WO2000025844A1 - Compact pump drive system - Google Patents

Compact pump drive system Download PDF

Info

Publication number
WO2000025844A1
WO2000025844A1 PCT/US1999/025414 US9925414W WO0025844A1 WO 2000025844 A1 WO2000025844 A1 WO 2000025844A1 US 9925414 W US9925414 W US 9925414W WO 0025844 A1 WO0025844 A1 WO 0025844A1
Authority
WO
WIPO (PCT)
Prior art keywords
piston
drive
reservoir
drive gear
axis
Prior art date
Application number
PCT/US1999/025414
Other languages
French (fr)
Inventor
Sheldon Moberg
Original Assignee
Minimed Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to US10623798P priority Critical
Priority to US60/106,237 priority
Application filed by Minimed Inc. filed Critical Minimed Inc.
Publication of WO2000025844A1 publication Critical patent/WO2000025844A1/en
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22310289&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2000025844(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/162Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/10Tube connectors; Tube couplings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/10Tube connectors; Tube couplings
    • A61M39/12Tube connectors; Tube couplings for joining a flexible tube to a rigid attachment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14244Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16831Monitoring, detecting, signalling or eliminating infusion flow anomalies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/162Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube
    • A61M2005/1623Details of air intake
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/10Tube connectors; Tube couplings
    • A61M2039/1033Swivel nut connectors, e.g. threaded connectors, bayonet-connectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/10Tube connectors; Tube couplings
    • A61M2039/1072Tube connectors; Tube couplings with a septum present in the connector
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/20Closure caps or plugs for connectors or open ends of tubes
    • A61M2039/205Closure caps or plugs for connectors or open ends of tubes comprising air venting means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/58Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/581Means for facilitating use, e.g. by people with impaired vision by audible feedback
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/58Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/582Means for facilitating use, e.g. by people with impaired vision by tactile feedback
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14566Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir for receiving a piston rod of the pump
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00Metal working
    • Y10T29/49Method of mechanical manufacture
    • Y10T29/49764Method of mechanical manufacture with testing or indicating
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00Metal working
    • Y10T29/49Method of mechanical manufacture
    • Y10T29/49826Assembling or joining
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00Metal working
    • Y10T29/53Means to assemble or disassemble

Abstract

An improved pump is provided for controlled delivery of fluids wherein the pump includes a reservoir and a movable piston. A plunger slide is in removable contact with the movable piston. A motor is operably coupled to a drive member, such as a drive screw. The motor is disposed in-line with the drive member and the plunger slide. The drive member is operably connected to the plunger slide and is disposed to be substantially enclosed by the plunger slide when the plunger slide is in at least one position. The drive member is adapted to advance the plunger slide in response to operation of the motor.

Description

COMPACT PUMP DRIVE SYSTEM

This application claims priority from provisional patent application no. 60/106,237, filed October 29, 1998 and U.S. patent application no. 09/xxx,xxx (attorney docket 0059- 0286) filed October 28, 1999, which are specifically incorporated herein by reference.

BACKGROUND OF THE INVENTION

1. Field of the Invention

This invention relates generally to improvements in infusion pumps such as those used for controlled delivery of medication to a patient. More specifically, this invention relates to an improved infusion pump having a modified and space-efficient drive system..

2. Description of the Related Art

Infusion pump devices and systems are relatively well-known in the medical arts, for use in delivering or dispensing a prescribed medication such as insulin to a patient. In one form, such devices comprise a relatively compact pump housing adapted to receive a syringe or reservoir carrying a prescribed medication for administration to the patient through infusion tubing and an associated catheter or infusion set.

The infusion pump includes a small drive motor connected via a lead screw assembly for motor-driven advancement of a reservoir piston to administer the medication to the user. Programmable controls can operate the drive motor continuously or at periodic intervals to obtain a closely controlled and accurate delivery of the medication over an extended period of time. Such infusion pumps are utilized to administer insulin and other medications, with exemplary pump constructions being shown and described in U.S. Patent Nos. 4,562,751; 4,678,408; 4,685,903; 5,080,653 and 5,097,122, which are incorporated by reference herein.

Infusion pumps of the general type described above have provided significant advantages and benefits with respect to accurate delivery of medication or other fluids over an extended period of time. The infusion pump can be designed to be extremely compact as well as water resistant, and may thus be adapted to be carried by the user, for example, by means of a belt clip or the like. As a result, important medication can be delivered to the user with precision and in an automated manner, without significant restriction on the user's mobility or life-style, including in some cases the ability to participate in water sports.

These pumps often incorporate a drive system which uses a lead screw coupled to motors. The motors can be of the DC, stepper or solenoid varieties. These drive systems provide an axial displacement of the syringe or reservoir piston thereby dispensing the medication to the user. Powered drive systems are advantageous since they can be electronically controlled to deliver a predetermined amount of medication by means well known in the art.

In the operation of these pump systems, the reservoir piston will be fully advanced when virtually all of the fluid in the reservoir has been dispensed. Correspondingly, the axial displacement of the motor lead screw is also typically fully displaced. In order to insert a new reservoir which is full of fluid, it is necessary to restore the lead screw to its original position. Thus the lead screw will have to be rewound or reset.

DC motors and stepper motors are advantageous over solenoid motors in that the former are typically easier to operate at speeds that allow rewinding the drive system electronically. Solenoid based drive systems, on the other hand, often must be reset manually, which in turn makes water resistant construction of the pump housing more difficult.

Lead screw drive systems commonly use several gears which are external to the motor. FIG. 1 shows such a lead screw arrangement which is known in the art. A motor 101 drives a lead screw 102 which has threads which are engaged with a drive nut 103. Thus the rotational force of the lead screw 102 is transferred to the drive nut 103 which causes it to move in an axial direction d. Because the drive nut 103 is fixably attached to a reservoir piston 104, it likewise will be forced in an axial direction d , parallel to direction d, thus dispensing the fluid from the reservoir 105 into the infusion set 106. The entire assembly can be contained in a water resistant housing 107.

FIG. 2 shows a different lead screw arrangement which also is known in the art. In this arrangement, a motor 201 (or a motor with an attached gear box) has a drive shaft 201a which drives a set of gears 202. The torque is then transferred from the gears 202 to a lead screw 203. The threads of the lead screw 203 are engaged with threads [not shown] in a plunger slide 204. Thus the torque of the lead screw 203 is transferred to the slide 204 which causes it to move in an axial direction d", parallel to the drive shaft 201a of the motor 201. The slide 204 is in contact with a reservoir piston 205 which likewise will be forced to travel in the axial direction d" thus dispensing fluid from the reservoir 206 into the infusion set 207. The assembly can be contained in a water resistant housing 208.

As previously noted, these lead screw drive systems use gears which are external to the motor. The gears are in combination with a lead screw with external threads which is used to drive the reservoir's piston. This external arrangement occupies a substantial volume which can increase the overall size of the pump. Moreover, as the number of drive components, such as gears and lead screw, increases, the torque required to overcome inherent mechanical inefficiencies can also increase. As a result, a motor having sufficient torque also often has a consequent demand for increased electrical power. Yet another known drive is depicted in FIGs. 3a and 3b. A reservoir 301 fits into the unit's housing 302. Also shown are the piston member 303 which is comprised of an elongated member with a substantially circular piston head 304 for displacing the fluid in the reservoir 301 when driven by the rotating drive screw 305 on the shaft (not visible) of the drive motor 306. As is more clearly shown in FIG. 3b, the reservoir 301, piston head 304 and piston member 303 comprise an integrated unit which is placed into the housing 302 (FIG. 3a). The circular piston head 304 displaces fluid in the reservoir upon axial motion of the piston member 303. The rearward portion of the piston member 303 is shaped like a longitudinal segment of a cylinder as shown in FIG. 3b and is internally threaded so that it may be inserted into a position of engagement with the drive screw 305. The drive screw

305 is a threaded screw gear of a diameter to mesh with the internal threads of the piston member 303. Thus the motor 306 rotates the drive screw 305 which engages the threads of the piston member 303 to displace the piston head 304 in an axial direction d.

While the in-line drive system of FIG. 3 a achieves a more compact physical pump size, there are problems associated with the design. The reservoir, piston head and threaded piston member constitute an integrated unit. Thus when the medication is depleted, the unit must be replaced. This results in a relatively expensive disposable item due to the number of components which go into its construction.

Moreover the design of FIG. 3 a is not water resistant. Because the reservoir, piston head and threaded piston member are removable, the drive screw 305 and motor 306 are exposed to the atmosphere. Any water which might come in contact with the drive screw 305 and motor 306 will result in corrosion and probable motor failure.

The design of FIG. 3a further gives rise to problems associated with position detection of the piston head 304. The piston member 303 can be decoupled from the drive screw 305. However, when another reservoir assembly is inserted, it is not known by the system whether the piston head 304 is in the fully retracted position or in some intermediate position. Complications therefore are presented with respect to providing an ability to electronically detect the position of the piston head 304 in order to determine the extent to which the medication in reservoir 301 has been depleted.

The construction of pumps to be water resistant give rise to operational problems. As the user travels from various elevations, such as might occur when traveling in an air plane, or as the user engages in other activities which expose the pump to changing atmospheric pressures, differential pressures can arise between the interior of the air tight/water-resistant pump housing and the atmosphere. Should the pressure in the housing exceed external atmospheric pressure, the resulting forces could cause the reservoir piston to be driven inward thus delivering unwanted medication. Thus it is desirable to have an improved, compact, water resistant drive system which permits safe user activity among various atmospheric pressures. Moreover it is desirable that such a system employ inexpensive medication reservoirs.

SUMMARY OF THE PREFERRED EMBODIMENTS

An improved pump is provided with a reservoir for accommodation of a liquid and a movable piston for varying the size of the reservoir and adapted to discharge the liquid from the reservoir through the outlet. In a certain aspect of the present inventions, a plunger slide is releasably coupled with the movable piston and has at least two positions. A driving device, such as a motor, is operably coupled to a drive member, such as a drive screw. The motor is disposed in-line with the drive screw and the plunger slide. The drive screw is operably connected to the plunger slide and is disposed to be substantially enclosed by the plunger slide when it is in at least one position. The drive screw is adapted to advance the plunger slide in response to operation of the motor. In one alternative, a housing for the reservoir, the movable piston, the plunger slide, the drive screw and the motor is provided along with a sealing device, such as an O- ring, that separates the portion of the housing which encloses the movable piston from the portion of the housing which encloses the drive screw and the motor.

In another preferred embodiment, a coupler is attached to the plunger slide. The coupler is removably attached to the movable piston to prevent separation of the movable piston from the plunger slide when the air pressure in the housing exceeds the pressure external to the water resistant housing. In still another embodiment, the housing includes a vent port between the exterior and interior of the housing. The vent port contains a hydrophobic material or a relief valve, either of which will permit air to pass through the vent, but will prevent water from passing.

In another alternative, the driving device is a motor which is attached to the housing with a compliance mount. In another embodiment, the plunger slide comprises a telescoping lead screw formed from at least two segments.

In yet another embodiment , the pump includes a key which is coupled with the plunger slide and which is operable to permit movement of the plunger slide in the direction of the at least two positions but prevent movement of the plunger slide in any other direction.

BRIEF DESCRIPTION OF THE DRA WINGS

FIG. 1 is a side plan view of a conventional lead-screw drive mechanism. FIG.2 is a side plan view of a another conventional lead-screw drive mechanism.

FIG. 3 a is a perspective view of another conventional lead-screw drive mechanism. FIG. 3b shows the details of a disposable reservoir with the piston and drive member withdrawn of the lead-screw drive mechanism of FIG. 3a.

FIG. 4 is a side plan, cut-away view of a drive mechanism in a retracted position in accordance with an embodiment of the present invention.

FIG. 5 is a perspective view of the in-line drive mechanism of FIG. 4 outside of the housing.

FIG. 6 is a cut-away perspective view of the drive mechanism of FIG. 4 in a retracted position. FIG. 7a is a side plan, cut-away view of the drive mechanism of FIG. 4 in an extended position.

FIG. 7b is a cut-away perspective view of the drive mechanism of FIG. 4 in an extended position.

FIG. 8 is a cut-away perspective view of an anti-rotation device for use with the drive mechanism shown in FIG. 4.

FIG. 9 is a cross-sectional view of a segmented (or telescoping) lead screw in accordance with an embodiment of the present invention. FIGs 10a, 10b and 10c are cross-sectional views of various embodiments of venting ports for use with the drive mechanism of FIG. 4.

FIG. 11 is a partial, cross-sectional view of a reservoir and plunger slide assembly.

FIG. 12 is a partial, cross sectional view of a reservoir and a reservoir connector.

FIGs. 13a and 13b are plunger slide force profile diagrams.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

In the following description, reference is made to the accompanying drawings which form a part hereof and which illustrate several embodiments of the present inventions. It is understood that other embodiments may be utilized and structural and operational changes may be made without departing from the scope of the present inventions.

As shown in the drawings for purposes of illustration, some aspects of the present inventions are directed to a drive mechanism for an infusion pump for medication or other fluids. In preferred embodiments, a releasable coupler couples an in-line drive to a plunger or piston of a reservoir to dispense fluids, such as medications, drugs, vitamins, vaccines, hormones, water or the like. However, it will be recognized that further embodiments of the invention may be used in other devices that require compact and accurate drive mechanisms. In addition, other embodiments use a telescoping drive member (or lead screw) to minimize the packaging dimensions of the drive mechanism and the overall configuration of the medication pump. Still further, a ventilation feature using hydrophobic materials or a relief valve can be employed to equalized any pressure differentials which might otherwise exist between the atmosphere and the interior of the pump housing. As a back up to this ventilation feature, a threaded attachment permits a secure coupling between the reservoir piston and the in-line drive.

