US20020010406A1 - Methods and apparatus for expressing body fluid from an incision - Google Patents

Methods and apparatus for expressing body fluid from an incision Download PDF

Info

Publication number
US20020010406A1
US20020010406A1 US09960806 US96080601A US2002010406A1 US 20020010406 A1 US20020010406 A1 US 20020010406A1 US 09960806 US09960806 US 09960806 US 96080601 A US96080601 A US 96080601A US 2002010406 A1 US2002010406 A1 US 2002010406A1
Authority
US
Grant status
Application
Patent type
Prior art keywords
incision
skin
housing
stimulator
member
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US09960806
Inventor
Joel Douglas
Jeffrey Roe
Henry Grage
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diabetes Care Inc
Original Assignee
Roche Diagnostics Operations Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/151Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15186Devices loaded with a single lancet, i.e. a single lancet with or without a casing is loaded into a reusable drive device and then discarded after use; drive devices reloadable for multiple use
    • A61B5/15188Constructional features of reusable driving devices
    • A61B5/15192Constructional features of reusable driving devices comprising driving means, e.g. a spring, for retracting the lancet unit into the driving device housing
    • A61B5/15194Constructional features of reusable driving devices comprising driving means, e.g. a spring, for retracting the lancet unit into the driving device housing fully automatically retracted, i.e. the retraction does not require a deliberate action by the user, e.g. by terminating the contact with the patient's skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045Devices for taking samples of body liquids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150015Source of blood
    • A61B5/150022Source of blood for capillary blood or interstitial fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150053Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150061Means for enhancing collection
    • A61B5/150068Means for enhancing collection by tissue compression, e.g. with specially designed surface of device contacting the skin area to be pierced
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150053Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150061Means for enhancing collection
    • A61B5/150076Means for enhancing collection by heating
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150053Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150061Means for enhancing collection
    • A61B5/150083Means for enhancing collection by vibration, e.g. ultrasound
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150374Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381Design of piercing elements
    • A61B5/150412Pointed piercing elements, e.g. needles, lancets for piercing the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/150007Details
    • A61B5/150374Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381Design of piercing elements
    • A61B5/150503Single-ended needles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/151Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101Details
    • A61B5/15103Piercing procedure
    • A61B5/15107Piercing being assisted by a triggering mechanism
    • A61B5/15111Semi-automatically triggered, e.g. at the end of the cocking procedure, for instance by biasing the main drive spring or when reaching sufficient contact pressure, the piercing device is automatically triggered without any deliberate action by the user
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/151Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101Details
    • A61B5/15103Piercing procedure
    • A61B5/15107Piercing being assisted by a triggering mechanism
    • A61B5/15113Manually triggered, i.e. the triggering requires a deliberate action by the user such as pressing a drive button
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/151Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101Details
    • A61B5/15115Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids
    • A61B5/15117Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids comprising biased elements, resilient elements or a spring, e.g. a helical spring, leaf spring, or elastic strap
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/15Devices for taking samples of blood
    • A61B5/151Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15186Devices loaded with a single lancet, i.e. a single lancet with or without a casing is loaded into a reusable drive device and then discarded after use; drive devices reloadable for multiple use
    • A61B5/15188Constructional features of reusable driving devices
    • A61B5/1519Constructional features of reusable driving devices comprising driving means, e.g. a spring, for propelling the piercing unit
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045Devices for taking samples of body liquids
    • A61B2010/008Interstitial fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743Type of operation; Specification of treatment sites
    • A61B2017/00747Dermatology
    • A61B2017/00765Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0295Strip shaped analyte sensors for apparatus classified in A61B5/145 or A61B5/157

Abstract

A sample of a body fluid such as blood or interstitial fluid is obtained from a body by lancing a portion of a user's skin, preferably in an area other than a finger tip, to form an incision. After the needle has been removed from the incision, a force is applied to depress the skin in a manner forming a ring of depressed body tissue in surrounding relationship to the incision, causing the incision to bulge and the sides of the incision to open, whereby body fluid is forced out through the opening of the incision. A stimulator member is mounted to an end of a lancet-carrying housing for applying the force. The stimulator member can be movable relative to the housing, and can be either heated or vibrated to promote movement of the body fluid.

