBITORS, ONLY OR IN COMBINATION WITH BTK INHIBITORS, FOR THE TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA
EP3472131B1 (en) 2016-06-17 2020-02-19 Forma Therapeutics, Inc. 2-spiro-5- and 6-hydroxamic acid indanes as hdac inhibitors
GB2567093A (en) 2016-07-15 2019-04-03 Viracta Therapeutics Inc Histone deacetylase inhibitors for use in immunotherapy
US20180127386A1 (en) 2016-10-20 2018-05-10 Forma Therapeutics, Inc. Methods using hdac11 inhibitors
WO2018089651A1 (en) * 2016-11-10 2018-05-17 Acetylon Pharmaceuticals, Inc. Phenyl and pyridinyl hydroxamic acids
WO2018165520A1 (en) 2017-03-10 2018-09-13 Vps-3, Inc. Metalloenzyme inhibitor compounds
CN107011238B (zh) * 2017-03-14 2020-05-01 北京化工大学 一类组蛋白去乙酰化酶抑制剂及其制备方法和用途
WO2018183701A1 (en) 2017-03-29 2018-10-04 The George Washington University Isoxazole hydroxamic acids as histone deacetylase 6 inhibitors
CN110730660A (zh) 2017-04-26 2020-01-24 伊利诺伊大学评议会 Nrf和HIF活化剂/HDAC抑制剂和使用其的治疗方法
WO2019173761A1 (en) 2018-03-09 2019-09-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services C-abl tyrosine kinase inhibitory compound embodiments and methods of making and using the same
US11535607B2 (en) 2018-04-20 2022-12-27 Valo Health, Inc. Isoindolines as HDAC inhibitors
CN112204017B (zh) 2018-04-27 2024-08-20 国立大学法人大阪大学 苯并异噁唑化合物
CN109020921B (zh) * 2018-07-10 2020-08-04 山东大学 一种组蛋白去乙酰化酶hdac6抑制剂及其制备方法与应用
SG11202102343QA (en) 2018-09-11 2021-04-29 Curis Inc Combination therapy with a phosphoinositide 3-kinase inhibitor with a zinc binding moiety
CA3142142A1 (en) 2019-05-31 2020-12-03 Viracta Subsidiary, Inc. Methods of treating virally associated cancers with histone deacetylase inhibitors
IL292924A (en) 2019-11-26 2022-07-01 Novartis Ag Chimeric antigen receptors cd19 and cd22 and their uses
CN114315736B (zh) * 2020-03-30 2025-11-18 甫康(上海)健康科技有限责任公司 二氢化茚胺类衍生物、其制备方法和用途
CN113527206B (zh) * 2020-04-17 2022-12-30 上海中泽医药科技有限公司 一种苯并氮杂环类化合物、其制备方法及用途
CN112358455B (zh) * 2020-11-16 2022-07-19 吉林奥来德光电材料股份有限公司 一种二苯并七元杂环类化合物及其制备方法与应用
CN112500395B (zh) * 2020-12-02 2022-03-08 吉林奥来德光电材料股份有限公司 一种二苯并含氮七元杂环类有机化合物、其制备方法及有机电致发光器件
CN115073424A (zh) * 2021-03-10 2022-09-20 微境生物医药科技(上海)有限公司 组蛋白去乙酰化酶抑制剂及其应用
CN117580577A (zh) * 2021-06-29 2024-02-20 国立大学法人大阪大学 肾损伤的预防和/或治疗用医药组合物以及自噬活化剂
WO2023020416A1 (zh) * 2021-08-16 2023-02-23 勤浩医药(苏州)有限公司 三环化合物、包含其的药物组合物及其用途
IL316201A (en) 2022-04-08 2024-12-01 Eikonizo Therapeutics Inc Oxadiazole HDAC6 inhibitors and their uses
KR20250156746A (ko) * 2023-03-14 2025-11-03 미라링크 파마, 아이엔씨. 선택적 hdac6 억제제로서의 헤테로시클릭 화합물

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR901228A (fr) 1943-01-16 1945-07-20 Deutsche Edelstahlwerke Ag Système d'aimant à entrefer annulaire
US3510476A (en) * 1967-02-08 1970-05-05 American Home Prod Dibenzazepine-5-hydroxamic acid and derivatives thereof
DE2337154C2 (de) * 1973-07-18 1986-04-24 Schering AG, 1000 Berlin und 4709 Bergkamen Neue Carbazolderivate
CH620891A5 (en) 1975-12-19 1980-12-31 Teijin Ltd Isomerisation process
GB1574822A (en) * 1976-03-23 1980-09-10 Lafon Labor Acetohydroxamic acid derivatives and pharmaceutical compositions thereof
NZ194747A (en) * 1979-08-29 1988-11-29 Schering Ag 9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives
JPS5643283A (en) * 1979-08-29 1981-04-21 Schering Ag Betaacarbolinee33carboxylic acid derivative* its manufacture and psychotic medicine containing it
US5149797A (en) 1990-02-15 1992-09-22 The Worcester Foundation For Experimental Biology Method of site-specific alteration of rna and production of encoded polypeptides
GB9021813D0 (en) * 1990-10-08 1990-11-21 Ici Plc Tricyclic heterocycles
US5652355A (en) 1992-07-23 1997-07-29 Worcester Foundation For Experimental Biology Hybrid oligonucleotide phosphorothioates
US5512563A (en) * 1993-07-29 1996-04-30 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
DE19510957A1 (de) 1995-03-25 1996-09-26 Huels Chemische Werke Ag Eingedickter Bodenverfestiger, sowie diesen enthaltende verpackte Fertigmischung für Bodenbehandlungen
