CN108430546B - 用于流体输送的具有减小的死区的医疗装置 - Google Patents

用于流体输送的具有减小的死区的医疗装置 Download PDF

Info

Publication number
CN108430546B
CN108430546B CN201680072022.6A CN201680072022A CN108430546B CN 108430546 B CN108430546 B CN 108430546B CN 201680072022 A CN201680072022 A CN 201680072022A CN 108430546 B CN108430546 B CN 108430546B
Authority
CN
China
Prior art keywords
region
distal
plunger seal
plunger
outlet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201680072022.6A
Other languages
English (en)
Other versions
CN108430546A (zh
Inventor
O·卡比里
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Western Medicine Services Israel Branch
Original Assignee
Western Medicine Services Israel Branch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/269,248 external-priority patent/US10086145B2/en
Application filed by Western Medicine Services Israel Branch filed Critical Western Medicine Services Israel Branch
Publication of CN108430546A publication Critical patent/CN108430546A/zh
Application granted granted Critical
Publication of CN108430546B publication Critical patent/CN108430546B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/001—Apparatus specially adapted for cleaning or sterilising syringes or needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/008—Racks for supporting syringes or needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M5/3134—Syringe barrels characterised by constructional features of the distal end, i.e. end closest to the tip of the needle cannula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202—Devices for protection of the needle before use, e.g. caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202—Devices for protection of the needle before use, e.g. caps
    • A61M5/3204—Needle cap remover, i.e. devices to dislodge protection cover from needle or needle hub, e.g. deshielding devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M5/344—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub using additional parts, e.g. clamping rings or collets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C33/00—Moulds or cores; Details thereof or accessories therefor
    • B29C33/12—Moulds or cores; Details thereof or accessories therefor with incorporated means for positioning inserts, e.g. labels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
    • B65B55/02—Sterilising, e.g. of complete packages
    • B65B55/027—Packaging in aseptic chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
    • B65B55/02—Sterilising, e.g. of complete packages
    • B65B55/04—Sterilising wrappers or receptacles prior to, or during, packaging
    • B65B55/10—Sterilising wrappers or receptacles prior to, or during, packaging by liquids or gases
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D1/00—Containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material, by deep-drawing operations performed on sheet material
    • B65D1/34—Trays or like shallow containers
    • B65D1/36—Trays or like shallow containers with moulded compartments or partitions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D21/00—Nestable, stackable or joinable containers; Containers of variable capacity
    • B65D21/02—Containers specially shaped, or provided with fittings or attachments, to facilitate nesting, stacking, or joining together
    • B65D21/0233—Nestable containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
    • B65D25/02—Internal fittings
    • B65D25/10—Devices to locate articles in containers
    • B65D25/108—Devices, e.g. plates, presenting apertures through which the articles project
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D5/00—Rigid or semi-rigid containers of polygonal cross-section, e.g. boxes, cartons or trays, formed by folding or erecting one or more blanks made of paper
    • B65D5/42—Details of containers or of foldable or erectable container blanks
    • B65D5/44—Integral, inserted or attached portions forming internal or external fittings
    • B65D5/50—Internal supporting or protecting elements for contents
    • B65D5/5028—Elements formed separately from the container body
    • B65D5/503—Tray-like elements formed in one piece
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A61M2005/1581—Right-angle needle-type devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3117—Means preventing contamination of the medicament compartment of a syringe
    • A61M2005/3118—Means preventing contamination of the medicament compartment of a syringe via the distal end of a syringe, i.e. syringe end for mounting a needle cannula
    • A61M2005/312—Means preventing contamination of the medicament compartment of a syringe via the distal end of a syringe, i.e. syringe end for mounting a needle cannula comprising sealing means, e.g. severable caps, to be removed prior to injection by, e.g. tearing or twisting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/31516—Piston or piston-rod constructions, e.g. connection of piston with piston-rod reducing dead-space in the syringe barrel after delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M2005/341—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub angularly adjustable or angled away from the axis of the injector
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3306—Optical measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00—Methods of manufacture, assembly or production
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2209/00—Ancillary equipment
    • A61M2209/04—Tools for specific apparatus
    • A61M2209/045—Tools for specific apparatus for filling, e.g. for filling reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2209/00—Ancillary equipment
    • A61M2209/06—Packaging for specific medical equipment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/1456—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor
    • B29L2031/7544—Injection needles, syringes

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Ceramic Engineering (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

本文公开了一种药物注射筒，其具有带近侧开口的圆筒形膛，注射筒包括膛的远侧壁，所述远侧壁限定从注射筒的中心轴线偏置的出口，并朝向远侧壁的第一区域并且从中心轴线远离与第一区域不同的第二区域偏置；该注射筒包括具有远侧表面的柱塞密封件；其中当所述柱塞密封件被装配到膛中时，远侧表面面向所述膛的所述远侧壁的内表面，内表面的第二区域在平行于圆筒形膛的中心轴线的方向比所述第一区域在轴向上更靠近柱塞密封件的远侧表面，使得流体从第二区域朝向出口排出。