Description

    PRIOR APPLICATIONS
  • This application claims benefit of copending application Ser. Nos. 08/017,133 filed May 17, 1996; 08/019,918 filed Jun. 14, 1996; 08/023,658 filed Aug. 1, 1996; 08/025,340 filed Sep. 3, 1996; 08/714,548 filed Sep. 16, 1996; and 08/710,456 Sep. 17, 1996; the disclosures of which are incorporated herein by reference. [0001]
  • The present invention is related to inventions disclosed in the following concurrently filed, commonly assigned U.S. applications: Ser. No. , entitled “Body Fluid sampling Device and Methods of Use” (attorney docket No. 018176-039); Ser. No. , entitled “Methods and Apparatus for Sampling Body Fluid” (attorney docket 018176-057); Ser. No. , entitled “Disposable Element for Use in a Body Fluid Sampling Device” ((attorney docket 018176-058); and Ser. No. , entitled “Methods and Apparatus for Sampling and Analyzing Body Fluid” (attorney docket 018176-059). The disclosures of those applications are incorporated herein by reference.[0002]
  • FIELD OF THE INVENTION
  • The present invention relates to lancing devices and methods for obtaining samples of blood and other fluids from the body for analysis or processing. [0003]
  • BACKGROUND OF THE INVENTION
  • Many medical procedures in use today require a relatively small sample of blood, in the range of 5-50 μL. It is more cost effective and less traumatic to the patient to obtain such a sample by lancing or piercing the skin at a selected location, such as the finger, to enable the collection of 1 or 2 drops of blood, than by using a phlebotomist to draw a tube of venous blood. With the advent of home use tests such as self monitoring of blood glucose, there is a requirement for a simple procedure which can be performed in any setting by a person needing to test. [0004]
  • Lancets in conventional use generally have a rigid body and a sterile needle which protrudes from one end. The lancet may be used to pierce the skin, thereby enabling the collection of a blood sample from the opening created. The blood is transferred to a test device or collection device. Blood is most commonly taken from the fingertips, where the supply is generally excellent. However, the nerve density in this region causes significant pain in many patients. Sampling of alternate site, such as earlobes and limbs, is sometimes practiced to access sites which are less sensitive. These sites are also less likely to provide excellent blood samples and make blood transfer directly to test devices difficult. [0005]
  • Repeated lancing in limited surface areas (such as fingertips) results in callous formation. This leads to increased difficulty in drawing blood and increased pain. [0006]
  • To reduce the anxiety of piercing the skin and the associated pain, many spring loaded devices have been developed. The following two patents are representative of the devices which were developed in the 1980's for use with home diagnostic test products. [0007]
  • Cornell et al. U.S. Pat. No. 4,503,856 describes a spring loaded lancet injector. The reusable device interfaces with a disposable lancet. The lancet holder may be latched in a retracted position. When the user contacts a release, a spring causes the lancet to pierce the skin at high speed and then retract. The speed is important to reduce the pain associated with the puncture. [0008]
  • Levin et al. U.S. Pat. No. 4,517,978 describes a blood sampling instrument. This device, which is also spring loaded, uses a standard disposable lancet. The design enables easy and accurate positioning against a fingertip so the impact site can be readily determined. After the lancet pierces the skin, a bounce back spring retracts the lancet to a safe position within the device. [0009]
  • In institutional settings, it is often desirable to collect the sample from the patient and then introduce the sample to a test device in a controlled fashion. Some blood glucose monitoring systems, for example, require that the blood sample be applied to a test device which is in contact with a test instrument. In such situations, bringing the finger of a patient directly to the test device poses some risk of contamination from blood of a previous patient. With such systems, particularly in hospital settings, it is common to lance a patient, collect a sample in a micropipette via capillary action and then deliver the sample from the pipette to the test device. [0010]
  • Haynes U.S. Pat. No. 4,920,977 describes a blood collection assembly with lancet and microcollection tube. This device incorporates a lancet and collection container in a single device. The lancing and collection are two separate activities, but the device is a convenient single disposable unit for situations when sample collection prior to use is desirable. Similar devices are disclosed in Sarrine U.S. Pat. No. 4,360,016, and O'Brien U.S. Pat. No. 4,924,879. [0011]
  • Jordan et al. U.S. Pat. No. 4,850,973 and No. 4,858,607, disclose a combination device which may be alternatively used as a syringe-type injection device and a lancing device with disposable solid needle lancet, depending on configuration. [0012]
  • Lange et al. U.S. Pat. No. 5,318,584 describes a blood lancet device for withdrawing blood for diagnostic purposes. This invention uses a rotary/sliding transmission system to reduce the pain of lancing. The puncture depth is easily and precisely adjustable by the user. [0013]
  • Suzuki et al. U.S. Pat. No. 5,368,047, Dombrowski U.S. Pat. No. 4,654,513 and Ishibashi et al. U.S. Pat. No. 5,320,607 each describe suction-type blood samplers. These devices develop suction between the lancing site and the end of the device when the lancet holding mechanism withdraws after piercing the skin. A flexible gasket around the end of the device helps seal the end around the puncture site until adequate sample is drawn from the puncture site or the user pulls back on the device. [0014]
  • Garcia et al. U.S. Pat. No. 4,637,403 and Haber et al. U.S. Pat. No. 5,217,480, disclose combination lancing and blood collection devices which use a diaphragm to create a vacuum over the wound site. [0015]
  • Erickson et al. U.S. Pat. No. 5,582,184, describes a means of collecting and measuring body fluids. This system uses a coaxial hollow lancet and capillary tube disposed within a spacer member. The spacer member limits the depth of lancet penetration, and compresses body tissue around the lancet while the lancet is in the skin, for improving the flow of interstitial fluid to the incision. However, the incision may tend to close around the lancet, thereby limiting the amount of body fluid that can be obtained. [0016]
  • Single use devices have also been developed for single use tests, i.e. home cholesterol testing, and for institutional use to eliminate cross-patient contamination multi-patient use. Crossman et al. U.S. Pat. No. 4,869,249, and Swierczek U.S. Pat. No. 5,402,798, also disclose disposable, single use lancing devices. [0017]
  • U.S. Pat. Nos. 5,421,816; 5,445,611 and 5,458,140 disclose, as a replacement for invasive sampling, the use of ultrasound to act as a pump for expressing interstitial fluid directly through intact (i.e., non-lanced) skin. The amount of fluid which can be obtained by way of such non-invasive vibration is minimal, however. [0018]
  • The disclosures of the above patents are incorporated herein by reference. [0019]
  • Even with the many improvements which have been made, the pain associated with lancing remains a significant issue for many patients. The need for blood sampling and the fear of the associated pain is also a major obstacle for the millions of diagnosed diabetics, who do not adequately monitor their blood glucose due to the pain involved. Moreover, lancing to obtain a blood sample for other diagnostic applications is becoming more commonplace, and a less painful, minimally invasive device is needed to enhance those applications and make those technologies more acceptable. [0020]
  • An object of the present invention therefore, is to provide a device and a method for obtaining a sample of bodily fluid through the skin which is virtually pain free and minimally invasive, particularly by penetrating less sensitive areas of the skin. [0021]
  • Furthermore, known lancing devices include manually actuable buttons for triggering the lance-driving mechanism once the user has placed the device against his/her skin. Because the user knows the precise instant when the lancet will be triggered and pain will be felt, there is a tendency for the user to jerk or raise the device at the instant of triggering, which can lead to inconsistent skin penetration, or possibly no penetration. Therefore, a further object of the invention is to provide a lancing device which eliminates such a tendency on the part of the user. [0022]
  • Therefore, it is another object of the invention to provide a lancet carrier which eliminates the above-mentioned shortcomings. [0023]
  • Another object of this invention is to provide a method which can result in a sample of either blood or interstitial fluid, depending on the sample site and the penetration depth utilized. While there are no commercially available devices utilizing interstitial fluid (ISF) at this time, there are active efforts to establish the correlation of analytes, such as glucose, in ISF compared to whole blood. If ISF could be readily obtained and correlation is established, ISF may be preferable as a sample since there is no interference of red blood cells or hematocrit adjustment required. [0024]
  • Another object of this invention is to provide a method which can draw a small but adjustable sample, i.e. 3 μL for one test device and 8 μL for another test device, as appropriate. [0025]
  • Another object of this invention is to provide a method by which the drawn sample is collected and may be easily presented to a testing device, regardless of the location of the sample site on the body. This approach helps with infection control in that multiple patients are not brought in contact with a single test instrument; only the sampling device with a disposable patient-contact portion is brought to the test instrument. Alternatively, the disposable portion of a test device may be physically coupled with the sampler so the sample can be brought directly into the test device during sampling. The test device may then be read in a test instrument if appropriate or the testing system can be integrated into the sampler and the test device can provide direct results displayed for the patient. [0026]
  • It is a further object of the invention is to provide a device for minimally invasive sampling comprising a reusable sampler and disposable sample lancet and collection device. [0027]
  • SUMMARY OF THE INVENTION
  • The present invention involves a method of obtaining a sample of fluid from a body. The method comprises applying a skin-lancing medium against a skin surface to form an incision therein, removing the skin-lancing medium from the incision; and thereafter applying a force to depress the skin in a manner forming a ring of depressed body tissue in surrounding relationship to the incision, causing the incision to bulge and the sides of the incision to open, whereby body fluid is forced out through the opening of the incision. [0028]
  • The invention also relates to a device for sampling body fluid which comprises a housing having an open end, and a skin lancing mechanism for applying a skin-lancing medium against a skin surface to form an incision therein and then remove the skin-lancing medium from the incision. A stimulator member is mounted to the housing at the open end thereof for movement relative to the housing. The stimulator member extends about a longitudinal axis of the housing and is adapted to engage the skin surface to bulge and open the incision in response to a pressing of the end face against the skin surface. [0029]
  • The invention also relates to a device for expressing body fluid from a lanced skin surface, which comprises a housing, and a stimulator mechanism mounted to the housing at an end thereof. The stimulator mechanism includes a generally circular array of stimulator elements each mounted to the housing for movement toward and away from a longitudinal axis of the housing. An actuator is mounted to the housing for displacing the stimulator elements toward the axis. [0030]
  • The invention also relates to a device for expressing body fluid from a lanced skin surface, which comprises a housing and a stimulator member mounted on the housing at an end thereof. The stimulator member comprises a coil spring which is compressible toward the housing in response to being pushed against a user's skin in surrounding relationship to a lanced portion thereof. [0031]
  • Another aspect of the invention relates to a device for expressing body fluid from a lanced skin surface which comprises a housing and a hollow stimulator member mounted at an end of the housing and adapted to engage a user's skin surface in surrounding relationship to a lanced portion thereof. In order to promote the flow of body fluid, the stimulator member can be heated, or vibrated. If vibrated, the stimulator member applies an ultrasonic frequency to the skin surface. [0032]
  • The invention also relates to a device for expressing body fluid from a lanced skin surface which comprises a housing and a hollow stimulator member mounted at an end of the housing for longitudinal movement relative to the housing and adapted to contact a user's skin surface in surrounding relationship to a lanced portion thereof. A motor is mounted in the housing and a reciprocatory mechanism is connected to the motor to be driven thereby, and is operably connected to the stimulator member for reciprocating the stimulator member along a longitudinal axis of the stimulator member. [0033]
  • BRIEF DESCRIPTION OF THE DRAWING
  • The objects and advantages of the invention will become apparent from the following detailed description of preferred embodiments thereof in connection with the accompanying drawing in which like numerals designate like elements and in which: [0034]
  • FIG. 1 is a longitudinal sectional view through a blood sampling device according to a first embodiment of the invention, with the lancet carrier in an unarmed condition; [0035]
  • FIG. 2 is a view similar to FIG. 1, with the lancet carrier in an armed condition; [0036]
  • FIG. 3 is a view similar to FIG. 2 after the lancet carrier has been triggered and a lancet is penetrating the skin; [0037]
  • FIG. 4 is a fragmentary view similar to FIG. 1 after an incision has been formed; [0038]
  • FIG. 5 is a view similar to FIG. 4 showing a stimulator member of the device being depressed to cause the incision to bulge and open; [0039]
  • FIG. 6 is a view similar to FIG. 5 after a stimulating action has been performed to form a drop of blood at the open end of the incision; [0040]
  • FIG. 7 is a fragmentary longitudinal sectional view through a second embodiment of the invention; [0041]
  • FIG. 8 is a fragmentary longitudinal sectional view taken through a third embodiment of the invention; [0042]
  • FIG. 9 is a side elevational view of a fourth embodiment of the invention pressed against a skin surface; [0043]
  • FIG. 10 is an end view of the device depicted in FIG. 9; [0044]
  • FIG. 11 is a view similar to FIG. 9 after the device has been compressed against the skin surface to bulge and open an incision; [0045]
  • FIG. 12 is an end view of the device in the condition depicted in FIG. 11; [0046]
  • FIG. 13 is a fragmentary longitudinal sectional view taken through a fifth embodiment of the invention while in a first state of operation; [0047]
  • FIG. 14 is a view similar to FIG. 13 with the device in a second condition of operation; [0048]
  • FIG. 15 is a fragmentary longitudinal sectional view taken through a sixth embodiment of the invention in a first condition of operation thereof; [0049]
  • FIG. 16 is a view similar to FIG. 15 with the device in another condition of operation; [0050]
  • FIG. 17 is a view similar to FIG. 16 of yet a further condition of operation of the device; [0051]
  • FIG. 18 is a side elevational view, partly in longitudinal section of yet another embodiment of the invention; and [0052]
  • FIG. 19 is a longitudinal sectional view taken through still a further embodiment of the invention.[0053]
  • DETAILED DESCRIPTION OF A PREFERRED EMBODIMENT OF THE INVENTION
  • A lancing device [0054] 10 (see FIG. 1) according to one preferred embodiment of the invention comprises an outer housing 12 having upper and lower portions 14, 16 connected together, and an inner housing 18 fixed to the outer housing.
  • Mounted for vertical reciprocation in the upper portion [0055] 14 of the outer housing 12 is a cocking mechanism 20 comprising a pull handle 22 to which is fixedly secured a hollow draw tube 24. Fixed to an inner wall of the draw tube 24 is a draw ring 26.
  • Situated within the draw tube [0056] 24 is a draw bar 30 having a pair of flexible hooks 32 at its upper end. The hooks are releasably latched to a sleeve 34 which is movably disposed within the draw ring 26. A coil compression spring 36 acts between a flange 33 of the sleeve 34 and an inner flange 38 of the draw ring 26.
  • A trigger sleeve [0057] 35 is mounted within the lower portion 16 of the outer housing 12. A lower end of the trigger sleeve rests upon a first outer flange 37A of the inner housing, and a second outer flange 37B of the inner housing rests upon an inner projection 39 of the trigger sleeve.
  • At its lower end the draw bar [0058] 30 frictionally holds a skin-lancing medium in the form of a disposable lancet 40 in which a needle 42 is disposed. The draw bar 30 includes a flexible latch finger 44 that has a projection 45 adapted to be received in a hole 46 of the inner housing 18 (see FIG. 2) when the device is armed. A trigger member 49 is mounted in a hole 47 of the trigger sleeve 35 and includes an arm 48 extending partially into the hole 46. The trigger 46 includes an inclined cam follower surface 50.
  • A coil compression spring [0059] 52 acts between a top wall 54 of the inner housing 18 and a shoulder 56 of the draw bar.
  • Slidably disposed within a lower end of the lower portion of the outer housing is a firing tube [0060] 60 which includes an upper cam surface 62. Fixed to a lower end of the firing tube 60 is an outer hollow stimulator member in the form of a cylindrical ring 64, having an end surface 65 of generally frusto-conical shape so as to be oriented at a downward and inward inclination to generally face a longitudinal axis A of the device.
  • Disposed coaxially within the firing tube [0061] 60 and outer stimulator ring 64 is an inner hollow stimulator member also in the form of a cylindrical ring 66 having a frusto-conical end surface 67 also oriented at a downward and inward inclination.
  • The end surfaces [0062] 65 and 67 are of circular configuration when viewed along the axis A, other configurations, such as polygonal, oval, etc., are possible.
  • A coil compression spring [0063] 68 acts between an upper end of the outer stimulator ring 64 and a downwardly facing shoulder 70 of the inner stimulator ring 66.
  • The inner stimulator ring [0064] 66 includes a lance stop flange 72 adapted to be engaged by a lance ring 74 of the lancet 40 as will be explained.
  • The first flange [0065] 37A of the inner housing rests upon a support sleeve 80 which, in turn, rests upon an upper end of the inner stimulator ring 66.
  • In practice, when a fluid sample, such as blood or interstitial fluid, is to be taken from a user's body, a lancing device according to the present invention can be used to minimize pain. To do so, a region of the user's body having less sensitivity than, for example, a fingertip, is selected. Such a low-sensitivity region could be the user's forearm for example. Initially, the handle [0066] 22 is pulled up to raise the drawbar 30 until the projection 45 of the latch finger 44 snaps into the hole 44 of the inner housing 18, as shown in FIG. 2. Simultaneously, the spring 52 is compressed.
  • If the outer stimulator ring [0067] 64 is pressed against the user's skin S, e.g., on the selected forearm region FA, the ring 64 and its cam surface 62 are moved upwardly to displace the trigger radially inwardly, whereupon the projection 45 of the latch finger 44 is disengaged from the hole 46. Accordingly, the spring 52 expands to displace the drawbar 30 downwardly so that the needle 42 punctures the skin sufficiently deep to cut capillaries in the superficial vascular plexus, as shown in FIG. 3. Simultaneously, the spring 68 is compressed. The extent of displacement of the drawbar 30 is limited by engagement between the lance ring 74 with the lance stop 72.
  • Once lancing has occurred, the compressed spring [0068] 68 expands to raise the drawbar, as well as the needle 42 and inner stimulator ring 66 from the skin (see FIG. 4).
  • The user then alternately applies and releases a downward force on the outer housing [0069] 12. Each time that a downward force is applied, the end face 65 of the outer stimulator ring 64 exerts a downward force F which depresses a ring-shaped portion of the skin and body tissue which is disposed in surrounding relationship to the wound or incision I, causing the wounded area to bulge while pulling apart the sides of the wound (see FIG. 5). Hence, fluid such as blood or interstitial fluid is trapped and pressurized so that it travels upwardly through the pulled-open end of the wound since the surrounding ring of depressed skin and body tissue restricts the outward flow of fluid. That action is enhanced by the fact that the force F is inclined inwardly toward the axis A to force the fluid toward the bulged area.
  • When the downward force is released, the sides of the wound close, and fresh fluid flows toward the area of the wound to replace fluid which had been forced upwardly through the wound. As the downward force is reapplied, the above-described action is repeated and additional fluid is forced through the wound. Eventually, this “pumping” action results in the formation of a suitably large drop D of fluid (FIG. 6). [0070]
  • It will thus be appreciated that the present invention enables an ample supply of blood, interstitial fluid or other body fluid to be obtained relatively painlessly from areas of the body which typically possess lesser amounts of such fluid as compared with the highly sensitive fingertip region. [0071]
  • Note that each time that the downward force is applied to the outer housing, the outer stimulator ring [0072] 64 moves upwardly relative to the inner stimulator ring 66 so that the end surface 67 of the inner ring 66 also contacts the skin surface S at a location inwardly of the outer face 65, thereby promoting the displacement of fluid inwardly toward the wound. However, the present invention can be practiced by a single stimulator ring arrangement 64A as shown in FIG. 8.
  • While the surfaces [0073] 65, 67 are continuous, i.e., non-interrupted, it may be desirable to provide either or both of those surfaces with circumferentially spaced recesses 80 as shown in FIG. 7. The surface(s) 65A, 67A will still depress a ring of body tissue surrounding the wound, but the areas of the ring corresponding to the location of the recesses will be depressed to a lesser extent than the other areas. Those lesser depressed areas will provide less resistance to fluid flow and will thus enable some fluid to leak past the ring, which would be beneficial in the event that the user neglects to release the downward pressure on the device.
  • The stimulator member need not be in the form of a ring. As depicted in FIGS. [0074] 9-12, the stimulator member can be in the form of a helical spring 90 formed by a flat strip 92. Such a spring would function in somewhat similar fashion to the double-ring arrangement of FIGS. 1-7 in that a stimulator surface gradually comes into contact with the skin in a radially inward direction to aid in propelling blood or interstitial fluid toward the center axis. In that regard, FIGS. 9 and 10 depict a condition when the spring 90 is uncompressed. In contrast, FIGS. 11 and 12 depict a condition wherein the spring is fully compressed. Shaded regions in FIGS. 10 and 12 represent contact between the spring and the skin. It will be appreciated that during compression of the spring, the contact region of the spring progresses gradually radially inwardly, causing blood or interstitial fluid to be pushed toward the axis A and thus toward the bulged area of the skin.
  • Depicted in FIGS. 13 and 14 is yet another alternative embodiment wherein the outer stimulator ring [0075] 64B is interconnected to the inner stimulator ring 66B by levers 100 which are pivoted to the firing tube 60B. Thus, upward sliding movement of the outer ring 64B is transmitted as a downward force to the inner ring 66B to slide the latter downwardly and intensify the pumping action.
  • A further embodiment is depicted in FIGS. [0076] 15-17 wherein the firing tube 60C has a carrier tube 102 affixed at a lower end thereof. Pivotably mounted on the carrier tube 102 is a circular array of levers 104 each having an upper and lower end, each lower end carrying a stimulator element in the form of a roller 106. Each lever 104 is rotatable about an axis extending orthogonally relative to the axis of the housing.
  • An inner ring [0077] 110 is slidable up and down, either by manual force, or by a motor-driven cam (e.g., of the type disclosed later in connection with FIG. 19). That ring 110 has a beveled cam face 112 formed on its lower end. When the device is pressed against the skin, following a lancing procedure, the ring 110 is moved downwardly so that the cam face 112 engages rollers 108 mounted on upper ends of the levers. Hence, the levers 104 are rotated such that the lower rollers 106 are displaced inwardly and upwardly at a location disposed below the open end of the bulged wound to open the wound and force blood or interstitial fluid toward the wound to form a drop D. When the levers are not contacted by the cam face 112, the rollers 106 gravitate to a rest position shown in FIG. 15. Repeated applications of the downward force cause the drop to become gradually enlarged as explained earlier.
  • Depicted in FIG. 18 is an alternative embodiment similar to that depicted in FIGS. [0078] 1-6, except that the lower end surface of the outer stimulator ring 64D is provided with a hollow stimulator element 114 which is electrically connected to a battery 116 mounted in an upper end of the device. The element can be either an electrical resistance element (i.e., a heater) or a vibrator such as a piezoelectric transducer, intended to stimulate fluid flow. A heater will expand the capillaries and make the blood or interstitial fluid less viscous and thus more flowable, in order to increase the amount of the body fluid sample.
  • On the other hand, if the element [0079] 114 is a vibrator, such as a piezoelectric transducer, vibrations can be created which stimulate the flow of body fluid. This could be achieved by operating the transducer to produce frequencies below 28,000 cycles per second. Alternatively, ultrasonic frequencies, i.e., frequencies above 20,000 cycles per second, will create interferometric wave patterns inside the skin that cause contractions forcing fluid upwardly from the wound. The frusto-conical shape 114A of the end face of the element will optimize the creation of such wave patterns. It may be further beneficial to employ a heater, such as an infrared emitter, mounted in the housing which vasodilates the capillaries to increase blood flow. Another advantage of the use of such frequencies is that only minimal downward force to the device may be necessary since the wave patterns may produce an ample pumping action.
  • FIG. 19 depicts a device which is not automatically fired, but rather requires manual actuation of lever [0080] 130 against a bias of a spring 132 to force a trigger 134 to push a projection 136 out of a hole 138 (when the projection extends into that hole).
  • Mounted in a housing [0081] 140 of the device are a battery 142 and electric motor 144 connected to the battery to be actuated thereby. The motor 144 rotates a sleeve 146 about the axis A. The sleeve includes a cam surface 148 which engages a follower roller 150 mounted on a tube 152.
  • As the sleeve [0082] 146 rotates, the cam surface pushes the tube 152 downwardly against the bias of a coil compression spring 154, to push an inner stimulator ring 156 repeatedly against a skin surface, thereby pumping blood to the top of an incision in the same manner described earlier herein. The inner stimulator ring 156 reciprocates along the axis A within an outer stimulator ring 155. This embodiment eliminates the need for the user to pulsate the device up and down; the pumping operation is achieved automatically in response to actuation of the lever 130.
  • The cam mechanism [0083] 146 can be used in an automatically firing device, such as that disclosed in connection with FIG. 1.
  • It will be appreciated that the present invention enables a sampling of blood or interstitial fluid to be taken from areas of the body, such as a forearm, that are less insensitive to pain, despite the fact that those areas typically have relatively less fluid as compared, for example, to fingertips (which are highly sensitive to pain). [0084]
  • Therefore, there will be less reluctance on the part of users to have a sampling procedure performed. For example, diabetics who experience a relatively high fear of pain will be less likely to neglect monitoring their blood glucose levels. [0085]
  • Another suitable skin lancing device that can be used to practice the present invention is that disclosed in concurrently filed application Ser. No. (Attorney Docket 018176-039), the disclosure of which is incorporated herein by reference. [0086]
  • In lieu of using a lancet as a skin-lancing medium, other skin-lancing media can be used, such as a laser, or known pneumatic or hydraulic injectors of the type which inject pressurized gas or liquid against the skin. Such auto injectors are sold by Becton-Dickinson, for example, to inject insulin. By eliminating the insulin and merely injecting the gas (e.g., air or nitrogen) or liquid (e.g., water) at pressures above 30 psi. an incision could be formed in the skin for taking samples of body fluid. Advantageously, small particles could be mixed with the gas to promote the tissue-cutting action. The particles could comprise carbon particles of from 1 micron to 0.010 inches in diameter. [0087]
  • Although the present invention has been described in connection with preferred embodiments thereof, it will be appreciated by those skilled in the art that additions, deletions, modifications, and substitutions not specifically described may be made without departing from the spirit and scope of the invention as defined in the appended claims. [0088]

