JP4856849B2 - 自律携帯式検体監視装置又は薬剤送給装置 - Google Patents
自律携帯式検体監視装置又は薬剤送給装置 Download PDFInfo
- Publication number
- JP4856849B2 JP4856849B2 JP2003565550A JP2003565550A JP4856849B2 JP 4856849 B2 JP4856849 B2 JP 4856849B2 JP 2003565550 A JP2003565550 A JP 2003565550A JP 2003565550 A JP2003565550 A JP 2003565550A JP 4856849 B2 JP4856849 B2 JP 4856849B2
- Authority
- JP
- Japan
- Prior art keywords
- microchannel
- microneedles
- monitoring
- microneedle
- fluid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150977—Arrays of piercing elements for simultaneous piercing
- A61B5/150984—Microneedles or microblades
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/14—Devices for taking samples of blood ; Measuring characteristics of blood in vivo, e.g. gas concentration within the blood, pH-value of blood
- A61B5/1405—Devices for taking blood samples
- A61B5/1411—Devices for taking blood samples by percutaneous method, e.g. by lancet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
- A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
- A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/150022—Source of blood for capillary blood or interstitial fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
- A61B5/150061—Means for enhancing collection
- A61B5/150076—Means for enhancing collection by heating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150213—Venting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
- A61B5/150381—Design of piercing elements
- A61B5/150389—Hollow piercing elements, e.g. canulas, needles, for piercing the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
- A61B5/150381—Design of piercing elements
- A61B5/150503—Single-ended needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
- A61B5/150381—Design of piercing elements
- A61B5/150526—Curved or bent needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150755—Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150847—Communication to or from blood sampling device
- A61B5/15087—Communication to or from blood sampling device short range, e.g. between console and disposable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150969—Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15101—Details
- A61B5/15103—Piercing procedure
- A61B5/15107—Piercing being assisted by a triggering mechanism
- A61B5/15109—Fully automatically triggered, i.e. the triggering does not require a deliberate action by the user, e.g. by contact with the patient's skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15101—Details
- A61B5/15115—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids
- A61B5/15119—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids comprising shape memory alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15101—Details
- A61B5/15115—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids
- A61B5/15123—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids comprising magnets or solenoids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15146—Devices loaded with multiple lancets simultaneously, e.g. for serial firing without reloading, for example by use of stocking means.
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15146—Devices loaded with multiple lancets simultaneously, e.g. for serial firing without reloading, for example by use of stocking means.
- A61B5/15148—Constructional features of stocking means, e.g. strip, roll, disc, cartridge, belt or tube
- A61B5/15149—Arrangement of piercing elements relative to each other
- A61B5/15153—Multiple piercing elements stocked in a single compartment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
- A61B5/15146—Devices loaded with multiple lancets simultaneously, e.g. for serial firing without reloading, for example by use of stocking means.
- A61B5/15148—Constructional features of stocking means, e.g. strip, roll, disc, cartridge, belt or tube
- A61B5/15157—Geometry of stocking means or arrangement of piercing elements therein
- A61B5/15159—Piercing elements stocked in or on a disc
- A61B5/15163—Characterized by propelling the piercing element in an axial direction relative to the disc
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/155—Devices specially adapted for continuous or multiple sampling, e.g. at predetermined intervals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/157—Devices characterised by integrated means for measuring characteristics of blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6802—Sensor mounted on worn items
- A61B5/681—Wristwatch-type devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/683—Means for maintaining contact with the body
- A61B5/6832—Means for maintaining contact with the body using adhesives
- A61B5/6833—Adhesive patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/04—Constructional details of apparatus
- A61B2560/0406—Constructional details of apparatus specially shaped apparatus housings
- A61B2560/0412—Low-profile patch shaped housings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/04—Constructional details of apparatus
- A61B2560/0443—Modular apparatus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2209/00—Ancillary equipment
- A61M2209/08—Supports for equipment
- A61M2209/088—Supports for equipment on the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/20—Blood composition characteristics
- A61M2230/201—Glucose concentration
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Pathology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgery (AREA)
- Hematology (AREA)
- Optics & Photonics (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Anesthesiology (AREA)
- Geometry (AREA)
- Pain & Pain Management (AREA)
- Ecology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Manufacturing & Machinery (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Description
図1は本発明による検体監視装置、又はドラグ(薬剤)送給装置10の一部を絵画的な線図で示している。この装置はハウジング(下部のみを示す)12を有し、キャリヤ16上に配置された複数個のマイクロニードル14と、電子部分18とをこのハウジングが包囲している。キャリヤ16は図1に示すように、円形輪郭を有するほぼ平坦な基材である。キャリヤ16は本発明の範囲内において、種々の幾何学形状に形成し得ることは明らかである。
3つの例示のシステムモジュールは使用者が使い易いこと、診断上の関係、安価な検体監視、薬剤送給のシステムの要求に最適に整合するように特定されている。検体監視、及び薬剤送給システムは使い捨てモジュール、再使用可能モジュール、及びPDAモジュールに区分されている。例えば、図27を参照されたい。この形態は確実な利点を達成するため、これ等3つの形態の中で機能を最適に分散させている。しかし、本発明はこの形態に限定されない。例えば、全ての電子工学部品、マイクロニードル、化学物質、機械的部品、及び使用者インタフェースを含む一ユニットの使い捨て装置を代案として採用してもよい。又は、最も適切には、本発明の設計により、1個、又はそれ以上のシステムモジュール間に、構成部分をどのようにでも分散させることができる。例えば、全体のシステム費用、使用者の安全性、及び/又は性能の関心に基づいて、1個、又はそれ以上のシステムモジュールの中で、構成部分を区分することができる。
このモジュールには一度使用して、生物学的安全性と、診断の正確性とを維持するため、廃棄しなければならない構成部分を含んでいる。このモジュールには、完全性、滅菌性、及びいかなる再使用可能な構成部分へのインタフェースをも維持するための構造素子、又は機械的素子をも含んでいるのが好適である。従って、このシステムモジュールにはマイクロニードル、マイクロ流体組立体、隔膜、試薬の化学、及び関連ハウジング材料を含むのが好適である。また、このモジュールは身体に密着し、その密着を維持するための保持機構を含むことができ、これにより検体の監視システム、及び薬剤送給システムの機械的な保持を行う。
このモジュールは制御、運動の自動化、グルコース反応の測定、使用者への警告、PDAモジュールへのデータの転送を行う構成部分を含んでいるのが好適である。また、このモジュールは身体への密接を達成し、その維持のための保持機構を含んでいて、検体監視システム、及び薬剤送給システムのための機械的保持を行う。また、このモジュールは関連する回路(例えば電子工学に対応する記憶装置)を有するマイクロプロセッサ、何かの反応(例えばグルコース反応)の生成物を判断するためのセンサ(例えば電子工学センサ)、モータ等の駆動機構、センサ、電源(例えば電池)36、及び可搬式計算装置、又はPDAに通信するように作用するインタフェースを有しているのが好適である。このインタフェースはRF、磁気的、誘導的、光学的等なものにすることができる。RF結合を使用するよりも、磁気結合、又は誘導結合を使用するのが有利であり、それは後者の方がFCC制約、又は制限を避ける可能性があるためである。また、再使用可能モジュールには使用者の行動に干渉を必要とすることを使用者に知らせるための音響による、又は振動による警報手段を有することもできる。
このモジュールにはこの装置を制御し、及び/又はこの装置に相互に作用し合うためのパーソナルディジタルアシスタント(PDA)、手で持つことができるコンピュータのような可搬式コンピュータ装置を介する別個の使用者インタフェースを有するのが好適である。代表的な可搬式コンピュータ装置としては、プロセッサ、メモリ、関連する回路、ディスプレイ(例えば、単色ディスプレイ、又はカラー液晶ディスプレイ)、及びキーパッドのような入力装置、タッチスクリーン(例えばディスプレイと一体のもの)等、及び作動システムがある。以前に入手可能であったグルコースモニタはペーパ試験条片を取り扱うため、グルコース測定値の数値を見るため、及びそのキャリブレーションのようにメータの他のパラメータを設定するため特に設計されたものである。これ等の顧客向けに設計されたユニットは機能が制約されており、使用者のインタフェースが不十分であった。
本発明は注射、又は血液の採取に、今日、最も多く使用される針よりも一層小さい針であって、ここでマイクロニードルと称するニードルを突出させるように作動する機構を包含する。マイクロニードルを使用すれば、最少の不快感、又は最少の苦痛で血液を抽出することができる。蚊に例えられるこのマイクロニードルによる血液の抽出は有効であることが注目されている。ミクロンの太さの中空部材を通じて、血液を引き出している間、基本的に苦痛無く、血液を抽出するという人間ではできないことを行うように、この昆虫、即ちマイクロニードルは管理されている。
種々のセンサ構造を本発明では使用することができる。例えば比色分析、及び蛍光発光のような技術によって、光学的検出を行うことができる。図16はマイクロニードル514に流体連通しているマイクロチャネル520、及び反応層521を有する基本形態を示している。反応層を隔膜にすることができ、この隔膜には化学的に活性な成分をコーティングし、比色分析の測定のため、希望する検体(例えば、グルコース)の存在の場合に、この活性成分によって色を変化させる。マイクロニードル514を通じて、流体試料を捕集し、マイクロチャネル520内に保管する。適切な試薬をマイクロチャネル520内に収容するのが好適であり、これにより、流体試料を捕集すると、反応を開始する。マイクロチャネル520の上方にセンサを配置し、このセンサは適切な周波数の光で反応層を照射するように作用するエミッタ535を有する。また、このセンサは矢印539によって示すように、反応層から反射する光を検出するように作用する検出器537を有する。この検出器537は単一、又は複数の画像素子(ピクセル)を有する光ダイオードを使用して作動する。このような装置の例はCMOS、又はCCDイメージャがある。エミッタ、及び検出器はプロセッサ(図示せず)によって、制御されるのが良い。検出器の出力はこのプロセッサによって読み取られるのが好適であり、反応の結果を決定するため、更に処理される。図17a、及び図17bは感度を高めるため増強された捕集形態を示す。このセンサ形態には1個、又はそれ以上の個数のエミッタ535から、検出器537まで光を反射するための球状ミラー541を有する。
本発明は血液の捕集を強化するための種々の技術を有する。図20a、及び図20bは捕集位置に近い組織を加熱するための加熱源(例えば赤外線放出LED)の使用を示す。捕集位置で組織の毛細血管組織を加熱することによって、血液の供給を向上させ、マイクロニードルを使用する血液の捕集を増大する。図20aは皮膚、又は組織に挿入された例示のマイクロニードル514を示す。加熱源598をマイクロニードルの一側に設置して、組織に指向させ、これにより、マイクロニードルを挿入した組織を加熱する。図20bは代案の実施例を示し、加熱源599はほぼ環状であり、マイクロニードル514の周りに同軸に設置されている。
血液の捕集を簡単化し、十分な試料を得ることを確実にするため、本発明は血液検出センサの使用を包含する。この血液検出センサは貫入と抽出とについての制御を提供する。このセンサのフィードバックループはマイクロニードルを皮膚の中に少しづつ駆動することによって作動し、血液がマイクロニードルを充たすための適切な時間を待って、次にセンサはマイクロニードルを後退させる。図21を参照されたい。妥当な時間内に血液が検出されないと、モータはマイクロニードルを一層深い深さまで、更に駆動する。血液が得られると、マイクロニードルを後退させる。
1987年以来、米国糖尿病協会(ADA)は自己管理血糖値(SMBG)メータの統計上の査定のための判定基準を提供している。1987年には、血糖値の測定値は基準値の15%以内であるべきこと、及び将来のSMBGメータの変動値が10%以下であるべきことをADAが推薦した。1993年までに、この当時の新しい技術では1987年の目標を達成できないことが明らかになった。しかし、1996年には、ADAは将来のSMBGメータに対し5%以下の変動値を推薦した。
ベータ−D−グルコース+O2 +H2O =D−グルコン酸+H2O2 (1)
2H2O+4−アミノアンチピリン+1.7−ジヒドロキシナフタリン=赤色色素 (2)
この反応は第1反応に関して、酸化酵素が存在しており、第2反応に関して、ペルオキシダーゼが存在している状態で発生する。トリンダー反応はグルコース検査のために広く使用されている。トリンダー反応の重要な特徴は使用の長い歴史があること、上昇した温度で染色先駆物質の安定性、酵素の入手容易性と、酵素の熱に対する安定性である。1.7 −ジヒドロキシナフタリンはアルコールのみに溶性であり、水溶性の芳香性が好適である。この芳香性物質はDeluca等に与えられた米国特許第4350762 号に特定している水溶性試薬の一つが好適であり、例えば、2.4-ジクロロフェニルスルホン酸塩のナトリウム塩である。
酵素試験の精度を向上させるため、正しい結果を一層正確に決定するために使用すべき補正因子であるキャリブレーションファクタとして、試験条片の各バッチを現在のSMBGメータに設けることは助けになることがわかった。2つのキャリブレーションが必要であり、その第1は機器の構成部分を補正することであり、第2は化学的成分の特定の特別な感度を補正することである。このことを自動的に達成するため、種々の技術が開発されている。
本発明は必ずしもこれに限定されないが、酵素、抗体、アルコールレベル、その他の血液成分を含む種々の成分を試験するのに利用することができる。本発明はまたHbAlc (糖化ヘモグロビン)血液試験を組み込むように設計することができ、この試験は1年に2回、又はそれ以上行うべき糖尿病の試験であり、この試験は血糖値レベルを調整するのに長期間にわたり有効な手段を提供する。実際上、体温で、又は体温付近で使用し得る化学反応を有する血液試験はこのシステムに組み込むことができる。また、本発明は血液内の異物体を遺伝学的に確認するポリメラーゼ連鎖反応(PCR)試験を提供し得ると考えられる。二重核酸の熱融解を利用する試験に、比較的小さな加熱素子を使用することができる。包囲する構造の加熱を最小にするため、絶縁を使用することもできる。
本明細書を展望すれば、選択された例により、種々の比色分析法、電気化学的検査法、及び蛍光発光検査法を利用し得ることを示している。これ等の方法の中で、Zanzucchi に与えられた米国特許第6118126 号は蛍光発光検査技術を開示しており、本発明の装置のための代わりの検査方法として使用することもできる。この技術は織目加工された表面からの蛍光発光を増大させる。本発明に関連して、増大した蛍光発光は小さな試料の検査の感度を向上させる。本発明の範囲を逸脱することなく、種々の他の検査技術を使用し得ることは明らかである。
このシステムを使用者に親しみ易くするため、神経回路網のような人口知能構想を使用する単一学習アルゴリズムをこのシステムのコンピュータによって使用することができる。このアルゴリズムは多数の血液採取の歴史的なデータから、個々に特殊なパラメータを推論することができる。これ等の付加的な可変値は身体上の位置、最終の食事からの時間、最終の運動からの時間、日時である(毛細血管は日中、特に肉体的な活動の時間の間、一層血液に富んでいる)。これ等のデータを使用して、血液を採取できる可能性を推察し、従って、最適のマイクロニードル深さ、及びそのままにしておく時間を推察する。
不承諾の主要な理由の一つはグルコースの測定と、補償作用との間に緊密なフィードバックループがないことである。本発明はグルコースレベルの読み取りだけでなく、多少ともインシュリン、又は口経薬品、又は栄養補助食品に関する提言を行うことができる。
自動化された糖尿病管理ソフトウェアは以前から開発されており、血糖値レベルを制御する糖尿病患者を助けているが、形式の複雑なこと、及び一層多くの読み取りが不適切なため、大部分が失敗している。糖尿病管理ソフトウェアは糖尿病薬の調剤、又は食事の編成を変更し、高血糖症、又は低血糖症の発生を最少にする。これ等のシステムは各個人の血糖値が若干のレベルの干渉によってどのように変化するかを正確に予測するためには、長い歴史的な、またリアルタイムのデータが必要である。不幸にして、これ等のシステムは失敗しており、それは使用者の状態、及び生理学上の応答があまりにも予測できず、リアルタイムの血糖値の測定値に基づく短期間の予測のみが結果を変更するのを助けるのに使用できるだけである。
本発明は分離した場所に装着するから、グルコース値を決定するために装着したまま、物理的に、又は視覚的にアクセスしなければならない使用者にとって不便であるかもしれない。従って、使用者のグルコース値が決定値を越えつつあるか、一層低い所定レベルより下になっているかを決定するため、使用者が常にPDAに問いただす必要があってはならない。再使用可能ユニットに、直接通信するように変更し、Palm、又はHandspringによって生産されたような無線のパーソナルディジタルアシスタントを使用することは一層便利で、人間工学的に、そして社会的に受け入れられる。
融通性のある試験スケジュールのため、システムソフトウェアに、タイミングシステムを組み込むのが好適である。上に述べたように、使用者がそのグルコース値を試験しなければならない時、及び使用者が変わったため上限、下限を設定するため、使用者は時間をプログラミングすることができる。使用者が変更を行い、使用者からの確認があった場合、この情報がシステムに無線でダウンロードされるのが好適である。日中は、使用者はグルコース値の読み取りをチェックするようにシステムによって警告されない限り、PDAを使用する必要はない。使用者が直ちに測定を行うことを希望すれば、使用者はPDAから試験を開始することができる。使用者が一旦、この指令を選択し、それを確認し、それを再使用可能ユニットに転送すれば、PDAに対して確認が行われる。
本発明は身体上の種々の位置に、装置を設置する能力を有する。図28は本発明装置を設置するための身体上の例示の位置を絵画的に示す線図である。
Claims (34)
- 検体である対象物に対して流体処理するように作動し得る検体処理装置において、
複数個のマイクロニードルと、
前記複数個のマイクロニードルにそれぞれ導管を通じて少なくとも間欠的に流体連通した複数個のマイクロチャネルと、
前記対象物に向けて各マイクロニードルを突出させるように作動し得る少なくとも1個のアクチュエータと、
前記アクチュエータを作動させ、前記流体処理を開始するように作動し得る制御器と
を具え、
前記流体処理は、前記対象物から流体試料を引き出して監視する処理とし、
前記複数個のマイクロチャネルは、それぞれ前記流体試料に反応する試薬およびCMOSイメージャを有する少なくとも1個の検出器に関連させ、前記マイクロチャネルに捕集された前記流体試料が前記マイクロチャネルにおける試薬と反応を開始し、前記検出器は前記反応を検出するよう配置した、監視マイクロチャネルとし、
前記制御器は、前記流体試料を引き出して前記試薬に反応させる処理を開始するよう構成し、
前記反応を前記検出器によって監視する
ことを特徴とする検体処理装置。 - 前記複数個のマイクロニードルの各々が約25〜200ミクロンの範囲の内径を有している請求項1の装置。
- 前記複数個のマイクロニードルの各々が、金属、プラスチック、ガラス、及び結晶体のうちの少なくとも一つから製造されている請求項1の装置。
- 前記複数個のマイクロニードルの各々が、最大約2.5 mmまで、皮膚の表面内に貫入するよう作動し得る末端を有する請求項1の装置。
- 前記流体試料が実質的に血液である請求項1の装置。
- 各監視マイクロチャネルは前記流体試料を貯蔵するように作動可能であり、前記監視マイクロチャネル内の前記流体試料の蓄積は毛管力に全く依存している請求項1の装置。
- 毛管力を増大し、凝固を最少にするように、少なくとも1個の不溶性材料を少なくとも一部にコーティングした少なくとも1個の内面を前記監視マイクロチャネルのおのおのが有する請求項1の装置。
- 前記複数個の監視マイクロチャネルが一群のものとして製作されている請求項1の装置。
- 前記監視マイクロチャネルはほぼ5cmの最大直径内に形成されたほぼ50〜150個のマイクロチャネルを有する一群のものとして製作されている請求項1の装置。
- 前記複数個のマイクロニードルの各々は50〜500ナノリットルの範囲内の流体容積用に、寸法が定められている請求項1の装置。
- 前記流体試料が少なくとも1個の監視マイクロチャネルを完全に充填して、関連する前記マイクロニードルによって前記流体試料の蓄積が終了し得る時を決定するように作動し得る検出器を具える請求項1の装置。
- (a)グルコース、(b)コレステロール、(c)エタノール、(d)ジコキシン、(e)HDLコレステロール、(f)リチウム、(g)ナトリウム、(h)フェニトイン、(i)セロフィリン、(j)サイクロスポリン、(k)癌化学療法薬、(l)DNA、(m)RNA、(n)増量フェニトインナトリウム、(o)ワルファリンナトリウム、及び(p)血液から生じた蛋白質の群から選択された検体のための検査をするように作用し得る少なくとも1個の試薬に、少なくとも1個の監視マイクロチャネルが流体連通している請求項1の装置。
- 単一のマイクロニードルを使用して、多数の検査を行えるよう、少なくとも2個の監視マイクロチャネルを単一のマイクロニードルに関連させた請求項1の装置。
- 複数個の第2マイクロニードルと、キャリブレーション流体を充填した複数個のキャリブレーションマイクロチャネルとを具え、キャリブレーションの目的で、少なくとも1個の検査を開始する請求項1の装置。
- 複数個の第3マイクロニードルと、複数個の薬剤送給マイクロチャネルとを具え、各薬剤送給マイクロチャネルには少なくとも一部、薬剤を充填した請求項1の装置。
- 少なくとも1個の監視マイクロチャネルをポリマでシールした請求項1の装置。
- 前記制御器はタイムスケジュールに基づいて、検体処理を開始するように作動可能である請求項1の装置。
- 前記制御器は検体処理タイムスケジュールを調整するように作動可能である請求項17の装置。
- 前記制御器は可搬式コンピュータ装置を結合するように作動可能である請求項1の装置。
- 前記可搬式コンピュータ装置がPDAである請求項19の装置。
- 前記制御器、及び前記可搬式コンピュータ装置の少なくとも一方が検体処理の時間を選択し、又は変更するように作動可能である請求項19の装置。
- 前記複数個のマイクロニードル、及び複数個の監視マイクロチャネルが使い捨てである請求項1の装置。
- 前記制御器、及び前記アクチュエータが再使用可能である請求項1の装置。
- 前記複数個のマイクロニードル、複数個の監視マイクロチャネル、アクチュエータ、及び制御器が可搬式である請求項1の装置。
- マイクロニードルを突出させる前に、少なくとも1個の注射位置を加熱するように作動し得る加熱源を具える請求項1の装置。
- 前記加熱源が光学加熱源である請求項25の装置。
- ハウジングを表面に取り付けるように作用し得る接着剤を少なくとも一部、コーティングしたハウジングを具え、前記複数個のマイクロニードル、及び前記監視マイクロチャネルを前記ハウジングが少なくとも一部、包囲している請求項1の装置。
- 前記複数個のマイクロニードル、及び前記監視マイクロチャネルを少なくとも一部包囲するほぼディスク状のハウジングを具える請求項1の装置。
- 検体である対象物対して流体処理するように作動し得る検体処理装置において、前記装置は
複数個のマイクロニードルと、
前記複数個のマイクロニードルに導管を通じて少なくとも間欠的に流体連通した複数個のマイクロチャネルと、
前記対象物に向けて前記マイクロニードルをそれぞれ突出させるように作動し得る少なくとも1個のアクチュエータと、
前記アクチュエータを作動させ、前記流体処理を開始するように作動し得る制御器と
を具え、
前記流体処理は、前記対象物から流体試料を引き出して監視する処理、および前記対象物に薬剤を送給する処理の双方を行うものとし、
前記複数個のマイクロチャネルのうち第1マイクロチャネルを、それぞれ前記流体試料に反応する試薬およびCMOSイメージャを有する少なくとも1個の検出器に関連させ、前記マイクロチャネルに捕集された前記流体試料が前記マイクロチャネルにおける試薬と反応を開始し、前記検出器は前記反応を検出するよう配置した、監視マイクロチャネルとし、
前記複数個のマイクロチャネルのうち第2マイクロチャネルを、それぞれ前記薬剤が充填されている、薬剤送給マイクロチャネルとし、
前記制御器は、前記対象物から流体試料を引き出して監視する処理および前記対象物に薬剤を送給する処理のいずれかを選択的に開始するよう構成した、
ことを特徴とする検体処理装置。 - 複数個の第3マイクロニードルと、キャリブレーション流体を充填した複数個のキャリブレーションマイクロチャネルとを具え、キャリブレーションの目的で少なくとも1個の検査を開始する請求項29の装置。
- 前記イメージャは、複数個のピクセルを有するものとして構成した請求項1記載の検体処理装置。
- さらに、前記監視マイクロチャンネルに関連して設けた少なくとも1個のエミッタを有するものとした請求項1記載の検体処理装置。
- 前記少なくとも1個の検出器は、前記試料における検体濃度を決定する読み取りを行う前に、前記監視マイクロチャンネルのうち少なくとも1個の監視マイクロチャンネルに血液が存在することを検出するよう動作する構成とした請求項1記載の検体処理装置。
- 前記検体を環境毒素とし、前記薬剤を前記毒素に対する解毒剤とした請求項15記載の検体処理装置。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35519502P | 2002-02-08 | 2002-02-08 | |
US60/355,195 | 2002-02-08 | ||
US10/131,268 US7004928B2 (en) | 2002-02-08 | 2002-04-23 | Autonomous, ambulatory analyte monitor or drug delivery device |
US10/131,268 | 2002-04-23 | ||
PCT/US2003/003536 WO2003066128A2 (en) | 2002-02-08 | 2003-02-07 | Autonomous, ambulatory analyte monitor or drug delivery device |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010143116A Division JP2010279704A (ja) | 2002-02-08 | 2010-06-23 | 自律携帯式検体監視装置又は薬剤送給装置 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2005525149A JP2005525149A (ja) | 2005-08-25 |
JP2005525149A5 JP2005525149A5 (ja) | 2006-03-02 |
JP4856849B2 true JP4856849B2 (ja) | 2012-01-18 |
Family
ID=27668042
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003565550A Expired - Lifetime JP4856849B2 (ja) | 2002-02-08 | 2003-02-07 | 自律携帯式検体監視装置又は薬剤送給装置 |
