DE69700499T2 - Vorrichtung und verfahren zum nachweis mehrerer analyten - Google Patents

Vorrichtung und verfahren zum nachweis mehrerer analyten

Info

Publication number
DE69700499T2
DE69700499T2 DE69700499T DE69700499T DE69700499T2 DE 69700499 T2 DE69700499 T2 DE 69700499T2 DE 69700499 T DE69700499 T DE 69700499T DE 69700499 T DE69700499 T DE 69700499T DE 69700499 T2 DE69700499 T2 DE 69700499T2
Authority
DE
Germany
Prior art keywords
detecting several
several analyzes
analyzes
detecting
several
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69700499T
Other languages
English (en)
Other versions
DE69700499D1 (de
Inventor
Timothy Woudenberg
Michael Albin
Reid Kowallis
Yefim Raysberg
Robert Ragusa
Emily Winn-Deen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Biosystems LLC
Original Assignee
Perkin Elmer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perkin Elmer Corp filed Critical Perkin Elmer Corp
Publication of DE69700499D1 publication Critical patent/DE69700499D1/de
Application granted granted Critical
Publication of DE69700499T2 publication Critical patent/DE69700499T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302—Apparatus specially adapted for immunological test procedures
    • G01N33/5304—Reaction vessels, e.g. agglutination plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/06—Quantitative determination
    • C12Q1/08—Quantitative determination using multifield media
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0642—Filling fluids into wells by specific techniques
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/141—Preventing contamination, tampering
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1827—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using resistive heater
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00148—Test cards, e.g. Biomerieux or McDonnel multiwell test cards
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/973—Simultaneous determination of more than one analyte
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Clinical Laboratory Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69700499T 1996-04-03 1997-04-02 Vorrichtung und verfahren zum nachweis mehrerer analyten Expired - Lifetime DE69700499T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1471296P 1996-04-03 1996-04-03
PCT/US1997/005458 WO1997036681A1 (en) 1996-04-03 1997-04-02 Device and method for multiple analyte detection

Publications (2)

Publication Number Publication Date
DE69700499D1 DE69700499D1 (de) 1999-10-14
DE69700499T2 true DE69700499T2 (de) 2000-03-23

Family

ID=21767215

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69700499T Expired - Lifetime DE69700499T2 (de) 1996-04-03 1997-04-02 Vorrichtung und verfahren zum nachweis mehrerer analyten

Country Status (7)

Country Link
US (2) US6126899A (de)
EP (1) EP0889751B1 (de)
JP (3) JP4912517B2 (de)
AU (1) AU706862B2 (de)
CA (1) CA2250212C (de)
DE (1) DE69700499T2 (de)
WO (1) WO1997036681A1 (de)

