|
CH653021A5
(fr)
|
1981-04-24 |
1985-12-13 |
Delalande Sa |
Derives piperidino, piperazino et homopiperazino, n-substitues par un groupe heterocyclique aromatique, leur procede de preparation et composition therapeutique les contenant.
|
|
IL73534A
(en)
|
1983-11-18 |
1990-12-23 |
Riker Laboratories Inc |
1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds
|
|
WO1988007089A1
(en)
|
1987-03-18 |
1988-09-22 |
Medical Research Council |
Altered antibodies
|
|
WO1990014844A2
(en)
|
1989-06-06 |
1990-12-13 |
Neorx Corporation |
Sugars as cleavable linkers for the delivery and release of agents in native form
|
|
US5650150A
(en)
|
1990-11-09 |
1997-07-22 |
Gillies; Stephen D. |
Recombinant antibody cytokine fusion proteins
|
|
US5389640A
(en)
|
1991-03-01 |
1995-02-14 |
Minnesota Mining And Manufacturing Company |
1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines
|
|
ES2237750T3
(es)
*
|
1993-12-09 |
2005-08-01 |
Centro De Inmunologia Molecular |
Vacuna que comprende factor de crecimiento epidermico autologo humano y su uso.
|
|
EP0894797A4
(en)
|
1997-01-09 |
2001-08-16 |
Terumo Corp |
NEW AMID DERIVATIVES AND INTERMEDIATES ON YOUR SYNTHESIS
|
|
ZA9811162B
(en)
*
|
1997-12-12 |
2000-06-07 |
Genentech Inc |
Treatment with anti-ERBB2 antibodies.
|
|
US20090208418A1
(en)
*
|
2005-04-29 |
2009-08-20 |
Innexus Biotechnology Internaltional Ltd. |
Superantibody synthesis and use in detection, prevention and treatment of disease
|
|
US20020155108A1
(en)
|
1998-05-04 |
2002-10-24 |
Biocrystal, Ltd. |
Method for ex vivo loading of antigen presenting cells with antigen, and a vaccine comprising the loaded cells
|
|
FI107193B
(fi)
|
1999-06-03 |
2001-06-15 |
Rouvari Oy R |
Mittausanturi
|
|
SE9902036L
(sv)
|
1999-06-03 |
2000-07-31 |
Jan Folke Wallenius |
Förfarande och anordning för att under färd bestämma friktionen mellan vägbanan och ett fordons hjul
|
|
JP2003501643A
(ja)
|
1999-06-04 |
2003-01-14 |
チェオン, チュン, エドモンド チョイ, |
不浸透面をテストする装置及び方法
|
|
US6451810B1
(en)
|
1999-06-10 |
2002-09-17 |
3M Innovative Properties Company |
Amide substituted imidazoquinolines
|
|
US6331539B1
(en)
|
1999-06-10 |
2001-12-18 |
3M Innovative Properties Company |
Sulfonamide and sulfamide substituted imidazoquinolines
|
|
US6541485B1
(en)
|
1999-06-10 |
2003-04-01 |
3M Innovative Properties Company |
Urea substituted imidazoquinolines
|
|
US6573273B1
(en)
|
1999-06-10 |
2003-06-03 |
3M Innovative Properties Company |
Urea substituted imidazoquinolines
|
|
US6756382B2
(en)
|
1999-06-10 |
2004-06-29 |
3M Innovative Properties Company |
Amide substituted imidazoquinolines
|
|
JP2003531149A
(ja)
|
2000-04-13 |
2003-10-21 |
ザ・ロツクフエラー・ユニバーシテイ |
抗体由来の免疫応答の増強
|
|
SI1296714T1
(sl)
|
2000-06-22 |
2010-01-29 |
S For Entpr University Of Iowa |
Kombinacija CpG-ja in protiteles, usmerjenih proti CD19, CD20, CD22 ali CD40 za zdravljenje ali preprečevanje raka
|
|
CN1549726A
(zh)
*
|
2000-07-31 |
2004-11-24 |
耶鲁大学 |
先天性免疫系统指导的疫苗
|
|
MXPA03003632A
(es)
|
2000-10-24 |
2003-09-10 |
Immunex Corp |
Metodo para tratamiento de tumores usando terapia de combinacion.
|
|
CA2598144A1
(en)
|
2000-12-08 |
2006-08-31 |
3M Innovative Properties Company |
Compositions and methods for targeted delivery of immune response modifiers
|
|
CA2430206A1
(en)
|
2000-12-08 |
2002-06-13 |
3M Innovative Properties Company |
Screening method for identifying compounds that selectively induce interferon alpha
|
|
ES2318615T3
(es)
|
2001-11-16 |
2009-05-01 |
Coley Pharmaceutical Group, Inc. |
N-(4-(4-amino-2-etil-1h-imidazo(4,5-c)quinolin-1-il)butil)metanosulfonamida, una composicion farmaceutica que la comprende y uso de la misma.
|
|
NZ532769A
(en)
|
2001-11-29 |
2005-12-23 |
3M Innovative Properties Co |
Pharmaceutical formulations comprising an immune response modifier
|
|
US6677349B1
(en)
|
2001-12-21 |
2004-01-13 |
3M Innovative Properties Company |
Sulfonamide and sulfamide substituted imidazoquinolines
|
|
WO2003074566A2
(en)
|
2002-03-01 |
2003-09-12 |
Immunomedics, Inc. |
Rs7 antibodies
|
|
ES2355819T3
(es)
|
2002-08-15 |
2011-03-31 |
3M Innovative Properties Company |
Composiciones inmunoestimuladoras y métodos para estimular una respuesta inmune.
|
|
US20040101909A1
(en)
|
2002-08-20 |
2004-05-27 |
Hema-Quebec, 2535 Boul. Laurier, Ste-Foy, Quebec, Canada G1V 4M3 |
Purification of polyreactive autoantibodies and uses thereof
|
|
US6924154B2
(en)
|
2002-08-20 |
2005-08-02 |
Quest Diagnostics Investments Incorporated |
Hydrophilic chemilumescent acridinium labeling reagents
|
|
AU2003299082A1
(en)
|
2002-09-26 |
2004-04-19 |
3M Innovative Properties Company |
1h-imidazo dimers
|
|
AU2003287324A1
(en)
|
2002-12-11 |
2004-06-30 |
3M Innovative Properties Company |
Gene expression systems and recombinant cell lines
|
|
AU2003287316A1
(en)
|
2002-12-11 |
2004-06-30 |
3M Innovative Properties Company |
Assays relating to toll-like receptor activity
|
|
NZ540826A
(en)
|
2002-12-20 |
2008-07-31 |
3M Innovative Properties Co |
Aryl / hetaryl substituted imidazoquinolines
|
|
WO2004060319A2
(en)
|
2002-12-30 |
2004-07-22 |
3M Innovative Properties Company |
Immunostimulatory combinations
|
|
EP1592302A4
(en)
|
2003-02-13 |
2007-04-25 |
3M Innovative Properties Co |
METHODS AND COMPOSITIONS ASSOCIATED WITH IMMUNE RESPONSE MODIFIER COMPOUNDS AND TOLL-LIKE RECEPTOR 8
|
|
US7485432B2
(en)
|
2003-02-27 |
2009-02-03 |
3M Innovative Properties Company |
Selective modulation of TLR-mediated biological activity
|
|
JP2006523452A
(ja)
|
2003-03-25 |
2006-10-19 |
スリーエム イノベイティブ プロパティズ カンパニー |
共通のToll様受容体を通じて媒介される細胞活性の選択的活性化
|
|
AU2004252409A1
(en)
|
2003-04-10 |
2005-01-06 |
3M Innovative Properties Company |
Methods and compositions for enhancing immune response
|
|
AU2004244962A1
(en)
|
2003-04-10 |
2004-12-16 |
3M Innovative Properties Company |
Delivery of immune response modifier compounds using metal-containing particulate support materials
|
|
US20040265351A1
(en)
|
2003-04-10 |
2004-12-30 |
Miller Richard L. |
Methods and compositions for enhancing immune response
|
|
US20040214851A1
(en)
|
2003-04-28 |
2004-10-28 |
3M Innovative Properties Company |
Compositions and methods for induction of opioid receptors
|
|
US8088387B2
(en)
|
2003-10-10 |
2012-01-03 |
Immunogen Inc. |
Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
|
|
MY157827A
(en)
|
2003-06-27 |
2016-07-29 |
3M Innovative Properties Co |
Sulfonamide substituted imidazoquinolines
|
|
JP2007501251A
(ja)
|
2003-08-05 |
2007-01-25 |
スリーエム イノベイティブ プロパティズ カンパニー |
免疫応答調節剤化合物を使用する感染予防
|
|
US7799800B2
(en)
|
2003-08-14 |
2010-09-21 |
3M Innovative Properties Company |
Lipid-modified immune response modifiers
|
|
US8198020B2
(en)
|
2003-08-22 |
2012-06-12 |
Potentia Pharmaceuticals, Inc. |