JP2010143116A Pending JP2010279704A (ja) | 2002-02-08 | 2010-06-23 | 自律携帯式検体監視装置又は薬剤送給装置 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010143116A Pending JP2010279704A (ja) | 2002-02-08 | 2010-06-23 | 自律携帯式検体監視装置又は薬剤送給装置 |
Country Status (7)
Country | Link |
---|---|
US (4) | US7004928B2 (ja) |
EP (3) | EP2471570B1 (ja) |
JP (2) | JP4856849B2 (ja) |
AU (1) | AU2003215064A1 (ja) |
CA (1) | CA2476308C (ja) |
DK (1) | DK1480710T3 (ja) |
WO (1) | WO2003066128A2 (ja) |
Families Citing this family (334)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6036924A (en) | 1997-12-04 | 2000-03-14 | Hewlett-Packard Company | Cassette of lancet cartridges for sampling blood |
US6391005B1 (en) | 1998-03-30 | 2002-05-21 | Agilent Technologies, Inc. | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
US6290646B1 (en) | 1999-04-16 | 2001-09-18 | Cardiocom | Apparatus and method for monitoring and communicating wellness parameters of ambulatory patients |
US8419650B2 (en) | 1999-04-16 | 2013-04-16 | Cariocom, LLC | Downloadable datasets for a patient monitoring system |
US8641644B2 (en) | 2000-11-21 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
DE10057832C1 (de) * | 2000-11-21 | 2002-02-21 | Hartmann Paul Ag | Blutanalysegerät |
US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
US8337419B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7025774B2 (en) | 2001-06-12 | 2006-04-11 | Pelikan Technologies, Inc. | Tissue penetration device |
EP1404235A4 (en) | 2001-06-12 | 2008-08-20 | Pelikan Technologies Inc | METHOD AND DEVICE FOR A LANZETTING DEVICE INTEGRATED ON A BLOOD CARTRIDGE CARTRIDGE |
US7981056B2 (en) | 2002-04-19 | 2011-07-19 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
JP4272051B2 (ja) | 2001-06-12 | 2009-06-03 | ペリカン テクノロジーズ インコーポレイテッド | 血液試料採取装置及び方法 |
US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
US7316700B2 (en) | 2001-06-12 | 2008-01-08 | Pelikan Technologies, Inc. | Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties |
DE60238119D1 (de) | 2001-06-12 | 2010-12-09 | Pelikan Technologies Inc | Elektrisches betätigungselement für eine lanzette |
ATE497731T1 (de) | 2001-06-12 | 2011-02-15 | Pelikan Technologies Inc | Gerät zur erhöhung der erfolgsrate im hinblick auf die durch einen fingerstich erhaltene blutausbeute |
US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7004928B2 (en) | 2002-02-08 | 2006-02-28 | Rosedale Medical, Inc. | Autonomous, ambulatory analyte monitor or drug delivery device |
JP3933058B2 (ja) * | 2002-02-25 | 2007-06-20 | 日立化成工業株式会社 | マイクロ流体システム用支持ユニット及びその製造方法 |
US7175642B2 (en) | 2002-04-19 | 2007-02-13 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
US7674232B2 (en) | 2002-04-19 | 2010-03-09 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7491178B2 (en) | 2002-04-19 | 2009-02-17 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7648468B2 (en) | 2002-04-19 | 2010-01-19 | Pelikon Technologies, Inc. | Method and apparatus for penetrating tissue |
US8579831B2 (en) | 2002-04-19 | 2013-11-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7717863B2 (en) | 2002-04-19 | 2010-05-18 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7901362B2 (en) | 2002-04-19 | 2011-03-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7291117B2 (en) | 2002-04-19 | 2007-11-06 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7892183B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
US8784335B2 (en) | 2002-04-19 | 2014-07-22 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling device with a capacitive sensor |
US7909778B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8267870B2 (en) | 2002-04-19 | 2012-09-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling with hybrid actuation |
US7524293B2 (en) * | 2002-04-19 | 2009-04-28 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7226461B2 (en) | 2002-04-19 | 2007-06-05 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with sterility barrier release |
US7297122B2 (en) | 2002-04-19 | 2007-11-20 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
US7232451B2 (en) | 2002-04-19 | 2007-06-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7976476B2 (en) | 2002-04-19 | 2011-07-12 | Pelikan Technologies, Inc. | Device and method for variable speed lancet |
US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7371247B2 (en) | 2002-04-19 | 2008-05-13 | Pelikan Technologies, Inc | Method and apparatus for penetrating tissue |
US7331931B2 (en) | 2002-04-19 | 2008-02-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8372016B2 (en) | 2002-04-19 | 2013-02-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling and analyte sensing |
US7547287B2 (en) * | 2002-04-19 | 2009-06-16 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8221334B2 (en) | 2002-04-19 | 2012-07-17 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US9795334B2 (en) | 2002-04-19 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7229458B2 (en) * | 2002-04-19 | 2007-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8360992B2 (en) | 2002-04-19 | 2013-01-29 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
IES20020794A2 (en) * | 2002-10-04 | 2003-02-19 | Minroc Techn Promotions Ltd | A down-the-hole hammer |
US7544185B2 (en) * | 2002-10-07 | 2009-06-09 | Novo Nordisk A/S | Needle device comprising a plurality of needles |
EP1562470A4 (en) * | 2002-11-01 | 2009-01-14 | Pelikan Technologies Inc | METHOD AND APPARATUS FOR SAMPLING ORGANIC LIQUIDS |
US8574895B2 (en) | 2002-12-30 | 2013-11-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
US7052652B2 (en) * | 2003-03-24 | 2006-05-30 | Rosedale Medical, Inc. | Analyte concentration detection devices and methods |
US7415299B2 (en) * | 2003-04-18 | 2008-08-19 | The Regents Of The University Of California | Monitoring method and/or apparatus |
DE602004028463D1 (de) | 2003-05-30 | 2010-09-16 | Pelikan Technologies Inc | Verfahren und vorrichtung zur injektion von flüssigkeit |
US7850621B2 (en) | 2003-06-06 | 2010-12-14 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
WO2006001797A1 (en) | 2004-06-14 | 2006-01-05 | Pelikan Technologies, Inc. | Low pain penetrating |
EP1663023A4 (en) * | 2003-08-20 | 2010-01-27 | Facet Technologies Llc | AUTOPIQUEUR WITH A MULTI-LANCETTES LOADER |
EP1663025A4 (en) * | 2003-08-20 | 2010-03-24 | Facet Technologies Llc | BLOOD COLLECTION DEVICE |
CN1874720B (zh) * | 2003-09-03 | 2010-11-17 | 生命修复国际股份有限公司 | 个人诊断装置 |
CA2896407A1 (en) * | 2003-09-11 | 2005-03-24 | Theranos, Inc. | Medical device for analyte monitoring and drug delivery |
AU2012213965B2 (en) * | 2003-09-11 | 2015-10-22 | Labrador Diagnostics Llc | Medical device for analyte monitoring and drug delivery |
EP1671096A4 (en) | 2003-09-29 | 2009-09-16 | Pelikan Technologies Inc | METHOD AND APPARATUS FOR PROVIDING IMPROVED SAMPLE CAPTURING DEVICE |
WO2005037095A1 (en) * | 2003-10-14 | 2005-04-28 | Pelikan Technologies, Inc. | Method and apparatus for a variable user interface |
WO2005049107A2 (en) * | 2003-11-18 | 2005-06-02 | Nanapass Technologies Ltd. | Enhanced penetration system and method for sliding microneedles |
US7822454B1 (en) | 2005-01-03 | 2010-10-26 | Pelikan Technologies, Inc. | Fluid sampling device with improved analyte detecting member configuration |
EP1706026B1 (en) | 2003-12-31 | 2017-03-01 | Sanofi-Aventis Deutschland GmbH | Method and apparatus for improving fluidic flow and sample capture |
KR100814545B1 (ko) * | 2004-01-27 | 2008-03-17 | 알티베라, 엘엘씨 | 진단 라디오 주파수 식별 센서 및 그 애플리케이션 |
CN101722065A (zh) * | 2004-02-18 | 2010-06-09 | 日立化成工业株式会社 | 微型流体系统用支撑单元 |
DK1732627T3 (da) | 2004-03-31 | 2010-08-16 | Lilly Co Eli | Injektionsapparat, som har en nålekassette til afgivelse af en farmaceutisk væske |
US8828203B2 (en) | 2004-05-20 | 2014-09-09 | Sanofi-Aventis Deutschland Gmbh | Printable hydrogels for biosensors |
US9775553B2 (en) | 2004-06-03 | 2017-10-03 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
WO2005120365A1 (en) | 2004-06-03 | 2005-12-22 | Pelikan Technologies, Inc. | Method and apparatus for a fluid sampling device |
US7763454B2 (en) * | 2004-07-09 | 2010-07-27 | Church & Dwight Co., Inc. | Electronic analyte assaying device |
US7654956B2 (en) | 2004-07-13 | 2010-02-02 | Dexcom, Inc. | Transcutaneous analyte sensor |
US7512432B2 (en) | 2004-07-27 | 2009-03-31 | Abbott Laboratories | Sensor array |
WO2006015299A2 (en) * | 2004-07-30 | 2006-02-09 | Microchips, Inc. | Multi-reservoir device for transdermal drug delivery and sensing |
US20060030788A1 (en) * | 2004-08-04 | 2006-02-09 | Daniel Wong | Apparatus and method for extracting bodily fluid utilizing a flat lancet |
EP2289646B1 (en) | 2004-08-16 | 2014-02-12 | Functional Microstructures Limited | Device to be applied to a biological barrier |
US7604604B2 (en) * | 2004-09-09 | 2009-10-20 | Roche Diagnostics Operations, Inc. | Device for sampling bodily fluids |
US7645241B2 (en) * | 2004-09-09 | 2010-01-12 | Roche Diagnostics Operations, Inc. | Device for sampling bodily fluids |
US8252321B2 (en) | 2004-09-13 | 2012-08-28 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like |
GB0420256D0 (en) | 2004-09-13 | 2004-10-13 | Cassells John M | Method and apparatus for sampling and analysis of fluids |
US7780981B2 (en) | 2004-09-13 | 2010-08-24 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery |
US7510528B2 (en) * | 2004-09-16 | 2009-03-31 | Shai Shlomo Jaffe | Device and method for noninvasive measuring glucose level in the blood |
US7608042B2 (en) * | 2004-09-29 | 2009-10-27 | Intellidx, Inc. | Blood monitoring system |
US20060229531A1 (en) * | 2005-02-01 | 2006-10-12 | Daniel Goldberger | Blood monitoring system |
US20070191716A1 (en) * | 2004-09-29 | 2007-08-16 | Daniel Goldberger | Blood monitoring system |
US20060074294A1 (en) * | 2004-10-06 | 2006-04-06 | E-Z-Em, Inc. | Medical imaging system, dispensing system, method, and computer program product for assessing patient renal function prior to dispensing a contrast media as part of a medical imaging procedure |
US8267889B2 (en) | 2004-11-18 | 2012-09-18 | 3M Innovative Properties Company | Low-profile microneedle array applicator |
WO2006054280A2 (en) * | 2004-11-18 | 2006-05-26 | Nanopass Technologies Ltd. | System and method for delivering fluid into flexible biological barrier |
US20080009801A1 (en) * | 2004-12-02 | 2008-01-10 | Nickel Janice H | Method for dispensing material into a drug delivery device |
US8652831B2 (en) | 2004-12-30 | 2014-02-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte measurement test time |
US8280476B2 (en) | 2005-03-29 | 2012-10-02 | Arkal Medical, Inc. | Devices, systems, methods and tools for continuous glucose monitoring |
ATE555824T1 (de) | 2005-04-11 | 2012-05-15 | Infotonics Technology Ct Inc | Blutüberwachungssysteme und verfahren dafür |
US7569050B2 (en) | 2005-05-06 | 2009-08-04 | Medtronic Minimed, Inc. | Infusion device and method with drive device in infusion device and method with drive device in separable durable housing portion |
KR101569307B1 (ko) | 2005-05-09 | 2015-11-13 | 테라노스, 인코포레이티드 | 현장진료 유체 시스템 및 그 용도 |
US20060281187A1 (en) * | 2005-06-13 | 2006-12-14 | Rosedale Medical, Inc. | Analyte detection devices and methods with hematocrit/volume correction and feedback control |
US20060283465A1 (en) * | 2005-06-16 | 2006-12-21 | Nickel Janice H | Smart drug delivery system and a method of implementation thereof |
US8784363B2 (en) * | 2005-06-27 | 2014-07-22 | 3M Innovative Properties Company | Microneedle array applicator device and method of array application |
US20070073590A1 (en) * | 2005-08-22 | 2007-03-29 | Cosentino Louis C | Remote monitor for physiological parameters and durable medical supplies |
US7887494B2 (en) * | 2005-09-30 | 2011-02-15 | Intuity Medical, Inc. | Fluid sample transport devices and methods |
EP3461406A1 (en) * | 2005-09-30 | 2019-04-03 | Intuity Medical, Inc. | Multi-site body fluid sampling and analysis cartridge |
US8801631B2 (en) | 2005-09-30 | 2014-08-12 | Intuity Medical, Inc. | Devices and methods for facilitating fluid transport |
WO2007054317A1 (en) * | 2005-11-09 | 2007-05-18 | Medizinische Universität Graz | Determining a value of a physiological parameter |
US20070119710A1 (en) * | 2005-11-28 | 2007-05-31 | Daniel Goldberger | Test substrate handling apparatus |
US20080200838A1 (en) * | 2005-11-28 | 2008-08-21 | Daniel Goldberger | Wearable, programmable automated blood testing system |
US20070123801A1 (en) * | 2005-11-28 | 2007-05-31 | Daniel Goldberger | Wearable, programmable automated blood testing system |
US7922971B2 (en) * | 2005-11-30 | 2011-04-12 | Abbott Diabetes Care Inc. | Integrated meter for analyzing biological samples |
US8815175B2 (en) * | 2005-11-30 | 2014-08-26 | Abbott Diabetes Care Inc. | Integrated meter for analyzing biological samples |
US8105244B2 (en) * | 2005-11-30 | 2012-01-31 | Abbott Diabetes Care Inc. | Integrated sensor for analyzing biological samples |
WO2007093981A2 (en) * | 2006-02-15 | 2007-08-23 | Medingo Ltd. | Systems and methods for sensing analyte and dispensing therapeutic fluid |
DK4282332T3 (da) | 2006-02-22 | 2024-06-24 | Dexcom Inc | Analytsensor |
GB0605003D0 (en) * | 2006-03-13 | 2006-04-19 | Microsample Ltd | Method and apparatus for piercing the skin and delivery or collection of liquids |
US11287421B2 (en) | 2006-03-24 | 2022-03-29 | Labrador Diagnostics Llc | Systems and methods of sample processing and fluid control in a fluidic system |
US8741230B2 (en) | 2006-03-24 | 2014-06-03 | Theranos, Inc. | Systems and methods of sample processing and fluid control in a fluidic system |
US9119945B2 (en) * | 2006-04-20 | 2015-09-01 | 3M Innovative Properties Company | Device for applying a microneedle array |
US8007999B2 (en) | 2006-05-10 | 2011-08-30 | Theranos, Inc. | Real-time detection of influenza virus |
US8092385B2 (en) | 2006-05-23 | 2012-01-10 | Intellidx, Inc. | Fluid access interface |
US20070276211A1 (en) * | 2006-05-26 | 2007-11-29 | Jose Mir | Compact minimally invasive biomedical monitor |
US9308325B2 (en) * | 2006-06-19 | 2016-04-12 | Corium International, Inc. | Methods, devices, and kits for microjet drug delivery |
US9119582B2 (en) | 2006-06-30 | 2015-09-01 | Abbott Diabetes Care, Inc. | Integrated analyte sensor and infusion device and methods therefor |
WO2008004781A1 (en) * | 2006-07-03 | 2008-01-10 | Honam Petrochemical Corp. | Micro neddle roller assembly |
WO2008149333A1 (en) * | 2006-07-06 | 2008-12-11 | Rapidx Ltd | Intergrated blood sampling and testing device and method of use thereof |
CN101528830A (zh) | 2006-07-10 | 2009-09-09 | 麦德医像公司 | 超弹性环氧水凝胶 |
US20100100005A1 (en) * | 2006-07-11 | 2010-04-22 | Infotonics Technology Center, Inc. | Minimally invasive allergy testing system with coated allergens |
WO2008008557A1 (en) * | 2006-07-11 | 2008-01-17 | Infotonics Technology Center, Inc. | Allergy testing cartridge with coated allergens |
WO2008008008A1 (en) * | 2006-07-13 | 2008-01-17 | St. Jude Medical Ab | Information management in devices worn by a use |
US8372015B2 (en) * | 2006-08-28 | 2013-02-12 | Intuity Medical, Inc. | Body fluid sampling device with pivotable catalyst member |
US20080058726A1 (en) * | 2006-08-30 | 2008-03-06 | Arvind Jina | Methods and Apparatus Incorporating a Surface Penetration Device |
US8012744B2 (en) | 2006-10-13 | 2011-09-06 | Theranos, Inc. | Reducing optical interference in a fluidic device |
US20080113391A1 (en) | 2006-11-14 | 2008-05-15 | Ian Gibbons | Detection and quantification of analytes in bodily fluids |
WO2008080990A1 (de) | 2006-12-29 | 2008-07-10 | Disetronic Licensing Ag | Extrakorporal tragbare infusionsvorrichtung |
US8560059B2 (en) * | 2007-03-09 | 2013-10-15 | Covidien Lp | System and methods for optical sensing and drug delivery using microneedles |
US7713196B2 (en) | 2007-03-09 | 2010-05-11 | Nellcor Puritan Bennett Llc | Method for evaluating skin hydration and fluid compartmentalization |
US20080228056A1 (en) | 2007-03-13 | 2008-09-18 | Michael Blomquist | Basal rate testing using frequent blood glucose input |
US8456301B2 (en) | 2007-05-08 | 2013-06-04 | Abbott Diabetes Care Inc. | Analyte monitoring system and methods |
US7751907B2 (en) | 2007-05-24 | 2010-07-06 | Smiths Medical Asd, Inc. | Expert system for insulin pump therapy |
ATE534328T1 (de) * | 2007-05-29 | 2011-12-15 | Hoffmann La Roche | Flexible lanzette in einem lanzettensystem |
US8221345B2 (en) | 2007-05-30 | 2012-07-17 | Smiths Medical Asd, Inc. | Insulin pump based expert system |