FIG. 4 shows a side plan, cut-away view of an infusion pump drive mechanism according to a preferred embodiment of the inventions, in which a housing 401, containing a lower section 402 for a power supply 420 and electronic control circuitry 422, accommodates a driving device, such as a motor 403 (e.g., a solenoid, stepper or d.c. motor), a first drive member, such as an externally threaded drive gear or screw 404, a second drive member, such as an internally threaded plunger gear or slide 405, and a removable vial or reservoir 406. The reservoir 406 includes a plunger or piston 407 with O-rings or integral raised ridges for forming a water and air tight seal. The reservoir 406 is secured into the housing 401 with a connector 431 which also serves as the interface between the reservoir 406 and the infusion set tubing (not shown). In a preferred embodiment, the reservoir piston 407 is coupled to the plunger slide 405 by a releasable coupler. In the illustrated embodiment, the coupler includes a female portion 424 which receives a male portion 426 carried by the plunger slide 405. The female portion 424 is positioned at the end face 428 of the piston 407 and includes a threaded cavity which engages the threads of a male screw extending from the end 430 of the plunger slide 405. While preferred embodiments of the present inventions are directed to disposable, pre-filled reservoirs, alternative embodiments may use refillable cartridges, syringes or the like. The cartridge can be pre-filled with insulin (or other drug or fluid) and inserted into the pump. Alternatively, the cartridge could be filled by the user using an adapter handle on the syringe-piston. After being filled, the handle is removed (such as by unscrewing the handle) so that the cartridge can be placed into the pump. Referring again to FIG. 4, as the drive shaft 432 of the motor 403 rotates, the drive screw 404 drives the plunger slide 405 directly to obtain the axial displacement against the reservoir piston 407 to deliver the predetermined amount of medication or liquid. When using a DC or stepper motor, the motor can be rapidly rewound when the reservoir is emptied or as programmed by the user. A sealing device, such as an O-ring seal 409 is in contact with the plunger slide 405 thus allowing it to move axially while maintaining a water resistant barrier between the cavity holding the reservoir 406 and the motor 403. This prevents fluids and other contaminants from entering the drive system.

An anti-rotation key 410 is affixed to the plunger slide 405 and is sized to fit within a groove (not shown) axially disposed in the housing 401. This arrangement serves to prevent motor and plunger slide rotation which might otherwise result from the torque generated by the motor 403 in the event that the friction of the O-ring seal 409 is not sufficient alone to prevent rotation. The motor 403 is a conventional motor, such as a DC or stepper motor, and is journal mounted in the housing 401 by a system compliance mounting 412. A system compliance mount can be useful in aiding motor startup. Certain types of motors, such as stepper motors, may require a great deal of torque to initiate rotor motion when the rotor's initial at-rest position is in certain orientations with respect to the motor's housing. A motor which is rigidly mounted may not have enough power to develop the necessary starting torque. Including system compliance mounting permits the motor housing to turn slightly in response to high motor torque. This alters the orientation between the rotor and the housing such that less torque is required to initiate rotor motion. A compliance mount can include a rubberized mounting bracket. Alternatively, the mounting could be accomplished using a shaft bearing and leaf spring or other known compliance mountings. FIG. 5 shows a perspective view of the in-line drive mechanism of FIG. 4 outside of the housing. The plunger slide 405 (internal threads not shown) is cylindrically shaped and has the screw-shaped male portion 426 of the coupler attached to one end thereof. The anti-rotation key 410 is affixed to the opposite end of the slide 405. The drive screw 404 is of such a diameter as to fit within and engage the internal threads of the plunger slide 405 as shown in FIG. 4. A conventional gear box 501 couples the drive screw 404 to the drive shaft 432 of the motor 403.

FIGs. 4 and 6 show the infusion pump assembly with the plunger slide 405 in the retracted position. The reservoir 406 which may be full of medication or other fluid is inserted in a reservoir cavity 601 which is sized to receive a reservoir or vial. In the retracted position, the plunger slide 405 encloses the gear box 501 (not visible in Fig. 6) while the drive screw 404 (not visible in FIG. 6) remains enclosed within the plunger slide 405 but is situated close to the coupler.

The motor 403 may optionally include an encoder (not shown) which in conjunction with the system electronics can monitor the number of motor rotations. This in turn can be used to accurately determine the position of the plunger slide 405 thus providing information relating to the amount of fluid dispensed from the reservoir 406.

FIGs. 7a and 7b show the infusion pump assembly with the plunger slide 405 in the fully extended position. In this position, the plunger slide 405 has withdrawn from over the gear box 501 and advanced into the reservoir 406 behind the reservoir piston 407.

Accordingly, the plunger slide 405 is sized to fit within the housing of the reservoir 406, such that when the reservoir piston 407 and the plunger slide 405 are in the fully extended position as shown, the reservoir piston 407 has forced most, if not all, of the liquid out of the reservoir 406. As explained in greater detail below, once the reservoir piston 407 has reached the end of its travel path indicating that the reservoir has been depleted, the reservoir 406 may be removed by twisting such that the threaded reservoir piston 407 (not shown in Fig. 7b) disengages from the male portion 426 of the coupler. In a preferred embodiment, the motor drive shaft 432, gear box 5 1 , drive screw

404, and plunger slide 405 are all coaxially centered within the axis of travel 440 (FIG. 4) of the reservoir piston 407. In certain of the alternative embodiments, one or more of these components may be offset from the center of the axis of travel 440 and yet remain aligned with the axis of travel which has a length which extends the length of the reservoir 406. FIG. 8 is a cut away perspective view of an anti-rotation device. The anti-rotation key 410 consists of a ring or collar 442 with two rectangular tabs 436 which are spaced 180° apart. Only one tab is visible in FIG. 8. The ring portion 442 of the key 410 surrounds and is attached to the end of the plunger slide 405 which is closest to the motor. Disposed in the housing 401 are two anti -rotation slots 434, only one of which is visible in FIG. 8. The anti-rotation slots 434 are sized to accept the rectangular tabs of the key

410. As the plunger slide 405 moves axially in response to the motor torque as previously described, the slots 434 will permit the key 410 to likewise move axially. However the slots 434 and the tabs 436 of the key 410 will prevent any twisting of the plunger slide 405 which might otherwise result from the torque generated by the motor. FIG. 9 illustrates a split lead-screw (or plunger slide) design in accordance with an embodiment of the present inventions. The use of a split lead-screw or telescoping lead screw allows the use of an even smaller housing for the drive mechanism. A telescoping lead-screw formed from multiple segments allows the pump to minimize the dimensions of the drive mechanism, in either in-line or gear driven drive mechanisms. In preferred embodiments, an interior shaft 901 is rotated by a gear 906 which is coupled to a drive motor (not shown). This in turn extends a middle drive segment 902 by engaging with the threads of an internal segment 904. The middle segment 902 carries an outer segment 903 forward with it in direction d as it is extended to deliver fluid. When the middle segment 902 is fully extended, the internal segment 904 engages with a stop 905 on the middle segment 902 and locks it down from pressure with the threads between the middle and internal segments. The locked middle segment 902 then rotates relative to the outer segment 903 and the threads between the middle segment 902 and the outer segment 903 engage to extend the outer segment 903 in direction d to its full length.

The use of multiple segments is not limited to two or three segments; more may be used. The use of three segments reduces the length of the retracted lead-screw portion of the drive mechanism by half. In alternative embodiments, the outer segment may be connected to the motor and the inner segment may be the floating segment. In preferred embodiments, O-rings 907 are used to seal each segment relative to the other and to form a seal with the housing to maintain water sealing and integrity.

As previously noted, the construction of these pumps to be water resistant can give rise to operational problems. As the user engages in activities which expose the pump to varying atmospheric pressures, differential pressures can arise between the interior of the air tight/water-resistant housing and the atmosphere. Should the pressure in the housing exceed external atmospheric pressure, the resulting forces could cause the reservoir piston to be driven inward thus delivering unwanted medication. On the other hand, should the external atmospheric pressure exceed the pressure in the housing, then the pump motor will have to work harder to advance the reservoir piston. To address this problem, a preferred embodiment of the inventions includes a venting port which resists the intrusion of moisture. Referring to FIG. 7b, venting is accomplished through the housing 401 into the reservoir cavity 601 via a vent port 605. The vent port can be enclosed by a relief valve (not shown) or covered with hydrophobic material. Hydrophobic material permits air to pass through the material while resisting the passage of water or other liquids from doing so, thus permitting water resistant venting.

The preferred embodiment uses a hydrophobic material such as Gore-Tex® , PTFE, HDPE, UHMW polymers from sources such as W.I. Gore & Associates, Flagstaff, AZ, Porex Technologies, Fairburn, GA, or DeWAL Industries, Saunderstown, RI. It is appreciated that other hydrophobic materials may be used as well. These materials are available in sheet form or molded (press and sintered) in a geometry of choice. Referring to FIGs 10a - 10c, preferred methods to attach this material to the housing 401 include molding the hydrophobic material into a sphere 1001 (FIG. 10a) or a cylinder 1002 (FIG. 10b) and pressing it into a cavity in the pre-molded plastic housing. Alternatively, a label 1003 (FIG. 10c) of this material could be made with either a transfer adhesive or heat bond material 1004 so that the label could be applied over the vent port 605. Alternatively, the label could be sonically welded to the housing. In either method, air will be able to pass freely, but water will not. In an alternative embodiment (not shown), the vent port could be placed in the connector 431 which secures the reservoir 406 to the housing 401 and which also serves to secure and connect the reservoir 406 to the infusion set tubing (not shown). As described in greater detail in copending application Serial No. , filed contemporaneously herewith (Attorney docket No. 0059-0307), which application is incorporated by reference in its entirety, the connector and infusion set refers to the tubing and apparatus which connects the outlet of the reservoir to the user of a medication infusion pump.

An advantage of placing the vent port and hydrophobic material in this location, as opposed to the housing 401, is that the infusion set is disposable and is replaced frequently with each new reservoir or vial of medication. Thus new hydrophobic material is frequently placed into service. This provides enhanced ventilation as compared with the placement of hydrophobic material in the housing 401. Material in this location will not be replaced as often and thus is subject to dirt or oil build up which will retard ventilation. In yet another alternative embodiment however, vent ports with hydrophobic material could be placed in both the pump housing and in the connector portion of the infusion set. Regardless of the location of the vent port, there remains the possibility that the vent port can become clogged by the accumulation of dirt, oil, etc. over the hydrophobic material. In another feature of certain embodiments of the present invention, the releasable coupler can act to prevent unintentional medication delivery in those instances when the internal pump housing pressure exceeds atmospheric pressure. Referring to FIG. 11 , the coupler includes threads formed in a cavity within the external face of the reservoir piston

407. The threaded cavity 424 engages the threads of the male portion 426 which in turn is attached to the end 430 of the plunger slide 405.

This thread engagement reduces or prevents the effect of atmospheric pressure differentials acting on the water resistant, air-tight housing 401 (not shown in FIG. 11) from causing inadvertent fluid delivery. The threads of the male portion 426 act to inhibit or prevent separation of the reservoir piston 407 from the plunger slide 405 which, in turn, is secured to the drive screw 404 (not shown in FIG. 11) by engagement of the external threads of the drive screw 404 with the internal threads of the plunger slide 405. As a result, the coupler resists movement of the reservoir piston 407 caused by atmospheric pressure differentials.

When the reservoir 406 is to be removed, it is twisted off of the coupler male portion 426. The system electronics then preferably cause the drive motor 403 to rapidly rewind so that the plunger slide 405 is driven into a fully retracted position (FIGs. 4 and 6).

A new reservoir 406, however, may not be full of fluid. Thus the reservoir piston 407 may not be located in the furthest possible position from the reservoir outlet. Should the reservoir piston 407 be in such an intermediate position, then it may not be possible to engage the threads of the male portion 426 of the coupler (which is in a fully retracted position) with those in the female portion 424 of the coupler in the reservoir piston 407 upon initial placement of the reservoir.

In accordance with another feature of certain embodiments, the illustrated embodiment provides for advancement of the plunger slide 405 upon the insertion of a reservoir into the pump housing. The plunger slide 405 advances until it comes into contact with the reservoir piston 407 and the threads of the coupler male portion 426 of the coupler engage the threads in the female portion 424 in the reservoir piston 407. When the threads engage in this fashion in the illustrated embodiment, they do so not by twisting. Rather, they rachet over one another.

In the preferred embodiment, the threads of the coupler male portion 426 have a 5 start, 40 threads per inch ("TPI") pitch or profile while the threads of the coupler female portion 424 have a 2 start, 40 TPI pitch or profile as illustrated in FIG. 11. Thus these differing thread profiles do not allow for normal tooth-to-tooth thread engagement. Rather, there is a cross threaded engagement.

The purpose of this intentional cross threading is to reduce the force necessary to engage the threads as the plunger slide 405 seats into the reservoir piston 407. In addition, the 2 start, 40 TPI threads of the coupler female portion 424 are preferably made from a rubber material to provide a degree of compliance to the threads. On the other hand, the 5 start, 40 TPI threads of the male coupler portion 426 are preferably made of a relatively hard plastic. Other threading arrangements and profiles could be employed resulting in a similar effect.

If on the other hand, the threads had a common thread pitch with an equal number of starts given the same degree of thread interference (i.e., the OD of the male feature being larger than the OD of the female feature), then the force needed to insert the male feature would be pulsatile. Referring to FIG. 13a, as each thread tooth engages the next tooth, the insertion force would be high as compared to the point where the thread tooth passes into the valley of the next tooth. But with the cross threaded arrangement of the preferred embodiment, not all of the threads ride over one another at the same time. Rather, they ratchet over one another individually due to the cross-threaded profile. This arrangement results in less force required to engage the threads when the plunger slide moves axially, but still allows the reservoir to easily be removed by a manual twisting action.

While the advantage of utilizing a common thread pitch would be to provide a maximum ability to resist axial separation of the reservoir piston 407 from the plunger slide 405, there are disadvantages. In engaging the threads, the peak force is high and could result in excessive delivery of fluids as the plunger slide 405 moves forward to seat in the cavity of the reservoir piston 407. As described in greater detail in copending application Serial No. , filed contemporaneously herewith (Attorney Docket No. 0059-0308), which application is incorporated by reference in its entirety, the pump may have an occlusion detection system which uses axial force as an indicator of pressure within the reservoir. If so, then a false alarm may be generated during these high force conditions.