Families Citing this family (277)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7560273B2 (en) 2002-07-23 2009-07-14 Applied Biosystems, Llc Slip cover for heated platen assembly
US7244622B2 (en) * 1996-04-03 2007-07-17 Applera Corporation Device and method for multiple analyte detection
US6825047B1 (en) * 1996-04-03 2004-11-30 Applera Corporation Device and method for multiple analyte detection
US7235406B1 (en) * 1996-04-03 2007-06-26 Applera Corporation Nucleic acid analysis device
CN1329729C (zh) 1996-06-28 2007-08-01 卡钳生命科学股份有限公司 微流体系统
US5779868A (en) * 1996-06-28 1998-07-14 Caliper Technologies Corporation Electropipettor and compensation means for electrophoretic bias
FR2762092B1 (fr) * 1997-04-15 1999-05-28 Bio Merieux Procede et dispositif de remplissage avec un milieu liquide d'une carte d'analyse
US6143496A (en) 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
US7033474B1 (en) * 1997-04-25 2006-04-25 Caliper Life Sciences, Inc. Microfluidic devices incorporating improved channel geometries
US6300138B1 (en) * 1997-08-01 2001-10-09 Qualigen, Inc. Methods for conducting tests
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
DE69925726D1 (de) * 1998-05-13 2005-07-14 Bayer Ag Gerät zum einführen einer probe
WO1999060397A1 (en) 1998-05-18 1999-11-25 University Of Washington Liquid analysis cartridge
US6830729B1 (en) 1998-05-18 2004-12-14 University Of Washington Sample analysis instrument
US6761816B1 (en) 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
US6576478B1 (en) 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6897073B2 (en) 1998-07-14 2005-05-24 Zyomyx, Inc. Non-specific binding resistant protein arrays and methods for making the same
US6682942B1 (en) 1998-07-14 2004-01-27 Zyomyx, Inc. Microdevices for screening biomolecules
FR2790684B1 (fr) 1999-03-09 2001-05-11 Biomerieux Sa Appareil permettant en son sein le transfert de liquides par capillarite
FR2790686B3 (fr) * 1999-03-09 2001-05-11 Biomerieux Sa Carte d'analyse dont le remplissage est associe a au moins un volume tampon
FR2790685B1 (fr) * 1999-03-09 2001-05-11 Biomerieux Sa Carte d'analyse dont le remplissage est associe a au moins un volume tampon
US6942771B1 (en) * 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
US7157056B2 (en) 1999-05-12 2007-01-02 Bayer Corporation Sample introduction device
AU768113B2 (en) * 1999-07-02 2003-12-04 Clondiag Chip Technologies Gmbh Microchip matrix device for duplicating and characterizing nucleic acids
DE19931901A1 (de) * 1999-07-08 2001-01-11 Basf Ag Verfahren und Vorrichtung zum Parallel-Analysieren von kolloidalen Teilchen mit Feldflußfraktionierung
WO2001006253A2 (en) * 1999-07-16 2001-01-25 Board Of Regents, The University Of Texas System Detection system based on an analyte reactive particle
US6660147B1 (en) * 1999-07-16 2003-12-09 Applera Corporation High density electrophoresis device and method
FR2796571B1 (fr) * 1999-07-19 2001-09-14 Bio Merieux Dispositif d'analyse avec une biopuce
US7267457B2 (en) * 1999-09-24 2007-09-11 Cao Group, Inc. Method for detecting forensic evidence
US6954270B2 (en) * 2002-12-20 2005-10-11 Cao Group, Inc. Method for detecting forensic evidence
ATE237399T1 (de) 1999-09-29 2003-05-15 Tecan Trading Ag Thermocycler sowie hebeelement für mikrotiterplatte
GB9922971D0 (en) 1999-09-29 1999-12-01 Secr Defence Reaction system
EP1369699A1 (de) * 1999-10-15 2003-12-10 PE Corporation (NY) System und Verfahren zum füllen eines Substrats mit einer flüssigen Probe
US6272939B1 (en) * 1999-10-15 2001-08-14 Applera Corporation System and method for filling a substrate with a liquid sample
US7260248B2 (en) * 1999-12-15 2007-08-21 Medispectra, Inc. Image processing using measures of similarity
US7169355B1 (en) 2000-02-02 2007-01-30 Applera Corporation Apparatus and method for ejecting sample well trays
US6690467B1 (en) 2000-05-05 2004-02-10 Pe Corporation Optical system and method for optically analyzing light from a sample
US7575915B2 (en) * 2000-05-26 2009-08-18 Panasonic Corporation Biosensor
US6540675B2 (en) 2000-06-27 2003-04-01 Rosedale Medical, Inc. Analyte monitor
US6719949B1 (en) 2000-06-29 2004-04-13 Applera Corporation Apparatus and method for transporting sample well trays
US6563581B1 (en) 2000-07-14 2003-05-13 Applera Corporation Scanning system and method for scanning a plurality of samples
FR2812306B1 (fr) * 2000-07-28 2005-01-14 Gabriel Festoc Systeme d'amplification en chaine par polymerse de sequences nucleiques cibles
US7216660B2 (en) * 2000-11-02 2007-05-15 Princeton University Method and device for controlling liquid flow on the surface of a microfluidic chip
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US6770434B2 (en) * 2000-12-29 2004-08-03 The Provost, Fellows And Scholars Of The College Of The Holy & Undivided Trinity Of Queen Elizabeth Near Dublin Biological assay method
CN1500140A (zh) * 2001-03-28 2004-05-26 上海晶泰生物技术有限公司 用于测试多种待分析物的装置及方法
GB0110476D0 (en) 2001-04-30 2001-06-20 Secr Defence Reagent delivery system
US20020168292A1 (en) * 2001-05-14 2002-11-14 Whisenhunt Donald Wayne Systems and methods for the high throughput preparation and analysis of chemical reactions
DE60238119D1 (de) 2001-06-12 2010-12-09 Pelikan Technologies Inc Elektrisches betätigungselement für eine lanzette
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
EP1404235A4 (de) 2001-06-12 2008-08-20 Pelikan Technologies Inc Verfahren und gerät für eine auf einer blutentnahmekartusche integrierte lanzettenvorrichtung