US20100152660A1 (en) * | 2007-05-30 | 2010-06-17 | Eli Lilly And Company | Cartridge with multiple injection needles for a medication injection device |
KR100819468B1 (ko) * | 2007-05-31 | 2008-04-08 | (주)엠큐어 | 멀티 인젝션이 가능한 멀티홀 시술 장치 |
US8197650B2 (en) * | 2007-06-07 | 2012-06-12 | Sensor Innovations, Inc. | Silicon electrochemical sensors |
WO2008154416A2 (en) * | 2007-06-07 | 2008-12-18 | Microchips, Inc. | Electrochemical biosensors and arrays |
DE102007026752A1 (de) * | 2007-06-09 | 2008-12-11 | Ivonne Silvester | Vorrichtung zur Aufbewahrung und Applikation von Wirkstoffen |
US20080312518A1 (en) * | 2007-06-14 | 2008-12-18 | Arkal Medical, Inc | On-demand analyte monitor and method of use |
US8160900B2 (en) | 2007-06-29 | 2012-04-17 | Abbott Diabetes Care Inc. | Analyte monitoring and management device and method to analyze the frequency of user interaction with the device |
US9993619B2 (en) | 2007-07-17 | 2018-06-12 | C. R. Bard, Inc. | Securement system for a medical article |
US8158430B1 (en) | 2007-08-06 | 2012-04-17 | Theranos, Inc. | Systems and methods of fluidic sample processing |
US8328720B2 (en) * | 2007-08-10 | 2012-12-11 | Infotonics Technology Center, Inc. | MEMS interstitial prothrombin time test |
US11154698B2 (en) * | 2007-08-24 | 2021-10-26 | Deka Products Limited Partnership | Microneedle systems and apparatus |
EP2030567A1 (de) * | 2007-08-31 | 2009-03-04 | Roche Diagnostics GmbH | Analysegerät zur Bestimmung eines Analyten in einer Körperflüssigkeit, Magazin für ein Analysegerät und Verfahren zur Erzeugung einer Wunde und zum Untersuchen einer austretenden Körperflüssigkeit |
US8961431B2 (en) * | 2009-09-28 | 2015-02-24 | Roche Diagnostics Operations, Inc. | Body fluid lancing, acquiring, and testing cartridge design |
US9186097B2 (en) * | 2007-09-17 | 2015-11-17 | Roche Diabetes Care, Inc. | Body fluid lancing, acquiring, and testing cartridge design |
US8192360B2 (en) * | 2007-09-25 | 2012-06-05 | Pacesetter, Inc. | Implantable body fluid analyzer |
CA3170924A1 (en) | 2007-10-02 | 2009-04-09 | Labrador Diagnostics Llc | Modular point-of-care devices and uses thereof |
EP2050392B1 (de) * | 2007-10-15 | 2012-09-05 | Roche Diagnostics GmbH | Lanzettenrad |
US20090188811A1 (en) | 2007-11-28 | 2009-07-30 | Edwards Lifesciences Corporation | Preparation and maintenance of sensors |
WO2009073734A2 (en) | 2007-12-03 | 2009-06-11 | Medipacs, Inc. | Fluid metering device |
GB0724402D0 (en) * | 2007-12-14 | 2008-01-30 | Univ Leiden | Microneedle injecting apparatus and method |
CN101970030B (zh) * | 2007-12-17 | 2014-04-16 | 新世界药品有限公司 | 整合的真皮内递送、诊断和通讯系统 |
WO2009081405A2 (en) | 2007-12-25 | 2009-07-02 | Rapidx Ltd. | Devices and methods for reduced-pain blood sampling |
US20090177147A1 (en) | 2008-01-07 | 2009-07-09 | Michael Blomquist | Insulin pump with insulin therapy coaching |
US20090177142A1 (en) | 2008-01-09 | 2009-07-09 | Smiths Medical Md, Inc | Insulin pump with add-on modules |
US20090209883A1 (en) * | 2008-01-17 | 2009-08-20 | Michael Higgins | Tissue penetrating apparatus |
US8986253B2 (en) | 2008-01-25 | 2015-03-24 | Tandem Diabetes Care, Inc. | Two chamber pumps and related methods |
KR20110004845A (ko) * | 2008-02-27 | 2011-01-14 | 엠오엔4디 엘티디 | 모듈식 분석물 모니터링 장치, 시스템 및 방법 |
JP5348707B2 (ja) * | 2008-02-27 | 2013-11-20 | モン4ディー リミテッド | モジュールの検体モニタのための装置、システム及び方法 |
EP2265324B1 (en) | 2008-04-11 | 2015-01-28 | Sanofi-Aventis Deutschland GmbH | Integrated analyte measurement system |
US20090264720A1 (en) * | 2008-04-17 | 2009-10-22 | The Cooper Health System | Wearable Automated Blood Sampling and Monitoring System |
US8133197B2 (en) | 2008-05-02 | 2012-03-13 | Smiths Medical Asd, Inc. | Display for pump |
EP2113197A1 (de) * | 2008-05-03 | 2009-11-04 | Roche Diagnostics GmbH | Lanzettenrad und Verfahren zur Herstellung eines Lanzettenrades |
JP5816080B2 (ja) | 2008-05-30 | 2015-11-17 | インテュイティ メディカル インコーポレイテッド | 体液採取装置及び採取部位インターフェイス |
JP5642066B2 (ja) | 2008-06-06 | 2014-12-17 | インテュイティ メディカル インコーポレイテッド | 体液の試料内に含まれている検体の存在または濃度を決定する検定を行う方法および装置 |
EP2299904B1 (en) | 2008-06-06 | 2019-09-11 | Intuity Medical, Inc. | Medical measurement method |
JP5798918B2 (ja) * | 2008-08-21 | 2015-10-21 | ナインポイント メディカル, インコーポレイテッド | 薬物評価および局所処置のためのデバイスおよび方法 |
US8408421B2 (en) | 2008-09-16 | 2013-04-02 | Tandem Diabetes Care, Inc. | Flow regulating stopcocks and related methods |
WO2010033878A2 (en) | 2008-09-19 | 2010-03-25 | David Brown | Solute concentration measurement device and related methods |
US8333715B1 (en) | 2008-10-07 | 2012-12-18 | Alferness Clifton A | Blood glucose sampling device |
US8597570B2 (en) | 2008-11-04 | 2013-12-03 | Panasonic Corporation | Measurement device, insulin infusion device, measurement method, method for controlling insulin infusion device, and program |
HUE049678T2 (hu) | 2008-12-02 | 2020-10-28 | Allergan Inc | Injekciós eszköz |
EP3763403A1 (en) | 2009-01-12 | 2021-01-13 | Becton, Dickinson and Company | Infusion set and/or patch pump having a flexible catheter attachment |
US9375529B2 (en) | 2009-09-02 | 2016-06-28 | Becton, Dickinson And Company | Extended use medical device |
DK2391892T3 (en) | 2009-01-30 | 2017-04-24 | Mycartis N V | BIOMARKET FOR DIAGNOSIS, PREDICTION AND / OR PROJECTS OF ACUTE HEART FAILURE AND USE thereof |
US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
US20100198034A1 (en) | 2009-02-03 | 2010-08-05 | Abbott Diabetes Care Inc. | Compact On-Body Physiological Monitoring Devices and Methods Thereof |
WO2010094427A2 (de) * | 2009-02-19 | 2010-08-26 | Roche Diagnostics Gmbh | Platzsparende magazinierung analytischer hilfsmittel |
EP2226007A1 (de) | 2009-02-19 | 2010-09-08 | Roche Diagnostics GmbH | Testelementmagazin mit abgedeckten Testfeldern |
EP2226008A1 (de) | 2009-02-19 | 2010-09-08 | Roche Diagnostics GmbH | Verfahren zur Herstellung eines analytischen Magazins |
US20110105952A1 (en) * | 2009-10-30 | 2011-05-05 | Seventh Sense Biosystems, Inc. | Relatively small devices applied to the skin, modular systems, and methods of use thereof |
US20110172508A1 (en) * | 2010-01-13 | 2011-07-14 | Seventh Sense Biosystems, Inc. | Sampling device interfaces |
WO2012021792A2 (en) * | 2010-08-13 | 2012-02-16 | Seventh Sense Biosystems, Inc. | Clinical and/or consumer techniques and devices |
WO2010101626A1 (en) | 2009-03-02 | 2010-09-10 | Seventh Sense Biosystems, Inc. | Techniques and devices associated with blood sampling |
US8753290B2 (en) * | 2009-03-27 | 2014-06-17 | Intellectual Inspiration, Llc | Fluid transfer system and method |
US20100249652A1 (en) * | 2009-03-31 | 2010-09-30 | Abbott Diabetes Care Inc. | Integrated Analyte Devices and Processes |
JP2010233803A (ja) * | 2009-03-31 | 2010-10-21 | Sysmex Corp | 微細孔形成用穿刺装置 |
EP2260898A1 (en) * | 2009-06-10 | 2010-12-15 | Ulrich Schäfer | Guide wire and method for its use |
US8939928B2 (en) | 2009-07-23 | 2015-01-27 | Becton, Dickinson And Company | Medical device having capacitive coupling communication and energy harvesting |
WO2011014704A2 (en) | 2009-07-30 | 2011-02-03 | Tandem Diabetes Care, Inc. | Infusion pump system with disposable cartridge having pressure venting and pressure feedback |
EP2470256A4 (en) * | 2009-09-01 | 2015-05-27 | Univ Virginia Patent Found | SYSTEM, METHOD AND COMPUTER PROGRAM PRODUCT FOR ADJUSTING INSULIN DELIVERY (AID) IN THE TREATMENT OF DIABETES USING OPEN LOOP NOMINAL PROFILES |
US10092691B2 (en) | 2009-09-02 | 2018-10-09 | Becton, Dickinson And Company | Flexible and conformal patch pump |
US20110319742A1 (en) * | 2009-09-08 | 2011-12-29 | SensiVida Medical Technologies, Inc. | Spatial imaging methods for biomedical monitoring and systems thereof |
WO2011032011A1 (en) | 2009-09-10 | 2011-03-17 | Medipacs, Inc. | Low profile actuator and improved method of caregiver controlled administration of therapeutics |
US8734890B2 (en) * | 2009-09-16 | 2014-05-27 | National Tsing Hua University | Method for forming a molecularly imprinted polymer biosensor |
ES2393025B1 (es) * | 2009-09-23 | 2013-10-23 | Universidad De Alicante | Sistema de extracción de muestras sanguíneas de seguridad. |
WO2011044256A1 (en) * | 2009-10-06 | 2011-04-14 | Venetec International, Inc. | Medical securement device with timer |
CA2776239C (en) | 2009-10-06 | 2018-06-05 | Venetec International, Inc. | Stabilizing device having a snap clamp |
KR20180078345A (ko) | 2009-10-19 | 2018-07-09 | 테라노스, 인코포레이티드 | 통합형 건강 정보 취득 및 분석 시스템 |
WO2011048168A1 (en) | 2009-10-21 | 2011-04-28 | Pronota N.V. | Biomarker for diagnosis, prediction and/or prognosis of acute heart failure and uses thereof |
EP2493537B1 (en) * | 2009-10-30 | 2017-12-06 | Seventh Sense Biosystems, Inc. | Systems and methods for treating, sanitizing, and/or shielding the skin or devices applied to the skin |
EP2493535A2 (en) * | 2009-10-30 | 2012-09-05 | Seventh Sense Biosystems, Inc. | Systems and methods for application to skin and control of actuation, delivery and/or perception thereof |
WO2011065972A2 (en) * | 2009-11-24 | 2011-06-03 | Seventh Sense Biosystems, Inc. | Patient-enacted sampling technique |
EP2506768B1 (en) | 2009-11-30 | 2016-07-06 | Intuity Medical, Inc. | Calibration material delivery devices and methods |
US8882701B2 (en) | 2009-12-04 | 2014-11-11 | Smiths Medical Asd, Inc. | Advanced step therapy delivery for an ambulatory infusion pump and system |
US20110172639A1 (en) * | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Device and method for delivery of microneedle to desired depth within the skin |
US20110172609A1 (en) * | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Microneedle component assembly for drug delivery device |
US20110172637A1 (en) * | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Drug delivery device including tissue support structure |
US20110172645A1 (en) * | 2010-01-08 | 2011-07-14 | Ratio, Inc. | Wearable drug delivery device including integrated pumping and activation elements |
CN102811754B (zh) * | 2010-01-13 | 2017-05-17 | 第七感生物系统有限公司 | 流体的快速输送和/或抽出 |
WO2011094573A1 (en) * | 2010-01-28 | 2011-08-04 | Seventh Sense Biosystems, Inc. | Monitoring or feedback systems and methods |
US9500186B2 (en) | 2010-02-01 | 2016-11-22 | Medipacs, Inc. | High surface area polymer actuator with gas mitigating components |
WO2011116388A1 (en) * | 2010-03-19 | 2011-09-22 | Nanostar Health Corporation | Body fluid sampling/fluid delivery device |
US9265453B2 (en) | 2010-03-24 | 2016-02-23 | Abbott Diabetes Care Inc. | Medical device inserters and processes of inserting and using medical devices |
CA2788760A1 (en) | 2010-03-26 | 2011-09-29 | Pronota N.V. | Ltbp2 as a biomarker for renal dysfunction |
WO2011128357A2 (en) | 2010-04-13 | 2011-10-20 | Pronota N.V. | Biomarkers for hypertensive disorders of pregnancy |
US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
WO2011163347A2 (en) | 2010-06-23 | 2011-12-29 | Seventh Sense Biosystems, Inc. | Sampling devices and methods involving relatively little pain |
US10330667B2 (en) | 2010-06-25 | 2019-06-25 | Intuity Medical, Inc. | Analyte monitoring methods and systems |
JP2013538069A (ja) | 2010-07-16 | 2013-10-10 | セブンス センス バイオシステムズ,インコーポレーテッド | 流体移動デバイスのための低圧環境 |
US20130158482A1 (en) | 2010-07-26 | 2013-06-20 | Seventh Sense Biosystems, Inc. | Rapid delivery and/or receiving of fluids |
WO2012021801A2 (en) | 2010-08-13 | 2012-02-16 | Seventh Sense Biosystems, Inc. | Systems and techniques for monitoring subjects |
US8668675B2 (en) | 2010-11-03 | 2014-03-11 | Flugen, Inc. | Wearable drug delivery device having spring drive and sliding actuation mechanism |
US9017289B2 (en) | 2010-11-03 | 2015-04-28 | Covidien Lp | Transdermal fluid delivery device |
EP2992827B1 (en) | 2010-11-09 | 2017-04-19 | Seventh Sense Biosystems, Inc. | Systems and interfaces for blood sampling |
WO2012068321A1 (en) | 2010-11-19 | 2012-05-24 | Eli Lilly And Company | Needle magazine for medication injection device |
US9950109B2 (en) | 2010-11-30 | 2018-04-24 | Becton, Dickinson And Company | Slide-activated angled inserter and cantilevered ballistic insertion for intradermal drug infusion |
US8814831B2 (en) | 2010-11-30 | 2014-08-26 | Becton, Dickinson And Company | Ballistic microneedle infusion device |
US8795230B2 (en) | 2010-11-30 | 2014-08-05 | Becton, Dickinson And Company | Adjustable height needle infusion device |
WO2012083258A2 (en) | 2010-12-16 | 2012-06-21 | Sensor Innovations, Inc. | Electrochemical sensors |
US8852123B2 (en) | 2010-12-30 | 2014-10-07 | Roche Diagnostics Operations, Inc. | Handheld medical diagnostic devices housing with sample transfer |
US9717452B2 (en) | 2010-12-30 | 2017-08-01 | Roche Diabetes Care, Inc. | Handheld medical diagnostic devices with lancing speed control |
US8158428B1 (en) | 2010-12-30 | 2012-04-17 | General Electric Company | Methods, systems and apparatus for detecting material defects in combustors of combustion turbine engines |
CN106290160A (zh) | 2011-01-21 | 2017-01-04 | 提拉诺斯公司 | 样品使用最大化的系统和方法 |
EP2685898B1 (en) | 2011-03-18 | 2022-09-07 | Sanofi-Aventis Deutschland GmbH | Calculating a medicament dose |
US10244981B2 (en) | 2011-03-30 | 2019-04-02 | SensiVida Medical Technologies, Inc. | Skin test image analysis apparatuses and methods thereof |
WO2012145683A1 (en) | 2011-04-21 | 2012-10-26 | Venetec International, Inc. | Anchoring system |
EP2701598A1 (en) | 2011-04-29 | 2014-03-05 | Seventh Sense Biosystems, Inc. | Systems and methods for collecting fluid from a subject |
US20130158468A1 (en) | 2011-12-19 | 2013-06-20 | Seventh Sense Biosystems, Inc. | Delivering and/or receiving material with respect to a subject surface |
EP2701600B1 (en) | 2011-04-29 | 2016-06-08 | Seventh Sense Biosystems, Inc. | Delivering and/or receiving fluids |
AU2012249683A1 (en) | 2011-04-29 | 2013-11-14 | Seventh Sense Biosystems, Inc. | Devices and methods for collection and/or manipulation of blood spots or other bodily fluids |
CN103608682B (zh) * | 2011-05-05 | 2017-01-18 | 安派科生物医学科技有限公司 | 肿瘤细胞检测仪 |
US20120330188A1 (en) | 2011-06-21 | 2012-12-27 | Gadlight, Inc. | Cocking and Advancing Mechanism for Analyte Testing Device |
US20130085349A1 (en) | 2011-06-21 | 2013-04-04 | Yofimeter, Llc | Analyte testing devices |
US8333716B1 (en) | 2011-06-21 | 2012-12-18 | Yofimeter, Llc | Methods for using an analyte testing device |
EP2729148A4 (en) | 2011-07-06 | 2015-04-22 | Parkinson S Inst | COMPOSITIONS AND METHODS FOR TREATING SYMPTOMS IN PATIENTS WITH PARKINSON'S DISEASE |
GB2493176A (en) * | 2011-07-27 | 2013-01-30 | Ocelus Ltd | Microneedle device |
CA2843945C (en) * | 2011-08-03 | 2022-06-21 | Intuity Medical, Inc. | Devices and methods for body fluid sampling and analysis |
US10010707B2 (en) | 2011-10-12 | 2018-07-03 | 3M Innovative Properties Company | Integrated microneedle array delivery system |
DE102011056273B4 (de) * | 2011-12-12 | 2013-11-21 | sense2care GmbH | Fluidreservoir für eine Vorrichtung zur Analyse von Patientenproben |
EP2604304A1 (en) * | 2011-12-14 | 2013-06-19 | Sanofi-Aventis Deutschland GmbH | Needle storage magazine |
WO2013090731A1 (en) * | 2011-12-15 | 2013-06-20 | Becton, Dickinson And Company | System for improved interpretation of physiological data and presentation of physiological condition management information |
WO2013101908A1 (en) * | 2011-12-27 | 2013-07-04 | Massachusetts Institute Of Technology | Microneedle devices and uses thereof |
US20150005595A1 (en) | 2011-12-30 | 2015-01-01 | Kibur Medical, Inc. | Implantable devices and methods for evaluation of active agents |
EP2797582B1 (en) | 2011-12-30 | 2019-03-13 | Kibur Medical, Inc. | Implantable devices and methods for the evaluation of active agent |
EP2825500B1 (en) * | 2012-03-13 | 2016-01-06 | Becton Dickinson France | Method of manufacture for a miniaturized drug delivery device |
JP2015510956A (ja) | 2012-03-14 | 2015-04-13 | メディパックス インコーポレイテッド | 過剰反応性分子を含むスマートポリマー材料 |
JP5653469B2 (ja) * | 2012-03-30 | 2015-01-14 | アークレイ株式会社 | 測定装置および測定システム |
KR101483988B1 (ko) * | 2012-04-09 | 2015-01-28 | 연세대학교 산학협력단 | 망막하 주사 또는 추출용 중공형 마이크로니들 및 망막하 주사기 |
US9180242B2 (en) | 2012-05-17 | 2015-11-10 | Tandem Diabetes Care, Inc. | Methods and devices for multiple fluid transfer |
US9555186B2 (en) | 2012-06-05 | 2017-01-31 | Tandem Diabetes Care, Inc. | Infusion pump system with disposable cartridge having pressure venting and pressure feedback |
