JP2003528852A5 - - Google Patents

Download PDF

Info

Publication number
JP2003528852A5
JP2003528852A5 JP2001570615A JP2001570615A JP2003528852A5 JP 2003528852 A5 JP2003528852 A5 JP 2003528852A5 JP 2001570615 A JP2001570615 A JP 2001570615A JP 2001570615 A JP2001570615 A JP 2001570615A JP 2003528852 A5 JP2003528852 A5 JP 2003528852A5
Authority
JP
Japan
Prior art keywords
alkyl
group
alkoxy
amino
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2001570615A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003528852A (ja
JP4216502B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2001/009431 external-priority patent/WO2001072702A2/en
Publication of JP2003528852A publication Critical patent/JP2003528852A/ja
Publication of JP2003528852A5 publication Critical patent/JP2003528852A5/ja
Application granted granted Critical
Publication of JP4216502B2 publication Critical patent/JP4216502B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2001570615A 2000-03-24 2001-03-23 酸化窒素シンターゼ阻害剤として有用なアミジノ化合物 Expired - Fee Related JP4216502B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19192300P 2000-03-24 2000-03-24
US60/191,923 2000-03-24
PCT/US2001/009431 WO2001072702A2 (en) 2000-03-24 2001-03-23 Amidino compounds useful as nitric oxide synthase inhibitors

Publications (3)

Publication Number Publication Date
JP2003528852A JP2003528852A (ja) 2003-09-30
JP2003528852A5 true JP2003528852A5 (https=) 2008-05-08
JP4216502B2 JP4216502B2 (ja) 2009-01-28

Family

ID=22707469

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2001570616A Expired - Fee Related JP4205340B2 (ja) 2000-03-24 2001-03-23 酸化窒素シンターゼ阻害剤として有用なアミジノ化合物およびその塩
JP2001570615A Expired - Fee Related JP4216502B2 (ja) 2000-03-24 2001-03-23 酸化窒素シンターゼ阻害剤として有用なアミジノ化合物

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2001570616A Expired - Fee Related JP4205340B2 (ja) 2000-03-24 2001-03-23 酸化窒素シンターゼ阻害剤として有用なアミジノ化合物およびその塩

Country Status (21)

