NZ506202A - Biphasic controlled release delivery system for high solubility pharmaceuticals and method - Google Patents
Biphasic controlled release delivery system for high solubility pharmaceuticals and methodInfo
- Publication number
- NZ506202A NZ506202A NZ506202A NZ50620299A NZ506202A NZ 506202 A NZ506202 A NZ 506202A NZ 506202 A NZ506202 A NZ 506202A NZ 50620299 A NZ50620299 A NZ 50620299A NZ 506202 A NZ506202 A NZ 506202A
- Authority
- NZ
- New Zealand
- Prior art keywords
- metformin
- solid particulate
- pharmaceutical formulation
- drug
- pharmaceutical
- Prior art date
Links
- 238000013270 controlled release Methods 0.000 title claims abstract description 32
- 230000002051 biphasic effect Effects 0.000 title claims abstract description 25
- 238000000034 method Methods 0.000 title claims abstract description 15
- 239000003814 drug Substances 0.000 title description 152
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- 239000000463 material Substances 0.000 claims abstract description 39
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- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 18
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical group CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims description 87
- 229960003105 metformin Drugs 0.000 claims description 61
- 238000010521 absorption reaction Methods 0.000 claims description 28
- 150000003839 salts Chemical class 0.000 claims description 26
- OETHQSJEHLVLGH-UHFFFAOYSA-N metformin hydrochloride Chemical compound Cl.CN(C)C(=N)N=C(N)N OETHQSJEHLVLGH-UHFFFAOYSA-N 0.000 claims description 21
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- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 4
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4444698A | 1998-03-19 | 1998-03-19 | |
| PCT/US1999/005233 WO1999047128A1 (en) | 1998-03-19 | 1999-03-10 | Biphasic controlled release delivery system for high solubility pharmaceuticals and method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ506202A true NZ506202A (en) | 2003-10-31 |
Family
ID=21932435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ506202A NZ506202A (en) | 1998-03-19 | 1999-03-10 | Biphasic controlled release delivery system for high solubility pharmaceuticals and method |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6475521B1 (https=) |
| EP (2) | EP1063973B1 (https=) |
| JP (1) | JP4523153B2 (https=) |
| KR (1) | KR100620935B1 (https=) |
| CN (1) | CN1203846C (https=) |
| AP (1) | AP1224A (https=) |
| AU (1) | AU736951C (https=) |
| BR (1) | BR9908911A (https=) |
| CA (1) | CA2320900C (https=) |
| EA (1) | EA003101B1 (https=) |
| ID (1) | ID26082A (https=) |
| NZ (1) | NZ506202A (https=) |
| OA (1) | OA11484A (https=) |
| WO (1) | WO1999047128A1 (https=) |
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| WO2001035940A2 (en) * | 1999-11-16 | 2001-05-25 | Smithkline Beecham P.L.C. | Pharmaceutical composition comprising a thiazolidinedione-metformin hydrochloride |
| MY125516A (en) | 1999-11-16 | 2006-08-30 | Smithkline Beecham Plc | Novel composition based on thiazolidinedione and metformin and use |
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-
1999
- 1999-03-10 AP APAP/P/2000/001885A patent/AP1224A/en active
- 1999-03-10 EA EA200000968A patent/EA003101B1/ru not_active IP Right Cessation
- 1999-03-10 NZ NZ506202A patent/NZ506202A/en not_active IP Right Cessation
- 1999-03-10 KR KR1020007010280A patent/KR100620935B1/ko not_active Expired - Lifetime
- 1999-03-10 CN CNB998041343A patent/CN1203846C/zh not_active Expired - Lifetime
- 1999-03-10 JP JP2000536368A patent/JP4523153B2/ja not_active Expired - Lifetime
- 1999-03-10 ID IDW20001812A patent/ID26082A/id unknown
- 1999-03-10 BR BR9908911-4A patent/BR9908911A/pt not_active Application Discontinuation
- 1999-03-10 AU AU31828/99A patent/AU736951C/en not_active Expired
- 1999-03-10 CA CA002320900A patent/CA2320900C/en not_active Expired - Lifetime
- 1999-03-10 EP EP99913842.3A patent/EP1063973B1/en not_active Expired - Lifetime
- 1999-03-10 EP EP11160470A patent/EP2332522A3/en not_active Withdrawn
- 1999-03-10 WO PCT/US1999/005233 patent/WO1999047128A1/en not_active Ceased
- 1999-09-16 US US09/398,107 patent/US6475521B1/en not_active Expired - Lifetime
-
2000
- 2000-09-05 OA OA1200000242A patent/OA11484A/en unknown
-
2002
- 2002-08-21 US US10/224,945 patent/US6660300B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1295467A (zh) | 2001-05-16 |
| AP1224A (en) | 2003-11-14 |
| JP4523153B2 (ja) | 2010-08-11 |
| ID26082A (id) | 2000-11-23 |
| AU736951C (en) | 2003-02-20 |
| AU736951B2 (en) | 2001-08-09 |
| EP1063973A4 (en) | 2008-11-19 |
| EP1063973A1 (en) | 2001-01-03 |
| AP2000001885A0 (en) | 2000-09-30 |
| CA2320900C (en) | 2009-10-27 |
| WO1999047128A1 (en) | 1999-09-23 |
| CN1203846C (zh) | 2005-06-01 |
| EP1063973B1 (en) | 2016-11-16 |
| CA2320900A1 (en) | 1999-09-23 |
| EP2332522A2 (en) | 2011-06-15 |
| BR9908911A (pt) | 2001-10-02 |
| JP2002506812A (ja) | 2002-03-05 |
| EA200000968A1 (ru) | 2001-06-25 |
| OA11484A (en) | 2004-05-03 |
| US6660300B1 (en) | 2003-12-09 |
| KR20010041958A (ko) | 2001-05-25 |
| KR100620935B1 (ko) | 2006-09-13 |
| EP2332522A3 (en) | 2011-12-07 |
| EA003101B1 (ru) | 2002-12-26 |
| US6475521B1 (en) | 2002-11-05 |
| AU3182899A (en) | 1999-10-11 |
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| RENW | Renewal (renewal fees accepted) | ||
| PSEA | Patent sealed | ||
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| RENW | Renewal (renewal fees accepted) | ||
| EXPY | Patent expired |