Description

用于流体输送的具有减小的死区的医疗装置
技术领域
本发明在其一些实施例中涉及成角度的注射筒，并且更具体地但非排他地涉及具有减小的流体死区的成角度的注射筒。
背景技术
专利号为6500150的美国专利公开了“一种药物输送装置，其具有限定皮肤接触表面的基座构件、用作药物储存器的注射筒以及用于将药物从注射筒排出的装置。注射筒连接到基座构件，使得注射筒的纵向轴线大致平行于皮肤表面。输送针与注射筒连通。针具有成角度的弯曲，其引导针的尖端基本上垂直于皮肤接触表面。在使用中，针的尖端适于穿透对象的皮肤”。
专利号为6824529的美国专利公开了“一种药物输送装置，其具有限定皮肤接触表面的基座构件、用作药物储存器的注射筒以及用于将药物从注射筒排出的装置。注射筒连接到基座构件，使得注射筒的纵向轴线大致平行于皮肤表面。输送针与注射筒连通。针具有成角度的弯曲，其引导针的尖端基本上垂直于皮肤接触表面。在使用中，针的尖端适于穿透对象的皮肤”。
专利号为6843782的美国专利公开了“一种药物输送装置，其具有限定皮肤接触表面的基座构件、用作药物储存器的注射筒以及用于将药物从注射筒排出的装置。注射筒连接到基座构件，使得注射筒的纵向轴线大致平行于皮肤表面。输送针与注射筒连通。针具有成角度的弯曲，其引导针的尖端基本上垂直于皮肤接触表面。在使用中，针的尖端适于穿透对象的皮肤。”
美国专利5858001公开了“一种液体药物输送装置......”，“其适于通过限定具有粘合涂层的皮肤接触表面的基座构件粘附到对象的皮肤上。圆筒状药筒用作药物的储存器并且被结合在连接到基座构件的壳体中，使得在使用中药筒的纵向轴线基本平行于皮肤接触表面设置。当壳体相对于基座构件向下卡扣时，与药筒内部连通使用的输送针穿透对象的皮肤。该动作还引起柠檬酸/碳酸氢钠气体发生器的启动，其产生气体以移动药筒内的活塞，从而压缩药物隔室。这种压缩导致塞子被与输送针连通的导管穿透，从而允许药物通过针从隔室射出并进入对象的皮下组织。”
公开号20140163526的美国专利公开了“可以装载有标准型注射筒和/或皮下注射针的自动注射装置。可选地，注射筒可以装载有药物和/或覆盖有无菌针头盖。注射筒可以在无菌状态下装入注射器并且针盖体就位。注射器可以包括例如紧固件(例如粘合基座)。在一些实施例中，紧固件可以帮助用户将注射器长时间稳定地保持在患者的皮肤上。例如，注射器可用于在30秒至180秒时间范围内给予0.5至3.0毫升体积范围的注射。”
另外的背景技术包括专利号为6189292、专利公布号为20130253434、专利公布号为2009/093,792、专利号为7967795的美国专利。
发明内容
示例1.一种药物注射筒，具有带近侧开口的圆筒形膛，所述圆筒形膛具有中心轴线，所述注射筒包括：所述膛的远侧壁，其限定出口，所述出口从所述中心轴线朝向所述远侧壁的第一区域偏置并且从中心轴线远离与第一区域不同的第二区域偏置；以及柱塞密封件，所述柱塞密封件的周部的尺寸和形状被设置成适合所述圆筒形膛，所述柱塞密封件与所述圆筒形膛同轴，所述柱塞密封件具有远侧表面；其中当所述柱塞密封件装配到所述膛中时，所述远侧表面面向所述膛的所述远侧壁的内表面，所述内表面的所述第二区域在平行于圆筒形孔的中心轴线的方向上比所述第一区域在轴向更靠近所述柱塞密封件的所述远侧表面。
示例2.示例1的药物注射筒，其中所述内表面的平均方向相对于所述中心轴线倾斜。
例3.示例2的药物注射筒，其中所述内表面的平均方向相对于所述中心轴线以约1度至约5度范围内的角度倾斜。
例4.示例1-3任一项的药物注射筒，其中所述内表面的所述第二区域轴向更靠近所述柱塞密封件的远侧表面，从而允许在远侧表面接触第一区域之前接触柱塞的远侧表面的至少40％。
示例5.示例1-4任一项的药物注射筒，其中柱塞密封件的远侧表面包括凸起形状。
示例6.示例5的药物注射筒，其中所述内壁包括凹陷形状。
示例7.例6的药物注射筒，其中内壁包括圆锥形形状，并且其中内壁的开口角度没有柱塞密封件的远侧表面的凸起形状的开口角度尖锐。
示例8.例1-7中任一项的药物注射筒，其中内表面不是径向对称的。
示例9.示例1-8中任一项的药物注射筒，其中当所述柱塞密封件与所述膛同轴时，所述内表面的第一区域的平均方向远离所述柱塞密封件的远侧表面的平均方向成角度。
示例10.示例1-8中任一项的药物注射筒，其中当所述柱塞密封件与所述膛同轴时，所述内壁的第二区域的平均方向朝向所述柱塞密封件的远侧表面的平均方向成角度。
示例11.示例1-10中任一项所述的药物注射筒，其中所述轴向更靠近包括所述柱塞的远侧表面的平均外边缘与第二区域的平均外边缘之间的距离小于所述柱塞的远侧表面的平均外边缘与第一区域的平均外边缘之间的距离。
示例12.示例1-11中任一项所述的药物注射筒，其中内表面的第一区域的表面和内表面的第二区域的表面之间的过渡是连续的。
示例13.示例1-12中任一项所述的药物注射筒，其中包括偏置流体出口的内壁的第一区域位于膛的边缘附近，并且第二区域位于膛的相对的边缘附近。
示例14.示例1-13中任一项所述的药物注射筒，其中所述药物注射筒还包括源自所述偏置流体出口的弯曲流体路径。
示例15.一种用于减少药物注射筒中的流体死区的方法，所述药物注射筒具有带有近侧开口和远侧偏置流体出口的圆筒形膛，所述圆筒形膛与柱塞密封件配合，所述方法包括：驱动所述柱塞密封件朝向所述圆筒形膛的远端；在与包括所述偏置流体出口的区域不同的接触区域处使所述柱塞密封件的远侧表面的一部分与所述膛的远端的壁的内表面的一部分接触；以及从接触位置朝向偏置流体出口的位置扩大一定范围的接触，同时沿相对于柱塞的远侧表面的平均方向倾斜的平均方向排出流体。
示例16.例15的方法，其中所述接触包括在作为所述内表面的外围边缘的所述接触区域处初始接触，所述外围边缘与包括所述偏置流体出口的区域不同。
示例17.例15的方法，其中在所述接触区域处的所述接触包括在接触包括偏置流体出口的区域之前接触柱塞的远侧表面的至少40％。
示例18.例15-17中任一项所述的方法，其中所述扩大包括扩大从所述外围边缘通过所述内壁的中心部分并到达包括所述偏置流体出口的区域的接触范围。
示例19.例15-18中任一项所述的方法，其中通过使所述柱塞密封件弹性变形来扩大所述接触范围。
示例20.例15-19中任一项所述的方法，其中扩大所述接触范围导致驱动流体远离所述接触位置朝向所述偏置流体出口的位置。
示例21.例15-20中任一项所述的方法，其中所述方法还包括以范围在约5N和约25N之间的力终止所述柱塞密封件的驱动。
示例22.例21的方法，其中在所述终止之后，所述柱塞密封件和所述内壁之间的流体死区的体积范围在约0.01ml和约0.5ml之间。
除非另外定义，否则本文使用的所有技术和/或科学术语具有与本发明所属领域的普通技术人员通常理解的相同的含义。尽管在本发明的实施例的实践或测试中可以使用与本文所述的方法和材料类似或等同的方法和材料，但是下面描述示例性的方法和/或材料。如果发生冲突，将控制包括定义在内的专利说明。另外，这些材料、方法和实例仅是说明性的，并非意在限制。
附图说明
本文仅通过举例的方式参照附图来描述本发明的一些实施例。现在具体参照附图详细说明，需强调所示出的细节是作为示例并且出于对本发明的实施例的说明性讨论的目的。就此而言，对于本领域技术人员而言，利用附图所作的描述对于可以如何实施本发明的实施例是显而易见的。
在附图中：
图1是示出了根据本发明的一些实施例的具有减小的流体死区的注射筒的示意机构的框图；
图2是示出了根据本发明的一些实施例的用于减少注射筒中的流体死区的方法的流程图；
图3是示出了根据本发明的一些实施例的由图2所示的方法产生的流体动力学的流程图；
图4A-4B是本发明的一些实施例中使用的具有偏心流体出口的注射筒的示意图，其中图4A是透视图，图4B是穿过注射筒的背腹(dorsal-ventral)纵向轴线截取的横截面图；
图5A-5E是示出了显示根据本发明的一些实施例的注射筒的横截面的示意图，该注射筒具有在其远端处偏心流体出口以及远端的凹内壁相对于注射筒的纵向轴线的各种定向，其中图5A示出了具有未修改的内壁的注射筒的概况，图5B示出了图5A中的标记区域的放大部分，图5C示出了倾斜的凹内壁，图5D示出了具有倾斜的腹侧部分的凹内壁，以及图5E示出了具有倾斜的背侧部分的凹内壁；
图6是根据本发明的一些实施例的与柱塞密封件接触的倾斜内壁的横截面的示意图；
图7A-7C是根据本发明的一些实施例的包括在倾斜内壁中的倾斜角度的图示，其中图7A示意性地示出了与注射筒的纵向轴线一起的倾斜内壁的横截面，图7B示出了例示不同倾斜角度之间的连续过渡的极坐标图，以及图7C示出了例示不同倾斜角度之间的阶跃过渡(step transition)的极坐标图；以及
图8是示出根据本发明一些实施例的包括可变形平面柱塞和注射筒的倾斜内壁的实施例的透视图的示意图。
具体实施方式
本发明在其一些实施例中涉及成角度的注射筒，并且更具体地但非排他地涉及具有减小的流体死区的成角度的注射筒。
概述
本发明的一个方面涉及一种不对称注射筒，其具有用于容纳流体并具有减小的流体死区的储存器。在一些实施例中，将柱塞密封件装配到注射筒膛中以将流体从所述膛的近侧部分朝向设置在所述膛的远侧部分中的偏心出口流体路径驱动。在一些实施例中，潜在地减少流体死区，储存器的远侧内壁的形状设置为当被柱塞密封件接触时朝着偏心出口流体路径驱动流体。例如，柱塞密封件可以配置成在接触壁的中央部分之前接触储存器的远侧内壁的周界部分，随后接触包含离开膛的流体路径的壁的相对周界部分。可选地，膨胀的柱塞壁接触件朝着非接触部分排出流体，由此消除朝向偏心出口流体路径的流体。
如本文所使用的，术语死区是指一旦柱塞不再能够朝向注射筒的远端进一步被驱动时，保留在医用注射筒内的流体的体积。通常，流体保留在针内和/或注射筒中心和柱塞之间。相对较高的流体死区的潜在缺点包括药物浪费、和/或不准确的剂量和/或潜在的疾病传播。
在一些实施例中，储存器的远侧壁和/或内部远侧壁向包含针的边缘稍微倾斜。可选地，这可以改善到偏心位置的针中的排放。可替换地或另外地，内部远侧壁稍微朝向柱塞倾斜以产生偏移到流体出口的位置的初始接触位置，潜在地导致流体被从偏移位置朝向出口驱动。
在一些实施例中，包括流体储存器的药筒可以被设计成减少死区。例如，柱塞可以由用户将流体从储存器中驱出。例如，柱塞可以朝着储存器的远侧壁驱动流体。可选地，流体可以穿过远侧壁中的开口到达通向注射筒针的延伸部的流体路径。可选地，柱塞可以被设计成初始接触距开口最远的远侧壁的第一部分，并且在朝向壁被驱动时逐渐增加与远侧壁的接触。例如，当柱塞在首次接触壁之后向远侧运动时，壁的增加表面可能接触柱塞。例如，当接触表面增加时，流体可以沿着远侧壁朝着开口被驱动。
在一些实施例中，柱塞由可选地具有旋转推进机构的发动机驱动。标准柱塞可能被设计成从位于中心的出口排出流体。因此，在具有位于中心的出口的标准注射筒中，由最靠近出口的表面限定的柱塞的远侧表面可能围绕膛的中心轴线径向对称，可选地具有标准凸起形状。在一些实施例中，如本申请中提供的注射筒被配置成允许使用具有径向对称性的标准柱塞进行非同心流体排出。
例如，储存器的远侧内壁可以是圆锥形和/或凹陷的，而柱塞密封件可以是锥形的和/或凸起的，其开口角度比注射筒的远侧内壁的开口角度更尖锐。或者，柱塞的远侧表面基本上是平坦的。可选地，注射器的内部远侧壁可以相对于柱塞密封件和/或膛(bore)的轴线成角度。例如，在流体出口侧与柱塞密封件接触之前，膛的远侧内壁可以成角度以在与出口流体路径相对的侧上接触柱塞密封件，例如通过使相对侧沿着注射筒膛的纵向轴线轴向更靠近柱塞远端面。在一些实施例中，内部远侧壁通过使其纵向轴线相对于柱塞的远侧表面的纵向轴线成角度而成角度。例如，内壁的纵向轴线可以以约0.5°至约2°，和/或约2°至约5°，和/或约5°至约10°，和/或更小、更大或中等的任何角度范围成角度。
例如，在大约0-5N和/或大约10-15N之间和/或大约15-25N之间范围的力的作用下，在柱塞朝向圆筒远端壁的行程结束时，柱塞与圆筒远侧壁之间的死区可以在约0.01至0.05和/或约0.05至0.1和/或约0.1至0.5ml之间的范围内。任选地，在延伸部的远侧区段中的储存器与流体路径的出口开口之间的流体路径的体积可以是小的。例如，从储存器到延伸部的开口的流体路径的内部容积可以在0至0.01和/或0.01至0.03和/或0.03至0.06和/或0.06至0.1和/或0.1至0.5ml之间的范围。
在一些实施例中，注射筒膛的内部远侧壁是对称的，可选地围绕圆筒形膛的中心轴线。可选地或另外地，注射筒膛的内部远侧壁不是对称的。可选地，内部远侧壁的仅一部分是成角度的。例如，在一些实施例中，包括流体出口的周部侧从柱塞的远侧表面成角度地倾斜，可选地，当相对的周部侧与柱塞面的轮廓匹配时。可选地，相对的周部侧朝向柱塞面成角度，可选地，当包括流体出口的周部侧与柱塞面的轮廓匹配时。
在一些实施例中，内壁的一部分和/或区域和/或侧面的角度由该区域的平均方向及其相对于膛的中心轴线的倾角和/或倾斜限定。在具有同心出口的典型注射筒中，膛的内部远侧壁的平均方向垂直于膛的中心轴线。在一些实施例中，内部远侧壁倾斜成使得整个内部远侧壁的平均方向相对于中心轴线限定大于90°的角度。可选地，内壁的至少一个区域被成形为基本上配合柱塞远侧表面，而内壁的至少一个不同区域与柱塞的远侧表面成角度远离或朝向柱塞的远侧表面。在一些实施例中，内壁的至少一个区域相对于柱塞的倾斜导致内壁的区域更接近柱塞远侧表面。如本文所使用的，内壁和柱塞有多近，由远侧内壁(或其一部分)的平均外边缘与柱塞远侧表面的平均外边缘之间的距离限定。在一些实施例中，接触区域更靠近柱塞的远侧表面，其被提供为比流体出口区域更近0.05-0.1mm、0.1-0.3mm或0.2-0.4mm的距离或者更大、更小或中间的任何范围。
在一些实施例中，第一区域包括流体出口，并且不同于第一区域的第二区域的形状设置为首先接触柱塞。在一些实施例中，内表面的第二区域轴向更靠近柱塞密封件的远侧表面，使得其允许在远侧表面接触第一区域之前接触柱塞的远侧表面的至少40％。或者，第二区域的接近允许与柱塞密封件的远侧表面接触至少30％、或至少20％、或至少50％。
在一些实施例中，内表面的第二区域包括内表面的80％，不具有流体出口。或者，第二区域包括内表面的至少90％、和/或至少95％、和/或至少99％。在一些实施例中，第一区域包括含有流体出口的连接区域。可选地，第一区域小于远侧表面的2％、和/或小于5％、和/或小于10％。
可选地或另外地，柱塞的远侧表面在以将第一区域与第二区域分开的方式密封至内表面之前从第二区域排出流体。在一些实施例中，提供了内壁的其他不对称配置。例如，在一些实施例中，内壁具有非直角椎体的形状，和/或具有由椎体形结构的组合制成的部分。例如，内壁的第一侧的形状可选地可设置成具有第一顶角的第一锥体的一部分，并且内壁的第二侧的形状可选地可设置成具有第二顶角的第二锥体的一部分。可选地，第一顶角和第二顶角不相同。可选地，由第一锥体和第二锥体的基座限定的直径不同。在一些实施例中，在与流体出口相对的一侧处提供更尖锐的顶角，可能使该侧倾斜以使在该侧具有不太尖锐的顶角之前与该柱塞面接触。在一些实施例中，第一锥体壁和第二锥体壁之间的过渡(transition)是连续的。可选地或另外地，该过渡基本上是一个阶梯过渡。
柱塞密封件可选地具有圆形横截面。例如，柱塞密封件可以由涂覆有PTFE层的氯丁基橡胶和/或溴化丁基橡胶或EPDM或其他合适的密封材料和/或适用于药品和注射的筒材料在产品保质期内使用的材料制成。在一些实施例中，柱塞由基本上可变形的材料制成，被配置成当被压在膛的远侧内壁上并且与其表面匹配时变形。
在一些实施例中，通过模制和/或增加一个层到内部远侧壁的偏移到流体出口的区域来提供与柱塞远侧表面不对称的接触表面。可选地，增加层以形成轴向比包括流体出口的区域更靠近的接触区域。在一些实施例中，增加的层深度在0.05-0.1mm、0.1-0.3mm或0.2-0.4mm的范围内或者更大、更小或中间的任何范围内。可选地，圆筒形注射筒包括右圆筒形主体。或者，注射筒包括非直角圆筒形状。可选地，柱塞密封件具有不均匀的面。例如，柱塞可以不具有围绕其中心轴线的对称表面，例如，柱塞远侧表面的一个区域可以比另一个区域轴向更靠近远侧壁。可能地，在包括不均匀柱塞表面的实施例中，当被推动到远侧壁上时柱塞相对于注射筒不旋转。
在一些实施例中，用于减少流体死区的附加措施包括细流体出口路径。可选地或另外地，通过提供具有相对较小体积的收集器(collect)来减少流体死区，该收集器主要用于在针路径和储存器之间流体连接。
在一些实施例中，当批量生产本文提供的注射筒时，在代表性样品中，至少99％的注射筒和/或至少97％和/或至少90％的注射筒，第二接触区域将在包括流体出口的第一区域之前接触。在一些实施例中，代表性样品包含至少50个注射筒、和/或至少100个注射筒、和/或至少500个注射筒、和/或至少1000个注射筒。
在详细解释本发明的至少一个实施例之前，应当理解的是，本发明在其应用中不一定限于后文描述和/或附图和或示例中阐述的部件的的构造和布置和/或方法的细节。本发明能够具有其他实施例或以各种方式实践或执行。
1.用于减少流体死区的高级机构
现在参照附图，图1示出了说明用于减少注射筒中的流体死区的总体示意性机构的框图，根据本发明的一些实施例，该注射筒具有配合柱塞120的圆筒形膛101并且具有开口的近端107和在其远端105处的偏心流体出口130。
在一些实施例中，通过提供远侧内壁112来减少死区，所述远侧内壁配置成在接触流体出口的位置之前在与流体出口位置偏移的接触位置处与柱塞120的面接触。首先通过接触偏移位置，流体可能被驱向内壁和柱塞之间的未接触空间，非接触空间包括流体出口。
在一些实施例中，内壁112的第一区域114包括流体出口，并且内壁112的第二区域116配置成在第一区域之前接触柱塞120的表面。例如，在一些实施例中第二区域116朝向柱塞120的表面成角度。可选地或另外地，第一区域114远离柱塞120的表面成角度。可选地或另外地，内壁112成角度，使得由内壁横截面限定的平均方向相对于柱塞120面的横截面的平均方向成角度。
2.用于减少死区的示例性方法
现在参考图2，示出了例示根据本发明的一些实施例的用于减少具有偏心流体出口的注射筒中的流体死区的方法的流程图。为了将流体从药筒通过流体出口排出，柱塞密封件被驱动202朝向包含出口的药筒的远侧部分。
减少药筒内剩余流体的一种方法是从不同于包括流体出口的区域的区域收集流体。因此，在一些实施例中，柱塞密封件的远侧表面与药筒的远侧壁的内表面的区域接触，该区域不同于包括偏心出口的区域204。可选地，内表面的尺寸和形状设置为在与出口位置不同的区域更靠近柱塞密封件远侧表面。
在一些实施例中，通过将柱塞沿着出口的方向驱动来扩大柱塞表面与内壁的朝向出口的接触范围206。在一些实施例中，为了接触增加的内壁部分，柱塞相对于远侧壁的内表面弹性变形。
在一些实施例中，出口区域的不同区域位于出口的相对部分，例如，如果出口位于限定为药筒的背侧部分的边缘附近，则不同区域可以在药筒的腹侧部分的范围内。可选地或另外地，不同区域可以比出口更靠近药筒边缘。例如，如果出口位于药筒的背侧部分附近，出口和背侧边缘之间的区域可以被认为是不同的，并且在一些实施例中，该不同区域的形状可设置成比出口区域更靠近柱塞。可选地，在柱塞接触包括偏置流体出口的区域之前，不同区域接触柱塞的远侧表面的至少20％、和/或至少30％、和/或至少40％、和/或至少50％。
3.由减少死区配置导致的潜在流体路径
现在参考图3，其例示了根据本发明的一些实施例的由图1中示出的配置和/或图2中示例的方法导致的可能的流体动力学路径。
一旦柱塞被朝向药筒的远侧部分驱动302，则包含在药筒中的流体朝向药筒远侧壁被排出304，可选地通过药筒的偏心出口排出。在一些实施例中，只要柱塞被朝向远侧边缘驱动，包括当柱塞的远侧表面最初在不同于出口的区域的区域处接触药筒远侧壁的内表面时，流体就从药筒中排出306。
在一些实施例中，当流体被驱动从初始接触位置离开并朝向出口位置时，流体继续在柱塞表面与远侧壁的内表面初始接触之后排出308，可选地通过使柱塞变形以扩大其接触范围。在一些实施例中，在柱塞与远侧壁的一部分初始接触更靠近它时，在远侧壁的方向上施加力时，柱塞变形。由于闭合部分的机械障碍，柱塞的接触部分不能再前进，但是在一些实施例中，柱塞远侧表面在被强压到远侧壁上时弹性变形，导致接触范围增加。
在一些实施例中，远侧内壁的平均方向导致流体沿着该方向排出，该方向相对于柱塞的远侧表面的平均方向倾斜。
4.具有偏心流体出口的药物输送装置的示例性配置和尺寸
现在参考图4，其示意性地示出了例如在药物输送装置中有用并且在本发明的一些实施例中使用的不对称注射器的示例。
本文提供了例如注射筒409的药物输送药筒的典型和/或示例性尺寸。在一些实施例中，储存器和/或空腔432(例如在注射筒409中)的有效载荷可以包括例如在0.5和2ml之间和/或在2和7ml之间和/或在7和6ml之间和/或在7和10ml之间的药物和/或安慰剂和/或任何生物活性和/或非生物活性物质。在一些实施例中，注射器可以将整个有效载荷作为单剂量卸载。药物输送装置可以包括例如贴片注射器和/或内部供电的驱动器以驱动柱塞和/或卸载有效载荷。
用于该申请，内部供电的注射器驱动器可以被限定为由至少暂时存储在注射器内的能量驱动的驱动机构。电力可以存储在电源中，例如作为化学能(例如产生膨胀气体和/或电池的化学制品)和/或机械能(例如存储在弹性构件和/或弹簧和/或加压气体中)。例如，驱动器可以被设计成在20至120秒和/或120至600秒和/或600秒至1小时之间和/或1小时至一天和/或更长的时间段内卸载有效载荷。
一般来说，卸载可能由驱动器驱动。内部供电的驱动器可以由各种机构供电，包括例如所讨论的马达，包括例如DC马达、致动器、无刷马达和/或包括例如伸缩组件和/或螺纹元件的变速器、和/或齿轮和/或联轴器和/或弹性机构(例如弹簧和/或橡胶带)和/或膨胀气体和/或液压致动器。
根据本发明的一些实施例的药物输送装置可以包括所讨论的储存器部分。例如，储存器可以包括药物容器和/或注射筒。可选地，可以使用标准设备和/或在无菌室给注射筒预装载药物。预装载注射筒可以可选地包括近侧开口。柱塞可以可选地密封近侧开口和/或保护注射筒的内容物的无菌性。通常为空心的无菌针头可以可选地连接到注射筒膛。例如，针的中空部可以与膛的内部流体连通。针可以可选地刚性地附接到膛的远端处的延伸部。
在一些实施例中，柱塞可以沿膛的内部轴向滑动以卸载药物有效载荷。例如，药物可以通过中空针头卸载。针的突出尖端可以与膛的轴线成一定角度定向。
任选地，注射药物所需的力(例如在注射筒柱塞上的力)可以在例如5至60N之间。例如，注射药物所需的力取决于注射速率和/或药物的粘度和/或注射筒几何形状和/或针的尺寸。
例如，药物输送装置可以包括自动注射器。自动注射器可以通过用足够的力手动推动以插入针来启动。该装置然后可以施加注射力以注射药物。一旦全部药物被注射和/或当存在阻碍和/或闭塞时，注射力可能上升，直至其通过阈值，从而触发针头保护和/或结束注射。
例如，如果发生闭塞和/或输送结束，设备产生的线性力可能会增加到最高60N的水平。针防护机构(例如针缩回机构)可能对力敏感。例如，该机构可以包括卡扣，该卡扣在70N时使针返回到缩回位置。
在一些实施例中，注射药物和/或触发针的安全保护的应力可以包括扭矩。例如，药物的注射可能由柱塞驱动。柱塞可以可选地由螺纹组件例如螺纹螺钉和/或齿和/或伸缩组件驱动。可选地，齿和/或相关联的螺钉的螺距可以在例如0.5和2mm之间的范围内。螺钉的直径可以在例如2.5和15mm之间的范围内。用于动力注射的扭矩可以在例如0.2和1.0N*cm之间的范围内。在注射期间，柱塞的线性运动可以在例如10-50mm之间的范围内。柱塞的运动的长度可以例如随着待注射的药物的体积而变化，其可以例如在0.5至3ml之间。
在一些实施例中，储存器可具有例如在20和72之间和/或72和78mm和/或78和80mm和/或80和200mm范围内的长度。在一些实施例中，储存器的内部圆筒形空间可具有例如在1和3mm之间和/或3和10和/或10和15mm和/或15和25mm和/或25和50mm之间的平均宽度。可选地，储存器可以具有圆形横截面，使得宽度是圆的直径。在一些实施例中，延伸部可具有直线端部，其具有例如在1和3mm或3和7mm或7和8或8和10mm或10和15mm或15和50mm之间的长度。在一些实施例中，针的暴露的笔直部分可具有例如1至5mm或5至7mm或7至10mm或10至20mm之间的长度。
在一些实施例中，延伸部和储存器空腔之间的流体路径可以包括27号针或范围在25至30号之间的针或范围在20至25号之间的针或范围在30至32号之间的针。在一些实施例中，从延伸部突出的针可以包括27号针或范围在25至30号之间的针或范围在20至25号之间的针或范围在30至32号之间的针。
现在参考图4B，其示意性地示出了根据本发明的一些实施例的设计用于减少死区的膛的横截面。在一些实施例中，连接在膛442的空腔432和毂(hub)436之间的流体路径450可以穿过和/或被模铸到注射筒409中。可选地(例如，如图4B所示)，金属针452形成流体路径450的一部分。可选地，通过在针452内部具有整个路径来减少流体路径450中的死区(减少塑料模具中的死区)。例如，针452的嵌入部分453形成至突出部分451的弯曲流体路径450。突出部分451可选地直接伸出毂436，与空腔的轴线458和/或膛442的轴线458基本成直角。可选地针体452的突出端为倾斜和/或削尖以便于穿过对象的皮肤插入。
在一些实施例中，减小将针452的端部约束在空腔432内的端部安装件的尺寸以减小模铸后留下的死区。可选地，端部安装件可以包括销和/或收集器(collect)。例如，收集器可具有握住针452的端部的凹面和/或圆锥形内表面。可选地或附加地，销可以具有能装入到针452的中空部中的凸面和/或圆锥形表面和/或在插入时自对准。例如，销可以包括能装入到针452中的内凸部和/或定位针体452的外凹部。在模铸之前，销的外凹部可定位针452以将销的内凸部插入针452的中空部中。然后，外凹部可在成型之前缩回。可选地，在模制期间，只有销的内部保留在模具中。在模铸之后，可选地移除内销，当药物从注射器排出时留下减小的死区。
5.示例性的远侧内壁配置
图5A-5E举例说明了根据本发明的一些实施例的用于远侧内壁的可能配置，从而导致柱塞-壁接口可能地减少流体死区。
为了说明目的和描绘有用的轴线定义，图5A和5B示意性地示出了具有膛的药物注射筒，该膛具有形状被设置成配合柱塞远侧表面的内部远侧壁，两者均具有基本上非倾斜和对齐的平均方向，其中图5B是图5A中的标记圆圈区域的放大图。
图5A示意性地示出了上述注射筒的一个实例的横截面的侧视图。在一些实施例中，注射筒包括配合柱塞密封件470的圆筒形膛442。可选地，膛具有开口的近端440。在一些实施例中，在其远端438处，膛442包括具有内表面488的壁，可选地，内表面488具有与远端438的外表面不同的轮廓和/或横截面。在一些实施例中，膛442包括偏心流体出口456，可选地流体地连接储存器432与路径450，路径450可选地相对于膛442的中心轴线458弯曲。在一些实施例中，路径450弯曲使得针尖451指向膛442的腹侧439b。可选地，为了允许用于弯曲路径450的尽可能多的空间，偏心流体出口被偏置到膛442的背侧。
在一些实施例中，柱塞470包括具有接口的远侧表面475，所述接口的尺寸和形状设置为接触内表面488的至少一部分。可选地，内表面488的形状设置为使得初始柱塞内表面接触位置偏移到流体出口的位置。在一些实施例中，远侧表面475是凸起的。在一些实施例中，内表面488是凹入的。在一些实施例中，由内表面488限定的打开角度与由远侧表面475限定的打开角度基本相同。
下面参考图5B-5E描述内表面488关于其与远侧表面475匹配的各种区域，其具有各种倾斜角度和/或凹陷和/或平均方向。
图5B示出了不成角度的示例，示出了图5A中标记的圆形区域的放大图。示例内表面488的两个不同区域484和482的平均方向584和582。在图5B的不成角度示例中，内表面488具有与柱塞远侧表面475的平均方向一致的平均方向。更具体地说，当柱塞远侧表面475围绕中心轴线458对称时，在该示例中，背侧区域482和腹侧区域484具有相同的平均方向584和582，这些平均方向584和582也与远侧表面475的背侧部分和腹侧部分的平均方向一致。
图5C示出了背侧区域482和腹侧区域484的倾斜。所示出的是背侧区域482相对于原始平均方向582以角度A倾斜。还示出腹侧区域484相对于原始平均方向584以角度B倾斜。在一些实施例中，包括出口的区域，例如在该实施例中区域482，远离柱塞倾斜，而与包括出口的区域不同的区域，例如在该实施例中区域484，朝向柱塞倾斜。可选地，角度A和B是相同的。或者，角度A和B以不同程度倾斜。在一些实施例中，区域482和/或区域484具有弯曲的背腹横截面。优选地但不是强制的，区域482和/或484的曲线是凹的，从柱塞弯曲离开，可能地地防止更多的死区。
图5D示出了仅腹侧区域484以角度B倾斜。在所示实施例中，区域484不同于包括出口456的区域。通常期望流体将从围绕出口484的区域排出，并且因此在一些实施例中，区域484朝向柱塞表面475倾斜，可能地首先接触其表面并且朝向出口区域482驱动流体离开。
图5E示出了仅背侧区域482以角度A倾斜。在所示实施例中，区域482包括出口456。因为通常期望流体将从围绕出口484的区域排出，所以在该实施例中，区域482远离柱塞表面475倾斜，导致区域484更靠近柱塞表面475并且可能首先与柱塞表面475接触。
6.减少死区的柱塞接口
图6是根据本发明的一些实施例的注射筒的远侧部分609的横截面图，其具有成角度的内部远侧壁678和安装在圆筒形空腔432上的偏离中心的成角度的毂436。例如，流体路径可以在偏心出口456的位置处连接到膛442的空腔432。在一些实施例中，柱塞密封件670的远侧表面可以具有凸起的基本圆锥形状和开口角度668。在一些实施例中，圆筒形空腔432的远侧壁的内表面678可以具有基本凹入的圆锥形状和开口角度666。可选地，柱塞密封件的远侧表面的开口角度668可以比圆筒形空腔432的内部远侧壁678的开口角度666更尖锐。可选地，圆筒形空腔432的内部远侧壁678可以相对于柱塞密封件670的远侧表面成角度，例如，内部远侧壁678可以具有偏移到由柱塞密封件670的远侧表面限定的平均方向的平均方向。为了更好地示出模制特征，形成流体路径450的边界的可选针452未在图6中示出。
在一些实施例中，特征可被配置成避免流体被捕获在远侧柱塞密封件670和圆筒形空腔432的内部远侧壁678之间的死区中。例如，柱塞密封件670的远侧表面的形状和/或空腔432的远侧内壁678的形状可配置成当柱塞密封件670接近空腔432的内部远侧壁时将流体推向流体路径450的开口。例如，在一些实施例中，在流体路径450在空腔432的外部边缘附近连接到空腔432的情况下，柱塞密封件的远侧表面的开口角度668可以比圆筒形空腔432的内部远侧壁678的开口角度666更尖锐。例如，柱塞密封件670的远侧表面的开口角度可以在小于0至1度和/或小于1至3度和/或小于1至5度和/或小于5至10度和/或比空腔432的远侧壁678的开口角度小10至30度。可选地或另外地，在流体路径450在空腔432的轴线458附近连接到空腔432(例如如图5所示)的一些实施例中，柱塞密封件的远侧表面的开口角度668可以不如圆筒形空腔432的内部远侧壁678的开口角度666那样尖锐。
在一些实施例中，在流体路径450连接到空腔432的外边缘附近的空腔432的情况下，连接到流体路径450的圆筒形空腔432的内部远侧壁678可以成角度远离远侧柱塞密封件670。例如，柱塞密封件670和/或其远侧表面可以与圆筒形空腔432的轴线458对齐，而锥形远侧内壁678的轴线680处于轴线458和/或柱塞密封件670的轴线和/或柱塞密封件670的锥形面的轴线的0至0.1度之间的角度和/或0.1至1度之间和/或1至3度之间和/或3至10度之间和/或10至30度之间的角度。可选地或另外地，远侧内壁678可以不是正圆锥形和/或可以不是圆锥形和/或可以不是对称的。例如，流体路径450可以连接到中心和外边缘之间的内部远侧壁678和/或连接到路径450的内部远端壁678的部分可以相对于内部远侧壁678的其余部分略微向远侧凹入，导致平均方向582相对于由柱塞密封件670的远侧表面的外部限定的轴线671倾斜角度α。在一些实施例中，α具有0至0.1度和/或0.1至1度和/或1至3度和/或3至10度和/或10至30度之间的范围。例如，在一些实施例中，流体路径450可以在空腔432的背侧439a附近连接。然后，内部远侧壁678的轴线可选地相对于轴线458和/或柱塞密封件670的锥形面的轴线以正角度倾斜。
在一些实施例中，当插入空腔432中时，柱塞密封件670可以围绕轴线458基本对称。例如，柱塞密封件670可以具有与空腔432的内侧壁接触的密封表面672和/或稳定表面674。可选地，柱塞密封件670可以包括柱塞驱动器安装件676。柱塞驱动器安装件676可选地与空腔432同轴。
在一些实施例中，对于偏离中心的流体路径，柱塞密封件670的远侧表面可以具有凹陷的基本圆锥形状，并且圆柱形空腔432的内部远侧壁678可以具有基本上凸起的圆锥形状。可选地，柱塞密封件的远侧表面的开口角度可以不如圆筒形空腔432的内部远侧壁678的开口角度那样尖锐。
7.可变角度的壁
现在参考图7，其示出了根据本发明的一些实施例的相对于注射筒膛的中心纵向轴线具有可变角度的壁。
图7A示出了根据本发明的一些实施例的内表面488，其具有背侧439a和腹侧439b并且具有围绕轴线458限定可变角度的壁。在一些实施例中，限定为包括出口456的区域的所述内表面的第一区域482的形状设置成具有顶角2β的第一锥体的一部分，以及限定为与出口区域不同的区域的所述内表面的第二区域484的形状设定成具有顶角2α的第二锥体的一部分。在一些实施例中，中心轴线458分割每个顶点，使得区域482的平均方向与轴线458之间的角度处于角度β，并且区域484的平均方向与轴线458之间的角度处于角度α。在一些实施例中，第二锥体具有比第一锥体更尖锐的顶角，即α<β。
图7B和图7C示出极坐标图，其示出了在所述内表面的第一区域482和所述内表面的第二区域484之间发现的过渡部702a和702b，其中点C对应于背侧439a以及点G对应于腹侧439b。在一些实施例中，区域482与区域484之间的过渡是连续的，如图7B所示。可选地或另外地，区域482和区域484之间的过渡是不连续的，并且可选地具有基本上是阶梯图(stepgraph)的形状。在一些实施例中，一侧(例如A)中的区域482与区域484之间的过渡与另一侧(例如B)中的过渡相同，至少在背腹线上保持对称性。或者，每一侧的过渡都不相同。
8.平面柱塞密封件
图8示意性地说明了根据本发明的一些实施例的具有柱塞密封件870的药物注射筒800，柱塞密封件870具有平坦远侧表面875。在一些实施例中，注射筒800包括用于容纳流体的药筒842，其具有远端838，终止于包括背侧882和腹侧884的内部远侧表面888。在一些实施例中，靠近背侧882的流体出口856位于相对于中心轴线858偏心位置。可选地，流体通过出口856排出并且通过流体路径850出去。
在一些实施例中，为了朝向出口856驱动流体，同时具有减少的残留在药筒842中的流体，并且特别在内表面888和柱塞表面875之间的空间中，表面888的腹侧部分884朝向表面875倾斜。可选地或另外地，背侧882远离表面875倾斜。倾斜导致内表面888的平均方向982偏移到柱塞表面875的平均方向887。
9.概括
可以预料，在从本申请成为专利期间，将开发许多相关的注射筒装置，术语注射筒和/或药筒的范围旨在预先包括所有这些新技术。
如本文所用，术语“约”是指±25％。
术语“包括”、“包括有”、“包含”、“包含于”、“具有”及其结合意味着“包括但不限于”。
术语“由...组成”表示“包括并限于”。
术语“基本上由...组成”是指组合物、方法或结构可以包括附加的成分、步骤和/或部分，但仅指附加成分、步骤和/或部分不会实质上改变要求保护的组合物、方法或结构的基本特征和新颖特征。
如本文所用，除非上下文另外明确指出，否则单数形式“一”，“一个”和“该”包括复数指代。
贯穿本申请，本发明的各种实施例可以以范围格式呈现。应该理解的是，范围形式的描述仅仅是为了方便和简洁，并且不应该被解释为对本发明范围的不灵活的限制。因此，范围的描述应被视为具体公开了所有可能的子范围以及该范围内的单个数值。例如，从1到6的范围的描述应该被认为具有特定公开的子范围，例如从1到3、1到4、1到5、2到4、2到6、3至6等，以及该范围内的个别数字，例如1、2、3、4、5和6。无论范围的宽度如何，这都适用。
无论何时在此指出数字范围，其意图包括在所指示的范围内的任何引用的数字(分数或整数)。第一指示数字和第二指示数字之间的“范围/范围之间”和“范围/范围从”第一指示数字“到”第二指示数字在本文中可互换使用，并且意在包括第一和第二指示数字以及它们之间的所有分数和整数数字。
如本文所使用的，术语“方法”是指用于完成给定任务的方式、手段、技术和程序，包括但不限于由化学、药理学、生物学、生物化学和医学领域的从业人员已知或易于从已知方式、手段、技术和程序开发的那些方式、手段、技术和程序。
应该认识到，为了清楚起见，在单独实施例的上下文中描述的本发明的某些特征也可以在单个实施例中组合提供。相反地，为了简洁起见，在单个实施例的上下文中描述的本发明的各种特征也可以单独地或以任何合适的子组合或者在本发明的任何其他描述的实施例中合适地提供。除非实施例在没有那些元件的情况下不起作用，否则在各种实施例的上下文中描述的某些特征不被认为是那些实施例的基本特征。
虽然已经结合其具体实施例描述了本发明，但对于本领域技术人员而言，许多替代、修改和变化将是显而易见的。因此，旨在涵盖落入所附权利要求的精神和广泛范围内的所有这些替代、修改和变化。
本说明书中提及的所有出版物、专利和专利申请在此通过引用整体并入本说明书，其程度如同每个单独的出版物、专利或专利申请被具体和单独地指出通过引用并入本文。另外，本申请中任何参考文献的引用或标识不应被解释为承认这种参考文献可作为本发明的现有技术。在使用章节标题的范围内，不应将其解释为限制。

