|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US4263428A
(en)
|
1978-03-24 |
1981-04-21 |
The Regents Of The University Of California |
Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
|
|
US4657760A
(en)
|
1979-03-20 |
1987-04-14 |
Ortho Pharmaceutical Corporation |
Methods and compositions using monoclonal antibody to human T cells
|
|
US4289872A
(en)
|
1979-04-06 |
1981-09-15 |
Allied Corporation |
Macromolecular highly branched homogeneous compound based on lysine units
|
|
ZA811368B
(en)
|
1980-03-24 |
1982-04-28 |
Genentech Inc |
Bacterial polypedtide expression employing tryptophan promoter-operator
|
|
EP0052322B1
(de)
|
1980-11-10 |
1985-03-27 |
Gersonde, Klaus, Prof. Dr. |
Verfahren zur Herstellung von Lipid-Vesikeln durch Ultraschallbehandlung, Anwendung des Verfahrens und Vorrichtung zur Durchführung des Verfahrens
|
|
IE52535B1
(en)
|
1981-02-16 |
1987-12-09 |
Ici Plc |
Continuous release pharmaceutical compositions
|
|
FR2504010B1
(fr)
|
1981-04-15 |
1985-10-25 |
Sanofi Sa |
Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation
|
|
US4551433A
(en)
|
1981-05-18 |
1985-11-05 |
Genentech, Inc. |
Microbial hybrid promoters
|
|
JPS57206622A
(en)
|
1981-06-10 |
1982-12-18 |
Ajinomoto Co Inc |
Blood substitute
|
|
US4485045A
(en)
|
1981-07-06 |
1984-11-27 |
Research Corporation |
Synthetic phosphatidyl cholines useful in forming liposomes
|
|
NZ201705A
(en)
|
1981-08-31 |
1986-03-14 |
Genentech Inc |
Recombinant dna method for production of hepatitis b surface antigen in yeast
|
|
DE3374837D1
(en)
|
1982-02-17 |
1988-01-21 |
Ciba Geigy Ag |
Lipids in the aqueous phase
|
|
US4671958A
(en)
|
1982-03-09 |
1987-06-09 |
Cytogen Corporation |
Antibody conjugates for the delivery of compounds to target sites
|
|
DE3218121A1
(de)
|
1982-05-14 |
1983-11-17 |
Leskovar, Peter, Dr.-Ing., 8000 München |
Arzneimittel zur tumorbehandlung
|
|
EP0102324A3
(de)
|
1982-07-29 |
1984-11-07 |
Ciba-Geigy Ag |
Lipide und Tenside in wässriger Phase
|
|
US5145962A
(en)
|
1982-08-12 |
1992-09-08 |
Howard Florey Institute Of Experimental Physiology And Medicine |
Human pro relaxin polypeptides
|
|
US5179195A
(en)
|
1982-12-13 |
1993-01-12 |
Howard Florey Institute Of Experimental Physiology And Medicine |
Human relaxin polypeptides
|
|
IL70414A
(en)
|
1982-12-13 |
1991-06-10 |
Florey Howard Inst |
Polypeptide having human h2-relaxin activity,double-stranded dna fragments coding therefor,vectors containing the dna fragments and methods for preparing the polypeptide,dna fragments and vectors
|
|
US4511502A
(en)
|
1982-12-22 |
1985-04-16 |
Genentech, Inc. |
Purification and activity assurance of precipitated heterologous proteins
|
|
US4511503A
(en)
|
1982-12-22 |
1985-04-16 |
Genentech, Inc. |
Purification and activity assurance of precipitated heterologous proteins
|
|
US4512922A
(en)
|
1982-12-22 |
1985-04-23 |
Genentech, Inc. |
Purification and activity assurance of precipitated heterologous proteins
|
|
US4820352A
(en)
|
1983-01-10 |
1989-04-11 |
Bausch & Lomb Incorporated |
Cleaning and conditioning solutions for contact lenses and methods of use
|
|
CA1341302C
(en)
|
1983-02-22 |
2001-10-09 |
Rae Lyn Burke |
Yeast expression systems with vectors having gapdh or pyk promoters and synthesis of foreign protein
|
|
US4876197A
(en)
|
1983-02-22 |
1989-10-24 |
Chiron Corporation |
Eukaryotic regulatable transcription
|
|
US5089398A
(en)
|
1983-02-22 |
1992-02-18 |
Chiron Corporation |
Enhanced yeast transcription employing hybrid GAPDH promoter region constructs
|
|
JPS59166086A
(ja)
|
1983-03-09 |
1984-09-19 |
Teruhiko Beppu |
新規な発現型プラスミドとそれらを用いて仔牛プロキモシン遺伝子を大腸菌内で発現させる方法
|
|
US4755465A
(en)
|
1983-04-25 |
1988-07-05 |
Genentech, Inc. |
Secretion of correctly processed human growth hormone in E. coli and Pseudomonas
|
|
US4859600A
(en)
|
1983-04-25 |
1989-08-22 |
Genentech, Inc. |
Recombinant procaryotic cell containing correctly processed human growth hormone
|
|
IE58011B1
(en)
|
1983-05-27 |
1993-06-16 |
Texas A & M Univ Sys |
Method for producing a recombinant baculovirus expression vector
|
|
US4544545A
(en)
|
1983-06-20 |
1985-10-01 |
Trustees University Of Massachusetts |
Liposomes containing modified cholesterol for organ targeting
|
|
JPS607934A
(ja)
|
1983-06-29 |
1985-01-16 |
Dai Ichi Seiyaku Co Ltd |
リポソ−ムの製造方法
|
|
HUT35524A
(en)
|
1983-08-02 |
1985-07-29 |
Hoechst Ag |
Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
|
|
US4689406A
(en)
|
1983-08-10 |
1987-08-25 |
Amgen |
Enhancement of microbial expression of polypeptides
|
|
DE3483949D1
(de)
|
1983-09-26 |
1991-02-21 |
Udo Dr Med Ehrenfeld |
Mittel und erzeugnis fuer die diagnose und therapie von tumoren sowie zur behandlung von schwaechen der zelligen und humoralen immunabwehr.
|
|
EP0143949B1
(en)
|
1983-11-01 |
1988-10-12 |
TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION |
Pharmaceutical composition containing urokinase
|
|
ZA848495B
(en)
|
1984-01-31 |
1985-09-25 |
Idaho Res Found |
Production of polypeptides in insect cells
|
|
EP0154316B1
(en)
|
1984-03-06 |
1989-09-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified lymphokine and production thereof
|
|
US4880734A
(en)
|
1984-05-11 |
1989-11-14 |
Chiron Corporation |
Eukaryotic regulatable transcription
|
|
DE3587759T2
(de)
|
1984-05-11 |
1994-07-07 |
Chiron Corp., Emeryville, Calif. |
Erhöhte Hefetranskription unter Verwendung einer Hybridkonstruktion der Promotorregion.