Country Link
US (5) US6403830B2 (https=)
EP (2) EP1265859B1 (https=)
JP (2) JP4205340B2 (https=)
KR (1) KR100835265B1 (https=)
CN (1) CN1294117C (https=)
AR (1) AR033359A1 (https=)
AT (2) ATE295832T1 (https=)
AU (4) AU4774501A (https=)
BR (1) BR0109386A (https=)
CA (2) CA2402199C (https=)
DE (2) DE60110902T2 (https=)
DK (2) DK1265859T3 (https=)
ES (2) ES2256223T3 (https=)
GE (1) GEP20094625B (https=)
MX (1) MXPA02009282A (https=)
MY (1) MY135721A (https=)
NZ (4) NZ520813A (https=)
PT (1) PT1265860E (https=)
TW (1) TWI294417B (https=)
WO (2) WO2001072702A2 (https=)
ZA (2) ZA200206459B (https=)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1265859T3 (da) * 2000-03-24 2006-05-01 Pharmacia Corp Amidinoforbindelser der er nyttige som nitrogenoxidsyntaseinhibitorer
US7393652B2 (en) 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
US8022058B2 (en) 2000-05-10 2011-09-20 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7879840B2 (en) 2005-08-25 2011-02-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7718644B2 (en) 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US7012098B2 (en) * 2001-03-23 2006-03-14 Pharmacia Corporation Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers
WO2002078617A2 (en) 2001-03-28 2002-10-10 University Of South Florida Materials and methods for treatment of cancer and identification of anti-cancer compounds
MY137736A (en) * 2001-04-03 2009-03-31 Pharmacia Corp Reconstitutable parenteral composition
DE10141650C1 (de) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
US20030109522A1 (en) * 2001-09-24 2003-06-12 Manning Pamela T. Ophthalmologic treatment methods using selective iNOS inhibitors
US20030119826A1 (en) * 2001-09-24 2003-06-26 Pharmacia Corporation Neuroprotective treatment methods using selective iNOS inhibitors
ES2297032T3 (es) * 2001-11-13 2008-05-01 Pharmacia Corporation Forma de dosificacion oral de parecoxib.
EP1505972A2 (en) * 2002-05-16 2005-02-16 Pharmacia Corporation A selective inos inhibitor and a pde inhibitor in combination for the treatment of respiratory diseases
CN1652843A (zh) * 2002-05-16 2005-08-10 法玛西雅公司 使用选择性iNOS抑制剂治疗呼吸系统疾病和病症
JP4485941B2 (ja) * 2002-06-05 2010-06-23 株式会社カネカ 光学活性α−メチルシステイン誘導体の製造方法
CA2494284A1 (en) * 2002-08-02 2004-02-12 Pharmacia Corporation Methods for treatment and prevention of gastrointestinal conditions
WO2004039772A1 (en) * 2002-11-01 2004-05-13 Pharmacia & Upjohn Company Llc Process for preparing s-(2-aminoethyl)-2-methyl-l-cysteine
US7544678B2 (en) 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
WO2004060352A1 (en) * 2002-12-19 2004-07-22 Pharmacia Corporation Non-hygroscopic formulation comprising a hydroscopic drug
WO2004064767A2 (en) * 2003-01-23 2004-08-05 Kahn Nighat N Nitric oxide inducing agents
DE10308580B3 (de) 2003-02-27 2004-09-09 Consortium für elektrochemische Industrie GmbH Verfahren zur elektrophilen Substitution von Thiazolidinen oder Oxazolidinen
EP1603450A4 (en) 2003-03-07 2009-07-29 Univ Columbia PROCEDURE BASED ON TYPE 1 RYANODIN RECEPTOR
BRPI0408275A (pt) * 2003-03-11 2006-03-07 Pharmacia Corp métodos para a remoção seletiva de contra-ìons de compostos e compostos derivados de tais métodos
WO2004080956A1 (en) * 2003-03-11 2004-09-23 Pharmacia Corporation S-[2-[(1-iminoethyl)amino]ethyl]-2-methyl-l-cysteine maleate hydrochloride crystalline salt
WO2004080953A1 (en) * 2003-03-11 2004-09-23 Pharmacia Corporation S-[2-[(1-iminoethyl)amino]ethyl]-2-methyl-l-cysteine salicylate monohydrate crystalline salt
MXPA05009302A (es) * 2003-03-11 2005-10-05 Pharmacia Corp Sal cristalina de maleato de s-[2-[(1-iminoetil)amino]etil]-2-metil-l-cisteina.
JP2006519839A (ja) * 2003-03-11 2006-08-31 ファルマシア・コーポレーション S−[2−[(1−イミノエチル)アミノ]エチル]−2−メチル−l−システインマレエートii型結晶塩
US20040186046A1 (en) * 2003-03-17 2004-09-23 Pfizer Inc Treatment of type 1 diabetes with PDE5 inhibitors
WO2004090152A1 (ja) * 2003-04-08 2004-10-21 Mitsubishi Gas Chemical Company, Inc. 2-アルキルシステインアミド又はその塩、並びに、それらの製造方法及び用途
WO2005049557A1 (ja) * 2003-11-18 2005-06-02 Mitsubishi Gas Chemical Company, Inc. 光学活性2−アルキルシステインの製造方法、並びにその誘導体及び製造方法
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
US20060154981A1 (en) * 2005-01-12 2006-07-13 Alcon, Inc. Method of reducing intraocular pressure and treating glaucoma
US7704990B2 (en) 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
CA2641262A1 (en) * 2006-02-02 2007-08-16 University Of South Florida Withacnistin compounds for treatment of cancer
US20070219223A1 (en) * 2006-03-07 2007-09-20 Endacea, Inc. Compositions and methods for treating respiratory disorders
US20090186854A1 (en) * 2006-03-23 2009-07-23 Meditor Pharmaceuticals Ltd. S-alkylisothiouronium derivatives for the treatment of inflammatory diseases
US7820689B2 (en) * 2006-08-10 2010-10-26 Hua-Lin Wu Methods and compositions for preventing or treating cardiovascular disease
CN101758337B (zh) * 2009-12-03 2012-02-15 湖南阿斯达生化科技有限公司 一种助焊剂用非卤素活性剂
BR112012024565B1 (pt) 2010-03-26 2022-02-08 Trustees Of Dartmouth College Proteína de fusão vista imunossupressora multimérica isolada ou recombinante e composição
US10745467B2 (en) 2010-03-26 2020-08-18 The Trustees Of Dartmouth College VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders
US20150231215A1 (en) 2012-06-22 2015-08-20 Randolph J. Noelle VISTA Antagonist and Methods of Use
US9293197B2 (en) 2011-08-15 2016-03-22 Lockheed Martin Corporation Reconfigurable phase change material masks for electro-optical compressive sensing
DK3421486T5 (da) 2012-06-22 2024-09-16 The Trustees Of Darthmouth College Nye Vista-IG-konstruktioner og anvendelse af Vista-IG til behandling af autoimmune, allergiske og inflammatoriske lidelser
US9890215B2 (en) 2012-06-22 2018-02-13 King's College London Vista modulators for diagnosis and treatment of cancer
JP6368308B2 (ja) 2012-09-07 2018-08-01 トラスティーズ・オブ・ダートマス・カレッジ 癌の診断および治療のためのvista調節剤
US9340446B1 (en) 2013-02-04 2016-05-17 Lockheed Martin Corporation Optical apparatus and method of forming a gradient index device
JP5953429B2 (ja) 2013-05-02 2016-07-20 株式会社エーピーアイ コーポレーション α−置換システインもしくはその塩又はα−置換システイン合成中間体の製造方法
EP3043788B1 (en) * 2013-09-13 2023-06-07 Replicon Health OY D-glyceric acid or dl-glyceric acid for use in the treatment of degeneration diseases related to aging
US11014987B2 (en) 2013-12-24 2021-05-25 Janssen Pharmaceutics Nv Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
RS63295B1 (sr) 2013-12-24 2022-06-30 Janssen Pharmaceutica Nv Anti-vista antitela i fragmenti
MX389695B (es) 2014-06-11 2025-03-20 Kathy A Green Uso de agonistas y antagonistas vista para suprimir o aumentar la inmunidad humoral.
US10437083B1 (en) 2014-10-20 2019-10-08 Lockheed Martin Corporation Individually addressable infrared mask array
JP2018505911A (ja) 2014-12-05 2018-03-01 イミュネクスト,インコーポレーテッド 推定上のvista受容体としてのvsig8の同定と、vista/vsig8調節剤を産生するためのその使用
WO2016207717A1 (en) 2015-06-24 2016-12-29 Janssen Pharmaceutica Nv Anti-vista antibodies and fragments
GB201512635D0 (en) 2015-07-17 2015-08-26 Ucl Business Plc Uses of therapeutic compounds
US10899836B2 (en) 2016-02-12 2021-01-26 Janssen Pharmaceutica Nv Method of identifying anti-VISTA antibodies
CN109789201B (zh) 2016-04-15 2023-06-16 伊穆奈克斯特股份有限公司 抗人vista抗体及其用途
US9969647B2 (en) 2016-05-17 2018-05-15 Lockheed Martin Energy, Llc Glass composites having a gradient index of refraction and methods for production thereof
US9908808B1 (en) 2016-08-18 2018-03-06 Lockheed Martin Corporation Ternary glass materials with low refractive index variability
EP3398941A1 (en) * 2017-05-03 2018-11-07 AXXAM S.p.A. Heterocyclic p2x7 antagonists