Claims (18)

1.一种药物注射筒，其特征在于，所述药物注射筒包括：
具有近侧开口的圆筒形膛，具有内表面的远侧壁以及中心轴线，所述内表面具有第一区域和不同于所述第一区域的第二区域，所述第一区域限定了所述内表面的整个背侧，所述第二区域限定了所述内表面的整个腹侧，所述圆筒形膛的所述远侧壁限定出口，所述出口从所述中心轴线朝向所述第一区域偏置并且远离所述第二区域被偏置；以及
柱塞密封件，所述柱塞密封件具有尺寸和形状设置成配合在所述圆筒形膛中的周部，所述柱塞密封件与所述圆筒形膛同轴，所述柱塞密封件具有远侧表面；
其中所述内表面不是径向对称的，包括所述出口的所述内表面的所述第一区域位于所述膛的边缘附近，并且所述第二区域位于所述膛的相对的边缘附近，
其中当所述柱塞密封件装配到所述圆筒形膛中时，所述远侧表面面向所述圆筒形膛的所述远侧壁的所述内表面，所述内表面的所述第二区域在平行于所述圆筒形膛的所述中心轴线的方向上比所述第一区域轴向更靠近所述柱塞密封件的所述远侧表面，从而在所述远侧表面接触所述第一区域之前允许所述柱塞密封件的所述远侧表面在初始接触位置接触所述第二区域，从而将流体从所述初始接触位置驱至所述出口，并且
其中所述柱塞密封件被配置为弹性变形，以从所述第二区域向所述第一区域扩展接触范围。
2.根据权利要求1所述的药物注射筒，其特征在于，所述内表面的平均方向相对于所述中心轴线倾斜。
3.根据权利要求2所述的药物注射筒，其特征在于，所述内表面的所述平均方向相对于所述中心轴线以1度至5度范围内的角度倾斜。
4.根据权利要求1-3任一项所述的药物注射筒，其特征在于，所述柱塞密封件的所述远侧表面包括凸起形状。
5.根据权利要求4所述的药物注射筒，其特征在于，所述内表面包括凹陷形状。
6.根据权利要求5所述的药物注射筒，其特征在于，所述内表面包括圆锥形形状，并且其中所述内表面的开口角度没有所述柱塞密封件的所述远侧表面的所述凸起形状的开口角度尖锐。
7.根据权利要求1-3中任一项所述的药物注射筒，其特征在于，当所述柱塞密封件与所述膛同轴时，所述内表面的所述第一区域的平均方向远离所述柱塞密封件的所述远侧表面的平均方向成角度。
8.根据权利要求1-3中任一项所述的药物注射筒，其特征在于，当所述柱塞密封件与所述膛同轴时，所述内表面的所述第二区域的平均方向朝向所述柱塞密封件的所述远侧表面的平均方向成角度。
9.根据权利要求1-3中任一项所述的药物注射筒，其特征在于，所述柱塞密封件的所述远侧表面的平均外边缘与所述第二区域的平均外边缘之间的距离小于所述柱塞密封件的所述远侧表面的平均外边缘与所述第一区域的平均外边缘之间的距离。
10.根据权利要求1-3中任一项所述的药物注射筒，其特征在于，所述内表面的所述第一区域的表面和所述内表面的所述第二区域的表面之间的过渡是连续的。
11.根据权利要求1-3中任一项所述的药物注射筒，其特征在于，所述药物注射筒还包括源自所述出口的弯曲流体路径。
12.一种用于非治疗目的的减小药物注射筒中的流体死区的方法，其特征在于，所述药物注射筒为根据权利要求1所述的药物注射筒，所述方法包括：
朝向所述圆筒形膛的远端驱动所述柱塞密封件；
使所述柱塞密封件的远侧表面的一部分与所述圆筒形膛的所述远端的壁的内表面的一部分在与包括所述出口的区域不同的接触区域接触；以及
从所述接触位置朝向所述出口的位置扩大接触区域，同时沿平均方向排出流体，所述平均方向相对于柱塞密封件的所述远侧表面的平均方向倾斜，
其中在所述接触区域的所述接触包括在接触包括所述出口的所述区域之前接触所述柱塞密封件的所述远侧表面。
13.根据权利要求12所述的方法，其特征在于，所述接触包括在作为所述内表面的外周边缘的所述接触区域处初始接触，所述外周边缘与包括所述出口的区域不同。
14.根据权利要求13所述的方法，其特征在于，所述扩大包括扩大从所述外周边缘通过所述内表面的中心部分并到达包括所述出口的区域的接触范围。
15.根据权利要求12-13中任一项所述的方法，其特征在于，通过使所述柱塞密封件弹性变形来扩大所述接触范围。
16.根据权利要求12-13中任一项所述的方法，其特征在于，扩大所述接触范围导致驱动流体朝向所述出口的位置远离所述接触位置。
17.根据权利要求12-13中任一项所述的方法，其特征在于，所述方法还包括以范围在5N和25N之间的力终止所述柱塞密封件的驱动。
18.根据权利要求17所述的方法，其特征在于，在所述终止之后，所述柱塞密封件和内壁之间的流体死区的体积范围在0.01ml和0.5ml之间。
CN201680072022.6A 2015-10-09 2016-10-10 用于流体输送的具有减小的死区的医疗装置 Active CN108430546B (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201562284806P 2015-10-09 2015-10-09
US62/284,806 2015-10-09
US201662281536P 2016-01-21 2016-01-21
US62/281,536 2016-01-21
US15/204,542 2016-07-07
US15/204,542 US10576207B2 (en) 2015-10-09 2016-07-07 Angled syringe patch injector
US15/269,248 2016-09-19
US15/269,248 US10086145B2 (en) 2015-09-22 2016-09-19 Rotation resistant friction adapter for plunger driver of drug delivery device
PCT/US2016/056218 WO2017062932A1 (en) 2015-10-09 2016-10-10 Medical device for fluid delivery having reduced dead space

Publications (2)

Publication Number Publication Date
CN108430546A CN108430546A (zh) 2018-08-21
CN108430546B true CN108430546B (zh) 2021-04-09

Family

ID=65014324

Family Applications (7)

Application Number Title Priority Date Filing Date
CN201680059090.9A Active CN108367114B (zh) 2015-10-09 2016-10-10 具有流体路径和驱动器的注射设备
CN201680072023.0A Active CN108697863B (zh) 2015-10-09 2016-10-10 注射器针帽脱离器
CN201610882938.XA Active CN106964013B (zh) 2015-10-09 2016-10-10 成角度的注射器修补注入器
CN202110939202.2A Pending CN114344609A (zh) 2015-10-09 2016-10-10 筒和制造筒的方法
CN201680072188.8A Active CN108430547B (zh) 2015-10-09 2016-10-10 保护针尖
CN201680072344.0A Active CN108430537B (zh) 2015-10-09 2016-10-10 具有滑动运动副的贴片式注射器
CN201680072022.6A Active CN108430546B (zh) 2015-10-09 2016-10-10 用于流体输送的具有减小的死区的医疗装置

Family Applications Before (6)

Application Number Title Priority Date Filing Date
CN201680059090.9A Active CN108367114B (zh) 2015-10-09 2016-10-10 具有流体路径和驱动器的注射设备
CN201680072023.0A Active CN108697863B (zh) 2015-10-09 2016-10-10 注射器针帽脱离器
CN201610882938.XA Active CN106964013B (zh) 2015-10-09 2016-10-10 成角度的注射器修补注入器
CN202110939202.2A Pending CN114344609A (zh) 2015-10-09 2016-10-10 筒和制造筒的方法
CN201680072188.8A Active CN108430547B (zh) 2015-10-09 2016-10-10 保护针尖
CN201680072344.0A Active CN108430537B (zh) 2015-10-09 2016-10-10 具有滑动运动副的贴片式注射器

Country Status (5)

Country Link
US (13) US10576207B2 (zh)
EP (9) EP3359222B1 (zh)
JP (6) JP6571878B2 (zh)
CN (7) CN108367114B (zh)
WO (7) WO2017062931A1 (zh)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1762259B1 (en) 2005-09-12 2010-09-08 Unomedical A/S Inserter for an infusion set with a first and second spring units
KR20130018783A (ko) 2010-03-30 2013-02-25 우노메디컬 에이/에스 의료기구
US10194938B2 (en) 2011-03-14 2019-02-05 UnoMedical, AS Inserter system with transport protection
EP2583715A1 (en) 2011-10-19 2013-04-24 Unomedical A/S Infusion tube system and method for manufacture
CN107683158B (zh) 2015-06-04 2021-05-14 麦迪麦珀医疗工程有限公司 用于药物释放装置的筒插入
US10576207B2 (en) * 2015-10-09 2020-03-03 West Pharma. Services IL, Ltd. Angled syringe patch injector
WO2017125817A1 (en) 2016-01-19 2017-07-27 Unomedical A/S Cannula and infusion devices
CN113041432B (zh) 2016-01-21 2023-04-07 西医药服务以色列有限公司 包括视觉指示物的药剂输送装置
US11504482B2 (en) * 2017-03-08 2022-11-22 Peter A. Sirianni Precision steerable and angled medication delivery system
US10918754B2 (en) 2017-03-27 2021-02-16 Regeneron Pharmaceuticals, Inc. Sterilisation method
EP4062957A1 (en) * 2017-05-05 2022-09-28 Regeneron Pharmaceuticals, Inc. Auto-injector
CN114259626B (zh) * 2017-08-30 2024-06-21 比罗埃特医药公司 紧凑型自动注射器
EP3681562B1 (en) * 2017-09-15 2020-12-23 West Pharma. Services Il, Ltd. Patch injector
JP7198809B2 (ja) * 2017-09-21 2023-01-04 ウェスト ファーマ サービシーズ イスラエル リミテッド 注射器の注射針挿入機構
US11738148B2 (en) * 2017-10-30 2023-08-29 Press-Q Low profile intuitive pharmaceutical injection device
CN114470420A (zh) 2017-12-22 2022-05-13 西氏医药包装(以色列)有限公司 适用于不同尺寸的药筒的注射器
JPWO2019189436A1 (ja) * 2018-03-30 2021-03-25 テルモ株式会社 薬液投与装置
US20210022797A1 (en) * 2018-04-04 2021-01-28 E.S.I Novel Ltd. Device and cartridge for skin treatment
WO2019229719A1 (en) * 2018-06-01 2019-12-05 Sun Pharma Advanced Research Company Limited An injection device
WO2020176818A1 (en) 2019-02-28 2020-09-03 Tissuecor, Llc Graft tissue injector
CN113950341B (zh) 2019-05-20 2024-03-19 优诺医疗有限公司 可旋转的输注装置及其方法
CN110916843A (zh) * 2019-12-19 2020-03-27 深圳市智屏微科技有限公司 断喙注射装置
WO2022008233A1 (en) 2020-07-06 2022-01-13 Shl Medical Ag Activation and detection system for a supplemental device attached to a medicament delivery device
WO2022148207A1 (en) * 2021-01-05 2022-07-14 Medtrum Technologies Inc. Enhanced drug infusion device
US20230060227A1 (en) * 2021-09-01 2023-03-02 Tissuecor, Llc Device and system for injecting biological tissue
KR20230059438A (ko) * 2021-10-26 2023-05-03 메디허브 주식회사 주사기용 앰플캡
USD1007676S1 (en) 2021-11-16 2023-12-12 Regeneron Pharmaceuticals, Inc. Wearable autoinjector
EP4311565A1 (en) * 2022-07-26 2024-01-31 SCHOTT Pharma Schweiz AG Glass syringe barrel with increased flange breaking resistance