Compositions and methods for enhancing phagocytosis or phagocyte activity
|
|
NZ545412A
(en)
|
2003-08-27 |
2008-12-24 |
Coley Pharm Group Inc |
Aryloxy and arylalkyleneoxy substituted imidazoquinolines
|
|
US20150071948A1
(en)
|
2003-09-26 |
2015-03-12 |
Gregory Alan Lazar |
Novel immunoglobulin variants
|
|
US8277810B2
(en)
|
2003-11-04 |
2012-10-02 |
Novartis Vaccines & Diagnostics, Inc. |
Antagonist anti-CD40 antibodies
|
|
CA2547085A1
(en)
|
2003-11-25 |
2005-06-09 |
3M Innovative Properties Company |
Hydroxylamine and oxime substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines
|
|
US20050158325A1
(en)
|
2003-12-30 |
2005-07-21 |
3M Innovative Properties Company |
Immunomodulatory combinations
|
|
US20060018911A1
(en)
|
2004-01-12 |
2006-01-26 |
Dana Ault-Riche |
Design of therapeutics and therapeutics
|
|
CA2559863A1
(en)
|
2004-03-24 |
2005-10-13 |
3M Innovative Properties Company |
Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
|
|
US20070166384A1
(en)
|
2004-04-09 |
2007-07-19 |
Zarraga Isidro Angelo E |
Methods , composition and preparations for delivery of immune response modifiers
|
|
BRPI0510716A
(pt)
|
2004-05-05 |
2007-11-20 |
Merrimack Pharmaceuticals Inc |
uso de um agente de ligação bi-especìfico, agente de ligação bi-especìfico, composição de um agente de ligação bi-especìfico, e, kit
|
|
WO2005123080A2
(en)
|
2004-06-15 |
2005-12-29 |
3M Innovative Properties Company |
Nitrogen-containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
|
|
AU2005283085B2
(en)
|
2004-06-18 |
2012-06-21 |
3M Innovative Properties Company |
Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines
|
|
NZ553500A
(en)
|
2004-09-23 |
2009-11-27 |
Genentech Inc Genentech Inc |
Cysteine engineered antibodies and conjugates withCysteine engineered antibodies and conjugates with a free cysteine amino acid in the heavy chain a free cysteine amino acid in the heavy chain
|
|
US20060135459A1
(en)
|
2004-11-09 |
2006-06-22 |
Epstein Alan L |
Targeted innate immunity
|
|
US8435800B2
(en)
|
2004-11-22 |
2013-05-07 |
Biosight Ltd. |
Activated labeling reagents and methods for preparing and using the same
|
|
US7943609B2
(en)
|
2004-12-30 |
2011-05-17 |
3M Innovative Proprerties Company |
Chiral fused [1,2]imidazo[4,5-C] ring compounds
|
|
EP1835935A4
(en)
|
2004-12-30 |
2009-06-17 |
Univ Rockefeller |
COMPOSITIONS AND METHODS FOR ENHANCING THE MATURATION AND FUNCTION OF DENDRITIC CELLS
|
|
AU2006210392A1
(en)
|
2005-02-04 |
2006-08-10 |
Coley Pharmaceutical Group, Inc. |
Aqueous gel formulations containing immune response modifiers
|
|
WO2006091394A2
(en)
|
2005-02-11 |
2006-08-31 |
Coley Pharmaceutical Group, Inc. |
Substituted imidazoquinolines and imidazonaphthyridines
|
|
NZ565953A
(en)
|
2005-07-27 |
2012-01-12 |
Univ Florida |
Small compounds that correct protein misfolding and uses thereof
|
|
US8354249B2
(en)
|
2005-08-11 |
2013-01-15 |
Omrix Biopharmaceuticals Ltd. |
Intravenous immunoglobulin composition
|
|
ES2577514T3
(es)
|
2005-08-22 |
2016-07-15 |
The Regents Of The University Of California |
Antagonistas de TLR
|
|
PL1945665T3
(pl)
|
2005-10-21 |
2012-02-29 |
Genzyme Corp |
Leki oparte na przeciwciałach z ulepszoną aktywnością adcc
|
|
WO2007055916A2
(en)
|
2005-11-07 |
2007-05-18 |
The Rockefeller University |
Reagents, methods and systems for selecting a cytotoxic antibody or variant thereof
|
|
WO2007100634A2
(en)
|
2006-02-22 |
2007-09-07 |
3M Innovative Properties Company |
Immune response modifier conjugates
|
|
WO2007103048A2
(en)
|
2006-03-01 |
2007-09-13 |
Regents Of The University Of Colorado |
Tlr agonist (flagellin)/cd40 agonist/antigen protein and dna conjugates and use thereof for inducing synergistic enhancement in immunity
|
|
WO2007130493A2
(en)
|
2006-05-03 |
2007-11-15 |
Regents Of The University Of Colorado |
Cd40 agonist antibody/type1 interferon synergistic adjuvant combination, conjugates containing and use thereof as a therapeutic to enhance cellular immunity
|
|
US20080031887A1
(en)
|
2006-06-30 |
2008-02-07 |
Joseph Lustgarten |
Conjugates for inducing targeted immune responses and methods of making and using same
|
|
EP2037957A4
(en)
|
2006-06-30 |
2010-09-08 |
Baylor Res Inst |
USING GM-CSF AND INTERFERON ALPHA PRODUCED AND DENDRITIC CELLS LOADED WITH HEAT-TREATED AND DEFECTED CANCER CELLS
|
|
GB0614098D0
(en)
|
2006-07-15 |
2006-08-23 |
Mnl Pharma Ltd |
Immune response variegation with imino sugars
|
|
GB0620894D0
(en)
|
2006-10-20 |
2006-11-29 |
Univ Southampton |
Human immune therapies using a CD27 agonist alone or in combination with other immune modulators
|
|
US20080241139A1
(en)
|
2006-10-31 |
2008-10-02 |
Regents Of The University Of Colorado |
Adjuvant combinations comprising a microbial tlr agonist, a cd40 or 4-1bb agonist, and optionally an antigen and the use thereof for inducing a synergistic enhancement in cellular immunity
|
|
US20080149123A1
(en)
|
2006-12-22 |
2008-06-26 |
Mckay William D |
Particulate material dispensing hairbrush with combination bristles
|
|
EP2129692A4
(en)
|
2007-02-23 |
2010-12-15 |
Baylor Res Inst |
ACTIVATION OF CELLS WITH HUMAN ANTIGENES BY CLEC-6
|
|
BRPI0807617A2
(pt)
|
2007-02-23 |
2014-07-22 |
Baylor Research Institute |
Aplicações terapêuticas de ativação de antígeno humano presente em células através de dectin-1.
|
|
CA2676049C
(en)
|
2007-03-01 |
2018-04-10 |
Symphogen A/S |
Recombinant anti-epidermal growth factor receptor antibody compositions
|
|
CA2691089A1
(en)
|
2007-06-15 |
2008-12-24 |
Immurx, Inc. |
Use of tlr agonists and/or type 1 interferons to alleviate toxicity of tnf-r agonist therapeutic regimens
|
|
JP2010535248A
(ja)
|
2007-07-31 |
2010-11-18 |
ザ ジョンズ ホプキンス ユニバーシティー |
腫瘍性障害または感染症の免疫学的予防または免疫療法のためのポリペプチド−核酸複合体
|
|
WO2009059309A2
(en)
*
|
2007-11-01 |
2009-05-07 |
Panacea Pharmaceuticals, Inc. |
Furin-cleavable peptide linkers for drug-ligand conjugates
|
|
US20100098657A1
(en)
|
2007-12-27 |
2010-04-22 |
Schafer Peter H |
Method of Treating Cancer with Immunomodulatory Compounds and IgG
|
|
CA2713137C
(en)
|
2008-01-25 |
2017-10-24 |
Hadasit Medical Research Services And Development Ltd. |
Targeting of innate immune response to tumor site
|
|
AU2009231991B2
(en)
|
2008-04-02 |
2014-09-25 |
Macrogenics, Inc. |
HER2/neu-specific antibodies and methods of using same
|
|
CN104524590B
(zh)
|
2008-04-30 |
2019-06-21 |
伊缪诺金公司 |
交联剂和它们的用途
|
|
US20090325315A1
(en)
|
2008-06-30 |
2009-12-31 |
Arkray, Inc. |
Detection method of target substance, detection reagent used for the same, and the uses thereof
|
|
BRPI0911926A2
(pt)
|
2008-08-05 |
2020-08-18 |
Toray Industries, Inc |
composições farmacêuticas, anticorpos e usos de um anticorpo ou um fragmento do mesmo.