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2036770C (en) 1990-02-26 2003-09-09 Jeffrey P. Whitten Inhibitors of nitric oxide biosynthesis
US5132453A (en) 1991-03-22 1992-07-21 Cornell Research Foundation, Inc. N6 -(hydrazinoiminomethyl)lysine and method of inhibiting nitric oxide formation in body
JP2648897B2 (ja) 1991-07-01 1997-09-03 塩野義製薬株式会社 ピリミジン誘導体
GB9127376D0 (en) 1991-12-24 1992-02-19 Wellcome Found Amidino derivatives
GB9203347D0 (en) 1992-02-17 1992-04-01 Wellcome Found Hypolipidaemic compounds
DE4234867A1 (de) * 1992-10-16 1994-04-21 Degussa Verfahren zur Herstellung von Aminoalkylhydantoin und Aminoalkyl-alpha-aminosäuren
IL107771A0 (en) 1992-11-27 1994-02-27 Wellcome Found Pharmaceutical compositions containing isothiourea derivatives certain such novel compounds and their preparation
WO1994014780A1 (en) 1992-12-18 1994-07-07 The Wellcome Foundation Limited Pyrimidine, pyridine, pteridinone and indazole derivatives as enzyme inhibitors
DE4324088A1 (de) * 1993-07-17 1995-01-19 Hoechst Ag Hochtemperatursupraleitende Massivkörper und Verfahren zu ihrer Herstellung
EP0724570B1 (en) 1993-10-21 1999-03-03 G.D. Searle & Co. Amidino derivatives useful as nitric oxide synthase inhibitors
WO1995011014A1 (en) 1993-10-21 1995-04-27 G.D. Searle & Co. Amidino derivatives useful as nitric oxide synthase inhibitors
GB9405211D0 (en) 1994-03-17 1994-04-27 Deas Alexander R Noise cancellation apparatus
PT751930E (pt) 1994-03-24 2000-04-28 Searle & Co Derivados amidino uteis como inibidores da sintetase de oxido nitrico
EP0957087B1 (en) * 1994-06-15 2002-12-04 The Wellcome Foundation Limited Intermediates useful in the preparation of enzyme inhibitors
US5994391A (en) 1994-09-13 1999-11-30 G.D. Searle And Company Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US5684008A (en) 1994-11-09 1997-11-04 G. D. Searle & Co. Aminotetrazole derivatives useful as nitric oxide synthase inhibitors
WO1996033175A1 (en) 1995-04-20 1996-10-24 G.D. Searle & Co. Cyclic amidino agents useful as nitric oxide synthase inhibitors
KR19990014671A (ko) 1995-05-10 1999-02-25 윌리암스로저에이. 고리형 아미딘으로부터 유도된 산화질소 신타제 저해제
GB9516709D0 (en) 1995-08-15 1995-10-18 Zeneca Ltd Medicament
US5830917A (en) 1995-09-11 1998-11-03 G. D. Searle & Co. L-N6 -(1-iminoethyl) lysine derivatives useful as nitric oxide synthase inhibitors
US5945408A (en) 1996-03-06 1999-08-31 G.D. Searle & Co. Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors
US5981511A (en) * 1996-03-06 1999-11-09 G.D. Searle & Co. Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors
MY117948A (en) * 1997-01-13 2004-08-30 Glaxo Group Ltd Nitride oxide synthase inhibitors.
WO1999029865A2 (en) 1997-12-12 1999-06-17 The Rockefeller University A protein belonging to the tnf superfamily, nucleic acids encoding same, and methods of use thereof
WO1999046240A2 (en) 1998-03-11 1999-09-16 G.D. Searle & Co. Halogenated amidino amino acid derivatives useful as nitric oxide synthase inhibitors
GB9811599D0 (en) * 1998-05-30 1998-07-29 Glaxo Group Ltd Nitric oxide synthase inhibitors
DK1265859T3 (da) * 2000-03-24 2006-05-01 Pharmacia Corp Amidinoforbindelser der er nyttige som nitrogenoxidsyntaseinhibitorer

