JP2018535067A - デッドスペースを減少させた流体送達用医療機器 - Google Patents
デッドスペースを減少させた流体送達用医療機器 Download PDFInfo
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- JP2018535067A JP2018535067A JP2018538074A JP2018538074A JP2018535067A JP 2018535067 A JP2018535067 A JP 2018535067A JP 2018538074 A JP2018538074 A JP 2018538074A JP 2018538074 A JP2018538074 A JP 2018538074A JP 2018535067 A JP2018535067 A JP 2018535067A
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- plunger
- region
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- syringe
- wall
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Abstract
Description
近位開口部と中心軸とを有する円筒状の穴部を備えた医薬品用シリンジであって、穴部に設けられると共に流出口を画定する遠位壁と、外周部と遠位面とを有するプランジャ封止部とを備え、流出口は遠位壁の第1領域に向かって中心軸から偏倚していると共に第1領域とは異なる第2領域から離れるように中心軸から偏倚しており、外周部はプランジャ封止部が円筒状の穴部に対して同軸となる状態において円筒状の穴部に取り付けられる大きさおよび形状を有し、遠位面が穴部の遠位壁の内面に対向した状態においてプランジャ封止部が穴部の内部に取り付けられた際、内面の第2領域が円筒状の穴部の中心軸に平行な方向において第1領域よりもプランジャ封止部の遠位面に対して軸方向に近接している、医薬品用シリンジ。
内面の平均方位は中心軸に対して傾いている、例1に記載の医薬品用シリンジ。
内面の平均方位は約1度から約5度の範囲の角度となるように中心軸に対して傾いている、例2に記載の医薬品用シリンジ。
内面の第2領域は、プランジャ封止部の遠位面に対して軸方向に近接していることにより、遠位面が第1領域に接触する前にプランジャの遠位面のうちの少なくとも40%に接触可能である、例1から例3のいずれか1つに記載の医薬品用シリンジ。
プランジャ封止部の遠位面は凸形状を有する、例1から例4のいずれか1つに記載の医薬品用シリンジ。
内壁は凹形状を有する、例5に記載の医薬品用シリンジ。
内壁は円錐形状を有し、その内壁の開口角度はプランジャ封止部の遠位面の凸形状の開口角度よりも小さい、例6に記載の医薬品用シリンジ。
内面は放射対称性を有していない、例1から例7のいずれか1つに記載の医薬品用シリンジ。
内面の第1領域の平均方位は、プランジャ封止部が穴部に対して同軸となった際、プランジャ封止部の遠位面の平均方位から離れるように傾斜している、例1から例8のいずれか1つに記載の医薬品用シリンジ。
内壁の第2領域の平均方位は、プランジャ封止部が穴部に対して同軸となった際、プランジャ封止部の遠位面の平均方位に向かうように傾斜している、例1から例8のいずれか1つに記載の医薬品用シリンジ。
軸方向における近接は、プランジャの遠位面の平均外縁と第2領域の平均外縁との間の距離がプランジャの遠位面の平均外縁と第1領域の平均外縁との間の距離よりも小さいことを含む、例1から例10のいずれか1つに記載の医薬品用シリンジ。
内面の第1領域の表面と内面の第2領域の表面との間の推移は連続的である、例1から例11のいずれか1つに記載の医薬品用シリンジ。
偏倚流体流出口を含む内壁の第1領域は穴部の縁部に近接した位置に配置されており、第2領域は穴部の反対側の縁部に近接した位置に配置されている、例1から例12のいずれか1つに記載の医薬品用シリンジ。
さらに、偏倚流体流出口を起点とする屈曲流体路を備えた、例1から例13のいずれか1つに記載の医薬品用シリンジ。