|
|
US20100129383A1
(en)
|
2008-10-03 |
2010-05-27 |
The Governors Of The University Of Alberta |
Bifunctional fusion molecules for the delivery of antigens to professional antigen-presenting cells
|
|
US20100150942A1
(en)
|
2008-12-03 |
2010-06-17 |
Cantor Thomas L |
Affinity purified human polyclonal antibodies and methods of making and using them
|
|
WO2010121093A2
(en)
|
2009-04-17 |
2010-10-21 |
Lpath, Inc. |
Humanized antibody compositions and methods for binding lysophosphatidic acid
|
|
WO2010132622A2
(en)
|
2009-05-14 |
2010-11-18 |
The Regents Of The University Of California |
Anticd20-cpg conjugates and methods of treating b cell malignancies
|
|
CN102781933B
(zh)
|
2009-08-18 |
2016-01-20 |
文蒂雷克斯药品公司 |
作为toll样受体调节剂的取代的苯并氮杂*
|
|
US8691809B2
(en)
|
2009-08-18 |
2014-04-08 |
Ventirx Pharmaceuticals, Inc. |
Substituted benzoazepines as toll-like receptor modulators
|
|
CA2809819A1
(en)
|
2009-09-09 |
2011-03-17 |
Centrose, Llc |
Extracellular targeted drug conjugates
|
|
JP5885664B2
(ja)
|
2009-09-25 |
2016-03-15 |
ゾーマ テクノロジー リミテッド |
スクリーニング法
|
|
GB0917054D0
(en)
|
2009-09-29 |
2009-11-11 |
Cytoguide As |
Agents, uses and methods
|
|
GB0917044D0
(en)
|
2009-09-29 |
2009-11-18 |
Cytoguide As |
Agents, uses and methods
|
|
US8518405B2
(en)
|
2009-10-08 |
2013-08-27 |
The University Of North Carolina At Charlotte |
Tumor specific antibodies and uses therefor
|
|
RU2567657C2
(ru)
|
2010-02-04 |
2015-11-10 |
Торэй Индастриз, Инк. |
Фармацевтическая композиция для лечения и/или профилактики рака
|
|
US8828398B2
(en)
|
2010-02-04 |
2014-09-09 |
Toray Industries, Inc. |
Pharmaceutical composition for treating and/or preventing cancer
|
|
PT2532364T
(pt)
|
2010-02-04 |
2016-07-28 |
Toray Industries |
Composição farmacêutica que compreende anticorpos anti caprin-1 para o tratamento e/ou a prevenção de cancro
|
|
CN102821789B
(zh)
|
2010-02-04 |
2016-03-02 |
东丽株式会社 |
癌的治疗和/或预防用药物组合物
|
|
ES2583627T3
(es)
|
2010-02-04 |
2016-09-21 |
Toray Industries, Inc. |
Composición farmacéutica para el tratamiento y/o la prevención del cáncer
|
|
US9203872B2
(en)
|
2010-02-19 |
2015-12-01 |
Microsoft Technology Licensing, Llc |
Distributed connectivity policy enforcement with ICE
|
|
GB201003293D0
(en)
|
2010-02-26 |
2010-04-14 |
Adjuvantix Ltd |
Cancer vaccine
|
|
PL2542590T5
(pl)
|
2010-03-05 |
2020-08-10 |
The Johns Hopkins University |
Kompozycje i sposoby dla ukierunkowanych immunomodulatorowych przeciwciał i białek fuzyjnych
|
|
NZ602892A
(en)
|
2010-04-13 |
2014-08-29 |
Celldex Therapeutics Inc |
Antibodies that bind human cd27 and uses thereof
|
|
US20120213771A1
(en)
|
2010-04-13 |
2012-08-23 |
Celldex Therapeutics Inc. |
Antibodies that bind human cd27 and uses thereof
|
|
KR20130036246A
(ko)
|
2010-05-07 |
2013-04-11 |
베일러 리서치 인스티튜트 |
사람 cd8+ t 세포의 수지상 세포 면역수용체(dcir)-매개 교차프라이밍
|
|
KR101848225B1
(ko)
|
2010-05-14 |
2018-04-12 |
애브비 인코포레이티드 |
Il-1 결합 단백질
|
|
US9000130B2
(en)
|
2010-06-08 |
2015-04-07 |
Genentech, Inc. |
Cysteine engineered antibodies and conjugates
|
|
JPWO2011155579A1
(ja)
|
2010-06-10 |
2013-08-15 |
北海道公立大学法人 札幌医科大学 |
抗Trop−2抗体
|
|
TW201217527A
(en)
|
2010-07-09 |
2012-05-01 |
Biogen Idec Hemophilia Inc |
Processable single chain molecules and polypeptides made using same
|
|
CA2804185C
(en)
|
2010-07-12 |
2017-03-21 |
Covx Technologies Ireland Limited |
Multifunctional antibody conjugates
|
|
US20120039916A1
(en)
|
2010-08-13 |
2012-02-16 |
Baylor Research Institute |
Novel vaccine adjuvants based on targeting adjuvants to antibodies directly to antigen-presenting cells
|
|
NZ608673A
(en)
|
2010-10-01 |
2015-04-24 |
Univ Pennsylvania |
Therapeutic use of a tlr agonist and combination therapy
|
|
US20120328605A1
(en)
|
2010-10-27 |
2012-12-27 |
Daniel Larocque |
Compositions and uses
|
|
JP6014596B2
(ja)
|
2010-11-09 |
2016-10-25 |
メディミューン,エルエルシー |
均一コンジュゲーションのための抗体足場
|
|
US20120171229A1
(en)
|
2010-12-30 |
2012-07-05 |
Selecta Biosciences, Inc. |
Synthetic nanocarriers with reactive groups that release biologically active agents
|
|
US20120231023A1
(en)
|
2011-03-08 |
2012-09-13 |
Baylor Research Institute |
Novel Vaccine Adjuvants Based on Targeting Adjuvants to Antibodies Directly to Antigen-Presenting Cells
|
|
TW201300418A
(zh)
|
2011-03-25 |
2013-01-01 |
Baylor Res Inst |
用於抗c型肝炎病毒免疫之組合物及方法
|
|
PT2699264T
(pt)
|
2011-04-20 |
2018-05-23 |
Medimmune Llc |
Anticorpos e outras moléculas que ligam b7-h1 e pd-1
|
|
US8728486B2
(en)
|
2011-05-18 |
2014-05-20 |
University Of Kansas |
Toll-like receptor-7 and -8 modulatory 1H imidazoquinoline derived compounds
|
|
WO2012166555A1
(en)
|
2011-05-27 |
2012-12-06 |
Nektar Therapeutics |
Water - soluble polymer - linked binding moiety and drug compounds
|
|
WO2012167088A1
(en)
|
2011-06-03 |
2012-12-06 |
3M Innovative Properties Company |
Heterobifunctional linkers with polyethylene glycol segments and immune response modifier conjugates made therefrom
|
|
CN103582640B
(zh)
|
2011-06-03 |
2015-11-25 |
3M创新有限公司 |
肼基1h-咪唑并喹啉-4-胺以及由其制成的缀合物
|
|
EP2718457A4
(en)
|
2011-06-06 |
2014-12-24 |
Immungene Inc |
GENETICALLY MODIFIED FUSION MOLECULES LIGAND TNFSF-ANTIBODY ELEMENT
|
|
KR102041832B1
(ko)
|
2011-08-04 |
2019-11-08 |
도레이 카부시키가이샤 |
췌장암의 치료 및/또는 예방용 의약 조성물
|
|
CA2844040C
(en)
|
2011-08-04 |
2019-05-07 |
Toray Industries, Inc. |
Pharmaceutical composition for treatment and/or prophylaxis of cancer
|
|
WO2013018894A1
(ja)
|
2011-08-04 |
2013-02-07 |
東レ株式会社 |
癌の治療及び/又は予防用医薬組成物
|
|
JP6065591B2
(ja)
|
2011-08-04 |
2017-01-25 |
東レ株式会社 |
癌の治療及び/又は予防用医薬組成物
|
|
BR112014002616B1
(pt)
|
2011-08-04 |
2022-01-18 |
Toray Industries, Inc |
Método para detectar câncer pancreático
|
|
JP6065592B2
(ja)
|
2011-08-04 |
2017-01-25 |
東レ株式会社 |
癌の治療及び/又は予防用医薬組成物
|
|
BR112014002621B1
(pt)
|
2011-08-04 |
2022-09-20 |
Toray Industries, Inc |
Anticorpo, ou seu fragmento, composição farmacêutica, uso de um anticorpo e uso de uma composição farmacêutica
|
|
GB201113570D0
(en)
|
2011-08-05 |
2011-09-21 |
Glaxosmithkline Biolog Sa |
Vaccine
|
|
US9676854B2
(en)
|
2011-08-15 |
2017-06-13 |
Medimmune, Llc |
Anti-B7-H4 antibodies and their uses
|
|
CA2847204A1
(en)
|
2011-09-01 |
2013-03-07 |
Novartis Ag |
Adjuvanted formulations of staphylococcus aureus antigens
|
|
WO2013043647A1
(en)
|
2011-09-19 |
2013-03-28 |
The Johns Hopkins University |
Cancer immunotherapy
|
|
NL2007536C2
(en)
|
2011-10-05 |
2013-04-08 |
Academisch Ziekenhuis Leiden Lumc |
Adjuvant compound.