US7025774B2 (en) 2001-06-12 2006-04-11 Pelikan Technologies, Inc. Tissue penetration device
US7316700B2 (en) 2001-06-12 2008-01-08 Pelikan Technologies, Inc. Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US6514750B2 (en) * 2001-07-03 2003-02-04 Pe Corporation (Ny) PCR sample handling device
US6682702B2 (en) * 2001-08-24 2004-01-27 Agilent Technologies, Inc. Apparatus and method for simultaneously conducting multiple chemical reactions
US20030049850A1 (en) * 2001-09-12 2003-03-13 Golden Josh H. Enhanced detection of metal plating additives
US6744502B2 (en) 2001-09-28 2004-06-01 Pe Corporation (Ny) Shaped illumination geometry and intensity using a diffractive optical element
US20030138819A1 (en) * 2001-10-26 2003-07-24 Haiqing Gong Method for detecting disease
US7338760B2 (en) 2001-10-26 2008-03-04 Ntu Ventures Private Limited Sample preparation integrated chip
US7118910B2 (en) 2001-11-30 2006-10-10 Fluidigm Corporation Microfluidic device and methods of using same
US7691333B2 (en) 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
US6677151B2 (en) 2002-01-30 2004-01-13 Applera Corporation Device and method for thermal cycling
US7004928B2 (en) 2002-02-08 2006-02-28 Rosedale Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7226461B2 (en) 2002-04-19 2007-06-05 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7175642B2 (en) 2002-04-19 2007-02-13 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8372016B2 (en) 2002-04-19 2013-02-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling and analyte sensing
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US20030207441A1 (en) * 2002-05-01 2003-11-06 Eyster Curt R. Devices and methods for analyte concentration determination
US9157860B2 (en) 2002-05-16 2015-10-13 Applied Biosystems, Llc Achromatic lens array
US6982166B2 (en) 2002-05-16 2006-01-03 Applera Corporation Lens assembly for biological testing
US7560239B2 (en) * 2002-06-04 2009-07-14 Lin-Zhi International Inc. Homogeneous enzyme immunoassay for simultaneous detection of multiple analytes
US7459696B2 (en) * 2003-04-18 2008-12-02 Schomacker Kevin T Methods and apparatus for calibrating spectral data
US7083974B2 (en) 2002-07-12 2006-08-01 Applera Corporation Rotatable sample disk and method of loading a sample disk
US7452712B2 (en) * 2002-07-30 2008-11-18 Applied Biosystems Inc. Sample block apparatus and method of maintaining a microcard on a sample block
US7810380B2 (en) 2003-03-25 2010-10-12 Tearlab Research, Inc. Systems and methods for collecting tear film and measuring tear film osmolarity
CN1675532B (zh) * 2002-08-06 2010-05-26 加利福尼亚大学董事会 泪膜渗透压测定法
US7905134B2 (en) 2002-08-06 2011-03-15 The Regents Of The University Of California Biomarker normalization
US7534601B2 (en) * 2002-08-27 2009-05-19 Vanderbilt University Capillary perfused bioreactors with multiple chambers
US7790443B2 (en) * 2002-08-27 2010-09-07 Vanderbilt University Bioreactors with substance injection capacity
AU2003262906A1 (en) * 2002-08-27 2004-03-19 Vanderbilt University Bioreactors with multiple chambers
DE10245435B4 (de) * 2002-09-27 2006-03-16 Micronas Gmbh Vorrichtung zur Detektion mindestens eines in einer zu untersuchenden Probe enthaltenen Liganden
US7932098B2 (en) * 2002-10-31 2011-04-26 Hewlett-Packard Development Company, L.P. Microfluidic system utilizing thin-film layers to route fluid
KR100858080B1 (ko) * 2002-11-12 2008-09-10 삼성전자주식회사 전기적 신호를 측정하는 ｐｃｒ 증폭 산물을 검출하는 방법
JP2006508662A (ja) 2002-12-04 2006-03-16 アプレラ コーポレイション ポリヌクレオチドの多重増幅
WO2004052541A1 (en) * 2002-12-11 2004-06-24 Inverness Medical Switzerland Gmbh Micro-fluidic structure, method and apparatus for its production, and use thereof
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US7338637B2 (en) * 2003-01-31 2008-03-04 Hewlett-Packard Development Company, L.P. Microfluidic device with thin-film electronic devices
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
EP1606419A1 (de) 2003-03-18 2005-12-21 Quantum Genetics Ireland Limited Systeme und methoden zur erhohung der milchproduktion in tieren
US7052652B2 (en) 2003-03-24 2006-05-30 Rosedale Medical, Inc. Analyte concentration detection devices and methods
US7476363B2 (en) 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
US8828663B2 (en) 2005-03-18 2014-09-09 Fluidigm Corporation Thermal reaction device and method for using the same
EP1615721B1 (de) 2003-04-03 2014-06-18 Fluidigm Corporation Mikrofluidvorrichtungen und verwendungsverfahren dafür
US20050145496A1 (en) 2003-04-03 2005-07-07 Federico Goodsaid Thermal reaction device and method for using the same
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
WO2004105947A2 (en) * 2003-05-23 2004-12-09 Bio-Rad Laboratories, Inc. Localized temperature control for spatial arrays of reaction media
DE602004028463D1 (de) 2003-05-30 2010-09-16 Pelikan Technologies Inc Verfahren und vorrichtung zur injektion von flüssigkeit
US7850621B2 (en) 2003-06-06 2010-12-14 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
AU2003241850A1 (en) * 2003-06-07 2005-01-04 Genomictree Inc. Multi-hybridization set for dna microarray related assay
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
US20040258563A1 (en) 2003-06-23 2004-12-23 Applera Corporation Caps for sample wells and microcards for biological materials
US6883851B2 (en) * 2003-09-16 2005-04-26 Honda Motor Company, Ltd. Cargo carrying system having multiple closure members
US7570443B2 (en) 2003-09-19 2009-08-04 Applied Biosystems, Llc Optical camera alignment