近位開口部と偏倚した位置に配置された遠位流体流出口とを有すると共に、プランジャ封止部を取り付ける円筒状の穴部を備えた医薬品用シリンジにおける流体のデッドスペースを減少させる方法であって、円筒状の穴部の遠位端に向かってプランジャ封止部を駆動させる工程と、偏倚流体流出口を含む領域とは異なる接触領域においてプランジャ封止部の遠位面の一部を穴部の遠位端の壁の内面の一部に接触させる工程と、プランジャの遠位面の平均方位に対して傾いた平均方位に向かって流体を排出させながら接触位置から偏倚流体流出口の位置に向かって接触範囲を拡大させる工程とを含む、医薬品用シリンジにおける流体のデッドスペースを減少させる方法。
接触させる工程は内面の周縁部である接触領域において最初に接触させることを含み、周縁部は偏倚流体流出口を含む領域とは異なっている、例15に記載の方法。
接触領域において接触させる工程は、偏倚流体流出口を含む領域に接触させる前にプランジャの遠位面のうちの少なくとも40%に接触させることを含む、例15に記載の方法。
拡大させる工程は、周縁部から内壁の中心部を経由して偏倚流体流出口を含む領域まで接触範囲を拡大させることを含む、例15から例17のいずれか1つに記載の方法。
プランジャ封止部を弾性変形させることにより、接触範囲を拡大させる工程を行う、例15から例18のいずれか1つに記載の方法。
接触範囲を拡大させる工程は、偏倚流体流出口の位置に向かって接触位置から離れるように流体を流動させる、例15から例19のいずれか1つに記載の方法。
さらに、プランジャ封止部を駆動させる工程を終了させる工程を含み、約5Nと約25Nとの間の範囲の力により、プランジャ封止部を駆動させる工程を行う、例15から例20のいずれか1つに記載の方法。
終了させる工程を経たのち、プランジャ封止部と内壁との間における流体のデッドスペースの体積は約0.01mlと約0.5mlとの間の範囲である、例21に記載の方法。
本発明の一側面は、流体を貯蔵するための容器(reservoir)を有すると共に、流体のデッドスペースが減少した非対称シリンジに関する。いくつかの実施の形態では、シリンジの穴部(bore)の内部にプランジャ封止部(plunger seal)を取り付けることにより、穴部の近位部からその穴部の遠位部に設けられた流体路に向かって流体を駆動させる。流体路は、偏心位置に配置された流出口の流体路である。いくつかの実施の形態では、容器の遠位内壁は、プランジャ封止部に接触した際に、偏心流出口の流体路に向かって流体を流動させる形状を有しており、流体のデッドスペースを減少させ得るようになっている。例えば、プランジャ封止部は、遠位内壁の中心部に接触する前に、容器の遠位内壁の周囲部に接触したのち、その遠位内壁の反対側の周囲部に接触するように構成されていてもよい。遠位内壁の反対側の周囲部は、穴部から退出する流体路を含む部分である。任意に、プランジャと壁との接触部分を拡大させると共に、非接触部分に向かって流体を排出させることにより、偏心流出口の流体路に向かって流体を排除してもよい。
以下、図面を参照する。図1は、本発明のいくつかの実施の形態に係るシリンジにおいて流体のデッドスペースを減少させるための全体的かつ模式的な機構を示すブロック図である。シリンジは、円筒状の穴部101と、開口した近位端107と、遠位端105に位置する流体流出口130とを有している。穴部101は、プランジャ封止部120を取り付けるためのものである。流体流出口130は、偏心した位置に配置されている。
図2は、本発明のいくつかの実施の形態に係る偏心流体流出口を有するシリンジにおいて流体のデッドスペースを減少させる方法を示すフローチャートである。カートリッジから流体流出口を経由して流体を排出させるために、カートリッジの遠位部に向かってプランジャ封止部202を駆動させる工程202を行う。遠位部は、流出口を含んでいる。
図3は、本発明のいくつかの実施の形態に係る、図1に示す構造および/または図2に例示する方法により生じ得る流体力学的経路を例示する図である。
図4は、非対称シリンジの例を模式的に示す図である。この非対称シリンジは、例えば、薬物送達装置に有用であり、本発明のいくつかの実施の形態に用いられるものである。
図5A〜図5Eは、本発明のいくつかの実施の形態に係る遠位内壁の一構成例を示す図である。この遠位内壁の構成によりプランジャと壁との界面が形成されるため、流体のデッドスペースを減少させ得る。
