JP2022527556A5 - - Google Patents

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Publication number
JP2022527556A5
JP2022527556A5 JP2021559254A JP2021559254A JP2022527556A5 JP 2022527556 A5 JP2022527556 A5 JP 2022527556A5 JP 2021559254 A JP2021559254 A JP 2021559254A JP 2021559254 A JP2021559254 A JP 2021559254A JP 2022527556 A5 JP2022527556 A5 JP 2022527556A5
Authority
JP
Japan
Prior art keywords
methyl
product according
pharmaceutical product
phenyl
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021559254A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022527556A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/026625 external-priority patent/WO2020206289A1/en
Publication of JP2022527556A publication Critical patent/JP2022527556A/ja
Publication of JP2022527556A5 publication Critical patent/JP2022527556A5/ja
Pending legal-status Critical Current

Links

JP2021559254A 2019-04-05 2020-04-03 プロテインアルギニンメチルトランスフェラーゼ５の選択的阻害剤 Pending JP2022527556A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962830019P 2019-04-05 2019-04-05
US62/830,019 2019-04-05
PCT/US2020/026625 WO2020206289A1 (en) 2019-04-05 2020-04-03 Selective inhibitors of protein arginine methyltransferase 5

Publications (2)

Publication Number Publication Date
JP2022527556A JP2022527556A (ja) 2022-06-02
JP2022527556A5 true JP2022527556A5 (https=) 2023-04-07

Family

ID=72666997

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021559254A Pending JP2022527556A (ja) 2019-04-05 2020-04-03 プロテインアルギニンメチルトランスフェラーゼ５の選択的阻害剤

Country Status (4)

Country Link
US (1) US20220152072A1 (https=)
EP (1) EP3952874A4 (https=)
JP (1) JP2022527556A (https=)
WO (1) WO2020206289A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11077101B1 (en) 2018-07-18 2021-08-03 Tango Therapeutics, Inc. Compounds and methods of use
US12403137B2 (en) 2019-10-28 2025-09-02 Tango Therapeutics, Inc. Compounds and methods of use
WO2022026892A1 (en) 2020-07-31 2022-02-03 Tango Therapeutics, Inc. Piperidin-1- yl-n-pyrydi ne-3-yl-2-oxoacet am ide derivatives useful for the treatment of mtap-deficient and/or mt a-accumulating cancers
JP2024508235A (ja) * 2021-02-04 2024-02-26 アムジエン・インコーポレーテツド 三環－アミド－二環ｐｒｍｔ５阻害剤
US20240262857A1 (en) * 2021-05-27 2024-08-08 Emory University Novel universal anti-rna virus agents
CN113546173B (zh) * 2021-08-19 2022-08-23 徐州医科大学 Prmt5抑制剂在制备治疗冠状病毒感染所引起的疾病的药物中的应用
KR20250004026A (ko) * 2022-07-15 2025-01-07 아비스코 테라퓨틱스 컴퍼니 리미티드 Prmt5 억제제, 그 제조 방법과 약학에서의 응용
WO2024170488A1 (en) 2023-02-13 2024-08-22 Astrazeneca Ab Prmt5 inhibitor for use in cancer therapy
EP4553080A1 (en) * 2023-11-07 2025-05-14 Ustav Organicke Chemie a Biochemie AV CR, v.v.i. Nucleoside derivatives as antiviral agents against coronaviruses
US20250313552A1 (en) * 2024-04-04 2025-10-09 New Frontier Bio, Inc. Nicotinate esters and therapeutic methods of use thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL108523A0 (en) * 1993-02-03 1994-05-30 Gensia Inc Pharmaceutical compositions containing adenosine kinase inhibitors for preventing or treating conditions involving inflammatory responses and pain
US6495579B1 (en) * 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
ES2334924T3 (es) * 2005-03-17 2010-03-17 Proyecto De Biomedicina Cima, S.L. Empleo de 5'-metiltioadenosina (mta) en la prevencion y/o tratamiento de enfermedades autoinmunes y/o rechazo de trasplantes.
PT2231689T (pt) * 2008-01-18 2016-10-07 Inst Of Organic Chemistry And Biochemistry Of The Acad Of Sciences Of The Czech Republic Novos nucleósidos 7-deazapurina citostáticos
KR20120113228A (ko) * 2009-12-18 2012-10-12 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 베타 세포 복제 촉진 화합물 및 그 사용 방법
US20170198006A1 (en) * 2014-06-25 2017-07-13 Epizyme, Inc. Prmt5 inhibitors and uses thereof
WO2016079321A1 (en) * 2014-11-20 2016-05-26 Cemm Forschungszentrum Für Molekulare Medizin Gmbh Antagonists of setdb2 for use in the therapy of infectious diseases
TWI870767B (zh) * 2015-08-26 2025-01-21 比利時商健生藥品公司 使用作為prmt5抑制劑之新穎經6-6雙環芳香環取代之核苷類似物
WO2017120508A1 (en) * 2016-01-08 2017-07-13 Arcus Biosciences, Inc. Modulators of 5'-nucleotidase, ecto and the use thereof
WO2018081451A1 (en) * 2016-10-26 2018-05-03 Indiana University Research And Technology Corporation Small molecule protein arginine methyltransferase 5 (prmt5) inhibitors and methods of treatment
EP3939986A1 (en) * 2017-08-09 2022-01-19 Prelude Therapeutics, Incorporated Selective inhibitors of protein arginine methyltransferase 5 (prmt5)
US12552826B2 (en) * 2018-08-07 2026-02-17 Merck Sharp & Dohme Llc PRMT5 inhibitors
US11981701B2 (en) * 2018-08-07 2024-05-14 Merck Sharp & Dohme Llc PRMT5 inhibitors

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