US20050232818A1 (en) * 2003-09-19 2005-10-20 Donald Sandell Single sheet seal applicator and cartridge
US9492820B2 (en) 2003-09-19 2016-11-15 Applied Biosystems, Llc High density plate filler
US20060029948A1 (en) * 2003-09-19 2006-02-09 Gary Lim Sealing cover and dye compatibility selection
US7998435B2 (en) 2003-09-19 2011-08-16 Life Technologies Corporation High density plate filler
US20060013984A1 (en) * 2003-09-19 2006-01-19 Donald Sandell Film preparation for seal applicator
US7695688B2 (en) * 2003-09-19 2010-04-13 Applied Biosystems, Llc High density plate filler
EP1670945A2 (de) * 2003-09-19 2006-06-21 Applera Corporation Zur ausführung einer nukleotidamplifikation mit temperaturzyklus geeignete mikroplatten
US20050226780A1 (en) * 2003-09-19 2005-10-13 Donald Sandell Manual seal applicator
US8277760B2 (en) 2003-09-19 2012-10-02 Applied Biosystems, Llc High density plate filler
US20070014694A1 (en) * 2003-09-19 2007-01-18 Beard Nigel P High density plate filler
US20060011305A1 (en) * 2003-09-19 2006-01-19 Donald Sandell Automated seal applicator
US20050232821A1 (en) * 2003-09-19 2005-10-20 Carrillo Albert L High density plate filler
US7407630B2 (en) 2003-09-19 2008-08-05 Applera Corporation High density plate filler
EP1671096A4 (de) 2003-09-29 2009-09-16 Pelikan Technologies Inc Verfahren und apparatur für eine verbesserte probeneinfangvorrichtung
WO2005037095A1 (en) 2003-10-14 2005-04-28 Pelikan Technologies, Inc. Method and apparatus for a variable user interface
WO2005059086A1 (en) * 2003-12-16 2005-06-30 Canon Kabushiki Kaisha Biologically active substance transfer sheet, cell culture kit constituted of cell culture plate and biologically active substance transfer sheet, producing method thereof and method for screening cell culture conditions utilizing the same
EP1706026B1 (de) 2003-12-31 2017-03-01 Sanofi-Aventis Deutschland GmbH Verfahren und vorrichtung zur verbesserung der fluidströmung und der probennahme
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
EP1703981A1 (de) * 2004-01-12 2006-09-27 Applera Corporation Verfahren und vorrichtung zum nachweis von nucleinsäuresequenzen
US20050164373A1 (en) * 2004-01-22 2005-07-28 Oldham Mark F. Diffusion-aided loading system for microfluidic devices
JP2007525217A (ja) 2004-02-19 2007-09-06 ザ ガバナーズ オブ ザ ユニバーシティー オブ アルバータ レプチンプロモーター多型及びその使用
US20050255485A1 (en) * 2004-05-14 2005-11-17 Livak Kenneth J Detection of gene duplications
US8828203B2 (en) 2004-05-20 2014-09-09 Sanofi-Aventis Deutschland Gmbh Printable hydrogels for biosensors
WO2005120365A1 (en) 2004-06-03 2005-12-22 Pelikan Technologies, Inc. Method and apparatus for a fluid sampling device
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
US8563328B2 (en) * 2004-07-26 2013-10-22 University Of Louisville Research Foundation, Inc. Fiber-optic biosensor and biosensing methods
FR2874385B1 (fr) * 2004-08-18 2006-12-08 Biopep Sa Procede et dispositif de mesure d'une activite enzymatique dans un fluide biologique
US20110038758A1 (en) * 2004-11-22 2011-02-17 Nissui Pharmaceutical Co., Ltd. Microchip
US8084260B2 (en) * 2004-11-24 2011-12-27 Applied Biosystems, Llc Spectral calibration method and system for multiple instruments
US8695355B2 (en) * 2004-12-08 2014-04-15 California Institute Of Technology Thermal management techniques, apparatus and methods for use in microfluidic devices
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
JP2006223126A (ja) * 2005-02-15 2006-08-31 Shimadzu Corp 反応容器、遺伝子多型検出方法及び装置、並びに診断方法及び装置
WO2006088976A2 (en) * 2005-02-16 2006-08-24 University Of Louisville Research Foundation, Inc. Fiber-optic biosensor and biosensing methods
US8008066B2 (en) 2005-03-10 2011-08-30 Gen-Probe Incorporated System for performing multi-formatted assays
EP1707267A1 (de) * 2005-03-30 2006-10-04 F. Hoffman-la Roche AG Vorrichtung mit selbstdichtendem EInlass
US20060246493A1 (en) 2005-04-04 2006-11-02 Caliper Life Sciences, Inc. Method and apparatus for use in temperature controlled processing of microfluidic samples
WO2006116455A2 (en) * 2005-04-26 2006-11-02 Applera Corporation System for genetic surveillance and analysis
US20070014695A1 (en) * 2005-04-26 2007-01-18 Applera Corporation Systems and Methods for Multiple Analyte Detection
US20060281187A1 (en) 2005-06-13 2006-12-14 Rosedale Medical, Inc. Analyte detection devices and methods with hematocrit/volume correction and feedback control
JP2009500609A (ja) * 2005-06-30 2009-01-08 アプレラ コーポレーション 導電性ポリマーを含む多孔質コンポジット電極
US20070175768A1 (en) * 2005-06-30 2007-08-02 Applera Corporation Microfluidic systems including porous polymer electrodes
US8801631B2 (en) 2005-09-30 2014-08-12 Intuity Medical, Inc. Devices and methods for facilitating fluid transport
EP3461406A1 (de) 2005-09-30 2019-04-03 Intuity Medical, Inc. Kassette zur entnahme und analyse von körperflüssigkeiten mit mehreren stellen
WO2007044974A2 (en) * 2005-10-12 2007-04-19 The Research Foundation Of State University Of New York Absolute pcr quantification
EP1954197A2 (de) * 2005-11-22 2008-08-13 Stichting Top Institute Food and Nutrition Vorrichtung zur entnahme von flüssigkeitsproben in vivo aus dem gastrointestinaltrakt, verfahren zu ihrer herstellung und form oder maske zur verwendung im herstellungsverfahren
US8900828B2 (en) 2006-05-01 2014-12-02 Cepheid Methods and apparatus for sequential amplification reactions
US20070280857A1 (en) * 2006-06-02 2007-12-06 Applera Corporation Devices and Methods for Positioning Dried Reagent In Microfluidic Devices