図6は、本発明のいくつかの実施の形態に係る傾斜した遠位内壁678と傾斜したハブ436とを含むシリンジの遠位部609の断面図である。ハブ436は、円筒状の空洞432の中心から偏心した位置に設けられている。例えば、流体路は、偏心流出口456の位置において、穴部442の空洞432に接続されていてもよい。いくつかの実施の形態では、プランジャ封止部670の遠位面は、開口角度668を有するほぼ円錐状の凸部を有していてもよい。いくつかの実施の形態では、円筒状の空洞432の遠位壁の内面678は、開口角度666を有するほぼ凹状の円錐形状を有していてもよい。任意に、プランジャ封止部の遠位面の開口角度668は、円筒状の空洞432の遠位内壁678の開口角度666よりも鋭角であってもよい。任意に、円筒状の空洞432の遠位内壁678は、プランジャ封止部670の遠位面に対して傾斜していてもよい。例えば、遠位内壁678は、プランジャ670面により画定される平均方位に対してオフセットした平均方位を有していてもよい。成形を経た特徴部分をより好ましく示すために、図6では、流体路450の境界を形成する針452の図示を省略している。なお、針452は任意である。
図7は、本発明のいくつかの実施の形態に係るシリンジの穴部の中心長手軸に対して角度が変化する複数の壁を示す図である。
図8は、本発明のいくつかの実施の形態に係る平坦な遠位面875を有するプランジャ封止部870を備えた医薬品シリンジを模式的に示す図である。いくつかの実施の形態では、シリンジ800は、流体を貯蔵するためのカートリッジ842を備えている。カートリッジ842は、遠位内面888において終端する遠位端838を有している。遠位内面888は、背部側882および腹部側884を備えている。いくつかの実施の形態では、背部側882の近位に流体流出口856が配置されている。流体流出口856は、中心軸858に対して偏心した位置に配置されている。任意に、流体は、流出口856を経由して流体路850を介して排出されてもよい。
本出願から満期となるまでの特許の存続期間中、関連する多くのシリンジ装置が開発されることが予想されるが、シリンジおよび/またはカートリッジという用語の範囲は、そのような自明な新技術の全てを含むことを意図している。
Claims (22)
- 近位開口部と中心軸とを有する円筒状の穴部を備えた医薬品用シリンジであって、
前記穴部に設けられると共に、流出口を画定する遠位壁と、
外周部と遠位面とを有するプランジャ封止部と、
を備え、
前記流出口は、前記遠位壁の第1領域に向かって前記中心軸から偏倚していると共に、前記第1領域とは異なる第2領域から離れるように前記中心軸から偏倚しており、
前記外周部は、前記プランジャ封止部が前記円筒状の穴部に対して同軸となる状態において、前記円筒状の穴部に取り付けられる大きさおよび形状を有し、
前記遠位面が前記穴部の前記遠位壁の内面に対向した状態において前記プランジャ封止部が前記穴部の内部に取り付けられた際、前記内面の前記第2領域は、前記円筒状の穴部の前記中心軸に平行な方向において、前記第1領域よりも前記プランジャ封止部の前記遠位面に対して軸方向に近接している
医薬品用シリンジ。 - 前記内面の平均方位は、前記中心軸に対して傾いている
請求項1に記載の医薬品用シリンジ。 - 前記内面の前記平均方位は、約1度から約5度の範囲の角度となるように前記中心軸に対して傾いている
請求項2に記載の医薬品用シリンジ。 - 前記内面の前記第2領域は、前記プランジャ封止部の前記遠位面に対して軸方向に近接していることにより、前記遠位面が前記第1領域に接触する前に、前記プランジャの前記遠位面のうちの少なくとも40%に接触可能である
請求項1から請求項3のいずれか1項に記載の医薬品用シリンジ。 - 前記プランジャ封止部の前記遠位面は、凸形状を有する
請求項1から請求項4のいずれか1項に記載の医薬品用シリンジ。 - 前記内壁は、凹形状を有する
請求項5に記載の医薬品用シリンジ。 - 前記内壁は、円錐形状を有し、
前記内壁の開口角度は、前記プランジャ封止部の前記遠位面の前記凸形状の開口角度よりも小さい
請求項6に記載の医薬品用シリンジ。 - 前記内面は、放射対称性を有していない
請求項1から請求項7のいずれか1項に記載の医薬品用シリンジ。 - 前記内面の前記第1領域の平均方位は、前記プランジャ封止部が前記穴部に対して同軸となった際、前記プランジャ封止部の前記遠位面の平均方位から離れるように傾斜している
請求項1から請求項8のいずれか1項に記載の医薬品用シリンジ。 - 前記内壁の前記第2領域の平均方位は、前記プランジャ封止部が前記穴部に対して同軸となった際、前記プランジャ封止部の前記遠位面の平均方位に向かうように傾斜している
