JP2005525149A - 自律携帯式検体監視装置又は薬剤送給装置 - Google Patents
自律携帯式検体監視装置又は薬剤送給装置 Download PDFInfo
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Abstract
Description
図1は本発明による検体監視装置、又はドラグ(薬剤)送給装置10の一部を絵画的な線図で示している。この装置はハウジング(下部のみを示す)12を有し、キャリヤ16上に配置された複数個のマイクロニードル14と、電子部分18とをこのハウジングが包囲している。キャリヤ16は図1に示すように、円形輪郭を有するほぼ平坦な基材である。キャリヤ16は本発明の範囲内において、種々の幾何学形状に形成し得ることは明らかである。
3つの例示のシステムモジュールは使用者が使い易いこと、診断上の関係、安価な検体監視、薬剤送給のシステムの要求に最適に整合するように特定されている。検体監視、及び薬剤送給システムは使い捨てモジュール、再使用可能モジュール、及びPDAモジュールに区分されている。例えば、図27を参照されたい。この形態は確実な利点を達成するため、これ等3つの形態の中で機能を最適に分散させている。しかし、本発明はこの形態に限定されない。例えば、全ての電子工学部品、マイクロニードル、化学物質、機械的部品、及び使用者インタフェースを含む一ユニットの使い捨て装置を代案として採用してもよい。又は、最も適切には、本発明の設計により、1個、又はそれ以上のシステムモジュール間に、構成部分をどのようにでも分散させることができる。例えば、全体のシステム費用、使用者の安全性、及び/又は性能の関心に基づいて、1個、又はそれ以上のシステムモジュールの中で、構成部分を区分することができる。
このモジュールには一度使用して、生物学的安全性と、診断の正確性とを維持するため、廃棄しなければならない構成部分を含んでいる。このモジュールには、完全性、滅菌性、及びいかなる再使用可能な構成部分へのインタフェースをも維持するための構造素子、又は機械的素子をも含んでいるのが好適である。従って、このシステムモジュールにはマイクロニードル、マイクロ流体組立体、隔膜、試薬の化学、及び関連ハウジング材料を含むのが好適である。また、このモジュールは身体に密着し、その密着を維持するための保持機構を含むことができ、これにより検体の監視システム、及び薬剤送給システムの機械的な保持を行う。
このモジュールは制御、運動の自動化、グルコース反応の測定、使用者への警告、PDAモジュールへのデータの転送を行う構成部分を含んでいるのが好適である。また、このモジュールは身体への密接を達成し、その維持のための保持機構を含んでいて、検体監視システム、及び薬剤送給システムのための機械的保持を行う。また、このモジュールは関連する回路(例えば電子工学に対応する記憶装置)を有するマイクロプロセッサ、何かの反応(例えばグルコース反応)の生成物を判断するためのセンサ(例えば電子工学センサ)、モータ等の駆動機構、センサ、電源(例えば電池)36、及び可搬式計算装置、又はPDAに通信するように作用するインタフェースを有しているのが好適である。このインタフェースはRF、磁気的、誘導的、光学的等なものにすることができる。RF結合を使用するよりも、磁気結合、又は誘導結合を使用するのが有利であり、それは後者の方がFCC制約、又は制限を避ける可能性があるためである。また、再使用可能モジュールには使用者の行動に干渉を必要とすることを使用者に知らせるための音響による、又は振動による警報手段を有することもできる。
このモジュールにはこの装置を制御し、及び/又はこの装置に相互に作用し合うためのパーソナルディジタルアシスタント(PDA)、手で持つことができるコンピュータのような可搬式コンピュータ装置を介する別個の使用者インタフェースを有するのが好適である。代表的な可搬式コンピュータ装置としては、プロセッサ、メモリ、関連する回路、ディスプレイ(例えば、単色ディスプレイ、又はカラー液晶ディスプレイ)、及びキーパッドのような入力装置、タッチスクリーン(例えばディスプレイと一体のもの)等、及び作動システムがある。以前に入手可能であったグルコースモニタはペーパ試験条片を取り扱うため、グルコース測定値の数値を見るため、及びそのキャリブレーションのようにメータの他のパラメータを設定するため特に設計されたものである。これ等の顧客向けに設計されたユニットは機能が制約されており、使用者のインタフェースが不十分であった。