Claims (20)

    What is claimed:
  1. 1. A method of obtaining a sample of body fluid from a body, comprising the steps of:
    A) applying a skin-lancing deice against the skin of a user to form an incision in the skin;
    B) removing the skin-lancing device from the incision; and thereafter
    C) applying a force to depress the skin in a manner forming a ring of depressed body tissue in surrounding relationship to the incision wherein a stimulating member and a plurality of levers act to bulge and stretch the incision open, whereby body fluid is expressed from the opening of the incision.
  2. 2. The method according to claim 1, wherein forces between the stimulating member and the skin causes the stimulating member to retain the skin in an stretched position.
  3. 3. The method according to claim 1 wherein step C includes applying the force in a direction inclined generally toward the bulged incision.
  4. 4. The method according to claim 1 wherein step C comprises applying the force progressively closer to the incision.
  5. 5. The method according to claim 1 wherein step C includes applying heat in the region of the incision.
  6. 6. The method according to claim 1 wherein step C includes applying ultrasonic frequency to the region of the incision.
  7. 7. The method according to claim 1 wherein step A comprises lancing a region of the user's body other than a finger tip.
  8. 8. The method according to claim 1 wherein step A comprises applying a lancet against the skin.
  9. 9. A device for sampling body fluid comprising:
    a housing having an open end;
    a skin-lancing mechanism mounted in the housing for applying a skin-lancing medium against a skin surface to form an incision therein, and then remove the skin-lancing medium from the incision;
    a plurality of levers mounted to the housing at the open end thereof for movement relative to the housing, the plurality of levers pivotally attached thereto, wherein the levers cause the skin surface to form a bulge in response to a pressing on the housing; and
    a stimulator member mounted to the housing at the open end thereof for movement relative to the housing, the stimulator member extending about a longitudinal axis of the housing the axis and adapted to engage the skin surface of the bulge and to stretch open the incision in response to a pressing of the end face against the skin surface.
  10. 10. The device according to claim 9 wherein the end face is inclined to generally face the axis.
  11. 11. The device according to claim 9 wherein the stimulator member extends continuously about the axis.
  12. 12. The device according to claim 9 wherein the stimulator member includes circumferentially spaced interruptions.
  13. 13. The device according to claim 9 wherein the stimulator member is movable relative to the housing along the axis.
  14. 14. The device according to claim 9 wherein the stimulator member comprises a first stimulator member, and further including at least one additional stimulator member arranged in telescoping relationship to the first stimulator member, the stimulator members being relatively movable along the axis.
  15. 15. The device according to claim 14 wherein the stimulator members include first and second stimulator members which are movable relative to the housing and are interconnected to move axially in mutually opposite directions.
  16. 16. The device according to claim 15 wherein the first and second stimulator members are interconnected by levers, each lever being pivoted intermediate its ends for rotation about an axis extending orthogonally relative to the longitudinal axis of the housing.
  17. 17. The device according to claim 13, wherein the stimulator member and the plurality of levers are movable relative to the housing and a interconnected to move axially in mutually opposite directions.
  18. 18. The device according to claim 9 wherein the stimulator member comprises a helical spring.
  19. 19. The device according to claim 9 further including a second stimulator chosen from the group consisting of, a heating mechanism for heating the stimulator member or levers, a vibrator mechanism for vibrating the stimulator member or levers.
  20. 20. The device according to claim 9, wherein the plurality of levers are circumferentially disposed about a distal end of the housing, wherein each lever pivots independently.
US09960806 1996-05-17 2001-09-21 Methods and apparatus for expressing body fluid from an incision Abandoned US20020010406A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
US1713396 true 1996-05-17 1996-05-17
US1991896 true 1996-06-14 1996-06-14
US2365896 true 1996-08-01 1996-08-01
US2534096 true 1996-09-03 1996-09-03
US71454896 true 1996-09-16 1996-09-16
US71045696 true 1996-09-17 1996-09-17
US09586969 US6319210B1 (en) 1996-05-17 2000-06-05 Methods and apparatus for expressing body fluid from an incision
US09960806 US20020010406A1 (en) 1996-05-17 2001-09-21 Methods and apparatus for expressing body fluid from an incision

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09960806 US20020010406A1 (en) 1996-05-17 2001-09-21 Methods and apparatus for expressing body fluid from an incision
US10607347 US7841991B2 (en) 1996-05-17 2003-06-26 Methods and apparatus for expressing body fluid from an incision
US12938784 US20110046515A1 (en) 1996-05-17 2010-11-03 Methods and apparatus for expressing body fluid from an incision
US13561672 US8740813B2 (en) 1996-05-17 2012-07-30 Methods and apparatus for expressing body fluid from an incision

Related Parent Applications (3)

Application Number Title Priority Date Filing Date
US71454896 Continuation 1996-09-16 1996-09-16
US71045696 Continuation 1996-09-17 1996-09-17
US09586969 Continuation US6319210B1 (en) 1996-05-17 2000-06-05 Methods and apparatus for expressing body fluid from an incision

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10607347 Continuation US7841991B2 (en) 1996-05-17 2003-06-26 Methods and apparatus for expressing body fluid from an incision

Publications (1)

Publication Number Publication Date
US20020010406A1 true true US20020010406A1 (en) 2002-01-24

Family

ID=27567562

Family Applications (4)

Application Number Title Priority Date Filing Date
US09960806 Abandoned US20020010406A1 (en) 1996-05-17 2001-09-21 Methods and apparatus for expressing body fluid from an incision
US10607347 Active 2022-01-13 US7841991B2 (en) 1996-05-17 2003-06-26 Methods and apparatus for expressing body fluid from an incision
US12938784 Abandoned US20110046515A1 (en) 1996-05-17 2010-11-03 Methods and apparatus for expressing body fluid from an incision
US13561672 Expired - Lifetime US8740813B2 (en) 1996-05-17 2012-07-30 Methods and apparatus for expressing body fluid from an incision

Family Applications After (3)

Application Number Title Priority Date Filing Date
US10607347 Active 2022-01-13 US7841991B2 (en) 1996-05-17 2003-06-26 Methods and apparatus for expressing body fluid from an incision
US12938784 Abandoned US20110046515A1 (en) 1996-05-17 2010-11-03 Methods and apparatus for expressing body fluid from an incision
US13561672 Expired - Lifetime US8740813B2 (en) 1996-05-17 2012-07-30 Methods and apparatus for expressing body fluid from an incision

Country Status (1)