|
|
US20130108619A1
(en)
|
2011-11-02 |
2013-05-02 |
Isaac Melamed |
Intravenous immunoglobulin processing, diagnostic, and treatment systems and methods
|
|
JP2014532799A
(ja)
|
2011-11-09 |
2014-12-08 |
アセンド・バイオファーマシューティカルズ・リミテッド |
免疫調節結合体
|
|
CN104053672A
(zh)
|
2011-11-11 |
2014-09-17 |
瑞纳神经科学公司 |
Trop-2特异性抗体及其用途
|
|
CA2859755C
(en)
|
2011-12-23 |
2021-04-20 |
Pfizer Inc. |
Engineered antibody constant regions for site-specific conjugation and methods and uses therefor
|
|
EP2802355B1
(en)
|
2012-01-09 |
2018-09-05 |
CovX Technologies Ireland Limited |
Mutant antibodies and conjugation thereof
|
|
CA2860579A1
(en)
|
2012-01-10 |
2013-07-18 |
Biogen Idec Ma Inc. |
Enhancement of transport of therapeutic molecules across the blood brain barrier
|
|
US20130177574A1
(en)
|
2012-01-11 |
2013-07-11 |
Paul I. Terasaki Foundation Laboratory |
ANTI-HLA CLASS-Ib ANTIBODIES MIMIC IMMUNOREACTIVITY AND IMMUNOMODULATORY FUNCTIONS OF INTRAVENOUS IMMUNOGLOBULIN (IVIg) USEFUL AS THERAPEUTIC IVIg MIMETICS AND METHODS OF THEIR USE
|
|
BR112014018481A2
(pt)
|
2012-02-01 |
2017-07-04 |
Compugen Ltd |
anticorpo monoclonal ou policlonal ou um fragmento de ligação a antígeno do mesmo, polinucleotídeo, anticorpo monoclonal, vetor, hibridoma, anticorpo, hibridoma 5166-2 e/ou 5166-9, anticorpo ou fragmento de ligação a antígeno, composição farmacêutica, uso do anticorpo ou fragmento de ligação a anticorpo, método para tratar câncer, método para diagnosticar câncer em um indivíduo, anticorpo, método, composição ou uso
|
|
JP6187256B2
(ja)
|
2012-02-21 |
2017-08-30 |
東レ株式会社 |
癌の治療及び/又は予防用医薬組成物
|
|
PT2824114T
(pt)
|
2012-02-21 |
2019-08-05 |
Toray Industries |
Composição farmacêutica para o tratamento do cancro
|
|
PL2818481T3
(pl)
|
2012-02-21 |
2020-02-28 |
Toray Industries, Inc. |
Kompozycja farmaceutyczna do leczenia i/lub zapobiegania nowotworowi złośliwemu
|
|
JP6187255B2
(ja)
|
2012-02-21 |
2017-08-30 |
東レ株式会社 |
癌の治療及び/又は予防用医薬組成物
|
|
CN107496932A
(zh)
|
2012-02-27 |
2017-12-22 |
阿穆尼克斯运营公司 |
Xten缀合组合物和制造其的方法
|
|
PL2832366T3
(pl)
|
2012-03-30 |
2018-04-30 |
Toray Industries, Inc. |
Kompozycja farmaceutyczna do leczenia i/lub zapobiegania rakowi pęcherzyka żółciowego
|
|
WO2013147169A1
(ja)
|
2012-03-30 |
2013-10-03 |
東レ株式会社 |
肝臓癌の治療及び/又は予防用医薬組成物
|
|
EP2836507A4
(en)
|
2012-04-13 |
2016-08-24 |
Whitehead Biomedical Inst |
SORTAS-MODIFIED VHH DOMAINS AND USES THEREOF
|
|
WO2013166110A1
(en)
|
2012-05-02 |
2013-11-07 |
Yale University |
Tlr-agonist-conjugated antibody recruiting molecules (tlr_arms)
|
|
CN104470991A
(zh)
|
2012-05-30 |
2015-03-25 |
生命科技公司 |
荧光pH敏感性染料和其使用方法
|
|
EP2674170B1
(en)
|
2012-06-15 |
2014-11-19 |
Invivogen |
Novel compositions of TLR7 and/or TLR8 agonists conjugated to lipids
|
|
UA114108C2
(uk)
|
2012-07-10 |
2017-04-25 |
Борд Оф Ріджентс, Дзе Юніверсіті Оф Техас Сістем |
Моноклональне антитіло для застосування в діагностиці і терапії злоякісних пухлин і аутоімунного захворювання
|
|
CN103566377A
(zh)
|
2012-07-18 |
2014-02-12 |
上海博笛生物科技有限公司 |
癌症的靶向免疫治疗
|
|
US9382329B2
(en)
|
2012-08-14 |
2016-07-05 |
Ibc Pharmaceuticals, Inc. |
Disease therapy by inducing immune response to Trop-2 expressing cells
|
|
US20140065096A1
(en)
|
2012-09-05 |
2014-03-06 |
Regen BioPharma, Inc. |
Cancer therapy by ex vivo activated autologous immune cells
|
|
MX2015010146A
(es)
|
2013-02-08 |
2016-05-31 |
Novartis Ag |
Sitios especificos para modificar anticuerpos para hacer inmunoconjugados.
|
|
EP2787005A1
(en)
|
2013-04-02 |
2014-10-08 |
Activartis Biotech GmbH |
Targeted cancer immune therapy
|
|
AR095882A1
(es)
|
2013-04-22 |
2015-11-18 |
Hoffmann La Roche |
Terapia de combinación de anticuerpos contra csf-1r humano con un agonista de tlr9
|
|
GB2529356B
(en)
|
2013-04-28 |
2020-12-23 |
Genequantum Healthcare Co Ltd |
Novel linkers, coupling intermediates, conjugates, preparation method and application thereof
|
|
WO2015014376A1
(en)
|
2013-07-31 |
2015-02-05 |
Biontech Ag |
Diagnosis and therapy of cancer involving cancer stem cells
|
|
DK3031826T3
(en)
|
2013-08-09 |
2018-12-17 |
Toray Industries |
Pharmaceutical composition for the treatment and / or prevention of cancer
|
|
US10836821B2
(en)
|
2013-10-15 |
2020-11-17 |
Sorrento Therapeutics, Inc. |
Drug-conjugates with a targeting molecule and two different drugs
|
|
GB201321242D0
(en)
|
2013-12-02 |
2014-01-15 |
Immune Targeting Systems Its Ltd |
Immunogenic compound
|
|
BR112016013963A2
(pt)
|
2013-12-17 |
2017-10-10 |
Genentech Inc |
terapia de combinação compreendendo agonistas de ligação de ox40 e antagonistas de ligação do eixo de pd-1
|
|
KR20240017102A
(ko)
|
2013-12-17 |
2024-02-06 |
제넨테크, 인크. |
Pd-1 축 결합 길항제 및 탁산을 이용한 암 치료 방법
|
|
KR102444529B1
(ko)
|
2013-12-25 |
2022-09-19 |
다이이찌 산쿄 가부시키가이샤 |
항 trop2 항체-약물 컨쥬게이트
|
|
CA2936376A1
(en)
|
2014-01-10 |
2015-07-16 |
Shanghai Birdie Biotech, Inc. |
Conjugated compounds and compositions for targeted immunotherapy
|
|
CN104861063A
(zh)
*
|
2014-01-10 |
2015-08-26 |
博笛生物科技有限公司 |
靶向her2阳性肿瘤的化合物和组合物
|
|
CN104861067A
(zh)
*
|
2014-01-10 |
2015-08-26 |
博笛生物科技有限公司 |
用于免疫疗法的化合物和组合物
|
|
US20160340439A1
(en)
|
2014-01-22 |
2016-11-24 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and Compositions for Antibody and Antibody-loaded Dendritic Cell Mediated Therapy
|
|
EP3107563B1
(en)
|
2014-02-21 |
2021-04-07 |
Ecole Polytechnique Fédérale de Lausanne (EPFL) EPFL-TTO |
Glycotargeting therapeutics
|
|
JP6357327B2
(ja)
|
2014-03-11 |
2018-07-11 |
株式会社クレハ |
フッ化ビニリデン系共重合体、その製造方法、ゲル電解質および非水系電池
|
|
AU2015229463A1
(en)
|
2014-03-12 |
2016-09-15 |
Novartis Ag |
Specific sites for modifying antibodies to make immunoconjugates
|
|
CN106471010A
(zh)
|
2014-03-19 |
2017-03-01 |
建新公司 |
靶向模块的位点特异性糖工程化
|
|
ES2719584T3
(es)
|
2014-04-11 |
2019-07-11 |
Medimmune Llc |
Compuestos conjugados que comprenden anticuerpos modificados por ingeniería genética con cisteína
|
|
AR100137A1
(es)
|
2014-04-22 |
2016-09-14 |
Hoffmann La Roche |
Compuestos 4-amino-imidazoquinolina
|
|
JP6666264B2
(ja)
|
2014-04-29 |
2020-03-13 |
ジーンクアンタム ヘルスケア (スーチョウ) シーオー., エルティーディー.Genequantum Healthcare (Suzhou)Co., Ltd. |
新規安定型抗体薬物複合体の作製およびその応用
|
|
EP3143045A1
(en)
|
2014-05-12 |
2017-03-22 |
Numab AG |
Novel multispecific molecules and novel treatment methods based on such multispecific molecules
|
|
US10406198B2
(en)