本発明は注射、又は血液の採取に、今日、最も多く使用される針よりも一層小さい針であって、ここでマイクロニードルと称するニードルを突出させるように作動する機構を包含する。マイクロニードルを使用すれば、最少の不快感、又は最少の苦痛で血液を抽出することができる。蚊に例えられるこのマイクロニードルによる血液の抽出は有効であることが注目されている。ミクロンの太さの中空部材を通じて、血液を引き出している間、基本的に苦痛無く、血液を抽出するという人間ではできないことを行うように、この昆虫、即ちマイクロニードルは管理されている。
種々のセンサ構造を本発明では使用することができる。例えば比色分析、及び蛍光発光のような技術によって、光学的検出を行うことができる。図16はマイクロニードル514に流体連通しているマイクロチャネル520、及び反応層521を有する基本形態を示している。反応層を隔膜にすることができ、この隔膜には化学的に活性な成分をコーティングし、比色分析の測定のため、希望する検体(例えば、グルコース)の存在の場合に、この活性成分によって色を変化させる。マイクロニードル514を通じて、流体試料を捕集し、マイクロチャネル520内に保管する。適切な試薬をマイクロチャネル520内に収容するのが好適であり、これにより、流体試料を捕集すると、反応を開始する。マイクロチャネル520の上方にセンサを配置し、このセンサは適切な周波数の光で反応層を照射するように作用するエミッタ535を有する。また、このセンサは矢印539によって示すように、反応層から反射する光を検出するように作用する検出器537を有する。この検出器537は単一、又は複数の画像素子(ピクセル)を有する光ダイオードを使用して作動する。このような装置の例はCMOS、又はCCDイメージャがある。エミッタ、及び検出器はプロセッサ(図示せず)によって、制御されるのが良い。検出器の出力はこのプロセッサによって読み取られるのが好適であり、反応の結果を決定するため、更に処理される。図17a、及び図17bは感度を高めるため増強された捕集形態を示す。このセンサ形態には1個、又はそれ以上の個数のエミッタ535から、検出器537まで光を反射するための球状ミラー541を有する。
本発明は血液の捕集を強化するための種々の技術を有する。図20a、及び図20bは捕集位置に近い組織を加熱するための加熱源(例えば赤外線放出LED)の使用を示す。捕集位置で組織の毛細血管組織を加熱することによって、血液の供給を向上させ、マイクロニードルを使用する血液の捕集を増大する。図20aは皮膚、又は組織に挿入された例示のマイクロニードル514を示す。加熱源598をマイクロニードルの一側に設置して、組織に指向させ、これにより、マイクロニードルを挿入した組織を加熱する。図20bは代案の実施例を示し、加熱源599はほぼ環状であり、マイクロニードル514の周りに同軸に設置されている。
血液の捕集を簡単化し、十分な試料を得ることを確実にするため、本発明は血液検出センサの使用を包含する。この血液検出センサは貫入と抽出とについての制御を提供する。このセンサのフィードバックループはマイクロニードルを皮膚の中に少しづつ駆動することによって作動し、血液がマイクロニードルを充たすための適切な時間を待って、次にセンサはマイクロニードルを後退させる。図21を参照されたい。妥当な時間内に血液が検出されないと、モータはマイクロニードルを一層深い深さまで、更に駆動する。血液が得られると、マイクロニードルを後退させる。