Country Link
US (4) US20020010406A1 (en)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040260180A1 (en) * 2001-08-20 2004-12-23 Hiroshi Kanai Tissue identifying method in ultrasonography and ultrasonograph
US20050234368A1 (en) * 2004-04-15 2005-10-20 Daniel Wong Integrated spot monitoring device with fluid sensor
US20060161077A1 (en) * 2003-06-23 2006-07-20 Masao Takinami Body fluid sampling implement and body fluid sampling method
US20070112367A1 (en) * 2005-11-17 2007-05-17 Olson Lorin P Method for lancing a dermal tissue target site using a cap with revolving body
US20080027474A1 (en) * 2006-06-15 2008-01-31 Abbott Diabetes Care Inc. Adjustable Lancing Devices and Methods
US20090312669A1 (en) * 2004-10-27 2009-12-17 Abbott Laboratories Blood Expression Device
US20100042128A1 (en) * 2008-08-14 2010-02-18 Abbott Diabetes Care Inc. Cap for lancing device with adjustable mode of operation
US20100042129A1 (en) * 2008-08-14 2010-02-18 Abbott Diabetes Care Inc. Adjustable cap and lancing device and method of use
US20100113981A1 (en) * 2008-05-09 2010-05-06 Panasonic Corporation Skin incision instrument and method for incising skin with the same
US20100268259A1 (en) * 2008-05-13 2010-10-21 Panasonic Corporation Skin incision instrument and method for incising skin with the same
US20100286467A1 (en) * 2007-03-19 2010-11-11 Benny Pesach Device for drug delivery and associated connections thereto
US20120065487A1 (en) * 2010-09-07 2012-03-15 Innova Medical Design LLC Systems, methods, and devices for reducing the pain of glucose monitoring and insulin adminstration in diabetic patients
US20120245497A1 (en) * 2009-11-09 2012-09-27 Owen Mumford Limited Skin stimulus
US9220837B2 (en) 2007-03-19 2015-12-29 Insuline Medical Ltd. Method and device for drug delivery

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7052652B2 (en) 2003-03-24 2006-05-30 Rosedale Medical, Inc. Analyte concentration detection devices and methods
EP1768571B1 (en) * 2004-07-09 2012-03-21 Bard Peripheral Vascular, Inc. Firing system for biopsy device
US7517321B2 (en) 2005-01-31 2009-04-14 C. R. Bard, Inc. Quick cycle biopsy system
US20060281187A1 (en) 2005-06-13 2006-12-14 Rosedale Medical, Inc. Analyte detection devices and methods with hematocrit/volume correction and feedback control
EP1921998A4 (en) 2005-08-10 2017-07-19 C.R.Bard, Inc. Single-insertion, multiple sampling biopsy device with linear drive
US20070073191A1 (en) * 2005-09-26 2007-03-29 Anne Thomson Device for promoting bodily fluid expression from a target site
US8801631B2 (en) 2005-09-30 2014-08-12 Intuity Medical, Inc. Devices and methods for facilitating fluid transport
EP2989981B8 (en) 2005-09-30 2018-09-05 Intuity Medical, Inc. Multi-site body fluid sampling and analysis cartridge
WO2009011138A1 (en) * 2007-07-18 2009-01-22 Panasonic Corporation Piercing device, blood inspection device, and piercing method
US8241225B2 (en) 2007-12-20 2012-08-14 C. R. Bard, Inc. Biopsy device
WO2009104765A1 (en) * 2008-02-21 2009-08-27 テルモ株式会社 Puncture tool with mechanism for relieving needle puncture pain and tool for relieving needle puncture pain
EP2293719B1 (en) * 2008-05-30 2015-09-09 Intuity Medical, Inc. Body fluid sampling device -- sampling site interface
CA2726067A1 (en) 2008-06-06 2009-12-10 Intuity Medical, Inc. Detection meter and mode of operation
US9173641B2 (en) 2009-08-12 2015-11-03 C. R. Bard, Inc. Biopsy apparatus having integrated thumbwheel mechanism for manual rotation of biopsy cannula
US8430824B2 (en) 2009-10-29 2013-04-30 Bard Peripheral Vascular, Inc. Biopsy driver assembly having a control circuit for conserving battery power
US8919605B2 (en) 2009-11-30 2014-12-30 Intuity Medical, Inc. Calibration material delivery devices and methods
US8696640B2 (en) * 2011-01-10 2014-04-15 Russell Churchill Snake venom evacuation and medication injection device
WO2013020103A1 (en) 2011-08-03 2013-02-07 Intuity Medical, Inc. Devices and methods for body fluid sampling and analysis
CN103211602B (en) * 2012-01-19 2014-11-12 华广生技股份有限公司 Blood lancing device
US20170049942A1 (en) * 2015-08-20 2017-02-23 Purecraft LLC Liposuction device and system and use thereof