Family Cites Families (879)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1321550A (en) 1919-11-11 Syringe
US232432A (en) 1880-09-21 Coupling for tubes
US1125887A (en) 1914-04-08 1915-01-19 Gustav R Schimmel Hypodermic syringe.
US1704921A (en) 1924-02-11 1929-03-12 Carl C Quale Capsule for hypodermic syringes
US1795530A (en) 1928-01-06 1931-03-10 Watson Waddell Ltd Machine for thrashing and scutching flax
US1795630A (en) 1928-04-24 1931-03-10 Raymond M Ramsey Screw jack
US2453590A (en) 1946-11-04 1948-11-09 Noel J Poux Hypodermic syringe
NL72855C (zh) 1949-11-25
US2702547A (en) 1950-02-27 1955-02-22 Antonina S Glass Motor-driven medical injection apparatus and cartridges therefor
DE855313C (de) 1950-03-31 1952-11-13 August Stoeckert Injektionsspritze
US2677373A (en) 1952-05-19 1954-05-04 P M Ind Inc Plastic injection device
DE1064693B (de) 1956-03-08 1959-09-03 Josef Klinger Vorrichtung zum selbsttaetigen Einstechen einer Injektionsnadel
US2860635A (en) 1957-03-20 1958-11-18 Edgar H Wilburn Sterilizable and sterilized hypodermic syringe assemblies
GB999506A (en) 1960-11-02 1965-07-28 Engis Ltd Improvements in syringes for dispensing paste or the like
US3203269A (en) 1962-10-22 1965-08-31 Lockheed Aircraft Corp Telescoping screw sequencing device
US3623474A (en) 1966-07-25 1971-11-30 Medrad Inc Angiographic injection equipment
US3585439A (en) 1969-06-10 1971-06-15 Westinghouse Electric Corp A camera tube with porous switching layer
BE756550A (fr) 1969-09-23 1971-03-01 Sherwood Medical Ind Inc Seringue a chargement par l'arriere et procede pour son remplissage
US3708945A (en) 1971-01-06 1973-01-09 Upjohn Co Syringe assembling method and machine
US3834387A (en) 1972-08-10 1974-09-10 Sherwood Medical Ind Inc Breech loaded syringe with deformable piston
US3794028A (en) 1973-02-27 1974-02-26 A Griffin Method for injecting chemicals into the papilla for depilation
US3994295A (en) 1975-08-22 1976-11-30 Wulff Goldwyn L Hypodermic syringe needle mounting
DE7603096U1 (de) 1976-02-04 1976-08-19 Espe Pharm Praep Vorrichtung zur dosierten Abgabe viskoser Massen
US4273122A (en) 1976-11-12 1981-06-16 Whitney Douglass G Self contained powered injection system
US4085747A (en) 1976-12-13 1978-04-25 Milstein Medical Research Foundation, Inc. Infusion pumps and dosage control means therefor
US4195636A (en) 1978-03-27 1980-04-01 Behnke Robert C Arm flesh injection site clamp
US4218724A (en) 1978-11-21 1980-08-19 Kaufman Lance R Compact circuit package having improved circuit connectors
US4324262A (en) 1979-01-02 1982-04-13 University Of Virginia Alumni Patents Foundation Aspirating culture catheter and method of use
DE2906830C2 (de) 1979-02-22 1981-07-16 B. Braun Melsungen Ag, 3508 Melsungen Gerät für Dauerinfusionen
US4241381A (en) 1979-04-04 1980-12-23 Amp Incorporated Bus bar assembly for circuit cards
US4254768A (en) 1979-09-14 1981-03-10 Ty Perla J Hypodermic syringe
US4403987A (en) 1982-01-25 1983-09-13 Gottinger Company, Inc. Device for aiding injection of a hypodermic syringe
US4435173A (en) 1982-03-05 1984-03-06 Delta Medical Industries Variable rate syringe pump for insulin delivery
US4425120A (en) 1982-04-15 1984-01-10 Sampson Norma A Shielded hypodermic syringe
US4465478A (en) 1982-10-14 1984-08-14 Collagen Corporation Syringe force amplification device
DE3367854D1 (en) 1982-10-27 1987-01-15 Duphar Int Res Automatic injection device
US4710178A (en) * 1982-11-03 1987-12-01 Micro-Mega S.A. Precision injection system and method for intraligmental anesthesia
HU189198B (en) * 1982-12-10 1986-06-30 Adorjan,Andras,Hu Plastic syringe for single use as well as plastic piston particularly for plastic syringes
US4504263A (en) 1982-12-22 1985-03-12 Valleylab, Inc. Flow rate monitor with optical sensing chamber
US4502488A (en) 1983-01-13 1985-03-05 Allied Corporation Injection system
ATE57612T1 (de) 1983-05-20 1990-11-15 Bengt Gustavsson Anordnung zur uebertragung einer substanz.
EP0143895B1 (de) 1983-09-07 1987-12-23 Disetronic Ag Tragbares Infusionsgerät
FR2556214B1 (fr) 1983-12-08 1986-08-14 Merieux Inst Procede de preparation en serie de seringues auto-injectables contenant un medicament lyophilise et dispositif de mise en oeuvre de ce procede
US4549554A (en) 1984-01-03 1985-10-29 Markham Charles W Aspiration biopsy device
US4685903A (en) 1984-01-06 1987-08-11 Pacesetter Infusion, Ltd. External infusion pump apparatus
US4583974A (en) 1984-04-04 1986-04-22 Kokernak Denis T Syringe for balloon dilation catheters
US4601702A (en) 1984-05-21 1986-07-22 Quest Medical, Inc. Volumetric infusion actuator
US4599082A (en) 1984-08-13 1986-07-08 Becton, Dickinson And Company Two-component syringe assembly
US4810215A (en) 1985-06-06 1989-03-07 Yazaki Corporation Position compensating connector
FR2589215B1 (fr) 1985-10-29 1989-05-05 Thomson Csf Joint electrique entre parois conductrices, orthogonales, independantes
US4636201A (en) 1985-11-01 1987-01-13 American Hospital Supply Corporation Hypodermic syringe having a protective sheath cover
US4695274A (en) 1986-01-31 1987-09-22 Fox Richard L Protected hypodermic needle
DE3606163A1 (de) 1986-02-26 1987-08-27 Hoechst Ag Vorrichtung zur applikation von arzneimittelsuspensionen
US4664654A (en) 1986-03-07 1987-05-12 Strauss Eric C Automatic protracting and locking hypodermic needle guard
US4735311A (en) 1986-04-09 1988-04-05 The West Company Needle shield assembly
US4702738A (en) 1986-05-22 1987-10-27 Spencer Treesa A Disposable hypodermic syringe and needle combination having retractable, accident preventing sheath
DE3638984C3 (de) 1986-11-14 1993-11-18 Haselmeier Wilhelm Fa Injektionsgerät
US4698055A (en) 1986-11-24 1987-10-06 Sealfon Andrew I Hypodermic syringe
US4867743A (en) 1986-11-24 1989-09-19 Vaillancourt Vincent L Ambulatory disposable infusion delivery system
GB8630016D0 (en) 1986-12-16 1987-01-28 Id Tech Ltd Dental injection device
CA1283827C (en) 1986-12-18 1991-05-07 Giorgio Cirelli Appliance for injection of liquid formulations
US4882575A (en) 1987-01-28 1989-11-21 Sharp Kabushiki Kaisha Monitor for blocked condition in tube for fluid infusion pump
US4737144A (en) 1987-03-09 1988-04-12 Choksi Pradip V Syringe with selectively exposed and enveloped needle
US4810249A (en) 1987-03-12 1989-03-07 Habley Medical Technology Corp. Linear and Vernier-type syringe
CA1285441C (en) 1987-03-17 1991-07-02 Roy D. Mcnaughton Mcnaughton syringe shield type b
US4758231A (en) 1987-04-27 1988-07-19 Habley Medical Technology Corporation Shielded safety syringe
NL8701091A (nl) 1987-05-08 1988-12-01 Spruyt Hillen Bv Injectiepen.
US4772272A (en) 1987-05-11 1988-09-20 Mcfarland Barton C Needle protective sleeve
US5080648A (en) 1987-06-08 1992-01-14 Antonio Nicholas F D Hypodermic fluid dispenser
US4813426A (en) 1987-11-09 1989-03-21 Habley Medical Technology Corporation Shielded safety syringe having a retractable needle
US4919596A (en) 1987-12-04 1990-04-24 Pacesetter Infusion, Ltd. Fluid delivery control and monitoring apparatus for a medication infusion system
CH675078A5 (zh) 1988-01-22 1990-08-31 Nosta Ag
US4863434A (en) * 1988-01-29 1989-09-05 Bayless William B Automatic needle sheath for disposable syringe
US4840185A (en) 1988-02-17 1989-06-20 Manuel Hernandez Blood sampling device with shield
US4923446A (en) 1988-04-14 1990-05-08 Page Mary J Shield for devices capable of penetrating skin
US4897083A (en) 1988-05-09 1990-01-30 Martell Michael D Syringe needle guard
JPH056995Y2 (zh) 1988-05-27 1993-02-23
US5147326A (en) 1988-06-28 1992-09-15 Sherwood Medical Company Combined syringe and needle shield and method of manufacture
US5156599A (en) 1988-06-28 1992-10-20 Sherwood Medical Company Syringe and sliding locking needle shield
US5088988A (en) 1988-06-28 1992-02-18 Sherwood Medical Company Combined dental syringe and needle shield
US5127910A (en) 1988-06-28 1992-07-07 Sherwood Medical Company Combined syringe and needle shield and method of manufacture
US5217437A (en) 1988-06-28 1993-06-08 Sherwood Medical Company Needle protecting device
US5131816A (en) 1988-07-08 1992-07-21 I-Flow Corporation Cartridge fed programmable ambulatory infusion pumps powered by DC electric motors
US4861341A (en) * 1988-07-18 1989-08-29 Woodburn Robert T Subcutaneous venous access device and needle system
US4892521A (en) 1988-08-03 1990-01-09 Lincoln Mills, Inc. Protective cover for hypodermic needle
US4929241A (en) 1988-08-05 1990-05-29 Kulli John C Medical needle puncture guard
US4900310A (en) 1988-10-07 1990-02-13 International Medication Systems Limited Protective device for cannula used to draw blood
US4919569A (en) 1988-11-10 1990-04-24 Wittenzellner Siegfried Process for disposing of waste
US4950241A (en) 1988-12-27 1990-08-21 Sherwood Medical Company Disposable syringe
DK68789A (da) 1989-02-14 1990-08-15 Novo Nordisk As Injektionspen
US5019051A (en) 1989-03-02 1991-05-28 Needlepoint Guard, Inc. Hypodermic needle guard
US5062828A (en) 1989-03-13 1991-11-05 Waltz Roger L Hypodermic syringe
IT1231916B (it) 1989-05-29 1992-01-15 Ampliscientifica S R L Pancreas artificiale indossabile
US4998924A (en) 1989-07-25 1991-03-12 Sherwood Medical Company Double sleeve safety syringe
USD322671S (en) 1989-11-22 1991-12-24 Becton, Dickinson And Company Needle shield or the like
US4964866A (en) 1989-11-22 1990-10-23 Becton, Dickinson And Company Needle sheath assembly
US5109850A (en) 1990-02-09 1992-05-05 Massachusetts Institute Of Technology Automatic blood monitoring for medication delivery method and apparatus
US4994045A (en) 1990-04-20 1991-02-19 Sherwood Medical Company Split sleeve safety syringe
US5624400A (en) 1990-05-09 1997-04-29 Safety Syringes, Inc. Disposable self-shielding aspirating syringe
US5051109A (en) 1990-07-16 1991-09-24 Simon Alexander Z Protector for catheter needle
US5190521A (en) 1990-08-22 1993-03-02 Tecnol Medical Products, Inc. Apparatus and method for raising a skin wheal and anesthetizing skin
TW279133B (zh) 1990-12-13 1996-06-21 Elan Med Tech
US5527288A (en) 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
US5298023A (en) 1991-03-08 1994-03-29 Habley Medical Technology Corporation Multiple pharmaceutical dispenser with accumulator
WO1992017131A1 (en) 1991-03-29 1992-10-15 Collagen Corporation Device and method for treating facial lines
JPH0562828A (ja) 1991-08-30 1993-03-12 Railway Technical Res Inst 可動式磁場低減装置
DK175491D0 (da) 1991-10-18 1991-10-18 Novo Nordisk As Apparat
AT397467B (de) * 1991-10-22 1994-04-25 Wimmer Erwin Einwegspritze
US5300119A (en) 1992-01-10 1994-04-05 Hansa Medical Products, Inc. Delivery system
US5269762A (en) 1992-04-21 1993-12-14 Sterling Winthrop, Inc. Portable hand-held power assister device
US5295966A (en) 1992-04-29 1994-03-22 Becton, Dickinson And Company Syringe pump with biased lockable syringe clamp
US5282593A (en) 1992-06-05 1994-02-01 Tri W-G, Inc. Adjustable leg
WO1993025841A1 (de) 1992-06-15 1993-12-23 Max Wyssmann Vorrichtung zur gezielten, steuerbaren abgabe einer flüssigkeit oder einer viskosen masse
US5254096A (en) 1992-09-23 1993-10-19 Becton, Dickinson And Company Syringe pump with graphical display or error conditions
US5246670A (en) 1992-09-23 1993-09-21 Habley Medical Technology Corporation Pharmaceutical mixing container with buoyant mixing element
US5376785A (en) 1992-10-02 1994-12-27 Chin; Philip K. Optical displacement sensor utilizing optical diffusion
IL107038A (en) 1992-10-05 1997-04-15 Senetek Plc Medicament injectors and methods for injection using same
US5267977A (en) 1992-10-29 1993-12-07 Feeney Jr Richard J No-stick syringe
US5342313A (en) 1992-11-02 1994-08-30 Infusion Technologies Corporation Fluid pump for a flexible, variable geometry reservoir
US5496274A (en) 1992-11-23 1996-03-05 Becton, Dickinson And Company Locking safety needle assembly
CH685461B5 (fr) 1993-01-05 1996-01-31 Jean Claude Berney Dispositif portable de perfusion de substances therapeutiques liquides et ensembles comprenant un tel dispositif.
DK0681558T3 (da) 1993-01-29 1998-01-05 Schering Plough Healthcare Stabile sulfidsammensætninger, anvendelser deraf og fremgangsmåde til fremstilling deraf
AU682670B2 (en) 1993-02-05 1997-10-16 Becton Dickinson & Company Syringe needle isolation device
US5383865A (en) 1993-03-15 1995-01-24 Eli Lilly And Company Medication dispensing device
US5894015A (en) 1993-04-07 1999-04-13 Rechtin; Michael D. Disinfection of medical sharps
US5300045A (en) 1993-04-14 1994-04-05 Plassche Jr Walter M Interventional needle having an automatically capping stylet
JP3199524B2 (ja) 1993-08-06 2001-08-20 日本メジフィジックス株式会社 ルアーニードルユニット及び注射器
US5338311A (en) 1993-08-23 1994-08-16 Mahurkar Sakharam D Hypodermic needle assembly
FR2710537B1 (fr) 1993-09-30 1995-12-01 Becton Dickinson Co Procédé et dispositif de détection d'occlusions dans une ligne de perfusion.
USD356150S (en) 1993-10-04 1995-03-07 Abbott Laboratories Container closure with drip chamber
SE9303568D0 (sv) 1993-10-29 1993-10-29 Kabi Pharmacia Ab Improvements in injection devices
US5348544A (en) * 1993-11-24 1994-09-20 Becton, Dickinson And Company Single-handedly actuatable safety shield for needles
JP3223684B2 (ja) 1993-12-31 2001-10-29 ニプロ株式会社 薬液注入器具
US5478316A (en) * 1994-02-02 1995-12-26 Becton, Dickinson And Company Automatic self-injection device
US5645955A (en) 1994-02-15 1997-07-08 Mag Instrument, Inc. Battery
US5804331A (en) 1994-02-15 1998-09-08 Mag Instrument, Inc. Battery device
US5522804A (en) 1994-02-15 1996-06-04 Lynn; Lawrence A. Aspiration, mixing, and injection syringe
US5482446A (en) 1994-03-09 1996-01-09 Baxter International Inc. Ambulatory infusion pump
US5536249A (en) 1994-03-09 1996-07-16 Visionary Medical Products, Inc. Pen-type injector with a microprocessor and blood characteristic monitor
US5415645A (en) 1994-04-29 1995-05-16 Friend; John M. Retractable sheath for hypodermic needle
EP0680767A1 (en) 1994-05-06 1995-11-08 Nardino Righi Non-reusable safety syringe
DE19518807A1 (de) 1994-05-30 1995-12-07 Carlos Maria Baron Hypodermische Einwegspritze
US5478315A (en) 1994-08-08 1995-12-26 Brothers Family Investments, L.C. Local anesthetic injection system
US5658256A (en) 1994-08-22 1997-08-19 Shields; Jack W. Universal sharps shield
CN1063670C (zh) * 1994-09-07 2001-03-28 陈隆雄 一种安全型注射器
US5505709A (en) 1994-09-15 1996-04-09 Minimed, Inc., A Delaware Corporation Mated infusion pump and syringe
US5609580A (en) 1994-09-16 1997-03-11 Vital Signs, Inc. Injection holder for a plungerless syringe and combination plungerless syringe and injection holder
GB9419316D0 (en) 1994-09-24 1994-11-09 Robertson William F A needle guard
US7027859B1 (en) 1994-09-26 2006-04-11 Alza Corporation Electrotransport delivery device having improved safety and reduced abuse potential
US5456360A (en) * 1994-09-30 1995-10-10 The Perkin-Elmer Corporation Holder assembly for reaction tubes
CA2159052C (en) 1994-10-28 2007-03-06 Rainer Alex Injection device
IE72524B1 (en) 1994-11-04 1997-04-23 Elan Med Tech Analyte-controlled liquid delivery device and analyte monitor
US5743879A (en) 1994-12-02 1998-04-28 Science Incorporated Medicament dispenser
US5637095A (en) 1995-01-13 1997-06-10 Minimed Inc. Medication infusion pump with flexible drive plunger
GB9501218D0 (en) 1995-01-21 1995-03-15 Boc Group Plc Medical devices
US5690618A (en) 1995-02-22 1997-11-25 Mark Timothy Smith Electronic syringe
US5647853A (en) 1995-03-03 1997-07-15 Minimed Inc. Rapid response occlusion detector for a medication infusion pump
IL114960A0 (en) 1995-03-20 1995-12-08 Medimop Medical Projects Ltd Flow control device
US5562686A (en) 1995-04-19 1996-10-08 United States Surgical Corporation Apparaus and method for suturing body tissue
ATE255926T1 (de) 1995-04-20 2003-12-15 Acist Medical Sys Inc Selbsttätig sich reinigender injektor für die angiographie
GB9511169D0 (en) 1995-06-02 1995-07-26 Lilly Co Eli Containers for liquid medicaments
CA2151407A1 (en) 1995-06-09 1996-12-10 Duncan Newman Injection device
WO1997000091A1 (fr) 1995-06-14 1997-01-03 Berney Jean Claude Piston de seringue avec transmission lineaire
US5645530A (en) 1995-08-28 1997-07-08 Alcon Laboratories, Inc. Phacoemulsification sleeve
NZ318852A (en) 1995-09-11 1998-10-28 Elan Med Tech Medicament delivery device includes a reservoir, driving means and a hollow needle which extends through the periphery of the skin contacting surface
IE77523B1 (en) 1995-09-11 1997-12-17 Elan Med Tech Medicament delivery device
US6277095B1 (en) 1995-10-11 2001-08-21 Science Incorporated Fluid delivery device with full adapter
US5776103A (en) 1995-10-11 1998-07-07 Science Incorporated Fluid delivery device with bolus injection site
US5989221A (en) 1995-10-20 1999-11-23 Pharmacia & Upjohn Ab Arrangement in electronically controlled injection devices
US5697916A (en) 1995-11-21 1997-12-16 Stat Medical Devices Inc. Hypodermic dosage measuring device
US5858001A (en) 1995-12-11 1999-01-12 Elan Medical Technologies Limited Cartridge-based drug delivery device
US5830187A (en) 1995-12-22 1998-11-03 Science Incorporated Fluid delivery device with conformable ullage and fill assembly
ATE494027T1 (de) 1996-03-12 2011-01-15 Novo Nordisk As Injektionsvorrichtung mit elektronischer anzeige der gewählten dosis
GB9606829D0 (en) 1996-03-30 1996-06-05 Jeffrey Peter Supplying materials etc
US7468055B2 (en) 1996-06-20 2008-12-23 Becton Dickinson And Company Multi-beveled point needle and syringe having a multi-beveled point needle
US5665075A (en) * 1996-07-03 1997-09-09 Becton, Dickinson And Company Method of making a needle shield assembly
US5681295A (en) * 1996-07-03 1997-10-28 Becton, Dickinson And Company Needle shield assembly having a single-use cannula lock
GB2350317B (en) * 1996-07-15 2001-01-10 Star Syringe Ltd Apparatus for making syringes
US5858008A (en) 1997-04-22 1999-01-12 Becton, Dickinson And Company Cannula sealing shield assembly
JP3531149B2 (ja) 1996-07-31 2004-05-24 ニプロ株式会社 採血針廃棄容器
USD393314S (en) 1996-08-28 1998-04-07 Medisense, Inc. Meter for analysis of blood constituents
JP3035448U (ja) 1996-09-04 1997-03-18 株式会社ジーシー 歯周ポケット用薬剤注入器
US6146361A (en) 1996-09-26 2000-11-14 Becton Dickinson And Company Medication delivery pen having a 31 gauge needle