US9238100B2 (en) | 2012-06-07 | 2016-01-19 | Tandem Diabetes Care, Inc. | Device and method for training users of ambulatory medical devices |
EP2872056B1 (en) | 2012-07-10 | 2020-09-16 | Becton Dickinson France S.A.S | Integrated injection system and communication device |
US20170296317A1 (en) * | 2012-08-13 | 2017-10-19 | Tg Medwise Ltd. | Substance delivery device |
US9675284B2 (en) | 2012-11-01 | 2017-06-13 | David R. Elmaleh | Apparatus and method for detecting and\or monitoring one or more compounds in blood |
US9395234B2 (en) | 2012-12-05 | 2016-07-19 | Cardiocom, Llc | Stabilizing base for scale |
EP2866660B1 (en) * | 2012-12-07 | 2015-10-21 | Ascilion AB | A microfabricated sensor and a method of sensing the level of a component in bodily fluid |
US10105487B2 (en) | 2013-01-24 | 2018-10-23 | Chrono Therapeutics Inc. | Optimized bio-synchronous bioactive agent delivery system |
US10357606B2 (en) | 2013-03-13 | 2019-07-23 | Tandem Diabetes Care, Inc. | System and method for integration of insulin pumps and continuous glucose monitoring |
US9173998B2 (en) | 2013-03-14 | 2015-11-03 | Tandem Diabetes Care, Inc. | System and method for detecting occlusions in an infusion pump |
US9445445B2 (en) | 2013-03-14 | 2016-09-13 | Dexcom, Inc. | Systems and methods for processing and transmitting sensor data |
US10016561B2 (en) | 2013-03-15 | 2018-07-10 | Tandem Diabetes Care, Inc. | Clinical variable determination |
US9486171B2 (en) | 2013-03-15 | 2016-11-08 | Tandem Diabetes Care, Inc. | Predictive calibration |
WO2014160804A2 (en) * | 2013-03-26 | 2014-10-02 | The Trustees Of Columbia University In The City Of New York | Fluid extraction and drug delivery system and methods using microneedles |
US20140350518A1 (en) | 2013-05-23 | 2014-11-27 | Allergan, Inc. | Syringe extrusion accessory |
US20140350516A1 (en) | 2013-05-23 | 2014-11-27 | Allergan, Inc. | Mechanical syringe accessory |
JP2016522070A (ja) | 2013-06-21 | 2016-07-28 | インテュイティ メディカル インコーポレイテッド | 可聴フィードバックを用いた分析物モニタリングシステム |
US20160151010A1 (en) | 2013-07-17 | 2016-06-02 | Glucocheck Ltd. | Blood sampling device and methods |
WO2015009970A1 (en) | 2013-07-18 | 2015-01-22 | Erythron Llc | Spectroscopic measurements with parallel array detector |
FR3008602A1 (fr) | 2013-07-19 | 2015-01-23 | Lape Medical | Dispositif de surveillance sous forme de patch |
CN105705944A (zh) * | 2013-09-08 | 2016-06-22 | 赛拉诺斯股份有限公司 | 用于获得临床样品的方法和系统 |
WO2015131151A2 (en) | 2014-02-28 | 2015-09-03 | Erythron, Llc | Method and apparatus for determining markers of health by analysis of blood |
WO2015134975A1 (en) * | 2014-03-07 | 2015-09-11 | Eldeen, Inc. | Systems and apparatus for needle-penetration pain management |
US10004845B2 (en) | 2014-04-18 | 2018-06-26 | Becton, Dickinson And Company | Split piston metering pump |
US10029048B2 (en) | 2014-05-13 | 2018-07-24 | Allergan, Inc. | High force injection devices |
IL281354B2 (en) * | 2014-06-03 | 2024-06-01 | Amgen Inc | Devices and methods to assist the user of a drug delivery device |
US9416775B2 (en) | 2014-07-02 | 2016-08-16 | Becton, Dickinson And Company | Internal cam metering pump |
EP3174577A4 (en) | 2014-07-30 | 2018-04-18 | Tandem Diabetes Care, Inc. | Temporary suspension for closed-loop medicament therapy |
US10321858B2 (en) | 2014-08-18 | 2019-06-18 | Proteadx, Inc. | Apparatus and methods for transdermal sensing of analytes in interstitial fluid and associated data transmission systems |
US10226585B2 (en) | 2014-10-01 | 2019-03-12 | Allergan, Inc. | Devices for injection and dosing |
WO2016065190A1 (en) | 2014-10-23 | 2016-04-28 | Abbott Diabetes Care Inc. | Electrodes having at least one sensing structure and methods for making and using the same |
AU2016211330A1 (en) | 2015-01-28 | 2017-08-03 | Chrono Therapeutics Inc. | Drug delivery methods and systems |
CN107635527B (zh) | 2015-03-10 | 2021-04-23 | 里珍纳龙药品有限公司 | 无菌刺穿系统和方法 |
CA2976544A1 (en) | 2015-03-10 | 2016-09-15 | Allergan Pharmaceuticals Holdings (Ireland) Unlimited Company | Multiple needle injector |
AU2016228779A1 (en) | 2015-03-12 | 2017-09-07 | Chrono Therapeutics Inc. | Craving input and support system |
EP3282937A4 (en) | 2015-04-14 | 2018-11-21 | Nueon Inc. | Method and apparatus for determining markers of health by analysis of blood |
WO2017100480A1 (en) * | 2015-12-08 | 2017-06-15 | Elmaleh David R | Apparatus and method for detecting and/or monitoring one or more compounds in blood |
US10569016B2 (en) | 2015-12-29 | 2020-02-25 | Tandem Diabetes Care, Inc. | System and method for switching between closed loop and open loop control of an ambulatory infusion pump |
CN108778248A (zh) | 2016-02-19 | 2018-11-09 | 北卡罗来纳州立大学 | 与生理响应性微针递送系统有关的方法和组合物 |
WO2017165403A1 (en) | 2016-03-21 | 2017-09-28 | Nueon Inc. | Porous mesh spectrometry methods and apparatus |
CN109310827B (zh) | 2016-04-08 | 2021-09-07 | 阿勒根公司 | 抽吸和注射装置 |
US11369314B2 (en) | 2016-07-18 | 2022-06-28 | Siemens Healthcare Diagnostics Inc. | Biofouling prevention of wearable sensors and methods of use and calibration related thereto |
US10994077B2 (en) | 2016-07-21 | 2021-05-04 | Tandem Diabetes Care, Inc. | Enhanced confirmations for touchscreen infusion pump |
EP3500857B1 (en) | 2016-08-22 | 2023-10-04 | Ramot at Tel-Aviv University Ltd. | Methods and systems for detecting bioanalytes |
WO2018085699A1 (en) | 2016-11-04 | 2018-05-11 | Nueon Inc. | Combination blood lancet and analyzer |
WO2018106723A1 (en) * | 2016-12-05 | 2018-06-14 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
JP2020503950A (ja) | 2017-01-06 | 2020-02-06 | クロノ セラピューティクス インコーポレイテッドChrono Therapeutics Inc. | 経皮薬剤送達の装置及び方法 |
USD867582S1 (en) | 2017-03-24 | 2019-11-19 | Allergan, Inc. | Syringe device |
MX2019012670A (es) | 2017-05-05 | 2020-07-13 | Regeneron Pharma | Autoinyector. |
CN111803084A (zh) * | 2017-06-02 | 2020-10-23 | 西北大学 | 用于表皮采样和感测的微流体系统 |
CN107669251A (zh) * | 2017-11-08 | 2018-02-09 | 何庆 | 一种心跳呼吸监测方法和监测手环 |
JP7420797B2 (ja) | 2018-05-29 | 2024-01-23 | モーニングサイド ベンチャー インベストメンツ リミテッド | 薬剤送達の方法及びシステム |
EP3603512A1 (fr) * | 2018-08-03 | 2020-02-05 | PKvitality | Patch adhésif bi-rigidité |
US11423281B2 (en) * | 2019-02-01 | 2022-08-23 | International Business Machines Corporation | Personalized activity adviser model |
JP6850457B2 (ja) * | 2019-03-12 | 2021-03-31 | シンクランド株式会社 | 角質層採取方法 |
CN113727747A (zh) * | 2019-03-25 | 2021-11-30 | 比奥林公司 | 用于将微针阵列分析物选择性传感器结合到输液器、贴片泵或自动治疗递送系统中的设备和方法 |
US11590332B2 (en) * | 2019-04-17 | 2023-02-28 | Path Scientific, Llc | Precision microneedling device and methods of use |
GB201908043D0 (en) * | 2019-06-05 | 2019-07-17 | Lekkos Vasileios | Transdermal patch for therapeutic uses |
IL293989A (en) * | 2019-12-20 | 2022-08-01 | Ares Trading Sa | A device for delivering a bioactive substance through the skin |
KR102564377B1 (ko) * | 2020-02-20 | 2023-08-07 | 쥬빌리바이오텍 주식회사 | 약물 주입을 위한 어플리케이터 및 이에 사용되는 마이크로 니들 패치 |
WO2021167410A1 (ko) * | 2020-02-20 | 2021-08-26 | 쥬빌리바이오텍 주식회사 | 약물 주입을 위한 어플리케이터 및 이에 사용되는 마이크로 니들 패치 |
US11964121B2 (en) | 2021-10-13 | 2024-04-23 | Satio, Inc. | Mono dose dermal patch for pharmaceutical delivery |
US11877848B2 (en) | 2021-11-08 | 2024-01-23 | Satio, Inc. | Dermal patch for collecting a physiological sample |
USD1007676S1 (en) | 2021-11-16 | 2023-12-12 | Regeneron Pharmaceuticals, Inc. | Wearable autoinjector |
US20230181819A1 (en) * | 2021-12-09 | 2023-06-15 | Jubilee Biotech Co., Ltd. | Medication compliance management system |
WO2024000017A1 (en) * | 2022-06-27 | 2024-01-04 | Nutromics Technology Pty Ltd | Apparatus for controlling the introduction of a needle into the skin |
Family Cites Families (577)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US842690A (en) | 1905-12-18 | 1907-01-29 | Eugene B Oswalt | Printing-type. |
US2749797A (en) | 1950-03-21 | 1956-06-12 | Bowser Inc | Sample holder |
US3092465A (en) | 1960-03-25 | 1963-06-04 | Miles Lab | Diagnostic test device for blood sugar |
US3310002A (en) | 1965-10-18 | 1967-03-21 | Robbin Lab Inc | Pipette pump |
DE1598153C3 (de) | 1966-11-22 | 1973-11-22 | Boehringer Mannheim Gmbh, 6800 Mannheim | Diagnostisches Mittel zum Nach weis der Inhaltsstoffe von Korperflus sigkeiten |
CH500707A (fr) | 1968-07-26 | 1970-12-31 | Micromedic Systems Inc | Dispositif pour effectuer une prise de sang percutanée et digitale |
CH522395A (fr) | 1968-07-26 | 1972-05-15 | Micromedic Systems Inc | Eprouvette destinée à la prise de sang percutanée et digitale |
US3620209A (en) | 1970-05-08 | 1971-11-16 | Harvey Kravitz | Device for reducing the pain of injections of medicines and other biologicals |
CH538277A (fr) | 1970-09-04 | 1973-06-30 | Micromedic Systems Inc | Dispositif pour prise de sang percutanée |
US3723064A (en) | 1971-07-26 | 1973-03-27 | L Liotta | Method and device for determining the concentration of a material in a liquid |
US3992158A (en) | 1973-08-16 | 1976-11-16 | Eastman Kodak Company | Integral analytical element |
US3961898A (en) | 1975-01-14 | 1976-06-08 | The United States Of America As Represented By The Secretary Of The Army | Comparator circuit for automatic analysis apparatus |
US4014328A (en) | 1975-06-23 | 1977-03-29 | Cluff Kenneth C | Blood sampling and infusion chamber |
US4042335A (en) | 1975-07-23 | 1977-08-16 | Eastman Kodak Company | Integral element for analysis of liquids |
OA05448A (fr) | 1975-10-16 | 1981-03-31 | Manufrance Manufacture Francai | Dispositif vaccinateur multipénétrant. |
US4057394A (en) | 1976-05-24 | 1977-11-08 | Miles Laboratories, Inc. | Test device and method for determining blood hemoglobin |
JPS5484498A (en) | 1977-12-19 | 1979-07-05 | Hattori Masahiro | Signal for blind person |
US4254083A (en) | 1979-07-23 | 1981-03-03 | Eastman Kodak Company | Structural configuration for transport of a liquid drop through an ingress aperture |
US4258001A (en) | 1978-12-27 | 1981-03-24 | Eastman Kodak Company | Element, structure and method for the analysis or transport of liquids |
US4321397A (en) | 1979-01-31 | 1982-03-23 | Millipore Corporation | 4-Aminoantipyrine dye for the analytic determination of hydrogen peroxide |
US4260257A (en) | 1979-05-29 | 1981-04-07 | Neeley William E | Flow cell |
US4289459A (en) | 1979-08-13 | 1981-09-15 | Neeley William E | Proportioning pump |
IT1130252B (it) | 1980-02-04 | 1986-06-11 | Elvi Spa | Metodo per l'eliminazione dell'interferenza da biliribuna nel dosaggio di perossido di idrigeno mediante una reazione di trinder modificata |
DE3004011A1 (de) | 1980-02-04 | 1981-08-13 | Philips Patentverwaltung Gmbh, 2000 Hamburg | Blutdruck-messvorrichtung |
US4394512A (en) | 1980-02-05 | 1983-07-19 | Boehringer Mannheim Gmbh | 1-(Substituted phenyl) aminoantipyrin compounds |
AU546785B2 (en) * | 1980-07-23 | 1985-09-19 | Commonwealth Of Australia, The | Open-loop controlled infusion of diabetics |
US4422941A (en) | 1980-09-08 | 1983-12-27 | University Of Pittsburgh | Apparatus for liquid-solid column centrifugation chromatography and method |
JPS57174099A (en) | 1981-04-17 | 1982-10-26 | Fuji Photo Film Co Ltd | Color indicator composition for detecting hydrogen peroxide and quantitative analytical film having reagent layer containing the same |
US4414975A (en) | 1981-05-15 | 1983-11-15 | Ryder International Corp. | Blood lancet |
US4416279A (en) | 1981-06-19 | 1983-11-22 | Lindner James A | Capillary blood sampling device |
US4447546A (en) | 1982-08-23 | 1984-05-08 | Myron J. Block | Fluorescent immunoassay employing optical fiber in capillary tube |
US5183741A (en) | 1983-10-13 | 1993-02-02 | Fuji Photo Film Co., Ltd. | Integral multilayer element for glucose analysis |
IT1177513B (it) | 1984-01-27 | 1987-08-26 | Menarini Sas | Reattivo liquido pronto per l'uso per la determinazione del contenuto di glucosio nel sangue |
CA1265963A (en) | 1984-03-02 | 1990-02-20 | George Joseph Duffy | Injection device |
US4661319A (en) | 1984-04-06 | 1987-04-28 | Boehringer Mannheim Diagnostics, Inc. | Blood transfer assembly |
US5141868A (en) | 1984-06-13 | 1992-08-25 | Internationale Octrooi Maatschappij "Octropa" Bv | Device for use in chemical test procedures |
DE3422732A1 (de) | 1984-06-19 | 1985-12-19 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue aminopyrazolinone, ihre herstellung und verwendung |
US4637406A (en) | 1984-08-09 | 1987-01-20 | Hesston Corporation | Chaff and straw spreading attachment for combines |
DE3446637A1 (de) | 1984-12-20 | 1986-07-03 | Boehringer Mannheim Gmbh, 6800 Mannheim | Mittel zur verbesserung des nachweises h(pfeil abwaerts)2(pfeil abwaerts)0(pfeil abwaerts)2(pfeil abwaerts)-liefernder oxidase-reaktionen und seine verwendung |
US4787398A (en) | 1985-04-08 | 1988-11-29 | Garid, Inc. | Glucose medical monitoring system |
US5279294A (en) | 1985-04-08 | 1994-01-18 | Cascade Medical, Inc. | Medical diagnostic system |
US4627445A (en) * | 1985-04-08 | 1986-12-09 | Garid, Inc. | Glucose medical monitoring system |
JPH0627703B2 (ja) * | 1985-05-29 | 1994-04-13 | アーティフィシャル センシング インスツルメンツ エイエスアイ アクチェンゲゼルシャフト | 物質の選択的検出および測定物質内の屈折率変化検知を行なう光学センサ |
US4702261A (en) | 1985-07-03 | 1987-10-27 | Sherwood Medical Company | Biopsy device and method |
US4653513A (en) | 1985-08-09 | 1987-03-31 | Dombrowski Mitchell P | Blood sampler |
US4829470A (en) | 1985-12-12 | 1989-05-09 | International Business Machines Corp. | Text flow around irregular shaped graphic objects |
US5029583A (en) | 1986-07-22 | 1991-07-09 | Personal Diagnostics, Inc. | Optical analyzer |
GB8618578D0 (en) | 1986-07-30 | 1986-09-10 | Turner R C | Lancet device |
US5049487A (en) | 1986-08-13 | 1991-09-17 | Lifescan, Inc. | Automated initiation of timing of reflectance readings |
US4935346A (en) | 1986-08-13 | 1990-06-19 | Lifescan, Inc. | Minimum procedure system for the determination of analytes |
US5059394A (en) | 1986-08-13 | 1991-10-22 | Lifescan, Inc. | Analytical device for the automated determination of analytes in fluids |
US4790979A (en) | 1986-08-29 | 1988-12-13 | Technimed Corporation | Test strip and fixture |
US4711250A (en) | 1986-09-09 | 1987-12-08 | Gilbaugh Jr James H | Hand-held medical syringe actuator device |
US4966646A (en) | 1986-09-24 | 1990-10-30 | Board Of Trustees Of Leland Stanford University | Method of making an integrated, microminiature electric-to-fluidic valve |
US5308767A (en) | 1986-10-31 | 1994-05-03 | Fuji Photo Film Co., Ltd. | Method for control or calibration in a chemical analytical determination |
US4794926A (en) | 1986-11-24 | 1989-01-03 | Invictus, Inc. | Lancet cartridge |
FR2609885B1 (fr) | 1987-01-22 | 1989-04-14 | Cassou Robert | Instrument pour l'insemination artificielle, le transfert d'embryons ou le prelevement de liquides folliculaires chez les mammiferes |
US4774192A (en) | 1987-01-28 | 1988-09-27 | Technimed Corporation | A dry reagent delivery system with membrane having porosity gradient |
US4849340A (en) | 1987-04-03 | 1989-07-18 | Cardiovascular Diagnostics, Inc. | Reaction system element and method for performing prothrombin time assay |
JPS63305841A (ja) | 1987-06-09 | 1988-12-13 | Omron Tateisi Electronics Co | 指用電子血圧計 |
US5218966A (en) | 1987-06-12 | 1993-06-15 | Omron Tateisi Electronics Co. | Electronic blood pressure meter |
NL8702370A (nl) | 1987-10-05 | 1989-05-01 | Groningen Science Park | Werkwijze en stelsel voor glucosebepaling en daarvoor bruikbaar meetcelsamenstel. |
US4929426A (en) | 1987-11-02 | 1990-05-29 | Biologix, Inc. | Portable blood chemistry measuring apparatus |
US4887306A (en) | 1987-11-04 | 1989-12-12 | Advanced Technology Laboratories, Inc. | Adaptive temporal filter for ultrasound imaging system |
DK163194C (da) | 1988-12-22 | 1992-06-22 | Radiometer As | Fremgangsmaade ved fotometrisk in vitro bestemmelse af en blodgasparameter i en blodproeve |
US4844095A (en) * | 1987-12-14 | 1989-07-04 | Medicore, Inc. | Automatic lancet device |
JPH0752170B2 (ja) | 1988-05-27 | 1995-06-05 | ダイキン工業株式会社 | 拡散制限膜保持具収容容器 |
US5302513A (en) | 1988-06-29 | 1994-04-12 | Kyowa Medex Co., Ltd. | Method for determination of components |
FI81120C (fi) | 1988-09-26 | 1990-09-10 | Kone Oy | Foerfarande foer bestaemning av glukos ur biologiska vaetska samt reagensblandning foer tillaempning av foerfarandet. |
US5108889A (en) | 1988-10-12 | 1992-04-28 | Thorne, Smith, Astill Technologies, Inc. | Assay for determining analyte using mercury release followed by detection via interaction with aluminum |