Therefore, the insertion force profile is preferably more flat than that shown in FIG. 13a. To accomplish this, the cross threading design of the preferred embodiment causes the relatively soft rubber teeth of the female portion 424 at the end of the reservoir piston 407 to rachet or swipe around the relatively hard plastic teeth of the coupler resulting in a significantly lower insertion force for the same degree of thread interference. (See FIG. 13b) This is due to the fact that not all of the thread teeth ride over one another simultaneously. Moreover, the cross-sectional shape of the threads are ramped. This makes it easier for the threads to ride over one another as the plunger slide is being inserted into the reservoir piston. However, the flat opposite edge of the thread profile makes it much more difficult for the plunger slide to be separated from the reservoir piston. Referring to FIGs. 11 and 12, the 5 start, 40 TPI (0.125" lead) thread profile of the coupler male portion 426 was chosen in consideration of the thread lead on the preferred embodiment of the connector 431. The connector 431 is secured into the pump housing with threads 433 (FIG. 7b) having a 2 start, 8 TPI (0.250" lead) profile. Therefore the 0.250" lead on the connector is twice that of the reservoir piston 407 which is 0J25". This was chosen to prevent inadvertent fluid delivery during removal of the reservoir from the pump housing, or alternatively, to prevent separation of the reservoir piston 407 from the reservoir 406 during removal from the pump housing. When the connector 431 is disengaged from the pump, the connector 431 as well as the reservoir 406 will both travel with the 0.250" lead. Since the threaded coupler lead is 0J25", the plunger slide 405 will disengage somewhere between the 0J25" lead of the threaded coupler and the 0.250" lead of the infusion set 1103. Therefore, the rate that the reservoir piston 407 is removed from the pump is the same down to half that of the reservoir 406/connector 431. Thus any medication which may be present in the reservoir 406 will not be delivered to the user. Additionally, the length of the reservoir piston 407 is sufficient such that it will always remain attached to the reservoir 406 during removal from the pump. Although the preferred embodiment describes the plunger slide 405 having a coupler male portion 426 with an external thread lead that is different from the connector 431, this is not necessary. The thread leads could be the same or of an increment other than what has been described. The 2 start thread profile of the coupler female portion 424 on the reservoir piston 407 of the preferred embodiment provides another advantage. Some versions of these reservoirs may be designed to be filled by the user. In such an instance, a handle (not shown) will need to be screwed into the threaded portion of the reservoir piston 407 in order for the user to retract the reservoir piston 407 and fill the reservoir. The number of rotations necessary to fully insert the handle depends upon the distance the handle thread profile travels to fully engage the reservoir piston 407 as well as the thread lead.

For example, a single start, 40 TPI (0.025" lead) thread requires 4 complete rotations to travel a 0J0" thread engagement. However, a 2 start, 40 TPI (0.050" lead) thread only requires 2 complete rotations to travel the 0J0" thread engagement.

Therefore, an additional advantage of a 2 start thread as compared to a single start thread (given the same pitch) is that half as many rotations are needed in order to fully seat the handle.

In alternative embodiments which are not shown, the end of the plunger slide 405 may include a detente or ridge to engage with a corresponding formation in the reservoir piston 407 to resist unintended separation of the plunger slide 405 from the reservoir piston 407. In other embodiment--, the plunger slide 405 is inserted and removed by overcoming a friction fit. Preferably, the friction fit is secure enough to resist movement of the reservoir piston 407 relative to the plunger slide 405 due to changes in air pressure, but low enough to permit easy removal of the reservoir 406 and its reservoir piston 407 from the plunger slide 405 once the fluid has been expended. In other embodiments, the detente or ridge may be spring loaded or activated to grasp the reservoir piston 407 once the drive mechanism has been moved forward (or extended), but is retracted by a switch or cam when the drive mechanism is in the rearmost (or retracted) position. The spring action could be similar to those used on collets. In other embodiments of the inventions, the threaded coupler may be engaged with the threaded cavity of the reservoir piston by twisting or rotating the reservoir as it is being manually placed into the housing. As set forth above, the reservoir piston 407 is made of rubber. In the illustrated embodiment, an insert 1201 (FIG. 12) which is made of hard plastic may provided in the upper portion of the reservoir piston 407. The insert 1201 provides stiffness to the rubber reservoir piston 407. This reduces undesirable compliance which is associated with the reservoir. Without the insert 1201, the flexibility in the reservoir piston 407 due to its rubber composition could cause it to deform under varying reservoir fluid back pressures. This deformation could in turn vary the internal volume of the reservoir 406. Such variances may adversely affect the controlled delivery of the fluid from the reservoir 406 via the infusion set to the user.

It can be appreciated that the design of FIGs. 4-12 results in an arrangement where the plunger slide 405 is reliably but releasably coupled to the drive screw 404. When it is time to replace the reservoir 406, it can be detached from the male end of the coupler without affecting the plunger/drive screw engagement. Moreover in the preferred embodiment, the plunger slide 405 is shaped as a hollow cylinder with internal threads. Thus it completely encircles and engages drive screw 404. When the plunger slide 405 is in a relatively retracted position, it encloses any gears which couple the motor 403 with the drive screw 404 thus achieving an extremely compact design. Alternative embodiments include an arrangement where the plunger slide 405 encloses the motor 403 itself. A vent port covered with hydrophobic material as well as a threaded coupler provide redundant means for permitting exposure of the pump to changing atmospheric pressures without the unintended delivery of medication.

While the description above refers to particular embodiments of the present inventions, it will be understood that many modifications may be made without departing from the spirit thereof. The accompanying claims are intended to cover such modifications as would fall within the true scope and spirit of the present inventions. The presently disclosed embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the inventions being indicated by the appended claims rather than the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.

Claims

WHAT IS CLAIMED IS:
1. A portable medical device for dispensing liquid from a liquid reservoir having a piston which defines an axis of travel, the medical device comprising: a drive motor having a rotating drive shaft which defines an axis of rotation, said drive shaft axis of rotation being coaxially aligned with the piston axis of travel; a linear actuator adapted to linearly actuate the reservoir piston along the piston axis of travel in response to rotation of the drive motor drive shaft; and a releasable coupler adapted to releasably couple the linear actuator to the piston.
2. A portable medical device for dispensing liquid from a liquid reservoir having a piston which defines an axis of travel, the medical device comprising: a drive motor having a rotating drive shaft which defines an axis of rotation, said drive shaft axis of rotation being coaxially aligned with the piston axis of travel; a first drive gear positioned to be rotatably actuated by the drive motor drive shaft, said first drive gear having internal threads; a second drive gear having external threads positioned to be engaged by the first drive gear internal threads and linearly actuated by rotation of the first drive gear threads; and a releasable coupler adapted to releasably couple the second drive gear to the reservoir piston wherein linear actuation of the second drive gear linearly actuates the piston.
3. A portable medical device for dispensing liquid from a liquid reservoir having a piston which defines an axis of travel, the medical device comprising: a drive motor having a rotating drive shaft which defines an axis of rotation, said drive shaft axis of rotation being coaxially aligned with the piston axis of travel; a first drive gear positioned to be rotatably actuated by the drive motor drive shaft, said first drive gear having external threads; a second drive gear having internal threads positioned to be engaged by the first drive gear external threads and linearly actuated by rotation of the first drive gear threads; and a releasable coupler adapted to releasably couple the second drive gear to the reservoir piston wherein linear actuation of the second drive gear linearly actuates the reservoir piston.
4. The medical device of claim 3 wherein the second drive gear defines a cavity and the second drive gear internal threads encircle the second drive gear cavity.
5. The medical device of claim 3 wherein the releasable coupler includes a first threaded member carried by the second drive gear and a second threaded member is carried by the reservoir piston and adapted to engage the first threaded member.
6. The medical device of claim 5 wherein the first threaded member comprises a screw extending from the second drive gear and having external threads, and the second threaded member comprises a cavity defined by the reservoir piston and having internal threads positioned to be engaged by the screw external threads.
7. The medical device of claim 6 wherein the external threads of the screw are made of a material having a first hardness and the internal threads of the piston cavity are made of a material having a second hardness.
8. The medical device of claim 6 wherein the external threads of the screw have a first lead and wherein the internal threads of the piston cavity have a second lead.
9. The medical device of claim 4 further comprising a housing enclosing the drive motor, the first and second drive gears, the releasable coupler and the reservoir and wherein the housing further includes a vent port containing a hydrophobic material.
10. The medical device of claim 3 wherein the second drive gear comprises a telescoping lead screw formed from at least two segments.
11. A medical device for dispensing liquid from a liquid reservoir having a piston which defines an axis of travel, the medical device comprising: a drive motor having a rotating drive shaft which defines an axis of rotation, said drive shaft axis of rotation being coaxially aligned with the piston axis of travel; a first drive gear positioned to be rotatably actuated by the drive motor drive shaft, said first drive gear having external threads; a second drive gear having internal threads positioned to be engaged by the first drive gear external threads and linearly actuated by rotation of the first drive gear threads; and releasable coupler means for releasably coupling the second drive gear to the reservoir piston wherein linear actuation of the second drive gear linearly actuates the reservoir piston.
12. A portable medical device for dispensing liquid from a liquid reservoir having a piston, the medical device comprising: a first drive gear journaled for rotation and having external threads; a drive motor adapted to rotate the first drive gear; and a second drive gear adapted for linear movement and positioned to linearly actuate the reservoir piston, said second drive gear defining a cavity and having internal threads which encircle the second drive gear cavity, said internal threads being positioned to be engaged by the first drive gear external threads and to be linearly actuated by rotation of the first drive gear threads wherein the reservoir piston is linearly actuated by the second drive gear.
13. A method of dispensing liquid from a portable liquid reservoir having a piston which defines an axis of travel, the method comprising: coupling a first reservoir piston of a first reservoir to a linear actuator; rotating a motor drive shaft which defines an axis of rotation, said drive shaft axis of rotation being coaxially aligned with the piston axis of travel; linearly actuating the reservoir piston along the piston axis of travel using the linear actuator in response to rotation of the drive motor drive shaft to dispense the liquid from the reservoir; and releasing the first reservoir piston from the linear actuator.
14. The method of claim 13 further comprising coupling a second reservoir piston of a second reservoir to the linear actuator following releasing the first reservoir piston.
15. The method of claim 13 wherein the coupling includes driving a first threaded member carried by the linear actuator into engagement with a second threaded member carried by the reservoir piston.
16. The method of claim 15 wherein the first threaded member comprises a screw extending from the linear actuator and having external threads, and the second threaded member comprises a cavity defined by the piston and having internal threads positioned to be engaged by the screw external threads.
17. The method of claim 16 wherein the external threads of the screw are made of a material having a first hardness and the internal threads of the piston cavity are made of a material having a second hardness.
18. The method of claim 16 wherein the external threads of the screw have a first lead and wherein the internal threads of the piston cavity have a second lead.
19. The method of claim 15 wherein the releasing includes rotating the reservoir piston to unscrew the first threaded member from the second threaded member.
20. The method of claim 13 further comprising venting a housing enclosing the drive motor and linear actuator through a vent port containing a hydrophobic material.
21. A portable medical device for dispensing liquid from a liquid reservoir having a piston which defines an axis of travel, the medical device comprising: a first drive member; means for driving the first drive member, said driving means being coaxially aligned with the piston axis of travel; a second drive member coaxially aligned with the piston axis of travel; and means for linearly actuating the second drive member with the first drive member, wherein the linear actuation of the second drive member linearly actuates the piston.
22. The medical device of claim 21 further comprising means for releasably coupling the second drive member with the piston.
23. The medical device of claim 21 further comprising a housing enclosing the first and second drive members, the driving means and the linear actuating means, wherein the housing includes means for venting the housing to the atmosphere without permitting liquids to pass through said venting means.
PCT/US1999/025414 1998-10-29 1999-10-28 Compact pump drive system WO2000025844A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10623798P true 1998-10-29 1998-10-29
US60/106,237 1998-10-29

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2000579280A JP3546015B2 (en) 1998-10-29 1999-10-28 Compact and economical pump drive system
DE69923858T DE69923858T2 (en) 1998-10-29 1999-10-28 Compact pump drive system
AT99971335T AT289523T (en) 1998-10-29 1999-10-28 Compact pump drive system
EP99971335A EP1124600B1 (en) 1998-10-29 1999-10-28 Compact pump drive system
CA002345439A CA2345439C (en) 1998-10-29 1999-10-28 Compact pump drive system
AU14567/00A AU1456700A (en) 1998-10-29 1999-10-28 Compact pump drive system

Publications (1)

Publication Number Publication Date
WO2000025844A1 true WO2000025844A1 (en) 2000-05-11

Family

ID=22310289

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US1999/025414 WO2000025844A1 (en) 1998-10-29 1999-10-28 Compact pump drive system
PCT/US1999/025413 WO2000025852A1 (en) 1998-10-29 1999-10-28 Reservoir connector

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US1999/025413 WO2000025852A1 (en) 1998-10-29 1999-10-28 Reservoir connector

Country Status (9)

Country Link
US (14) US6585695B1 (en)
EP (6) EP1716884B1 (en)
JP (4) JP4267206B2 (en)
AT (3) AT289523T (en)
AU (2) AU1330500A (en)
CA (5) CA2669175C (en)
DE (3) DE69928827T2 (en)
DK (3) DK1124608T3 (en)
WO (2) WO2000025844A1 (en)