|
|
US4542225A
(en)
|
1984-08-29 |
1985-09-17 |
Dana-Farber Cancer Institute, Inc. |
Acid-cleavable compound
|
|
US4738921A
(en)
|
1984-09-27 |
1988-04-19 |
Eli Lilly And Company |
Derivative of the tryptophan operon for expression of fused gene products
|
|
US4659839A
(en)
|
1984-10-10 |
1987-04-21 |
Mallinckrodt, Inc. |
Coupling agents for radiolabeled antibody fragments
|
|
US4837148A
(en)
|
1984-10-30 |
1989-06-06 |
Phillips Petroleum Company |
Autonomous replication sequences for yeast strains of the genus pichia
|
|
GB8430252D0
(en)
|
1984-11-30 |
1985-01-09 |
Beecham Group Plc |
Compounds
|
|
EP0188256B1
(en)
|
1985-01-14 |
1991-08-21 |
NeoRx |
Metal radionuclide labeled proteins for diagnosis and therapy
|
|
DE3675588D1
(de)
|
1985-06-19 |
1990-12-20 |
Ajinomoto Kk |
Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
|
|
US5206344A
(en)
|
1985-06-26 |
1993-04-27 |
Cetus Oncology Corporation |
Interleukin-2 muteins and polymer conjugation thereof
|
|
DE3676670D1
(de)
|
1985-06-26 |
1991-02-07 |
Cetus Corp |
Solubilisierung von proteinen fuer pharmazeutische zusammensetzungen mittels polymerkonjugierung.
|
|
US4680338A
(en)
|
1985-10-17 |
1987-07-14 |
Immunomedics, Inc. |
Bifunctional linker
|
|
US4699784A
(en)
|
1986-02-25 |
1987-10-13 |
Center For Molecular Medicine & Immunology |
Tumoricidal methotrexate-antibody conjugate
|
|
GB8610600D0
(en)
|
1986-04-30 |
1986-06-04 |
Novo Industri As |
Transformation of trichoderma
|
|
JPS63123383A
(ja)
|
1986-11-11 |
1988-05-27 |
Mitsubishi Kasei Corp |
ハイブリツドプロモ−タ−、発現調節ｄｎａ配列および発現ベクタ−
|
|
US5186933A
(en)
|
1986-12-30 |
1993-02-16 |
Baylor College Of Medicine |
Synthesis and immunogenicity of rotavirus genes using a baculovirus expression system
|
|
WO1988007082A1
(en)
|
1987-03-16 |
1988-09-22 |
American Biogenetic Sciences, Inc. |
Recombinant baculovirus occlusion bodies in vaccines and biological insecticides
|
|
EP0284044B1
(en)
|
1987-03-23 |
1994-03-23 |
Zymogenetics, Inc. |
High level expression in yeast
|
|
US5229490A
(en)
|
1987-05-06 |
1993-07-20 |
The Rockefeller University |
Multiple antigen peptide system
|
|
AU2251488A
(en)
|
1987-07-24 |
1989-03-01 |
Cetus Corporation |
Production of biologically active forms of csf using a baculovirus (acnpv)-insect cell expression system
|
|
WO1989001037A1
(en)
|
1987-07-24 |
1989-02-09 |
Cetus Corporation |
Production of ricin toxins in a baculovirus-insect cell expression system
|
|
US5080891A
(en)
|
1987-08-03 |
1992-01-14 |
Ddi Pharmaceuticals, Inc. |
Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
|
|
US4929555A
(en)
|
1987-10-19 |
1990-05-29 |
Phillips Petroleum Company |
Pichia transformation
|
|
US4904584A
(en)
|
1987-12-23 |
1990-02-27 |
Genetics Institute, Inc. |
Site-specific homogeneous modification of polypeptides
|
|
CA1340772C
(en)
|
1987-12-30 |
1999-09-28 |
Patricia Tekamp-Olson |
Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences
|
|
US4847325A
(en)
|
1988-01-20 |
1989-07-11 |
Cetus Corporation |
Conjugation of polymer to colony stimulating factor-1
|
|
DE68906153T2
(de)
|
1988-02-26 |
1993-10-28 |
Genentech Inc |
Humanes relaxinpräparat.
|
|
US5674706A
(en)
|
1988-05-06 |
1997-10-07 |
Chiron Corporation |
High level expression of proteins in yeast
|
|
CA1324969C
(en)
|
1988-05-06 |
1993-12-07 |
Jeffrey R. Shuster |
High level expression of proteins in yeast
|
|
FR2631974B1
(fr)
|
1988-05-31 |
1992-12-11 |
Agronomique Inst Nat Rech |
Baculovirus modifie, son procede de preparation et son application en tant que vecteur d'expression de genes
|
|
WO1990001556A1
(en)
|
1988-08-05 |
1990-02-22 |
Mount Sinai School Of Medicine Of The City University Of New York |
In vivo infection of live insects with a recombinant baculovirus
|
|
GB8819453D0
(en)
|
1988-08-16 |
1988-09-21 |
Roy P |
Production of bluetongue virus non-structural proteins using baculovirus expression vector
|
|
NZ230425A
(en)
|
1988-09-02 |
1992-07-28 |
Molecular Eng Ass |
Production of paramyxovirus fusion (f) protein using recombinant baculovirus expression vector
|
|
GB8824591D0
(en)
|
1988-10-20 |
1988-11-23 |
Royal Free Hosp School Med |
Fractionation process
|
|
EP0397834B1
(en)
|
1988-10-28 |
2000-02-02 |
Genentech, Inc. |
Method for identifying active domains and amino acid residues in polypeptides and hormone variants
|
|
US6780613B1
(en)
|
1988-10-28 |
2004-08-24 |
Genentech, Inc. |
Growth hormone variants
|
|
AU649217B2
(en)
|
1988-11-18 |
1994-05-19 |
Regents Of The University Of California, The |
Method for site-specifically incorporating unnatural amino acids into proteins
|
|
EP0401384B1
(en)
|
1988-12-22 |
1996-03-13 |
Kirin-Amgen, Inc. |
Chemically modified granulocyte colony stimulating factor
|
|
US4902502A
(en)
|
1989-01-23 |
1990-02-20 |
Cetus Corporation |
Preparation of a polymer/interleukin-2 conjugate
|
|
WO1990010078A1
(en)
|
1989-02-23 |
1990-09-07 |
University Of Ottawa |
Improved baculovirus expression system capable of producing foreign gene proteins at high levels
|
|
EP0460071A4
(en)
|
1989-02-24 |
1993-02-03 |
Cell Analysis Systems, Inc. |
Method and apparatus for determining a proliferation index of a cell sample
|
|
US5122614A
(en)
|
1989-04-19 |
1992-06-16 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
|
US5324844A
(en)
|
1989-04-19 |
1994-06-28 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
|
EP0470128B2
(en)
|
1989-04-19 |
2003-08-13 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
|
WO1990014428A1
(en)
|
1989-05-17 |
1990-11-29 |
University Of Georgia Research Foundation, Inc. |
Improved baculovirus expression vectors
|
|
DE69026306T2
(de)
|
1989-05-27 |
1996-10-17 |
Seikagaku Kogyo Co Ltd |
Verfahren für die Herstellung von Polyethylenglykolderivate und modifizierte Proteine.
|
|
FR2649120B1
(fr)
|
1989-06-30 |
1994-01-28 |
Cayla |
Nouvelle souche et ses mutants de champignons filamenteux, procede de production de proteines recombinantes a l'aide de ladite souche et souches et proteines obtenues selon ce procede
|
|
US5225212A
(en)
|
1989-10-20 |
1993-07-06 |
Liposome Technology, Inc. |
Microreservoir liposome composition and method
|
|
US5312808A
(en)
|
1989-11-22 |
1994-05-17 |
Enzon, Inc. |
Fractionation of polyalkylene oxide-conjugated hemoglobin solutions
|
|
US5162601A
(en)
|
1989-11-22 |
1992-11-10 |
The Upjohn Company |
Plant potyvirus expression vector with a gene for protease
|
|
US5219564A
(en)
|
1990-07-06 |
1993-06-15 |
Enzon, Inc. |
Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
|
|
FR2664905B1
(fr)
|
1990-07-18 |
1994-08-12 |
Agronomique Inst Nat Rech |
Baculovirus modifie, son procede d'obtention, et vecteurs d'expression obtenus a partir dudit baculovirus.