US7759062B2 (en) * 2006-06-09 2010-07-20 Third Wave Technologies, Inc. T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection
EP2040983A4 (de) * 2006-06-26 2011-08-03 Life Technologies Corp Komprimierbare transparente dichtung für offene mikroplatten
CA2665188C (en) 2006-10-04 2014-08-19 Third Wave Technologies, Inc. Snap-back primers and detectable hairpin structures
US20080245740A1 (en) * 2007-01-29 2008-10-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Fluidic methods
JP5012817B2 (ja) * 2007-02-05 2012-08-29 株式会社島津製作所 反応容器プレート及び反応処理方法
CN101675170B (zh) * 2007-03-02 2013-09-18 考贝特研究控股公司 用于核酸扩增的装置和方法
US9458451B2 (en) * 2007-06-21 2016-10-04 Gen-Probe Incorporated Multi-channel optical measurement instrument
JP2009042103A (ja) * 2007-08-09 2009-02-26 Sony Corp 基板、これを用いた反応処理装置並びに反応制御方法
US20090055243A1 (en) 2007-08-21 2009-02-26 Jayson Lee Lusk Systems and methods for predicting a livestock marketing method
US20090081768A1 (en) * 2007-09-21 2009-03-26 Applera Corporation Devices and Methods for Thermally Isolating Chambers of an Assay Card
JP5251882B2 (ja) * 2007-10-26 2013-07-31 凸版印刷株式会社 反応チップ及び反応方法、遺伝子処理装置用温度調節機構及び遺伝子処理装置
CA2705213C (en) * 2007-11-07 2016-10-04 The University Of British Columbia Microfluidic device and method of using same
JP5441142B2 (ja) * 2007-11-26 2014-03-12 国立大学法人 東京大学 マイクロ流体による平面脂質二重膜アレイ及びその平面脂質二重膜を用いた分析方法
KR101362905B1 (ko) * 2007-11-30 2014-02-19 (주)바이오니아 마이크로 챔버 플레이트, 그 제조방법
JP2011506998A (ja) * 2007-12-17 2011-03-03 ハイ−チング ゴング マイクロ流体デバイス
JP4556194B2 (ja) * 2008-02-01 2010-10-06 セイコーエプソン株式会社 生体試料反応方法
KR100969667B1 (ko) * 2008-03-24 2010-07-14 디지탈 지노믹스(주) 생리활성물질을 전기적으로 검출하는 방법 및 이를 위한바이오칩
US8834797B2 (en) 2008-04-04 2014-09-16 Life Technologies Corporation Scanning system and method for imaging and sequencing
EP2265324B1 (de) 2008-04-11 2015-01-28 Sanofi-Aventis Deutschland GmbH Integriertes System zur Messung von Analyten
JP5816080B2 (ja) 2008-05-30 2015-11-17 インテュイティ メディカル インコーポレイテッド 体液採取装置及び採取部位インターフェイス
EP2299904B1 (de) 2008-06-06 2019-09-11 Intuity Medical, Inc. Medizinisches messverfahren
JP5642066B2 (ja) 2008-06-06 2014-12-17 インテュイティ メディカル インコーポレイテッド 体液の試料内に含まれている検体の存在または濃度を決定する検定を行う方法および装置
US9180453B2 (en) * 2008-08-15 2015-11-10 University Of Washington Method and apparatus for the discretization and manipulation of sample volumes
US20100055733A1 (en) * 2008-09-04 2010-03-04 Lutolf Matthias P Manufacture and uses of reactive microcontact printing of biomolecules on soft hydrogels
US20230372935A1 (en) * 2008-09-23 2023-11-23 Bio-Rad Laboratories, Inc. Partition-based method of analysis
US9399215B2 (en) 2012-04-13 2016-07-26 Bio-Rad Laboratories, Inc. Sample holder with a well having a wicking promoter
WO2011120020A1 (en) 2010-03-25 2011-09-29 Quantalife, Inc. Droplet transport system for detection
US8951939B2 (en) 2011-07-12 2015-02-10 Bio-Rad Laboratories, Inc. Digital assays with multiplexed detection of two or more targets in the same optical channel
US9417190B2 (en) 2008-09-23 2016-08-16 Bio-Rad Laboratories, Inc. Calibrations and controls for droplet-based assays
US9598725B2 (en) 2010-03-02 2017-03-21 Bio-Rad Laboratories, Inc. Emulsion chemistry for encapsulated droplets
US8633015B2 (en) 2008-09-23 2014-01-21 Bio-Rad Laboratories, Inc. Flow-based thermocycling system with thermoelectric cooler
US8709762B2 (en) 2010-03-02 2014-04-29 Bio-Rad Laboratories, Inc. System for hot-start amplification via a multiple emulsion
US10512910B2 (en) 2008-09-23 2019-12-24 Bio-Rad Laboratories, Inc. Droplet-based analysis method
US9492797B2 (en) 2008-09-23 2016-11-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US11130128B2 (en) 2008-09-23 2021-09-28 Bio-Rad Laboratories, Inc. Detection method for a target nucleic acid
US9132394B2 (en) 2008-09-23 2015-09-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US9764322B2 (en) 2008-09-23 2017-09-19 Bio-Rad Laboratories, Inc. System for generating droplets with pressure monitoring
US20100119454A1 (en) * 2008-11-03 2010-05-13 Ping Shen Use of the conserved Drosophila NPFR1 system for uncovering interacting genes and pathways important in nociception and stress response
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
WO2010101626A1 (en) 2009-03-02 2010-09-10 Seventh Sense Biosystems, Inc. Techniques and devices associated with blood sampling
KR101796906B1 (ko) * 2009-03-24 2017-11-10 유니버시티 오브 시카고 반응을 수행하기 위한 방법
US9447461B2 (en) 2009-03-24 2016-09-20 California Institute Of Technology Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes
US10196700B2 (en) 2009-03-24 2019-02-05 University Of Chicago Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes
JP5881936B2 (ja) * 2009-04-20 2016-03-09 ソニー株式会社 試料溶液導入キット及び試料溶液注入器
JP5198369B2 (ja) * 2009-06-19 2013-05-15 国立大学法人 東京大学 人工脂質二重膜を用いた電流計測装置
WO2011028539A1 (en) 2009-09-02 2011-03-10 Quantalife, Inc. System for mixing fluids by coalescence of multiple emulsions
EP2493535A2 (de) * 2009-10-30 2012-09-05 Seventh Sense Biosystems, Inc. Systeme und verfahren zur anwendung auf der haut und zur steuerung ihrer betätigung, freisetzung und/oder wahrnehmung
EP2506768B1 (de) 2009-11-30 2016-07-06 Intuity Medical, Inc. Vorrichtung und verfahren zur ausgabe eines kalibrierungsmaterials
WO2011094573A1 (en) 2010-01-28 2011-08-04 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
JP5218443B2 (ja) 2010-02-10 2013-06-26 ソニー株式会社 マイクロチップ及びマイクロチップの製造方法
CA2767182C (en) 2010-03-25 2020-03-24 Bio-Rad Laboratories, Inc. Droplet generation for droplet-based assays