US4920977A (en) | 1988-10-25 | 1990-05-01 | Becton, Dickinson And Company | Blood collection assembly with lancet and microcollection tube |
US4983178A (en) * | 1988-11-14 | 1991-01-08 | Invictus, Inc. | Lancing device |
US5035704A (en) | 1989-03-07 | 1991-07-30 | Lambert Robert D | Blood sampling mechanism |
US5114350A (en) | 1989-03-08 | 1992-05-19 | Cholestech Corporation | Controlled-volume assay apparatus |
US4930525A (en) | 1989-03-28 | 1990-06-05 | Palestrant Aubrey M | Method for performing C.T. guided drainage and biopsy procedures |
US4953552A (en) | 1989-04-21 | 1990-09-04 | Demarzo Arthur P | Blood glucose monitoring system |
US5145565A (en) | 1989-05-01 | 1992-09-08 | Spacelabs, Inc. | Contamination-free method and apparatus for measuring body fluid chemical parameters |
EP0397424A3 (en) | 1989-05-08 | 1991-08-21 | Biotrack, Inc. | Multiple analysis system |
IT1231916B (it) | 1989-05-29 | 1992-01-15 | Ampliscientifica S R L | Pancreas artificiale indossabile |
US4929462A (en) | 1989-06-21 | 1990-05-29 | Kraft General Foods, Inc. | Method and apparatus for continuous contact of supercritical fluid with particulate solids |
US5506200A (en) | 1992-02-06 | 1996-04-09 | Biomagnetic Technologies, Inc. | Compact superconducting magnetometer having no vacuum insulation |
US5306623A (en) | 1989-08-28 | 1994-04-26 | Lifescan, Inc. | Visual blood glucose concentration test strip |
JPH0393189A (ja) | 1989-09-04 | 1991-04-18 | Matsushita Electron Corp | 薄膜el素子の製造方法 |
US5153416A (en) | 1989-09-20 | 1992-10-06 | Neeley William E | Procedure and assembly for drawing blood |
US5166498A (en) | 1989-09-20 | 1992-11-24 | Neeley William E | Procedure and assembly for drawing blood |
US5697901A (en) | 1989-12-14 | 1997-12-16 | Elof Eriksson | Gene delivery by microneedle injection |
US6090790A (en) | 1989-12-14 | 2000-07-18 | Eriksson; Elof | Gene delivery by microneedle injection |
DE3942357A1 (de) | 1989-12-21 | 1991-06-27 | Boehringer Mannheim Gmbh | 3-aminopyrazolo-heterocyclen, deren verwendung zur bestimmung von wasserstoffperoxid, wasserstoffperoxid-bildenden systemen, peroxidase, peroxidatisch wirksamen substanzen oder von elektronenreichen aromatischen verbindungen, entsprechende bestimmungsverfahren und hierfuer geeignete mittel |
JPH0767861A (ja) | 1989-12-27 | 1995-03-14 | 2 モスコフスキ ゴスダルストベンニ メディツィンスキ インスティテュト イメニ エヌ.イー.ピロゴバ | 使い捨て型血液レーザ照射装置 |
US5050617A (en) | 1990-02-20 | 1991-09-24 | Eastman Kodak Company | Removable handle and means for attachment to a syringe or phlebotomy device |
US5115805A (en) | 1990-02-23 | 1992-05-26 | Cygnus Therapeutic Systems | Ultrasound-enhanced delivery of materials into and through the skin |
FR2659759B1 (fr) | 1990-03-14 | 1995-03-17 | Boucheron | Montre a bracelet amovible. |
US5110724A (en) | 1990-04-02 | 1992-05-05 | Cholestech Corporation | Multi-analyte assay device |
US5116759A (en) | 1990-06-27 | 1992-05-26 | Fiberchem Inc. | Reservoir chemical sensors |
US5208163A (en) | 1990-08-06 | 1993-05-04 | Miles Inc. | Self-metering fluid analysis device |
US5196302A (en) | 1990-08-29 | 1993-03-23 | The United States Of America As Represented By The Sectetary Of The Navy | Enzymatic assays using superabsorbent materials |
US5251126A (en) | 1990-10-29 | 1993-10-05 | Miles Inc. | Diabetes data analysis and interpretation method |
US5312456A (en) | 1991-01-31 | 1994-05-17 | Carnegie Mellon University | Micromechanical barb and method for making the same |
US5593852A (en) | 1993-12-02 | 1997-01-14 | Heller; Adam | Subcutaneous glucose electrode |
DE4138702A1 (de) | 1991-03-22 | 1992-09-24 | Madaus Medizin Elektronik | Verfahren und vorrichtung zur diagnose und quantitativen analyse von apnoe und zur gleichzeitigen feststellung anderer erkrankungen |
US5164575A (en) | 1991-04-23 | 1992-11-17 | Neeley William E | Blood sampling procedure and apparatus |
US5167238A (en) | 1991-05-02 | 1992-12-01 | Cobe Laboratories, Inc. | Fluid sampling device |
US5401110A (en) | 1991-07-15 | 1995-03-28 | Neeley; William E. | Custom label printer |
US5131404A (en) | 1991-07-15 | 1992-07-21 | Neeley William E | Capillary tube carrier with putty-filled cap |
US5402798A (en) | 1991-07-18 | 1995-04-04 | Swierczek; Remi | Disposable skin perforator and blood testing device |
JP2601075B2 (ja) | 1991-10-21 | 1997-04-16 | 株式会社日立製作所 | 試験片を用いる分析方法および分析装置 |
USD341848S (en) | 1991-12-09 | 1993-11-30 | Microsoft Corporation | Typeface |
JP2572823Y2 (ja) | 1992-02-13 | 1998-05-25 | 株式会社アドバンス | 簡易採血器 |
US5441513A (en) | 1992-03-12 | 1995-08-15 | United States Surgical Corporation | Retracting tip trocar assembly |
JP3382632B2 (ja) | 1992-03-13 | 2003-03-04 | オリンパス光学工業株式会社 | 生体関連物質の測定方法およびそれに用いる反応容器 |
US5460777A (en) | 1992-03-16 | 1995-10-24 | Fuji Photo Film Co., Ltd. | Analytical element for whole blood analysis |
US5223219A (en) | 1992-04-10 | 1993-06-29 | Biotrack, Inc. | Analytical cartridge and system for detecting analytes in liquid samples |
US5354537A (en) | 1992-04-27 | 1994-10-11 | Akzo N.V. | Piercing and sampling probe |
GR1002549B (el) * | 1992-05-12 | 1997-01-28 | Lifescan Inc. | Λωρις εξετασεως με μεταφορικο μεσο δια μεταφορα ρευστου. |
DE4217733A1 (de) | 1992-05-29 | 1993-12-02 | Boehringer Mannheim Gmbh | Testträger zur Analytbestimmung sowie Verfahren zu dessen Herstellung |
US5217480A (en) | 1992-06-09 | 1993-06-08 | Habley Medical Technology Corporation | Capillary blood drawing device |
US5241969A (en) | 1992-06-10 | 1993-09-07 | Carson Jay W | Controlled and safe fine needle aspiration device |
US5278079A (en) | 1992-09-02 | 1994-01-11 | Enzymatics, Inc. | Sealing device and method for inhibition of flow in capillary measuring devices |
US6172743B1 (en) | 1992-10-07 | 2001-01-09 | Chemtrix, Inc. | Technique for measuring a blood analyte by non-invasive spectrometry in living tissue |
US5314441A (en) * | 1992-10-16 | 1994-05-24 | International Technidyne Corporation | Disposable slicing lancet assembly |
US5508200A (en) | 1992-10-19 | 1996-04-16 | Tiffany; Thomas | Method and apparatus for conducting multiple chemical assays |
US5269800A (en) * | 1992-12-10 | 1993-12-14 | Davis Manufacturing Systems Inc. | Blood lancing device |
DK148592D0 (da) | 1992-12-10 | 1992-12-10 | Novo Nordisk As | Apparat |
US5299571A (en) | 1993-01-22 | 1994-04-05 | Eli Lilly And Company | Apparatus and method for implantation of sensors |
US5383512A (en) | 1993-01-27 | 1995-01-24 | Midwest Research Institute | Method for fabricating a substrate having spaced apart microcapillaries thereon |
IT1272109B (it) | 1993-03-19 | 1997-06-11 | Eniricerche Spa | Processo per la preparazione di apg |
DE4313253A1 (de) | 1993-04-23 | 1994-10-27 | Boehringer Mannheim Gmbh | System zur Analyse von Inhaltsstoffen flüssiger Proben |
JP2630197B2 (ja) | 1993-04-28 | 1997-07-16 | 株式会社ニッショー | 血液吸出器具 |
DE4318519C2 (de) | 1993-06-03 | 1996-11-28 | Fraunhofer Ges Forschung | Elektrochemischer Sensor |
US5360595A (en) | 1993-08-19 | 1994-11-01 | Miles Inc. | Preparation of diagnostic test strips containing tetrazolium salt indicators |
US5582184A (en) | 1993-10-13 | 1996-12-10 | Integ Incorporated | Interstitial fluid collection and constituent measurement |
HU219921B (hu) | 1993-10-20 | 2001-09-28 | Ervin Lipscher | Vérvételi eszköz, különösen ujjbegyből történő vérvételre |
WO1995011621A1 (en) | 1993-10-28 | 1995-05-04 | I-Stat Corporation | Fluid sample collection and introduction device |
US5885211A (en) | 1993-11-15 | 1999-03-23 | Spectrix, Inc. | Microporation of human skin for monitoring the concentration of an analyte |
US5458140A (en) | 1993-11-15 | 1995-10-17 | Non-Invasive Monitoring Company (Nimco) | Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers |
US20020169394A1 (en) * | 1993-11-15 | 2002-11-14 | Eppstein Jonathan A. | Integrated tissue poration, fluid harvesting and analysis device, and method therefor |
US5395388A (en) * | 1993-11-15 | 1995-03-07 | Schraga; Steven | Single unit lancet device |
JP3393920B2 (ja) | 1993-12-09 | 2003-04-07 | 富士写真フイルム株式会社 | 微量定容採血点着用具 |
US5841126A (en) | 1994-01-28 | 1998-11-24 | California Institute Of Technology | CMOS active pixel sensor type imaging system on a chip |
US5536249A (en) | 1994-03-09 | 1996-07-16 | Visionary Medical Products, Inc. | Pen-type injector with a microprocessor and blood characteristic monitor |
US5390671A (en) | 1994-03-15 | 1995-02-21 | Minimed Inc. | Transcutaneous sensor insertion set |
DE4415896A1 (de) | 1994-05-05 | 1995-11-09 | Boehringer Mannheim Gmbh | Analysesystem zur Überwachung der Konzentration eines Analyten im Blut eines Patienten |
US5482473A (en) | 1994-05-09 | 1996-01-09 | Minimed Inc. | Flex circuit connector |
US5591139A (en) | 1994-06-06 | 1997-01-07 | The Regents Of The University Of California | IC-processed microneedles |
US5771890A (en) | 1994-06-24 | 1998-06-30 | Cygnus, Inc. | Device and method for sampling of substances using alternating polarity |
US5700695A (en) * | 1994-06-30 | 1997-12-23 | Zia Yassinzadeh | Sample collection and manipulation method |
US5514152A (en) | 1994-08-16 | 1996-05-07 | Specialized Health Products, Inc. | Multiple segment encapsulated medical lancing device |
US6335203B1 (en) | 1994-09-08 | 2002-01-01 | Lifescan, Inc. | Optically readable strip for analyte detection having on-strip orientation index |
WO1996008758A2 (en) | 1994-09-12 | 1996-03-21 | Philips Electronics N.V. | Method of enabling a user to select a service, system for carrying out the method, server for use in the system, and apparatus for use in the system |
US5577499A (en) | 1994-10-03 | 1996-11-26 | Teves; Leonides Y. | Blood analyzer |
GB9422260D0 (en) | 1994-11-04 | 1994-12-21 | Owen Mumford Ltd | Improvements relating to skin prickers |
IE72524B1 (en) * | 1994-11-04 | 1997-04-23 | Elan Med Tech | Analyte-controlled liquid delivery device and analyte monitor |
US5585069A (en) | 1994-11-10 | 1996-12-17 | David Sarnoff Research Center, Inc. | Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis |
US5630986A (en) | 1995-01-13 | 1997-05-20 | Bayer Corporation | Dispensing instrument for fluid monitoring sensors |
US5575403A (en) | 1995-01-13 | 1996-11-19 | Bayer Corporation | Dispensing instrument for fluid monitoring sensors |
EP0989515A3 (en) | 1995-01-17 | 2001-01-17 | Sega Enterprises, Ltd. | Image processing method and electronic device |
US5568806A (en) | 1995-02-16 | 1996-10-29 | Minimed Inc. | Transcutaneous sensor insertion set |
US5586553A (en) | 1995-02-16 | 1996-12-24 | Minimed Inc. | Transcutaneous sensor insertion set |
CA2218075A1 (en) | 1995-04-13 | 1996-10-17 | Mir A. Imran | Aspiration needle apparatus incorporating its own vacuum and method and adapter for use therewith |
CA2170560C (en) | 1995-04-17 | 2005-10-25 | Joseph L. Moulton | Means of handling multiple sensors in a glucose monitoring instrument system |
FR2733745B1 (fr) | 1995-05-02 | 1997-07-04 | Asulab Sa | Appareil perfectionne destine a la ditribution de zones successives d'une bande consommable |
US5510266A (en) | 1995-05-05 | 1996-04-23 | Bayer Corporation | Method and apparatus of handling multiple sensors in a glucose monitoring instrument system |
US5701181A (en) * | 1995-05-12 | 1997-12-23 | Bayer Corporation | Fiber optic diffuse light reflectance sensor utilized in the detection of occult blood |
WO1996037155A1 (en) | 1995-05-22 | 1996-11-28 | Silicon Microdevices, Inc. | Micromechanical device and method for enhancing delivery of compounds through the skin |
JPH08317918A (ja) | 1995-05-25 | 1996-12-03 | Advance Co Ltd | 採血装置 |
US5708787A (en) | 1995-05-29 | 1998-01-13 | Matsushita Electric Industrial | Menu display device |
US5647851A (en) | 1995-06-12 | 1997-07-15 | Pokras; Norman M. | Method and apparatus for vibrating an injection device |
US6041253A (en) | 1995-12-18 | 2000-03-21 | Massachusetts Institute Of Technology | Effect of electric field and ultrasound for transdermal drug delivery |
US5730753A (en) | 1995-07-28 | 1998-03-24 | Apls Co., Ltd. | Assembly for adjusting pricking depth of lancet |
US6058321A (en) | 1995-09-07 | 2000-05-02 | Swayze; Claude R. | Instrument for continuously monitoring fetal heart rate and intermittently monitoring fetal blood pH and method of use |
WO1997010745A1 (en) | 1995-09-08 | 1997-03-27 | Integ, Inc. | Body fluid sampler |
US5879367A (en) | 1995-09-08 | 1999-03-09 | Integ, Inc. | Enhanced interstitial fluid collection |
US5682233A (en) | 1995-09-08 | 1997-10-28 | Integ, Inc. | Interstitial fluid sampler |
US5989409A (en) | 1995-09-11 | 1999-11-23 | Cygnus, Inc. | Method for glucose sensing |
US5735273A (en) | 1995-09-12 | 1998-04-07 | Cygnus, Inc. | Chemical signal-impermeable mask |
US5658515A (en) | 1995-09-25 | 1997-08-19 | Lee; Abraham P. | Polymer micromold and fabrication process |
JPH09168530A (ja) * | 1995-10-17 | 1997-06-30 | Dainippon Printing Co Ltd | 体液採取器具及びそれを用いた体液分析装置 |
US5746720A (en) | 1995-10-18 | 1998-05-05 | Stouder, Jr.; Albert E. | Method and apparatus for insertion of a cannula and trocar |
US5741211A (en) | 1995-10-26 | 1998-04-21 | Medtronic, Inc. | System and method for continuous monitoring of diabetes-related blood constituents |
US5705018A (en) | 1995-12-13 | 1998-01-06 | Hartley; Frank T. | Micromachined peristaltic pump |
DE69634265T2 (de) | 1995-12-19 | 2006-04-27 | Abbott Laboratories, Abbott Park | Vorrichtung zum detektieren eines analyten und zur verabreichung einer therapeutischen substanz |
JP3316820B2 (ja) | 1995-12-28 | 2002-08-19 | シィグナス インコーポレィティド | 被験者の生理的分析物の継続モニタリング装置及び方法 |
FI118509B (fi) | 1996-02-12 | 2007-12-14 | Nokia Oyj | Menetelmä ja laitteisto potilaan veren glukoosipitoisuuden ennustamiseksi |
US5989917A (en) | 1996-02-13 | 1999-11-23 | Selfcare, Inc. | Glucose monitor and test strip containers for use in same |
US5708247A (en) | 1996-02-14 | 1998-01-13 | Selfcare, Inc. | Disposable glucose test strips, and methods and compositions for making same |
US6241862B1 (en) | 1996-02-14 | 2001-06-05 | Inverness Medical Technology, Inc. | Disposable test strips with integrated reagent/blood separation layer |
US5801057A (en) | 1996-03-22 | 1998-09-01 | Smart; Wilson H. | Microsampling device and method of construction |
EP0798004A1 (de) | 1996-03-29 | 1997-10-01 | Wagner, Wolfgang, Dr.med. | Einrichtung und einrichtungsbezogenes Verfahren für die Stoffwechselkontrolle bei einem Lebewesen |
DE19705091A1 (de) | 1996-03-29 | 1999-02-11 | Wolfgang Dr Med Wagner | Einrichtungsbezogenes Verfahren und Punktionseinrichtung für die Blutgewinnung aus der Haut eines Lebewesens und angeschlossene Stoffwechselmessung |
JP3605225B2 (ja) | 1996-04-01 | 2004-12-22 | 大日本印刷株式会社 | 体液分析装置 |
DE69700499T2 (de) | 1996-04-03 | 2000-03-23 | Perkin Elmer Corp | Vorrichtung und verfahren zum nachweis mehrerer analyten |
IL120587A (en) | 1996-04-04 | 2000-10-31 | Lifescan Inc | Reagent test strip for determination of blood glucose |
US5962215A (en) | 1996-04-05 | 1999-10-05 | Mercury Diagnostics, Inc. | Methods for testing the concentration of an analyte in a body fluid |
US5989845A (en) | 1996-04-05 | 1999-11-23 | Mercury Diagnostics, Inc. | Diagnostic compositions and devices utilizing same |
CA2250400A1 (en) | 1996-04-30 | 1997-11-06 | Metrika, Inc. | Method and device for measuring reflected optical radiation |
JP3604804B2 (ja) * | 1996-05-07 | 2004-12-22 | 大日本印刷株式会社 | 体液分析装置 |
US20020010406A1 (en) | 1996-05-17 | 2002-01-24 | Douglas Joel S. | Methods and apparatus for expressing body fluid from an incision |
EP1862116A3 (en) | 1996-05-17 | 2009-02-25 | Roche Diagnostics Operations, Inc. | Disposable element for use in a body fluid sampling device |
US5951492A (en) | 1996-05-17 | 1999-09-14 | Mercury Diagnostics, Inc. | Methods and apparatus for sampling and analyzing body fluid |
EP0955914B1 (en) | 1996-05-17 | 2010-02-24 | Roche Diagnostics Operations, Inc. | Apparatus for sampling body fluid from an incision |
US5951493A (en) | 1997-05-16 | 1999-09-14 | Mercury Diagnostics, Inc. | Methods and apparatus for expressing body fluid from an incision |
EP1579814A3 (en) | 1996-05-17 | 2006-06-14 | Roche Diagnostics Operations, Inc. | Methods and apparatus for sampling and analyzing body fluid |
EP0904022B1 (en) | 1996-05-17 | 2007-04-04 | Roche Diagnostics Operations, Inc. | Apparatus for sampling body fluid |
US7666150B2 (en) | 1996-05-17 | 2010-02-23 | Roche Diagnostics Operations, Inc. | Blood and interstitial fluid sampling device |