|
2014-05-23 |
2019-09-10 |
Novartis Ag |
Methods for making conjugates from disulfide-containing proteins
|
|
WO2015187637A1
(en)
|
2014-06-02 |
2015-12-10 |
Baylor Research Institute |
Methods and compositions for treating allergy and inflammatory diseases
|
|
PT3151921T
(pt)
|
2014-06-06 |
2019-11-21 |
Bristol Myers Squibb Co |
Anticorpos contra recetor do fator de necrose tumoral induzido por glicocorticoide e utilizações dos mesmos
|
|
JP6760919B2
(ja)
|
2014-07-09 |
2020-09-23 |
バーディー バイオファーマシューティカルズ インコーポレイテッド |
腫瘍を治療するための抗pd−l1組み合わせ
|
|
CN105233291A
(zh)
|
2014-07-09 |
2016-01-13 |
博笛生物科技有限公司 |
用于治疗癌症的联合治疗组合物和联合治疗方法
|
|
CN105440135A
(zh)
|
2014-09-01 |
2016-03-30 |
博笛生物科技有限公司 |
用于治疗肿瘤的抗-pd-l1结合物
|
|
US20160015803A1
(en)
|
2014-07-18 |
2016-01-21 |
Ross Kedl |
Immunostimulatory combinations and use thereof
|
|
US10669337B2
(en)
|
2014-07-25 |
2020-06-02 |
Cytomx Therapeutics, Inc. |
Bispecific anti-CD3 antibodies, bispecific activatable anti-CD3 antibodies, and methods of using the same
|
|
US20170233745A1
(en)
|
2014-08-20 |
2017-08-17 |
Tu Eindhoven |
Ureidopyrimidone supramolecular complexes for compound delivery into cells
|
|
JP2017526673A
(ja)
*
|
2014-08-27 |
2017-09-14 |
国立大学法人九州大学 |
アジュバント
|
|
US9884866B2
(en)
|
2014-09-08 |
2018-02-06 |
Regents Of The University Of Minnesota |
Immunomodulators and immunomodulator conjugates
|
|
ES2774448T3
(es)
|
2014-10-03 |
2020-07-21 |
Novartis Ag |
Terapias de combinación
|
|
MA41044A
(fr)
|
2014-10-08 |
2017-08-15 |
Novartis Ag |
Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
|
|
WO2016057618A1
(en)
|
2014-10-09 |
2016-04-14 |
Wake Forest University Health Sciences |
Vaccine compositions and methods of use to treat neonatal subjects
|
|
GB201418004D0
(en)
|
2014-10-10 |
2014-11-26 |
Isis Innovation |
Polymer adjuvant
|
|
JP6877339B2
(ja)
|
2014-10-14 |
2021-05-26 |
ノバルティス アーゲー |
Pd−l1に対する抗体分子およびその使用
|
|
EP3209334A2
(en)
|
2014-10-20 |
2017-08-30 |
Igenica Biotherapeutics, Inc. |
Novel antibody-drug conjugates and related compounds, compositions, and methods of use
|
|
WO2016064899A1
(en)
|
2014-10-21 |
2016-04-28 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and compositions for antibody and antibody-loaded dendritic cell mediated therapy
|
|
DK3221363T3
(da)
|
2014-11-21 |
2020-08-10 |
Bristol Myers Squibb Co |
Antistoffer mod cd73 og anvendelser deraf
|
|
WO2016085967A1
(en)
|
2014-11-25 |
2016-06-02 |
Endocyte, Inc. |
Methods of treating cancer by targeting tumor-associated macrophages
|
|
WO2016100882A1
(en)
|
2014-12-19 |
2016-06-23 |
Novartis Ag |
Combination therapies
|
|
EP3240801B1
(en)
|
2014-12-31 |
2021-01-20 |
Checkmate Pharmaceuticals, Inc. |
Combination tumor immunotherapy
|
|
JP6676058B2
(ja)
|
2015-01-14 |
2020-04-08 |
ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company |
ヘテロアリーレン架橋したベンゾジアゼピン二量体、そのコンジュゲート、ならびに製造および使用方法
|
|
CA2968141C
(en)
|
2015-01-16 |
2020-08-04 |
Hsing-Mao CHU |
Molecular constructs with targeting and effector elements
|
|
ES2901501T3
(es)
|
2015-01-21 |
2022-03-22 |
Univ Leland Stanford Junior |
Uso de agonistas de TLR y agente anti-CD47 para mejorar la fagocitosis de las células cancerosas
|
|
WO2016145085A2
(en)
|
2015-03-09 |
2016-09-15 |
Celldex Therapeutics, Inc. |
Cd27 agonists
|
|
WO2016141890A1
(en)
|
2015-03-12 |
2016-09-15 |
Sunshine Lake Pharma Co., Ltd. |
Compounds as hepatitis c virus inhibitors and pharmaceutical uses thereof
|
|
SG11201707383PA
(en)
|
2015-03-13 |
2017-10-30 |
Cytomx Therapeutics Inc |
Anti-pdl1 antibodies, activatable anti-pdl1 antibodies, and methods of use thereof
|
|
PE20171790A1
(es)
|
2015-03-23 |
2017-12-28 |
Bayer Pharma AG |
Anticuerpos anti-ceacam6 y sus usos
|
|
WO2016161372A1
(en)
|
2015-04-01 |
2016-10-06 |
President And Fellows Of Harvard College |
Immunoconjugates for programming or reprogramming of cells
|
|
CA2981543A1
(en)
|
2015-04-22 |
2016-10-27 |
Immunomedics, Inc. |
Isolation, detection, diagnosis and/or characterization of circulating trop-2-positive cancer cells
|
|
HRP20200721T1
(hr)
|
2015-05-04 |
2020-10-02 |
Cytomx Therapeutics Inc. |
Aktivirajuća anti-cd166 antitijela i postupci njihove uporabe
|
|
WO2016179335A1
(en)
|
2015-05-04 |
2016-11-10 |
Cytomx Therapeutics, Inc. |
Anti-itga3 antibodies, activatable anti-itga3 antibodies, and methods of use thereof
|
|
US10179817B2
(en)
|
2015-05-04 |
2019-01-15 |
Cytomx Therapeutics, Inc. |
Anti-CD71 antibodies, activatable anti-CD71 antibodies, and methods of use thereof
|
|
US20160324981A1
(en)
|
2015-05-08 |
2016-11-10 |
The California Institute For Biomedical Research |
Liver x receptor agonists and uses thereof
|
|
US10314854B2
(en)
|
2015-05-15 |
2019-06-11 |
University Of Iowa Foundation |
Methods for treating tumors in situ including intratumor injection of cytotoxic particles and immune checkpoint blockade therapy
|
|
TWI614264B
(zh)
|
2015-05-20 |
2018-02-11 |
免疫功坊股份有限公司 |
含胜肽核的多臂接合物及其應用
|
|
CA2986114A1
(en)
|
2015-05-22 |
2016-12-01 |
La Trobe University |
Method of diagnosis of breast cancer
|
|
DK3303396T5
(da)
|
2015-05-29 |
2024-10-07 |
Bristol Myers Squibb Co |
Antistoffer mod ox40 og anvendelser deraf
|
|
IL294138A
(en)
|
2015-05-29 |
2022-08-01 |
Genentech Inc |
Therapeutic and diagnostic methods for cancer
|
|
WO2016198470A2
(en)
|
2015-06-08 |
2016-12-15 |
Lophius Biosciences Gmbh |
Composition for determination of cell-mediated immune responsiveness
|
|
CA2989269C
(en)
|
2015-06-15 |
2020-09-22 |
Robert Yongxin Zhao |
Hydrophilic linkers for conjugation of a cytotoxic agent or chromophore molecule to a cell-binding molecule
|
|
US10975112B2
(en)
|
2015-06-16 |
2021-04-13 |
Hangzhou Dac Biotech Co., Ltd. |
Linkers for conjugation of cell-binding molecules
|
|
WO2016205566A1
(en)
|
2015-06-16 |
2016-12-22 |
The Regents Of The University Of California |
Fzd7 specific antibodies and vaccines to treat cancer and control stem cell function
|
|
US10766962B2
(en)
|
2015-06-16 |
2020-09-08 |
The Regents Of The University Of California |
FZD7 specific antibodies and vaccines to treat cancer and control stem cell function
|
|
US20180296663A1
(en)
|
2015-06-17 |
2018-10-18 |
Curevac Ag |
Vaccine composition
|
|
GB201511546D0
(en)
|
2015-07-01 |
2015-08-12 |
Immatics Biotechnologies Gmbh |
Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers
|
|
WO2015151080A2
(en)
|
2015-07-04 |
2015-10-08 |
Suzhou M-Conj Biotech Co., Ltd |
Specific conjugation of a cell-binding molecule
|
|
EP3319936B1
(en)
|
2015-07-12 |
2025-12-17 |
Hangzhou Dac Biotech Co., Ltd. |
Bridge linkers for conjugation of cell-binding molecules
|
|
MA42447A
(fr)
|
2015-07-13 |
2018-05-23 |
Cytomx Therapeutics Inc |
Anticorps anti-pd-1, anticorps anti-pd-1 activables, et leurs procédés d'utilisation
|
|
US9839687B2
(en)
|
2015-07-15 |
2017-12-12 |
Suzhou M-Conj Biotech Co., Ltd. |
Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
|
|
EP3878465A1
(en)
|
2015-07-29 |
2021-09-15 |
Novartis AG |
Combination therapies comprising antibody molecules to tim-3
|
|
EP3964528A1
(en)
|
2015-07-29 |
2022-03-09 |
Novartis AG |
Combination therapies comprising antibody molecules to lag-3
|
|
WO2017019896A1
(en)
|
2015-07-29 |
2017-02-02 |
Novartis Ag |
Combination therapies comprising antibody molecules to pd-1
|
|
CA2993429A1
(en)
|
2015-07-31 |
2017-02-09 |
Tarveda Therapeutics, Inc. |
Compositions and methods for immuno-oncology therapies
|
|
TW201716084A
(zh)
|
2015-08-06 |
2017-05-16 |
葛蘭素史克智慧財產發展有限公司 |
組合物及其用途與治療
|
|
AU2016304597B2
(en)
|
2015-08-06 |
2022-10-06 |
Memorial Sloan Kettering Cancer Center |
Methods and compositions for tumor therapy
|
|
JP6817288B2
(ja)
|
2015-08-10 |
2021-01-20 |
ハンジョウ ディーエーシー バイオテック シーオー.,エルティディ.Hangzhou Dac Biotech Co.,Ltd. |
新規な連結体及び生体分子と薬物との特異的共役におけるその使用
|
|
CN113402518B
(zh)
|
2015-08-31 |
2023-08-22 |
3M创新有限公司 |
含有取代的胍基团的咪唑并[4,5-c]环化合物
|
|
CA2996213C
(en)
|
2015-08-31 |
2023-10-03 |
3M Innovative Properties Company |
Guanidine substituted imidazo[4,5-c] ring compounds
|
|
AU2016316202B2
(en)
|
2015-09-01 |
2018-11-15 |
Immunwork Inc. |
Molecular constructs for preventing the formation of blood clot and/or treating thrombosis
|
|
EP3347047A1
(en)
|
2015-09-09 |
2018-07-18 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Expression vector delivery system and use thereof for inducing an immune response
|
|
KR102161364B1
(ko)
|
2015-09-14 |
2020-09-29 |
화이자 인코포레이티드 |
LRRK2 억제제로서 이미다조[4,5-c]퀴놀린 및 이미다조[4,5-c][1,5]나프티리딘 유도체
|
|
US20180273948A1
(en)
|
2015-09-25 |
2018-09-27 |
Tarveda Therapeutics, Inc. |
RNAi CONJUGATES, PARTICLES AND FORMULATIONS THEREOF
|
|
JP2018531318A
(ja)
|
2015-09-29 |
2018-10-25 |
ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago |
ポリマーコンジュゲートワクチン
|
|
MA44334A
(fr)
|
2015-10-29 |
2018-09-05 |
Novartis Ag |
Conjugués d'anticorps comprenant un agoniste du récepteur de type toll
|
|
US20180303845A1
(en)
|
2015-11-02 |
2018-10-25 |
Ventirx Pharmaceuticals, Inc. |
Use of tlr8 agonists to treat cancer
|
|
WO2017083525A1
(en)
|
2015-11-11 |
2017-05-18 |
Opi Vi- Ip Holdco Llc |
Composition and methods for anti-tnfr2 antibodies
|
|
WO2017087280A1
(en)
|
2015-11-16 |
2017-05-26 |
Genentech, Inc. |
Methods of treating her2-positive cancer
|
|
TWI637966B
(zh)
|
2015-11-30 |
2018-10-11 |
輝瑞股份有限公司 |
用於部位專一性接合之抗體和抗體片段
|
|
KR101795388B1
(ko)
|
2015-12-02 |
2017-11-09 |
현대자동차 주식회사 |
차량용 자동변속기의 유성기어트레인
|
|
US20170158772A1
(en)
|
2015-12-07 |
2017-06-08 |
Opi Vi - Ip Holdco Llc |
Compositions of antibody construct - agonist conjugates and methods of use thereof
|
|
WO2017100305A2
(en)
|
2015-12-07 |
2017-06-15 |
Opi Vi - Ip Holdco Llc |
Composition of antibody construct-agonist conjugates and methods of use thereof
|
|
EP4424322A3
(en)
|
2015-12-17 |
2025-04-16 |
Novartis AG |
Antibody molecules to pd-1 and uses thereof
|
|
US20190010236A1
(en)
|
2015-12-29 |
2019-01-10 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and compositions for dectin-2 stimulation and cancer immunotherapy
|
|
CN106943596A
(zh)
|
2016-01-07 |
2017-07-14 |
博笛生物科技(北京)有限公司 |
用于治疗肿瘤的抗-cd20组合
|
|
CN106943597A
(zh)
|
2016-01-07 |
2017-07-14 |
博笛生物科技(北京)有限公司 |
用于治疗肿瘤的抗-egfr组合
|
|
CN106943598A
(zh)
|
2016-01-07 |
2017-07-14 |
博笛生物科技(北京)有限公司 |
用于治疗肿瘤的抗-her2组合
|
|
PH12018501638B1
(en)
|
2016-02-04 |
2022-11-04 |
Hangzhou Dac Biotech Co Ltd |
Specific conjugation linkers, specific immunoconjugates thereof, methods of making and uses such conjugates thereof
|
|
WO2017165464A1
(en)
|
2016-03-21 |
2017-09-28 |
Elstar Therapeutics, Inc. |
Multispecific and multifunctional molecules and uses thereof
|
|
EP3442592A4
(en)
|
2016-04-13 |
2019-11-27 |
Tarveda Therapeutics, Inc. |
NEUROTENSIN RECEPTOR BINDING CONJUGATES AND FORMULATIONS THEREOF
|
|
SG11201808821WA
(en)
|
2016-04-18 |
2018-11-29 |
Celldex Therapeutics Inc |
Agonistic antibodies that bind human cd40 and uses thereof
|
|
MX2018012249A
(es)
|
2016-04-19 |
2019-02-07 |
Innate Tumor Immunity Inc |
Moduladores de nlpr3.
|
|
US10533007B2
(en)
|
2016-04-19 |
2020-01-14 |
Innate Tumor Immunity, Inc. |
NLRP3 modulators
|
|
CA3021669A1
(en)
|
2016-05-09 |
2017-11-16 |
Igm Biosciences, Inc. |
Anti-pd-l1 antibodies
|
|
WO2017197241A1
(en)
|
2016-05-13 |
2017-11-16 |
Tarveda Therapeutics, Inc. |
Targeted constructs and formulations thereof
|
|
WO2017210246A2
(en)
|
2016-05-31 |
2017-12-07 |
Tarveda Therapeutics, Inc. |
Penicillamine conjugates and particles and formulations thereof
|
|
US12257352B2
(en)
|
2016-06-20 |
2025-03-25 |
The Regents Of The University Of Michigan |
Compositions and methods for delivery of biomacromolecule agents
|
|
US10858483B2
(en)
|
2016-07-06 |
2020-12-08 |
University Of Maryland, College Park |
Polyphosphazene polyelectrolytes and uses thereof
|
|
AU2017292934B9
(en)
|
2016-07-07 |
2024-08-29 |
Bolt Biotherapeutics, Inc. |
Antibody adjuvant conjugates
|
|
BR112019004042A2
(pt)
|
2016-08-30 |
2019-05-28 |
Dana-Farber Cancer Institute, Inc. |
composições de liberação de fármaco e usos das mesmas
|
|
EP3507288B1
(en)
|
2016-09-02 |
2020-08-26 |
Gilead Sciences, Inc. |
4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators
|
|
BE1024865B1
(fr)
|
2016-09-07 |
2018-07-31 |
Glaxosmithkline Biologicals Sa |
Derives d'imidazoquinoleine
|
|
DK3510033T3
(da)
|
2016-09-09 |
2022-02-28 |
Novartis Ag |
Forbindelser og sammensætninger som inhibitorer af endosomale toll-lignende receptorer
|
|
JP7265989B2
(ja)
|
2016-10-25 |
2023-04-27 |
ウロゲン ファーマ リミテッド |
体腔の免疫調節治療
|
|
WO2018079740A1
(ja)
|
2016-10-28 |
2018-05-03 |
東レ株式会社 |
癌の治療及び/又は予防用医薬組成物
|
|
KR20220147721A
(ko)
|
2016-11-14 |
2022-11-03 |
항저우 디에이씨 바이오테크 씨오, 엘티디 |