EP2550351A4 (de) 2010-03-25 2014-07-09 Quantalife Inc Detektionssystem für assays auf tröpfchenbasis
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
WO2011163347A2 (en) 2010-06-23 2011-12-29 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
US10330667B2 (en) 2010-06-25 2019-06-25 Intuity Medical, Inc. Analyte monitoring methods and systems
JP2013538069A (ja) 2010-07-16 2013-10-10 セブンス センス バイオシステムズ，インコーポレーテッド 流体移動デバイスのための低圧環境
WO2012011074A2 (en) 2010-07-22 2012-01-26 Hach Company Lab-on-a-chip for alkalinity analysis
US20130158482A1 (en) 2010-07-26 2013-06-20 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
US9046507B2 (en) 2010-07-29 2015-06-02 Gen-Probe Incorporated Method, system and apparatus for incorporating capacitive proximity sensing in an automated fluid transfer procedure
WO2012021801A2 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
DE202011110979U1 (de) 2010-11-01 2017-12-04 Bio-Rad Laboratories, Inc. System zum Bilden von Emulsionen
EP2992827B1 (de) 2010-11-09 2017-04-19 Seventh Sense Biosystems, Inc. Systeme und schnittstellen zur blutabnahme
WO2012116308A1 (en) 2011-02-24 2012-08-30 Gen-Probe Incorporated Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector
CA2830443C (en) 2011-03-18 2021-11-16 Bio-Rad Laboratories, Inc. Multiplexed digital assays with combinatorial use of signals
CN103717749A (zh) 2011-04-25 2014-04-09 伯乐生命医学产品有限公司 用于核酸分析的方法和组合物
EP2701598A1 (de) 2011-04-29 2014-03-05 Seventh Sense Biosystems, Inc. Systeme und verfahren zur flüssigkeitsentnahme aus einer person
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
EP2701600B1 (de) 2011-04-29 2016-06-08 Seventh Sense Biosystems, Inc. Ausgabe und/oder aufnahme von flüssigkeiten
AU2012249683A1 (en) 2011-04-29 2013-11-14 Seventh Sense Biosystems, Inc. Devices and methods for collection and/or manipulation of blood spots or other bodily fluids
EP2737089B1 (de) 2011-07-29 2017-09-06 Bio-rad Laboratories, Inc. Bibliothekscharakterisierung durch digitalen test
CA2843945C (en) 2011-08-03 2022-06-21 Intuity Medical, Inc. Devices and methods for body fluid sampling and analysis
EP2756101B1 (de) 2011-09-15 2018-05-23 David A. Shafer Probe: antiprobe-zusammensetzungen zum nachweis hochspezifischer dna oder rna
US9709469B2 (en) * 2011-11-11 2017-07-18 The Regents Of The University Of California Valveless microfluidic device
EP2785460B1 (de) * 2011-11-29 2021-01-27 Caliper Life Sciences, Inc. Systeme und verfahren zur probenanalyse von amplifikationsprodukten
US9689029B2 (en) 2011-12-02 2017-06-27 Caliper Life Sciences, Inc. Systems and methods for sampling of amplification products
US9063121B2 (en) 2012-05-09 2015-06-23 Stat-Diagnostica & Innovation, S.L. Plurality of reaction chambers in a test cartridge
US9180449B2 (en) 2012-06-12 2015-11-10 Hach Company Mobile water analysis
WO2014058064A1 (ja) * 2012-10-12 2014-04-17 学校法人日本大学 検査システム及び検査方法
CN103852576B (zh) * 2012-12-03 2017-11-28 科宝智慧医疗科技（上海）有限公司 用于液体分析的容器
USD768872S1 (en) 2012-12-12 2016-10-11 Hach Company Cuvette for a water analysis instrument
JP5708683B2 (ja) * 2013-02-26 2015-04-30 ソニー株式会社 マイクロチップ及びマイクロチップの製造方法
US20160107159A1 (en) * 2013-05-27 2016-04-21 Star Array Pte Ltd Microfluidic device and method for controlling fluid flow thereinto
JP2016522070A (ja) 2013-06-21 2016-07-28 インテュイティ メディカル インコーポレイテッド 可聴フィードバックを用いた分析物モニタリングシステム
WO2014210207A1 (en) 2013-06-25 2014-12-31 University Of Washington Through Its Center For Commercialization Self-digitization of sample volumes
EP3093665B1 (de) * 2014-01-10 2019-11-27 Konica Minolta, Inc. Immunoassay-verfahren und immunoassay-vorrichtung
KR20150101307A (ko) * 2014-02-26 2015-09-03 삼성전자주식회사 미세유동장치
JP2017516097A (ja) * 2014-05-15 2017-06-15 ゼネラル・エレクトリック・カンパニイ マイクロ流体フローセルアセンブリ及びその使用方法
KR20170072188A (ko) 2014-09-23 2017-06-26 티어랩 리서치, 인코포레이티드 미세 유체 눈물 포집 및 관심 대상인 분석물의 측방 유동 분석의 통합을 위한 시스템 및 방법
WO2016128843A2 (en) 2015-01-14 2016-08-18 Pixcell Medical Technologies Ltd. Disposable cartridge for sample fluid analysis
JP6607936B2 (ja) * 2015-06-08 2019-11-20 国立研究開発法人科学技術振興機構 高密度微小チャンバーアレイおよびこれを用いた測定方法
WO2017007954A1 (en) 2015-07-07 2017-01-12 University Of Washington Systems, methods, and devices for self-digitization of samples
US10775370B2 (en) 2015-07-17 2020-09-15 Stat-Diagnostica & Innovation, S.L. Fluidic system for performing assays
US10857536B2 (en) 2016-01-08 2020-12-08 Hewlett-Packard Development Company, L.P. Polymerase chain reaction device
EP3960295B1 (de) 2016-01-29 2023-01-04 Hewlett-Packard Development Company, L.P. Mikrofluidiksystem
CA3036051A1 (en) * 2016-09-06 2018-03-15 Debina Diagnostics, Inc. Nanodiamond particles and related devices and methods
US10328147B2 (en) 2017-03-24 2019-06-25 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Herpes simplex virus type-1(HSV-1) vaccine strain VC2 generating an anti-EHV-1 immune response
WO2020055474A2 (en) * 2018-06-21 2020-03-19 Trustees Of Dartmouth College Metal-organic frameworks for electrochemical detection of analytes
JPWO2020105628A1 (ja) * 2018-11-21 2021-09-30 株式会社ヨコオ 標的核酸の検出方法および標的核酸検出用パッケージ
EP3897981B1 (de) * 2018-12-20 2023-06-07 Imec VZW Adressierbare mikroreaktionskammeranordnung
WO2020183938A1 (ja) * 2019-03-08 2020-09-17 株式会社フコク マイクロ流路チップ
US20200384466A1 (en) * 2019-06-07 2020-12-10 General Automation Lab Technologies Inc. Loading and sealing sample on microfabricated chip
CN111257571A (zh) * 2020-02-27 2020-06-09 南京亿科人群健康研究院有限公司 一种快速检测动物包虫自然感染抗体的试剂盒