1987年以来、米国糖尿病協会(ADA)は自己管理血糖値(SMBG)メータの統計上の査定のための判定基準を提供している。1987年には、血糖値の測定値は基準値の15%以内であるべきこと、及び将来のSMBGメータの変動値が10%以下であるべきことをADAが推薦した。1993年までに、この当時の新しい技術では1987年の目標を達成できないことが明らかになった。しかし、1996年には、ADAは将来のSMBGメータに対し5%以下の変動値を推薦した。
ベータ−D−グルコース+O2 +H2O =D−グルコン酸+H2O2 (1)
2H2O+4−アミノアンチピリン+1.7−ジヒドロキシナフタリン=赤色色素 (2)
この反応は第1反応に関して、酸化酵素が存在しており、第2反応に関して、ペルオキシダーゼが存在している状態で発生する。トリンダー反応はグルコース検査のために広く使用されている。トリンダー反応の重要な特徴は使用の長い歴史があること、上昇した温度で染色先駆物質の安定性、酵素の入手容易性と、酵素の熱に対する安定性である。1.7 −ジヒドロキシナフタリンはアルコールのみに溶性であり、水溶性の芳香性が好適である。この芳香性物質はDeluca等に与えられた米国特許第4350762 号に特定している水溶性試薬の一つが好適であり、例えば、2.4-ジクロロフェニルスルホン酸塩のナトリウム塩である。
酵素試験の精度を向上させるため、正しい結果を一層正確に決定するために使用すべき補正因子であるキャリブレーションファクタとして、試験条片の各バッチを現在のSMBGメータに設けることは助けになることがわかった。2つのキャリブレーションが必要であり、その第1は機器の構成部分を補正することであり、第2は化学的成分の特定の特別な感度を補正することである。このことを自動的に達成するため、種々の技術が開発されている。
本発明は必ずしもこれに限定されないが、酵素、抗体、アルコールレベル、その他の血液成分を含む種々の成分を試験するのに利用することができる。本発明はまたHbAlc (糖化ヘモグロビン)血液試験を組み込むように設計することができ、この試験は1年に2回、又はそれ以上行うべき糖尿病の試験であり、この試験は血糖値レベルを調整するのに長期間にわたり有効な手段を提供する。実際上、体温で、又は体温付近で使用し得る化学反応を有する血液試験はこのシステムに組み込むことができる。また、本発明は血液内の異物体を遺伝学的に確認するポリメラーゼ連鎖反応(PCR)試験を提供し得ると考えられる。二重核酸の熱融解を利用する試験に、比較的小さな加熱素子を使用することができる。包囲する構造の加熱を最小にするため、絶縁を使用することもできる。
本明細書を展望すれば、選択された例により、種々の比色分析法、電気化学的検査法、及び蛍光発光検査法を利用し得ることを示している。これ等の方法の中で、Zanzucchi に与えられた米国特許第6118126 号は蛍光発光検査技術を開示しており、本発明の装置のための代わりの検査方法として使用することもできる。この技術は織目加工された表面からの蛍光発光を増大させる。本発明に関連して、増大した蛍光発光は小さな試料の検査の感度を向上させる。本発明の範囲を逸脱することなく、種々の他の検査技術を使用し得ることは明らかである。
このシステムを使用者に親しみ易くするため、神経回路網のような人口知能構想を使用する単一学習アルゴリズムをこのシステムのコンピュータによって使用することができる。このアルゴリズムは多数の血液採取の歴史的なデータから、個々に特殊なパラメータを推論することができる。これ等の付加的な可変値は身体上の位置、最終の食事からの時間、最終の運動からの時間、日時である(毛細血管は日中、特に肉体的な活動の時間の間、一層血液に富んでいる)。これ等のデータを使用して、血液を採取できる可能性を推察し、従って、最適のマイクロニードル深さ、及びそのままにしておく時間を推察する。
不承諾の主要な理由の一つはグルコースの測定と、補償作用との間に緊密なフィードバックループがないことである。本発明はグルコースレベルの読み取りだけでなく、多少ともインシュリン、又は口経薬品、又は栄養補助食品に関する提言を行うことができる。