Cited By (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002051472A1 (en) * 2000-12-22 2002-07-04 Dca Design International Limited Drive mechanism for an injection device
EP1219312A3 (en) * 2000-12-29 2003-01-02 CANE' S.r.l. Portable apparatus for infusing drugs
EP1409063A1 (en) * 2001-07-03 2004-04-21 Syntheon, LLC. Methods and apparatus for sclerosing the wall of a varicose vein
FR2856929A1 (en) * 2003-07-03 2005-01-07 Olivetti S N C Di Olivetti E F Syringe for injecting a predetermined volume of liquid, useful in veterinary medicine and for injection of cadavers, includes an electromechanical device for controlling advance of the piston
EP1641516A2 (en) * 2003-06-09 2006-04-05 Nipro Diabetes Systems, Inc. Coupling system for an infusion pump
WO2008106806A1 (en) * 2007-03-02 2008-09-12 Tecpharma Licensing Ag Modular administration system
WO2010078073A1 (en) * 2008-12-30 2010-07-08 Medtronic Minimed, Inc. Reservoir compartment adapter for infusion device
WO2010102750A1 (en) * 2009-03-12 2010-09-16 Imp Pape Gmbh & Co. Kg Method and device for continuously driving a syringe plunger
EP2372590A1 (en) 2010-03-31 2011-10-05 F.Hoffmann-La Roche Ag Assembly station with component backtracking features
EP2371408A2 (en) 2010-03-31 2011-10-05 Roche Diagnostics GmbH Liquid drug degasing devise and ambulatory infusion system including a degasing device
EP2378119A1 (en) * 2010-04-15 2011-10-19 Mmi Ag Plunger pump with manual insertion possibility for volumes under a microlitre
WO2012019726A1 (en) 2010-08-07 2012-02-16 Roche Diagnostics Gmbh Valve for an ambulatory infusion system and ambulatory infusion system including a valve
EP2469432A1 (en) 2010-12-24 2012-06-27 F.Hoffmann-La Roche Ag Ambulatory infusion system with alert prioritizing features
WO2013010561A1 (en) 2011-07-20 2013-01-24 Roche Diagnostics Gmbh Drive control for an ambulatory infusion device
USD702834S1 (en) 2011-03-22 2014-04-15 Medimop Medical Projects Ltd. Cartridge for use in injection device
US8715268B2 (en) 2008-02-21 2014-05-06 Roche Diagnostics International Ag Administration device having a bolus administration profile controller
US8915882B2 (en) 2010-01-19 2014-12-23 Medimop Medical Projects Ltd. Needle assembly for drug pump
US9011164B2 (en) 2013-04-30 2015-04-21 Medimop Medical Projects Ltd. Clip contact for easy installation of printed circuit board PCB
EP2862586A1 (en) 2013-10-21 2015-04-22 F. Hoffmann-La Roche AG Control unit for infusion pump units, including a controlled intervention unit
EP2865325A1 (en) 2013-10-23 2015-04-29 F. Hoffmann-La Roche AG Skin-adherable cradle for infusion pump or continuous blood glucose monitor having optical indication means
US9072827B2 (en) 2012-03-26 2015-07-07 Medimop Medical Projects Ltd. Fail safe point protector for needle safety flap
US9173997B2 (en) 2007-10-02 2015-11-03 Medimop Medical Projects Ltd. External drug pump
US9259532B2 (en) 2010-01-19 2016-02-16 Medimop Medical Projects Ltd. Cartridge interface assembly
US9345836B2 (en) 2007-10-02 2016-05-24 Medimop Medical Projects Ltd. Disengagement resistant telescoping assembly and unidirectional method of assembly for such
US9421323B2 (en) 2013-01-03 2016-08-23 Medimop Medical Projects Ltd. Door and doorstop for portable one use drug delivery apparatus
CN105899246A (en) * 2014-01-13 2016-08-24 诺和诺德股份有限公司 Transmission arrangement for motorized drug delivery devic
US9452261B2 (en) 2010-05-10 2016-09-27 Medimop Medical Projects Ltd. Low volume accurate injector
US9572926B2 (en) 2009-09-15 2017-02-21 Medimop Medical Projects Ltd. Cartridge insertion assembly
US9656019B2 (en) 2007-10-02 2017-05-23 Medimop Medical Projects Ltd. Apparatuses for securing components of a drug delivery system during transport and methods of using same
US9987432B2 (en) 2015-09-22 2018-06-05 West Pharma. Services IL, Ltd. Rotation resistant friction adapter for plunger driver of drug delivery device
US10071198B2 (en) 2012-11-02 2018-09-11 West Pharma. Servicees IL, Ltd. Adhesive structure for medical device
US10071196B2 (en) 2012-05-15 2018-09-11 West Pharma. Services IL, Ltd. Method for selectively powering a battery-operated drug-delivery device and device therefor
US10149943B2 (en) 2015-05-29 2018-12-11 West Pharma. Services IL, Ltd. Linear rotation stabilizer for a telescoping syringe stopper driverdriving assembly
US10159786B2 (en) 2014-09-30 2018-12-25 Perqflo, Llc Hybrid ambulatory infusion pumps
US10272196B2 (en) 2010-09-24 2019-04-30 Perqflo, Llc Infusion pumps
US10293120B2 (en) 2015-04-10 2019-05-21 West Pharma. Services IL, Ltd. Redundant injection device status indication