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3963355A (en) * 1972-05-22 1976-06-15 Mcdonnell Douglas Corporation Process and apparatus for analyzing specimens for the presence of microorganisms therein
US4038151A (en) * 1976-07-29 1977-07-26 Mcdonnell Douglas Corporation Card for use in an automated microbial detection system
US4704255A (en) * 1983-07-15 1987-11-03 Pandex Laboratories, Inc. Assay cartridge
US5229297A (en) * 1989-02-03 1993-07-20 Eastman Kodak Company Containment cuvette for PCR and method of use
US5252296A (en) * 1990-05-15 1993-10-12 Chiron Corporation Method and apparatus for biopolymer synthesis
US5455175A (en) * 1990-06-04 1995-10-03 University Of Utah Research Foundation Rapid thermal cycling device
US5182082A (en) * 1991-01-23 1993-01-26 Becton, Dickinson And Company Multiple aliquot device for distributing a liquid solution into a well
US5270183A (en) * 1991-02-08 1993-12-14 Beckman Research Institute Of The City Of Hope Device and method for the automated cycling of solutions between two or more temperatures
DE69331067T2 (de) * 1992-04-06 2002-07-11 Abbott Lab Verfahren und vorrichtung zum nachweis von nukleinsäure oder analysen unter verwendung der internen totalreflexion
US5498392A (en) * 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5296375A (en) * 1992-05-01 1994-03-22 Trustees Of The University Of Pennsylvania Mesoscale sperm handling devices
US5304487A (en) * 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
DE69303898T3 (de) * 1992-05-01 2007-01-18 Trustees Of The University Of Pennsylvania Fluessigkeitsbehandlung in mikrofabrizierten analytischen vorrichtungen
JPH07509361A (ja) * 1992-07-28 1995-10-19 日立化成工業株式会社 遺伝子検出システム
EP0672110B1 (de) * 1992-11-06 2000-09-13 Biolog, Inc. Testvorrichtung für flüssig- und suspensionsproben
US5591643A (en) * 1993-09-01 1997-01-07 Abaxis, Inc. Simplified inlet channels
US5409665A (en) * 1993-09-01 1995-04-25 Abaxis, Inc. Simultaneous cuvette filling with means to isolate cuvettes
ES2176308T3 (es) * 1993-10-28 2002-12-01 Houston Advanced Res Ct Dispositivo de microestructura porosa que permite un flujo.
CA2182513A1 (en) * 1994-02-01 1995-08-10 Robert E. Fields Molecular analyzer and method of use
US5595712A (en) * 1994-07-25 1997-01-21 E. I. Du Pont De Nemours And Company Chemical mixing and reaction apparatus
US6001229A (en) * 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
US5585069A (en) * 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5612473A (en) * 1996-01-16 1997-03-18 Gull Laboratories Methods, kits and solutions for preparing sample material for nucleic acid amplification
US5846727A (en) * 1996-06-06 1998-12-08 Board Of Supervisors Of Louisiana State University And Agricultural & Mechanical College Microsystem for rapid DNA sequencing