결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
|
|
WO2018112108A1
(en)
|
2016-12-13 |
2018-06-21 |
Bolt Biotherapeutics, Inc. |
Antibody adjuvant conjugates
|
|
JP2020500264A
(ja)
|
2016-12-15 |
2020-01-09 |
アーコニック インコーポレイテッドArconic Inc. |
耐食性アルミニウム合金
|
|
JP7128529B2
(ja)
|
2016-12-23 |
2022-08-31 |
アールイーエムディー バイオセラピューティクス,インコーポレイテッド |
プログラム死リガンド-1(pd-l1)に結合する抗体を使用する免疫
|
|
JP7122758B2
(ja)
|
2016-12-23 |
2022-08-22 |
アールイーエムディー バイオセラピューティクス,インコーポレイテッド |
プログラム死-1(pd-1)に結合する抗体を使用する免疫療法
|
|
WO2018132496A1
(en)
|
2017-01-10 |
2018-07-19 |
Nektar Therapeutics |
Multi-arm polymer conjugates of tlr agonist compounds and related immunotherapeutic treatment methods
|
|
US20190336615A1
(en)
|
2017-01-27 |
2019-11-07 |
Silverback Therapeutics, Inc. |
Tumor targeting conjugates and methods of use thereof
|
|
EP3576782A4
(en)
|
2017-02-02 |
2020-12-30 |
Silverback Therapeutics, Inc. |
COMPOSITIONS OF RECOMBINATION PRODUCT-PEPTIDE AND THEIR METHODS OF USE
|
|
TWI674261B
(zh)
|
2017-02-17 |
2019-10-11 |
美商英能腫瘤免疫股份有限公司 |
Nlrp3 調節劑
|
|
US20190374650A1
(en)
|
2017-02-22 |
2019-12-12 |
The Regents Of The University Of Michigan |
Compositions and methods for delivery of polymer/biomacromolecule conjugates
|
|
EA201992027A1
(ru)
|
2017-03-06 |
2020-02-25 |
Мерк Патент Гмбх |
Водный состав антитела против pd-l1
|
|
HUE056427T2
(hu)
|
2017-03-15 |
2022-02-28 |
Silverback Therapeutics Inc |
Benzazepin vegyületek, konjugátumok és alkalmazásaik
|
|
AU2018233403B2
(en)
|
2017-03-16 |
2021-02-25 |
Immunwork Inc. |
Linker units and molecular constructs comprising same
|
|
WO2018175854A1
(en)
|
2017-03-23 |
2018-09-27 |
The Children's Medical Center Corporation |
Methods and compositions relating to adjuvants
|
|
RU2019134273A
(ru)
|
2017-03-31 |
2021-04-30 |
Займворкс Инк. |
Конструкты индуктора презентации антигена опухоли и их использование
|
|
WO2018187515A1
(en)
|
2017-04-04 |
2018-10-11 |
Avidea Technologies, Inc. |
Peptide-based vaccines, methods of manufacturing, and uses thereof for inducing an immune response
|
|
SG11201908721TA
(en)
|
2017-04-06 |
2019-10-30 |
Hangzhou Dac Biotech Co Ltd |
Conjugation of a cytotoxic drug with bis-linkage
|
|
US20180296685A1
(en)
|
2017-04-13 |
2018-10-18 |
Tarveda Therapeutics, Inc. |
Targeted constructs and formulations thereof
|
|
US20210284750A1
(en)
|
2017-04-14 |
2021-09-16 |
Bolt Biotherapeutics, Inc. |
Immunoconjugate Synthesis Method
|
|
CA3058944A1
(en)
|
2017-04-19 |
2018-10-25 |
Elstar Therapeutics, Inc. |
Multispecific molecules and uses thereof
|
|
CN118515666A
(zh)
|
2017-04-27 |
2024-08-20 |
博笛生物科技有限公司 |
2-氨基-喹啉衍生物
|
|
AR111651A1
(es)
|
2017-04-28 |
2019-08-07 |
Novartis Ag |
Conjugados de anticuerpos que comprenden agonistas del receptor de tipo toll y terapias de combinación
|
|
AR111760A1
(es)
|
2017-05-19 |
2019-08-14 |
Novartis Ag |
Compuestos y composiciones para el tratamiento de tumores sólidos mediante administración intratumoral
|
|
JP2020521759A
(ja)
|
2017-05-26 |
2020-07-27 |
ザ・ジョンズ・ホプキンス・ユニバーシティ |
免疫トレランスを調節するための多機能性の抗体−リガンド・トラップ
|
|
CA3065919A1
(en)
|
2017-06-07 |
2018-12-13 |
Silverback Therapeutics, Inc. |
Antibody construct conjugates
|
|
WO2018227018A1
(en)
|
2017-06-07 |
2018-12-13 |
Silverback Therapeutics, Inc. |
Antibody conjugates of immune-modulatory compounds and uses thereof
|
|
KR20200019226A
(ko)
|
2017-06-23 |
2020-02-21 |
버디 바이오파마슈티칼즈, 인크. |
약학 조성물
|
|
AU2018290880A1
(en)
|
2017-06-28 |
2020-01-16 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and compositions for Dectin-2 stimulation and cancer immunotherapy
|
|
US11925693B2
(en)
|
2017-07-27 |
2024-03-12 |
The Board Of Trustees Of The Leland Stanford Junior University |
Polymeric nanoparticles for enhanced cancer immunotherapy
|
|
US10494370B2
(en)
|
2017-08-16 |
2019-12-03 |
Bristol-Myers Squibb Company |
Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor
|
|
US10508115B2
(en)
|
2017-08-16 |
2019-12-17 |
Bristol-Myers Squibb Company |
Toll-like receptor 7 (TLR7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor
|
|
US10457681B2
(en)
|
2017-08-16 |
2019-10-29 |
Bristol_Myers Squibb Company |
Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor
|
|
US10487084B2
(en)
|
2017-08-16 |
2019-11-26 |
Bristol-Myers Squibb Company |
Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor
|
|
US10472361B2
(en)
|
2017-08-16 |
2019-11-12 |
Bristol-Myers Squibb Company |
Toll-like receptor 7 (TLR7) agonists having a benzotriazole moiety, conjugates thereof, and methods and uses therefor
|
|
WO2019036031A2
(en)
|
2017-08-17 |
2019-02-21 |
Nektar Therapeutics |
IMMUNOTHERAPEUTIC METHOD FOR TUMOR TREATMENT
|
|
EP3694881A1
(en)
|
2017-10-13 |
2020-08-19 |
OSE Immunotherapeutics |
Modified anti-sirpa antibodies and uses thereof
|
|
WO2019084060A1
(en)
|
2017-10-24 |
2019-05-02 |
Silverback Therapeutics, Inc. |
CONJUGATES AND METHODS OF USE FOR THE SELECTIVE DELIVERY OF IMMUNOMODULATORY AGENTS
|
|
US10722591B2
(en)
|
2017-11-14 |
2020-07-28 |
Dynavax Technologies Corporation |
Cleavable conjugates of TLR7/8 agonist compounds, methods for preparation, and uses thereof
|
|
JP2021506827A
(ja)
|
2017-12-15 |
2021-02-22 |
シルバーバック セラピューティックス インコーポレイテッド |
肝炎の治療用の抗体コンストラクト−薬物コンジュゲート
|
|
EP3727146A4
(en)
|
2017-12-19 |
2021-10-06 |
Blaze Bioscience, Inc. |
CELL PENETRATION PEPTIDE TUMOR AND IMMUNO-ONCOLOGY ADDRESSING AGENT COMPLEXES AND METHODS OF USE
|
|
KR20210006338A
(ko)
|
2018-03-13 |
2021-01-18 |
오제 이뮈노테라프틱스 |
항-인간 SIRPa v1 항체의 이용 및 항-SIRPa v1 항체를 생산하는 방법
|
|
WO2019178364A2
(en)
|
2018-03-14 |
2019-09-19 |
Elstar Therapeutics, Inc. |
Multifunctional molecules and uses thereof
|
|
WO2019195278A1
(en)
|
2018-04-02 |
2019-10-10 |
Silverback Therapeutics, Inc. |
Alk5 inhibitors, conjugates, and uses thereof
|
|
CN108379591B
(zh)
|
2018-04-03 |
2022-03-29 |
深圳大学 |
免疫激动剂靶向化合物的合成及其应用
|
|
WO2019209811A1
(en)
|
2018-04-24 |
2019-10-31 |
Bristol-Myers Squibb Company |
Macrocyclic toll-like receptor 7 (tlr7) agonists
|
|
CN112153988A
(zh)
|
2018-05-17 |
2020-12-29 |
博尔特生物治疗药物有限公司 |
免疫缀合物
|
|
US20210353652A1
(en)
|
2018-06-04 |
2021-11-18 |
Trustees Of Tufts College |
Tumor microenvironment-activated drug-binder conjugates, and uses related thereto
|
|
CN112771161A
(zh)
|
2018-07-09 |
2021-05-07 |
启德医药科技(苏州)有限公司 |
滋养层细胞表面抗原2(trop2)特异性抗体
|
|
AU2019311102A1
(en)
|
2018-07-24 |