|
|
WO1992001800A1
(en)
|
1990-07-20 |
1992-02-06 |
Chiron Corporation |
Method for integrative transformation of yeast using dispersed repetitive elements
|
|
EP0541721A4
(en)
|
1990-08-02 |
1993-12-29 |
Chiron Corporation |
Expression of human cmv glycoprotein-h using the baculovirus-insect cell expression system
|
|
EP0548267A4
(en)
|
1990-09-04 |
1994-11-23 |
Salk Inst Biotech Ind |
Production of insulin-like growth factor-1 in methylotrophic yeast cells
|
|
US5492821A
(en)
|
1990-11-14 |
1996-02-20 |
Cargill, Inc. |
Stabilized polyacrylic saccharide protein conjugates
|
|
US5252714A
(en)
|
1990-11-28 |
1993-10-12 |
The University Of Alabama In Huntsville |
Preparation and use of polyethylene glycol propionaldehyde
|
|
CA2405246A1
(en)
|
1990-12-03 |
1992-06-11 |
Genentech, Inc. |
Enrichment method for variant proteins with alterred binding properties
|
|
US5231178A
(en)
|
1991-01-16 |
1993-07-27 |
The Salk Institute Biotechnology/Industrial Associates, Inc. |
Method for the purification of intact, correctly-folded insulin-like growth factor-1
|
|
WO1992016555A1
(en)
|
1991-03-18 |
1992-10-01 |
Enzon, Inc. |
Hydrazine containing conjugates of polypeptides and glycopolypeptides with polymers
|
|
WO1992016619A1
(en)
|
1991-03-19 |
1992-10-01 |
Us Army |
Expression of influenza nucleoprotein antigens in baculovirus
|
|
US5595732A
(en)
|
1991-03-25 |
1997-01-21 |
Hoffmann-La Roche Inc. |
Polyethylene-protein conjugates
|
|
US6013433A
(en)
|
1991-04-26 |
2000-01-11 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Baculovirus expression vectors and recombinant antigens for detecting type-specific antibodies to herpes simplex virus
|
|
US5281698A
(en)
|
1991-07-23 |
1994-01-25 |
Cetus Oncology Corporation |
Preparation of an activated polymer ester for protein conjugation
|
|
US5290686A
(en)
|
1991-07-31 |
1994-03-01 |
The United States Of America As Represented By The Department Of Health And Human Services |
Expression of influenza a M2 protein in baculovirus
|
|
US5166191A
(en)
|
1991-08-19 |
1992-11-24 |
Genentech, Inc. |
Use of relaxin in cardiovascular therapy
|
|
US6256642B1
(en)
|
1992-01-29 |
2001-07-03 |
Microsoft Corporation |
Method and system for file system management using a flash-erasable, programmable, read-only memory
|
|
IT1260468B
(it)
|
1992-01-29 |
1996-04-09 |
|
Metodo per mantenere l'attivita' di enzimi proteolitici modificati con polietilenglicole
|
|
CA2118130A1
(en)
|
1992-04-14 |
1993-10-28 |
Jean M. J. Frechet |
Dendritic based macromolecules and method of production
|
|
US5516657A
(en)
|
1992-05-11 |
1996-05-14 |
Cambridge Biotech Corporation |
Baculovirus vectors for expression of secretory and membrane-bound proteins
|
|
ZA933926B
(en)
|
1992-06-17 |
1994-01-03 |
Amgen Inc |
Polyoxymethylene-oxyethylene copolymers in conjuction with blomolecules
|
|
AU5006993A
(en)
|
1992-08-21 |
1994-03-15 |
Enzon, Inc. |
Novel attachment of polyalkylene oxides to bio-effecting substances
|
|
US5382657A
(en)
|
1992-08-26 |
1995-01-17 |
Hoffmann-La Roche Inc. |
Peg-interferon conjugates
|
|
NZ250375A
(en)
|
1992-12-09 |
1995-07-26 |
Ortho Pharma Corp |
Peg hydrazone and peg oxime linkage forming reagents and protein derivatives
|
|
US5298643A
(en)
|
1992-12-22 |
1994-03-29 |
Enzon, Inc. |
Aryl imidate activated polyalkylene oxides
|
|
AU6029594A
(en)
|
1993-01-15 |
1994-08-15 |
Enzon, Inc. |
Factor viii - polymeric conjugates
|
|
US5349001A
(en)
|
1993-01-19 |
1994-09-20 |
Enzon, Inc. |
Cyclic imide thione activated polyalkylene oxides
|
|
US5321095A
(en)
|
1993-02-02 |
1994-06-14 |
Enzon, Inc. |
Azlactone activated polyalkylene oxides
|
|
US5532142A
(en)
|
1993-02-12 |
1996-07-02 |
Board Of Regents, The University Of Texas System |
Method of isolation and purification of fusion polypeptides
|
|
IL104734A0
(en)
|
1993-02-15 |
1993-06-10 |
Univ Bar Ilan |
Bioactive conjugates of cellulose with amino compounds
|
|
WO1994028024A1
(en)
|
1993-06-01 |
1994-12-08 |
Enzon, Inc. |
Carbohydrate-modified polymer conjugates with erythropoietic activity
|
|
WO1995000162A1
(en)
|
1993-06-21 |
1995-01-05 |
Enzon, Inc. |
Site specific synthesis of conjugated peptides
|
|
EP0707650B1
(en)
|
1993-06-21 |
2003-05-21 |
Genentech, Inc. |
Process for producing human relaxin
|
|
GB9317618D0
(en)
|
1993-08-24 |
1993-10-06 |
Royal Free Hosp School Med |
Polymer modifications
|
|
US5762939A
(en)
|
1993-09-13 |
1998-06-09 |
Mg-Pmc, Llc |
Method for producing influenza hemagglutinin multivalent vaccines using baculovirus
|
|
US5643575A
(en)
|
1993-10-27 |
1997-07-01 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5919455A
(en)
|
1993-10-27 |
1999-07-06 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5491076A
(en)
|
1993-11-01 |
1996-02-13 |
The Texas A&M University System |
Expression of foreign genes using a replicating polyprotein producing virus vector
|
|
US5605792A
(en)
|
1993-11-04 |
1997-02-25 |
The Ohio State University Research Foundation |
Infectious bursal disease virus VP2 fusion protein expressed by baculovirus, use as diagnostic
|
|
US5951974A
(en)
|
1993-11-10 |
1999-09-14 |
Enzon, Inc. |
Interferon polymer conjugates
|
|
KR960705579A
(ko)
|
1993-11-10 |
1996-11-08 |
에릭에스. 딕커 |
개선된 인터페론 중합체 결합체(Improved interferon polymer conjugates)
|
|
US5446090A
(en)
|
1993-11-12 |
1995-08-29 |
Shearwater Polymers, Inc. |
Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
|
|
FR2715664B1
(fr)
|
1994-01-31 |
1996-04-12 |
Proteine Performance Sa |
Baculovirus recombinant et son utilisation pour la production d'anticorps monoclonaux.