請求項1から請求項8のいずれか1項に記載の医薬品用シリンジ。 - 前記軸方向における近接は、前記プランジャの前記遠位面の平均外縁と前記第2領域の平均外縁との間の距離が前記プランジャの前記遠位面の前記平均外縁と前記第1領域の平均外縁との間の距離よりも小さいことを含む
請求項1から請求項10のいずれか1項に記載の医薬品用シリンジ。 - 前記内面の前記第1領域の表面と前記内面の前記第2領域の表面との間の推移は、連続的である
請求項1から請求項11のいずれか1項に記載の医薬品用シリンジ。 - 前記偏倚流体流出口を含む前記内壁の前記第1領域は、前記穴部の縁部に近接した位置に配置されており、
前記第2領域は、前記穴部の反対側の縁部に近接した位置に配置されている
請求項1から請求項12のいずれか1項に記載の医薬品用シリンジ。 - さらに、
前記偏倚流体流出口を起点とする屈曲流体路を備えた
請求項1から請求項13のいずれか1項に記載の医薬品用シリンジ。 - 近位開口部と、偏倚した位置に配置された遠位流体流出口とを有すると共に、プランジャ封止部を取り付ける円筒状の穴部を備えた医薬品用シリンジにおける流体のデッドスペースを減少させる方法であって、
前記円筒状の穴部の前記遠位端に向かって前記プランジャ封止部を駆動させる工程と、
前記偏倚流体流出口を含む領域とは異なる接触領域において、前記プランジャ封止部の遠位面の一部を前記穴部の前記遠位端の壁の内面の一部に接触させる工程と、
前記プランジャの前記遠位面の平均方位に対して傾いた平均方位に向かって流体を排出させながら、前記接触位置から前記偏倚流体流出口の位置に向かって接触範囲を拡大させる工程と、
を含む医薬品用シリンジにおける流体のデッドスペースを減少させる方法。 - 前記接触させる工程は、前記内面の周縁部である前記接触領域において最初に接触させることを含み、
前記周縁部は、前記偏倚流体流出口を含む前記領域とは異なっている
請求項15に記載の方法。 - 前記接触領域において接触させる工程は、前記偏倚流体流出口を含む前記領域に接触させる前に、前記プランジャの前記遠位面のうちの少なくとも40%に接触させることを含む
請求項15に記載の方法。 - 前記拡大させる工程は、前記周縁部から前記内壁の中心部を経由して前記偏倚流体流出口を含む前記領域まで前記接触範囲を拡大させることを含む
請求項15から請求項17のいずれか1項に記載の方法。 - 前記プランジャ封止部を弾性変形させることにより、前記接触範囲を拡大させる工程を行う
請求項15から請求項18のいずれか1項に記載の方法。 - 前記接触範囲を拡大させる工程は、前記偏倚流体流出口の前記位置に向かって前記接触位置から離れるように流体を流動させる
請求項15から請求項19のいずれか1項に記載の方法。 - さらに、
前記プランジャ封止部を駆動させる前記工程を終了させる工程
を含み、
約5Nと約25N徒の間の範囲の力により、前記プランジャ封止部を駆動させる前記工程を行う
請求項15から請求項20のいずれか1項に記載の方法。 - 前記終了させる工程を経たのち、前記プランジャ封止部と前記内壁との間における流体のデッドスペースの体積は、約0.01mlと約0.5mlとの間の範囲である
請求項21に記載の方法。
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JP2018535062A Active JP6633766B2 (ja) | 2015-10-09 | 2016-10-10 | 摺動可能な継手を有したパッチ型注射器 |
JP2018538527A Active JP6840761B2 (ja) | 2015-10-09 | 2016-10-10 | 注射針キャップおよび/またはライナ取り外し装置 |
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JP2018538525A Pending JP2018535068A (ja) | 2015-10-09 | 2016-10-10 | 流体路および駆動部を備えた注射装置 |
JP2021121212A Active JP7250858B2 (ja) | 2015-10-09 | 2021-07-26 | 流体路および駆動部を備えた注射装置 |
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EP (9) | EP3359231B1 (ja) |
JP (6) | JP6571878B2 (ja) |
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