WO1996033983A1 (en) * 1995-04-25 1996-10-31 Daiichi Radioisotope Laboratories, Ltd. Dibenzoxazepine n-oxide derivatives and drug containing the same as the active ingredient
US6174905B1 (en) 1996-09-30 2001-01-16 Mitsui Chemicals, Inc. Cell differentiation inducer
AU731737B2 (en) 1996-10-16 2001-04-05 Wyeth Holdings Corporation The preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
US6117869A (en) * 1998-08-04 2000-09-12 Warner-Lambert Company Compounds for and methods of inhibiting matrix metalloproteinases
AR035311A1 (es) 1999-01-27 2004-05-12 Wyeth Corp Derivados de acido hidroxamico que contienen alquinilo, como inhibidores de las metalloproteinasas de matriz y de la tace, composicion farmaceutica y el uso de los mismos para la manufactura de un medicamento
DK1210326T3 (da) 1999-08-18 2004-06-21 Warner Lambert Co Hydroxamsyreforbindelser, der er nyttige som matrixmetalloproteinaseinhibitorer
KR20020070285A (ko) 1999-11-23 2002-09-05 메틸진, 인크. 히스톤 디아세틸라제의 억제제
AU2001248701A1 (en) 2000-03-24 2001-10-03 Methylgene, Inc. Inhibitors of histone deacetylase
AR035455A1 (es) * 2001-04-23 2004-05-26 Hoffmann La Roche Derivados triciclicos de alquilhidroxamato , procesos para su elaboracion, composiciones farmaceuticas que los contienen, y el uso de dichos compuestos en la preparacion de medicamentos
US6897220B2 (en) 2001-09-14 2005-05-24 Methylgene, Inc. Inhibitors of histone deacetylase
EP1429765A2 (en) 2001-09-14 2004-06-23 Methylgene, Inc. Inhibitors of histone deacetylase
EP1443928B1 (en) 2001-10-16 2011-07-27 Sloan-Kettering Institute For Cancer Research Treatment of neurodegenerative diseases and cancer of the brain
JP2005517007A (ja) * 2002-02-07 2005-06-09 アクシス・ファーマスーティカルズ ヒストンデアセチラーゼ阻害剤としての新規二環式ヒドロキサメート
ES2306859T3 (es) * 2002-03-13 2008-11-16 Janssen Pharmaceutica Nv Derivados de sulfonil como nuevos inhibidores de histona deacetilasa.
OA12793A (en) * 2002-03-13 2006-07-10 Janssen Pharmaceutica Nv Sulfonylamino-derivatives as novel inhibitors of histone deacetylase.
JP2006503082A (ja) 2002-10-17 2006-01-26 メシルジーン、インコーポレイテッド ヒストンデアセチラーゼの阻害剤
US7220431B2 (en) 2002-11-27 2007-05-22 Regents Of The University Of Minnesota Methods and compositions for applying pharmacologic agents to the ear
BRPI0407052A (pt) * 2003-01-27 2006-01-17 Pfizer Inibidores da hiv-integrase, composições farmacêuticas, e métodos para sua utilização
US7094791B2 (en) * 2003-07-31 2006-08-22 Avalon Pharmaceuticals, Inc. Derivatives of 3-hydroxy-pyrrole-2,4-dicarboxylic acid and uses thereof
US20060074124A1 (en) 2003-09-12 2006-04-06 Andrew Napper Methods of treating a disorder
KR101153335B1 (ko) 2003-09-24 2012-07-05 메틸진 인코포레이티드 히스톤 데아세틸라제의 억제제
US20050152323A1 (en) 2004-01-12 2005-07-14 Vincent Bonnassieux Plug-in Wi-Fi access point device and system
US7417040B2 (en) * 2004-03-01 2008-08-26 Bristol-Myers Squibb Company Fused tricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
US20050197336A1 (en) * 2004-03-08 2005-09-08 Miikana Therapeutics Corporation Inhibitors of histone deacetylase
CA2570903C (en) * 2004-07-26 2013-09-17 Applied Research Systems Ars Holding N.V. N-hydroxyamide derivatives and use thereof
EP1804804B1 (en) * 2004-09-21 2012-01-25 Hypnion, Inc. 3-[4-(DIBENZO[b,f][1,4]OXAZEPIN-11-YL)-PIPERAZIN-1-YL]-2,2-DIMETHYL PROPANOIC ACID FOR USE IN THE TREATMENT OF SLEEP DISORDERS
CA2596015A1 (en) * 2005-02-14 2006-08-24 Sampath K. Anandan Fused heterocyclic compounds useful as inhibitors of histone deacetylase
IT1362675B (it) * 2005-03-15 2009-06-25 Menarini Internat Operations Luxembourg Sa N-idrossiammidi -sostituiti con gruppi triciclici come inibitori dell'istone deacelitasi,loro preparazione ed impiego in formulazioni farmaceutiche
GB0510204D0 (en) 2005-05-19 2005-06-22 Chroma Therapeutics Ltd Enzyme inhibitors
JP5186372B2 (ja) 2005-08-16 2013-04-17 ジェネンテック, インコーポレイテッド 細胞/組織においてgalnac−t14発現を試験することによるapo2l/trailに対するアポトーシス感受性
KR101495611B1 (ko) * 2006-04-07 2015-02-25 메틸진 인코포레이티드 히스톤 데아세틸라아제의 억제제
CN101573333B (zh) * 2006-10-28 2013-06-12 梅特希尔基因公司 组蛋白脱乙酰酶抑制剂

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