|
|
US6852507B1
(en)
|
1994-01-31 |
2005-02-08 |
L'institut National De La Recherche Agronomique |
Recombinant baculovirus and use thereof in the production of monoclonal antibodies
|
|
JP3090586B2
(ja)
|
1994-03-15 |
2000-09-25 |
片倉工業株式会社 |
システインプロテアーゼ遺伝子欠損バキュロウイルスおよびその製造法並びにこれを利用する有用タンパク質の製造法
|
|
US5473034A
(en)
|
1994-03-18 |
1995-12-05 |
Hyogo Prefectural Government |
Method for producing protein-synthetic polymer conjugate and said conjugate produced thereby
|
|
US5629384A
(en)
|
1994-05-17 |
1997-05-13 |
Consiglio Nazionale Delle Ricerche |
Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces
|
|
WO1995033490A1
(en)
|
1994-06-02 |
1995-12-14 |
Enzon, Inc. |
Method of solubilizing substantially water insoluble materials
|
|
US5730990A
(en)
|
1994-06-24 |
1998-03-24 |
Enzon, Inc. |
Non-antigenic amine derived polymers and polymer conjugates
|
|
US6403375B1
(en)
|
1994-08-24 |
2002-06-11 |
Boyce Thompson Institute For Plant Research, Inc. |
Establishment of Trichoplusia ni cell lines in serum-free medium for recombinant protein and baculovirus production
|
|
US5650234A
(en)
|
1994-09-09 |
1997-07-22 |
Surface Engineering Technologies, Division Of Innerdyne, Inc. |
Electrophilic polyethylene oxides for the modification of polysaccharides, polypeptides (proteins) and surfaces
|
|
US5871986A
(en)
|
1994-09-23 |
1999-02-16 |
The General Hospital Corporation |
Use of a baculovirus to express and exogenous gene in a mammalian cell
|
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
|
WO1996041813A2
(en)
|
1994-11-09 |
1996-12-27 |
Offord Robin E |
Functionalized polymers for site-specific attachment
|
|
US5738846A
(en)
|
1994-11-10 |
1998-04-14 |
Enzon, Inc. |
Interferon polymer conjugates and process for preparing the same
|
|
US5932462A
(en)
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
|
WO1996025496A1
(en)
|
1995-02-17 |
1996-08-22 |
Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) |
PRODUCTION OF BIOLOGICALLY ACTIVE RECOMBINANT BOVINE FOLLICLE STIMULATING HORMONE (REC bFSH) IN THE BACULOVIRUS EXPRESSION SYSTEM
|
|
FR2732035B1
(fr)
|
1995-03-23 |
1997-05-30 |
Agronomique Inst Nat Rech |
Procede de regulation de l'expression d'un gene dans un baculovirus, par un site de fixation d'un recepteur de l'acide retinoique, et vecteur pour la mise en oeuvre du dit procede
|
|
NZ308772A
(en)
|
1995-05-17 |
1999-04-29 |
Du Pont |
Recombinant baculovirus insecticides
|
|
AU5893696A
(en)
|
1995-06-07 |
1996-12-30 |
Novo Nordisk A/S |
Modification of polypeptides
|
|
US5911997A
(en)
|
1995-06-07 |
1999-06-15 |
Connetics Corporation |
Relaxin-like factor and methods and uses thereof
|
|
US5672662A
(en)
|
1995-07-07 |
1997-09-30 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
|
|
US5861279A
(en)
|
1996-01-17 |
1999-01-19 |
Schering Corporation |
Baculovirus expression system for human interleukin 5 receptor and method of screening for interleukin 5 antagonists
|
|
WO1997026332A1
(en)
|
1996-01-17 |
1997-07-24 |
Schering Corporation |
Baculovirus expression system for human interleukin 5 receptor and method of screening for interleukin 5 antagonists
|
|
US5747639A
(en)
|
1996-03-06 |
1998-05-05 |
Amgen Boulder Inc. |
Use of hydrophobic interaction chromatography to purify polyethylene glycols
|
|
TW517067B
(en)
|
1996-05-31 |
2003-01-11 |
Hoffmann La Roche |
Interferon conjugates
|
|
EP1731174A3
(en)
|
1996-08-02 |
2007-01-17 |
Ortho-McNeil Pharmaceutical, Inc. |
Polypeptides having a covalently bound N-terminal polyethylene glycol via hydrazone or oxime bond
|
|
US5980948A
(en)
|
1996-08-16 |
1999-11-09 |
Osteotech, Inc. |
Polyetherester copolymers as drug delivery matrices
|
|
US6214966B1
(en)
|
1996-09-26 |
2001-04-10 |
Shearwater Corporation |
Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
|
|
DE69725881T2
(de)
|
1996-12-13 |
2004-09-09 |
Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville |
Verfahren zur expression von heterologen proteinen in hefe
|
|
DE69800640T2
(de)
|
1997-01-29 |
2001-07-05 |
Polymasc Pharmaceuticals Plc, London |
Pegylationsverfahren
|
|
GB9703406D0
(en)
|
1997-02-19 |
1997-04-09 |
Chiron Spa |
Expression of heterologous proteins
|
|
EP0981548A4
(en)
|
1997-04-30 |
2005-11-23 |
Enzon Inc |
GLYCOSYLATABLE SINGLE CHAIN ANTIGEN-BINDING PROTEINS, MANUFACTURE AND USE THEREOF
|
|
US5990237A
(en)
|
1997-05-21 |
1999-11-23 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
|
|
WO1998055500A1
(en)
|
1997-06-06 |
1998-12-10 |
Kyowa Hakko Kogyo Co., Ltd. |
Chemically modified polypeptides
|
|
US5965393A
(en)
|
1997-07-01 |
1999-10-12 |
National Institute Of Immunology |
Method for enhancing foreign gene expression in baculovirus expression vector system
|
|
ATE375363T1
(de)
|
1997-07-14 |
2007-10-15 |
Bolder Biotechnology Inc |
Derivate des wachstumshormons und verwandte proteine
|
|
GB9715660D0
(en)
|
1997-07-25 |
1997-10-01 |
Zeneca Ltd |
Proteins
|
|
EP1003889A1
(en)
|
1997-08-05 |
2000-05-31 |
Chiron Corporation |
NOVEL $i(PICHIA PASTORIS) GENE SEQUENCES AND METHODS FOR THEIR USE
|
|
DE19735593C2
(de)
|
1997-08-15 |
1999-08-26 |
Hepavec Ag Fuer Gentherapie |
Hüllprotein-modifizierter Baculovirus-Vektor für die Gentherapie
|
|
US6090584A
(en)
|
1997-08-21 |
2000-07-18 |
University Technologies International Inc. |
Baculovirus artificial chromosomes and methods of use
|
|
PT1538206E
(pt)
|
1997-09-16 |
2010-04-12 |
Centocor Ortho Biotech Inc |
Método para a síntese química e construção completa de genes e genomas
|
|
US6129912A
(en)
|
1997-09-26 |
2000-10-10 |
Uab Research Foundation |
Polyethylene glycol-protein compositions which reduce the antigenic display of red blood cells
|
|
US6004573A
(en)
|
1997-10-03 |
1999-12-21 |
Macromed, Inc. |
Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
|
|
US6201072B1
(en)
|
1997-10-03 |
2001-03-13 |
Macromed, Inc. |
Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
|
|
DE19748489A1
(de)
|
1997-11-03 |
1999-05-06 |
Roche Diagnostics Gmbh |
Polyethylenglykol-derivatisierte Biomoleküle und deren Verwendung in heterogenen Nachweisverfahren
|
|
US6448369B1
(en)
|
1997-11-06 |
2002-09-10 |
Shearwater Corporation |
Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
|
|
EP0924298A1
(en)
|
1997-12-18 |
1999-06-23 |
Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) |
Protein expression in baculovirus vector expression systems
|
|
US5985263A
(en)
|
1997-12-19 |
1999-11-16 |
Enzon, Inc. |
Substantially pure histidine-linked protein polymer conjugates
|
|
US5981709A
(en)
|
1997-12-19 |
1999-11-09 |
Enzon, Inc. |
α-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same
|
|
CA2321261A1
(en)
|
1998-03-04 |
1999-09-10 |
Onyx Pharmaceuticals, Inc. |
Baculovirus expression system and method for high throughput expression of genetic material