US6332871B1 (en) | 1996-05-17 | 2001-12-25 | Amira Medical | Blood and interstitial fluid sampling device |
US5879311A (en) | 1996-05-17 | 1999-03-09 | Mercury Diagnostics, Inc. | Body fluid sampling device and methods of use |
US5945678A (en) | 1996-05-21 | 1999-08-31 | Hamamatsu Photonics K.K. | Ionizing analysis apparatus |
US5954685A (en) | 1996-05-24 | 1999-09-21 | Cygnus, Inc. | Electrochemical sensor with dual purpose electrode |
JP3604808B2 (ja) | 1996-05-28 | 2004-12-22 | 大日本印刷株式会社 | 体液分析装置 |
US5766066A (en) | 1996-06-05 | 1998-06-16 | Ranniger; Richard L. | Skinning machine |
US5660791A (en) | 1996-06-06 | 1997-08-26 | Bayer Corporation | Fluid testing sensor for use in dispensing instrument |
ES2195151T3 (es) | 1996-06-18 | 2003-12-01 | Alza Corp | Dispositivo de mejora de aporte o de muestreo de agentes transdermicos. |
US5797898A (en) | 1996-07-02 | 1998-08-25 | Massachusetts Institute Of Technology | Microchip drug delivery devices |
CA2259437C (en) | 1996-07-03 | 2006-12-05 | Altea Technologies, Inc. | Multiple mechanical microporation of skin or mucosa |
JP3604819B2 (ja) | 1996-07-11 | 2004-12-22 | 大日本印刷株式会社 | 体液分析装置 |
AT404513B (de) | 1996-07-12 | 1998-12-28 | Avl Verbrennungskraft Messtech | Verfahren und messanordnung zur optischen bestimmung der totalen hämoglobinkonzentration |
US5858194A (en) | 1996-07-18 | 1999-01-12 | Beckman Instruments, Inc. | Capillary, interface and holder |
DE19629657A1 (de) | 1996-07-23 | 1998-01-29 | Boehringer Mannheim Gmbh | Volumenunabhängiger diagnostischer Testträger und Verfahren zur Bestimmung von Analyt mit dessen Hilfe |
JPH1033196A (ja) | 1996-07-23 | 1998-02-10 | Unitika Ltd | 試験片 |
US5736103A (en) | 1996-08-09 | 1998-04-07 | Lifescan, Inc. | Remote-dosing analyte concentration meter |
US5851215A (en) * | 1996-09-24 | 1998-12-22 | International Technidyne Corporation | Low cost disposable lancet |
US5772677A (en) | 1996-09-24 | 1998-06-30 | International Technidyne Corporation | Incision device capable of automatic assembly and a method of assembly |
US6146361A (en) | 1996-09-26 | 2000-11-14 | Becton Dickinson And Company | Medication delivery pen having a 31 gauge needle |
IT240946Y1 (it) | 1996-10-11 | 2001-04-20 | Lascor Spa | Sistema di aggancio di un bracciale a casse di orologi |
WO1998019159A1 (en) | 1996-10-30 | 1998-05-07 | Mercury Diagnostics, Inc. | Synchronized analyte testing system |
US5856195A (en) | 1996-10-30 | 1999-01-05 | Bayer Corporation | Method and apparatus for calibrating a sensor element |
DE19781288B4 (de) | 1996-11-08 | 2005-09-29 | Amira Medical, Scotts Valley | Opake Reaktionsmatrix zur Analyse von Vollblut |
USD389761S (en) | 1996-11-12 | 1998-01-27 | Chromatography Research Supplies, Inc. | Cartridge cap |
DE19648844C1 (de) | 1996-11-26 | 1997-09-18 | Jenoptik Jena Gmbh | Einrichtung und Verfahren zur Abformung mikrosystemtechnischer Strukturen |
US5866281A (en) | 1996-11-27 | 1999-02-02 | Wisconsin Alumni Research Foundation | Alignment method for multi-level deep x-ray lithography utilizing alignment holes and posts |
US6027459A (en) | 1996-12-06 | 2000-02-22 | Abbott Laboratories | Method and apparatus for obtaining blood for diagnostic tests |
US6063039A (en) | 1996-12-06 | 2000-05-16 | Abbott Laboratories | Method and apparatus for obtaining blood for diagnostic tests |
DE19652784A1 (de) | 1996-12-19 | 1998-06-25 | Dade Behring Marburg Gmbh | Vorrichtung (Küvette) zur Aufnahme und Speicherung von Flüssigkeiten und zur Durchführung optischer Messungen |
ES2124186B1 (es) | 1997-01-20 | 1999-08-01 | Carpe Diem Salud S L | Apartado y sistema de control telematico de parametros fisiologicos de pacientes. |
JP3394262B2 (ja) | 1997-02-06 | 2003-04-07 | セラセンス、インク. | 小体積インビトロ被検体センサー |
US6056734A (en) | 1997-02-07 | 2000-05-02 | Sarcos Lc | Method for automatic dosing of drugs |
US5911737A (en) | 1997-02-28 | 1999-06-15 | The Regents Of The University Of California | Microfabricated therapeutic actuators |
US6001067A (en) | 1997-03-04 | 1999-12-14 | Shults; Mark C. | Device and method for determining analyte levels |
US6014135A (en) | 1997-04-04 | 2000-01-11 | Netscape Communications Corp. | Collaboration centric document processing environment using an information centric visual user interface and information presentation method |
US5885839A (en) | 1997-04-15 | 1999-03-23 | Lxn Corporation | Methods of determining initiation and variable end points for measuring a chemical reaction |
US5759364A (en) | 1997-05-02 | 1998-06-02 | Bayer Corporation | Electrochemical biosensor |
IL132688A (en) | 1997-05-05 | 2005-08-31 | Chemometec As | Method and system for determination of particles in a liquid sample |
US6391645B1 (en) | 1997-05-12 | 2002-05-21 | Bayer Corporation | Method and apparatus for correcting ambient temperature effect in biosensors |
USD403975S (en) | 1997-06-17 | 1999-01-12 | Mercury Diagnostics, Inc. | Test strip device |
US5948695A (en) | 1997-06-17 | 1999-09-07 | Mercury Diagnostics, Inc. | Device for determination of an analyte in a body fluid |
US5928207A (en) | 1997-06-30 | 1999-07-27 | The Regents Of The University Of California | Microneedle with isotropically etched tip, and method of fabricating such a device |
US5893870A (en) | 1997-07-21 | 1999-04-13 | Actilife L.L.C. | Device and method for restricting venous flow for improved blood sampling |
US6066243A (en) * | 1997-07-22 | 2000-05-23 | Diametrics Medical, Inc. | Portable immediate response medical analyzer having multiple testing modules |
US6045753A (en) | 1997-07-29 | 2000-04-04 | Sarnoff Corporation | Deposited reagents for chemical processes |
JPH1156822A (ja) | 1997-08-19 | 1999-03-02 | Omron Corp | 血糖測定装置 |
US6061128A (en) | 1997-09-04 | 2000-05-09 | Avocet Medical, Inc. | Verification device for optical clinical assay systems |
US6001239A (en) * | 1998-09-30 | 1999-12-14 | Mercury Diagnostics, Inc. | Membrane based electrochemical test device and related methods |
DE69803310T2 (de) * | 1997-09-30 | 2002-08-14 | Amira Medical Scotts Valley | Analytisches gerät mit kapillarreagenzträger |
US6097831A (en) | 1997-10-14 | 2000-08-01 | Chiron Corporation | Non-contract method for assay reagent volume dispense verification |
US5938679A (en) | 1997-10-14 | 1999-08-17 | Hewlett-Packard Company | Apparatus and method for minimally invasive blood sampling |
JP2001522047A (ja) | 1997-10-31 | 2001-11-13 | サーノフ コーポレイション | 蛍光を増強する方法 |
JPH11146325A (ja) | 1997-11-10 | 1999-05-28 | Hitachi Ltd | 映像検索方法および装置並びに映像情報作成方法およびその処理プログラムを格納した記憶媒体 |
US6706000B2 (en) | 1997-11-21 | 2004-03-16 | Amira Medical | Methods and apparatus for expressing body fluid from an incision |
US5871494A (en) | 1997-12-04 | 1999-02-16 | Hewlett-Packard Company | Reproducible lancing for sampling blood |
US5971941A (en) | 1997-12-04 | 1999-10-26 | Hewlett-Packard Company | Integrated system and method for sampling blood and analysis |
US6036924A (en) | 1997-12-04 | 2000-03-14 | Hewlett-Packard Company | Cassette of lancet cartridges for sampling blood |
US6071294A (en) * | 1997-12-04 | 2000-06-06 | Agilent Technologies, Inc. | Lancet cartridge for sampling blood |
US6579690B1 (en) | 1997-12-05 | 2003-06-17 | Therasense, Inc. | Blood analyte monitoring through subcutaneous measurement |
US5986754A (en) | 1997-12-08 | 1999-11-16 | Lifescan, Inc. | Medical diagnostic apparatus using a Fresnel reflector |
US6322808B1 (en) | 1997-12-11 | 2001-11-27 | Alza Corporation | Device for enhancing transdermal agent flux |
US6083196A (en) | 1997-12-11 | 2000-07-04 | Alza Corporation | Device for enhancing transdermal agent flux |
DE69806963T2 (de) | 1997-12-11 | 2002-11-21 | Alza Corp | Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses |
WO1999032883A2 (en) | 1997-12-19 | 1999-07-01 | Amira Medical | Embossed test strip system |
US7407811B2 (en) | 1997-12-22 | 2008-08-05 | Roche Diagnostics Operations, Inc. | System and method for analyte measurement using AC excitation |
US6030827A (en) | 1998-01-23 | 2000-02-29 | I-Stat Corporation | Microfabricated aperture-based sensor |
US6394952B1 (en) | 1998-02-03 | 2002-05-28 | Adeza Biomedical Corporation | Point of care diagnostic systems |
US6103033A (en) | 1998-03-04 | 2000-08-15 | Therasense, Inc. | Process for producing an electrochemical biosensor |
AU2898699A (en) | 1998-03-06 | 1999-09-20 | Altea Technologies, Inc. | Photothermal structure for biomedical applications, and method therefor |
JP3109470B2 (ja) * | 1998-03-11 | 2000-11-13 | 日本電気株式会社 | 角質層穿刺針及び角質層穿刺部材 |
US6106751A (en) | 1998-03-18 | 2000-08-22 | The Regents Of The University Of California | Method for fabricating needles via conformal deposition in two-piece molds |
AU6309799A (en) | 1998-03-19 | 2001-02-13 | Sims Portex, Inc. | Anticoagulant internally coated needle |
US6139562A (en) | 1998-03-30 | 2000-10-31 | Agilent Technologies, Inc. | Apparatus and method for incising |
JPH11281779A (ja) | 1998-03-30 | 1999-10-15 | Kdk Corp | データ測定器 |
US6391005B1 (en) | 1998-03-30 | 2002-05-21 | Agilent Technologies, Inc. | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
US6091975A (en) | 1998-04-01 | 2000-07-18 | Alza Corporation | Minimally invasive detecting device |
US6175752B1 (en) | 1998-04-30 | 2001-01-16 | Therasense, Inc. | Analyte monitoring device and methods of use |
US6123798A (en) | 1998-05-06 | 2000-09-26 | Caliper Technologies Corp. | Methods of fabricating polymeric structures incorporating microscale fluidic elements |
EP1077634B1 (en) | 1998-05-13 | 2003-07-30 | Cygnus, Inc. | Monitoring of physiological analytes |
DE69910007T2 (de) * | 1998-05-13 | 2004-04-22 | Cygnus, Inc., Redwood City | Vorrichtung zum vorhersagen von physiologischen messwerten |
CA2329411C (en) * | 1998-05-13 | 2004-01-27 | Cygnus, Inc. | Collection assemblies for transdermal sampling system |
JP2002516723A (ja) | 1998-06-04 | 2002-06-11 | エラン コーポレーシヨン ピーエルシー | ガス駆動の薬投与装置 |
US6312888B1 (en) | 1998-06-10 | 2001-11-06 | Abbott Laboratories | Diagnostic assay for a sample of biological fluid |
US6503231B1 (en) * | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
EP1086214B1 (en) * | 1998-06-10 | 2009-11-25 | Georgia Tech Research Corporation | Microneedle devices and methods of their manufacture |
US6077660A (en) | 1998-06-10 | 2000-06-20 | Abbott Laboratories | Diagnostic assay requiring a small sample of biological fluid |
US5911711A (en) | 1998-06-29 | 1999-06-15 | Becton, Dickinson And Company | Lubricant system for hypodermic needles and method for its application |
ES2185374T3 (es) | 1998-07-07 | 2003-04-16 | Lightouch Medical Inc | Procedimiento de modulacion tisular para el analisis espectroscopico cuantitativo in vivo, no invasor de tejidos. |
US6493069B1 (en) | 1998-07-24 | 2002-12-10 | Terumo Kabushiki Kaisha | Method and instrument for measuring blood sugar level |
USD411621S (en) | 1998-07-27 | 1999-06-29 | Boehringer Mannheim Gmbh | Blood glucose meter |
US6100107A (en) | 1998-08-06 | 2000-08-08 | Industrial Technology Research Institute | Microchannel-element assembly and preparation method thereof |
GB9817662D0 (en) * | 1998-08-13 | 1998-10-07 | Crocker Peter J | Substance delivery |
US6558320B1 (en) | 2000-01-20 | 2003-05-06 | Medtronic Minimed, Inc. | Handheld personal data assistant (PDA) with a medical device and method of using the same |
JP3170485B2 (ja) * | 1998-08-24 | 2001-05-28 | 株式会社 秀逸開発 | 携帯用自動注射器及び注射針ユニット |
US6251260B1 (en) | 1998-08-24 | 2001-06-26 | Therasense, Inc. | Potentiometric sensors for analytic determination |
JP2002524120A (ja) * | 1998-09-04 | 2002-08-06 | パウダージェクト リサーチ リミテッド | 粒子送達法を使用するモニタリング方法 |
WO2000014535A1 (en) | 1998-09-09 | 2000-03-16 | Amira Medical | Interstitial fluid methods and devices for determination of an analyte in the body |
EP1113832A4 (en) * | 1998-09-18 | 2002-04-17 | Univ Utah Res Found | MICRO-MACHINED NEEDLES ON A SURFACE |
US6254586B1 (en) * | 1998-09-25 | 2001-07-03 | Minimed Inc. | Method and kit for supplying a fluid to a subcutaneous placement site |
US5951521A (en) | 1998-09-25 | 1999-09-14 | Minimed Inc. | Subcutaneous implantable sensor set having the capability to remove deliver fluids to an insertion site |
DE19844500A1 (de) | 1998-09-29 | 2000-03-30 | Roche Diagnostics Gmbh | Verfahren zur photometrischen Auswertung von Testelementen |
CA2653180C (en) | 1998-09-30 | 2013-11-19 | Medtronic Minimed, Inc. | Communication station and software for interfacing with an infusion pump, analyte monitor, analyte meter, or the like |
US6338790B1 (en) * | 1998-10-08 | 2002-01-15 | Therasense, Inc. | Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator |
US6591125B1 (en) * | 2000-06-27 | 2003-07-08 | Therasense, Inc. | Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator |
JP2000116629A (ja) | 1998-10-15 | 2000-04-25 | Kdk Corp | 装着体 |
JP3633317B2 (ja) | 1998-10-22 | 2005-03-30 | ニプロ株式会社 | 穿刺針を備えた血液検査具 |
JP3093189B2 (ja) | 1998-12-01 | 2000-10-03 | 大阪シーリング印刷株式会社 | ラベル貼付装置およびラベル貼付方法 |
US6312812B1 (en) | 1998-12-01 | 2001-11-06 | Ppg Industries Ohio, Inc. | Coated metal substrates and methods for preparing and inhibiting corrosion of the same |
USD417504S (en) | 1998-12-04 | 1999-12-07 | Lifescan, Inc. | Blood glucose meter |
JP2000175699A (ja) * | 1998-12-15 | 2000-06-27 | Fuji Photo Film Co Ltd | 一体型多層化学分析要素および測定方法 |
US6388750B1 (en) | 1998-12-17 | 2002-05-14 | Beckman Coulter, Inc. | Device and method for preliminary testing a neat serum sample in a primary collection tube |
JP3659832B2 (ja) * | 1999-03-10 | 2005-06-15 | テルモ株式会社 | 体液成分測定装置 |
CN1191786C (zh) | 1999-01-04 | 2005-03-09 | 泰尔茂株式会社 | 具有穿刺部件和体液采集检测装置的组件 |
US6360888B1 (en) | 1999-02-25 | 2002-03-26 | Minimed Inc. | Glucose sensor package system |
US6660018B2 (en) | 1999-03-08 | 2003-12-09 | Agilent Technologies, Inc. | Multiple lancet device |
US6132449A (en) | 1999-03-08 | 2000-10-17 | Agilent Technologies, Inc. | Extraction and transportation of blood for analysis |
US6368563B1 (en) | 1999-03-12 | 2002-04-09 | Integ, Inc. | Collection well for body fluid tester |
US6203051B1 (en) * | 1999-03-23 | 2001-03-20 | Jeffrey P. Sabol | Safety rotatable snowboard boot binding |
US6086544A (en) | 1999-03-31 | 2000-07-11 | Ethicon Endo-Surgery, Inc. | Control apparatus for an automated surgical biopsy device |
US6231531B1 (en) | 1999-04-09 | 2001-05-15 | Agilent Technologies, Inc. | Apparatus and method for minimizing pain perception |
US6192891B1 (en) | 1999-04-26 | 2001-02-27 | Becton Dickinson And Company | Integrated system including medication delivery pen, blood monitoring device, and lancer |
US6748275B2 (en) | 1999-05-05 | 2004-06-08 | Respironics, Inc. | Vestibular stimulation system and method |
DE19922413A1 (de) | 1999-05-14 | 2000-11-23 | Volkswagen Ag | Armbanduhr |
EP1187653B1 (en) * | 1999-06-04 | 2010-03-31 | Georgia Tech Research Corporation | Devices for enhanced microneedle penetration of biological barriers |
US6256533B1 (en) * | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
US6312612B1 (en) | 1999-06-09 | 2001-11-06 | The Procter & Gamble Company | Apparatus and method for manufacturing an intracutaneous microneedle array |
US6152942A (en) | 1999-06-14 | 2000-11-28 | Bayer Corporation | Vacuum assisted lancing device |
US6193873B1 (en) * | 1999-06-15 | 2001-02-27 | Lifescan, Inc. | Sample detection to initiate timing of an electrochemical assay |
AU5490600A (en) | 1999-06-18 | 2001-01-09 | Spectrx, Inc. | System and method for monitoring glucose to assist in weight management and fitness training |
US6319209B1 (en) | 1999-08-23 | 2001-11-20 | European Institute Of Science | Disposable test vial with sample delivery device for dispensing sample into a reagent |
AU6931500A (en) | 1999-08-27 | 2001-03-26 | M-Biotech, Inc. | Glucose biosensor |
US6251083B1 (en) * | 1999-09-07 | 2001-06-26 | Amira Medical | Interstitial fluid methods and devices for determination of an analyte in the body |
US6331266B1 (en) | 1999-09-29 | 2001-12-18 | Becton Dickinson And Company | Process of making a molded device |
US8465468B1 (en) * | 2000-06-29 | 2013-06-18 | Becton, Dickinson And Company | Intradermal delivery of substances |
US6228100B1 (en) * | 1999-10-25 | 2001-05-08 | Steven Schraga | Multi-use lancet device |
JP4184572B2 (ja) * | 2000-04-27 | 2008-11-19 | 松下電器産業株式会社 | バイオセンサ |