自動化された糖尿病管理ソフトウェアは以前から開発されており、血糖値レベルを制御する糖尿病患者を助けているが、形式の複雑なこと、及び一層多くの読み取りが不適切なため、大部分が失敗している。糖尿病管理ソフトウェアは糖尿病薬の調剤、又は食事の編成を変更し、高血糖症、又は低血糖症の発生を最少にする。これ等のシステムは各個人の血糖値が若干のレベルの干渉によってどのように変化するかを正確に予測するためには、長い歴史的な、またリアルタイムのデータが必要である。不幸にして、これ等のシステムは失敗しており、それは使用者の状態、及び生理学上の応答があまりにも予測できず、リアルタイムの血糖値の測定値に基づく短期間の予測のみが結果を変更するのを助けるのに使用できるだけである。
本発明は分離した場所に装着するから、グルコース値を決定するために装着したまま、物理的に、又は視覚的にアクセスしなければならない使用者にとって不便であるかもしれない。従って、使用者のグルコース値が決定値を越えつつあるか、一層低い所定レベルより下になっているかを決定するため、使用者が常にPDAに問いただす必要があってはならない。再使用可能ユニットに、直接通信するように変更し、Palm、又はHandspringによって生産されたような無線のパーソナルディジタルアシスタントを使用することは一層便利で、人間工学的に、そして社会的に受け入れられる。
融通性のある試験スケジュールのため、システムソフトウェアに、タイミングシステムを組み込むのが好適である。上に述べたように、使用者がそのグルコース値を試験しなければならない時、及び使用者が変わったため上限、下限を設定するため、使用者は時間をプログラミングすることができる。使用者が変更を行い、使用者からの確認があった場合、この情報がシステムに無線でダウンロードされるのが好適である。日中は、使用者はグルコース値の読み取りをチェックするようにシステムによって警告されない限り、PDAを使用する必要はない。使用者が直ちに測定を行うことを希望すれば、使用者はPDAから試験を開始することができる。使用者が一旦、この指令を選択し、それを確認し、それを再使用可能ユニットに転送すれば、PDAに対して確認が行われる。
本発明は身体上の種々の位置に、装置を設置する能力を有する。図28は本発明装置を設置するための身体上の例示の位置を絵画的に示す線図である。
Claims (59)
- 対象物から流体試料を引き出すように作動し得る検体監視装置において、
第1の複数個のマイクロニードルと、
複数個の監視マイクロチャネルであって、前記第1の複数個のマイクロニードルのおのおのが対応する監視マイクロチャネルに少なくとも間欠的に流体連通しており、各前記監視マイクロチャネルが試薬に関連している複数個の監視マイクロチャネルと、
前記対象物から前記流体試料を引き出すため、各マイクロニードルを突出させるように作動し得る少なくとも1個のアクチュエータと、
前記流体試料の検体試験を開始するように作動し得る制御器とを具えることを特徴とする検体監視装置。 - 前記アクチュエータは前記第1の複数個のマイクロニードルの少なくとも1個を全方向に突出させるように作動可能である請求項1の装置。
- 前記第1の複数個のマイクロニードルのおのおのが約25〜200ミクロンの範囲の内径を有している請求項1の装置。
- 前記第1の複数個のマイクロニードルのおのおのが、金属、プラスチック、ガラス、及び結晶体のうちの少なくとも一つから製造されている請求項1の装置。
- 前記第1の複数個のマイクロニードルのおのおのが、最大約2.5 mmまで、皮膚の表面内に貫入するよう作動し得る末端を有する請求項1の装置。
- 前記流体試料が実質的に血液である請求項1の装置。
- 前記第1の複数個のマイクロニードルのおのおのが導管を通じて、監視マイクロチャネルに少なくとも間欠的に流体連通している請求項1の装置。
- 各監視マイクロチャネルは前記流体試料を貯蔵するように作動可能であり、前記監視マイクロチャネル内の前記流体試料の蓄積は毛管力に全く依存している請求項1の装置。
- 毛管力を増大し、凝固を最少にするように、少なくとも1個の不溶性材料を少なくとも一部にコーティングした少なくとも1個の内面を前記監視マイクロチャネルのおのおのが有する請求項1の装置。