|
|
JP2002505338A
(ja)
|
1998-03-05 |
2002-02-19 |
カイロン コーポレイション |
生物学的に活性な分子の血清半減期を増加するための方法
|
|
DK1411075T3
(da)
|
1998-03-12 |
2008-10-27 |
Nektar Therapeutics Al Corp |
Fremgangsmåde til fremstilling af polymerkonjugater
|
|
KR100264953B1
(ko)
|
1998-04-03 |
2001-03-02 |
박현우 |
재조합 베큘로바이러스, 이의 제조방법 및 이를 포함하는 미생물 살충제
|
|
US6451986B1
(en)
|
1998-06-22 |
2002-09-17 |
Immunex Corporation |
Site specific protein modification
|
|
US6168932B1
(en)
|
1998-07-13 |
2001-01-02 |
Parker Hughes Institute |
Recombinant DTctGMCSF fusion toxin in a baculovirus expression vector system
|
|
US6245528B1
(en)
|
1998-07-28 |
2001-06-12 |
Academia Sinica |
Latent baculovirus expression system
|
|
DE19834047A1
(de)
|
1998-07-29 |
2000-02-03 |
Bayer Ag |
Substituierte Pyrazolderivate
|
|
DE19834044A1
(de)
|
1998-07-29 |
2000-02-03 |
Bayer Ag |
Neue substituierte Pyrazolderivate
|
|
US6368825B1
(en)
|
1998-08-10 |
2002-04-09 |
Academia Sinica |
Baculovirus containing minimal CMV promoter
|
|
US6552167B1
(en)
|
1998-08-28 |
2003-04-22 |
Gryphon Therapeutics, Inc. |
Polyamide chains of precise length
|
|
WO2000020032A1
(en)
|
1998-10-06 |
2000-04-13 |
Trustees Of Dartmouth College |
RECOMBINANT CAT ALLERGEN, Fel dI, EXPRESSED IN BACULOVIRUS FOR DIAGNOSIS AND TREATMENT OF CAT ALLERGY
|
|
US6420339B1
(en)
|
1998-10-14 |
2002-07-16 |
Amgen Inc. |
Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
|
|
DE69936351T2
(de)
|
1998-10-30 |
2008-02-21 |
Novozymes A/S |
Glykosylierte proteine mit reduzierter allergenität
|
|
US6451346B1
(en)
|
1998-12-23 |
2002-09-17 |
Amgen Inc |
Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents
|
|
US6281211B1
(en)
|
1999-02-04 |
2001-08-28 |
Euro-Celtique S.A. |
Substituted semicarbazides and the use thereof
|
|
US6342216B1
(en)
|
1999-03-17 |
2002-01-29 |
The Board Of Regents, The University Of Texas System |
Therapy of cancer by insect cells containing recombinant baculovirus encoding genes
|
|
US6994986B2
(en)
|
1999-03-17 |
2006-02-07 |
The Board Of Trustees Of The Leland Stanford University |
In vitro synthesis of polypeptides by optimizing amino acid metabolism
|
|
JP4707237B2
(ja)
|
1999-03-17 |
2011-06-22 |
ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ |
外因性アミノ酸および新規ａｔｐ再生システムを用いたインビトロ高分子生合成の方法
|
|
US6337191B1
(en)
|
1999-03-22 |
2002-01-08 |
The Board Of Trustees Of The Leland Stanford Junior University |
Vitro protein synthesis using glycolytic intermediates as an energy source
|
|
JP2002542349A
(ja)
|
1999-04-16 |
2002-12-10 |
ダブリューエム・マーシュ・ライス・ユニバーシティー |
ポリ（プロピレンフマラート）−ジアクリレートマクロマーで交差結合された生体分解性のポリ（プロピレンフマラート）ネットワーク
|
|
US6261805B1
(en)
|
1999-07-15 |
2001-07-17 |
Boyce Thompson Institute For Plant Research, Inc. |
Sialyiation of N-linked glycoproteins in the baculovirus expression vector system
|
|
DE19943639A1
(de)
|
1999-09-13 |
2001-03-15 |
Bayer Ag |
Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften
|
|
DE19943635A1
(de)
|
1999-09-13 |
2001-03-15 |
Bayer Ag |
Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
|
|
DE19943636A1
(de)
|
1999-09-13 |
2001-03-15 |
Bayer Ag |
Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
|
|
DE19943634A1
(de)
|
1999-09-13 |
2001-04-12 |
Bayer Ag |
Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
|
|
US6485937B1
(en)
|
1999-10-15 |
2002-11-26 |
The Rockefeller University |
System for rapid generation of recombinant baculovirus-based expression vectors for silkworm larvae
|
|
US6348558B1
(en)
|
1999-12-10 |
2002-02-19 |
Shearwater Corporation |
Hydrolytically degradable polymers and hydrogels made therefrom
|
|
DK1259563T4
(en)
|
1999-12-22 |
2016-11-21 |
Nektar Therapeutics |
PROCEDURE FOR PREPARING 1-BENZOTRIAZOLYL CARBONATE ESTERS OF WATER SOLUBLE POLYMERS
|
|
AU781839B2
(en)
|
1999-12-22 |
2005-06-16 |
Nektar Therapeutics |
Sterically hindered derivatives of water soluble polymers
|
|
US6413507B1
(en)
|
1999-12-23 |
2002-07-02 |
Shearwater Corporation |
Hydrolytically degradable carbamate derivatives of poly (ethylene glycol)
|
|
US6646110B2
(en)
|
2000-01-10 |
2003-11-11 |
Maxygen Holdings Ltd. |
G-CSF polypeptides and conjugates
|
|
WO2001062827A2
(en)
|
2000-02-22 |
2001-08-30 |
Shearwater Corporation |
N-maleimidyl polymer derivatives
|
|
AU2001257577A1
(en)
|
2000-02-28 |
2001-09-03 |
Shearwater Corporation |
Water-soluble polymer conjugates of artelinic acid
|
|
US6586207B2
(en)
|
2000-05-26 |
2003-07-01 |
California Institute Of Technology |
Overexpression of aminoacyl-tRNA synthetases for efficient production of engineered proteins containing amino acid analogues
|
|
GB0012997D0
(en)
|
2000-05-26 |
2000-07-19 |
Eurogene Limited |
Gene delivery
|
|
JP2002030098A
(ja)
|
2000-07-17 |
2002-01-29 |
Institute Of Immunology Co Ltd |
バキュロウィルスの発芽ウイルスからウイルスエンベロープを回収する方法
|
|
US6436386B1
(en)
|
2000-11-14 |
2002-08-20 |
Shearwater Corporation |
Hydroxyapatite-targeting poly (ethylene glycol) and related polymers
|
|
AR031176A1
(es)
|
2000-11-22 |
2003-09-10 |
Bayer Ag |
Nuevos derivados de pirazolpiridina sustituidos con piridina
|
|
TW593427B
(en)
|
2000-12-18 |
2004-06-21 |
Nektar Therapeutics Al Corp |
Synthesis of high molecular weight non-peptidic polymer derivatives
|
|
TWI246524B
(en)
|
2001-01-19 |
2006-01-01 |
Shearwater Corp |
Multi-arm block copolymers as drug delivery vehicles
|
|
DE10110750A1
(de)
|
2001-03-07 |
2002-09-12 |
Bayer Ag |
Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
|
|
DE10110749A1
(de)
|
2001-03-07 |
2002-09-12 |
Bayer Ag |
Substituierte Aminodicarbonsäurederivate
|
|
US7083970B2
(en)
|
2001-04-19 |
2006-08-01 |
The Scripps Research Institute |
Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs
|
|
AUPR814401A0
(en)
|
2001-10-08 |
2001-11-01 |
Howard Florey Institute Of Experimental Physiology And Medicine |
Human 3 relaxin
|
|
US6908963B2
(en)
|
2001-10-09 |
2005-06-21 |
Nektar Therapeutics Al, Corporation |
Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
|
|
EP2042196B1
(en)
|
2001-10-10 |
2016-07-13 |
ratiopharm GmbH |
Remodelling and glycoconjugation of Granulocyte Colony Stimulating Factor (G-CSF)
|
|
AU2002352524B2
(en)
|
2001-11-07 |
2007-10-04 |
Nektar Therapeutics |
Branched polymers and their conjugates
|
|
US6716821B2
(en)
|
2001-12-21 |
2004-04-06 |
Immunogen Inc. |
Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same
|
|
DE10220570A1
(de)
|
2002-05-08 |
2003-11-20 |
Bayer Ag |
Carbamat-substituierte Pyrazolopyridine
|
|
AU2003240482B2
(en)
|
2002-05-30 |
2009-03-12 |
The Scripps Research Institute |
Copper-catalysed ligation of azides and acetylenes
|
|
ES2324608T3
(es)
|
2002-10-16 |
2009-08-11 |
The Scripps Research Institute |
Incorporacion especifica de sitio de cetoaminoacidos en proteinas.