EP1152239A4 (en) | 1999-11-15 | 2009-05-27 | Panasonic Corp | BIODETECTOR, METHOD FOR FORMING THIN FILM ELECTRODE AND METHOD AND APPARATUS FOR QUANTITATIVE DETERMINATION |
JP2001159618A (ja) * | 1999-12-03 | 2001-06-12 | Matsushita Electric Ind Co Ltd | バイオセンサ |
CN1217623C (zh) | 1999-12-13 | 2005-09-07 | 爱科来株式会社 | 带采血针的体液测定装置及用于该装置的采血针支架 |
US7156809B2 (en) | 1999-12-17 | 2007-01-02 | Q-Tec Systems Llc | Method and apparatus for health and disease management combining patient data monitoring with wireless internet connectivity |
AU2736501A (en) | 1999-12-30 | 2001-07-16 | Redeon, Inc. | Stacked microneedle systems |
JP4144019B2 (ja) | 2000-01-07 | 2008-09-03 | ニプロ株式会社 | 穿刺針 |
US6571128B2 (en) * | 2000-01-21 | 2003-05-27 | Medtronic Minimed, Inc. | Microprocessor controlled ambulatory medical apparatus with hand held communication device |
DE10003093C2 (de) | 2000-01-25 | 2002-05-16 | Goltz Volker Freiherr Von | Vorrichtung zur Untersuchung von Eigenschaften der globalen Hämostasefunktion in Vollblut oder plättchenreichem Plasma |
US6706159B2 (en) * | 2000-03-02 | 2004-03-16 | Diabetes Diagnostics | Combined lancet and electrochemical analyte-testing apparatus |
US6375627B1 (en) | 2000-03-02 | 2002-04-23 | Agilent Technologies, Inc. | Physiological fluid extraction with rapid analysis |
US6379969B1 (en) | 2000-03-02 | 2002-04-30 | Agilent Technologies, Inc. | Optical sensor for sensing multiple analytes |
US6620112B2 (en) * | 2000-03-24 | 2003-09-16 | Novo Nordisk A/S | Disposable lancet combined with a reagent carrying strip and a system for extracting and analyzing blood in the body utilizing such a disposable lancet |
US6612111B1 (en) | 2000-03-27 | 2003-09-02 | Lifescan, Inc. | Method and device for sampling and analyzing interstitial fluid and whole blood samples |
US6402704B1 (en) * | 2000-04-18 | 2002-06-11 | Sonexxus Incorporated | Prothrombin test apparatus for home use |
DE10020352A1 (de) | 2000-04-26 | 2001-10-31 | Simons Hans Juergen | Implantierbares Blutzuckermessgerät |
US6659982B2 (en) * | 2000-05-08 | 2003-12-09 | Sterling Medivations, Inc. | Micro infusion drug delivery device |
JP2001330581A (ja) * | 2000-05-19 | 2001-11-30 | Matsushita Electric Ind Co Ltd | 基質濃度定量法 |
DE10026172A1 (de) | 2000-05-26 | 2001-11-29 | Roche Diagnostics Gmbh | System zur Entnahme von Körperflüssigkeit |
US6506168B1 (en) | 2000-05-26 | 2003-01-14 | Abbott Laboratories | Apparatus and method for obtaining blood for diagnostic tests |
DE10026170A1 (de) | 2000-05-26 | 2001-12-06 | Roche Diagnostics Gmbh | System zur Entnahme von Körperflüssigkeit |
US7641856B2 (en) | 2004-05-14 | 2010-01-05 | Honeywell International Inc. | Portable sample analyzer with removable cartridge |
KR20030045678A (ko) | 2000-06-09 | 2003-06-11 | 다이어베티스 다이어그노스틱스, 인크. | 란셋절개 장치용 캡 |
US6409679B2 (en) | 2000-06-13 | 2002-06-25 | Pacific Paragon Investment Fund Ltd. | Apparatus and method for collecting bodily fluid |
US6428664B1 (en) | 2000-06-19 | 2002-08-06 | Roche Diagnostics Corporation | Biosensor |
US6540675B2 (en) | 2000-06-27 | 2003-04-01 | Rosedale Medical, Inc. | Analyte monitor |
US6603987B2 (en) | 2000-07-11 | 2003-08-05 | Bayer Corporation | Hollow microneedle patch |
US6358265B1 (en) | 2000-07-18 | 2002-03-19 | Specialized Health Products, Inc. | Single-step disposable safety lancet apparatus and methods |
US6500134B1 (en) | 2000-07-19 | 2002-12-31 | Alphonse Cassone | Method for treating circulatory disorders with acoustic waves |
DE10035911A1 (de) | 2000-07-21 | 2002-02-07 | Abb Research Ltd | Verfahren und Sensor zum Überwachen von Flüssigkeiten |
US6558624B1 (en) | 2000-07-25 | 2003-05-06 | General Electric Company | Method and analytical system for rapid screening of combinatorial libraries |
US7998746B2 (en) | 2000-08-24 | 2011-08-16 | Robert Otillar | Systems and methods for localizing and analyzing samples on a bio-sensor chip |
US6520973B1 (en) | 2000-08-30 | 2003-02-18 | Ethicon Endo-Surgery, Inc. | Anastomosis device having an improved needle driver |
JP4536890B2 (ja) | 2000-09-12 | 2010-09-01 | テルモ株式会社 | 成分測定装置用チップおよび成分測定システム |
US20020045243A1 (en) | 2000-09-15 | 2002-04-18 | Laska Ronald C. | Fluid cartridge and method |
DE10047419A1 (de) * | 2000-09-26 | 2002-04-11 | Roche Diagnostics Gmbh | Lanzettensystem |
US6555061B1 (en) * | 2000-10-05 | 2003-04-29 | Lifescan, Inc. | Multi-layer reagent test strip |
US6537243B1 (en) * | 2000-10-12 | 2003-03-25 | Abbott Laboratories | Device and method for obtaining interstitial fluid from a patient for diagnostic tests |
EP1203563A3 (de) | 2000-10-31 | 2004-01-02 | Boehringer Mannheim Gmbh | Analytisches Hilfsmittel mit integrierter Lanzette |
DE10057832C1 (de) | 2000-11-21 | 2002-02-21 | Hartmann Paul Ag | Blutanalysegerät |
JP4409753B2 (ja) | 2000-12-04 | 2010-02-03 | テルモ株式会社 | 体液測定装置 |
GB0030929D0 (en) | 2000-12-19 | 2001-01-31 | Inverness Medical Ltd | Analyte measurement |
ATE501666T1 (de) | 2000-12-21 | 2011-04-15 | Insulet Corp | Medizinisches gerät zur fernbedienung und verfahren |
AU2002247008B2 (en) | 2001-01-22 | 2006-02-09 | F. Hoffmann-La Roche Ag | Lancet device having capillary action |
USD450711S1 (en) | 2001-01-25 | 2001-11-20 | Digeo, Inc. | User interface for a television display screen |
US6530892B1 (en) * | 2001-03-07 | 2003-03-11 | Helen V. Kelly | Automatic skin puncturing system |
US20020160520A1 (en) | 2001-03-16 | 2002-10-31 | Phoenix Bioscience | Silicon nano-collection analytic device |
US7310543B2 (en) | 2001-03-26 | 2007-12-18 | Kumetrix, Inc. | Silicon microprobe with integrated biosensor |
US6896850B2 (en) * | 2001-03-26 | 2005-05-24 | Kumetrix, Inc. | Silicon nitride window for microsampling device and method of construction |
KR100893275B1 (ko) | 2001-03-29 | 2009-04-17 | 라이프스캔 스코트랜드 리미티드 | 일체식 샘플 시험용 계측기 |
EP1411820A2 (en) | 2001-04-06 | 2004-04-28 | B. Braun Medical, Inc. | Blood testing device |
US20020183102A1 (en) | 2001-04-21 | 2002-12-05 | Withers James G. | RBDS method and device for processing promotional opportunities |
US6783502B2 (en) | 2001-04-26 | 2004-08-31 | Phoenix Bioscience | Integrated lancing and analytic device |
US6748250B1 (en) | 2001-04-27 | 2004-06-08 | Medoptix, Inc. | Method and system of monitoring a patient |
US6712792B2 (en) | 2001-05-02 | 2004-03-30 | Becton, Dickinson And Company | Flashback blood collection needle |
US6753187B2 (en) | 2001-05-09 | 2004-06-22 | Lifescan, Inc. | Optical component based temperature measurement in analyte detection devices |
WO2002093144A1 (en) | 2001-05-10 | 2002-11-21 | Regents Of The University Of Minnesota | Imaging of biological samples using electronic light detector |
US6591124B2 (en) | 2001-05-11 | 2003-07-08 | The Procter & Gamble Company | Portable interstitial fluid monitoring system |
US20030105961A1 (en) | 2001-11-30 | 2003-06-05 | Peter Zatloukal | Avoiding attachment of an ineligible smart interchangeable cover to an electronic device |
US6549796B2 (en) | 2001-05-25 | 2003-04-15 | Lifescan, Inc. | Monitoring analyte concentration using minimally invasive devices |
ES2315961T3 (es) * | 2001-06-08 | 2009-04-01 | F. Hoffmann-La Roche Ag | Dispositivo de extraccion de muestras de fluido corporal. |
US20020188223A1 (en) | 2001-06-08 | 2002-12-12 | Edward Perez | Devices and methods for the expression of bodily fluids from an incision |
US7316700B2 (en) | 2001-06-12 | 2008-01-08 | Pelikan Technologies, Inc. | Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties |
CA2448681C (en) | 2001-06-12 | 2014-09-09 | Pelikan Technologies, Inc. | Integrated blood sampling analysis system with multi-use sampling module |
US6793632B2 (en) | 2001-06-12 | 2004-09-21 | Lifescan, Inc. | Percutaneous biological fluid constituent sampling and measurement devices and methods |
US7025774B2 (en) * | 2001-06-12 | 2006-04-11 | Pelikan Technologies, Inc. | Tissue penetration device |
JP4272051B2 (ja) | 2001-06-12 | 2009-06-03 | ペリカン テクノロジーズ インコーポレイテッド | 血液試料採取装置及び方法 |
DE10128956A1 (de) | 2001-06-15 | 2003-01-02 | Juergen Schomakers | Tablettenstange zur therapiegerechten Individualdosierung |
US7011630B2 (en) | 2001-06-22 | 2006-03-14 | Animas Technologies, Llc | Methods for computing rolling analyte measurement values, microprocessors comprising programming to control performance of the methods, and analyte monitoring devices employing the methods |
US20030208113A1 (en) | 2001-07-18 | 2003-11-06 | Mault James R | Closed loop glycemic index system |
US6766817B2 (en) | 2001-07-25 | 2004-07-27 | Tubarc Technologies, Llc | Fluid conduction utilizing a reversible unsaturated siphon with tubarc porosity action |
US20030028087A1 (en) * | 2001-08-01 | 2003-02-06 | Yuzhakov Vadim Vladimirovich | Devices for analyte concentration determination and methods of using the same |
US20030028125A1 (en) * | 2001-08-06 | 2003-02-06 | Yuzhakov Vadim V. | Physiological sample collection devices and methods of using the same |
US20030039587A1 (en) | 2001-08-22 | 2003-02-27 | Volker Niermann | Transfer device |
JP2005501591A (ja) | 2001-08-29 | 2005-01-20 | エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト | 体液をサンプリングする際に使用するための滲出方法および構造体 |
WO2003025559A1 (fr) | 2001-09-11 | 2003-03-27 | Arkray, Inc. | Instrument de mesure, corps d'installation et mesureur de densite |
US7163616B2 (en) * | 2001-09-14 | 2007-01-16 | Bayer Corporation | Reagents and methods for detecting analytes, and devices comprising reagents for detecting analytes |
JP4320255B2 (ja) | 2001-09-26 | 2009-08-26 | エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト | 体液を採取するための携帯型器具 |
CA2500452A1 (en) | 2001-09-28 | 2003-04-03 | Biovalve Technologies, Inc. | Switchable microneedle arrays and systems and methods relating to same |
JP2003108679A (ja) | 2001-09-28 | 2003-04-11 | Toshiba Corp | 在宅療養者支援システムおよび方法 |
US6689100B2 (en) | 2001-10-05 | 2004-02-10 | Becton, Dickinson And Company | Microdevice and method of delivering or withdrawing a substance through the skin of an animal |
US7291126B2 (en) | 2001-11-26 | 2007-11-06 | Nilimedix Ltd. | Drug delivery device and method |
WO2003061453A2 (en) | 2001-12-04 | 2003-07-31 | Lifepoint, Inc. | Device and method for the identification of analytes in bodily fluids |
EP1627662B1 (en) | 2004-06-10 | 2011-03-02 | Candela Corporation | Apparatus for vacuum-assisted light-based treatments of the skin |
DE10257439A1 (de) | 2001-12-21 | 2003-09-18 | Seiko Instr Inc | Tragbares elektronisches Gerät |
JP3887228B2 (ja) | 2001-12-21 | 2007-02-28 | セイコーインスツル株式会社 | 腕装着型電子機器の位置調整機能付き装着機構および腕装着型電子機器 |
US20050027182A1 (en) | 2001-12-27 | 2005-02-03 | Uzair Siddiqui | System for monitoring physiological characteristics |
US20030216628A1 (en) | 2002-01-28 | 2003-11-20 | Bortz Jonathan David | Methods and systems for assessing glycemic control using predetermined pattern label analysis of blood glucose readings |
US20030143746A1 (en) * | 2002-01-31 | 2003-07-31 | Sage Burton H. | Self-calibrating body anayte monitoring system |
US7004928B2 (en) | 2002-02-08 | 2006-02-28 | Rosedale Medical, Inc. | Autonomous, ambulatory analyte monitor or drug delivery device |
DE20213607U1 (de) | 2002-02-21 | 2003-07-03 | Hartmann Paul Ag | Blutanalysegerät zur Bestimmung eines Analyten |
US7179654B2 (en) | 2002-03-18 | 2007-02-20 | Agilent Technologies, Inc. | Biochemical assay with programmable array detection |
US7175642B2 (en) | 2002-04-19 | 2007-02-13 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
US7892183B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
US7141058B2 (en) | 2002-04-19 | 2006-11-28 | Pelikan Technologies, Inc. | Method and apparatus for a body fluid sampling device using illumination |
US7226461B2 (en) | 2002-04-19 | 2007-06-05 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with sterility barrier release |
US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
US6743635B2 (en) | 2002-04-25 | 2004-06-01 | Home Diagnostics, Inc. | System and methods for blood glucose sensing |
US6847451B2 (en) | 2002-05-01 | 2005-01-25 | Lifescan, Inc. | Apparatuses and methods for analyte concentration determination |
US20030207441A1 (en) | 2002-05-01 | 2003-11-06 | Eyster Curt R. | Devices and methods for analyte concentration determination |
US20030211617A1 (en) | 2002-05-07 | 2003-11-13 | International Business Machines Corporation | Blood glucose meter that reminds the user to test after a hypoglycemic event |
US20030212344A1 (en) | 2002-05-09 | 2003-11-13 | Vadim Yuzhakov | Physiological sample collection devices and methods of using the same |
US7343188B2 (en) | 2002-05-09 | 2008-03-11 | Lifescan, Inc. | Devices and methods for accessing and analyzing physiological fluid |
US20030211619A1 (en) | 2002-05-09 | 2003-11-13 | Lorin Olson | Continuous strip of fluid sampling and testing devices and methods of making, packaging and using the same |
US20030143113A2 (en) * | 2002-05-09 | 2003-07-31 | Lifescan, Inc. | Physiological sample collection devices and methods of using the same |
US7303726B2 (en) | 2002-05-09 | 2007-12-04 | Lifescan, Inc. | Minimal procedure analyte test system |
GB2389419B (en) | 2002-06-05 | 2006-02-22 | Diabetes Diagnostics Inc | Analyte testing device |
US20040232180A1 (en) | 2003-05-19 | 2004-11-25 | Paul Badillo | Belt clip and locking fastener for selectively securing an electronic device |
US20040010207A1 (en) | 2002-07-15 | 2004-01-15 | Flaherty J. Christopher | Self-contained, automatic transcutaneous physiologic sensing system |
GB2393356B (en) | 2002-09-18 | 2006-02-01 | E San Ltd | Telemedicine system |
US7572237B2 (en) | 2002-11-06 | 2009-08-11 | Abbott Diabetes Care Inc. | Automatic biological analyte testing meter with integrated lancing device and methods of use |
US20060184189A1 (en) | 2002-11-15 | 2006-08-17 | Lorin Olson | Cap for a dermal tissue lancing device |
US7334714B2 (en) | 2002-11-18 | 2008-02-26 | Callkeeper Company, Inc. | Wearable personal item carrier |
US20050038680A1 (en) | 2002-12-19 | 2005-02-17 | Mcmahon Kevin Lee | System and method for glucose monitoring |
EP1479344A1 (en) | 2003-05-22 | 2004-11-24 | Roche Diagnostics GmbH | Direct monitoring of interstitial fluid composition |
AU2003297853A1 (en) | 2002-12-24 | 2004-07-29 | F. Hoffmann-La Roche Ag | A sampling device utilizing biased capillary action |
US20040127818A1 (en) | 2002-12-27 | 2004-07-01 | Roe Steven N. | Precision depth control lancing tip |
US8574895B2 (en) | 2002-12-30 | 2013-11-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
US20040132167A1 (en) | 2003-01-06 | 2004-07-08 | Peter Rule | Cartridge lance |
CN100398062C (zh) | 2003-01-17 | 2008-07-02 | 松下电器产业株式会社 | 生体成分测定装置 |
DE10302501A1 (de) | 2003-01-23 | 2004-08-05 | Roche Diagnostics Gmbh | Vorrichtung und Verfahren zur Aufnahme einer Körperflüssigkeit für Analysezwecke |
WO2004066822A2 (en) | 2003-01-29 | 2004-08-12 | Roche Diagnostics Gmbh | Integrated lancing test strip |
US20060189908A1 (en) | 2003-01-31 | 2006-08-24 | Jay Kennedy | Pelvic traction harness |
US7379167B2 (en) | 2003-02-11 | 2008-05-27 | International Technidyne Corporation | Hemoglobin test strip and analysis system |
US6836678B2 (en) | 2003-02-13 | 2004-12-28 | Xiang Zheng Tu | Non-invasive blood glucose monitor |
US6740800B1 (en) | 2003-02-13 | 2004-05-25 | Robert Felder Cunningham | Portable keyboard tremolo musical instrument |
US7052652B2 (en) | 2003-03-24 | 2006-05-30 | Rosedale Medical, Inc. | Analyte concentration detection devices and methods |
JP2006521555A (ja) | 2003-03-24 | 2006-09-21 | ローズデイル メディカル インコーポレイテッド | 被分析物濃度検出の装置及び方法 |
US20050070819A1 (en) | 2003-03-31 | 2005-03-31 | Rosedale Medical, Inc. | Body fluid sampling constructions and techniques |
US7225008B1 (en) | 2003-05-21 | 2007-05-29 | Isense Corporation | Multiple use analyte sensing assembly |
US7150425B2 (en) | 2003-05-28 | 2006-12-19 | Reelcraft Industries, Inc. | Adjustable reel assembly |
US7374949B2 (en) | 2003-05-29 | 2008-05-20 | Bayer Healthcare Llc | Diagnostic test strip for collecting and detecting an analyte in a fluid sample |
US7258673B2 (en) | 2003-06-06 | 2007-08-21 | Lifescan, Inc | Devices, systems and methods for extracting bodily fluid and monitoring an analyte therein |
DE10325699B3 (de) | 2003-06-06 | 2005-02-10 | Roche Diagnostics Gmbh | System zur Analyse einer zu untersuchenden Probe und Verwendung eines solchen Systems |
US7850621B2 (en) | 2003-06-06 | 2010-12-14 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
