JP4115671B2 - 長期間持続するインシュリン向性ペプチド - Google Patents

長期間持続するインシュリン向性ペプチド Download PDF

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Publication number
JP4115671B2
JP4115671B2 JP2000618327A JP2000618327A JP4115671B2 JP 4115671 B2 JP4115671 B2 JP 4115671B2 JP 2000618327 A JP2000618327 A JP 2000618327A JP 2000618327 A JP2000618327 A JP 2000618327A JP 4115671 B2 JP4115671 B2 JP 4115671B2
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Japan
Prior art keywords
fmoc
insulinotropic peptide
lys
modified
glp
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Expired - Fee Related
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JP2000618327A
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Japanese (ja)
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JP2003527312A (ja
Inventor
ドミニク ピー． ブライドン，
ベノイット ラーチェベック，
アラン エム． エズリン，
ダレン エル． ホルメス，
アノウク レブランク，
ピエール， サージ セント
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コンジュケム バイオテクノロジーズ インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Surgery (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Peptides Or Proteins (AREA)
JP2000618327A 1999-05-17 2000-05-17 長期間持続するインシュリン向性ペプチド Expired - Fee Related JP4115671B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13440699P 1999-05-17 1999-05-17
US60/134,406 1999-09-10
US15978399P 1999-10-15 1999-10-15
US60/159,783 1999-10-15
PCT/US2000/013563 WO2000069911A1 (en) 1999-05-17 2000-05-17 Long lasting insulinotropic peptides

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2005151458A Division JP4116016B2 (ja) 1999-05-17 2005-05-24 長時間持続するエキセンジン−４
JP2005361126A Division JP2006151986A (ja) 1999-05-17 2005-12-14 長時間持続するエキセンジン−４

Publications (2)

Publication Number Publication Date
JP2003527312A JP2003527312A (ja) 2003-09-16
JP4115671B2 true JP4115671B2 (ja) 2008-07-09

Family

ID=26832298

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2000618327A Expired - Fee Related JP4115671B2 (ja) 1999-05-17 2000-05-17 長期間持続するインシュリン向性ペプチド
JP2005151458A Expired - Fee Related JP4116016B2 (ja) 1999-05-17 2005-05-24 長時間持続するエキセンジン−４
JP2005361126A Withdrawn JP2006151986A (ja) 1999-05-17 2005-12-14 長時間持続するエキセンジン−４
JP2008187966A Pending JP2009007371A (ja) 1999-05-17 2008-07-18 長時間持続するエキセンジン−４
JP2008187967A Pending JP2009001583A (ja) 1999-05-17 2008-07-18 長時間持続するエキセンジン−４

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2005151458A Expired - Fee Related JP4116016B2 (ja) 1999-05-17 2005-05-24 長時間持続するエキセンジン−４
JP2005361126A Withdrawn JP2006151986A (ja) 1999-05-17 2005-12-14 長時間持続するエキセンジン−４
JP2008187966A Pending JP2009007371A (ja) 1999-05-17 2008-07-18 長時間持続するエキセンジン−４
JP2008187967A Pending JP2009001583A (ja) 1999-05-17 2008-07-18 長時間持続するエキセンジン−４

Country Status (16)

Country Link
US (4) US6329336B1 (enExample)
EP (1) EP1180121B9 (enExample)
JP (5) JP4115671B2 (enExample)
CN (1) CN1191273C (enExample)
AT (1) ATE252601T1 (enExample)
AU (1) AU754770B2 (enExample)
BR (1) BR0010750A (enExample)
CA (2) CA2363712C (enExample)
DE (1) DE60006100T2 (enExample)
DK (1) DK1180121T3 (enExample)
EA (1) EA003922B1 (enExample)
ES (1) ES2209885T3 (enExample)
NO (1) NO20015584L (enExample)
PT (1) PT1180121E (enExample)
SI (1) SI1180121T1 (enExample)
WO (1) WO2000069911A1 (enExample)

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* Cited by examiner, † Cited by third party
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US20060135428A1 (en) 2006-06-22
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US6329336B1 (en) 2001-12-11
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CA2363712C (en) 2011-05-10
CN1350548A (zh) 2002-05-22
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PT1180121E (pt) 2004-03-31
US6593295B2 (en) 2003-07-15
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