US5697908A (en) 1996-09-26 1997-12-16 Becton Dickinson France, S.A. Lockable safety shield for a prefillable syringe
US5662678A (en) 1996-10-11 1997-09-02 Macklin; John W. Self injection arm clamp
US5868710A (en) 1996-11-22 1999-02-09 Liebel Flarsheim Company Medical fluid injector
US5766186A (en) 1996-12-03 1998-06-16 Simon Fraser University Suturing device
JP2001511033A (ja) 1997-02-04 2001-08-07 ノボ ノルディスク アクティーゼルスカブ 液状薬剤懸濁液の投与装置
US5851197A (en) 1997-02-05 1998-12-22 Minimed Inc. Injector for a subcutaneous infusion set
US7899511B2 (en) 2004-07-13 2011-03-01 Dexcom, Inc. Low oxygen in vivo analyte sensor
DE19717107B4 (de) 1997-04-23 2005-06-23 Disetronic Licensing Ag System aus Behältnis und Antriebsvorrichtung für einen Kolben, der in dem ein Medikamentfluid enthaltenden Behältnis gehalten ist
US6530900B1 (en) 1997-05-06 2003-03-11 Elan Pharma International Limited Drug delivery device
US6186982B1 (en) 1998-05-05 2001-02-13 Elan Corporation, Plc Subcutaneous drug delivery device with improved filling system
DK0981343T3 (da) 1997-05-14 2006-01-30 Atherogenics Inc Probucolmonoestere til behandling af kardiovaskulær og inflammatorisk sygdom
US6558351B1 (en) 1999-06-03 2003-05-06 Medtronic Minimed, Inc. Closed loop system for controlling insulin infusion
US6500150B1 (en) 1997-06-16 2002-12-31 Elan Pharma International Limited Pre-filled drug-delivery device and method of manufacture and assembly of same
WO1998057683A1 (en) 1997-06-16 1998-12-23 Elan Corporation, Plc. Pre-filled drug-delivery device and method of manufacture and assembly of same
US5961496A (en) 1997-06-17 1999-10-05 Novo Nordisk A/S Syringe with tiltable nut for quick piston disengagement
US5968011A (en) 1997-06-20 1999-10-19 Maersk Medical A/S Subcutaneous injection set
JP2001509426A (ja) 1997-07-11 2001-07-24 ノボ ノルディスク アクティーゼルスカブ 医療用具の設定の表示のための装置
US5944699A (en) 1997-08-11 1999-08-31 Barrelle; Laurent Pre-assembled syringe
US5810784A (en) 1997-08-15 1998-09-22 Tamaro; Frank A. Safety cap assembly for needles and catheters
CN1127357C (zh) * 1997-09-16 2003-11-12 黄吴顺 具定位的静脉注射安全针筒
US6004296A (en) 1997-09-30 1999-12-21 Becton Dickinson France, S.A. Lockable safety shield assembly for a prefillable syringe
FR2770136B1 (fr) 1997-10-27 2000-03-10 Njc Innovations Dispositif d'administration de substances therapeutiques a seringue motorisee
US5984697A (en) 1997-12-03 1999-11-16 Qualcomm Incorporated Ground clip apparatus for circuit boards
US6033245A (en) 1997-12-05 2000-03-07 Simplex Time Recorder Co. Self-aligning electrical connector
WO1999033504A1 (en) 1997-12-31 1999-07-08 Minimed Inc. Insertion device for an insertion set and method of using the same
US6079979A (en) * 1998-01-28 2000-06-27 Ultradent Products, Inc. Endonontic irrigator tips and kits
US5926596A (en) 1998-01-28 1999-07-20 The Whitaker Corporation Overmolded alignment ferrule
DE69900026T2 (de) 1998-01-30 2001-05-10 Novo Nordisk As Eine injektionsspritze
US5957895A (en) 1998-02-20 1999-09-28 Becton Dickinson And Company Low-profile automatic injection device with self-emptying reservoir
US5954697A (en) 1998-03-02 1999-09-21 Srisathapat; Chad Threaded nut syringe plunger for use with a medication infusion pump
EP1433705B1 (en) 1998-03-13 2015-07-22 Becton Dickinson and Company Method for manufacturing, filling and packaging medical containers
US6186979B1 (en) * 1998-03-16 2001-02-13 Edward D. Dysarz One-handed retractable blood collection device with trap-in container
WO1999048546A1 (en) 1998-03-23 1999-09-30 Elan Corporation, Plc Drug delivery device
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US5919167A (en) 1998-04-08 1999-07-06 Ferring Pharmaceuticals Disposable micropump
US6200289B1 (en) 1998-04-10 2001-03-13 Milestone Scientific, Inc. Pressure/force computer controlled drug delivery system and the like
TW406018B (en) 1998-05-21 2000-09-21 Elan Corp Plc Improved adhesive system for medical devices
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US5941850A (en) 1998-06-29 1999-08-24 Shah; Binod Safety cannula
US6554798B1 (en) 1998-08-18 2003-04-29 Medtronic Minimed, Inc. External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities
US5993423A (en) 1998-08-18 1999-11-30 Choi; Soo Bong Portable automatic syringe device and injection needle unit thereof
JP2000107289A (ja) 1998-10-05 2000-04-18 Showa Yakuhin Kako Kk カートリッジ式歯科用注射器ユニット
US6064797A (en) 1998-10-12 2000-05-16 B. Braun Medical, Inc. Volumetric flow equalizing drive control wheel
SE9803662D0 (sv) 1998-10-26 1998-10-26 Pharmacia & Upjohn Ab Autoinjector
US7193521B2 (en) 1998-10-29 2007-03-20 Medtronic Minimed, Inc. Method and apparatus for detecting errors, fluid pressure, and occlusions in an ambulatory infusion pump
US6817990B2 (en) 1998-10-29 2004-11-16 Medtronic Minimed, Inc. Fluid reservoir piston
US6800071B1 (en) 1998-10-29 2004-10-05 Medtronic Minimed, Inc. Fluid reservoir piston
US7621893B2 (en) 1998-10-29 2009-11-24 Medtronic Minimed, Inc. Methods and apparatuses for detecting occlusions in an ambulatory infusion pump
US20050197626A1 (en) 1998-10-29 2005-09-08 Medtronic Minimed Inc. Fluid reservoir for use with an external infusion device
US20020173748A1 (en) 1998-10-29 2002-11-21 Mcconnell Susan Reservoir connector
EP1124600B1 (en) 1998-10-29 2005-02-23 Medtronic MiniMed, Inc. Compact pump drive system
US6248093B1 (en) 1998-10-29 2001-06-19 Minimed Inc. Compact pump drive system
US7766873B2 (en) 1998-10-29 2010-08-03 Medtronic Minimed, Inc. Method and apparatus for detecting occlusions in an ambulatory infusion pump
US6907679B2 (en) * 1998-11-12 2005-06-21 Qlt Usa, Inc. Method for lyophilizing an active agent
JP2002529204A (ja) 1998-11-13 2002-09-10 エラン・フアルマ・インターナシヨナル・リミテツド 薬品を給送するシステム及び方法
US6162197A (en) 1998-12-22 2000-12-19 Mohammad; Owais Retractable needle assembly and method of making the same
US20010018937A1 (en) 1998-12-28 2001-09-06 Shigeru Nemoto Method and device for pre-filling a syringe with a contrast agent
US6645177B1 (en) 1999-02-09 2003-11-11 Alaris Medical Systems, Inc. Directly engaged syringe driver system
US6423029B1 (en) 1999-04-29 2002-07-23 Medtronic, Inc. System and method for detecting abnormal medicament pump fluid pressure
US6336729B1 (en) 1999-05-20 2002-01-08 Richard Pavelle Emergency light device
US6458102B1 (en) 1999-05-28 2002-10-01 Medtronic Minimed, Inc. External gas powered programmable infusion device
US7806886B2 (en) 1999-06-03 2010-10-05 Medtronic Minimed, Inc. Apparatus and method for controlling insulin infusion with state variable feedback
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6752787B1 (en) 1999-06-08 2004-06-22 Medtronic Minimed, Inc., Cost-sensitive application infusion device
US6270481B1 (en) 1999-06-16 2001-08-07 Breg, Inc. Patient-controlled medication delivery system
US6277099B1 (en) 1999-08-06 2001-08-21 Becton, Dickinson And Company Medication delivery pen
US6377848B1 (en) 1999-08-25 2002-04-23 Vyteris, Inc. Devices activating an iontophoretic delivery device
US6224569B1 (en) 1999-09-24 2001-05-01 Becton, Dickinson And Company Compact needle point shield
AU7839900A (en) 1999-09-29 2001-04-30 Sterling Medivations, Inc. Reusable medication delivery device
US20020193740A1 (en) 1999-10-14 2002-12-19 Alchas Paul G. Method of intradermally injecting substances
US6383173B1 (en) * 1999-10-22 2002-05-07 Roy H. Hunt Syringe drench adapter for livestock
US7063684B2 (en) 1999-10-28 2006-06-20 Medtronic Minimed, Inc. Drive system seal
US6394984B1 (en) 1999-10-28 2002-05-28 Frank C Hill Syringe
US6673033B1 (en) 1999-11-24 2004-01-06 Medrad, Inc. Injectors, injector systems and injector control
US6958053B1 (en) 1999-11-24 2005-10-25 Medrad, Inc. Injector providing drive member advancement and engagement with syringe plunger, and method of connecting a syringe to an injector
US6520930B2 (en) 1999-11-24 2003-02-18 Medrad, Inc. Injectors, injector systems and injector control
US6302633B1 (en) 1999-12-17 2001-10-16 L. Richard Poe Multiple pitch threaded fastener apparatus
US20030060765A1 (en) 2000-02-16 2003-03-27 Arthur Campbell Infusion device menu structure and method of using the same
DE10012575A1 (de) 2000-03-15 2001-09-27 Schott Glas Transportvorrichtung für medizinische Behälter
AU2001250924A1 (en) 2000-03-22 2001-10-03 Docusys, Inc. A drug delivery and monitoring system
US20010041869A1 (en) 2000-03-23 2001-11-15 Causey James D. Control tabs for infusion devices and methods of using the same
US6485465B2 (en) 2000-03-29 2002-11-26 Medtronic Minimed, Inc. Methods, apparatuses, and uses for infusion pump fluid pressure and force detection
US6836687B2 (en) 2000-03-31 2004-12-28 Medtronic, Inc. Method and system for delivery of a medical electrical lead within a venous system
US6485461B1 (en) 2000-04-04 2002-11-26 Insulet, Inc. Disposable infusion device
US6716198B2 (en) 2000-05-18 2004-04-06 Novo Nordisk A/S Injection device
SE0001893D0 (sv) 2000-05-22 2000-05-22 Pharmacia & Upjohn Ab Medical arrangement
US6511336B1 (en) 2000-05-25 2003-01-28 Illinois Tool Works Inc. Solderless flex termination for motor tab
DE10026172A1 (de) 2000-05-26 2001-11-29 Roche Diagnostics Gmbh System zur Entnahme von Körperflüssigkeit
US6517517B1 (en) 2000-06-08 2003-02-11 Mayo Foundation For Medical Education And Research Automated injection device for administration of liquid medicament
US7530964B2 (en) 2000-06-30 2009-05-12 Elan Pharma International Limited Needle device and method thereof
AUPQ867900A0 (en) 2000-07-10 2000-08-03 Medrad, Inc. Medical injector system
US6589229B1 (en) 2000-07-31 2003-07-08 Becton, Dickinson And Company Wearable, self-contained drug infusion device
US6986760B2 (en) 2000-08-02 2006-01-17 Becton, Dickinson And Company Pen needle and safety shield system
US6554800B1 (en) 2000-08-09 2003-04-29 Medtronic Minimed, Inc. Compact pump motor system and dispensing process
WO2003015847A1 (en) 2000-08-17 2003-02-27 Milestone Scientific Inc. Local anesthetic and delivery injection unit with automated rate control
CN1471413A (zh) 2000-09-08 2004-01-28 用于患者注射的装置、系统和方法
US20040260233A1 (en) 2000-09-08 2004-12-23 Garibotto John T. Data collection assembly for patient infusion system
EP1332440B1 (en) 2000-10-04 2012-04-11 Insulet Corporation Data collection assembly for patient infusion system
JP2002191695A (ja) 2000-10-20 2002-07-09 Mitsubishi Pencil Co Ltd 針先カバー部材、針先カバー部材付き注射針の組立方法、針ガード部材付き注射針および針ガード部材付き注射器
JP2004512100A (ja) 2000-10-27 2004-04-22 ノボ　ノルディスク　アクティーゼルスカブ 入れ子式ピストンロッドを有する薬剤吐出装置
US6508788B2 (en) 2000-10-27 2003-01-21 Novo Nordisk A/S Medication delivery device with telescopic piston rod
US6572604B1 (en) 2000-11-07 2003-06-03 Baxter International Inc. Occlusion detection method and system for ambulatory drug infusion pump
ES2300082T3 (es) 2000-11-09 2008-06-01 Insulet Corporation Medio de suministro transcutaneo.
ES2717656T3 (es) 2000-11-30 2019-06-24 Valeritas Inc Dispositivo con microsonda amovible sustancialmente libre sobre el alojamiento
USD461243S1 (en) 2000-12-04 2002-08-06 Bracco Diagnostics Inc. Ellipsoidal syringe barrel
US20020086036A1 (en) 2000-12-05 2002-07-04 Allergan Sales, Inc. Methods for treating hyperhidrosis
JP2004532664A (ja) 2000-12-21 2004-10-28 インシュレット コーポレイション 医療機器の遠隔制御装置及び方法
US6387078B1 (en) 2000-12-21 2002-05-14 Gillespie, Iii Richard D. Automatic mixing and injecting apparatus
IT1320868B1 (it) 2000-12-29 2003-12-10 Cane Srl Dispositivo portatile per infusione di farmaci.
US6666821B2 (en) 2001-01-08 2003-12-23 Medtronic, Inc. Sensor system
US6743237B2 (en) 2001-01-17 2004-06-01 Innon Holdings, Llc Endoscopic stone extraction device with improved basket
DE10101932A1 (de) 2001-01-17 2002-07-25 Disetronic Licensing Ag Ansaugstück für eine oder an einer Vorrichtung zur Verabreichung eines injizierbaren Produkts
US7018363B2 (en) 2001-01-18 2006-03-28 Medrad, Inc. Encoding and sensing of syringe information
US6905298B1 (en) 2001-02-08 2005-06-14 Joseph E. Haring Telescopic nut
US6749587B2 (en) 2001-02-22 2004-06-15 Insulet Corporation Modular infusion device and method
US20040034331A1 (en) 2001-02-23 2004-02-19 Jason Toman Integrated medication delivery system
EP1379291A4 (en) 2001-02-23 2008-09-24 Stryker Instr INTEGRATED DRUG DELIVERY SYSTEM
AUPR373001A0 (en) 2001-03-14 2001-04-12 Glenord Pty Ltd Improved non-reusable syringe
GB0107604D0 (en) 2001-03-27 2001-05-16 Dca Design Int Ltd Improvements in and relating to injection device
WO2002081024A1 (en) 2001-04-04 2002-10-17 Alza Corporation Transdermal electrotransport delivery device including an antimicrobial compatible reservoir composition
US6595960B2 (en) 2001-04-12 2003-07-22 Becton, Dickinson And Company Flexible needle assembly
WO2002083206A2 (en) 2001-04-13 2002-10-24 Nipro Diabetes Systems Infusion set with tape
US6854620B2 (en) 2001-04-13 2005-02-15 Nipro Diabetes, Systems, Inc. Drive system for an infusion pump
JP4283545B2 (ja) 2001-05-16 2009-06-24 イーライ リリー アンド カンパニー リセット簡易化式駆動アセンブリー付きの薬物注射装置
US8034026B2 (en) 2001-05-18 2011-10-11 Deka Products Limited Partnership Infusion pump assembly
US20120209197A1 (en) 2002-01-04 2012-08-16 Lanigan Richard J Infusion pump assembly
US7306578B2 (en) 2002-01-04 2007-12-11 Deka Products Limited Partnership Loading mechanism for infusion pump
EP1390089B1 (en) 2001-05-18 2007-01-24 Deka Products Limited Partnership Infusion set for a fluid pump
WO2002094340A2 (en) 2001-05-22 2002-11-28 Becton, Dickinson And Company Needle shield assembly having hinged needle shield
US7308300B2 (en) 2001-05-30 2007-12-11 Acist Medical Systems, Inc. Medical injection system
US6767341B2 (en) 2001-06-13 2004-07-27 Abbott Laboratories Microneedles for minimally invasive drug delivery
US6565541B2 (en) 2001-07-18 2003-05-20 Inviro Medical Devices Ltd. Cannula guard and cannula for a syringe
AU2002259265B2 (en) 2001-07-27 2008-06-05 Becton, Dickinson And Company Luer connector assembly
DE10163325B4 (de) 2001-07-30 2005-07-28 Tecpharma Licensing Ag Verriegelungssperre für eine Verbindung von Gehäuseabschnitten eines Verabreichungsgeräts
DE10163328B4 (de) 2001-07-30 2005-08-11 Tecpharma Licensing Ag Verabreichungsgerät mit Verdrehsicherung
CH695288A5 (de) 2001-08-21 2006-03-15 Tecpharma Licensing Ag Befestigungsvorrichtung fuer Injektionsnadeln.
US6722916B2 (en) 2001-08-30 2004-04-20 Siemens Vdo Automotive Corporation Surface battery clip
USD471983S1 (en) 2001-09-04 2003-03-18 Hypoguard Limited Blood glucose meter
US8152789B2 (en) 2001-10-23 2012-04-10 Medtronic Minimed, Inc. System and method for providing closed loop infusion formulation delivery
US6827702B2 (en) 2001-09-07 2004-12-07 Medtronic Minimed, Inc. Safety limits for closed-loop infusion pump control
CN100349629C (zh) 2001-09-12 2007-11-21 贝克顿迪肯森公司 用于药物传送的微针为基础的笔装置和使用该装置的方法
US20060122577A1 (en) 2001-09-26 2006-06-08 Poulsen Jens U Modular drug delivery system
US6572565B2 (en) 2001-10-10 2003-06-03 Maxxon, Inc. Blood sampling assembly with a retractable needle
FR2830765B1 (fr) 2001-10-15 2004-07-23 Plastic Omnium Cie Dispositif de securite pour une seringue
US7549977B2 (en) 2002-12-20 2009-06-23 Medrad, Inc. Front load pressure jacket system with syringe holder and light illumination
USD465026S1 (en) 2001-11-13 2002-10-29 Hypoguard Limited Blood glucose meter
US7291126B2 (en) 2001-11-26 2007-11-06 Nilimedix Ltd. Drug delivery device and method
US7311693B2 (en) 2001-11-26 2007-12-25 Nilimedix Ltd. Drug delivery device and method
GB0129171D0 (en) 2001-12-06 2002-01-23 Dca Design Int Ltd Improvements in and relating to a medicament cartridge
US7204823B2 (en) 2001-12-19 2007-04-17 Medtronic Minimed, Inc. Medication delivery system and monitor
US7247149B2 (en) 2001-12-20 2007-07-24 Advanced Cardiovascular Systems, Inc. Contact and penetration depth sensor for a needle assembly
ITTO20011228A1 (it) 2001-12-28 2003-06-28 Cane Srl Contenitore per ago monouso.
JP3763141B2 (ja) 2001-12-28 2006-04-05 ニプロ株式会社 シリンジ型薬液容器
US6786890B2 (en) 2002-01-25 2004-09-07 Novo Nordisk A/S Linear actuator and a medical delivery device comprising such linear actuator
DE60302335T2 (de) 2002-01-25 2006-08-10 Novo Nordisk A/S Linearantrieb und medizinische abgabevorrichtung mit einem solchen linearantrieb
GB0201689D0 (en) 2002-01-25 2002-03-13 Dca Design Consultants Ltd Improvements in and relating to a medicament injection device
JP3993169B2 (ja) 2002-02-11 2007-10-17 アンタレス・ファーマ・インコーポレーテッド 皮内注射器
USD471274S1 (en) 2002-02-23 2003-03-04 Stryker Instruments Medication delivery pump
US7267669B2 (en) 2002-02-23 2007-09-11 Stryker Corporation Two site infusion apparatus
US7033338B2 (en) 2002-02-28 2006-04-25 Smiths Medical Md, Inc. Cartridge and rod for axially loading medication pump
US6744350B2 (en) 2002-02-28 2004-06-01 Smiths Medical Md, Inc. Insulin pump having missed meal bolus alarm
US7041082B2 (en) 2002-02-28 2006-05-09 Smiths Medical Md, Inc. Syringe pump control systems and methods
MXPA04008660A (es) 2002-03-08 2005-06-08 Applied Diabetes Res Inc Montaje de infusion de conexion pivotal, de bajo perfil.
US6805687B2 (en) 2002-03-22 2004-10-19 Codman & Shurtleff, Inc. Infusion pump with access regulator
US7004929B2 (en) 2002-03-29 2006-02-28 Mdc Investment Holdings, Inc. Safety pre-filled cartridge injector
US7052251B2 (en) 2002-04-22 2006-05-30 Medtronic Minimed, Inc. Shape memory alloy wire driven positive displacement micropump with pulsatile output
US6960192B1 (en) 2002-04-23 2005-11-01 Insulet Corporation Transcutaneous fluid delivery system
US6656158B2 (en) 2002-04-23 2003-12-02 Insulet Corporation Dispenser for patient infusion device
US20050238507A1 (en) 2002-04-23 2005-10-27 Insulet Corporation Fluid delivery device
US6656159B2 (en) 2002-04-23 2003-12-02 Insulet Corporation Dispenser for patient infusion device
CA2483935C (en) 2002-05-02 2013-07-02 Pa Knowledge Limited Injection device
US6776777B2 (en) 2002-05-10 2004-08-17 Becton, Dickinson And Company Passive safety shield system for injection devices
US6979316B1 (en) 2002-05-23 2005-12-27 Seedlings Life Science Ventures Llc Apparatus and method for rapid auto-injection of medication
US20050171476A1 (en) 2002-05-24 2005-08-04 Judson Jared A. Medication injecting apparatus with fluid container piston-engaging drive member having internal hollow for accommodating drive member shifting mechanism