US20060241666A1 (en) | 2003-06-11 | 2006-10-26 | Briggs Barry D | Method and apparatus for body fluid sampling and analyte sensing |
US7597793B2 (en) | 2003-06-20 | 2009-10-06 | Roche Operations Ltd. | System and method for analyte measurement employing maximum dosing time delay |
JP4225846B2 (ja) | 2003-06-20 | 2009-02-18 | 株式会社 古栃建設 | 道路除雪方法 |
US7488601B2 (en) | 2003-06-20 | 2009-02-10 | Roche Diagnostic Operations, Inc. | System and method for determining an abused sensor during analyte measurement |
DE10332283A1 (de) | 2003-07-16 | 2005-02-03 | Roche Diagnostics Gmbh | System zur Entnahme von Körperflüssigkeit |
AU2004203280A1 (en) | 2003-07-28 | 2005-02-17 | Bayer Healthcare Llc | Swing Lance with Integrated Sensor |
PL207804B1 (pl) | 2003-07-29 | 2011-02-28 | Htl Strefa Społka Z Ograniczoną Odpowiedzialnością | Przyrząd do nakłuwania |
EP1653849B1 (en) | 2003-08-11 | 2010-10-06 | Pelikan Technologies Inc. | Method and apparatus for body fluid sampling with integrated analyte detecting member |
WO2005018709A2 (en) | 2003-08-20 | 2005-03-03 | Facet Technologies, Llc | Lancing device with replaceable multi-lancet carousel |
EP1663025A4 (en) | 2003-08-20 | 2010-03-24 | Facet Technologies Llc | BLOOD COLLECTION DEVICE |
CN1874720B (zh) | 2003-09-03 | 2010-11-17 | 生命修复国际股份有限公司 | 个人诊断装置 |
JP4312559B2 (ja) | 2003-09-19 | 2009-08-12 | 株式会社フジクラ | センサ内蔵針、検体採取用器具、及び検体検査システム |
US7192061B2 (en) | 2003-10-16 | 2007-03-20 | Martin Judy A | Birthday calendar |
US20050096686A1 (en) | 2003-10-31 | 2005-05-05 | Allen John J. | Lancing device with trigger mechanism for penetration depth control |
US7351228B2 (en) | 2003-11-06 | 2008-04-01 | Becton, Dickinson And Company | Plunger rod for arterial blood collection syringes |
US20050109386A1 (en) | 2003-11-10 | 2005-05-26 | Practical Technology, Inc. | System and method for enhanced thermophotovoltaic generation |
AU157690S (en) | 2003-11-21 | 2005-03-09 | Saika Tech Institute Foundation | Solidus extracting cartridge |
AU157691S (en) | 2003-11-21 | 2005-03-09 | Saika Tech Institute Foundation | Solidus extracting cartridge |
DE102004002874A1 (de) | 2004-01-20 | 2005-08-11 | Roche Diagnostics Gmbh | Analysegerät zur Analyse von Blutproben |
US8403865B2 (en) | 2004-02-05 | 2013-03-26 | Earlysense Ltd. | Prediction and monitoring of clinical episodes |
US20050187532A1 (en) | 2004-02-24 | 2005-08-25 | Medex, Inc. | Diaphragm-based reservoir for a closed blood sampling system |
US8105849B2 (en) | 2004-02-27 | 2012-01-31 | Board Of Regents, The University Of Texas System | Integration of fluids and reagents into self-contained cartridges containing sensor elements |
CN100337589C (zh) | 2004-02-27 | 2007-09-19 | 株式会社日立制作所 | 血糖值测定装置 |
JP2005237938A (ja) | 2004-02-29 | 2005-09-08 | Ogawa Hiroteru | 採血装置ならびに方法 |
WO2005084557A1 (en) | 2004-03-02 | 2005-09-15 | Facet Technologies, Llc | Compact multi-use lancing device |
ES2245586B1 (es) | 2004-03-04 | 2007-08-01 | Universidad De Cadiz | Medidor de flexion de cadera. |
ES2572775T3 (es) | 2004-03-06 | 2016-06-02 | F. Hoffmann-La Roche Ag | Dispositivo para la extracción de líquidos corporales |
DE602004021432D1 (de) | 2004-03-08 | 2009-07-16 | Sergeev Yaroslav | Computersystem zum speichern von unendlichen, infinitisimalen, und endlichen grössen und durchführen von arithmetischen operationen damit |
JP2005257337A (ja) | 2004-03-09 | 2005-09-22 | Brother Ind Ltd | 検査対象受体、検査装置、及び検査方法 |
US20050209518A1 (en) | 2004-03-17 | 2005-09-22 | Therafuse, Inc. | Self-calibrating body analyte monitoring system |
KR20060130657A (ko) | 2004-03-18 | 2006-12-19 | 후지 샤신 필름 가부시기가이샤 | 검체 검사방법에 사용되는 분석요소 |
US20050215923A1 (en) | 2004-03-26 | 2005-09-29 | Wiegel Christopher D | Fingertip conforming fluid expression cap |
JP4944770B2 (ja) | 2004-04-16 | 2012-06-06 | ファセット・テクノロジーズ・エルエルシー | 穿刺装置用のキャップ変位機構及びマルチランセットカートリッジ |
KR20070004887A (ko) | 2004-04-26 | 2007-01-09 | 가부시끼가이샤아사히폴리슬라이더 | 인시젼을 형성하기 위한 란셋 장치 |
US9101302B2 (en) | 2004-05-03 | 2015-08-11 | Abbott Diabetes Care Inc. | Analyte test device |
DE102004024970A1 (de) | 2004-05-21 | 2005-12-08 | Roche Diagnostics Gmbh | Vorrichtung und Verfahren zur Positionierung eines Körperteils |
US7384402B2 (en) | 2004-06-10 | 2008-06-10 | Roche Diagnostics Operations, Inc. | Expression pad |
US7299081B2 (en) | 2004-06-15 | 2007-11-20 | Abbott Laboratories | Analyte test device |
US7727166B2 (en) | 2004-07-26 | 2010-06-01 | Nova Biomedical Corporation | Lancet, lancet assembly and lancet-sensor combination |
US7645241B2 (en) | 2004-09-09 | 2010-01-12 | Roche Diagnostics Operations, Inc. | Device for sampling bodily fluids |
US8211038B2 (en) | 2004-09-17 | 2012-07-03 | Abbott Diabetes Care Inc. | Multiple-biosensor article |
US7380357B2 (en) | 2004-12-03 | 2008-06-03 | Adstracts, Inc. | Promotional badge holding apparatus |
DE102004059491B4 (de) | 2004-12-10 | 2008-11-06 | Roche Diagnostics Gmbh | Lanzettenvorrichtung zum Erzeugen einer Einstichwunde und Lanzettenantriebs-Baugruppe |
RU2400733C2 (ru) | 2004-12-13 | 2010-09-27 | Байер Хелткэр Ллк | Система для спектроскопии пропускания для использования при определении анализируемых веществ в жидкости организма |
JP4595525B2 (ja) | 2004-12-20 | 2010-12-08 | オムロンヘルスケア株式会社 | 血圧計用カフおよびこれを備えた血圧計 |
US8934955B2 (en) | 2005-01-18 | 2015-01-13 | Stat Medical Devices, Inc. | Cartridge with lancets and test strips and testing device using the cartridge |
US20070033074A1 (en) | 2005-06-03 | 2007-02-08 | Medtronic Minimed, Inc. | Therapy management system |
US20060281187A1 (en) | 2005-06-13 | 2006-12-14 | Rosedale Medical, Inc. | Analyte detection devices and methods with hematocrit/volume correction and feedback control |
JP4576626B2 (ja) | 2005-07-05 | 2010-11-10 | 独立行政法人産業技術総合研究所 | 穿刺器具一体型バイオセンサーの製造法 |
US20070017824A1 (en) | 2005-07-19 | 2007-01-25 | Rippeth John J | Biosensor and method of manufacture |
UY29721A1 (es) | 2005-08-05 | 2007-03-30 | Bayer Healthcare Llc | Medidor con alarma de tiempo postprandial para efectuar determinaciones |
US20070093786A1 (en) | 2005-08-16 | 2007-04-26 | Medtronic Minimed, Inc. | Watch controller for a medical device |
JP5005200B2 (ja) | 2005-08-25 | 2012-08-22 | テルモ株式会社 | 穿刺装置及び穿刺針チップ |
US20070060844A1 (en) | 2005-08-29 | 2007-03-15 | Manuel Alvarez-Icaza | Applied pressure sensing cap for a lancing device |
JP4717557B2 (ja) | 2005-08-30 | 2011-07-06 | 三菱電機株式会社 | 通信システムおよび送受信装置 |
US7066890B1 (en) | 2005-08-31 | 2006-06-27 | Lam Phillip L | Combined computer mouse and blood pressure sphygmomanometer |
US7887494B2 (en) | 2005-09-30 | 2011-02-15 | Intuity Medical, Inc. | Fluid sample transport devices and methods |
EP3461406A1 (en) | 2005-09-30 | 2019-04-03 | Intuity Medical, Inc. | Multi-site body fluid sampling and analysis cartridge |
US8801631B2 (en) | 2005-09-30 | 2014-08-12 | Intuity Medical, Inc. | Devices and methods for facilitating fluid transport |
US20070112367A1 (en) | 2005-11-17 | 2007-05-17 | Olson Lorin P | Method for lancing a dermal tissue target site using a cap with revolving body |
US9149215B2 (en) | 2005-12-30 | 2015-10-06 | Roche Diabetes Care, Inc. | Portable analytical device |
US8206318B2 (en) | 2006-03-22 | 2012-06-26 | Panasonic Corporation | Blood test apparatus |
US8285487B2 (en) | 2006-03-23 | 2012-10-09 | Becton, Dickinson And Company | System and methods for improved diabetes data management and use employing wireless connectivity between patients and healthcare providers and repository of diabetes management information |
WO2007116648A1 (ja) | 2006-04-03 | 2007-10-18 | Konica Minolta Medical & Graphic, Inc. | 放射線画像読取装置および診断システム |
US20070255179A1 (en) | 2006-04-27 | 2007-11-01 | Lifescan Scotland, Ltd. | Lancing system with lancing device-integrated light source |
JP2007311196A (ja) | 2006-05-18 | 2007-11-29 | Ritsutoku Denshi Kofun Yugenkoshi | 設置方向を変える電源プラグ |
US20080004601A1 (en) | 2006-06-28 | 2008-01-03 | Abbott Diabetes Care, Inc. | Analyte Monitoring and Therapy Management System and Methods Therefor |
USD551243S1 (en) | 2006-06-30 | 2007-09-18 | Microsoft Corporation | Graphical user interface for a display screen |
CN101489469B (zh) | 2006-07-10 | 2012-12-12 | 埃森哲环球服务有限公司 | 用于提供反馈的移动个人服务平台 |
JP4285704B2 (ja) | 2006-08-16 | 2009-06-24 | ソニー・エリクソン・モバイルコミュニケーションズ株式会社 | 情報処理装置、情報処理方法、及び情報処理プログラム |
USD540343S1 (en) | 2006-08-16 | 2007-04-10 | Microsoft Corporation | Icon for a portion of a display screen |
US8372015B2 (en) | 2006-08-28 | 2013-02-12 | Intuity Medical, Inc. | Body fluid sampling device with pivotable catalyst member |
USD580558S1 (en) | 2006-09-29 | 2008-11-11 | Fujifilm Corporation | Cap of cartridge for component extraction |
USD580068S1 (en) | 2006-09-29 | 2008-11-04 | Fujifilm Corporation | Cap of cartridge for component extraction |
US20080119702A1 (en) | 2006-10-31 | 2008-05-22 | Abbott Diabetes Care, Inc. | Analyte meter having alert, alarm and test reminder capabilities and methods of use |
JP4894039B2 (ja) | 2006-11-21 | 2012-03-07 | 独立行政法人産業技術総合研究所 | バイオセンサカートリッジ及びバイオセンサ装置 |
US20080139910A1 (en) | 2006-12-06 | 2008-06-12 | Metronic Minimed, Inc. | Analyte sensor and method of using the same |
EP1936362B1 (de) | 2006-12-20 | 2020-03-18 | Roche Diabetes Care GmbH | Testelement mit Referenzierung |
US9597019B2 (en) | 2007-02-09 | 2017-03-21 | Lifescan, Inc. | Method of ensuring date and time on a test meter is accurate |
US9186097B2 (en) | 2007-09-17 | 2015-11-17 | Roche Diabetes Care, Inc. | Body fluid lancing, acquiring, and testing cartridge design |
USD599373S1 (en) | 2007-10-31 | 2009-09-01 | Brother Industries, Ltd. | Computer icon image for a portion of a display screen |
USD601578S1 (en) | 2007-12-04 | 2009-10-06 | Somfy Sas | Icon for a portion of a display screen |
JP5816080B2 (ja) | 2008-05-30 | 2015-11-17 | インテュイティ メディカル インコーポレイテッド | 体液採取装置及び採取部位インターフェイス |
USD601257S1 (en) | 2008-05-30 | 2009-09-29 | Intuity Medical, Inc. | Hand-held meter |
USD601444S1 (en) | 2008-05-30 | 2009-10-06 | Intuity Medical, Inc. | Cartridge for use in hand-held meter |
EP2299904B1 (en) | 2008-06-06 | 2019-09-11 | Intuity Medical, Inc. | Medical measurement method |
JP5642066B2 (ja) | 2008-06-06 | 2014-12-17 | インテュイティ メディカル インコーポレイテッド | 体液の試料内に含まれている検体の存在または濃度を決定する検定を行う方法および装置 |
US8551320B2 (en) | 2008-06-09 | 2013-10-08 | Lifescan, Inc. | System and method for measuring an analyte in a sample |
US20100095229A1 (en) | 2008-09-18 | 2010-04-15 | Abbott Diabetes Care, Inc. | Graphical user interface for glucose monitoring system |
USD622393S1 (en) | 2009-06-04 | 2010-08-24 | Intuity Medical, Inc. | Hand-held meter |
US20100331650A1 (en) | 2009-06-25 | 2010-12-30 | Roche Diagnostics Operations, Inc. | Episodic blood glucose monitoring system with an interactive graphical user interface and methods thereof |
EP2493535A2 (en) | 2009-10-30 | 2012-09-05 | Seventh Sense Biosystems, Inc. | Systems and methods for application to skin and control of actuation, delivery and/or perception thereof |
EP2506768B1 (en) | 2009-11-30 | 2016-07-06 | Intuity Medical, Inc. | Calibration material delivery devices and methods |
US8391940B2 (en) | 2010-02-04 | 2013-03-05 | Lifescan, Inc. | Methods and systems to correct for hematocrit effects |
USD642191S1 (en) | 2010-06-24 | 2011-07-26 | Microsoft Corporation | Display screen with transitional user interface |
USD654926S1 (en) | 2010-06-25 | 2012-02-28 | Intuity Medical, Inc. | Display with a graphic user interface |
US10330667B2 (en) | 2010-06-25 | 2019-06-25 | Intuity Medical, Inc. | Analyte monitoring methods and systems |
TW201206400A (en) | 2010-07-08 | 2012-02-16 | Sanofi Aventis Deutschland | Allowing measurements to be made of a blood sample |
US20130110516A1 (en) | 2010-11-05 | 2013-05-02 | Prodigy Diabetes Care, Llc | Vessel such as a pill bottle with contents describing voice storing and reproducing means and method |
CA2843945C (en) | 2011-08-03 | 2022-06-21 | Intuity Medical, Inc. | Devices and methods for body fluid sampling and analysis |
WO2013156526A1 (de) | 2012-04-19 | 2013-10-24 | F. Hoffmann-La Roche Ag | Verfahren und vorrichtung zur bestimmung einer analytkonzentration in blut |
JP2016522070A (ja) | 2013-06-21 | 2016-07-28 | インテュイティ メディカル インコーポレイテッド | 可聴フィードバックを用いた分析物モニタリングシステム |
WO2018191700A1 (en) | 2017-04-13 | 2018-10-18 | Intuity Medical, Inc. | Systems and methods for managing chronic disease using analyte and patient data |
-
2002
- 2002-04-23 US US10/131,268 patent/US7004928B2/en not_active Expired - Lifetime
-
2003
- 2003-02-07 CA CA2476308A patent/CA2476308C/en not_active Expired - Lifetime
- 2003-02-07 JP JP2003565550A patent/JP4856849B2/ja not_active Expired - Lifetime
- 2003-02-07 EP EP11195415.2A patent/EP2471570B1/en not_active Expired - Lifetime
- 2003-02-07 AU AU2003215064A patent/AU2003215064A1/en not_active Abandoned
- 2003-02-07 EP EP03710880.0A patent/EP1480710B1/en not_active Expired - Lifetime
- 2003-02-07 EP EP11195925A patent/EP2471571A3/en not_active Ceased
- 2003-02-07 WO PCT/US2003/003536 patent/WO2003066128A2/en active Application Filing
- 2003-02-07 DK DK03710880.0T patent/DK1480710T3/en active
-
2005
- 2005-12-20 US US11/311,667 patent/US8303518B2/en active Active
-
2010
- 2010-06-23 JP JP2010143116A patent/JP2010279704A/ja active Pending
-
2012
- 2012-11-05 US US13/669,366 patent/US9603562B2/en not_active Expired - Lifetime
-
2017
- 2017-03-22 US US15/466,684 patent/US10772550B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO2003066128A3 (en) | 2003-12-11 |
US9603562B2 (en) | 2017-03-28 |
US20170319121A1 (en) | 2017-11-09 |
JP2005525149A (ja) | 2005-08-25 |
AU2003215064A1 (en) | 2003-09-02 |
EP2471570B1 (en) | 2018-11-07 |
DK1480710T3 (en) | 2017-07-03 |
CA2476308C (en) | 2011-04-26 |
EP1480710A2 (en) | 2004-12-01 |
EP2471571A3 (en) | 2012-09-26 |
AU2003215064A8 (en) | 2003-09-02 |
US8303518B2 (en) | 2012-11-06 |
EP2471570A3 (en) | 2012-09-26 |
WO2003066128A2 (en) | 2003-08-14 |
EP1480710A4 (en) | 2008-06-25 |
JP2010279704A (ja) | 2010-12-16 |
EP2471570A2 (en) | 2012-07-04 |
EP2471571A2 (en) | 2012-07-04 |
US10772550B2 (en) | 2020-09-15 |
US20030153900A1 (en) | 2003-08-14 |
EP1480710B1 (en) | 2017-05-17 |
US7004928B2 (en) | 2006-02-28 |
US20130158430A1 (en) | 2013-06-20 |
CA2476308A1 (en) | 2003-08-14 |
US20060094985A1 (en) | 2006-05-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP4856849B2 (ja) | 自律携帯式検体監視装置又は薬剤送給装置 | |
US8224410B2 (en) | Dermally affixed sensor device | |
JP6078565B2 (ja) | 皮膚に適用される比較的小型のデバイス | |
US7343188B2 (en) | Devices and methods for accessing and analyzing physiological fluid | |
JP5784031B2 (ja) | 皮膚に適用される比較的小型のデバイス、モジュラーシステム、およびその使用方法 | |
US20080200838A1 (en) | Wearable, programmable automated blood testing system | |
US20070123801A1 (en) | Wearable, programmable automated blood testing system | |
CN102006821A (zh) | 用于模块化分析物监测的设备、系统和方法 | |
US10010274B2 (en) | Systems, devices and methods for in situ calibration of implantable sensors | |
Brooker | The artificial pancreas |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20060116 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20060116 |
|
RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20060802 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090203 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20090428 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20090511 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20090803 |
|
RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20090803 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20100223 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100623 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20100805 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20100825 |
|
A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20101001 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20110629 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20110704 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20110729 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20110803 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110826 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20111031 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20141104 Year of fee payment: 3 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 4856849 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
EXPY | Cancellation because of completion of term |