|
|
MXPA05003978A
(es)
|
2002-10-16 |
2005-06-22 |
Scripps Research Inst |
Sintesis de glicoproteinas.
|
|
WO2004058946A2
(en)
|
2002-12-22 |
2004-07-15 |
The Scripps Research Institute |
Protein arrays
|
|
WO2004094593A2
(en)
|
2003-04-17 |
2004-11-04 |
The Scripps Research Institute |
Expanding the eukaryotic genetic code
|
|
AU2003903124A0
(en)
|
2003-06-20 |
2003-07-10 |
Mark Del Borgo |
Analogues of heteromeric proteins
|
|
US20060160175A1
(en)
|
2003-07-07 |
2006-07-20 |
The Scripps Research Institute |
Compositions of orthogonal leucyl-trna and aminoacyl-trna synthetase pairs and uses thereof
|
|
WO2005019415A2
(en)
|
2003-07-07 |
2005-03-03 |
The Scripps Research Institute |
Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof
|
|
WO2005007624A2
(en)
|
2003-07-07 |
2005-01-27 |
The Scripps Research Institute |
Compositions of orthogonal glutamyl-trna and aminoacyl trna synthetase pairs and uses thereof
|
|
EP1653991A2
(en)
|
2003-08-08 |
2006-05-10 |
Fresenius Kabi Deutschland GmbH |
Conjugates of a polymer and a protein linked by an oxime linking group
|
|
EP1675620B1
(en)
|
2003-10-09 |
2019-05-08 |
Ambrx, Inc. |
Polymer derivatives
|
|
EP2327724A3
(en)
|
2004-02-02 |
2011-07-27 |
Ambrx, Inc. |
Modified human growth hormone polypeptides and their uses
|
|
CA2557782A1
(en)
|
2004-03-17 |
2005-10-06 |
Eli Lilly And Company |
Glycol linked fgf-21 compounds
|
|
WO2005089489A2
(en)
|
2004-03-19 |
2005-09-29 |
Bas Medical, Inc. |
Use of relaxin to increase arterial compliance
|
|
KR101699142B1
(ko)
|
2004-06-18 |
2017-01-23 |
암브룩스, 인코포레이티드 |
신규 항원-결합 폴리펩티드 및 이의 용도
|
|
JP2008507280A
(ja)
|
2004-07-21 |
2008-03-13 |
アンブレツクス・インコーポレイテツド |
非天然コードアミノ酸を用いた生合成ポリペプチド
|
|
GB2438760A
(en)
|
2004-12-22 |
2007-12-05 |
Ambrx Inc |
Methods for expression and purification of recombinant human growth hormone
|
|
US7816320B2
(en)
|
2004-12-22 |
2010-10-19 |
Ambrx, Inc. |
Formulations of human growth hormone comprising a non-naturally encoded amino acid at position 35
|
|
CN102732588B
(zh)
|
2004-12-22 |
2015-01-07 |
Ambrx公司 |
氨酰基-tRNA合成酶的组合物及其用途
|
|
EP1828224B1
(en)
|
2004-12-22 |
2016-04-06 |
Ambrx, Inc. |
Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
|
|
JP2008525473A
(ja)
|
2004-12-22 |
2008-07-17 |
アンブレツクス・インコーポレイテツド |
修飾されたヒト成長ホルモン
|
|
US7883858B2
(en)
|
2005-01-27 |
2011-02-08 |
Institute For Systems Biology |
Methods for identifying and monitoring drug side effects
|
|
US20060264367A1
(en)
|
2005-05-21 |
2006-11-23 |
Howard Florey Institute |
Prevention of fibrosis following cardiac injury
|
|
WO2006133089A2
(en)
|
2005-06-03 |
2006-12-14 |
Ambrx, Inc. |
Improved human interferon molecules and their uses
|
|
JP2008541766A
(ja)
|
2005-06-03 |
2008-11-27 |
アンブレツクス・インコーポレイテツド |
タンパク質中への天然にコードされないアミノ酸の取り込み
|
|
MX2008002149A
(es)
|
2005-08-18 |
2008-04-22 |
Ambrx Inc |
Composiciones de arnt y sus usos.
|
|
AU2006311938A1
(en)
|
2005-11-02 |
2007-05-18 |
Ambrx, Inc. |
Biosynthetic polypeptide fusion inhibitors
|
|
CN104710503B
(zh)
|
2005-11-08 |
2023-04-25 |
Ambrx 公司 |
用于修饰非天然氨基酸和非天然氨基酸多肽的促进剂
|
|
EP1951890A4
(en)
|
2005-11-16 |
2009-06-24 |
Ambrx Inc |
PROCESSES AND COMPOSITIONS WITH NON-NATURAL AMINO ACIDS
|
|
DK1968635T3
(en)
|
2005-12-14 |
2014-12-15 |
Ambrx Inc |
Compositions and Methods of, and uses of non-natural amino acids and polypeptides
|
|
AU2006332809A1
(en)
|
2005-12-30 |
2007-07-12 |
Ambrx, Inc. |
Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
|
|
AU2007215566A1
(en)
|
2006-01-19 |
2007-08-23 |
Ambrx, Inc. |
Non-natural amino acid polypeptides having modulated immunogenicity
|
|
AU2007224019A1
(en)
|
2006-03-03 |
2007-09-13 |
California Institute Of Technology |
Site-specific incorporation of amino acids into molecules
|
|
US7960141B2
(en)
|
2006-03-09 |
2011-06-14 |
The Scripps Research Institute |
Systems for the expression of orthogonal translation components in eubacterial host cells
|
|
MX2009002460A
(es)
|
2006-09-08 |
2009-03-20 |
Ambrx Inc |
Arnt supresor hibrido para celulas de vertebrados.