US20030236489A1 (en) 2002-06-21 2003-12-25 Baxter International, Inc. Method and apparatus for closed-loop flow control system
GB0214452D0 (en) 2002-06-22 2002-07-31 Liversidge Barry P Medical needle assemblies
US7338465B2 (en) 2002-07-02 2008-03-04 Patton Medical Devices, Lp Infusion device and method thereof
US6752783B2 (en) 2002-07-10 2004-06-22 Ming-Kan Hung Safety device for syringe
US20040010207A1 (en) 2002-07-15 2004-01-15 Flaherty J. Christopher Self-contained, automatic transcutaneous physiologic sensing system
US7250037B2 (en) 2002-07-22 2007-07-31 Becton, Dickinson And Company Patch-like infusion device
ATE347389T1 (de) 2002-07-24 2006-12-15 Deka Products Lp Optischer verschiebungssensor für infusionsgeräte
US7740600B2 (en) 2002-08-02 2010-06-22 Candela Corporation Apparatus and method for inhibiting pain signals transmitted during a skin related medical treatment
US20040049160A1 (en) 2002-09-10 2004-03-11 Chung-Chieh Hsieh Safety hypodermic syringe
BR0314111A (pt) 2002-09-12 2005-07-26 Childrens Hosp Medical Center Método e dispositivo para injeção de medicação sem dor
US7435238B2 (en) 2002-09-13 2008-10-14 Alan Reid Needle device having retractable needle providing enhanced safety
DE10242984B4 (de) 2002-09-17 2010-09-23 Sanatis Gmbh Vorrichtung zum Herstellen von Gemischen aus zwei Komponenten
ATE434455T1 (de) 2002-09-24 2009-07-15 Shl Group Ab Injektionsvorrichtung
US7128727B2 (en) 2002-09-30 2006-10-31 Flaherty J Christopher Components and methods for patient infusion device
US7144384B2 (en) 2002-09-30 2006-12-05 Insulet Corporation Dispenser components and methods for patient infusion device
ATE433775T1 (de) 2002-10-11 2009-07-15 Becton Dickinson Co Insulinabgabesystem mit sensor
US20040082911A1 (en) 2002-10-25 2004-04-29 Bruce Tiu Syringe having needle safely receiving structure
DE10255133B3 (de) * 2002-11-26 2004-04-08 Disetronic Licensing Ag Einführvorrichtung für Nadeleinheiten
US20040116866A1 (en) 2002-12-17 2004-06-17 William Gorman Skin attachment apparatus and method for patient infusion device
WO2004057959A2 (en) 2002-12-20 2004-07-15 Generipharm, Inc. Intracutaneous injection
US6846302B2 (en) 2002-12-31 2005-01-25 Teva Medical Ltd. Needle protector device
US6767336B1 (en) 2003-01-09 2004-07-27 Sheldon Kaplan Automatic injector
AU2004206853A1 (en) 2003-01-16 2004-08-05 Becton, Dickinson And Company Intradermal cellular delivery using narrow gauge micro-cannula
US20090204076A1 (en) 2003-02-03 2009-08-13 Barry Peter Liversidge Medical Injector
US7229419B2 (en) 2003-02-11 2007-06-12 Promex/U.S. Biosy Llc Single-handed biopsy system
US8490790B2 (en) * 2003-02-24 2013-07-23 Becton Dickinson France S.A.S. Plate for holding a group of syringe body objects
US7225694B2 (en) 2003-03-03 2007-06-05 Lockheed Martin Corporation Telescopic actuator
GB0304824D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
GB0304823D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
US7390314B2 (en) 2003-03-05 2008-06-24 Medtronic Minimed, Inc. Lead screw driven reservoir with integral plunger nut and method of using the same
US6997727B1 (en) 2003-03-14 2006-02-14 Zierick Manufacturing Corp Compliant surface mount electrical contacts for circuit boards and method of making and using same
CA2433205A1 (en) 2003-03-18 2004-09-18 James Alexander Keenan Drug delivery, bodily fluid drainage, and biopsy device with enhanced ultrasonic visibility
WO2004093949A1 (en) 2003-04-16 2004-11-04 Allergan, Inc. Controlled volume injection/aspiration device
EP1617754A4 (en) 2003-04-18 2010-01-06 Insulet Corp USER INTERFACE FOR INFUSION PUMP REMOTE CONTROL AND APPLICATION METHOD THEREFOR
EP1624913B1 (en) 2003-05-08 2010-07-21 Novo Nordisk A/S Skin mountable injection device with a detachable needle insertion actuation portion
EP1475113A1 (en) 2003-05-08 2004-11-10 Novo Nordisk A/S External needle inserter
ATE457761T1 (de) * 2003-05-08 2010-03-15 Novo Nordisk As Schwenkbare vorrichtung für eine injektionsnadel
ATE421351T1 (de) 2003-05-29 2009-02-15 It Pharma Llp Spritze mit blockierungsglied
US7500963B2 (en) 2003-07-22 2009-03-10 Safety Syringes, Inc. Systems and methods for automatic medical injection with safeguard
PL1660158T3 (pl) 2003-07-31 2009-07-31 Sid Tech Llc Strzykawka z automatycznie wyzwalaną osłoną zabezpieczającą
US20050027255A1 (en) 2003-07-31 2005-02-03 Sid Technologies, Llc Automatic injector
EP1502616A1 (de) 2003-08-01 2005-02-02 Bünder Glas GmbH Nadelschutz für eine Glasspritze
EP1502613A1 (en) 2003-08-01 2005-02-02 Novo Nordisk A/S Needle device with retraction means
DK2609946T3 (en) 2003-08-12 2018-08-27 Becton Dickinson Co PLASTER-LIKE INFUSION DEVICE WITH PROTECTIVE ELEMENT
PT1656170T (pt) 2003-08-12 2019-05-31 Lilly Co Eli Aparelho para dispensar medicação com parafusos com rosca tripla para vantagem mecânica
CN100509069C (zh) * 2003-08-12 2009-07-08 贝克顿·迪金森公司 片状输液装置
US7097637B2 (en) 2003-08-27 2006-08-29 C. R. Bard, Inc. Safety needle with positive flush
AT7347U1 (de) 2003-08-29 2005-02-25 Pharma Consult Ges M B H & Co Vorrichtung zum automatischen injizieren von injektionsflüssigkeiten
IL157984A (en) 2003-09-17 2015-02-26 Dali Medical Devices Ltd Automatic needle
US7331942B2 (en) * 2003-09-23 2008-02-19 Becton, Dickinson And Company Flush syringe having anti-reflux stopper
US7415525B2 (en) 2003-09-29 2008-08-19 Nokia Corporation USB application adopting bluetooth profile with a sharing implementation
US9033920B2 (en) 2003-10-02 2015-05-19 Medtronic, Inc. Determining catheter status
KR20060099520A (ko) 2003-10-21 2006-09-19 노보 노르디스크 에이/에스 의료용 피부 장착 장치
EP1696981B1 (en) 2003-10-21 2009-10-21 Novo Nordisk A/S Internal fluid connector for establishing a fluid connection
DK2664550T3 (da) * 2003-10-30 2019-11-11 Simplivia Healthcare Ltd Indretning til sikker håndtering af lægemiddel
US7717913B2 (en) 2003-11-06 2010-05-18 Misonix, Incorporated RF cauterization and ultrasonic ablation instrument with multi-hole collar and electrode mounting sleeve
US7850658B2 (en) 2003-11-10 2010-12-14 Smiths Medical Asd, Inc. Subcutaneous infusion device and method including release feature for adhesive portion
FR2876035B1 (fr) 2003-11-14 2007-03-30 Plastic Omnium Cie Ensemble de securite destine a equiper une seringue et ensemble de seringue
US7004104B1 (en) 2003-12-15 2006-02-28 Jerome Kundus Adjustable golf flagstick
CH696421A5 (de) 2003-12-18 2007-06-15 Tecpharma Licensing Ag Autoinjektor mit Arretierung des Wirkstoffbehälters.
US20050177136A1 (en) 2003-12-19 2005-08-11 Miller Landon C. Externally disposed pump for use with an internally mounted and compliant catheter
US20050154353A1 (en) * 2004-01-09 2005-07-14 Alheidt Thomas A. Positive displacement flush syringe
ES2764664T3 (es) 2004-01-09 2020-06-04 Becton Dickinson Co Jeringuilla de enjuague con desplazamiento positivo
US20050159706A1 (en) 2004-01-20 2005-07-21 Becton, Dickinson And Company Medical syringe with safety shield system
WO2005072795A2 (en) 2004-01-29 2005-08-11 M 2 Medical A/S Disposable medicine dispensing device
PL1715904T3 (pl) 2004-02-18 2016-01-29 Ares Trading Sa Ręczne, sterowane elektroniczne urządzenie iniekcyjne do wstrzykiwania ciekłych leków
JP4549079B2 (ja) 2004-03-05 2010-09-22 パナソニック株式会社 医療用投与器具
CN2689323Y (zh) 2004-03-11 2005-03-30 鸿富锦精密工业（深圳）有限公司 主板固定装置
US7565208B2 (en) 2004-03-25 2009-07-21 Boston Scientific Scimed, Inc. Catheter with sensor tips, tool and device and methods of use of same
US7699829B2 (en) 2004-03-25 2010-04-20 Boston Scientific Scimed, Inc. Catheter with sensor tip and method of use of same
US7585287B2 (en) 2004-06-16 2009-09-08 Smiths Medical Md, Inc. Device and method for insertion of a cannula of an infusion device
US7588559B2 (en) 2004-07-01 2009-09-15 W&H Dentalwerk Bürmoos GmbH Injection systems
US7255684B2 (en) 2004-08-09 2007-08-14 Boris Zubry Medical injection system
GB0418256D0 (en) 2004-08-16 2004-09-15 The Technology Partnership Plc Liquid dispensing device
US20080215006A1 (en) 2004-09-22 2008-09-04 Novo Nordisk A/S Medical Device with Transcutaneous Cannula Device
EP1640029A1 (en) 2004-09-24 2006-03-29 Novo Nordisk A/S Injection device with cap
CA2582976C (en) 2004-10-04 2013-10-29 Sanofi-Aventis Deutschland Gmbh Drive mechanism for a drug delivery device
WO2006045523A1 (en) 2004-10-21 2006-05-04 Novo Nordisk A/S Medication delivery system with a detector for providing a signal indicative of an amount of an ejected dose of drug
WO2006045525A1 (en) 2004-10-21 2006-05-04 Novo Nordisk A/S Injection device with a processor for collecting ejection information
US7255689B2 (en) 2004-10-29 2007-08-14 Safety Syringes, Inc. Syringe with anti-rotation for luer lock
WO2006052737A1 (en) 2004-11-04 2006-05-18 Sid Technologies, Llc Automatic injector
WO2006057604A1 (en) 2004-11-24 2006-06-01 Shl Medical Ab Injection device
JP2006142369A (ja) 2004-11-24 2006-06-08 Ykk Corp 電動式射出ユニット及び同ユニットを備えたダイキャストマシンと電動式射出方法
USD544092S1 (en) 2004-12-03 2007-06-05 Kci Licensing, Inc. Wearable negative pressure wound care appliance
US7303543B1 (en) 2004-12-03 2007-12-04 Medtronic Minimed, Inc. Medication infusion set
CN101484198A (zh) 2004-12-09 2009-07-15 韦斯特制药服务公司 尾部装有固定针的注射器和具有该注射器的自动注射装置
US7418880B1 (en) 2004-12-13 2008-09-02 Michael P Smith Sample collector using a syringe with a side port in the barrel
US20090043245A1 (en) 2004-12-22 2009-02-12 Li Nguyen Device for administering an injection and method of using same
CN102895735B (zh) 2004-12-27 2015-12-16 皇家飞利浦电子股份有限公司 预置自动外部除纤颤器以便使用的方法
US9636450B2 (en) 2007-02-19 2017-05-02 Udo Hoss Pump system modular components for delivering medication and analyte sensing at seperate insertion sites
DE102004063664A1 (de) 2004-12-31 2006-07-20 Tecpharma Licensing Ag Echtzeitanzeige für eine Vorrichtung zur dosierten Verabreichung eines Produkts
US20060173439A1 (en) 2005-01-18 2006-08-03 Thorne Gale H Jr Syringe drive system
CN101107028B (zh) 2005-01-24 2013-04-10 诺和诺德公司 经皮设备组件
US7547281B2 (en) 2005-02-01 2009-06-16 Medtronic Minimed, Inc. Algorithm sensor augmented bolus estimator for semi-closed loop infusion system
GB2440039A (en) 2005-02-01 2008-01-16 Intelliject Llc Devices, systems and methods for medicament delivery
US9022980B2 (en) 2005-02-01 2015-05-05 Kaleo, Inc. Medical injector simulation device
US7731686B2 (en) 2005-02-01 2010-06-08 Intelliject, Inc. Devices, systems and methods for medicament delivery
US8231573B2 (en) 2005-02-01 2012-07-31 Intelliject, Inc. Medicament delivery device having an electronic circuit system
US7704229B2 (en) 2005-02-03 2010-04-27 Medtronic Minimed, Inc. Insertion device
ATE414551T1 (de) 2005-02-21 2008-12-15 Novo Nordisk As Verfahren zur sicherstellung von konstanter motorgeschwindigkeit bei einer injektionsvorrichtung
JP2008531093A (ja) 2005-02-23 2008-08-14 ノボ・ノルデイスク・エー／エス ピストンロッドを注入器具の中で反転させる方法及び装置
WO2006102412A2 (en) 2005-03-21 2006-09-28 Abbott Diabetes Care, Inc. Method and system for providing integrated medication infusion and analyte monitoring system
WO2006102676A1 (en) 2005-03-23 2006-09-28 Tissue Engineering Refraction, Inc. Injectable polyethylene oxide dermal fillers and related devices
ATE413895T1 (de) 2005-03-24 2008-11-15 Disetronic Licensing Ag Vorrichtung für die dosierte verabreichung eines fluiden produkts
CA2597024A1 (en) 2005-03-28 2006-10-05 Insulet Corporation Fluid delivery device
JP2008534131A (ja) 2005-03-28 2008-08-28 インシュレット コーポレイション 流体投与装置
WO2006105793A1 (en) 2005-04-06 2006-10-12 M 2 Medical A/S Method and device for dispensing liquid medicine by means of a twistable element
EP1893259B1 (en) 2005-04-20 2018-04-18 Becton Dickinson France Injection set and injection assistance device
US8277415B2 (en) 2006-08-23 2012-10-02 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US7905868B2 (en) 2006-08-23 2011-03-15 Medtronic Minimed, Inc. Infusion medium delivery device and method with drive device for driving plunger in reservoir
US7569050B2 (en) 2005-05-06 2009-08-04 Medtronic Minimed, Inc. Infusion device and method with drive device in infusion device and method with drive device in separable durable housing portion
CN101175516B (zh) 2005-05-13 2011-02-16 诺和诺德公司 适于检测经皮装置脱离的医疗装置
US8021357B2 (en) 2005-05-27 2011-09-20 Olympus Corporation Body-insertable apparatus
DE102005025639B4 (de) 2005-06-03 2011-04-07 Innovacell Biotechnologie Gmbh Injektionsvorrichtung
US20060283465A1 (en) 2005-06-16 2006-12-21 Nickel Janice H Smart drug delivery system and a method of implementation thereof
WO2007002053A2 (en) 2005-06-21 2007-01-04 Eli Lilly And Company Needled pharmaceutical delivery device with triggered automatic needle insertion and manually controlled pharmaceutical injection
PL1909870T5 (pl) 2005-07-27 2016-10-31 Novo Nordisk As Mechanizm dozujący dla przyrządu wstrzykującego do ograniczania nastawionej dawki odpowiadającej ilości pozostającego lekarstwa
US20070025879A1 (en) 2005-07-27 2007-02-01 Dakocytomation Denmark A/S Method and apparatus for syringe-based sample introduction within a flow cytometer
US7713240B2 (en) 2005-09-13 2010-05-11 Medtronic Minimed, Inc. Modular external infusion device
EP2162168B1 (en) 2005-09-26 2018-11-07 Bigfoot Biomedical, Inc. Modular infusion pump having two different energy sources
US8105279B2 (en) 2005-09-26 2012-01-31 M2 Group Holdings, Inc. Dispensing fluid from an infusion pump system
US7534226B2 (en) 2005-09-26 2009-05-19 M2 Group Holdings, Inc. Dispensing fluid from an infusion pump system
US8409142B2 (en) 2005-09-26 2013-04-02 Asante Solutions, Inc. Operating an infusion pump system
US8057436B2 (en) 2005-09-26 2011-11-15 Asante Solutions, Inc. Dispensing fluid from an infusion pump system
US8551046B2 (en) 2006-09-18 2013-10-08 Asante Solutions, Inc. Dispensing fluid from an infusion pump system
US8469984B2 (en) 2005-10-25 2013-06-25 Bayer Healthcare Llc Single use lancing device
DK2926847T3 (da) 2005-11-02 2022-07-04 Medicaltree Patents Ltd Implanterbar infusionsapparat med fremførbar og tilbagetrækkelig nål
US7935104B2 (en) 2005-11-07 2011-05-03 Medingo, Ltd. Systems and methods for sustained medical infusion and devices related thereto
WO2007056504A1 (en) 2005-11-08 2007-05-18 M2 Medical A/S Infusion pump system
GB2433032A (en) 2005-12-08 2007-06-13 Owen Mumford Ltd Syringe with dose adjustment means
JP4358821B2 (ja) 2005-12-15 2009-11-04 オリンパス株式会社 被検体内導入装置
US7988660B2 (en) 2005-12-20 2011-08-02 Eli Lilly And Company Needle-free injection device
WO2007073228A1 (en) 2005-12-20 2007-06-28 Siemens Aktiengesellschaft Backplane for a programmable logic controller
PL1962926T3 (pl) 2005-12-23 2009-10-30 Unomedical As Urządzenie wstrzykujące
US7510543B2 (en) * 2005-12-28 2009-03-31 Smiths Medical Md, Inc. Removable sharps device for accessing a portal reservoir
GB0600351D0 (en) 2006-01-10 2006-02-15 Weston Terence E Safe hypodermic needle
WO2007119178A2 (en) 2006-01-23 2007-10-25 Neuren Pharmaceuticals Limited Infusion pump
EP2520324A2 (en) 2006-02-09 2012-11-07 Aderans Research Institute, Inc. Micrometer assisted fluid delivery device
USD578210S1 (en) 2006-03-14 2008-10-07 Hisamitsu Pharmaceutical Co., Inc. Injector
US20070299400A1 (en) 2006-03-16 2007-12-27 Seattle Medical Technologies Infusion device with dome pump
DE102006013322A1 (de) 2006-03-21 2007-09-27 Sarstedt Ag & Co. Kanüle mit einem Schutzgehäuse
GB2436526B (en) * 2006-03-29 2010-01-27 Arash Bakhtyari-Nejad-Esfahani Syringe
US9392969B2 (en) 2008-08-31 2016-07-19 Abbott Diabetes Care Inc. Closed loop control and signal attenuation detection
AT502791B1 (de) 2006-04-06 2007-05-15 Pharma Consult Ges M B H & Co Injektionsspritze
JP4982722B2 (ja) 2006-04-19 2012-07-25 ノボ・ノルデイスク・エー／エス 流体注入システム、同システムの組み立て方法、及び同システムに使用される薬剤容器
EP2010256A1 (en) 2006-04-19 2009-01-07 Novo Nordisk A/S A fluid infusion system, a method of assembling such system and drug reservoir for use in the system
TWI298216B (en) 2006-04-21 2008-06-21 Hon Hai Prec Ind Co Ltd Power supply devices and electronic products using the same
US7589974B2 (en) 2006-04-21 2009-09-15 Helwett-Packard Development Company, L.P. Modular server and method
FR2900749B1 (fr) 2006-05-05 2008-07-25 Thales Sa Procede et dispositif de securisation de la memoire d'un calculateur a l'encontre des erreurs dues aux radiations
JP4833731B2 (ja) 2006-05-16 2011-12-07 テルモ株式会社 シリンジポンプ
RU2433840C2 (ru) 2006-05-18 2011-11-20 Ново Нордиск А/С Инъецирующее устройство со средством блокирования функции
US20070282269A1 (en) 2006-05-31 2007-12-06 Seattle Medical Technologies Cannula delivery apparatus and method for a disposable infusion device
EP2035065B1 (en) 2006-06-28 2014-06-18 Perf-Action Technologies Ltd. Intradermal needle-less injection device
JP5535623B2 (ja) 2006-06-30 2014-07-02 アッヴィ バイオテクノロジー リミテッド 自動注射装置
US7666165B2 (en) 2006-07-06 2010-02-23 Warsaw Orthopedic, Inc. Cannulated sensing device
JP4738275B2 (ja) 2006-07-07 2011-08-03 日本航空電子工業株式会社 ランプ管用コネクタ
US8382718B2 (en) 2006-07-31 2013-02-26 B. Braun Melsungen Ag Needle assembly and components thereof
US7740792B2 (en) 2006-08-03 2010-06-22 Medrad, Inc. Methods of molding a syringe
GB0615589D0 (en) 2006-08-04 2006-09-13 Salvus Technology Ltd Safety needle accessory
US8206296B2 (en) 2006-08-07 2012-06-26 Abbott Diabetes Care Inc. Method and system for providing integrated analyte monitoring and infusion system therapy management
US7682338B2 (en) 2006-08-23 2010-03-23 Medtronic Minimed, Inc. Infusion medium delivery system, device and method with needle inserter and needle inserter device and method
ATE493162T1 (de) 2006-08-28 2011-01-15 Novo Nordisk As Axial verschliessbares und durch drehung zu öffnendes medikamentenverabreichungssystem
AU2007289584A1 (en) 2006-08-28 2008-03-06 Teijin Limited Polycarbonate resin composition comprising plant-derived component
CN100596233C (zh) 2006-08-31 2010-03-24 华为技术有限公司 移动通信切换方法及其系统和基站
US20080097387A1 (en) * 2006-09-04 2008-04-24 Spector David M Oral cavity liquid delivery system including pre-angled needle assembly and method for using the same
US8162923B2 (en) 2006-09-06 2012-04-24 Calibra Medical, Inc. Disposable infusion device with automatic unlocking mechanism
FR2905273B1 (fr) 2006-09-06 2009-04-03 Becton Dickinson France Soc Pa Dispositif d'injection automatique avec moyen de temporisation.
DE102006049528A1 (de) 2006-09-28 2008-04-03 Robert Bosch Gmbh Vorrichtung und Verfahren zur Montage eines Nadelschutzes auf einen Spritzenkörper