- 前記複数個の監視マイクロチャネルが一群のものとして製作されている請求項1の装置。
- 前記監視マイクロチャネルはほぼ5cmの最大直径内に形成されたほぼ50〜150個のマイクロチャネルを有する一群のものとして製作されている請求項1の装置。
- 前記第1の複数個のマイクロニードルのおのおのは50〜500ナノリットルの範囲内の流体の容積のために、寸法が定められている請求項1の装置。
- 前記流体試料が少なくとも1個の監視マイクロチャネルを完全に充填して、関連する前記マイクロニードルによって前記流体試料の蓄積が終了し得る時を決定するように作動し得る検出器を具える請求項1の装置。
- (a)グルコース、(b)コレステロール、(c)エタノール、(d)ジコキシン、(e)HDLコレステロール、(f)リチウム、(g)ナトリウム、(h)フェニトイン、(i)セロフィリン、(j)サイクロスポリン、(k)癌化学療法薬、(l)DNA、(m)RNA、(n)増量フェニトインナトリウム、(o)ワルファリンナトリウム、及び(p)血液から生じた蛋白質の群から選択された検体のための検査をするように作用し得る少なくとも1個の試薬に、少なくとも1個の監視マイクロチャネルが流体連通している請求項1の装置。
- 単一のマイクロニードルを使用して、多数の検査を行えるよう、少なくとも2個の監視マイクロチャネルを単一のマイクロニードルに関連させた請求項1の装置。
- 第2の複数個のマイクロニードルと、キャリブレーション流体を充填した複数個のキャリブレーションマイクロチャネルとを具え、キャリブレーションの目的で、少なくとも1個の検査を開始する請求項1の装置。
- 第3の複数個のマイクロニードルと、複数個の薬剤送給マイクロチャネルとを具え、各薬剤送給マイクロチャネルには少なくとも一部、薬剤を充填した請求項1の装置。
- 少なくとも1個の監視マイクロチャネルをポリマでシールした請求項1の装置。
- 前記制御器はタイムスケジュールに基づいて、検体試験を開始するように作動可能である請求項1の装置。
- 前記制御器は検体試験タイムスケジュールを調整するように作動可能である請求項19の装置。
- 前記制御器は可搬式コンピュータ装置を結合するように作動可能である請求項1の装置。
- 前記可搬式コンピュータ装置がPDAである請求項21の装置。
- 前記制御器、及び前記可搬式コンピュータ装置の少なくとも一方が検体試験の時間を選択し、又は変更するように作動可能である請求項21の装置。
- 前記複数個のマイクロニードル、及び複数個の監視マイクロチャネルが使い捨てである請求項1の装置。
- 前記制御器、及び前記アクチュエータが再使用可能である請求項1の装置。
- 前記複数個のマイクロニードル、複数個の監視マイクロチャネル、アクチュエータ、及び制御器が可搬式である請求項1の装置。
- マイクロニードルを突出させる前に、少なくとも1個の注射位置を加熱するように作動し得る加熱源を具える請求項1の装置。
- 前記加熱源が光学加熱源である請求項27の装置。
- ハウジングを表面に取り付けるように作用し得る接着剤を少なくとも一部、コーティングしたハウジングを具え、前記複数個のマイクロニードル、及び前記監視マイクロチャネルを前記ハウジングが少なくとも一部、包囲している請求項1の装置。
- 前記複数個のマイクロニードル、及び前記監視マイクロチャネルを少なくとも一部包囲するほぼディスク状のハウジングを具える請求項1の装置。
- 対象物に薬剤を送給するように作動し得る薬剤送給装置において、
第1の複数個のマイクロニードルと、
複数個の薬剤送給マイクロチャネルであって、前記第1の複数個のマイクロニードルのおのおのが対応する薬剤送給マイクロチャネルに少なくとも間欠的に流体連通しており、各薬剤送給マイクロチャネルが少なくとも一部、薬剤を充填されている複数個の薬剤送給マイクロチャネルと、
前記対象物に前記薬剤を送給するため、各マイクロニードルを突出させるように作動し得る少なくとも1個のアクチュエータと、