Families Citing this family (321)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020173748A1 (en) 1998-10-29 2002-11-21 Mcconnell Susan Reservoir connector
US7193521B2 (en) * 1998-10-29 2007-03-20 Medtronic Minimed, Inc. Method and apparatus for detecting errors, fluid pressure, and occlusions in an ambulatory infusion pump
US7766873B2 (en) 1998-10-29 2010-08-03 Medtronic Minimed, Inc. Method and apparatus for detecting occlusions in an ambulatory infusion pump
US7063684B2 (en) * 1999-10-28 2006-06-20 Medtronic Minimed, Inc. Drive system seal
AT289523T (en) 1998-10-29 2005-03-15 Medtronic Minimed Inc Compact pump drive system
US7018401B1 (en) 1999-02-01 2006-03-28 Board Of Regents, The University Of Texas System Woven intravascular devices and methods for making the same and apparatus for delivery of the same
US6423035B1 (en) * 1999-06-18 2002-07-23 Animas Corporation Infusion pump with a sealed drive mechanism and improved method of occlusion detection
US6873268B2 (en) 2000-01-21 2005-03-29 Medtronic Minimed, Inc. Microprocessor controlled ambulatory medical apparatus with hand held communication device
GB0020060D0 (en) * 2000-08-16 2000-10-04 Smiths Industries Plc Syringe pumps
US7083597B2 (en) 2001-01-05 2006-08-01 Applied Diabetes Research, Inc. Pivoting joint infusion system with seal
US8343115B2 (en) * 2001-01-05 2013-01-01 Applied Diabetes Research, Inc. Low profile pivoting joint infusion assembly
US6685674B2 (en) 2001-03-04 2004-02-03 Sterling Medivations, Inc. Infusion hub assembly and fluid line disconnect system
WO2002094352A2 (en) 2001-05-18 2002-11-28 Deka Products Limited Partnership Infusion set for a fluid pump
US8034026B2 (en) 2001-05-18 2011-10-11 Deka Products Limited Partnership Infusion pump assembly
US8152789B2 (en) 2001-10-23 2012-04-10 Medtronic Minimed, Inc. System and method for providing closed loop infusion formulation delivery
US10080529B2 (en) 2001-12-27 2018-09-25 Medtronic Minimed, Inc. System for monitoring physiological characteristics
US8775196B2 (en) 2002-01-29 2014-07-08 Baxter International Inc. System and method for notification and escalation of medical data
US10173008B2 (en) 2002-01-29 2019-01-08 Baxter International Inc. System and method for communicating with a dialysis machine through a network
US8234128B2 (en) 2002-04-30 2012-07-31 Baxter International, Inc. System and method for verifying medical device operational parameters
US7232419B2 (en) * 2002-02-11 2007-06-19 Baxter International Inc. Enclosure with cam action snap release
US7033338B2 (en) * 2002-02-28 2006-04-25 Smiths Medical Md, Inc. Cartridge and rod for axially loading medication pump
US20030163089A1 (en) * 2002-02-28 2003-08-28 Bynum Gail Beth Child safety cap for syringe pump
US7041082B2 (en) * 2002-02-28 2006-05-09 Smiths Medical Md, Inc. Syringe pump control systems and methods
EP1490133B1 (en) 2002-03-08 2015-04-22 Applied Diabetes Research, Inc. Low profile, pivotal connection infusion assembly
US20030195609A1 (en) * 2002-04-10 2003-10-16 Scimed Life Systems, Inc. Hybrid stent
US7175606B2 (en) * 2002-05-24 2007-02-13 Baxter International Inc. Disposable medical fluid unit having rigid frame
US7530968B2 (en) 2003-04-23 2009-05-12 Valeritas, Inc. Hydraulically actuated pump for long duration medicament administration
WO2004098684A2 (en) * 2003-05-08 2004-11-18 Novo Nordisk A/S Skin mountable injection device with a detachable needle insertion actuation
EP1475113A1 (en) * 2003-05-08 2004-11-10 Novo Nordisk A/S External needle inserter
DE602004013140T2 (en) * 2003-05-08 2009-07-02 Novo Nordisk A/S internal nadeleinführvorrichtung
EP1502613A1 (en) * 2003-08-01 2005-02-02 Novo Nordisk A/S Needle device with retraction means
KR20060099520A (en) * 2003-10-21 2006-09-19 노보 노르디스크 에이/에스 Medical skin mountable device
US8540493B2 (en) * 2003-12-08 2013-09-24 Sta-Rite Industries, Llc Pump control system and method
EP1732626A1 (en) * 2004-03-30 2006-12-20 Novo Nordisk A/S Actuator system comprising lever mechanism
CA2561251A1 (en) * 2004-03-30 2005-10-13 Novo Nordisk A/S Actuator system comprising detection means
US8961461B2 (en) 2004-05-27 2015-02-24 Baxter International Inc. Multi-state alarm system for a medical pump
US9089636B2 (en) 2004-07-02 2015-07-28 Valeritas, Inc. Methods and devices for delivering GLP-1 and uses thereof
JP5100378B2 (en) * 2004-07-07 2012-12-19 ロナルド アラン グリーンベルグ For skin polishing hand tool assembly.
DE102004036106A1 (en) 2004-07-24 2006-03-16 Ina-Schaeffler Kg Periodically acted upon tappet for a valve or pump drive
US8469675B2 (en) 2004-08-26 2013-06-25 Pentair Water Pool And Spa, Inc. Priming protection
US8019479B2 (en) 2004-08-26 2011-09-13 Pentair Water Pool And Spa, Inc. Control algorithm of variable speed pumping system
US7686589B2 (en) * 2004-08-26 2010-03-30 Pentair Water Pool And Spa, Inc. Pumping system with power optimization
US7854597B2 (en) 2004-08-26 2010-12-21 Pentair Water Pool And Spa, Inc. Pumping system with two way communication
US8480373B2 (en) * 2004-08-26 2013-07-09 Pentair Water Pool And Spa, Inc. Filter loading
US7874808B2 (en) * 2004-08-26 2011-01-25 Pentair Water Pool And Spa, Inc. Variable speed pumping system and method
US8602745B2 (en) * 2004-08-26 2013-12-10 Pentair Water Pool And Spa, Inc. Anti-entrapment and anti-dead head function
US7845913B2 (en) 2004-08-26 2010-12-07 Pentair Water Pool And Spa, Inc. Flow control
WO2006032692A1 (en) * 2004-09-22 2006-03-30 Novo Nordisk A/S Medical device with cannula inserter
CN100584399C (en) * 2004-09-22 2010-01-27 诺和诺德公司 Medical device with transcutaneous cannula device
CN100579598C (en) * 2004-12-06 2010-01-13 诺和诺德公司 Ventilated skin mountable device
DE102004059126B4 (en) * 2004-12-08 2014-01-16 Roche Diagnostics Gmbh Adapter for injection device
CN101107028B (en) * 2005-01-24 2013-04-10 诺和诺德公司 Transcutaneous device assembly
US8903492B2 (en) 2005-02-07 2014-12-02 Medtronic, Inc. Ion imbalance detector
EP1861138A1 (en) * 2005-02-23 2007-12-05 Novo Nordisk A/S Method and apparatus for reversing a piston rod in an injection device
EP1898975A2 (en) * 2005-05-13 2008-03-19 Novo Nordisk A/S Medical device adapted to detect disengagement of a transcutaneous device
US8603034B2 (en) 2005-07-12 2013-12-10 Applied Diabetes Research, Inc. One piece sealing reservoir for an insulin infusion pump
US9144645B2 (en) * 2005-09-21 2015-09-29 Applied Diabetes Research, Inc. One piece sealing reservoir for an insulin infusion pump
EP1940491A4 (en) * 2005-08-22 2016-08-31 Patton Medical Devices Lp Fluid delivery devices, systems and methods
US20070066940A1 (en) * 2005-09-19 2007-03-22 Lifescan, Inc. Systems and Methods for Detecting a Partition Position in an Infusion Pump
US20070066939A1 (en) * 2005-09-19 2007-03-22 Lifescan, Inc. Electrokinetic Infusion Pump System
US20070093752A1 (en) * 2005-09-19 2007-04-26 Lifescan, Inc. Infusion Pumps With A Position Detector
JP4983180B2 (en) * 2005-09-20 2012-07-25 パナソニック株式会社 Puncture function with the injection device, a control method of the puncture function with the injection device, a control method of the chemical solution administration device, and the drug solution administration device
EP1948267A4 (en) 2005-11-03 2012-12-19 Patton Medical Devices Lp Fluid delivery devices, systems and methods
KR100629994B1 (en) * 2005-12-30 2006-09-22 한국뉴매틱(주) Vacuum ejector pumps
US8657788B2 (en) 2006-02-07 2014-02-25 Tecpharma Licensing Ag Infusion set
EP1993634B1 (en) * 2006-02-09 2011-04-06 Deka Products Limited Partnership Patch-sized fluid delivery systems
US9173992B2 (en) * 2006-03-13 2015-11-03 Novo Nordisk A/S Secure pairing of electronic devices using dual means of communication
JP2009529930A (en) * 2006-03-13 2009-08-27 ノボ・ノルデイスク・エー/エス Medical system comprising a dual-purpose communication means
SG173319A1 (en) 2006-03-30 2011-08-29 Valeritas Inc Multi-cartridge fluid delivery device
AT552874T (en) 2006-04-19 2012-04-15 Novo Nordisk As Fluid infusion system, method for assembling this system and drug reservoir for use in the system
JP5297372B2 (en) * 2006-04-19 2013-09-25 ノボ・ノルデイスク・エー/エス Fluid injection system, a drug container used in the assembly method and the system of the system
CN101426542A (en) * 2006-04-26 2009-05-06 诺沃-诺迪斯克有限公司 Skin-mountable device in packaging comprising coated seal member
US20070255126A1 (en) 2006-04-28 2007-11-01 Moberg Sheldon B Data communication in networked fluid infusion systems
KR101092814B1 (en) 2006-05-25 2011-12-12 바이엘 헬스케어 엘엘씨 Reconstitution device
EP2032188A1 (en) * 2006-06-06 2009-03-11 Novo Nordisk A/S Assembly comprising skin-mountable device and packaging therefore
EP2054008B1 (en) 2006-08-18 2012-01-11 Medingo Ltd. Methods and devices for delivering fluid to a reservoir of a fluid delivery device
US8512288B2 (en) * 2006-08-23 2013-08-20 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
EP2061536B1 (en) * 2006-08-23 2011-10-19 Medtronic MiniMed, Inc. Systems and methods allowing for reservoir filling and infusion medium delivery
US7905868B2 (en) * 2006-08-23 2011-03-15 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US8277415B2 (en) * 2006-08-23 2012-10-02 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US9056165B2 (en) 2006-09-06 2015-06-16 Medtronic Minimed, Inc. Intelligent therapy recommendation algorithm and method of using the same
US8202267B2 (en) * 2006-10-10 2012-06-19 Medsolve Technologies, Inc. Method and apparatus for infusing liquid to a body
US7780201B2 (en) * 2006-10-13 2010-08-24 Medela Holding Ag Tube connector with three part construction and latching component
US8221363B2 (en) * 2006-10-18 2012-07-17 Baxter Healthcare S.A. Luer activated device with valve element under tension
US20080097407A1 (en) * 2006-10-18 2008-04-24 Michael Plishka Luer activated device with compressible valve element
US7981090B2 (en) * 2006-10-18 2011-07-19 Baxter International Inc. Luer activated device
KR20130095317A (en) 2006-10-22 2013-08-27 이데브 테크놀로지스, 아이엔씨. Devices and methods for stent advancement
RU2454974C2 (en) 2006-10-22 2012-07-10 Айдев Текнолоджиз, Инк. Devices and methods for stent movement
US7753338B2 (en) 2006-10-23 2010-07-13 Baxter International Inc. Luer activated device with minimal fluid displacement
WO2008062335A1 (en) 2006-11-21 2008-05-29 Koninklijke Philips Electronics, N.V. Medicament delivery device, capsule and in vivo medicine delivery or diagnostic system
US7654127B2 (en) * 2006-12-21 2010-02-02 Lifescan, Inc. Malfunction detection in infusion pumps
US20100196439A1 (en) * 2006-12-22 2010-08-05 Medtronic, Inc. Angiogenesis Mechanism and Method, and Implantable Device
US20080161754A1 (en) * 2006-12-29 2008-07-03 Medsolve Technologies, Inc. Method and apparatus for infusing liquid to a body
US8172799B2 (en) * 2007-01-10 2012-05-08 Acist Medical Systems, Inc. Volumetric pump
WO2008098087A2 (en) 2007-02-06 2008-08-14 Glumetrics, Inc. Optical systems and methods for rationmetric measurement of blood glucose concentration
EP1958660B8 (en) * 2007-02-15 2009-10-07 F.Hoffmann-La Roche Ag Bayonet Luer locking connection for an insulin pump
WO2008107467A1 (en) * 2007-03-06 2008-09-12 Novo Nordisk A/S Pump assembly comprising actuator system
DE102007018696A1 (en) * 2007-04-18 2008-10-23 Sanofi-Aventis Deutschland Gmbh An injection device for dispensing medicament
US8434528B2 (en) 2007-04-30 2013-05-07 Medtronic Minimed, Inc. Systems and methods for reservoir filling
US8323250B2 (en) 2007-04-30 2012-12-04 Medtronic Minimed, Inc. Adhesive patch systems and methods
US8613725B2 (en) 2007-04-30 2013-12-24 Medtronic Minimed, Inc. Reservoir systems and methods
US7963954B2 (en) 2007-04-30 2011-06-21 Medtronic Minimed, Inc. Automated filling systems and methods
JP5102350B2 (en) * 2007-04-30 2012-12-19 メドトロニック ミニメド インコーポレイテッド A method using a reservoir filling / bubble management / infusion medium delivery system and the system
US8597243B2 (en) * 2007-04-30 2013-12-03 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US7959715B2 (en) 2007-04-30 2011-06-14 Medtronic Minimed, Inc. Systems and methods allowing for reservoir air bubble management
US9333293B2 (en) * 2007-05-09 2016-05-10 Acist Medical Systems, Inc. Injector device, method, and computer program product for detecting a vacuum within a syringe
CA2686065A1 (en) 2007-05-10 2008-11-20 Glumetrics, Inc. Equilibrium non-consuming fluorescence sensor for real time intravascular glucose measurement
US8062008B2 (en) * 2007-09-27 2011-11-22 Curlin Medical Inc. Peristaltic pump and removable cassette therefor
US8083503B2 (en) * 2007-09-27 2011-12-27 Curlin Medical Inc. Peristaltic pump assembly and regulator therefor
US7934912B2 (en) * 2007-09-27 2011-05-03 Curlin Medical Inc Peristaltic pump assembly with cassette and mounting pin arrangement
DE102007049446A1 (en) * 2007-10-16 2009-04-23 Cequr Aps Catheter introducer
CA2701772A1 (en) * 2007-10-31 2009-05-07 Novo Nordisk A/S Non-porous material as sterilization barrier
JP5252890B2 (en) 2007-11-16 2013-07-31 キヤノン株式会社 Medicine ejection device
US20090157003A1 (en) * 2007-12-14 2009-06-18 Jones Daniel W Method And Apparatus For Occlusion Prevention And Remediation
US8313467B2 (en) 2007-12-27 2012-11-20 Medtronic Minimed, Inc. Reservoir pressure equalization systems and methods
US9526830B2 (en) 2007-12-31 2016-12-27 Deka Products Limited Partnership Wearable pump assembly
US8708961B2 (en) * 2008-01-28 2014-04-29 Medsolve Technologies, Inc. Apparatus for infusing liquid to a body
US20090188575A1 (en) * 2008-01-28 2009-07-30 Colder Products Company Quick Connect/Disconnect Coupling Assemblies
US8864736B2 (en) * 2008-02-08 2014-10-21 Codan Us Corporation Enteral feeding safety reservoir and system
US8366697B2 (en) * 2008-02-08 2013-02-05 Codan Us Corporation Enteral feeding safety reservoir and system
DK2108393T3 (en) 2008-04-11 2018-03-05 Hoffmann La Roche Delivery device with patient condition monitor
US8206353B2 (en) * 2008-04-11 2012-06-26 Medtronic Minimed, Inc. Reservoir barrier layer systems and methods
US9295776B2 (en) * 2008-04-11 2016-03-29 Medtronic Minimed, Inc. Reservoir plunger head systems and methods
US8858501B2 (en) * 2008-04-11 2014-10-14 Medtronic Minimed, Inc. Reservoir barrier layer systems and methods
US8882700B2 (en) 2008-05-02 2014-11-11 Baxter International Inc. Smart patient transfer set for peritoneal dialysis
EP2276537B1 (en) * 2008-05-14 2018-02-14 Becton, Dickinson and Company Separatable infusion set with cleanable interface and straight line attachment
US8057679B2 (en) 2008-07-09 2011-11-15 Baxter International Inc. Dialysis system having trending and alert generation
US8700114B2 (en) 2008-07-31 2014-04-15 Medtronic Minmed, Inc. Analyte sensor apparatuses comprising multiple implantable sensor elements and methods for making and using them
US7954515B2 (en) * 2008-08-15 2011-06-07 Colder Products Company Combination cap and plug assembly
MX2011003708A (en) 2008-10-06 2011-06-16 Pentair Water Pool & Spa Inc Method of operating a safety vacuum release system.
US8223028B2 (en) 2008-10-10 2012-07-17 Deka Products Limited Partnership Occlusion detection system and method
US8066672B2 (en) 2008-10-10 2011-11-29 Deka Products Limited Partnership Infusion pump assembly with a backup power supply
US9180245B2 (en) 2008-10-10 2015-11-10 Deka Products Limited Partnership System and method for administering an infusible fluid
US8016789B2 (en) 2008-10-10 2011-09-13 Deka Products Limited Partnership Pump assembly with a removable cover assembly
US8267892B2 (en) 2008-10-10 2012-09-18 Deka Products Limited Partnership Multi-language / multi-processor infusion pump assembly
US8708376B2 (en) 2008-10-10 2014-04-29 Deka Products Limited Partnership Medium connector
US8262616B2 (en) 2008-10-10 2012-09-11 Deka Products Limited Partnership Infusion pump assembly
US8554579B2 (en) 2008-10-13 2013-10-08 Fht, Inc. Management, reporting and benchmarking of medication preparation
WO2010076275A1 (en) * 2008-12-29 2010-07-08 Sanofi-Aventis Deutschland Gmbh Medical injection device with electric motor drive control
US20100168711A1 (en) 2008-12-30 2010-07-01 Medtronic Minimed, Inc. Color detection system for detecting reservoir presence and content in device
WO2010088512A1 (en) 2009-01-30 2010-08-05 Baxter International Inc. Transfer sets for therapy optimization
US20100204650A1 (en) * 2009-02-09 2010-08-12 Sigma International General Medical Apparatus LLC Infusion pump and method to prevent titration errors in infusion therapies
US8378837B2 (en) * 2009-02-20 2013-02-19 Hospira, Inc. Occlusion detection system
US20100217233A1 (en) * 2009-02-20 2010-08-26 Ranft Elizabeth A Method and device to anesthetize an area
WO2010107695A1 (en) * 2009-03-16 2010-09-23 Colder Products Company Aseptic coupling devices
EP2229967A1 (en) 2009-03-17 2010-09-22 F.Hoffmann-La Roche Ag Cannula assembly and ambulatory infusion system with a pressure sensor made of stackes coplanar layers
US20110023281A1 (en) * 2009-04-30 2011-02-03 Stat Medical Devices, Inc. Pen injection device cap with integral pen needle quick release and/or removal system
US9556874B2 (en) * 2009-06-09 2017-01-31 Pentair Flow Technologies, Llc Method of controlling a pump and motor
US8564233B2 (en) 2009-06-09 2013-10-22 Sta-Rite Industries, Llc Safety system and method for pump and motor
US8970384B2 (en) 2009-06-14 2015-03-03 Roche Diagnostics Operations, Inc. Devices and methods for malfunctions recognition in a therapeutic dispensing device
AU2010278894B2 (en) 2009-07-30 2014-01-30 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US8547239B2 (en) 2009-08-18 2013-10-01 Cequr Sa Methods for detecting failure states in a medicine delivery device
US8672873B2 (en) 2009-08-18 2014-03-18 Cequr Sa Medicine delivery device having detachable pressure sensing unit
US8241018B2 (en) * 2009-09-10 2012-08-14 Tyco Healthcare Group Lp Compact peristaltic medical pump
US9399091B2 (en) 2009-09-30 2016-07-26 Medtronic, Inc. System and method to regulate ultrafiltration
CH702075A1 (en) * 2009-10-16 2011-04-29 Tecpharma Licensing Ag Occlusion in an administration unit.
KR101773849B1 (en) 2009-10-26 2017-09-01 가부시키가이샤 제이.에무.에스 Connector set for medical container and the first connector thereof
US8070723B2 (en) * 2009-12-31 2011-12-06 Medtronic Minimed, Inc. Activity guard
US9677555B2 (en) 2011-12-21 2017-06-13 Deka Products Limited Partnership System, method, and apparatus for infusing fluid
US9675756B2 (en) 2011-12-21 2017-06-13 Deka Products Limited Partnership Apparatus for infusing fluid
US9381304B2 (en) * 2010-04-23 2016-07-05 Sanofi-Aventis Deutschland Gmbh Cartridge holder and alignment interface
US8246573B2 (en) 2010-04-27 2012-08-21 Medtronic, Inc. Detecting empty medical pump reservoir
US9023095B2 (en) 2010-05-27 2015-05-05 Idev Technologies, Inc. Stent delivery system with pusher assembly
US20120123338A1 (en) 2010-06-16 2012-05-17 Medtronic, Inc. Damping systems for stabilizing medications in drug delivery devices
US9215995B2 (en) 2010-06-23 2015-12-22 Medtronic Minimed, Inc. Sensor systems having multiple probes and electrode arrays
US9675751B2 (en) * 2010-07-31 2017-06-13 Becton, Dickinson And Company Infusion reservoir with push-on connector features and/or attachments therefor
US9216249B2 (en) 2010-09-24 2015-12-22 Perqflo, Llc Infusion pumps
US9498573B2 (en) 2010-09-24 2016-11-22 Perqflo, Llc Infusion pumps
US9320849B2 (en) 2010-09-24 2016-04-26 Perqflo, Llc Infusion pumps
US9211378B2 (en) 2010-10-22 2015-12-15 Cequr Sa Methods and systems for dosing a medicament
US9192719B2 (en) * 2010-11-01 2015-11-24 Medtronic, Inc. Implantable medical pump diagnostics
US8905972B2 (en) 2010-11-20 2014-12-09 Perqflo, Llc Infusion pumps
SG191067A1 (en) 2010-12-08 2013-08-30 Pentair Water Pool & Spa Inc Discharge vacuum relief valve for safety vacuum release system
EP2654852A2 (en) * 2010-12-22 2013-10-30 Sanofi-Aventis Deutschland GmbH Dedicated cartridge
US8690855B2 (en) 2010-12-22 2014-04-08 Medtronic Minimed, Inc. Fluid reservoir seating procedure for a fluid infusion device
US8469942B2 (en) 2010-12-22 2013-06-25 Medtronic Minimed, Inc. Occlusion detection for a fluid infusion device
US8628510B2 (en) 2010-12-22 2014-01-14 Medtronic Minimed, Inc. Monitoring the operating health of a force sensor in a fluid infusion device
US8870829B2 (en) 2011-02-22 2014-10-28 Medtronic Minimed, Inc. Fluid infusion device and related sealing assembly for a needleless fluid reservoir
EP2680807B1 (en) * 2011-03-04 2016-08-10 Duoject Medical Systems Inc. Easy linking transfer system
JP5779915B2 (en) * 2011-03-08 2015-09-16 株式会社リコー Image forming apparatus, and the powder container
US9456755B2 (en) 2011-04-29 2016-10-04 Medtronic, Inc. Method and device to monitor patients with kidney disease
US9848778B2 (en) 2011-04-29 2017-12-26 Medtronic, Inc. Method and device to monitor patients with kidney disease
US9700661B2 (en) 2011-04-29 2017-07-11 Medtronic, Inc. Chronic pH or electrolyte monitoring
US9008744B2 (en) 2011-05-06 2015-04-14 Medtronic Minimed, Inc. Method and apparatus for continuous analyte monitoring
US8795231B2 (en) 2011-05-10 2014-08-05 Medtronic Minimed, Inc. Automated reservoir fill system
US10352941B2 (en) 2011-09-27 2019-07-16 Medtronic Minimed, Inc. Method for functionalizing a porous membrane covering of an optical sensor to facilitate coupling of an antithrom-bogenic agent
CN106943645A (en) 2011-10-14 2017-07-14 安姆根有限公司 Injector and method of assembly
US9989522B2 (en) 2011-11-01 2018-06-05 Medtronic Minimed, Inc. Methods and materials for modulating start-up time and air removal in dry sensors
US8662540B2 (en) 2011-11-02 2014-03-04 Philip C. Whitener Quick tube connector
US8999720B2 (en) 2011-11-17 2015-04-07 Medtronic Minimed, Inc. Aqueous radiation protecting formulations and methods for making and using them
CN103127579B (en) * 2011-11-21 2017-06-16 上海泽生科技开发股份有限公司 Portable injection pump drive system
US10022498B2 (en) 2011-12-16 2018-07-17 Icu Medical, Inc. System for monitoring and delivering medication to a patient and method of using the same to minimize the risks associated with automated therapy
EP2800592B1 (en) 2012-01-04 2019-03-06 Medtronic Inc. Multi-staged filtration system for blood fluid removal
CN104245014B (en) 2012-01-31 2017-05-24 麦迪麦珀医疗项目有限公司 Time-dependent drug delivery device
SG192310A1 (en) 2012-02-02 2013-08-30 Becton Dickinson Holdings Pte Ltd Adaptor for coupling to a medical container
SG192312A1 (en) 2012-02-02 2013-08-30 Becton Dickinson Holdings Pte Ltd Adaptor for coupling to a medical container
US9668939B2 (en) 2012-02-02 2017-06-06 Becton Dickinson Holdings Pte. Ltd. Adaptor for coupling with a medical container
US9463280B2 (en) 2012-03-26 2016-10-11 Medimop Medical Projects Ltd. Motion activated septum puncturing drug delivery device
EP2837403B1 (en) * 2012-04-13 2016-09-14 JMS Co., Ltd. Male connector equipped with lock mechanism
EP2837404A4 (en) * 2012-04-13 2016-07-20 Jms Co Ltd Male connector equipped with lock mechanism
US10089443B2 (en) 2012-05-15 2018-10-02 Baxter International Inc. Home medical device systems and methods for therapy prescription and tracking, servicing and inventory
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
US9493807B2 (en) 2012-05-25 2016-11-15 Medtronic Minimed, Inc. Foldover sensors and methods for making and using them
US9555186B2 (en) 2012-06-05 2017-01-31 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US9861746B2 (en) 2012-06-08 2018-01-09 Medtronic Minimed, Inc. Application of electrochemical impedance spectroscopy in sensor systems, devices, and related methods
US20130338576A1 (en) * 2012-06-15 2013-12-19 Wayne C. Jaeschke, Jr. Portable infusion pump with pressure and temperature compensation
US8454562B1 (en) 2012-07-20 2013-06-04 Asante Solutions, Inc. Infusion pump system and method
EP2692328A1 (en) 2012-08-03 2014-02-05 Becton Dickinson France Dose counting device for coupling with a medical container
US9682188B2 (en) 2012-08-21 2017-06-20 Medtronic Minimed, Inc. Reservoir fluid volume estimator and medical device incorporating same
US9662445B2 (en) 2012-08-30 2017-05-30 Medtronic Minimed, Inc. Regulating entry into a closed-loop operating mode of an insulin infusion system
JP6441076B2 (en) * 2012-09-26 2018-12-19 テルモ株式会社 Syringe pump
EP2712650A1 (en) * 2012-09-27 2014-04-02 F. Hoffmann-La Roche AG Adapter and drug cartridge alignment device
EP2712651A1 (en) * 2012-09-27 2014-04-02 F. Hoffmann-La Roche AG Venting device for use in ambulatory infusion system
WO2014049781A1 (en) * 2012-09-27 2014-04-03 テルモ株式会社 Barrel for pre-filled syringe, puncture device for pre-filled syringe, pre-filled syringe and barrel packaging body for pre-filled syringe
JP6031114B2 (en) * 2012-09-27 2016-11-24 テルモ株式会社 Prefilled syringe outer cylinder for, the piercing device and pre-filled syringe for a pre-filled syringe
US9511186B1 (en) 2012-10-23 2016-12-06 Acist Medical Systems, Inc. Medical injection systems and pumps
US9885360B2 (en) 2012-10-25 2018-02-06 Pentair Flow Technologies, Llc Battery backup sump pump systems and methods
EP2916722A4 (en) 2012-11-07 2016-07-20 Medtronic Minimed Inc Dry insertion and one-point in vivo calibration of an optical analyte sensor
US9265455B2 (en) 2012-11-13 2016-02-23 Medtronic Minimed, Inc. Methods and systems for optimizing sensor function by the application of voltage
EP2735300A1 (en) 2012-11-26 2014-05-28 Becton Dickinson France Adaptor for multidose medical container
US10194840B2 (en) 2012-12-06 2019-02-05 Medtronic Minimed, Inc. Microarray electrodes useful with analyte sensors and methods for making and using them
CN104487113B (en) 2012-12-28 2017-07-14 甘布罗伦迪亚股份公司 Detection apparatus and method for engaging syringe pump
US9707328B2 (en) 2013-01-09 2017-07-18 Medtronic, Inc. Sorbent cartridge to measure solute concentrations
US9526822B2 (en) 2013-02-01 2016-12-27 Medtronic, Inc. Sodium and buffer source cartridges for use in a modular controlled compliant flow path
US9623164B2 (en) 2013-02-01 2017-04-18 Medtronic, Inc. Systems and methods for multifunctional volumetric fluid control
US10010663B2 (en) 2013-02-01 2018-07-03 Medtronic, Inc. Fluid circuit for delivery of renal replacement therapies
US9144640B2 (en) 2013-02-02 2015-09-29 Medtronic, Inc. Sorbent cartridge configurations for improved dialysate regeneration
US9827361B2 (en) 2013-02-02 2017-11-28 Medtronic, Inc. pH buffer measurement system for hemodialysis systems
WO2014122739A1 (en) * 2013-02-06 2014-08-14 テルモ株式会社 Infusion pump
KR20150116860A (en) * 2013-02-07 2015-10-16 에쿠아실드 메디칼 리미티드 Improvements to a closed drug transfer system
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
US10022301B2 (en) 2013-03-15 2018-07-17 Becton Dickinson and Company Ltd. Connection system for medical device components
US9414990B2 (en) 2013-03-15 2016-08-16 Becton Dickinson and Company Ltd. Seal system for cannula
US9889256B2 (en) 2013-05-03 2018-02-13 Medimop Medical Projects Ltd. Sensing a status of an infuser based on sensing motor control and power input
WO2014194089A1 (en) 2013-05-29 2014-12-04 Hospira, Inc. Infusion system which utilizes one or more sensors and additional information to make an air determination regarding the infusion system
US9338819B2 (en) 2013-05-29 2016-05-10 Medtronic Minimed, Inc. Variable data usage personal medical system and method
US9457141B2 (en) 2013-06-03 2016-10-04 Bigfoot Biomedical, Inc. Infusion pump system and method
US10194864B2 (en) 2013-06-21 2019-02-05 Medtronic Minimed, Inc. Anchoring apparatus and method for attaching device on body
EP3024532B1 (en) 2013-07-23 2019-01-02 Colder Products Company Aseptic coupling devices
ITTO20130661A1 (en) * 2013-08-02 2015-02-03 Cane S P A Portable pump for l¿infusione of liquid substances into the body of a living being and reservoir for l¿uso in said pump
JP1526207S (en) 2013-08-05 2015-06-15
US8979808B1 (en) 2013-10-14 2015-03-17 Medtronic Minimed, Inc. On-body injector and method of use
US9375537B2 (en) 2013-10-14 2016-06-28 Medtronic Minimed, Inc. Therapeutic agent injection device
US8979799B1 (en) 2013-10-14 2015-03-17 Medtronic Minimed, Inc. Electronic injector
US9265881B2 (en) 2013-10-14 2016-02-23 Medtronic Minimed, Inc. Therapeutic agent injection device
EP3102107A4 (en) 2013-11-04 2018-02-07 Medtronic, Inc. Method and device to manage fluid volumes in the body
US9226709B2 (en) 2013-11-04 2016-01-05 Medtronic Minimed, Inc. ICE message system and method
EP3065811A1 (en) 2013-11-06 2016-09-14 Becton, Dickinson and Company Ltd. System for closed transfer of fluids with a locking member
US9642775B2 (en) 2013-11-06 2017-05-09 Becton Dickinson and Company Limited System for closed transfer of fluids having connector
JP6397014B2 (en) 2013-11-06 2018-09-26 ベクトン ディキンソン アンド カンパニー リミテッド Coupling device for a medical device
EP3065810A1 (en) 2013-11-06 2016-09-14 Becton, Dickinson and Company Ltd. Medical connector having locking engagement
US9267875B2 (en) 2013-11-21 2016-02-23 Medtronic Minimed, Inc. Accelerated life testing device and method
US20150164382A1 (en) 2013-12-16 2015-06-18 Medtronic Minimed, Inc. Use of electrochemical impedance spectroscopy (eis) in continuous glucose monitoring
US20150164385A1 (en) 2013-12-16 2015-06-18 Medtronic Minimed, Inc. Methods and systems for improving the reliability of orthogonally redundant sensors
US9143941B2 (en) 2013-12-18 2015-09-22 Medtronic Minimed, Inc. Secure communication by user selectable communication range
US9779226B2 (en) 2013-12-18 2017-10-03 Medtronic Minimed, Inc. Fingerprint enhanced authentication for medical devices in wireless networks
US10279105B2 (en) 2013-12-26 2019-05-07 Tandem Diabetes Care, Inc. System and method for modifying medicament delivery parameters after a site change
CN103768679B (en) 2014-02-20 2016-08-24 江苏多维科技有限公司 Precision syringe pump and its manufacturing method
WO2015131108A2 (en) 2014-02-28 2015-09-03 Hospira, Inc. Infusion system and method which utilizes dual wavelength optical air-in-line detection
US9388805B2 (en) 2014-03-24 2016-07-12 Medtronic Minimed, Inc. Medication pump test device and method of use
US9689830B2 (en) 2014-04-03 2017-06-27 Medtronic Minimed, Inc. Sensor detection pads with integrated fuse
US9707336B2 (en) 2014-04-07 2017-07-18 Medtronic Minimed, Inc. Priming detection system and method of using the same
EP3132820A4 (en) * 2014-04-14 2017-12-13 Multidimension Technology Co., Ltd. Micro guiding screw pump using magnetic resistance sensor and manufacturing method therefor
CN106232082B (en) 2014-04-16 2019-03-12 贝克顿迪金森有限公司 Fluid delivery system with the part that can axially and rotatably move
EP3134058A1 (en) 2014-04-21 2017-03-01 Becton Dickinson and Company Limited Fluid transfer device and packaging therefor
CN106659635A (en) 2014-04-21 2017-05-10 贝克顿迪金森有限公司 Vial stabilizer base with connectable vial adapter
CN106413661A (en) 2014-04-21 2017-02-15 贝克顿迪金森有限公司 Fluid transfer device and packaging therefor
ES2688366T3 (en) 2014-04-21 2018-11-02 Becton Dickinson and Company Limited Adapter system for closed fluid transfer
CA2946559C (en) 2014-04-21 2018-03-27 Becton Dickinson and Company Limited Syringe adapter with compound motion disengagement
WO2015177652A1 (en) 2014-05-20 2015-11-26 Cequr Sa Medicine delivery device with restricted access filling port
US9901305B2 (en) 2014-06-13 2018-02-27 Medtronic Minimed, Inc. Physiological sensor history backfill system and method
US9452255B2 (en) 2014-07-21 2016-09-27 Medtronic Minimed, Inc. Smart connection interface
EP3174580A4 (en) 2014-07-31 2018-04-04 Hospira, Inc. Injection system
US10137246B2 (en) 2014-08-06 2018-11-27 Bigfoot Biomedical, Inc. Infusion pump assembly and method
US9717845B2 (en) 2014-08-19 2017-08-01 Medtronic Minimed, Inc. Geofencing for medical devices
US9919096B2 (en) 2014-08-26 2018-03-20 Bigfoot Biomedical, Inc. Infusion pump system and method
EP3185931A1 (en) 2014-08-26 2017-07-05 Debiotech S.A. Detection of an infusion anomaly
USD792584S1 (en) 2014-09-08 2017-07-18 Neomed, Inc. Male enteral coupling
USD781417S1 (en) 2014-09-08 2017-03-14 Neomed, Inc. Male enteral coupling
AU2015318119B2 (en) 2014-09-18 2019-07-11 Deka Products Limited Partnership Apparatus and method for infusing fluid through a tube by appropriately heating the tube
US9839753B2 (en) 2014-09-26 2017-12-12 Medtronic Minimed, Inc. Systems for managing reservoir chamber pressure
US20160271322A1 (en) * 2014-10-13 2016-09-22 Kirk D. RAMEY Connector for medication delivery system
US9841014B2 (en) 2014-10-20 2017-12-12 Medtronic Minimed, Inc. Insulin pump data acquisition device and system
US9592335B2 (en) 2014-10-20 2017-03-14 Medtronic Minimed, Inc. Insulin pump data acquisition device
NO2689315T3 (en) 2014-10-28 2018-04-14
US9199033B1 (en) 2014-10-28 2015-12-01 Bayer Healthcare Llc Self-orienting syringe and syringe interface
US9731067B2 (en) 2014-11-25 2017-08-15 Medtronic Minimed, Inc. Mechanical injection pump and method of use
US9833564B2 (en) * 2014-11-25 2017-12-05 Medtronic Minimed, Inc. Fluid conduit assembly with air venting features
US9901675B2 (en) 2014-11-25 2018-02-27 Medtronic Minimed, Inc. Infusion set insertion device and method of use
US10195341B2 (en) * 2014-11-26 2019-02-05 Medtronic Minimed, Inc. Systems and methods for fluid infusion device with automatic reservoir fill
US9987420B2 (en) * 2014-11-26 2018-06-05 Medtronic Minimed, Inc. Systems and methods for fluid infusion device with automatic reservoir fill
US9713665B2 (en) 2014-12-10 2017-07-25 Medtronic, Inc. Degassing system for dialysis
US9895479B2 (en) 2014-12-10 2018-02-20 Medtronic, Inc. Water management system for use in dialysis
US10098993B2 (en) 2014-12-10 2018-10-16 Medtronic, Inc. Sensing and storage system for fluid balance
US9987416B2 (en) * 2015-01-09 2018-06-05 BioQuiddity Inc. Sterile assembled liquid medicament dosage control and delivery device
US9717848B2 (en) 2015-01-22 2017-08-01 Medtronic Minimed, Inc. Data derived pre-bolus delivery
US9872954B2 (en) 2015-03-02 2018-01-23 Medtronic Minimed, Inc. Belt clip
US9795534B2 (en) 2015-03-04 2017-10-24 Medimop Medical Projects Ltd. Compliant coupling assembly for cartridge coupling of a drug delivery device
US10251813B2 (en) 2015-03-04 2019-04-09 West Pharma. Services IL, Ltd. Flexibly mounted cartridge alignment collar for drug delivery device
US20170312181A1 (en) 2015-03-24 2017-11-02 Neomed, Inc. Oral administration coupler for back-of-mouth delivery
US9744297B2 (en) 2015-04-10 2017-08-29 Medimop Medical Projects Ltd. Needle cannula position as an input to operational control of an injection device
US10130757B2 (en) 2015-05-01 2018-11-20 Medtronic Minimed, Inc. Method and system for leakage detection in portable medical devices
EP3319662A4 (en) * 2015-07-08 2019-03-13 Trustees of Boston University Infusion system and components thereof
WO2017031407A1 (en) 2015-08-20 2017-02-23 Tandem Diabetes Care, Inc. Drive mechanism for infusion pump
US10086145B2 (en) 2015-09-22 2018-10-02 West Pharma Services Il, Ltd. Rotation resistant friction adapter for plunger driver of drug delivery device
US9992818B2 (en) 2015-10-06 2018-06-05 Medtronic Minimed, Inc. Protocol translation device
US9757511B2 (en) 2015-10-19 2017-09-12 Medtronic Minimed, Inc. Personal medical device and method of use with restricted mode challenge
AU2016344178A1 (en) * 2015-10-28 2018-04-19 Bayer Healthcare Llc System and method for fluid injector engagement with a pressure jacket and syringe cap
US9848805B2 (en) 2015-12-18 2017-12-26 Medtronic Minimed, Inc. Biostable glucose permeable polymer
US10327680B2 (en) 2015-12-28 2019-06-25 Medtronic Minimed, Inc. Sensor systems, devices, and methods for continuous glucose monitoring
US10349872B2 (en) 2015-12-28 2019-07-16 Medtronic Minimed, Inc. Methods, systems, and devices for sensor fusion
US10327686B2 (en) 2015-12-28 2019-06-25 Medtronic Minimed, Inc. Sensor systems, devices, and methods for continuous glucose monitoring
JP6240239B2 (en) * 2016-03-03 2017-11-29 テルモ株式会社 Portable infusion pump
US10324058B2 (en) 2016-04-28 2019-06-18 Medtronic Minimed, Inc. In-situ chemistry stack for continuous glucose sensors
US9970893B2 (en) 2016-04-28 2018-05-15 Medtronic Minimed, Inc. Methods, systems, and devices for electrode capacitance calculation and application
US10086133B2 (en) 2016-05-26 2018-10-02 Medtronic Minimed, Inc. Systems for set connector assembly with lock
US10086134B2 (en) 2016-05-26 2018-10-02 Medtronic Minimed, Inc. Systems for set connector assembly with lock
US9968737B2 (en) 2016-05-26 2018-05-15 Medtronic Minimed, Inc. Systems for set connector assembly with lock
WO2018026970A1 (en) * 2016-08-02 2018-02-08 Qorvo Us, Inc. Biosensor cartridge with sample acquisition
CN109789266A (en) * 2016-09-29 2019-05-21 皇家飞利浦有限公司 System and method for predicting motor fret in transfusion system
USD836774S1 (en) * 2016-12-16 2018-12-25 Sorrento Therapeutics, Inc. Cartridge for a fluid delivery apparatus