Family Cites Families (433)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US720906A (en) 1902-11-17 1903-02-17 Charles Eilrich Trench-filler.
US1275414A (en) * 1917-08-28 1918-08-13 Gilbert D Forbes Surgical clamp.
US1960889A (en) 1932-08-13 1934-05-29 Samuel R Benedict Snake bite outfit
US2594621A (en) 1950-08-03 1952-04-29 George W Derrick Blood obtaining instrument
US2646799A (en) * 1951-02-14 1953-07-28 Jr George W Jacoby Blood lancet
US2714890A (en) * 1953-08-06 1955-08-09 Vang Alfred Vibratory surgical instruments
US3086288A (en) * 1955-04-20 1963-04-23 Cavitron Ultrasonics Inc Ultrasonically vibrated cutting knives
US3030959A (en) * 1959-09-04 1962-04-24 Praemeta Surgical lancet for blood sampling
US3068868A (en) 1960-06-08 1962-12-18 Skopyk Joseph Poison extractor
US3040744A (en) 1960-06-17 1962-06-26 Kenneth A Hoggard Syringe plunger ejector
US3208452A (en) * 1960-09-08 1965-09-28 Panray Parlam Corp Surface treating device
US3221739A (en) 1962-03-26 1965-12-07 Rosenthal Sol Roy Injection device
US3235337A (en) * 1962-10-22 1966-02-15 Miles Lab Diagnostic compositions and test indicators
US3358689A (en) 1964-06-09 1967-12-19 Roehr Products Company Inc Integral lancet and package
US3298789A (en) 1964-12-14 1967-01-17 Miles Lab Test article for the detection of glucose
US3486504A (en) 1967-11-20 1969-12-30 Lawthan M Austin Jr Device for applying dressing,medication and suction
US3623475A (en) 1968-07-26 1971-11-30 Micromedic Systems Inc Blood collector device
NL6909366A (en) 1968-07-26 1970-01-29
GB1323675A (en) 1969-07-09 1973-07-18 Nat Res Dev Endoscopes
US3640267A (en) 1969-12-15 1972-02-08 Damon Corp Clinical sample container
US3741197A (en) * 1970-09-04 1973-06-26 Micromedia Syst Inc Percussion apparatus for blood sampling
US3673475A (en) * 1970-09-15 1972-06-27 Fred M Hufnagel Pulse drive circuit for coils of dental impact tools and the like
DE2118455B (en) 1971-04-16 1972-09-21 Boehringer Mannheim Gmbh
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US3734085A (en) * 1971-07-30 1973-05-22 T Russell Stimulator
US3774611A (en) 1972-06-08 1973-11-27 J Tussey Stabilized contamination free surgical evacuator
US3832776A (en) * 1972-11-24 1974-09-03 H Sawyer Electronically powered knife
US3992158A (en) 1973-08-16 1976-11-16 Eastman Kodak Company Integral analytical element
US3933439A (en) 1974-04-29 1976-01-20 Mcdonald Bernard Blood collection device
DE2436598C2 (en) 1974-07-30 1983-04-07 Boehringer Mannheim Gmbh, 6800 Mannheim, De
US4042335A (en) 1975-07-23 1977-08-16 Eastman Kodak Company Integral element for analysis of liquids
DE2611721C3 (en) 1976-03-19 1979-06-21 R. Geerd Dr.Med. 6108 Weiterstadt Hamer
US4077406A (en) * 1976-06-24 1978-03-07 American Cyanamid Company Pellet implanter for animal treatment
US4154228A (en) * 1976-08-06 1979-05-15 California Institute Of Technology Apparatus and method of inserting a microelectrode in body tissue or the like using vibration means
DE2642896C3 (en) * 1976-09-24 1980-08-21 Sutor, Anton, Dr.Med.
CA1095819A (en) 1977-01-14 1981-02-17 Eastman Kodak Company Element for analysis of liquids
GB1599654A (en) 1977-08-05 1981-10-07 Holman R R Automatic lancet
US4222380A (en) * 1977-12-02 1980-09-16 Olympus Optical Co., Ltd. Celiac injector
US4223674A (en) 1978-06-29 1980-09-23 Arthur J. McIntosh Implant gun
JPS5810962B2 (en) * 1978-10-30 1983-02-28 Kawasaki Steel Co
US4235234A (en) 1978-11-30 1980-11-25 Martin John K Iii Subcutaneous injection system
US4258001A (en) 1978-12-27 1981-03-24 Eastman Kodak Company Element, structure and method for the analysis or transport of liquids
US4356826A (en) 1979-05-09 1982-11-02 Olympus Optical Co., Ltd. Stabbing apparatus for diagnosis of living body
DE3013384C2 (en) 1980-04-05 1988-04-07 Bernd Dr.Med. Tersteegen
US4360016A (en) 1980-07-01 1982-11-23 Transidyne General Corp. Blood collecting device
US4460354A (en) 1980-07-08 1984-07-17 Snyder Laboratories, Inc. Closed wound suction evacuator
US4441510A (en) * 1980-07-25 1984-04-10 Worley Michael W Method and apparatus for fetal pH scalp studies
GB2090659A (en) 1981-01-02 1982-07-14 Instrumentation Labor Inc Analytical device
US4535769A (en) 1981-03-23 1985-08-20 Becton, Dickinson And Company Automatic retractable lancet assembly
US4375815A (en) 1981-03-23 1983-03-08 Becton Dickinson And Company Retractable lancet assembly
US4397643A (en) 1981-05-04 1983-08-09 Sherwood Medical Company Drainage collection device with disposable liner
US4383530A (en) 1981-06-05 1983-05-17 John Bruno Hypodermic needle and method of making needles
FR2508305B1 (en) 1981-06-25 1986-04-11 Slama Gerard Device to cause a small bite to collect a drop of blood
US4503856A (en) * 1981-06-29 1985-03-12 Sherwood Medical Company Lancet injector
US4449529A (en) * 1981-11-18 1984-05-22 Becton Dickinson And Company Automatic retractable lancet assembly
US5073484A (en) 1982-03-09 1991-12-17 Bio-Metric Systems, Inc. Quantitative analysis apparatus and method
US4535773A (en) * 1982-03-26 1985-08-20 Inbae Yoon Safety puncturing instrument and method
DE3211167A1 (en) 1982-03-26 1983-09-29 Merck Patent Gmbh Test System and Method for the determination of substances in liquids
US4462405A (en) * 1982-09-27 1984-07-31 Ehrlich Joseph C Blood letting apparatus
CA1205731A (en) 1982-11-01 1986-06-10 Roger C. Phillips Test device and method for measurement of analyte levels in colored aqueous fluids
US4517978A (en) * 1983-01-13 1985-05-21 Levin Paul D Blood sampling instrument
USRE32922E (en) 1983-01-13 1989-05-16 Paul D. Levin Blood sampling instrument
CA1226036A (en) 1983-05-05 1987-08-25 Irving J. Higgins Analytical equipment and sensor electrodes therefor
US4580564A (en) 1983-06-07 1986-04-08 Andersen Michael A Finger pricking device
US4518384A (en) * 1983-06-17 1985-05-21 Survival Technology, Inc. Multiple medicament cartridge clip and medicament discharging device therefor
US4900666A (en) 1983-07-12 1990-02-13 Lifescan, Inc. Colorimetric ethanol analysis method and test device
US4734360A (en) 1983-07-12 1988-03-29 Lifescan, Inc. Colorimetric ethanol analysis method and test device
DK150403C (en) 1983-07-15 1987-07-13 Radiometer As Blodproevetagningsudstyr
DE3426090A1 (en) 1983-10-06 1985-04-18 Storz Karl Gmbh & Co Obstetric apparatus
EP0159355A1 (en) 1983-10-17 1985-10-30 Inomedix, Incorporated Device for rapid quantitative analysis of a fluid
US4637978A (en) * 1983-10-28 1987-01-20 Eastman Kodak Company Assay for analysis of whole blood
DE3340929A1 (en) 1983-11-11 1985-05-23 Bayer Ag A process for the preparation of carbon monoxide
US4577630A (en) * 1984-02-14 1986-03-25 Becton, Dickinson And Co. Reusable breach loading target pressure activated lancet firing device
US4562842A (en) 1984-02-21 1986-01-07 Diane E. Morfeld Blood-loss measurement apparatus
DE3407359A1 (en) 1984-02-29 1985-08-29 Bayer Ag Test device and method for detecting a component of a liquid sample
US4622974A (en) 1984-03-07 1986-11-18 University Of Tennessee Research Corporation Apparatus and method for in-vivo measurements of chemical concentrations
GB8406154D0 (en) 1984-03-09 1984-04-11 Palmer G C Sampling fluid
NL8401536A (en) 1984-05-11 1985-12-02 Medscan B V I O Blood Sampler.
DE3508365A1 (en) 1984-06-14 1985-12-19 Weise Gustav Watch with a bracelet consisting of a plurality of links
EP0166574A3 (en) 1984-06-28 1987-06-16 Mitchell P. Dombrowski, M.D. Fetal blood sampling instrument
US4616649A (en) 1984-09-20 1986-10-14 Becton, Dickinson And Company Lancet
US4826759A (en) 1984-10-04 1989-05-02 Bio-Metric Systems, Inc. Field assay for ligands
US4653511A (en) 1984-10-05 1987-03-31 Goch Thomas A Microsample blood collecting device
DE3581397D1 (en) 1985-04-01 1991-02-21 Cosmed Srl Portable atemueberwachungsgeraet for telemetry of measured values ​​from a data processing center.
US4787398A (en) 1985-04-08 1988-11-29 Garid, Inc. Glucose medical monitoring system
US4627445A (en) * 1985-04-08 1986-12-09 Garid, Inc. Glucose medical monitoring system
US5279294A (en) * 1985-04-08 1994-01-18 Cascade Medical, Inc. Medical diagnostic system
US4678757A (en) 1985-04-11 1987-07-07 Smithkline Diagnostics, Inc. Device and method for whole blood separation and analysis
US4653513A (en) * 1985-08-09 1987-03-31 Dombrowski Mitchell P Blood sampler
US4750489A (en) * 1985-08-29 1988-06-14 Coopervision, Inc. Radial keratotomy knife and system using same
DE3708031A1 (en) 1986-03-20 1987-11-12 Wolfgang Dr Med Wagner Measurement device or induction device with measurement device, or device for material recovery for a measurement device for metabolic states in the blood by puncturing under reduced pressure in a suction cup with displacement of the measurement zone outside the tip region of the puncturing device
US4839296A (en) 1985-10-18 1989-06-13 Chem-Elec, Inc. Blood plasma test method
FR2590673B1 (en) 1985-11-05 1988-09-16 Bally Philippe Device independent test miniaturized single use
ES2003744A6 (en) * 1985-11-18 1988-11-16 Bajada Serge An apparatus for testing the sensory system in humans or animals
US4658821A (en) * 1986-01-08 1987-04-21 Packaging Corporation International A/K/A/ Medicore Ejector for an automatic lancet arm
US4906439A (en) 1986-03-25 1990-03-06 Pb Diagnostic Systems, Inc. Biological diagnostic device and method of use
US4685463A (en) * 1986-04-03 1987-08-11 Williams R Bruce Device for continuous in vivo measurement of blood glucose concentrations
US4994167A (en) 1986-04-15 1991-02-19 Markwell Medical Institute, Inc. Biological fluid measuring device
US4837049A (en) 1986-06-17 1989-06-06 Alfred E. Mann Foundation For Scientific Research Method of making an electrode array
US4772264A (en) 1986-06-23 1988-09-20 Regents Of The University Of Minnesota Catheter introduction set
US5029583A (en) 1986-07-22 1991-07-09 Personal Diagnostics, Inc. Optical analyzer
US4873993A (en) 1986-07-22 1989-10-17 Personal Diagnostics, Inc. Cuvette
US5049487A (en) 1986-08-13 1991-09-17 Lifescan, Inc. Automated initiation of timing of reflectance readings
US4935346A (en) 1986-08-13 1990-06-19 Lifescan, Inc. Minimum procedure system for the determination of analytes
US4790979A (en) 1986-08-29 1988-12-13 Technimed Corporation Test strip and fixture
GB8818491D0 (en) 1987-09-08 1988-09-07 Wagner W Device for control of metabolism especially of diabetes
US5178831A (en) 1986-10-08 1993-01-12 Dai Nippon Insatsu Kab Ushiki Kaisha Device for testing body fluids
US4794926A (en) * 1986-11-24 1989-01-03 Invictus, Inc. Lancet cartridge
US5102404A (en) 1986-12-15 1992-04-07 Uresil Corporation Apparatus and method for collecting body fluids
US5019059A (en) 1986-12-15 1991-05-28 Uresil Corporation Apparatus and method for collecting body fluids
US5002054A (en) 1987-02-25 1991-03-26 Ash Medical Systems, Inc. Interstitial filtration and collection device and method for long-term monitoring of physiological constituents of the body
GB8710470D0 (en) 1987-05-01 1987-06-03 Mumford Ltd Owen Blood sampling devices
US4805623A (en) * 1987-09-04 1989-02-21 Vander Corporation Spectrophotometric method for quantitatively determining the concentration of a dilute component in a light- or other radiation-scattering environment
US4850973A (en) * 1987-10-16 1989-07-25 Pavel Jordon & Associates Plastic device for injection and obtaining blood samples
US4818677A (en) 1987-12-03 1989-04-04 Monoclonal Antibodies, Inc. Membrane assay using focused sample application
US4844095A (en) 1987-12-14 1989-07-04 Medicore, Inc. Automatic lancet device
US5014718A (en) * 1988-01-22 1991-05-14 Safety Diagnostics, Inc. Blood collection and testing method
US5070886A (en) 1988-01-22 1991-12-10 Safety Diagnostice, Inc. Blood collection and testing means
US4883068A (en) 1988-03-14 1989-11-28 Dec In Tech, Inc. Blood sampling device and method
US5164294A (en) 1988-05-17 1992-11-17 Syntex (U.S.A.) Inc. Method for immunochromatographic analysis
US4999287A (en) 1988-05-19 1991-03-12 Chemtrak Corporation Direct measuring assay strip and method of use thereof
US4994238A (en) 1988-06-09 1991-02-19 Daffern George M Constant volume chemical analysis test device
US4981473A (en) 1988-06-22 1991-01-01 Rosenblatt/Ima Invention Enterprises Aspirator without partition wall for collection of bodily fluids including improved safety and efficiency elements
US4925447A (en) 1988-06-22 1990-05-15 Rosenblatt/Ima Invention Enterprises Aspirator without partition wall for collection of bodily fluids including improved safety and efficiency elements
US5320808A (en) * 1988-08-02 1994-06-14 Abbott Laboratories Reaction cartridge and carousel for biological sample analyzer
US4924879A (en) 1988-10-07 1990-05-15 Brien Walter J O Blood lancet device
US4995402A (en) 1988-10-12 1991-02-26 Thorne, Smith, Astill Technologies, Inc. Medical droplet whole blood and like monitoring
US4920977A (en) 1988-10-25 1990-05-01 Becton, Dickinson And Company Blood collection assembly with lancet and microcollection tube
US4895147A (en) 1988-10-28 1990-01-23 Sherwood Medical Company Lancet injector
JP2689531B2 (en) 1988-10-31 1997-12-10 エヌオーケー株式会社 Glucose sensor
US4983178A (en) 1988-11-14 1991-01-08 Invictus, Inc. Lancing device
JPH02170388A (en) 1988-12-23 1990-07-02 Kyocera Corp Temperature control method for object to be heated
US5202268A (en) 1988-12-30 1993-04-13 Environmental Diagnostics, Inc. Multi-layered test card for the determination of substances in liquids
US4994073A (en) 1989-02-22 1991-02-19 United States Surgical Corp. Skin fastener
US5035704A (en) * 1989-03-07 1991-07-30 Lambert Robert D Blood sampling mechanism
CA1337167C (en) 1989-03-14 1995-10-03 Eastman Kodak Company Needle housing with retractable needle
US5054499A (en) 1989-03-27 1991-10-08 Swierczek Remi D Disposable skin perforator and blood testing device
US5402798A (en) 1991-07-18 1995-04-04 Swierczek; Remi Disposable skin perforator and blood testing device
US4953552A (en) 1989-04-21 1990-09-04 Demarzo Arthur P Blood glucose monitoring system
US5145565A (en) 1989-05-01 1992-09-08 Spacelabs, Inc. Contamination-free method and apparatus for measuring body fluid chemical parameters
US5100620A (en) 1989-05-15 1992-03-31 Miles, Inc. Capillary tube/gap reagent format
ES2070264T3 (en) 1989-06-05 1995-06-01 Janssen Pharmaceutica Nv A solid phase assay for use with a physical developer.
US4990154A (en) 1989-06-19 1991-02-05 Miles Inc. Lancet assembly
US4994079A (en) * 1989-07-28 1991-02-19 C. R. Bard, Inc. Grasping forceps
US4976724A (en) 1989-08-25 1990-12-11 Lifescan, Inc. Lancet ejector mechanism
EP0415679A3 (en) 1989-08-28 1991-07-03 Lifescan Inc Blood separation and analyte detection techniques
US5306623A (en) 1989-08-28 1994-04-26 Lifescan, Inc. Visual blood glucose concentration test strip
US5620863A (en) 1989-08-28 1997-04-15 Lifescan, Inc. Blood glucose strip having reduced side reactions
US5026388A (en) * 1989-09-26 1991-06-25 Ingalz Thomas J Single-use skin puncture device
DE4033741C2 (en) 1989-11-02 1994-03-31 Falko Volkhardt E Dipl Tittel Device for the detection of HIV antibodies in whole blood displaying result
US5415169A (en) * 1989-11-21 1995-05-16 Fischer Imaging Corporation Motorized mammographic biopsy apparatus
US4994068A (en) 1989-11-24 1991-02-19 Unidex, Inc. Combination sterile pad support and lancet containing lancet disposal element
US5762770A (en) 1994-02-21 1998-06-09 Boehringer Mannheim Corporation Electrochemical biosensor test strip
US5252496A (en) 1989-12-18 1993-10-12 Princeton Biomeditech Corporation Carbon black immunochemical label
US5052403A (en) 1989-12-29 1991-10-01 Habley Medical Technology Corporation Self-contained, safety blood collection system
US5250066A (en) 1990-03-19 1993-10-05 Becton Dickinson And Company Plastic pointed articles and method for their preparation
US5223220A (en) 1990-03-27 1993-06-29 Pacific Biotech, Inc. Solid phase immunoassay device and method of making same
US5271385A (en) * 1990-03-29 1993-12-21 United States Surgical Corporation Abdominal cavity organ retractor
US5097810A (en) * 1990-04-06 1992-03-24 Henry Fishman Allergy testing apparatus and method
US5161532A (en) 1990-04-19 1992-11-10 Teknekron Sensor Development Corporation Integral interstitial fluid sensor
DE4015590A1 (en) 1990-05-15 1991-11-21 Boehringer Mannheim Gmbh Testtraeger for determination of ion
US5066859A (en) 1990-05-18 1991-11-19 Karkar Maurice N Hematocrit and oxygen saturation blood analyzer
US5187100A (en) 1990-05-29 1993-02-16 Lifescan, Inc. Dispersion to limit penetration of aqueous solutions into a membrane
US5096833A (en) 1990-05-29 1992-03-17 Miles Inc. Method and device for determining protein using carrier matrix composed of urethane, water insouble inorganic compound and insoluble organic compound and method of making the device
US5147606A (en) 1990-08-06 1992-09-15 Miles Inc. Self-metering fluid analysis device
US5565170A (en) 1990-08-30 1996-10-15 Kyoto Daiichi Kagaku Co., Ltd. Multilayer analytical element for assaying fructosamine
US5152775A (en) 1990-10-04 1992-10-06 Norbert Ruppert Automatic lancet device and method of using the same
CA2095240A1 (en) 1990-10-30 1992-05-01 Stephen J. Cox Collection and display device
US5188118A (en) * 1990-11-07 1993-02-23 Terwilliger Richard A Automatic biopsy instrument with independently actuated stylet and cannula
JPH04194660A (en) 1990-11-27 1992-07-14 Omron Corp Device for measuring concentration of component in blood
US5360410A (en) 1991-01-16 1994-11-01 Senetek Plc Safety syringe for mixing two-component medicaments
US5189751A (en) * 1991-03-21 1993-03-02 Gemtech, Inc. Vibrating toothbrush using a magnetic driver
US5133730A (en) 1991-05-15 1992-07-28 International Technidyne Corporation Disposable-retractable finger stick device
DE4117847A1 (en) 1991-05-31 1992-12-03 Lre Relais & Elektronik Gmbh Evaluating bar coded optical information - subjecting output from sensor to peak and min. valve generation with comparison process
US5163442A (en) 1991-07-30 1992-11-17 Harry Ono Finger tip blood collector
US5195534A (en) 1991-08-16 1993-03-23 Helena Laboratories Corporation Biological fluid collection and dispensing apparatus and method
US5607401A (en) 1991-09-03 1997-03-04 Humphrey; Bruce H. Augmented polymeric hypodermic devices
WO1993009723A1 (en) 1991-11-12 1993-05-27 Ramel Urs A Lancet device
US5231993A (en) 1991-11-20 1993-08-03 Habley Medical Technology Corporation Blood sampler and component tester with guide member
US5334502A (en) 1991-11-27 1994-08-02 Osborn Laboratories, Inc. Method of collecting, identifying, and quantifying saliva
DE4142795C1 (en) 1991-12-23 1993-04-22 Steinweg, Friedhelm, Dr.Med., 4750 Unna, De
US6436078B1 (en) 1994-12-06 2002-08-20 Pal Svedman Transdermal perfusion of fluids
DE4202850A1 (en) 1992-01-31 1993-08-05 Boehringer Mannheim Gmbh Analytical element for immunoassays
US5279586A (en) 1992-02-04 1994-01-18 Becton, Dickinson And Company Reusable medication delivery pen
US5222504A (en) * 1992-02-11 1993-06-29 Solomon Charles L Disposable neurological pinwheel
JP2572823Y2 (en) 1992-02-13 1998-05-25 株式会社アドバンス Simple blood collection device
US5165418B1 (en) 1992-03-02 1999-12-14 Nikola I Tankovich Blood sampling device and method using a laser
GB9207120D0 (en) 1992-04-01 1992-05-13 Owen Mumford Ltd Improvements relating to blood sampling devices
DE4212315A1 (en) 1992-04-13 1993-10-14 Boehringer Mannheim Gmbh Blood lancet device for withdrawing blood for diagnostic purposes
JPH0610900A (en) 1992-04-27 1994-01-21 Canon Inc Method and device for moving liquid and measuring device utilizing these method and device
US5309924A (en) 1992-04-29 1994-05-10 Peabody Alan M Spill-proof blood collection device
US5318583A (en) 1992-05-05 1994-06-07 Ryder International Corporation Lancet actuator mechanism
DE4217733A1 (en) 1992-05-29 1993-12-02 Boehringer Mannheim Gmbh Test carrier for the determination of analytes and to methods for its preparation
US5217480A (en) 1992-06-09 1993-06-08 Habley Medical Technology Corporation Capillary blood drawing device
US5277198A (en) 1992-07-27 1994-01-11 Ryder International Corporation Blood sampling syringe
US5290420A (en) 1992-08-12 1994-03-01 Esa, Inc. Sampling system and analysis cell for stripping voltammetry
US5354692A (en) 1992-09-08 1994-10-11 Pacific Biotech, Inc. Analyte detection device including a hydrophobic barrier for improved fluid flow
CA2079192C (en) 1992-09-25 1995-12-26 Bernard Strong Combined lancet and multi-function cap and lancet injector for use therewith
US5324302A (en) 1992-10-13 1994-06-28 Sherwood Medical Company Lancet with locking cover
US5421816A (en) 1992-10-14 1995-06-06 Endodermic Medical Technologies Company Ultrasonic transdermal drug delivery system
US5314441A (en) 1992-10-16 1994-05-24 International Technidyne Corporation Disposable slicing lancet assembly
JP3144718B2 (en) 1992-10-26 2001-03-12 アプルス株式会社 Blood collection device
US5269800A (en) 1992-12-10 1993-12-14 Davis Manufacturing Systems Inc. Blood lancing device
US5282822A (en) 1993-01-19 1994-02-01 Sherwood Medical Company Lancet ejector for lancet injector
CA2153593C (en) 1993-01-26 2010-04-13 David B. Weiner Compositions and methods for delivery of genetic material
US5529074A (en) * 1993-02-26 1996-06-25 Greenfield; Jon B. Uniform pressure diagnostic pinwheel
US5395387A (en) 1993-02-26 1995-03-07 Becton Dickinson And Company Lancet blade designed for reduced pain
US5353806A (en) 1993-03-04 1994-10-11 The Venture Fund Of Washington Liquid collection device
US5902279A (en) * 1993-04-20 1999-05-11 Advanced Cytometrix, Inc. Aspiration needle and method
DE4313253A1 (en) 1993-04-23 1994-10-27 Boehringer Mannheim Gmbh System for the analysis of liquid samples ingredients
EP0622626B1 (en) * 1993-04-23 2002-03-06 Boehringer Mannheim Gmbh System for analysing the components of fluid samples
JP2630197B2 (en) 1993-04-28 1997-07-16 株式会社ニッショー Blood suction device
US5843691A (en) 1993-05-15 1998-12-01 Lifescan, Inc. Visually-readable reagent test strip
DE4318142C2 (en) 1993-06-02 1995-07-06 Richard Herbst Lancet device for preparing a blood sample
DE4320463A1 (en) 1993-06-21 1994-12-22 Boehringer Mannheim Gmbh Blood lancet device for withdrawing blood for diagnostic purposes
US5387203A (en) 1993-06-28 1995-02-07 Goodrich; Hubert J. Subcutaneous extractor
CA2127172C (en) 1993-08-05 1998-07-14 Amy H. Chu Analyte detection device and process
JP3494183B2 (en) 1993-08-10 2004-02-03 株式会社アドバンス Simple blood collection device
US5304193A (en) 1993-08-12 1994-04-19 Sam Zhadanov Blood lancing device
