JP4523153B2 - 易溶性薬物の二層性放出制御送達システムおよび方法 - Google Patents

易溶性薬物の二層性放出制御送達システムおよび方法 Download PDF

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Publication number
JP4523153B2
JP4523153B2 JP2000536368A JP2000536368A JP4523153B2 JP 4523153 B2 JP4523153 B2 JP 4523153B2 JP 2000536368 A JP2000536368 A JP 2000536368A JP 2000536368 A JP2000536368 A JP 2000536368A JP 4523153 B2 JP4523153 B2 JP 4523153B2
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Prior art keywords
drug
metformin
release
particle layer
layer
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Expired - Lifetime
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JP2000536368A
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Japanese (ja)
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JP2002506812A5 (https=
JP2002506812A (ja
Inventor
ピーター・ティミンズ
アンドリュー・ビー・デニス
キレン・エイ・ブイアス
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2000536368A 1998-03-19 1999-03-10 易溶性薬物の二層性放出制御送達システムおよび方法 Expired - Lifetime JP4523153B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4444698A 1998-03-19 1998-03-19
US09/044,446 1998-03-19
PCT/US1999/005233 WO1999047128A1 (en) 1998-03-19 1999-03-10 Biphasic controlled release delivery system for high solubility pharmaceuticals and method

Publications (3)

Publication Number Publication Date
JP2002506812A JP2002506812A (ja) 2002-03-05
JP2002506812A5 JP2002506812A5 (https=) 2006-04-27
JP4523153B2 true JP4523153B2 (ja) 2010-08-11

Family

ID=21932435

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000536368A Expired - Lifetime JP4523153B2 (ja) 1998-03-19 1999-03-10 易溶性薬物の二層性放出制御送達システムおよび方法

Country Status (14)

Country Link
US (2) US6475521B1 (https=)
EP (2) EP1063973B1 (https=)
JP (1) JP4523153B2 (https=)
KR (1) KR100620935B1 (https=)
CN (1) CN1203846C (https=)
AP (1) AP1224A (https=)
AU (1) AU736951C (https=)
BR (1) BR9908911A (https=)
CA (1) CA2320900C (https=)
EA (1) EA003101B1 (https=)
ID (1) ID26082A (https=)
NZ (1) NZ506202A (https=)
OA (1) OA11484A (https=)
WO (1) WO1999047128A1 (https=)

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AP1224A (en) 2003-11-14
NZ506202A (en) 2003-10-31
ID26082A (id) 2000-11-23
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AU736951B2 (en) 2001-08-09
EP1063973A4 (en) 2008-11-19
EP1063973A1 (en) 2001-01-03
AP2000001885A0 (en) 2000-09-30
CA2320900C (en) 2009-10-27
WO1999047128A1 (en) 1999-09-23
CN1203846C (zh) 2005-06-01
EP1063973B1 (en) 2016-11-16
CA2320900A1 (en) 1999-09-23
EP2332522A2 (en) 2011-06-15
BR9908911A (pt) 2001-10-02
JP2002506812A (ja) 2002-03-05
EA200000968A1 (ru) 2001-06-25
OA11484A (en) 2004-05-03
US6660300B1 (en) 2003-12-09
KR20010041958A (ko) 2001-05-25
KR100620935B1 (ko) 2006-09-13
EP2332522A3 (en) 2011-12-07
EA003101B1 (ru) 2002-12-26
US6475521B1 (en) 2002-11-05
AU3182899A (en) 1999-10-11

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