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3701345A (en) * 1970-09-29 1972-10-31 Medrad Inc Angiographic injector equipment
DE2240694A1 (en) * 1971-08-20 1973-03-01 Rene Derouineau Syringe for intravenous injection or intramuskulaere
US4562751A (en) 1984-01-06 1986-01-07 Nason Clyde K Solenoid drive apparatus for an external infusion pump
US4619646A (en) * 1984-01-25 1986-10-28 Fernandez Tresguerres Hernande Device for the delivery-dosing of injectable products
US4678408A (en) 1984-01-06 1987-07-07 Pacesetter Infusion, Ltd. Solenoid drive apparatus for an external infusion pump
US4685903A (en) 1984-01-06 1987-08-11 Pacesetter Infusion, Ltd. External infusion pump apparatus
US4747824A (en) * 1986-05-30 1988-05-31 Spinello Ronald P Hypodermic anesthetic injection method
US5080653A (en) 1990-04-16 1992-01-14 Pacesetter Infusion, Ltd. Infusion pump with dual position syringe locator
US5097122A (en) 1990-04-16 1992-03-17 Pacesetter Infusion, Ltd. Medication infusion system having optical motion sensor to detect drive mechanism malfunction
US5219099A (en) * 1991-09-06 1993-06-15 California Institute Of Technology Coaxial lead screw drive syringe pump