WO1995006240A1 (en) 1993-08-24 1995-03-02 Metrika Laboratories, Inc. Novel disposable electronic assay device
US5522255A (en) 1993-08-31 1996-06-04 Boehringer Mannheim Corporation Fluid dose, flow and coagulation sensor for medical instrument
US5582184A (en) 1993-10-13 1996-12-10 Integ Incorporated Interstitial fluid collection and constituent measurement
WO1995010977A1 (en) 1993-10-20 1995-04-27 Varro, Anne, Marie Lancet device with irretrievably retractable piercing member
US5472427A (en) 1993-10-22 1995-12-05 Rammler; David H. Trocar device
WO1995011621A1 (en) 1993-10-28 1995-05-04 I-Stat Corporation Fluid sample collection and introduction device
US5458140A (en) 1993-11-15 1995-10-17 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers
US5885211A (en) * 1993-11-15 1999-03-23 Spectrix, Inc. Microporation of human skin for monitoring the concentration of an analyte
US5445611A (en) 1993-12-08 1995-08-29 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal delivery with ultrasound and chemical enhancers
US5439473A (en) 1993-12-13 1995-08-08 Modulohm A/S Safety lancet
US5423758A (en) 1993-12-16 1995-06-13 Shaw; Thomas J. Retractable fluid collection device
US5397334A (en) 1994-01-11 1995-03-14 Sherwood Medical Company Distal movement limiting assembly for finger stick device
US5437640A (en) 1994-01-31 1995-08-01 Schwab; Louis Apparatus and method for inserting hypodermic, tuberculin and other needles and for administering Mantoux tuberculin tests
US5549584A (en) 1994-02-14 1996-08-27 The Kendall Company Apparatus for removing fluid from a wound
US5437999A (en) 1994-02-22 1995-08-01 Boehringer Mannheim Corporation Electrochemical sensor
US5725831A (en) 1994-03-14 1998-03-10 Becton Dickinson And Company Nucleic acid amplification apparatus
US5474084A (en) 1994-03-15 1995-12-12 Cunniff; Joseph G. Algesimeter with detachable pin wheel
US5556761A (en) 1994-04-26 1996-09-17 Phillips; Kevin J. Test strip for blood glucose testing
DE4415896A1 (en) 1994-05-05 1995-11-09 Boehringer Mannheim Gmbh Analysis system for monitoring the concentration of an analyte in the blood of a patient
JP3368985B2 (en) 1994-05-10 2003-01-20 バイエルコーポレーション Automatic feeder
US5529581A (en) 1994-05-17 1996-06-25 International Technidyne Corporation Lancet device for creating a skin incision
US5591139A (en) * 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
JP2723048B2 (en) 1994-06-24 1998-03-09 株式会社ニッショー Blood suction device
US5700695A (en) 1994-06-30 1997-12-23 Zia Yassinzadeh Sample collection and manipulation method
US5547702A (en) 1994-07-08 1996-08-20 Polymer Technology International Corporation Method for continuous manufacture of diagnostic test strips
US5569212A (en) 1994-07-22 1996-10-29 Raya Systems, Inc. Apparatus for electrically determining injection doses in syringes
US5476474A (en) 1994-07-27 1995-12-19 Ryder International Corporation Rotary lancet
US5518006A (en) 1994-08-09 1996-05-21 International Technidyne Corp. Blood sampling device
US5514152A (en) * 1994-08-16 1996-05-07 Specialized Health Products, Inc. Multiple segment encapsulated medical lancing device
US5563031A (en) 1994-09-08 1996-10-08 Lifescan, Inc. Highly stable oxidative coupling dye for spectrophotometric determination of analytes
US5526120A (en) 1994-09-08 1996-06-11 Lifescan, Inc. Test strip with an asymmetrical end insuring correct insertion for measuring
US5515170A (en) 1994-09-08 1996-05-07 Lifescan, Inc. Analyte detection device having a serpentine passageway for indicator strips
US5504011A (en) 1994-10-21 1996-04-02 International Technidyne Corporation Portable test apparatus and associated method of performing a blood coagulation test
GB9422260D0 (en) 1994-11-04 1994-12-21 Owen Mumford Ltd Improvements relating to skin prickers
US5628765A (en) 1994-11-29 1997-05-13 Apls Co., Ltd. Lancet assembly
US5947957A (en) 1994-12-23 1999-09-07 Jmar Technology Co. Portable laser for blood sampling
US5630986A (en) * 1995-01-13 1997-05-20 Bayer Corporation Dispensing instrument for fluid monitoring sensors
US5575403A (en) * 1995-01-13 1996-11-19 Bayer Corporation Dispensing instrument for fluid monitoring sensors
US5810199A (en) 1996-06-10 1998-09-22 Bayer Corporation Dispensing instrument for fluid monitoring sensor
US5655542A (en) * 1995-01-26 1997-08-12 Weilandt; Anders Instrument and apparatus for biopsy and a method thereof
US5636640A (en) 1995-02-06 1997-06-10 Volunteers For Medical Engineering Liquid sampling and test apparatus
US5668017A (en) 1995-02-10 1997-09-16 Path Radial absorption device
US5512158A (en) 1995-02-28 1996-04-30 Hewlett-Packard Company Capillary electrophoresis method and apparatus for electric field uniformity and minimal dispersion of sample fractions
US5628764A (en) 1995-03-21 1997-05-13 Schraga; Steven Collar lancet device
JP3491863B2 (en) 1995-03-27 2004-01-26 ライフスキヤン・インコーポレーテツド Chemical timer for a direct-reading reagent test strips
JP3836510B2 (en) 1995-04-12 2006-10-25 ライフスキャン・インコーポレイテッド Defining method of the electrode area
CA2170560C (en) * 1995-04-17 2005-10-25 Joseph L. Moulton Means of handling multiple sensors in a glucose monitoring instrument system
US5510266A (en) 1995-05-05 1996-04-23 Bayer Corporation Method and apparatus of handling multiple sensors in a glucose monitoring instrument system
US5712172A (en) 1995-05-18 1998-01-27 Wyntek Diagnostics, Inc. One step immunochromatographic device and method of use
WO1996037256A1 (en) 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
JPH08317917A (en) * 1995-05-25 1996-12-03 Advance Co Ltd Blood drawing device
KR0135178Y1 (en) 1995-06-26 1999-03-20 김인환 Lancet device for obtaining blood samples
US5671753A (en) 1995-06-27 1997-09-30 Pitesky; Isadore Disposable multiple allergen testing apparatus
US5730753A (en) 1995-07-28 1998-03-24 Apls Co., Ltd. Assembly for adjusting pricking depth of lancet
CA2182545A1 (en) 1995-08-03 1997-02-04 Joel Douglas Direct-reading reagent test strip
US5709699A (en) 1995-09-01 1998-01-20 Biosafe Diagnostics Corporation Blood collection and testing device
US5879310A (en) 1995-09-08 1999-03-09 Integ, Inc. Body fluid sampler
US5682233A (en) 1995-09-08 1997-10-28 Integ, Inc. Interstitial fluid sampler
US5879367A (en) 1995-09-08 1999-03-09 Integ, Inc. Enhanced interstitial fluid collection
EP0955883B1 (en) 1995-09-20 2002-07-31 California Institute of Technology Detecting thermal discrepancies in vessel walls
JP3685530B2 (en) * 1995-09-20 2005-08-17 大日本印刷株式会社 Blood analyzer
CA2187861C (en) 1995-10-17 2007-04-10 Yeung S. Yu Blood glucose strip having reduced sensitivity to hematocrit
US5779642A (en) 1996-01-16 1998-07-14 Nightengale; Christopher Interrogation device and method
US5662127A (en) 1996-01-17 1997-09-02 Bio-Plas, Inc. Self-contained blood withdrawal apparatus and method
US5628309A (en) 1996-01-25 1997-05-13 Raya Systems, Inc. Meter for electrically measuring and recording injection syringe doses
DE19604156A1 (en) * 1996-02-06 1997-08-07 Boehringer Mannheim Gmbh Cutting device for skin for painless removal of small quantities of blood
US5916229A (en) * 1996-02-07 1999-06-29 Evans; Donald Rotating needle biopsy device and method
KR970050978U (en) 1996-02-23 1997-09-08 유태우 Bleeding needles
US5801057A (en) 1996-03-22 1998-09-01 Smart; Wilson H. Microsampling device and method of construction
CA2201570A1 (en) 1996-04-04 1997-10-04 John L. Smith Reagent test strip for determination of blood glucose
US5776719A (en) 1996-04-05 1998-07-07 Mercury Diagnostics, Inc. Diagnostic compositions and devices utilizing same
US5962215A (en) 1996-04-05 1999-10-05 Mercury Diagnostics, Inc. Methods for testing the concentration of an analyte in a body fluid
GB9607898D0 (en) 1996-04-17 1996-06-19 British Nuclear Fuels Plc Improvements in and relating to sensors
JP3098971B2 (en) 1996-05-15 2000-10-16 松下電工株式会社 Epilation device
ES2121565T6 (en) * 1996-05-17 1998-11-16 Mercury Diagnostics Inc A disposable device for use in a sampling of body fluids.
EP0955914B1 (en) 1996-05-17 2010-02-24 Roche Diagnostics Operations, Inc. Apparatus for sampling body fluid from an incision
US5824491A (en) 1996-05-17 1998-10-20 Mercury Diagnostics, Inc. Dry reagent test strip comprising benzidine dye precursor and antipyrine compound
US5951492A (en) 1996-05-17 1999-09-14 Mercury Diagnostics, Inc. Methods and apparatus for sampling and analyzing body fluid
US6015392A (en) 1996-05-17 2000-01-18 Mercury Diagnostics, Inc. Apparatus for sampling body fluid
US6332871B1 (en) 1996-05-17 2001-12-25 Amira Medical Blood and interstitial fluid sampling device
EP1579814A3 (en) 1996-05-17 2006-06-14 Roche Diagnostics Operations, Inc. Methods and apparatus for sampling and analyzing body fluid
WO1997042885A1 (en) 1996-05-17 1997-11-20 Mercury Diagnostics, Inc. Methods and apparatus for sampling body fluid
US5857983A (en) 1996-05-17 1999-01-12 Mercury Diagnostics, Inc. Methods and apparatus for sampling body fluid
US5879311A (en) 1996-05-17 1999-03-09 Mercury Diagnostics, Inc. Body fluid sampling device and methods of use
US5613978A (en) 1996-06-04 1997-03-25 Palco Laboratories Adjustable tip for lancet device
US5741288A (en) 1996-06-27 1998-04-21 Chemtrak, Inc. Re-armable single-user safety finger stick device having reset for multiple use by a single patient
CA2259437C (en) 1996-07-03 2006-12-05 Altea Technologies, Inc. Multiple mechanical microporation of skin or mucosa
US5758643A (en) * 1996-07-29 1998-06-02 Via Medical Corporation Method and apparatus for monitoring blood chemistry
FI112029B (en) * 1996-09-02 2003-10-31 Nokia Corp The device, such as receiving and analyzing blood samples in liquid samples
GB9619462D0 (en) 1996-09-18 1996-10-30 Owen Mumford Ltd Improvements relating to lancet devices
US5851215A (en) 1996-09-24 1998-12-22 International Technidyne Corporation Low cost disposable lancet
US6146361A (en) 1996-09-26 2000-11-14 Becton Dickinson And Company Medication delivery pen having a 31 gauge needle
US5776157A (en) * 1996-10-02 1998-07-07 Specialized Health Products, Inc. Lancet apparatus and methods
US5730357A (en) 1996-10-03 1998-03-24 Airboss Of America Corp. Railroad tie pad
US5935864A (en) 1996-10-07 1999-08-10 Saliva Diagnostic Systems Inc. Method and kit for collecting samples of liquid specimens for analytical testing
US5714390A (en) * 1996-10-15 1998-02-03 Bio-Tech Imaging, Inc. Cartridge test system for the collection and testing of blood in a single step
US5873887A (en) 1996-10-25 1999-02-23 Bayer Corporation Blood sampling device
ES2384705T3 (en) 1996-10-30 2012-07-11 F. Hoffmann-La Roche Ag synchronized analyte test system
DE19781288B4 (en) 1996-11-08 2005-09-29 Amira Medical, Scotts Valley Opaque response matrix for the analysis of whole blood
US6071251A (en) 1996-12-06 2000-06-06 Abbott Laboratories Method and apparatus for obtaining blood for diagnostic tests
US6063039A (en) 1996-12-06 2000-05-16 Abbott Laboratories Method and apparatus for obtaining blood for diagnostic tests
US5876957A (en) 1997-01-09 1999-03-02 Mercury Diagnostics, Inc. Methods for applying a reagent to an analytical test device
JP3394262B2 (en) 1997-02-06 2003-04-07 イー.ヘラー アンド カンパニー Small volume in vitro analyte sensor
US5913833A (en) * 1997-02-07 1999-06-22 Abbott Laboratories Method and apparatus for obtaining biological fluids
US5830219A (en) 1997-02-24 1998-11-03 Trex Medical Corporation Apparatus for holding and driving a surgical cutting device using stereotactic mammography guidance
US5788652A (en) 1997-03-24 1998-08-04 S&H Diagnostics, Inc. Blood sample collection device
US5968063A (en) 1997-05-14 1999-10-19 Jennifer Chu Intramuscular stimulation therapy facilitating device and method
US5951493A (en) 1997-05-16 1999-09-14 Mercury Diagnostics, Inc. Methods and apparatus for expressing body fluid from an incision
US5984940A (en) 1997-05-29 1999-11-16 Atrion Medical Products, Inc. Lancet device
US5916230A (en) 1997-06-16 1999-06-29 Bayer Corporation Blood sampling device with adjustable end cap
US5948695A (en) 1997-06-17 1999-09-07 Mercury Diagnostics, Inc. Device for determination of an analyte in a body fluid
FI111217B (en) 1997-06-19 2003-06-30 Nokia Corp Device for taking samples
US6056765A (en) 1997-06-24 2000-05-02 Bajaj; Ratan Lancet device
US6068599A (en) 1997-07-14 2000-05-30 Matsushita Electric Industrial Co., Ltd. Blood vessel puncturing device using ultrasound
US6019735A (en) 1997-08-28 2000-02-01 Visco Technologies, Inc. Viscosity measuring apparatus and method of use
US6090078A (en) 1997-09-30 2000-07-18 Becton, Dickinson And Company Dampening devices and methods for needle retracting safety vascular access devices
US5938679A (en) * 1997-10-14 1999-08-17 Hewlett-Packard Company Apparatus and method for minimally invasive blood sampling
US6013513A (en) 1997-10-30 2000-01-11 Motorola, Inc. Molecular detection apparatus
US5964718A (en) 1997-11-21 1999-10-12 Mercury Diagnostics, Inc. Body fluid sampling device
US6706000B2 (en) 1997-11-21 2004-03-16 Amira Medical Methods and apparatus for expressing body fluid from an incision
DE19824036A1 (en) * 1997-11-28 1999-06-02 Roche Diagnostics Gmbh Analytical instrument with lancing
US6155992A (en) 1997-12-02 2000-12-05 Abbott Laboratories Method and apparatus for obtaining interstitial fluid for diagnostic tests
US6036924A (en) * 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US6071294A (en) * 1997-12-04 2000-06-06 Agilent Technologies, Inc. Lancet cartridge for sampling blood
US5971941A (en) 1997-12-04 1999-10-26 Hewlett-Packard Company Integrated system and method for sampling blood and analysis
US5871494A (en) * 1997-12-04 1999-02-16 Hewlett-Packard Company Reproducible lancing for sampling blood
JP2001527216A (en) 1997-12-19 2001-12-25 アミラ メディカル Embossed test strip system
US6022324A (en) 1998-01-02 2000-02-08 Skinner; Bruce A. J. Biopsy instrument
US6306347B1 (en) 1998-01-21 2001-10-23 Bayer Corporation Optical sensor and method of operation
JP2000014662A (en) * 1998-01-22 2000-01-18 Terumo Corp Humor examination device
US6193673B1 (en) * 1998-02-20 2001-02-27 United States Surgical Corporation Biopsy instrument driver apparatus
US6261241B1 (en) * 1998-03-03 2001-07-17 Senorx, Inc. Electrosurgical biopsy device and method
US6139562A (en) * 1998-03-30 2000-10-31 Agilent Technologies, Inc. Apparatus and method for incising
US6391005B1 (en) * 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
DE59912876D1 (en) 1998-04-24 2006-01-12 Roche Diagnostics Gmbh Storage container for analytical tools
US6086545A (en) 1998-04-28 2000-07-11 Amira Medical Methods and apparatus for suctioning and pumping body fluid from an incision
US5951582A (en) 1998-05-22 1999-09-14 Specialized Health Products, Inc. Lancet apparatus and methods
US6346114B1 (en) 1998-06-11 2002-02-12 Stat Medical Devices, Inc. Adjustable length member such as a cap of a lancet device for adjusting penetration depth
US6022366A (en) 1998-06-11 2000-02-08 Stat Medical Devices Inc. Lancet having adjustable penetration depth
US6338790B1 (en) 1998-10-08 2002-01-15 Therasense, Inc. Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator
JP3902875B2 (en) 1998-10-19 2007-04-11 テルモ株式会社 Puncture device
JP3668382B2 (en) 1998-11-19 2005-07-06 テルモ株式会社 Component measuring device
EP2230513B1 (en) 1998-11-30 2016-04-13 Abbott Laboratories Multichemistry measuring device
US6285454B1 (en) 1998-12-07 2001-09-04 Mercury Diagnostics, Inc. Optics alignment and calibration system
DE69939598D1 (en) 1999-01-04 2008-10-30 Terumo Corp Landzettenanordnung for removing and evidence of body fluids
US6210420B1 (en) * 1999-01-19 2001-04-03 Agilent Technologies, Inc. Apparatus and method for efficient blood sampling with lancet
DE60045351D1 (en) 1999-02-04 2011-01-20 Integ Inc Needle body fluid tester
US6045567A (en) 1999-02-23 2000-04-04 Lifescan Inc. Lancing device causing reduced pain
US6964668B2 (en) 1999-03-04 2005-11-15 Abbott Laboratories Articulating suturing device and method
DE19909602A1 (en) 1999-03-05 2000-09-07 Roche Diagnostics Gmbh Device for withdrawing blood for diagnostic purposes
US7077828B2 (en) 1999-03-05 2006-07-18 Roche Diagnostics Gmbh Device for withdrawing blood for diagnostic applications
US6306152B1 (en) 1999-03-08 2001-10-23 Agilent Technologies, Inc. Lancet device with skin movement control and ballistic preload
US6132449A (en) * 1999-03-08 2000-10-17 Agilent Technologies, Inc. Extraction and transportation of blood for analysis
US6402701B1 (en) * 1999-03-23 2002-06-11 Fna Concepts, Llc Biopsy needle instrument
US6120462A (en) 1999-03-31 2000-09-19 Ethicon Endo-Surgery, Inc. Control method for an automated surgical biopsy device
US6231531B1 (en) * 1999-04-09 2001-05-15 Agilent Technologies, Inc. Apparatus and method for minimizing pain perception
US6152942A (en) 1999-06-14 2000-11-28 Bayer Corporation Vacuum assisted lancing device
EP1211979A1 (en) 1999-06-30 2002-06-12 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO Pricking device, carrier and cassette comprising a plurality of lancets
DE19945828B4 (en) * 1999-09-24 2011-06-01 Roche Diagnostics Gmbh Analytical element and method for determining an analyte in liquid
JP4359671B2 (en) 1999-09-29 2009-11-04 アークレイ株式会社 The body fluid sampling tool
DE19948759A1 (en) * 1999-10-09 2001-04-12 Roche Diagnostics Gmbh Blood lancet device for withdrawing blood for diagnostic purposes
JP4210782B2 (en) * 1999-10-13 2009-01-21 アークレイ株式会社 Blood collection position display device
US6283982B1 (en) 1999-10-19 2001-09-04 Facet Technologies, Inc. Lancing device and method of sample collection
US6228100B1 (en) * 1999-10-25 2001-05-08 Steven Schraga Multi-use lancet device
JP3985022B2 (en) 1999-11-08 2007-10-03 アークレイ株式会社 Body fluid measurement device, and inserted body to be used in inserted into the body fluid measuring apparatus
US6364889B1 (en) * 1999-11-17 2002-04-02 Bayer Corporation Electronic lancing device
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
CA2394171A1 (en) 1999-12-16 2001-06-21 Alza Corporation Device for enhancing transdermal flux of sampled agents
US6379969B1 (en) * 2000-03-02 2002-04-30 Agilent Technologies, Inc. Optical sensor for sensing multiple analytes
US6423011B1 (en) 2000-03-02 2002-07-23 Clinical Innovation Associates, Inc. Apparatus and method for fetal scalp blood sampling
US6375627B1 (en) * 2000-03-02 2002-04-23 Agilent Technologies, Inc. Physiological fluid extraction with rapid analysis
US6706159B2 (en) * 2000-03-02 2004-03-16 Diabetes Diagnostics Combined lancet and electrochemical analyte-testing apparatus
DE10010694A1 (en) 2000-03-04 2001-09-06 Roche Diagnostics Gmbh Lancet including tipped needle with body surrounding tip
US6612111B1 (en) 2000-03-27 2003-09-02 Lifescan, Inc. Method and device for sampling and analyzing interstitial fluid and whole blood samples
US6613064B2 (en) 2000-04-04 2003-09-02 P.Z. “Htl” S.A. Arrangement regulating depth of the puncture, used in the device for puncturing
US6402704B1 (en) * 2000-04-18 2002-06-11 Sonexxus Incorporated Prothrombin test apparatus for home use
JP2001321368A (en) 2000-05-16 2001-11-20 Fuji Photo Film Co Ltd Plasma taking tool
DE10026172A1 (en) * 2000-05-26 2001-11-29 Roche Diagnostics Gmbh System for withdrawing body fluid
DE10030410C1 (en) 2000-06-21 2002-01-24 Roche Diagnostics Gmbh Blood lancet device for withdrawing blood for diagnostic purposes
DE10029453C2 (en) * 2000-06-21 2002-06-13 Roche Diagnostics Gmbh Pump for very low flow rates
US6561989B2 (en) 2000-07-10 2003-05-13 Bayer Healthcare, Llc Thin lance and test sensor having same
GB0017737D0 (en) 2000-07-20 2000-09-06 Hypoguard Limited Test device
US6451040B1 (en) 2000-09-01 2002-09-17 Bayer Corporation Adjustable endcap for lancing device
US6423014B1 (en) 2000-09-29 2002-07-23 University Of Vermont Therapeutic and diagnostic needling device and method
EP1203563A3 (en) * 2000-10-31 2004-01-02 Boehringer Mannheim Gmbh Analyzing mean with integrated lancet
WO2002064193A3 (en) * 2000-12-14 2003-01-16 Georgia Tech Res Inst Microneedle devices and production thereof
US6491709B2 (en) 2000-12-22 2002-12-10 Becton, Dickinson And Company Alternate-site lancer
CN101366633B (en) 2001-01-19 2011-03-30 松下电器产业株式会社 Lancet-integrated sensor, measuring device for lancet-integrated sensor, and cartridge
WO2002056751A3 (en) * 2001-01-22 2002-11-07 Roche Diagnostics Corp Lancet device having capillary action
US6530892B1 (en) 2001-03-07 2003-03-11 Helen V. Kelly Automatic skin puncturing system
US6752817B2 (en) * 2001-03-26 2004-06-22 Bayer Corporation Split pressure ring for lancing device and method of operation
KR100893275B1 (en) 2001-03-29 2009-04-17 라이프스캔 스코트랜드 리미티드 Integrated sample testing meter
US6783502B2 (en) 2001-04-26 2004-08-31 Phoenix Bioscience Integrated lancing and analytic device
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7316700B2 (en) 2001-06-12 2008-01-08 Pelikan Technologies, Inc. Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
US7244265B2 (en) 2002-04-19 2007-07-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
WO2002100460A3 (en) 2001-06-12 2003-05-08 Don Alden Electric lancet actuator
US7041068B2 (en) * 2001-06-12 2006-05-09 Pelikan Technologies, Inc. Sampling module device and method
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7410468B2 (en) 2002-04-19 2008-08-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7226461B2 (en) 2002-04-19 2007-06-05 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
EP1501410B1 (en) 2002-04-19 2016-06-08 Sanofi-Aventis Deutschland GmbH Apparatus for penetrating tissue
US7648468B2 (en) 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
WO2002100253A3 (en) 2001-06-12 2003-07-17 Vladimir Drbal Blood sampling device with diaphragm actuated lancet
US7563232B2 (en) 2002-04-19 2009-07-21 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7344507B2 (en) 2002-04-19 2008-03-18 Pelikan Technologies, Inc. Method and apparatus for lancet actuation
US7481776B2 (en) 2002-04-19 2009-01-27 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7374544B2 (en) 2002-04-19 2008-05-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US6939310B2 (en) 2001-10-10 2005-09-06 Lifescan, Inc. Devices for physiological fluid sampling and methods of using the same
US6945943B2 (en) 2002-05-01 2005-09-20 Lifescan, Inc. Analyte concentration determination devices and methods of using the same
JP6004150B1 (en) 2015-03-24 2016-10-05 日立金属株式会社 Ceramic honeycomb structure and a manufacturing method thereof