WO2008043724A2 (en) 2006-10-12 2008-04-17 Dynamic Therapeutics Ltd Regulated drug delivery system
US8974410B2 (en) * 2006-10-30 2015-03-10 Vidacare LLC Apparatus and methods to communicate fluids and/or support intraosseous devices
WO2008057976A2 (en) 2006-11-03 2008-05-15 Avanca Medical Devices, Inc. Multiple dose syringes
US7780637B2 (en) 2006-11-06 2010-08-24 Steven Jerde Medical device container
GB2443606B (en) 2006-11-13 2011-07-20 Cilag Gmbh Int Injection device
EP1923083A1 (en) 2006-11-17 2008-05-21 Sanofi-Aventis Deutschland GmbH Drive mechanisms for use in drug delivery devices
US7704227B2 (en) 2006-11-29 2010-04-27 Medtronic Minimed, Inc. Methods and apparatuses for detecting medical device acceleration, temperature, and humidity conditions
US8282599B2 (en) 2006-12-08 2012-10-09 Boston Scientific Scimed, Inc. Therapeutic catheter with displacement sensing transducer
WO2008072229A2 (en) 2006-12-12 2008-06-19 Nanopass Technologies Ltd. Methods for dermal filling using microneedles
ES2365931T3 (es) 2006-12-13 2011-10-13 Shl Group Ab Inyector automático.
US8057431B2 (en) 2006-12-21 2011-11-15 B. Braun Melsungen Ag Hinged cap for needle device
PT3632488T (pt) 2006-12-22 2023-06-21 Hoffmann La Roche Dispositivo para administração sustentada de um fluido terapêutico
US7488181B2 (en) 2007-01-09 2009-02-10 Laird Technologies, Inc. Electrocoated contacts compatible with surface mount technology
US9283177B2 (en) 2007-01-16 2016-03-15 Juventio, Llc Topical anesthetic for rapid local anesthesia and method of applying a topical anesthetic
US7540858B2 (en) 2007-01-23 2009-06-02 Becton, Dickinson And Company Retracting safety pen needle
US8038654B2 (en) 2007-02-26 2011-10-18 Becton, Dickinson And Company Syringe having a hinged needle shield
FR2913202A1 (fr) 2007-03-02 2008-09-05 Becton Dickinson France Soc Pa Protection pour couvrir l'extremite d'un dispositif d'administration ou d'un sous-ensemble,sous-ensemble et dispositif d'administration
ATE477011T1 (de) 2007-03-14 2010-08-15 Hoffmann La Roche Insertionsvorrichtung für einen insertionskopf, insbesondere für ein infusionsset
DE102007013838A1 (de) 2007-03-22 2008-09-25 Tecpharma Licensing Ag Injektionsvorrichtung mit zeitkonstantem Ausschüttsignal
CN101641126B (zh) 2007-03-23 2014-06-04 诺沃-诺迪斯克有限公司 包括锁定螺母的注射装置
EP1974759A1 (de) 2007-03-29 2008-10-01 Jürgen Schmidt-Evers Injektionsgerät, insbesondere Insulin-Pen
US8034019B2 (en) 2007-04-10 2011-10-11 Amrita Vishwa Vidyapeetham Dual microcontroller-based liquid infusion system
US7501587B2 (en) 2007-04-16 2009-03-10 Laird Technologies, Inc. Mounting clips for use with electromagnetic interference shielding and methods of using the same
EP2139543B1 (en) 2007-04-23 2018-06-06 Sid Technologies LLC Devices for intradermal injection
US20080269723A1 (en) 2007-04-25 2008-10-30 Medtronic Minimed, Inc. Closed loop/semi-closed loop therapy modification system
JP4867775B2 (ja) * 2007-04-26 2012-02-01 株式会社ジェイ・エム・エス 注射器ホルダ及び注射器装置
FI7960U1 (fi) 2007-04-27 2008-07-28 Bayer Schering Pharma Oy Implantoitavan annostelusysteemin membraanikuori
US7963954B2 (en) 2007-04-30 2011-06-21 Medtronic Minimed, Inc. Automated filling systems and methods
CA2685474C (en) 2007-04-30 2014-07-08 Medtronic Minimed, Inc. Reservoir filling, bubble management, and infusion medium delivery systems and methods with same
US8323250B2 (en) 2007-04-30 2012-12-04 Medtronic Minimed, Inc. Adhesive patch systems and methods
CN101682528B (zh) 2007-05-02 2014-05-14 西纳普斯无线股份有限公司 在传感器网络中动态地配置节点行为的系统和方法
WO2008135098A1 (en) 2007-05-07 2008-11-13 Unomedical A/S Cannula and delivery device
JP5536641B2 (ja) * 2007-05-11 2014-07-02 エフ．ホフマン−ラ ロシュ アーゲー 能動変位ポンプ
US7794426B2 (en) 2007-05-21 2010-09-14 Asante Solutions, Inc. Infusion pump system with contamination-resistant features
CA125684S (en) 2007-05-31 2008-06-26 Danfoss Bionics As Insulin pump
US8157693B2 (en) 2007-06-19 2012-04-17 American Axle & Manufacturing, Inc. Helical differential assembly with preloaded adjustment mechanism
US8002752B2 (en) 2007-06-25 2011-08-23 Medingo, Ltd. Protector apparatus
DK2173407T3 (da) 2007-07-02 2020-04-27 Hoffmann La Roche Anordning til indgivelse af lægemiddel
AU2008278640A1 (en) 2007-07-20 2009-01-29 F.Hoffmann-La Roche Ag Manually operable portable infusion device
WO2009016635A2 (en) 2007-08-01 2009-02-05 Medingo Ltd. Detachable portable infusion device
GB2451666B (en) 2007-08-08 2012-08-22 Cilag Gmbh Int Injection device
GB2452030A (en) 2007-08-10 2009-02-25 Owen Mumford Ltd Injection devices
US7828528B2 (en) 2007-09-06 2010-11-09 Asante Solutions, Inc. Occlusion sensing system for infusion pumps
US7717903B2 (en) 2007-09-06 2010-05-18 M2 Group Holdings, Inc. Operating an infusion pump system
US7879026B2 (en) 2007-09-07 2011-02-01 Asante Solutions, Inc. Controlled adjustment of medicine dispensation from an infusion pump device
US7935105B2 (en) 2007-09-07 2011-05-03 Asante Solutions, Inc. Data storage for an infusion pump system
CN101868270B (zh) 2007-09-25 2013-10-16 贝克顿迪金森法国公司 具有包括动用痕迹显示装置的去防护器的自动注射器
EP2873431B1 (en) * 2007-09-25 2017-07-19 Becton Dickinson France Method for removing a deshielder from a device for automatic injection
US8469923B2 (en) 2007-09-27 2013-06-25 Becton, Dickinson And Company Cartridge for powder and liquid drug
US7771391B2 (en) 2007-09-28 2010-08-10 Calibra Medical, Inc. Disposable infusion device with snap action actuation
US8128596B2 (en) 2007-09-28 2012-03-06 Calibra Medial, Inc. Disposable infusion device layered structure
DK2192935T3 (da) 2007-10-01 2020-05-04 Hoffmann La Roche Patronadapter til brug i et infusionssystem
US9656019B2 (en) 2007-10-02 2017-05-23 Medimop Medical Projects Ltd. Apparatuses for securing components of a drug delivery system during transport and methods of using same
US9345836B2 (en) 2007-10-02 2016-05-24 Medimop Medical Projects Ltd. Disengagement resistant telescoping assembly and unidirectional method of assembly for such
JP5653217B2 (ja) 2007-10-02 2015-01-14 メディモップ メディカル プロジェクツ、エル・ティー・ディー 外部薬剤ポンプ
US10420880B2 (en) 2007-10-02 2019-09-24 West Pharma. Services IL, Ltd. Key for securing components of a drug delivery system during assembly and/or transport and methods of using same
US7967795B1 (en) 2010-01-19 2011-06-28 Lamodel Ltd. Cartridge interface assembly with driving plunger
EP2195048B1 (en) 2007-10-11 2018-12-12 Roche Diabetes Care GmbH Carrier for an infusion system
FR2922112B1 (fr) 2007-10-11 2009-12-04 Rexam Pharma La Verpilliere Dispositif de securite pour une seringue d'injection de liquide et ensemble a seringue comprenant ce dispositif
DE102007049446A1 (de) 2007-10-16 2009-04-23 Cequr Aps Katheter-Einführeinrichtung
US7922695B2 (en) 2007-10-18 2011-04-12 Roche Diagnostics Operations, Inc. Drug delivery pump drive using linear piezoelectric motor
EP2052677A1 (en) 2007-10-23 2009-04-29 Sensile Pat AG Medical device for glucose monitoring or regulation
JP5215632B2 (ja) 2007-10-25 2013-06-19 テルモ株式会社 コネクタのプライミング方法
ES2688900T3 (es) 2007-11-12 2018-11-07 Medicom Innovation Partner A/S Autoinyector con ubicaciones de anclaje cambiantes para un accionador mecánico
US8308695B2 (en) 2007-11-14 2012-11-13 Shl Group Ab Automatic injection device with actively triggered syringe withdrawal
JP2009119171A (ja) 2007-11-19 2009-06-04 Daikyo Seiko Ltd プランジャロッドおよび注射器
GB2446247B (en) 2007-11-27 2008-12-17 Robert Joseph Wagener Homeostatic insulin pump
WO2009069064A1 (en) 2007-11-27 2009-06-04 Koninklijke Philips Electronics N.V. Implantable therapeutic substance delivery device
US7918825B2 (en) 2007-11-29 2011-04-05 Insulet Corporation Interfacing a prefilled syringe with an infusion pump to fill the infusion pump
US7771392B2 (en) 2007-11-29 2010-08-10 Roche Diagnostics Operations, Inc. Lead screw delivery device using reusable shape memory actuator drive
US7806868B2 (en) 2007-11-30 2010-10-05 Roche Diagnostics Operations, Inc. Drug reservoir loading and unloading mechanism for a drug delivery device using a unidirectional rotated shaft
US20090149830A1 (en) 2007-12-07 2009-06-11 Donald Spector Intelligent needle technology for acupuncture and injection of cosmetic preparations subcutaneously
CN101461976A (zh) * 2007-12-21 2009-06-24 关和瑜 一种笔式胰岛素注射器常规胰岛素专用笔芯
WO2009081404A1 (en) 2007-12-26 2009-07-02 Medingo Ltd. System and method for glycemic control
US8313467B2 (en) 2007-12-27 2012-11-20 Medtronic Minimed, Inc. Reservoir pressure equalization systems and methods
BRPI0821876B8 (pt) * 2008-01-11 2021-06-22 Ucb Pharma Sa tampa de ponta e seringa
US8721603B2 (en) 2008-01-15 2014-05-13 West Pharmaceutical Services, Inc. Syringe with co-molded hub and cannula
US8496862B2 (en) 2008-01-15 2013-07-30 West Pharmaceutical Services, Inc. Collet mechanism and method of molding cannula to a syringe barrel
US8708961B2 (en) 2008-01-28 2014-04-29 Medsolve Technologies, Inc. Apparatus for infusing liquid to a body
USD604835S1 (en) 2008-02-01 2009-11-24 Conley N Sharon Patient controlled timed medication dispenser
GB0802351D0 (en) 2008-02-08 2008-03-12 Owen Mumford Ltd Injection devices
US20090209896A1 (en) 2008-02-19 2009-08-20 Selevan James R Method and apparatus for time-dependent and temperature-dependent clinical alert
US9446185B2 (en) 2008-03-12 2016-09-20 Roche Diabetes Care, Inc. Devices and methods for improving accuracy of fluid delivery
US8540673B2 (en) 2008-03-18 2013-09-24 Calibra Medical, Inc. Disposable infusion device with actuation lock-out
EP2260462B1 (en) 2008-04-04 2018-12-19 Hygieia, Inc. System for optimizing a patient's insulin dosage regimen
EP3260145B1 (en) 2008-04-09 2019-12-11 Roche Diabetes Care GmbH Fluid level sensor for a modular skin-adherable system for medical fluid delivery
US20090259176A1 (en) 2008-04-09 2009-10-15 Los Gatos Research, Inc. Transdermal patch system
US8801679B2 (en) 2008-04-10 2014-08-12 Panasonic Healthcare Co., Ltd. Medication administering device
US8287520B2 (en) 2008-04-10 2012-10-16 Medtronic, Inc. Automated integrity tests
EP2279021B1 (en) 2008-04-18 2013-02-13 Kuros Biosurgery AG Dispensing device, kit containing the device, and method of operating the device
JP5227645B2 (ja) 2008-04-21 2013-07-03 矢崎総業株式会社 基板用コネクタ
DK2276524T3 (da) 2008-05-07 2012-04-23 Hoffmann La Roche Visning i forbindelse med et administrationsanlæg til infusion
US8177749B2 (en) 2008-05-20 2012-05-15 Avant Medical Corp. Cassette for a hidden injection needle
MX2010012691A (es) 2008-05-20 2011-03-30 Avant Medical Corp Star Sistema auto-inyector.
EP2140897B1 (en) 2008-06-30 2011-05-25 Animas Corporation Drive mechanism
US20090326509A1 (en) 2008-06-30 2009-12-31 Muse Philip A Context aware medical monitoring and dosage delivery device
US20110160669A1 (en) 2008-07-07 2011-06-30 Steffen Gyrn Inserter for Transcutaneous Device
US8706863B2 (en) 2008-07-18 2014-04-22 Apple Inc. Systems and methods for monitoring data and bandwidth usage
DE102008033887B4 (de) 2008-07-18 2012-02-09 weiss Präzisionstechnik GmbH & Co. KG Teleskop-Doppelspindelantrieb
USD602586S1 (en) 2008-07-23 2009-10-20 Animas Corporation Drug delivery pod
USD602155S1 (en) 2008-07-28 2009-10-13 Animas Corporation Drug delivery pod
US8795259B2 (en) 2008-08-01 2014-08-05 Wisconsin Alumni Research Foundation Drug delivery platform incorporating hydrogel pumping mechanism with guided fluid flow
US8986250B2 (en) 2008-08-01 2015-03-24 Wisconsin Alumni Research Foundation Drug delivery platform utilizing hydrogel pumping mechanism
KR101013581B1 (ko) 2008-08-06 2011-02-14 라종주 전기 피부 미용기
DE102008037310B4 (de) 2008-08-11 2023-11-16 Ypsomed Ag Automatische Injektionsvorrichtung für die Verabreichung einer festen Dosis
GB0814747D0 (en) 2008-08-13 2008-09-17 Owen Mumford Ltd Autoinjection devices
US8029526B2 (en) 2008-08-14 2011-10-04 Abbott Diabetes Care Inc. Cocking mechanism for lancing device
US20100049128A1 (en) 2008-08-18 2010-02-25 Calibra Medical, Inc. Drug infusion system with reusable and disposable components
GB0815897D0 (en) 2008-09-01 2008-10-08 Benmore Ventures Ltd Container illumination device
WO2010029551A2 (en) 2008-09-11 2010-03-18 Medingo Ltd. Methods and devices for tailoring a bolus delivery pattern
US9427529B2 (en) * 2008-09-15 2016-08-30 Medimop Medical Projects Ltd. Safeguard mechanism for autoinjector needle
US9393369B2 (en) 2008-09-15 2016-07-19 Medimop Medical Projects Ltd. Stabilized pen injector
US8876778B2 (en) 2008-09-29 2014-11-04 Becton Dickinson France Injection device with retaining means actuated by needle shield
US8366668B2 (en) 2008-09-29 2013-02-05 Becton Dickinson France Autoinjector with audible indication of completed delivery
US20100145305A1 (en) 2008-11-10 2010-06-10 Ruth Alon Low volume accurate injector
EP2355875A4 (en) 2008-11-18 2014-04-30 Braun Melsungen Ag PROTECTIVE COVER FOR INJECTION SYRINGE
EP2198904A1 (en) 2008-12-19 2010-06-23 Sanofi-Aventis Deutschland GmbH Interlock mechanism for a drug delivery device and drug delivery device
EP2201968A1 (de) 2008-12-24 2010-06-30 Roche Diagnostics GmbH Insertionssystem und Insertionsvorrichtung
US8152779B2 (en) * 2008-12-30 2012-04-10 Medimop Medical Projects Ltd. Needle assembly for drug pump
DK2391408T3 (en) 2008-12-31 2018-02-05 Hoffmann La Roche PORTABLE MEDICAL FLUID ADMINISTRATION WITH DRIVE SCREW LED CONNECTOR WITH CONTAINER STAMP
KR102005930B1 (ko) 2008-12-31 2019-07-31 레반스 테라퓨틱스, 아이엔씨. 주사용 보툴리눔 독소 제제
US8790295B1 (en) 2009-01-05 2014-07-29 Medtronic, Inc. Pressure monitoring to control delivery of therapeutic agent
KR20100086881A (ko) 2009-01-23 2010-08-02 삼성전자주식회사 백라이트 어셈블리 및 이를 포함하는 표시 장치
US8221352B2 (en) 2009-01-29 2012-07-17 Michael Merchant Disposable safety needle system and safety enclosure means
AU2010210163B2 (en) 2009-02-05 2014-09-11 Sanofi-Aventis Deutschland Gmbh Medicament delivery devices
CA2750465A1 (en) 2009-02-05 2010-08-12 Sanofi-Aventis Deutschland Gmbh Medicament delivery devices
NZ594318A (en) 2009-02-05 2012-12-21 Sanofi Aventis Deutschland Medicament delivery devices with a telescopic piston rod assembly
CA2757134A1 (en) 2009-03-31 2010-10-07 Sanofi-Aventis Deutschland Gmbh Improvements in and relating to medicament delivery devices
EP2241344B1 (en) 2009-04-16 2013-12-11 F. Hoffmann-La Roche AG Ambulatory infusion device with sensor testing unit
JP5698223B2 (ja) * 2009-05-20 2015-04-08 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 薬物送達デバイスにおける薬物含有カートリッジ用の栓
CN102481415B (zh) 2009-07-08 2014-03-05 诺沃—诺迪斯克有限公司 防冻注射设备
BR112012000795A2 (pt) 2009-07-15 2016-02-23 Sanofi Aventis Deutschland mecanismo de acionamento para um dispositivo de injeção e um dispositivo de injeção com o referido mecanismo de acionamento
JP5180379B2 (ja) 2009-07-23 2013-04-10 パナソニック株式会社 シリンジ駆動装置及び調剤装置
EP2735376B1 (en) * 2009-07-24 2017-08-23 Bayer Healthcare LLC Syringe for a fluid injector system
KR101712226B1 (ko) 2009-07-31 2017-03-03 쓰리엠 이노베이티브 프로퍼티즈 컴파니 중공형 미세침 어레이
ES2407662T3 (es) 2009-08-07 2013-06-13 Becton Dickinson France Bandeja para colocar objetos alargados, en particular cuerpos de jeringa o jeringas
US8900190B2 (en) 2009-09-02 2014-12-02 Medtronic Minimed, Inc. Insertion device systems and methods
US8308679B2 (en) 2009-12-30 2012-11-13 Medtronic Minimed, Inc. Alignment systems and methods
US8157769B2 (en) 2009-09-15 2012-04-17 Medimop Medical Projects Ltd. Cartridge insertion assembly for drug delivery system
US10071196B2 (en) 2012-05-15 2018-09-11 West Pharma. Services IL, Ltd. Method for selectively powering a battery-operated drug-delivery device and device therefor
CA2772494A1 (en) 2009-09-18 2011-03-24 Sanofi-Aventis Deutschland Gmbh Arrangement for determining a longitudinal position of a stopper
CN102665801B (zh) 2009-10-08 2015-06-17 Shl集团有限责任公司 药物输送装置
ES2680668T3 (es) 2009-10-16 2018-09-10 Janssen Biotech, Inc. Dispositivo de administración de fármacos activado con la palma de la mano
JP2011136151A (ja) * 2009-10-19 2011-07-14 Terumo Medical Corp 着脱可能な注射針組立体及び低デッドスペースを有している注射器組立体
EP3000498B1 (en) 2009-10-21 2018-04-11 Owen Mumford Limited Autoinjector
JP5408541B2 (ja) 2009-11-06 2014-02-05 北川工業株式会社 表面実装クリップ
US8241240B2 (en) 2009-11-09 2012-08-14 Medtronic Xomed, Inc. Adjustable valve setting with motor control
DK2327433T3 (da) 2009-11-26 2012-07-23 Hoffmann La Roche Udefra udløselig kanyleanordning
EP2512580A4 (en) 2009-12-16 2013-06-12 Becton Dickinson Co SELF-INJECTION DEVICE
US8795260B2 (en) 2009-12-18 2014-08-05 Medtronic, Inc. Refill of implantable fluid delivery devices based on therapeutic fluid expiration
US8858500B2 (en) 2009-12-30 2014-10-14 Medtronic Minimed, Inc. Engagement and sensing systems and methods
US8435209B2 (en) 2009-12-30 2013-05-07 Medtronic Minimed, Inc. Connection and alignment detection systems and methods
US20110172645A1 (en) 2010-01-08 2011-07-14 Ratio, Inc. Wearable drug delivery device including integrated pumping and activation elements
US8348898B2 (en) 2010-01-19 2013-01-08 Medimop Medical Projects Ltd. Automatic needle for drug pump
US9295778B2 (en) 2011-12-21 2016-03-29 Deka Products Limited Partnership Syringe pump
US9789247B2 (en) 2011-12-21 2017-10-17 Deka Products Limited Partnership Syringe pump, and related method and system
EP2525851B1 (en) 2010-01-22 2019-05-08 Sanofi-Aventis Deutschland GmbH Coded cartridge holder and fastener enabled by cartridge size
USD650079S1 (en) 2010-02-08 2011-12-06 Abbott Diabetes Care Inc. Analyte meter
EP2361648A1 (en) 2010-02-18 2011-08-31 Sanofi-Aventis Deutschland GmbH Remover for a protective needle shield
JP5807021B2 (ja) 2010-02-18 2015-11-10 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 自動注射器
WO2011101380A1 (en) 2010-02-18 2011-08-25 Sanofi-Aventis Deutschland Gmbh Auto-injector
US9421336B2 (en) 2010-02-18 2016-08-23 Sanofi-Aventis Deutschland Gmbh Finger guard for an injection device
WO2011101383A1 (en) 2010-02-22 2011-08-25 Sanofi-Aventis Deutschland Gmbh Force transmission arrangement for auto-injector
CA2790280A1 (en) 2010-02-22 2011-08-25 Sanofi-Aventis Deutschland Gmbh Auto - injector with needle shroud and needle protection cap
EP2364739A1 (en) 2010-03-09 2011-09-14 Sanofi-Aventis Deutschland GmbH Re-usable autoinjector
AU2011224884B2 (en) 2010-03-09 2013-08-15 Shl Medical Ag Medicament delivery device