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US462751A (en) 1891-11-10 Electric-railway motor
US3623474A (en) 1966-07-25 1971-11-30 Medrad Inc Angiographic injection equipment
US4076285A (en) * 1975-08-01 1978-02-28 Erika, Inc. Laminar flow connector for conduits
US4084588A (en) 1976-03-19 1978-04-18 Sherwood Medical Industries Inc. Parenteral drug storage device with closure piercing coupling member
US4267836A (en) * 1976-11-12 1981-05-19 Whitney Douglass G Injection device and method
US4351335A (en) * 1979-04-16 1982-09-28 Whitney Douglass G Injection device and method
US4278188A (en) * 1979-10-01 1981-07-14 George M. Stephenson Remote delivery nozzle assembly for pressurized container
US4274407A (en) * 1979-11-13 1981-06-23 Med Pump, Inc. Fluid injection system
US4444546A (en) 1980-09-19 1984-04-24 Oximetrix, Inc. Occlusion detection apparatus and method
US4468221A (en) 1981-04-10 1984-08-28 Parker-Hannifin Corporation Medication infusion pump
US5330450A (en) * 1983-01-24 1994-07-19 Icu Medical, Inc. Medical connector
US4752292A (en) * 1983-01-24 1988-06-21 Icu Medical, Inc. Medical connector
NL8300386A (en) * 1983-02-02 1984-09-03 Steritech Bv Apparatus for the sterile connection with each other in sets of two chambers.
EP0126718A3 (en) * 1983-05-20 1985-10-23 Bengt Gustavsson A device for transferring a substance from one vessel to another and further to the intended application
DE3468173D1 (en) 1983-09-07 1988-02-04 Disetronic Ag Portable infusion apparatus
US4601491A (en) 1983-10-19 1986-07-22 Vetco Offshore, Inc. Pipe connector
US4749109A (en) 1983-11-15 1988-06-07 Kamen Dean L Volumetric pump with replaceable reservoir assembly
IT1173370B (en) * 1984-02-24 1987-06-24 Erba Farmitalia Safety device for connecting a syringe to the mouth of a bottle containing a drug or a tube for dispensing the drug of the syringe
US4588403A (en) 1984-06-01 1986-05-13 American Hospital Supply Corporation Vented syringe adapter assembly
US4744790A (en) 1986-08-19 1988-05-17 The West Company Fast action cartridge syringe holder
DE8702656U1 (en) 1986-08-28 1987-10-08 Pradler, Josef, 7312 Kirchheim, De
EP0285679A1 (en) 1987-04-04 1988-10-12 B. Braun-SSC AG Pressure infusion apparatus
GB8713810D0 (en) * 1987-06-12 1987-07-15 Hypoguard Uk Ltd Measured dose dispensing device
US4834744A (en) * 1987-11-04 1989-05-30 Critikon, Inc. Spike for parenteral solution container
US4919596A (en) * 1987-12-04 1990-04-24 Pacesetter Infusion, Ltd. Fluid delivery control and monitoring apparatus for a medication infusion system
US5100394A (en) * 1988-01-25 1992-03-31 Baxter International Inc. Pre-slit injection site
DE68916876D1 (en) * 1988-01-25 1994-08-25 Baxter Int Pre-slit injection device and conical cannula.
FR2628639B1 (en) * 1988-03-21 1994-03-04 Microtechnic An implantable device for medical liquid infusion
IT1217595B (en) * 1988-05-13 1990-03-30 Molteni & C anticontagio device for injecting dental anesthetic solutions contained in cartridges
US5246347A (en) * 1988-05-17 1993-09-21 Patients Solutions, Inc. Infusion device with disposable elements
JP2909906B2 (en) 1988-05-30 1999-06-23 ミノルタ株式会社 Water and waterproofing products of the internal pressure adjustment mechanism
US5087250A (en) * 1988-07-26 1992-02-11 Gish Biomedical, Inc. Autotransfusion unit with vacuum regulation and cardiotomy reservoir
DE3833821A1 (en) * 1988-10-05 1990-04-12 Braun Melsungen Ag injection device
CA2001732A1 (en) * 1988-10-31 1990-04-30 Lawrence A. Lynn Intravenous line coupling device
US4962533A (en) * 1989-02-17 1990-10-09 Texas Instrument Incorporated Data protection for computer systems
US5279556A (en) * 1989-04-28 1994-01-18 Sharp Kabushiki Kaisha Peristaltic pump with rotary encoder
US5374256A (en) * 1989-06-16 1994-12-20 Science Incorporated Fluid container for use with a fluid delivery apparatus
DE9013145U1 (en) 1989-09-22 1990-11-22 B. Braun Melsungen Ag, 3508 Melsungen, De
US5514090A (en) * 1990-04-24 1996-05-07 Science Incorporated Closed drug delivery system
ES2094814T3 (en) * 1990-05-07 1997-02-01 Winfield Ind Inc Connector for medical tube intravenous administration.
DK228290D0 (en) 1990-09-21 1990-09-21 Novo Nordisk As An injection unit
US5254306A (en) * 1990-10-29 1993-10-19 Toyoda Gosei Co., Ltd. Method for making a double layer molded product using a dam in the mold cavity
US5201717A (en) * 1990-12-05 1993-04-13 Philip Wyatt Safety enclosure
JPH0613744Y2 (en) 1991-01-18 1994-04-13 テルモ株式会社 Puncture needle
US5300031A (en) * 1991-06-07 1994-04-05 Liebel-Flarsheim Company Apparatus for injecting fluid into animals and disposable front loadable syringe therefor
DK134691D0 (en) 1991-07-12 1991-07-12 Novo Nordisk As Apparatus
JP2870257B2 (en) 1991-09-12 1999-03-17 日立電線株式会社 Method of manufacturing the electrical contact
US5188610A (en) * 1991-10-18 1993-02-23 Vetrisystems, Inc. Fluid dispensing apparatus
US5700244A (en) * 1992-04-17 1997-12-23 Science Incorporated Fluid dispenser with fill adapter
US5251873B1 (en) * 1992-06-04 1995-05-02 Vernay Laboratories Medical coupling site.
US5261572A (en) * 1992-06-09 1993-11-16 Plato Products, Inc. Dropper bottle
US5254096A (en) 1992-09-23 1993-10-19 Becton, Dickinson And Company Syringe pump with graphical display or error conditions
US5334179A (en) * 1992-10-16 1994-08-02 Abbott Laboratories Latching piercing pin for use with fluid vials of varying sizes
US5292306A (en) 1993-01-29 1994-03-08 Abbott Laboratories Method of detecting occlusions in a solution pumping system
DE69420240D1 (en) * 1993-06-30 1999-09-30 Baxter Int bottle adapter
JP3199524B2 (en) * 1993-08-06 2001-08-20 日本メジフィジックス株式会社 Luer needle unit and the syringe
US5389078A (en) 1993-10-06 1995-02-14 Sims Deltec, Inc. Programmable infusion pump for administering medication to patients
DE4342251C1 (en) 1993-12-10 1995-05-11 Dental Kosmetik Gmbh Dresden Turning off closure for containers
JP3320179B2 (en) * 1993-12-17 2002-09-03 シャープ株式会社 Infusion pump
US5527307A (en) * 1994-04-01 1996-06-18 Minimed Inc. Implantable medication infusion pump with discharge side port
FR2718645B1 (en) * 1994-04-15 1996-07-12 Nycomed Lab Sa The dilatation catheter in rapid exchange.
US6115819A (en) * 1994-05-26 2000-09-05 The Commonwealth Of Australia Secure computer architecture
US5881287A (en) * 1994-08-12 1999-03-09 Mast; Michael B. Method and apparatus for copy protection of images in a computer system
US5549574A (en) 1994-08-30 1996-08-27 Eli Lilly And Company Cartridge assembly for use in a pen-type medicament injector
US5505709A (en) 1994-09-15 1996-04-09 Minimed, Inc., A Delaware Corporation Mated infusion pump and syringe
US5545152A (en) 1994-10-28 1996-08-13 Minimed Inc. Quick-connect coupling for a medication infusion system
US5637095A (en) 1995-01-13 1997-06-10 Minimed Inc. Medication infusion pump with flexible drive plunger
AT244584T (en) 1995-01-16 2003-07-15 Baxter Int Self-supporting sheet-cross-linked fibrin to inhibition of postoperative adhesions
US5647845A (en) * 1995-02-01 1997-07-15 Habley Medical Technology Corporation Generic intravenous infusion system
US5647853A (en) 1995-03-03 1997-07-15 Minimed Inc. Rapid response occlusion detector for a medication infusion pump
EP0814861B1 (en) * 1995-03-14 2002-06-05 Siemens Aktiengesellschaft Ultrasonic atomizer device with removable precision dosing unit
US5779675A (en) 1995-08-25 1998-07-14 Medrad, Inc. Front load pressure jacket system with syringe holder
US5810792A (en) * 1996-04-03 1998-09-22 Icu Medical, Inc. Locking blunt cannula
US5897526A (en) * 1996-06-26 1999-04-27 Vaillancourt; Vincent L. Closed system medication administering system
US5916582A (en) 1996-07-03 1999-06-29 Alza Corporation Aqueous formulations of peptides
US5825879A (en) * 1996-09-30 1998-10-20 Intel Corporation System and method for copy-protecting distributed video content
US5895383A (en) * 1996-11-08 1999-04-20 Bracco Diagnostics Inc. Medicament container closure with recessed integral spike access means
US5817082A (en) * 1996-11-08 1998-10-06 Bracco Diagnostics Inc. Medicament container closure with integral spike access means
US5947935A (en) 1996-11-12 1999-09-07 Medrad, Inc. Syringes, syringe plungers and injector systems
DE19717107B4 (en) 1997-04-23 2005-06-23 Disetronic Licensing Ag System of container and driving apparatus for a piston which is held in the fluid containing a drug container
EP1019121A4 (en) 1997-08-22 2001-04-04 Coeur Lab Inc Angiographic injection syringe and front-load injector adapter
DE19746595C2 (en) * 1997-10-22 2001-07-12 Bosch Gmbh Robert Drive unit with an electric motor
US6090082A (en) * 1998-02-23 2000-07-18 Becton, Dickinson And Company Vial retainer interface to a medication delivery pen
US5993425A (en) * 1998-04-15 1999-11-30 Science Incorporated Fluid dispenser with reservoir fill assembly
US6475183B1 (en) * 1998-06-03 2002-11-05 Baxter International Inc. Direct dual filling device for sealing agents
US5993423A (en) * 1998-08-18 1999-11-30 Choi; Soo Bong Portable automatic syringe device and injection needle unit thereof
DK1166808T3 (en) 1998-08-20 2004-07-05 Sooil Dev Co Ltd Portable automatic spröjteenhed thereof and the injection needle assembly
US20020173748A1 (en) * 1998-10-29 2002-11-21 Mcconnell Susan Reservoir connector
US6817990B2 (en) * 1998-10-29 2004-11-16 Medtronic Minimed, Inc. Fluid reservoir piston
AT289523T (en) * 1998-10-29 2005-03-15 Medtronic Minimed Inc Compact pump drive system
US6260890B1 (en) * 1999-08-12 2001-07-17 Breg, Inc. Tubing connector
AU2002306833A1 (en) 2001-03-23 2002-10-08 Sterling Medivations, Inc. Adapter for medication cartridges