Cited By (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7744537B2 (en) * 2001-08-20 2010-06-29 Japan Science And Technology Agency Ultrasonic method and system for characterizing arterial tissue using known elasticity data
US20040260180A1 (en) * 2001-08-20 2004-12-23 Hiroshi Kanai Tissue identifying method in ultrasonography and ultrasonograph
US20060161077A1 (en) * 2003-06-23 2006-07-20 Masao Takinami Body fluid sampling implement and body fluid sampling method
US20050234368A1 (en) * 2004-04-15 2005-10-20 Daniel Wong Integrated spot monitoring device with fluid sensor
US20060100542A9 (en) * 2004-04-15 2006-05-11 Daniel Wong Integrated spot monitoring device with fluid sensor
US8187205B2 (en) 2004-04-15 2012-05-29 Roche Diagnostics Operations, Inc. Integrated spot monitoring device with fluid sensor
US8747335B2 (en) 2004-04-15 2014-06-10 Roche Diagnostics Operations, Inc. Integrated spot monitoring device with fluid sensor
US7351213B2 (en) 2004-04-15 2008-04-01 Roche Diagnostics Operation, Inc. Integrated spot monitoring device with fluid sensor
US20080161725A1 (en) * 2004-04-15 2008-07-03 Daniel Wong Integrated spot monitoring device with fluid sensor
US20090299226A1 (en) * 2004-04-15 2009-12-03 Daniel Wong Integrated spot monitoring device with fluid sensor
US7654969B2 (en) 2004-04-15 2010-02-02 Roche Diagnostics Operations, Inc. Integrated spot monitoring device with fluid sensor
US20090312669A1 (en) * 2004-10-27 2009-12-17 Abbott Laboratories Blood Expression Device
US8177730B2 (en) * 2004-10-27 2012-05-15 Abbott Laboratories Blood expression device
US20070112367A1 (en) * 2005-11-17 2007-05-17 Olson Lorin P Method for lancing a dermal tissue target site using a cap with revolving body
US20070112281A1 (en) * 2005-11-17 2007-05-17 Olson Lorin P Cap with revolving body for a dermal tissue lancing device
US7914547B2 (en) 2006-06-15 2011-03-29 Abbott Diabetes Care Inc. Adjustable lancing devices and methods
US20080027474A1 (en) * 2006-06-15 2008-01-31 Abbott Diabetes Care Inc. Adjustable Lancing Devices and Methods
US20100286467A1 (en) * 2007-03-19 2010-11-11 Benny Pesach Device for drug delivery and associated connections thereto
US9220837B2 (en) 2007-03-19 2015-12-29 Insuline Medical Ltd. Method and device for drug delivery
US20100113981A1 (en) * 2008-05-09 2010-05-06 Panasonic Corporation Skin incision instrument and method for incising skin with the same
US7833173B2 (en) 2008-05-13 2010-11-16 Panasonic Corporation Skin incision instrument and method for incising skin with the same
US8097013B2 (en) 2008-05-13 2012-01-17 Panasonic Corporation Skin incision instrument and method for incising skin with the same
US20100268259A1 (en) * 2008-05-13 2010-10-21 Panasonic Corporation Skin incision instrument and method for incising skin with the same
US8123772B2 (en) 2008-08-14 2012-02-28 Abbott Diabetes Care Inc. Cap for lancing device with adjustable mode of operation
US8092476B2 (en) 2008-08-14 2012-01-10 Abbott Diabetes Care Inc. Adjustable cap and lancing device and method of use
US20100042129A1 (en) * 2008-08-14 2010-02-18 Abbott Diabetes Care Inc. Adjustable cap and lancing device and method of use
US20100042128A1 (en) * 2008-08-14 2010-02-18 Abbott Diabetes Care Inc. Cap for lancing device with adjustable mode of operation
EP2647337B1 (en) * 2009-11-09 2015-10-14 Owen Mumford Limited Skin stimulus
US20120245497A1 (en) * 2009-11-09 2012-09-27 Owen Mumford Limited Skin stimulus
EP2647337A2 (en) * 2009-11-09 2013-10-09 Owen Mumford Limited Skin stimulus
US9724034B2 (en) * 2009-11-09 2017-08-08 Owen Mumford Limited Skin stimulus
US20120065487A1 (en) * 2010-09-07 2012-03-15 Innova Medical Design LLC Systems, methods, and devices for reducing the pain of glucose monitoring and insulin adminstration in diabetic patients

