KR102670432B1 - 약동학적 인핸서를 포함하는 변형된 렐락신 폴리펩티드 및 그의 용도 - Google Patents

약동학적 인핸서를 포함하는 변형된 렐락신 폴리펩티드 및 그의 용도 Download PDF

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KR102670432B1
KR102670432B1 KR1020197025964A KR20197025964A KR102670432B1 KR 102670432 B1 KR102670432 B1 KR 102670432B1 KR 1020197025964 A KR1020197025964 A KR 1020197025964A KR 20197025964 A KR20197025964 A KR 20197025964A KR 102670432 B1 KR102670432 B1 KR 102670432B1
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relaxin
seq
polypeptide
delete delete
amino acid
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KR20190115049A (ko
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진 엠. 두보우치크
올라푸르 에스. 구드문드손
샤오준 한
알. 마이클 로렌스
다사 리포브세크
코트 에스. 마드센
클라우디오 마펠리
폴 이. 모린
마이클 씨. 마이어스
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브리스톨-마이어스 스큅 컴퍼니
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/64—Relaxins
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2221—Relaxins
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    • A61P3/06—Antihyperlipidemics
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent

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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
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KR1020197025964A 2017-02-08 2018-02-08 약동학적 인핸서를 포함하는 변형된 렐락신 폴리펩티드 및 그의 용도 Active KR102670432B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762456161P 2017-02-08 2017-02-08
US62/456,161 2017-02-08
US201862627411P 2018-02-07 2018-02-07
US62/627,411 2018-02-07
PCT/US2018/017436 WO2018148419A1 (en) 2017-02-08 2018-02-08 Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof

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KR20190115049A KR20190115049A (ko) 2019-10-10
KR102670432B1 true KR102670432B1 (ko) 2024-05-28

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US (5) US10266578B2 (https=)
EP (1) EP3580232B1 (https=)
JP (1) JP7372837B2 (https=)
KR (1) KR102670432B1 (https=)
CN (1) CN110637027B (https=)
AU (2) AU2018219283B2 (https=)
BR (1) BR112019016139A2 (https=)
CA (1) CA3052639A1 (https=)
CL (1) CL2019002132A1 (https=)
CO (1) CO2019009587A2 (https=)
ES (1) ES2963839T3 (https=)
IL (1) IL268421A (https=)
MX (1) MX2019008449A (https=)
MY (1) MY193457A (https=)
PE (1) PE20191716A1 (https=)
SG (2) SG10201912034UA (https=)
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WO (1) WO2018148419A1 (https=)

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TWI844709B (zh) 2019-07-31 2024-06-11 美商美國禮來大藥廠 鬆弛素(relaxin)類似物及其使用方法
GB201916884D0 (en) * 2019-11-20 2020-01-01 Evox Therapeutics Ltd Nanoparticle-like delivery system
IL297951A (en) * 2020-05-08 2023-01-01 Harvard College Engineered relaxins and methods of use thereof
JP2023526512A (ja) 2020-05-22 2023-06-21 トラスティーズ オブ ボストン ユニバーシティ 線維化疾患を処置するための方法および組成物
WO2021247475A1 (en) * 2020-06-02 2021-12-09 Trustees Of Boston University Production of soluble relaxin and relaxin analogs
CN114075276A (zh) * 2020-08-17 2022-02-22 成都奥达生物科技有限公司 一种长效松弛素2类似物
KR102801198B1 (ko) * 2021-06-28 2025-04-30 (주) 넥셀 특발성 폐섬유증 예방 또는 치료용 폴리펩타이드 및 이를 포함하는 약학 조성물
US20240400638A1 (en) * 2021-08-23 2024-12-05 Guido MAGNI Combination of relaxin and vasopressin analogues for treatment of renal disorders or conditions
CN113699124B (zh) * 2021-09-08 2022-04-12 北京大学 一种含非天然氨基酸蛋白的制备方法
WO2023086913A2 (en) 2021-11-11 2023-05-19 Tectonic Therapeutic, Inc. Relaxin-2 fusion protein analogs and methods of using same
CN115717130B (zh) * 2022-09-02 2024-10-15 凯莱英医药集团（天津）股份有限公司 氨酰-tRNA合酶突变体及烯基酪氨酰-tRNA的制备方法
KR20260035823A (ko) * 2023-05-18 2026-03-13 테크토닉 오퍼레이팅 컴퍼니 인코포레이티드 렐락신-2 융합 단백질 유사체 및 이를 사용하는 방법

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