Similar Documents

Publication Publication Date Title
JP2003528852A5 (https=)
RU2002107975A (ru) Глюкопиранозилоксипиразольные производные, лекарственные композиции, содержащие эти производные, и промежуточные соединения для их получения
JP2002508352A5 (ja) 4(3)置換−4(3)−アミノメチル−(チオ)ピラン又はピペリジン誘導体(=ガバペンチン類似体)
RU2397168C2 (ru) Производные тиофена в качестве ингибиторов снк 1
JP2005523922A5 (https=)
JP2005506348A5 (https=)
JP2006501295A5 (https=)
JP2010508296A5 (https=)
RU2005100836A (ru) Производные пептидов, содержащие тиазепиновую группу, для лечения гиперлипемических состояний
RU2008106058A (ru) Производные пиридазинона в качестве агонистов рецептора тиреоидного гормона
EP1797878A3 (en) Benzothiazole derivatives
RU2004104625A (ru) Аналоги простагландинов в качестве агонистов рецептора ep4
JP2016509591A5 (https=)
JP2010077141A5 (https=)
JP2008509166A5 (https=)
RU95120598A (ru) Производные 10,11-метандибензосуберана, используемые в качестве хемосенсибилизующих агентов
JP2007502806A5 (https=)
JP2003506354A5 (https=)
JP2020507589A5 (https=)
JPWO2020123827A5 (https=)
JPH10279578A5 (https=)
KR970014765A (ko) 신경보호제를 이용한 이명의 치료
KR890005031A (ko) L-도파유도체 또는 그의 산부가염, 그의 제조방법 및 그의 용도
JP2005508368A5 (https=)
RU2004139050A (ru) Производные 1-сульфонил-4-аминоалкоксииндола в качестве модуляторов 5-нт6 рецептора для лечения заболеваний цнс