|
|
CN106008699A
(zh)
|
2006-09-08 |
2016-10-12 |
Ambrx公司 |
经修饰的人类血浆多肽或Fc骨架和其用途
|
|
EP2064316B1
(en)
|
2006-09-08 |
2012-01-25 |
Ambrx, Inc. |
Site specific incorporation of non-natural amino acids by vertebrate cells
|
|
EP2064333B1
(en)
|
2006-09-08 |
2014-02-26 |
Ambrx, Inc. |
Suppressor trna transcription in vertebrate cells
|
|
EP2089425B1
(en)
|
2006-11-10 |
2011-08-17 |
CovX Technologies Ireland Limited |
Anti-angiogenic compounds
|
|
EP2079687A1
(en)
|
2006-12-18 |
2009-07-22 |
Ambrx, Inc. |
Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
|
|
WO2008083346A1
(en)
|
2006-12-28 |
2008-07-10 |
Ambrx, Inc. |
Phenazine and quinoxaline substituted amino acids and polypeptides
|
|
CA2682147C
(en)
|
2007-03-30 |
2017-08-08 |
Ambrx, Inc. |
Modified fgf-21 polypeptides and their uses
|
|
MX2009011870A
(es)
|
2007-05-02 |
2009-11-12 |
Ambrx Inc |
Polipeptidos de interferon beta modificados y usos de los mismos.
|
|
EP2164519A2
(en)
|
2007-06-08 |
2010-03-24 |
Ascendis Pharma AS |
Long-acting polymeric prodrugs of exendin
|
|
CA2707840A1
(en)
|
2007-08-20 |
2009-02-26 |
Allozyne, Inc. |
Amino acid substituted molecules
|
|
WO2009036460A2
(en)
|
2007-09-14 |
2009-03-19 |
Ambrx, Inc. |
Modified human apolipoprotein a-i polypeptides and their uses
|
|
WO2009040562A1
(en)
*
|
2007-09-26 |
2009-04-02 |
Ucb Pharma S.A. |
Dual specificity antibody fusions
|
|
WO2009052435A1
(en)
|
2007-10-19 |
2009-04-23 |
Ambrx, Inc. |
Anti-tnfri polypeptides and their uses
|
|
CA2704246A1
(en)
|
2007-10-30 |
2009-05-07 |
Howard Florey Institute Of Experimental Physiology And Medicine |
Chimeric relaxin polypeptides comprising an a and b chain derived from different relaxin family peptides
|
|
US9150849B2
(en)
|
2007-11-02 |
2015-10-06 |
The Scripps Research Institute |
Directed evolution using proteins comprising unnatural amino acids
|
|
MX2010005317A
(es)
|
2007-11-20 |
2010-06-02 |
Ambrx Inc |
Polipeptidos de insulina modificados y sus usos.
|
|
NZ586947A
(en)
|
2008-02-08 |
2012-11-30 |
Ambrx Inc |
Modified leptin polypeptides and their uses
|
|
WO2010051056A2
(en)
|
2008-03-11 |
2010-05-06 |
Ambrx, Inc. |
ANTI-FcεRI POLYPEPTIDES AND THEIR USES
|
|
US20110015345A1
(en)
|
2008-03-19 |
2011-01-20 |
Ambrx, Inc. |
Modified FGF-23 Polypeptides and Their Uses
|
|
JP2011520902A
(ja)
|
2008-05-16 |
2011-07-21 |
コーセラ，インコーポレーテッド |
創傷の治癒を促進する方法
|
|
CN102036679A
(zh)
|
2008-05-16 |
2011-04-27 |
科尔泰拉公司 |
用松弛素治疗与急性心力衰竭相关的呼吸困难
|
|
JP2011520917A
(ja)
|
2008-05-16 |
2011-07-21 |
コーセラ，インコーポレーテッド |
慢性心不全の治療方法
|
|
WO2010006214A1
(en)
|
2008-07-09 |
2010-01-14 |
Ambrx, Inc. |
Fgf-21 neutralizing antibodies and their uses
|
|
PT2318029T
(pt)
|
2008-07-23 |
2018-01-10 |
Ambrx Inc |
Polipéptidos de g-csf bovino modificados e suas utilizações
|
|
WO2010033220A2
(en)
|
2008-09-19 |
2010-03-25 |
Nektar Therapeutics |
Modified therapeutics peptides, methods of their preparation and use
|
|
PE20110480A1
(es)
|
2008-09-26 |
2011-07-01 |
Ambrx Inc |
Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales
|
|
MX2011003272A
(es)
|
2008-09-26 |
2011-04-28 |
Ambrx Inc |
Polipeptidos de eritropoyetina animal modificados y sus usos.
|
|
JP5090330B2
(ja)
|
2008-12-26 |
2012-12-05 |
Ｋｄｄｉ株式会社 |
画像処理装置、画像処理方法およびプログラム
|
|
WO2010105081A1
(en)
|
2009-03-13 |
2010-09-16 |
Medtronic, Inc. |
Method of treating heart failure
|
|
US8389475B2
(en)
|
2009-08-10 |
2013-03-05 |
The Board Of Trustees Of The Leland Stanford Junior University |
Relaxin analogs
|
|
GR1007010B
(el)
|
2009-10-08 |
2010-10-07 |
Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras), |
Ινσουλινοειδη πεπτιδια
|
|
JP2013515081A
(ja)
|
2009-12-21 |
2013-05-02 |
アンブルックス，インコーポレイテッド |
修飾されているブタのソマトトロピンポリペプチドおよびそれらの使用
|
|
NZ600361A
(en)
|
2009-12-21 |
2014-06-27 |
Ambrx Inc |
Modified bovine somatotropin polypeptides and their uses
|
|
WO2011079293A1
(en)
|
2009-12-23 |
2011-06-30 |
Ambrx, Inc |
Tumor necrosis factor-related apoptosis inducing ligand polypeptides and their uses
|
|
US20110243943A1
(en)
|
2010-04-02 |
2011-10-06 |
Athena Discovery, Inc. |
Treatment using relaxin-fusion proteins with extended in vivo half-lives
|
|
MA34521B1
(fr)
|
2010-08-17 |
2013-09-02 |
Ambrx Inc |
Polypeptides de relaxine modifiés et leurs utilisations
|
|
US9567386B2
(en)
|
2010-08-17 |
2017-02-14 |
Ambrx, Inc. |
Therapeutic uses of modified relaxin polypeptides
|
|
HUE049352T2
(hu)
*
|
2010-12-22 |
2020-09-28 |
Baxalta GmbH |
Anyagok és módszerek egy vízoldható zsírsavszármazéknak egy fehérjéhez való konjugálására
|
|
KR102356286B1
(ko)
|
2011-05-27 |
2022-02-08 |
암브룩스, 인코포레이티드 |
비-천연 아미노산 연결된 돌라스타틴 유도체를 함유하는 조성물, 이를 수반하는 방법, 및 용도
|
|
KR20140037105A
(ko)
|
2011-05-27 |
2014-03-26 |
암브룩스, 인코포레이티드 |
비-천연 아미노산 연결된 돌라스타틴 유도체를 함유하는 조성물, 이를 수반하는 방법, 및 용도
|
|
EP2726502A1
(en)
|
2011-07-01 |
2014-05-07 |
Bayer Intellectual Property GmbH |
Relaxin fusion polypeptides and uses thereof
|
|
JP2014529293A
(ja)
|
2011-07-08 |
2014-11-06 |
バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ |
レラキシンを放出する融合タンパク質およびその使用
|
|
WO2013068874A1
(en)
|
2011-11-11 |
2013-05-16 |
Pfizer Inc. |