前記薬剤の送給を開始するように作動し得る制御器とを具えることを特徴とする薬剤送給装置。 - 前記アクチュエータは前記第1の複数個のマイクロニードルの少なくとも1個を全方向に突出させるように作動可能である請求項31の装置。
- 前記第1の複数個のマイクロニードルのおのおのが約25〜200ミクロンの範囲の内径を有している請求項31の装置。
- 前記第1の複数個のマイクロニードルのおのおのが、金属、プラスチック、ガラス、及び結晶体のうちの少なくとも一つから製造されている請求項31の装置。
- 前記第1の複数個のマイクロニードルのおのおのが、最大約2.5 mmまで、皮膚の表面内に貫入するよう作動し得る末端を有する請求項31の装置。
- 前記第1の複数個のマイクロニードルのおのおのが導管を通じて、薬剤送給マイクロチャネルに少なくとも間欠的に流体連通している請求項31の装置。
- 少なくとも1個の薬剤送給マイクロチャネルの送給は少なくとも一部、液圧力に依存している請求項31の装置。
- 前記複数個の薬剤送給マイクロチャネルが一群のものとして製作されている請求項31の装置。
- 前記薬剤送給マイクロチャネルはほぼ5cmの最大直径内に形成されたほぼ50〜150個のマイクロチャネルを有する一群のものとして製作されている請求項31の装置。
- 前記第1の複数個のマイクロニードルのおのおのは50〜500ナノリットルの範囲内の流体の容積のために寸法が定められたものである請求項31の装置。
- 前記薬剤送給マイクロチャネルが空になった時を決定するように作動し得る検出器を具える請求項31の装置。
- 第3の複数個のマイクロニードルと、複数個の監視マイクロチャネルとを具え、各監視マイクロチャネルが試薬に関連している請求項31の装置。
- 少なくとも1個の薬剤送給マイクロチャネルをポリマでシールした請求項31の装置。
- 前記制御器はタイムスケジュールに基づいて、薬剤の送給を開始するように作動可能である請求項31の装置。
- 前記制御器は薬剤送給タイムスケジュールを調整するように作動可能である請求項44の装置。
- 前記制御器は可搬式コンピュータ装置を結合するように作動可能である請求項31の装置。
- 前記可搬式コンピュータ装置がPDAである請求項46の装置。
- 前記制御器、及び前記可搬式コンピュータ装置の少なくとも一方が検体試験の時間を選択し、又は変更するように作動可能である請求項46の装置。
- 前記複数個のマイクロニードル、及び複数個の薬剤送給マイクロチャネルが使い捨てである請求項31の装置。
- 前記制御器、及び前記アクチュエータが再使用可能である請求項31の装置。
- 前記複数個のマイクロニードル、複数個の薬剤送給マイクロチャネル、アクチュエータ、及び制御器が可搬式である請求項31の装置。
- マイクロニードルを突出させる前に、少なくとも1個の注射位置を加熱するように作動し得る加熱源を具える請求項31の装置。
- 前記加熱源が光学加熱源である請求項52の装置。
- ハウジングを表面に取り付けるように作用し得る接着剤を少なくとも一部、コーティングしたハウジングを具え、前記複数個のマイクロニードル、及び前記薬剤送給マイクロチャネルを前記ハウジングが少なくとも一部、包囲している請求項31の装置。
- 前記複数個のマイクロニードル、及び前記薬剤送給マイクロチャネルを少なくとも一部包囲するほぼディスク状のハウジングを具える請求項31の装置。
- 対象物から流体試料を引き出すように作動し得る検体監視部と、対象物に薬剤を送給するように作動し得る薬剤送給部とを有する装置において、前記装置は
第1の複数個のマイクロニードルと、
複数個の監視マイクロチャネルであって、前記第1の複数個のマイクロニードルのおのおのが対応する監視マイクロチャネルに少なくとも間欠的に流体連通しており、各前記監視マイクロチャネルが試薬に関連している複数個の監視マイクロチャネルと、
第2の複数個のマイクロニードルと、
複数個の薬剤送給マイクロチャネルであって、前記第2の複数個のマイクロニードルのおのおのが対応する薬剤送給マイクロチャネルに少なくとも間欠的に流体連通しており、各薬剤送給マイクロチャネルが少なくとも一部、薬剤を充填されている複数個の薬剤送給マイクロチャネルと、