Also Published As

Publication number Publication date Type
US20120289864A1 (en) 2012-11-15 application
US20040073140A1 (en) 2004-04-15 application
US8740813B2 (en) 2014-06-03 grant
US20110046515A1 (en) 2011-02-24 application
US7841991B2 (en) 2010-11-30 grant

Similar Documents

Publication Publication Date Title
US6306152B1 (en) Lancet device with skin movement control and ballistic preload
US4919146A (en) Biopsy device
US6071294A (en) Lancet cartridge for sampling blood
US7288102B2 (en) Lancing device with decoupled lancet
US7749174B2 (en) Method and apparatus for lancet launching device intergrated onto a blood-sampling cartridge
US7244266B2 (en) System for pain-reduced withdrawal of blood
US6391005B1 (en) Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US20080097503A1 (en) Damping System for a Lancet Using Compressed Air
US6283982B1 (en) Lancing device and method of sample collection
EP1157660B1 (en) System for withdrawing body fluid
US5871494A (en) Reproducible lancing for sampling blood
US20040260326A1 (en) Lancing device with floating lancet
US20040267229A1 (en) In-situ adapter for a testing device
US20060184189A1 (en) Cap for a dermal tissue lancing device
US4883068A (en) Blood sampling device and method
EP1643908B1 (en) System for withdrawing body fluid
US20050245954A1 (en) Lancets for bodily fluid sampling supplied on a tape
US20040254599A1 (en) Method and apparatus for pre-lancing stimulation of puncture site
US6027459A (en) Method and apparatus for obtaining blood for diagnostic tests
US20040116829A1 (en) Sampling devices and methods utilizing a horizontal capillary test strip
US20080009767A1 (en) System for withdrawing small amounts of body fluid
US20050070819A1 (en) Body fluid sampling constructions and techniques
US20060287664A1 (en) Endcap for a fluid sampling device
US5680872A (en) Simple blood-collecting device
US7378007B2 (en) Combined lancet and electrochemical analyte-testing apparatus

Legal Events

Date Code Title Description
AS Assignment

Owner name: AMIRA MEDICAL, CALIFORNIA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:DOUGLAS, JOEL S.;ROE, JEFFREY N.;REEL/FRAME:012620/0311

Effective date: 20011203

AS Assignment

Owner name: ROCHE DIAGNOSTICS OPERATIONS, INC., INDIANA

Free format text: CHANGE OF NAME;ASSIGNOR:AMIRA MEDICAL;REEL/FRAME:015072/0514

Effective date: 20031010

AS Assignment

Owner name: ROCHE DIABETES CARE, INC., INDIANA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:ROCHE DIAGNOSTICS OPERATIONS, INC.;REEL/FRAME:036008/0670

Effective date: 20150302