Antibody-drug conjugates
|
|
HK1205747A1
(en)
|
2012-02-29 |
2015-12-24 |
Ambrx, Inc. |
Modified adiponectin polypeptides and their uses
|
|
EP2819702A4
(en)
|
2012-02-29 |
2015-05-20 |
Ambrx Inc |
NOVEL PRODRUGS WITH MOLECULE COMPOSITIONS AND ITS USES
|
|
WO2013130917A1
(en)
|
2012-02-29 |
2013-09-06 |
Ambrx, Inc. |
Interleukin-3 polypeptide conjugates their uses
|
|
CN104245722A
(zh)
|
2012-02-29 |
2014-12-24 |
Ambrx公司 |
白细胞介素-10多肽结合物和其用途
|
|
US10800856B2
(en)
|
2012-06-07 |
2020-10-13 |
Ambrx, Inc. |
Prostate-specific membrane antigen antibody drug conjugates
|
|
KR20150023690A
(ko)
*
|
2012-06-14 |
2015-03-05 |
사노피 |
엑센딘-4 펩타이드 유사체
|
|
JP2015521602A
(ja)
|
2012-06-14 |
2015-07-30 |
アンブルックス, インコーポレイテッドAmbrx, Inc. |
核受容体リガンドポリペプチドに対して複合化されている抗ｐｓｍａ抗体
|
|
SG11201408494UA
(en)
|
2012-06-19 |
2015-02-27 |
Ambrx Inc |
Anti-cd70 antibody drug conjugates
|
|
WO2014059174A1
(en)
|
2012-10-10 |
2014-04-17 |
University Of Pittsburgh - Of The Commonwealth System Of Higher Education |
Use of relaxin to treat atrial fibrillation
|
|
AR094147A1
(es)
|
2012-12-27 |
2015-07-15 |
Bayer Pharma Aktiengellschaft |
Polipeptidos de fusion con actividad de relaxina y sus usos
|
|
CN105792851B
(zh)
|
2013-09-13 |
2023-10-10 |
斯克利普斯研究所 |
修饰的治疗剂及其组合物
|
|
KR102339240B1
(ko)
|
2013-10-15 |
2021-12-15 |
더 스크립스 리서치 인스티튜트 |
펩타이드 키메라 항원 수용체 t 세포 스위치 및 이의 용도
|
|
EP3057991B8
(en)
|
2013-10-15 |
2019-09-04 |
The Scripps Research Institute |
Chimeric antigen receptor t cell switches and uses thereof
|
|
MX2016005545A
(es)
|
2013-11-07 |
2016-10-03 |
Shanghai hengrui pharmaceutical co ltd |
Analogo de la relaxina humana, composicion farmaceutica del mismo y aplicacion farmaceutica del mismo.
|
|
AU2014364589B2
(en)
|
2013-12-18 |
2020-02-27 |
The California Institute For Biomedical Research |
Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof
|
|
US20150297680A1
(en)
|
2014-04-02 |
2015-10-22 |
University Of Virginia Patent Foundation |
Compositions and methods for increasing protein half-life
|
|
US20170210818A1
(en)
|
2014-06-06 |
2017-07-27 |
The California Institute For Biomedical Research |
Constant region antibody fusion proteins and compositions thereof
|
|
KR20170010893A
(ko)
|
2014-06-06 |
2017-02-01 |
더 캘리포니아 인스티튜트 포 바이오메디칼 리써치 |
아미노 말단 면역글로불린 융합 단백질 및 이의 조성물을 구축하는 방법
|
|
JP6803236B2
(ja)
|
2014-06-10 |
2020-12-23 |
アムジェン インコーポレイテッド |
アペリンポリペプチド
|
|
US10588980B2
(en)
|
2014-06-23 |
2020-03-17 |
Novartis Ag |
Fatty acids and their use in conjugation to biomolecules
|
|
MA41794A
(fr)
|
2015-03-18 |
2018-01-23 |
The California Institute For Biomedical Res |
Agents thérapeutiques modifiés et compositions associées
|
|
LT3359189T
(lt)
|
2015-10-05 |
2021-07-26 |
Fredax Ab |
Humanizuoti anti-psa (5a10) antikūnai
|
|
EP3368556B1
(en)
|
2015-10-28 |
2024-04-10 |
Tufts University |
Novel polypeptides with improved proteolytic stability, and methods of preparing and using same
|
|
KR20170065016A
(ko)
|
2015-12-02 |
2017-06-12 |
한미약품 주식회사 |
지방산 유도체를 이용한 단백질 결합체 및 이의 제조방법
|
|
WO2017116204A1
(ko)
|
2015-12-31 |
2017-07-06 |
한미약품 주식회사 |
글루카곤, glp-1 및 gip 수용체 모두에 활성을 갖는 삼중 활성체
|
|
JP2019523293A
(ja)
|
2016-08-04 |
2019-08-22 |
ハドソン インスティテュート オブ メディカル リサーチ |
処置の方法
|
|
EP3522911B1
(en)
|
2016-10-07 |
2021-12-08 |
Beth Israel Deaconess Medical Center, Inc. |
Compositions comprising relaxin and methods of use thereof
|
|
EP3551230A1
(en)
|
2016-12-08 |
2019-10-16 |
CureVac AG |
Rna for treatment or prophylaxis of a liver disease
|
|
WO2018126084A1
(en)
|
2016-12-30 |
2018-07-05 |
Phaserx, Inc. |
Branched peg molecules and related compositions and methods
|
|
AU2018210157B2
(en)
|
2017-01-18 |
2022-10-06 |
Fred Hutchinson Cancer Center |
Peptide compositions and methods of use thereof for disrupting TEAD interactions
|
|
CN110225924B
(zh)
|
2017-01-25 |
2024-04-02 |
免疫医疗有限公司 |
松弛素融合多肽及其用途
|
|
CN110637027B
(zh)
|
2017-02-08 |
2024-08-30 |
百时美施贵宝公司 |
包含药代动力学增强子的修饰的松弛素多肽及其用途
|
|
EP3579782B1
(en)
|
2017-02-08 |
2024-05-01 |
Brooke Schumm |
Intra-operative radiation therapy capsule with cylindrical shell radiation containment shutter system
|
|
JP2020508323A
(ja)
|
2017-02-23 |
2020-03-19 |
ラクテン メディカル インコーポレイテッド |
光免疫療法のための治療用組成物および関連する方法
|
|
WO2018160876A1
(en)
|
2017-03-02 |
2018-09-07 |
The Regents Of The University Of California |
In situ lipid synthesis for protein reconstitution
|
|
JOP20190245A1
(ar)
|
2017-04-20 |
2019-10-15 |
Novartis Ag |
أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط
|
|
US20180371046A1
(en)
|
2017-05-01 |
2018-12-27 |
University Of Pittsburgh - Of The Commonwealth System Of Higher Education |
Therapy for Lower Urinary Tract Dysfunctions
|
|
EP3625253A4
(en)
|
2017-05-16 |
2021-03-24 |
Scalmibio, Inc. |
ACTIVABLE ANTIBODIES AND THEIR METHODS OF USE
|
|
TW201934572A
(zh)
|
2018-01-31 |
2019-09-01 |
法商賽諾菲公司 |
經修飾之鬆弛素ｂ鏈胜肽及其治療用途
|
|
MA52994A
(fr)
|
2018-01-31 |
2021-05-05 |
Sanofi Sa |
Peptides à chaîne b de relaxine lipidés modifiés et leur utilisation thérapeutique
|
|
WO2019149781A1
(en)
|
2018-01-31 |
2019-08-08 |
Sanofi |
Modified lipidated relaxin b chain peptides and their therapeutic use
|