前記対象物から前記流体試料を引き出すこと、及び前記対象物に薬剤を送給することのうちの一方を行うため、各マイクロニードルを突出させるように作動し得る少なくとも1個のアクチュエータと、
前記流体試料の検体試験、及び薬剤の送給を開始するように作動し得る制御器とを具えることを特徴とする装置。 - 第3の複数個のマイクロニードルと、キャリブレーション流体を充填した複数個のキャリブレーションマイクロチャネルとを具え、キャリブレーションの目的で少なくとも1個の検査を開始する請求項56の装置。
- a)第1の複数個のマイクロニードルを設ける工程と、
b)複数個の監視マイクロチャネルを設け、第1の複数個のマイクロニードルのおのおのが監視マイクロチャネルに少なくとも間欠的に流体連通し、各監視マイクロチャネルを試薬に関連させる工程と、
c)対象物から流体試料を得るため、マイクロニードルを連続して突出させる工程と、
d)前記流体試料の検体試験を開始する工程と、
e)前記c)の工程と、d)の工程とを自動的に繰り返すように作動し得る制御器を設ける工程とを具えることを特徴とする自動検体監視方法。 - a)第1の複数個のマイクロニードルを設ける工程と、
b)複数個の薬剤送給マイクロチャネルを設け、第1の複数個のマイクロニードルのおのおのを対応する薬剤送給マイクロチャネルに少なくとも間欠的に流体連通させ、各薬剤送給マイクロチャネルに少なくとも一部、薬剤を充填する工程と、
c)対象物に前記薬剤を送給するため、マイクロニードルを連続して突出させる工程と、
d)前記工程c)を自動的に繰り返すように作動し得る制御器を設ける工程とを具えることを特徴とする自動薬剤送給方法。
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Also Published As
Publication number | Publication date |
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EP2471570A2 (en) | 2012-07-04 |
US20030153900A1 (en) | 2003-08-14 |
EP2471571A2 (en) | 2012-07-04 |
EP1480710A4 (en) | 2008-06-25 |
EP1480710B1 (en) | 2017-05-17 |
EP2471570A3 (en) | 2012-09-26 |
US7004928B2 (en) | 2006-02-28 |
CA2476308A1 (en) | 2003-08-14 |
JP4856849B2 (ja) | 2012-01-18 |
WO2003066128A2 (en) | 2003-08-14 |
WO2003066128A3 (en) | 2003-12-11 |
US20060094985A1 (en) | 2006-05-04 |
AU2003215064A1 (en) | 2003-09-02 |
US9603562B2 (en) | 2017-03-28 |
EP2471570B1 (en) | 2018-11-07 |
DK1480710T3 (en) | 2017-07-03 |
US10772550B2 (en) | 2020-09-15 |
JP2010279704A (ja) | 2010-12-16 |
US20170319121A1 (en) | 2017-11-09 |
US8303518B2 (en) | 2012-11-06 |
AU2003215064A8 (en) | 2003-09-02 |
CA2476308C (en) | 2011-04-26 |
EP2471571A3 (en) | 2012-09-26 |
EP1480710A2 (en) | 2004-12-01 |
US20130158430A1 (en) | 2013-06-20 |
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