2021-02-25 |
Torque Therapeutics, Inc |
TLR7/8 agonists and liposome compositions
|
|
US11554120B2
(en)
|
2018-08-03 |
2023-01-17 |
Bristol-Myers Squibb Company |
1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor
|
|
CN112739385A
(zh)
|
2018-08-29 |
2021-04-30 |
博尔特生物治疗药物有限公司 |
靶向egfr的免疫缀合物
|
|
US20210214354A1
(en)
|
2018-09-07 |
2021-07-15 |
Birdie Biopharmaceuticals, Inc. |
Imidazoquinoline compounds and uses thereof
|
|
EP3849665A1
(en)
|
2018-09-12 |
2021-07-21 |
Silverback Therapeutics, Inc. |
Antibody conjugates of toll-like receptor agonists
|
|
KR20210081339A
(ko)
|
2018-09-12 |
2021-07-01 |
실버백 테라퓨틱스, 인크. |
치환된 벤즈아제핀 화합물, 접합체, 및 이의 용도
|
|
WO2020056194A1
(en)
|
2018-09-12 |
2020-03-19 |
Silverback Therapeutics, Inc. |
Benzazepine compounds, conjugates, and uses thereof
|
|
SG11202101980VA
(en)
|
2018-09-12 |
2021-03-30 |
Silverback Therapeutics Inc |
Methods and composition for the treatment of disease with immune stimulatory conjugates
|
|
EP3873532A1
(en)
|
2018-10-31 |
2021-09-08 |
Novartis AG |
Dc-sign antibody drug conjugates
|
|
CN113348181A
(zh)
|
2018-10-31 |
2021-09-03 |
诺华股份有限公司 |
包含sting激动剂的dc-sign抗体缀合物
|
|
ES2943474T3
(es)
|
2018-11-30 |
2023-06-13 |
Bristol Myers Squibb Co |
Anticuerpo que comprende una extensión carboxiterminal de una cadena ligera que contiene glutamina, conjugados del mismo, y métodos y usos
|
|
CN113544155A
(zh)
|
2018-12-12 |
2021-10-22 |
百时美施贵宝公司 |
经修饰用于转谷氨酰胺酶缀合的抗体、其缀合物以及方法和用途
|
|
CN113613641A
(zh)
|
2018-12-26 |
2021-11-05 |
博笛生物科技有限公司 |
用于治疗癌症的免疫调节组合和方法
|
|
CN113543808A
(zh)
|
2019-01-04 |
2021-10-22 |
特瑞奥制药公司 |
多特异性蛋白质分子及其用途
|
|
JP2022516308A
(ja)
|
2019-01-04 |
2022-02-25 |
アセンディス ファーマ オンコロジー ディヴィジョン エー/エス |
パターン認識受容体アゴニストのコンジュゲート
|
|
CN119455004A
(zh)
|
2019-02-12 |
2025-02-18 |
Ambrx公司 |
包含抗体-tlr激动剂缀合物的组合物、方法和用途
|
|
WO2020190731A1
(en)
|
2019-03-15 |
2020-09-24 |
Bolt Biotherapeutics, Inc. |
Immunoconjugates targeting her2
|
|
WO2020190734A1
(en)
|
2019-03-15 |
2020-09-24 |
Bolt Biotherapeutics, Inc. |
Immunoconjugates targeting pd-l1
|
|
US20220152215A1
(en)
|
2019-03-15 |
2022-05-19 |
Bolt Biotherapeutics, Inc. |
Immunoconjugates Targeting CEA
|
|
WO2020190762A1
(en)
|
2019-03-15 |
2020-09-24 |
Bolt Biotherapeutics, Inc. |
Macromolecule-supported tlr agonists
|
|
JP2022525216A
(ja)
|
2019-03-15 |
2022-05-11 |
バーディー バイオファーマシューティカルズ インコーポレイテッド |
癌の治療のための免疫調節組成物および方法
|
|
AU2020241686A1
(en)
|
2019-03-15 |
2021-11-04 |
Bolt Biotherapeutics, Inc. |
Immunoconjugates targeting HER2
|
|
CN114502585A
(zh)
|
2019-04-05 |
2022-05-13 |
德伦生物公司 |
通过抗体靶向吞噬作用除尽致病因子的方法
|
|
WO2020252015A1
(en)
|
2019-06-10 |
2020-12-17 |
Sutro Biopharma, Inc. |
Immunomodulator antibody drug conjugates and uses thereof
|
|
US20220315537A1
(en)
|
2019-06-13 |
2022-10-06 |
Bolt Biotherapeutics, Inc. |
Macromolecule-supported aminobenzazepine compounds
|
|
US20200390899A1
(en)
|
2019-06-13 |
2020-12-17 |
Bolt Biotherapeutics, Inc. |
Aminobenzazepine compounds, immunoconjugates, and uses thereof
|
|
CN114746420A
(zh)
|
2019-06-17 |
2022-07-12 |
苏特罗生物制药公司 |
用于癌症治疗和诊断的作为Toll样受体(TLR)7/8激动剂的1-(4-(氨基甲基)苄基)-2-丁基-2H-吡唑并[3,4-c]喹啉-4-胺衍生物及相关化合物以及其抗体药物偶联物
|
|
WO2020257407A1
(en)
|
2019-06-19 |
2020-12-24 |
Silverback Therapeutics, Inc. |
Anti-mesothelin antibodies and immunoconjugates thereof
|
|
CA3146661A1
(en)
|
2019-07-16 |
2021-01-21 |
Silverback Therapeutics, Inc. |
Alk5 inhibitors, conjugates, and uses thereof
|
|
US11339159B2
(en)
|
2019-07-17 |
2022-05-24 |
Pfizer Inc. |
Toll-like receptor agonists
|
|
JP2022543086A
(ja)
|
2019-08-02 |
2022-10-07 |
メルサナ セラピューティクス インコーポレイテッド |
がんの処置用のSTING(インターフェロン遺伝子刺激因子)アゴニストとしてのビス-[N-((5-カルバモイル)-1H-ベンゾ[d]イミダゾール-2-イル)-ピラゾール-5-カルボキサミド]誘導体および関連化合物
|
|
WO2021030665A1
(en)
|
2019-08-15 |
2021-02-18 |
Silverback Therapeutics, Inc. |
Formulations of benzazepine conjugates and uses thereof
|
|
CN114630684A
(zh)
|
2019-09-03 |
2022-06-14 |
博尔特生物治疗药物有限公司 |
氨基喹啉化合物、免疫缀合物及其用途
|
|
US20220347312A1
(en)
|
2019-09-04 |
2022-11-03 |
Bolt Biotherapeutics, Inc. |
Immunoconjugate Synthesis Method
|
|
CN114650844A
(zh)
|
2019-09-23 |
2022-06-21 |
西托姆克斯治疗公司 |
抗cd47抗体、可活化抗cd47抗体及其使用方法
|
|
EP4038053A1
(en)
|
2019-09-30 |
2022-08-10 |
Bolt Biotherapeutics, Inc. |
Amide-linked, aminobenzazepine immunoconjugates, and uses thereof
|
|
CN114585382A
(zh)
|
2019-09-30 |
2022-06-03 |
小利兰·斯坦福大学理事会 |
扭结菌素-免疫刺激缀合物和相关组合物和方法
|
|
CA3151322A1
(en)
|
2019-10-01 |
2021-04-08 |
Silverback Therapeutics, Inc. |
Combination therapy with immune stimulatory conjugates
|
|
WO2021072203A1
(en)
|
2019-10-09 |
2021-04-15 |
Silverback Therapeutics, Inc. |
Tgfbetar1 inhibitor-asgr antibody conjugates and uses thereof
|
|
TWI857167B
(zh)
|
2019-10-25 |
2024-10-01 |
美商博特生物治療公司 |
噻吩并氮呯免疫結合物及其用途
|
|
JP2022554094A
(ja)
|
2019-10-25 |
2022-12-28 |
ボルト バイオセラピューティクス、インコーポレーテッド |
高分子支持チエノアゼピン化合物、及びそれらの使用
|
|
WO2021113679A1
(en)
|
2019-12-06 |
2021-06-10 |
Mersana Therapeutics, Inc. |
Dimeric compounds as sting agonists
|
|
MX2022006578A
(es)
|
2019-12-17 |
2022-07-04 |
Pfizer |
Anticuerpos especificos para cd47, pd-l1 y sus usos.
|
|
US20230101266A1
(en)
|
2019-12-31 |
2023-03-30 |
Genequantum Healthcare (Suzhou) Co., Ltd. |
Anti-trop2 antibodies, antibody-drug conjugates, and application of the same
|
|
US20230256108A1
(en)
|
2019-12-31 |
2023-08-17 |
Genequantum Healthcare (Suzhou) Co., Ltd. |
A drug conjugate and applications thereof
|
|
WO2021150702A1
(en)
|
2020-01-21 |
2021-07-29 |
Bolt Biotherapeutics, Inc. |
Anti-pd-l1 antibodies
|
|
CN115151308A
(zh)
|
2020-01-21 |
2022-10-04 |
博尔特生物治疗药物有限公司 |
抗pd-l1抗体
|
|
WO2021168274A1
(en)
|
2020-02-21 |
2021-08-26 |
Silverback Therapeutics, Inc. |
Nectin-4 antibody conjugates and uses thereof
|
|
WO2021173832A1
(en)
|
2020-02-25 |
2021-09-02 |
Bolt Biotherapeutics, Inc. |
Cancer treatment methods
|
|
WO2021202921A1
(en)
|
2020-04-01 |
2021-10-07 |
Altimmune Uk Limited |
Imidazoquinoline-type compounds and uses thereof
|
|
BR112022020332A2
(pt)
|
2020-04-10 |
2022-12-13 |
Seagen Inc |
Composto conjugado anticorpo-droga, composição, método de tratamento de câncer e de um distúrbio autoimune
|
|
CR20220582A
(es)
|
2020-05-01 |
2023-01-09 |
Bolt Biotherapeutics Inc |
Anticuerpos anti-dectina-2
|
|
CA3176626A1
(en)
|
2020-05-08 |
2021-11-11 |
David Dornan |
Elastase-substrate, peptide linker immunoconjugates, and uses thereof
|