Also Published As

Publication number Publication date
EP0889751B1 (de) 1999-09-08
JP2009025313A (ja) 2009-02-05
US6126899A (en) 2000-10-03
AU706862B2 (en) 1999-06-24
JP4912517B2 (ja) 2012-04-11
EP0889751A1 (de) 1999-01-13
CA2250212A1 (en) 1997-10-09
AU2604897A (en) 1997-10-22
JP2011177179A (ja) 2011-09-15
WO1997036681A1 (en) 1997-10-09
DE69700499D1 (de) 1999-10-14
US6124138A (en) 2000-09-26
CA2250212C (en) 2010-02-09
JP2000508528A (ja) 2000-07-11

Similar Documents

Publication Publication Date Title
DE69700499T2 (de) Vorrichtung und verfahren zum nachweis mehrerer analyten
DE69710523T2 (de) Verfahren und Vorrichtung zum Detektieren von Eisenbahnaktivität
DE69727113D1 (de) Vorrichtung und Verfahren zum Reinigen
DE69633771D1 (de) Verfahren und gerät zum kontaktieren
DE69630519D1 (de) Vorrichtung und verfahren zum reinigen
DE69533028D1 (de) Vorrichtung und verfahren zum multiplexen von signalen
DE59508637D1 (de) Verfahren und Vorrichtung zum Stapeln
DE59805644D1 (de) Vorrichtung und verfahren zum halten und durchführen länglicher objekte
DE69900810D1 (de) Verfahren und Vorrichtung zum Testen von ereignisgesteuerten Programmen
DE69725429D1 (de) Verfahren und vorrichtung zum testen von katalysatoren
DE69505460T2 (de) Vorrichtung und Verfahren zum Prüfen von Banknoten
DE69715254D1 (de) Vorrichtung und Verfahren zum Reinigen
DE69524347D1 (de) Vorrichtung und Verfahren zum Wegmessung
DE59601324D1 (de) Verfahren und Vorrichtung zum Depalettieren
DE69717824T2 (de) Verfahren und vorrichtung zum software-test
DE69726854D1 (de) Verfahren und vorrichtung zum erkennen von herzschlag
DE69906537T2 (de) Vorrichtung und verfahren zum streckformen
DE69616613T2 (de) Verfahren und Vorrichtung zum Tiefziehen
DE69729779D1 (de) Verfahren und Vorrichtung zum Polieren
DE69928780D1 (de) Verfahren und vorrichtung zum formationstesten
DE69624822D1 (de) Vorrichtung und verfahren zum drucken
DE69624928D1 (de) Verfahren und vorrichtung zum bohren
DE69712945T2 (de) Vorrichtung und Verfahren zum Umschlagen von Reifenbestandteilen
DE69703103T2 (de) Vorrichtung und Verfahren zum Prüfen von Münzen
DE69530339D1 (de) Vorrichtung und Verfahren zum Drucken

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: APPLERA CORP., FOSTER CITY, CALIF., US

8327 Change in the person/name/address of the patent owner

Owner name: APPLIED BIOSYSTEMS, LLC (N. D. GES. D. STAATES, US

8380 Miscellaneous part iii

Free format text: PFANDRECHT

8380 Miscellaneous part iii

Free format text: PFANDRECHT AUFGEHOBEN