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3701345A (en) * 1970-09-29 1972-10-31 Medrad Inc Angiographic injector equipment
DE2240694A1 (en) * 1971-08-20 1973-03-01 Rene Derouineau Syringe for intravenous injection or intramuskulaere
US4562751A (en) 1984-01-06 1986-01-07 Nason Clyde K Solenoid drive apparatus for an external infusion pump
US4678408A (en) 1984-01-06 1987-07-07 Pacesetter Infusion, Ltd. Solenoid drive apparatus for an external infusion pump
US4685903A (en) 1984-01-06 1987-08-11 Pacesetter Infusion, Ltd. External infusion pump apparatus
US4619646A (en) * 1984-01-25 1986-10-28 Fernandez Tresguerres Hernande Device for the delivery-dosing of injectable products
US4747824A (en) * 1986-05-30 1988-05-31 Spinello Ronald P Hypodermic anesthetic injection method
US5080653A (en) 1990-04-16 1992-01-14 Pacesetter Infusion, Ltd. Infusion pump with dual position syringe locator
US5097122A (en) 1990-04-16 1992-03-17 Pacesetter Infusion, Ltd. Medication infusion system having optical motion sensor to detect drive mechanism malfunction
US5219099A (en) * 1991-09-06 1993-06-15 California Institute Of Technology Coaxial lead screw drive syringe pump

Cited By (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002051472A1 (en) * 2000-12-22 2002-07-04 Dca Design International Limited Drive mechanism for an injection device
US8926553B2 (en) 2000-12-22 2015-01-06 Christopher Nigel Langley Pen-type injector having an electronic control unit
US7699815B2 (en) 2000-12-22 2010-04-20 Dca Design International Limited Drive mechanism for an injection device
EP1219312A3 (en) * 2000-12-29 2003-01-02 CANE' S.r.l. Portable apparatus for infusing drugs
EP1409063A1 (en) * 2001-07-03 2004-04-21 Syntheon, LLC. Methods and apparatus for sclerosing the wall of a varicose vein
EP1409063A4 (en) * 2001-07-03 2007-11-07 Syntheon Llc Methods and apparatus for sclerosing the wall of a varicose vein
EP1641516A2 (en) * 2003-06-09 2006-04-05 Nipro Diabetes Systems, Inc. Coupling system for an infusion pump
EP1641516A4 (en) * 2003-06-09 2010-03-03 Nipro Diabetes Systems Inc Coupling system for an infusion pump
FR2856929A1 (en) * 2003-07-03 2005-01-07 Olivetti S N C Di Olivetti E F Syringe for injecting a predetermined volume of liquid, useful in veterinary medicine and for injection of cadavers, includes an electromechanical device for controlling advance of the piston
WO2008106806A1 (en) * 2007-03-02 2008-09-12 Tecpharma Licensing Ag Modular administration system
US8679070B2 (en) 2007-03-02 2014-03-25 Tecpharma Licensing Ag Modular administration system
US9345836B2 (en) 2007-10-02 2016-05-24 Medimop Medical Projects Ltd. Disengagement resistant telescoping assembly and unidirectional method of assembly for such
US9861759B2 (en) 2007-10-02 2018-01-09 Medimop Medical Projects Ltd. External drug pump
US9782545B2 (en) 2007-10-02 2017-10-10 Medimop Medical Projects Ltd. External drug pump
US9656019B2 (en) 2007-10-02 2017-05-23 Medimop Medical Projects Ltd. Apparatuses for securing components of a drug delivery system during transport and methods of using same
US9173997B2 (en) 2007-10-02 2015-11-03 Medimop Medical Projects Ltd. External drug pump
US8715268B2 (en) 2008-02-21 2014-05-06 Roche Diagnostics International Ag Administration device having a bolus administration profile controller
US8460244B2 (en) 2008-12-30 2013-06-11 Medtronic Minimed, Inc. Reservoir compartment adapter for infusion device
WO2010078073A1 (en) * 2008-12-30 2010-07-08 Medtronic Minimed, Inc. Reservoir compartment adapter for infusion device
WO2010102750A1 (en) * 2009-03-12 2010-09-16 Imp Pape Gmbh & Co. Kg Method and device for continuously driving a syringe plunger
US9572926B2 (en) 2009-09-15 2017-02-21 Medimop Medical Projects Ltd. Cartridge insertion assembly
US9764092B2 (en) 2010-01-19 2017-09-19 Medimop Medical Projects Ltd. Needle assembly for drug pump
US9149575B2 (en) 2010-01-19 2015-10-06 Medimop Medical Projects Ltd. Needle assembly for drug pump
US9492610B2 (en) 2010-01-19 2016-11-15 MEDIMOP Projects Ltd. Needle assembly for drug pump
US9522234B2 (en) 2010-01-19 2016-12-20 Medimop Medical Projects Ltd. Needle assembly for drug pump
US8915882B2 (en) 2010-01-19 2014-12-23 Medimop Medical Projects Ltd. Needle assembly for drug pump
US9259532B2 (en) 2010-01-19 2016-02-16 Medimop Medical Projects Ltd. Cartridge interface assembly
US9205203B2 (en) 2010-03-31 2015-12-08 Roche Diagnostics International Ag Liquid drug degassing device and ambulatory infusion system including a degassing device
WO2011120660A1 (en) 2010-03-31 2011-10-06 Roche Diagnostics Gmbh Assembly station with component backtracking features
WO2011120661A1 (en) 2010-03-31 2011-10-06 Roche Diagnostics Gmbh Liquid drug degassing device and ambulatory infusion system including a degassing device
EP2372590A1 (en) 2010-03-31 2011-10-05 F.Hoffmann-La Roche Ag Assembly station with component backtracking features
EP2371408A2 (en) 2010-03-31 2011-10-05 Roche Diagnostics GmbH Liquid drug degasing devise and ambulatory infusion system including a degasing device
US9366241B2 (en) 2010-04-15 2016-06-14 Mmi Ag Plunger pump for volumes below one microliter, allowing manual intervention
EP2378119A1 (en) * 2010-04-15 2011-10-19 Mmi Ag Plunger pump with manual insertion possibility for volumes under a microlitre
WO2011141253A1 (en) * 2010-04-15 2011-11-17 Mmi Ag Plunger pump for volumes below one microliter, allowing manual intervention
US9452261B2 (en) 2010-05-10 2016-09-27 Medimop Medical Projects Ltd. Low volume accurate injector
WO2012019726A1 (en) 2010-08-07 2012-02-16 Roche Diagnostics Gmbh Valve for an ambulatory infusion system and ambulatory infusion system including a valve
US10272196B2 (en) 2010-09-24 2019-04-30 Perqflo, Llc Infusion pumps
EP2469432A1 (en) 2010-12-24 2012-06-27 F.Hoffmann-La Roche Ag Ambulatory infusion system with alert prioritizing features
WO2012084128A1 (en) 2010-12-24 2012-06-28 Roche Diagnostics Gmbh Ambulatory infusion system with alert prioritizing features
USD747799S1 (en) 2011-03-22 2016-01-19 Medimop Medical Projects Ltd. Cartridge
USD702834S1 (en) 2011-03-22 2014-04-15 Medimop Medical Projects Ltd. Cartridge for use in injection device
WO2013010561A1 (en) 2011-07-20 2013-01-24 Roche Diagnostics Gmbh Drive control for an ambulatory infusion device
US9072827B2 (en) 2012-03-26 2015-07-07 Medimop Medical Projects Ltd. Fail safe point protector for needle safety flap
US9511190B2 (en) 2012-03-26 2016-12-06 Medimop Medical Projects Ltd. Fail safe point protector for needle safety flap
US9393365B2 (en) 2012-03-26 2016-07-19 Medimop Medical Projects Ltd. Fail safe point protector for needle safety flap
US10071196B2 (en) 2012-05-15 2018-09-11 West Pharma. Services IL, Ltd. Method for selectively powering a battery-operated drug-delivery device and device therefor
US10071198B2 (en) 2012-11-02 2018-09-11 West Pharma. Servicees IL, Ltd. Adhesive structure for medical device
US9421323B2 (en) 2013-01-03 2016-08-23 Medimop Medical Projects Ltd. Door and doorstop for portable one use drug delivery apparatus
US9166313B2 (en) 2013-04-30 2015-10-20 Medimop Medical Projects Power supply contact for installation of printed circuit board
US9011164B2 (en) 2013-04-30 2015-04-21 Medimop Medical Projects Ltd. Clip contact for easy installation of printed circuit board PCB
EP2862586A1 (en) 2013-10-21 2015-04-22 F. Hoffmann-La Roche AG Control unit for infusion pump units, including a controlled intervention unit
US10080840B2 (en) 2013-10-21 2018-09-25 Roche Diabetes Care, Inc. Control unit for infusion pump units, including a controlled intervention unit
EP2865325A1 (en) 2013-10-23 2015-04-29 F. Hoffmann-La Roche AG Skin-adherable cradle for infusion pump or continuous blood glucose monitor having optical indication means
CN105899246A (en) * 2014-01-13 2016-08-24 诺和诺德股份有限公司 Transmission arrangement for motorized drug delivery devic
US10159786B2 (en) 2014-09-30 2018-12-25 Perqflo, Llc Hybrid ambulatory infusion pumps
US10293120B2 (en) 2015-04-10 2019-05-21 West Pharma. Services IL, Ltd. Redundant injection device status indication
US10149943B2 (en) 2015-05-29 2018-12-11 West Pharma. Services IL, Ltd. Linear rotation stabilizer for a telescoping syringe stopper driverdriving assembly
US9987432B2 (en) 2015-09-22 2018-06-05 West Pharma. Services IL, Ltd. Rotation resistant friction adapter for plunger driver of drug delivery device

Also Published As

Publication number Publication date
US8257345B2 (en) 2012-09-04
CA2345439C (en) 2005-08-09
EP1124600A1 (en) 2001-08-22
CA2669175A1 (en) 2000-05-11
JP3546015B2 (en) 2004-07-21
DE69923858T2 (en) 2006-01-12
US7998131B2 (en) 2011-08-16
JP4759630B2 (en) 2011-08-31
US6555986B2 (en) 2003-04-29
DE69928827T2 (en) 2006-08-31
EP1716884A1 (en) 2006-11-02
US6585695B1 (en) 2003-07-01
EP2204203A3 (en) 2016-07-13
CA2345439A1 (en) 2000-05-11
US8500716B2 (en) 2013-08-06
US7658734B2 (en) 2010-02-09
AT289523T (en) 2005-03-15
DK1124608T3 (en) 2006-04-03
US20100082010A1 (en) 2010-04-01
US20100125247A1 (en) 2010-05-20
US20030125672A1 (en) 2003-07-03
US20050021000A1 (en) 2005-01-27
JP2006320757A (en) 2006-11-30
AT498422T (en) 2011-03-15
JP2002528234A (en) 2002-09-03
US20100049135A1 (en) 2010-02-25
WO2000025852A1 (en) 2000-05-11
JP2009233388A (en) 2009-10-15
EP1124608A1 (en) 2001-08-22
DE69943207D1 (en) 2011-03-31
JP4489063B2 (en) 2010-06-23
EP1642615A2 (en) 2006-04-05
US6362591B1 (en) 2002-03-26
CA2533850A1 (en) 2000-05-11
DE69923858D1 (en) 2005-03-31
US7628782B2 (en) 2009-12-08
EP1124600B1 (en) 2005-02-23
CA2346525A1 (en) 2000-05-11
US20130018357A1 (en) 2013-01-17
CA2669175C (en) 2014-01-28
EP2223713A3 (en) 2015-02-18
CA2832936C (en) 2015-08-11
US7988683B2 (en) 2011-08-02
US20130310807A1 (en) 2013-11-21
EP1716884B1 (en) 2013-12-11
US20040003493A1 (en) 2004-01-08
US7981105B2 (en) 2011-07-19
EP1124608B1 (en) 2005-12-07
US20110238031A1 (en) 2011-09-29
EP2204203A2 (en) 2010-07-07
DK1642615T3 (en) 2011-05-30
AT311925T (en) 2005-12-15
EP1642615B1 (en) 2011-02-16
US9579452B2 (en) 2017-02-28
AU1456700A (en) 2000-05-22
CA2533850C (en) 2009-09-01
JP4267206B2 (en) 2009-05-27
CA2832936A1 (en) 2000-05-11
DE69928827D1 (en) 2006-01-12
AU1330500A (en) 2000-05-22
DK1716884T3 (en) 2014-03-10
EP1642615A3 (en) 2006-08-30
US20090137979A1 (en) 2009-05-28
JP2002528676A (en) 2002-09-03
US20150005716A1 (en) 2015-01-01
CA2346525C (en) 2006-04-11
US8303572B2 (en) 2012-11-06
EP2223713A2 (en) 2010-09-01
EP1642615B2 (en) 2016-12-14
US20020043951A1 (en) 2002-04-18

Similar Documents

Publication Publication Date Title
US9155841B2 (en) Drive mechanism for a drug delivery device
JP4961449B2 (en) Loading mechanism of the infusion pump
US5097122A (en) Medication infusion system having optical motion sensor to detect drive mechanism malfunction
US4498843A (en) Insulin infusion pump
JP4999855B2 (en) Modular portable infusion pump
CA1227391A (en) Portable fluid infusion apparatus
JP5478606B2 (en) Drug delivery device
RU2501575C2 (en) Drug delivery device
US8303535B2 (en) Delivery device for use with a therapeutic drug
US5741232A (en) Front loading medical injector and syringe for use therewith
US6042571A (en) Injection device
EP1009454B1 (en) Dental anesthetic and delivery injection unit
US6190359B1 (en) Method and apparatus for drug infusion
EP2548595B1 (en) Portable infusion pumps of the skin-patch type
US6063059A (en) Medicament dispenser
CA2406026C (en) Improved methods, apparatuses, and uses for infusion pump fluid pressure and force detection
US8257345B2 (en) Reservoir connector
EP2364742B1 (en) Device for delivering medicament
JP5491553B2 (en) Method and apparatus for detecting occlusions in a portable infusion pump
US8858500B2 (en) Engagement and sensing systems and methods
US4828551A (en) Patient controlled analgesia apparatus
EP2162166B1 (en) Infusion pump system with contamination-resistant features
EP2162167B1 (en) Illumination instrument for an infusion pump
US7090662B2 (en) Dose dial and drive mechanisms suitable for use in drug delivery devices
US7736344B2 (en) Infusion medium delivery device and method with drive device for driving plunger in reservoir

Legal Events

Date Code Title Description
ENP Entry into the national phase in:

Ref country code: AU

Ref document number: 2000 14567

Kind code of ref document: A

Format of ref document f/p: F

AK Designated states

Kind code of ref document: A1

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
ENP Entry into the national phase in:

Ref country code: CA

Ref document number: 2345439

Kind code of ref document: A

Format of ref document f/p: F

Ref document number: 2345439

Country of ref document: CA

ENP Entry into the national phase in:

Ref country code: JP

Ref document number: 2000 579280

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 1999971335

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1999971335

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWG Wipo information: grant in national office

Ref document number: 1999971335

Country of ref document: EP