JPWO2011111321A1 (ja) 2010-03-11 2013-06-27 パナソニック株式会社 音声読み上げ装置および音声読み上げ方法
GB201004102D0 (en) 2010-03-12 2010-04-28 Liversidge Barry P Syringe barrels and handling systems
US8674288B2 (en) 2010-03-24 2014-03-18 Medtronic Minimed, Inc. Motor assembly sensor capture systems and methods
USD652503S1 (en) 2010-04-08 2012-01-17 Cequr Sa Medical device
WO2011124631A1 (en) 2010-04-09 2011-10-13 Sanofi-Aventis Deutschland Gmbh Coded drug reservoir connection element with bendable locking elements
WO2011129175A1 (ja) 2010-04-16 2011-10-20 株式会社根本杏林堂 シリンジ保持構造
US8810394B2 (en) 2010-04-16 2014-08-19 Medtronic, Inc. Reservoir monitoring for implantable fluid delivery devices
CN201692438U (zh) 2010-04-20 2011-01-05 深圳市利泰尔科技有限公司 配置自动给药传动组件的胰岛素泵
KR101850687B1 (ko) 2010-04-21 2018-04-20 애브비 바이오테크놀로지 리미티드 치료제의 제어된 전달을 위한 착용형 자동 주사 디바이스
EP2560601A2 (en) 2010-04-23 2013-02-27 Sanofi-Aventis Deutschland GmbH Coded ferrule for a drug delivery device
DK2560710T3 (da) 2010-04-23 2014-06-16 Sanofi Aventis Deutschland Kodet formet indsats til en medikamentampul
CA2796570A1 (en) 2010-04-23 2011-10-27 Sanofi-Aventis Deutschland Gmbh Cartridge holder and alignment interface
JP5815672B2 (ja) 2010-04-23 2015-11-17 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング コード化カートリッジ組立体
US8246573B2 (en) 2010-04-27 2012-08-21 Medtronic, Inc. Detecting empty medical pump reservoir
EP2569031B1 (en) 2010-05-10 2017-10-11 Medimop Medical Projects Ltd. Low volume accurate injector
SG10201700716VA (en) 2010-05-20 2017-02-27 Becton Dickinson Co Drug delivery device
FI2575935T4 (fi) 2010-06-07 2023-11-23 Amgen Inc Lääkeaineen vapautuslaite
WO2011154355A1 (en) 2010-06-07 2011-12-15 Sanofi-Aventis Deutschland Gmbh Drug delivery device with light source
US8905910B2 (en) 2010-06-22 2014-12-09 Thoratec Corporation Fluid delivery system and method for monitoring fluid delivery system
EP2399627A1 (en) 2010-06-28 2011-12-28 Sanofi-Aventis Deutschland GmbH Auto-injector
EP2399633A1 (en) 2010-06-28 2011-12-28 Sanofi-Aventis Deutschland GmbH Needle safety arrangement and method for operating it
US9427531B2 (en) 2010-06-28 2016-08-30 Sanofi-Aventis Deutschland Gmbh Auto-injector
EP2399631A1 (en) 2010-06-28 2011-12-28 Sanofi-Aventis Deutschland GmbH Auto-injector with injection damper
EP2399628A1 (en) 2010-06-28 2011-12-28 Sanofi-Aventis Deutschland GmbH Auto-injector
US20110319861A1 (en) 2010-06-29 2011-12-29 Robert Wilk Medical device mechanical pump
CN103037982A (zh) 2010-06-29 2013-04-10 Csp技术公司 具有集成针头的注射器
US8172591B2 (en) 2010-07-05 2012-05-08 Hon Hai Precision Ind. Co., Ltd. Electrical connector assembly having electrical connector with low profile and processor with cone pins
USD650903S1 (en) 2010-07-09 2011-12-20 Becton, Dickinson And Company Syringe barrel
JP2013530778A (ja) 2010-07-13 2013-08-01 ノボ・ノルデイスク・エー／エス ピストンロッドフット
US9675751B2 (en) 2010-07-31 2017-06-13 Becton, Dickinson And Company Infusion reservoir with push-on connector features and/or attachments therefor
US20130204187A1 (en) 2010-08-06 2013-08-08 Sanofi-Aventis Deutschland Gmbh Method and system for retaining a cartridge in a holder
EP2585145B1 (en) 2010-08-19 2014-03-05 West Pharmaceutical Services, Inc. Rigid needle shield
US8764962B2 (en) * 2010-08-23 2014-07-01 Massachusetts Institute Of Technology Extraction of liquid elements by electrolysis of oxides
WO2012032411A2 (en) 2010-09-07 2012-03-15 Tecpharma Licensing Ag Automatic injection device
US9750875B2 (en) 2010-09-24 2017-09-05 Perqflo, Llc Infusion pumps
WO2012045833A1 (en) 2010-10-08 2012-04-12 Sanofi-Aventis Deutschland Gmbh Auto-injector
US8474332B2 (en) 2010-10-20 2013-07-02 Medtronic Minimed, Inc. Sensor assembly and medical device incorporating same
US8495918B2 (en) 2010-10-20 2013-07-30 Medtronic Minimed, Inc. Sensor assembly and medical device incorporating same
US8479595B2 (en) 2010-10-20 2013-07-09 Medtronic Minimed, Inc. Sensor assembly and medical device incorporating same
US9402569B2 (en) 2010-10-28 2016-08-02 Medtronic Minimed, Inc. System and/or method for glucose sensor calibration
US8353869B2 (en) 2010-11-02 2013-01-15 Baxa Corporation Anti-tampering apparatus and method for drug delivery devices
JP4685198B1 (ja) 2010-11-11 2011-05-18 株式会社アルテ 包装用プレート、注射器保持容器及び容器兼用注射器の製造方法
TWI425719B (zh) 2010-11-16 2014-02-01 Compal Electronics Inc 連接埠
US8905972B2 (en) * 2010-11-20 2014-12-09 Perqflo, Llc Infusion pumps
US8446733B2 (en) 2010-11-24 2013-05-21 Lear Corporation Printed circuit board connection assembly
CA2820557A1 (en) 2010-11-29 2012-06-07 Sanofi-Aventis Deutschland Gmbh Auto-injector device with a medicated module
US8795230B2 (en) 2010-11-30 2014-08-05 Becton, Dickinson And Company Adjustable height needle infusion device
GB201020472D0 (en) 2010-12-02 2011-01-19 Oval Medical Technologies Ltd A drive assembly for an autoinjector
EP2468332A1 (en) 2010-12-21 2012-06-27 Sanofi-Aventis Deutschland GmbH Auto-injector
EP2468331A1 (en) 2010-12-21 2012-06-27 Sanofi-Aventis Deutschland GmbH Auto-injector
CN201941304U (zh) 2010-12-22 2011-08-24 刘天野 具有报警功能的档案盒
US8197444B1 (en) 2010-12-22 2012-06-12 Medtronic Minimed, Inc. Monitoring the seating status of a fluid reservoir in a fluid infusion device
US8690855B2 (en) 2010-12-22 2014-04-08 Medtronic Minimed, Inc. Fluid reservoir seating procedure for a fluid infusion device
US8628510B2 (en) 2010-12-22 2014-01-14 Medtronic Minimed, Inc. Monitoring the operating health of a force sensor in a fluid infusion device
US8469942B2 (en) 2010-12-22 2013-06-25 Medtronic Minimed, Inc. Occlusion detection for a fluid infusion device
PE20141543A1 (es) 2011-01-24 2014-11-23 Abbvie Biotechnology Ltd Extraccion de protectores de aguja desde jeringas y dispositivos de inyeccion automatica
EP2489381A1 (en) 2011-02-18 2012-08-22 Sanofi-Aventis Deutschland GmbH Auto-injector
EP2489383A1 (en) 2011-02-18 2012-08-22 Sanofi-Aventis Deutschland GmbH Auto-injector
GB2488579A (en) 2011-03-02 2012-09-05 Owen Mumford Ltd Autoinjector with "injection complete" indicator
USD702834S1 (en) 2011-03-22 2014-04-15 Medimop Medical Projects Ltd. Cartridge for use in injection device
GB2486748B (en) 2011-03-24 2013-04-10 Owen Mumford Ltd Autoinjector devices
US9956345B2 (en) 2011-04-21 2018-05-01 Abbvie Inc. Wearable automatic injection device for controlled administration of therapeutic agents
US8795231B2 (en) 2011-05-10 2014-08-05 Medtronic Minimed, Inc. Automated reservoir fill system
JP6055819B2 (ja) 2011-05-25 2016-12-27 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 薬剤注射デバイスおよびプライミング動作
CA2835512A1 (en) * 2011-05-25 2012-11-29 Sanofi-Aventis Deutschland Gmbh Medicament delivery device with cap
WO2012160164A1 (en) 2011-05-25 2012-11-29 Sanofi-Aventis Deutschland Gmbh Handheld medicament injection device with illuminated dose button
EP2714151B1 (en) 2011-06-02 2017-05-24 UCB Biopharma SPRL Auto-injector
GB201109620D0 (en) 2011-06-09 2011-07-20 Ardehali Massoud H Injection apparatus
US8292647B1 (en) 2011-06-13 2012-10-23 Tyco Electronics Corporation Socket connector
US9821116B2 (en) 2011-07-25 2017-11-21 Preciflex Sa Fluid dispenser
EP2750737A1 (en) * 2011-08-29 2014-07-09 Sid Technologies LLC Subcutaneous and intradermal patch infusers
KR20140050753A (ko) 2011-08-31 2014-04-29 에스에이치엘 그룹 에이비 주사 장치
USD657462S1 (en) 2011-09-02 2012-04-10 I & J Fisnar, Inc. Liquid dispensing syringe barrel
JP6411888B2 (ja) * 2011-09-07 2018-10-24 スリーエム イノベイティブ プロパティズ カンパニー 中空マイクロニードルアレイのための送達システム
JP2014526297A (ja) 2011-09-09 2014-10-06 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 独立した針挿入による自動注射器
EP2574355A1 (en) * 2011-09-27 2013-04-03 Sanofi-Aventis Deutschland GmbH Package for a medicament delivery device
US9597455B2 (en) 2011-09-30 2017-03-21 Becton Dickinson France S.A.S. Syringe having a spring action plunger rod
KR20130038503A (ko) 2011-10-10 2013-04-18 삼성전자주식회사 전자장치의 ｐｂａ 적층구조
CN202236675U (zh) * 2011-10-11 2012-05-30 张晓燕 无残留注射器
CA2852187A1 (en) 2011-10-17 2013-04-25 Shl Group Ab Device for removing delivery member shields
US8603028B2 (en) * 2011-11-18 2013-12-10 Allergan, Inc. Injection device having an angled tip portion
EP2596823A1 (en) 2011-11-24 2013-05-29 Sanofi-Aventis Deutschland GmbH Autoinjector
EP2596822A1 (en) 2011-11-24 2013-05-29 Sanofi-Aventis Deutschland GmbH Autoinjector
US10722645B2 (en) 2011-12-21 2020-07-28 Deka Products Limited Partnership Syringe pump, and related method and system
US20130172808A1 (en) 2011-12-30 2013-07-04 G. Ford Gilbert Medical infusion device producing adenosine triphosphate from carbohydrates
EP2809375B1 (en) 2012-01-31 2021-08-11 Medimop Medical Projects Ltd. Time dependent drug delivery apparatus
DK2819724T3 (da) 2012-02-27 2019-05-27 Hoffmann La Roche Fjederkraftsamling til forspænding eller aktivering af propper i sprøjter, patroner til injektionspenne og lignende
US8603027B2 (en) 2012-03-20 2013-12-10 Medtronic Minimed, Inc. Occlusion detection using pulse-width modulation and medical device incorporating same
US8603026B2 (en) 2012-03-20 2013-12-10 Medtronic Minimed, Inc. Dynamic pulse-width modulation motor control and medical device incorporating same
US8523803B1 (en) 2012-03-20 2013-09-03 Medtronic Minimed, Inc. Motor health monitoring and medical device incorporating same
US9463280B2 (en) 2012-03-26 2016-10-11 Medimop Medical Projects Ltd. Motion activated septum puncturing drug delivery device
US9072827B2 (en) 2012-03-26 2015-07-07 Medimop Medical Projects Ltd. Fail safe point protector for needle safety flap
EP2650032A1 (en) 2012-04-11 2013-10-16 PharmaSens AG Subcutaneous needle insertion mechanism
GB201206766D0 (en) 2012-04-17 2012-05-30 Univ Antwerpen Prefillable intradermal delivery device
ES2600731T3 (es) * 2012-04-30 2017-02-10 Conceptomed As Dispositivos para la transferencia de fluidos
US20130296824A1 (en) * 2012-05-03 2013-11-07 Uc Biodevices Corporation Microneedle based transdermal drug delivery device and method
US9849252B2 (en) 2012-05-04 2017-12-26 Sofia Eleni Armes Electromechanical manipulating device for medical needle and syringe with sensory biofeedback and pain suppression capability
EP2869875A4 (en) * 2012-07-04 2016-03-23 Vigmed Ab Needle protection for an injection needle assembly and injection needle assembly
KR20190135566A (ko) 2012-07-05 2019-12-06 유니트랙트 시린지 피티와이 엘티디 주입 가능한 카트리지용 자동 주입기 및 그 구동 제어 기구
JP6069936B2 (ja) 2012-08-01 2017-02-01 株式会社ジェイ・エム・エス 輸液セット
WO2014023763A1 (en) 2012-08-10 2014-02-13 Sanofi-Aventis Deutschland Gmbh Pen-type drug injection device and electronic add-on monitoring module for|monitoring and logging dose setting and administration
RU2015103182A (ru) * 2012-08-20 2016-10-10 Ф.Хоффманн-Ля Рош Аг Терапевтическая система с адаптером для инфузионного набора
US8808269B2 (en) 2012-08-21 2014-08-19 Medtronic Minimed, Inc. Reservoir plunger position monitoring and medical device incorporating same
EP2712650A1 (en) 2012-09-27 2014-04-02 F. Hoffmann-La Roche AG Adapter and drug cartridge alignment device
US9539384B2 (en) 2012-09-28 2017-01-10 Animas Corporation Telescoping piston drive for medical infusion device
EP2902056B1 (en) * 2012-09-28 2022-04-27 Terumo Kabushiki Kaisha Puncture device and medical fluid application device
US8870818B2 (en) 2012-11-15 2014-10-28 Medtronic Minimed, Inc. Systems and methods for alignment and detection of a consumable component
US9421323B2 (en) 2013-01-03 2016-08-23 Medimop Medical Projects Ltd. Door and doorstop for portable one use drug delivery apparatus
US9033924B2 (en) 2013-01-18 2015-05-19 Medtronic Minimed, Inc. Systems for fluid reservoir retention
US9107994B2 (en) 2013-01-18 2015-08-18 Medtronic Minimed, Inc. Systems for fluid reservoir retention
US9522223B2 (en) 2013-01-18 2016-12-20 Medtronic Minimed, Inc. Systems for fluid reservoir retention
US9089475B2 (en) 2013-01-23 2015-07-28 Icu Medical, Inc. Pressure-regulating vial adaptors
JP6273655B2 (ja) 2013-01-25 2018-02-07 ユーエヌエル ホールディングス エルエルシーＵＮＬ Ｈｏｌｄｉｎｇｓ ＬＬＣ 一体化された流体経路接続部及び薬剤容器
US20140214001A1 (en) 2013-01-31 2014-07-31 Alpimed Sarl Fluid dispensing device
US9308321B2 (en) 2013-02-18 2016-04-12 Medtronic Minimed, Inc. Infusion device having gear assembly initialization
JP6163198B2 (ja) 2013-02-28 2017-07-12 テルモ株式会社 キャップ
US9814871B2 (en) 2013-03-15 2017-11-14 Bayer Healthcare Llc Connector assembly for syringe system
US8979802B2 (en) 2013-03-15 2015-03-17 B. Braun Melsungen Ag Safety IV catheter assembly with seal
US10201662B2 (en) 2013-04-10 2019-02-12 Sanofi Injection device and assembly method
US9011164B2 (en) 2013-04-30 2015-04-21 Medimop Medical Projects Ltd. Clip contact for easy installation of printed circuit board PCB
US9750885B2 (en) 2013-05-01 2017-09-05 Unl Holdings Llc Plunger-driven auto-injectors
CN110841148B (zh) 2013-05-03 2022-04-26 贝克顿·迪金森公司 药物输送装置
WO2014191038A1 (de) * 2013-05-30 2014-12-04 Weibel Cds Ag Vorrichtung zur abgabe eines fluids an einen patienten
WO2014194183A2 (en) 2013-05-31 2014-12-04 Valeritas, Inc. A fluid delivery device having an insertable prefilled cartridge
US9539757B2 (en) * 2013-06-26 2017-01-10 Tekni-Plex, Inc. Packing tray having cell pockets with expandable sidewalls and floating base, and method of manufacture
US20150005703A1 (en) 2013-06-28 2015-01-01 Animas Corporation Drug infusion device with safety interlock
EP2823837A1 (en) 2013-07-09 2015-01-14 Sanofi-Aventis Deutschland GmbH Autoinjector
EP2832390A1 (en) * 2013-07-30 2015-02-04 Sensile Pat AG Drug delivery device with needle actuation mechanism
GB201313782D0 (en) 2013-08-01 2013-09-18 Oval Medical Technologies Ltd Drug delivery device
US9211799B2 (en) 2013-08-15 2015-12-15 Telefonix, Inc. Mechanism for locking and fault detection in the electrical vehicle supply equipment cord
EP3041527B1 (en) * 2013-09-05 2018-05-09 Sanofi-Aventis Deutschland GmbH Drive mechanism for a needle insertion arrangement
US10046111B2 (en) 2013-09-05 2018-08-14 Sanofi-Aventis Deutchland Gmbh Needle insertion and retraction arrangment with manually triggered, spring-loaded drive mechanism
TR201905944T4 (tr) 2013-09-05 2019-05-21 Sanofi Aventis Deutschland Bir iğne yerleştirme düzeneğine yönelik tahrik mekanizması.
EP3047867B1 (en) * 2013-09-19 2020-08-19 Terumo Kabushiki Kaisha Needle-equipped syringe
US20160228652A1 (en) 2013-09-30 2016-08-11 Medimop Medical Projects Ltd. Needle retraction mechanism for autoinjector
EP3656425B1 (en) 2013-09-30 2024-02-21 Medimop Medical Projects Ltd Stabilized pen injector
US20150112278A1 (en) 2013-10-21 2015-04-23 Optima MDevice Technology Corporation Systems and Methods for Needle for Subclavian Vein Penetration
TWI569832B (zh) 2013-10-23 2017-02-11 卡貝歐洲有限公司 藥物輸送裝置
US9463889B2 (en) 2013-10-25 2016-10-11 Medtronic, Inc. Prefilled reservoir apparatus for ambulatory infusion device
DE102013112167A1 (de) * 2013-11-05 2015-05-07 Schott Ag Haltestruktur zum gleichzeitigen Halten einer Mehrzahl von Behältern für Substanzen für medizinische, pharmazeutische oder kosmetische Anwendungen sowie Transport- und Verpackungsbehälter mit Selbiger sowie Verfahren
EP2878321A1 (en) 2013-11-28 2015-06-03 Sanofi-Aventis Deutschland GmbH Needle safety device and drug delivery device
CN106029123A (zh) 2013-12-20 2016-10-12 赛诺菲-安万特德国有限公司 用于药物输送装置的一次性输送组件
EP2886144A1 (en) 2013-12-20 2015-06-24 Sanofi-Aventis Deutschland GmbH Drug delivery device
AU2014380934B2 (en) 2014-01-31 2019-08-22 Industrie Borla S.P.A. Valved connector for medical lines
US20170007774A1 (en) 2014-02-03 2017-01-12 Novo Nordisk A/S Telescopic Drive Arrangement
GB201402261D0 (en) * 2014-02-10 2014-03-26 Owen Mumford Ltd Injector apparatus
US20170175859A1 (en) 2014-02-17 2017-06-22 Novo Nordisk A/S Telescopic Drive Arrangement with Oldham Coupling
EP3113777A4 (en) 2014-03-04 2017-09-06 The Children's Hospital of Philadelphia Methods for managing care of patients predisposed to progressive mitral valve diseases
TWI616218B (zh) 2014-03-06 2018-03-01 卡貝歐洲有限公司 輸送藥物的裝置
WO2015138261A1 (en) 2014-03-12 2015-09-17 Min Wei Automatic medication injection device
WO2015151936A1 (ja) * 2014-03-31 2015-10-08 テルモ株式会社 射出成型用金型
US10335550B2 (en) 2014-04-25 2019-07-02 Phc Holdings Corporation Pharmaceutical injection device
GB2530714A (en) 2014-08-20 2016-04-06 Owen Mumford Ltd Injection devices
JP6409122B2 (ja) 2014-09-02 2018-10-17 イーライ リリー アンド カンパニー 流体容器中のプランジャの位置を判定する検知システム
JP6422278B2 (ja) 2014-09-19 2018-11-14 ルネサスエレクトロニクス株式会社 電力制御回路
KR102140250B1 (ko) 2014-09-22 2020-07-31 주식회사 디비하이텍 출력 버퍼, 이를 포함하는 소스 드라이버 및 디스플레이 장치
GB2532300B (en) 2014-09-30 2018-09-19 Owen Mumford Ltd Injection devices
EP3215203B1 (en) 2014-11-04 2019-12-25 SHL Medical AG Autoinjector with delayed signal of complete medication delivery
US20160144117A1 (en) 2014-11-21 2016-05-26 Thomas Chun Hypodermic syringe that automatically ejects medicament from a needle
EP3028946A1 (en) 2014-12-05 2016-06-08 F. Hoffmann-La Roche AG Preparing a double chamber container
EP3028947A1 (en) 2014-12-05 2016-06-08 F. Hoffmann-La Roche AG Closing a chamber of a container for a pharmaceutical product
ES2898469T3 (es) 2014-12-19 2022-03-07 Amgen Inc Dispositivo de administración de medicamentos con sensor de proximidad
JP6752808B2 (ja) 2015-03-02 2020-09-09 アムジエン・インコーポレーテツド 無菌接続を形成する装置
US10293120B2 (en) 2015-04-10 2019-05-21 West Pharma. Services IL, Ltd. Redundant injection device status indication
US10149943B2 (en) 2015-05-29 2018-12-11 West Pharma. Services IL, Ltd. Linear rotation stabilizer for a telescoping syringe stopper driverdriving assembly
TW201707740A (zh) 2015-06-03 2017-03-01 賽諾菲阿凡提斯德意志有限公司 藥物輸送裝置（四）
JP6703813B2 (ja) 2015-08-06 2020-06-03 国立大学法人横浜国立大学 冷却装置、およびモータ
US10576207B2 (en) * 2015-10-09 2020-03-03 West Pharma. Services IL, Ltd. Angled syringe patch injector
DE102016201268A1 (de) * 2016-01-28 2017-08-03 Schott Schweiz Ag Trägerplatte für pharmazeutische Behältnisse
JOP20170042B1 (ar) 2016-02-12 2022-09-15 Amgen Inc وسيلة توصيل عقار، طريقة تصنيعه وطريقة استخدامه
WO2017161076A1 (en) 2016-03-16 2017-09-21 Medimop Medical Projects Ltd. Staged telescopic screw assembly having different visual indicators
US10376647B2 (en) 2016-03-18 2019-08-13 West Pharma. Services IL, Ltd. Anti-rotation mechanism for telescopic screw assembly
EP3437676B1 (en) 2016-03-30 2021-08-11 Terumo Kabushiki Kaisha Liquid medicine administration device
EP3260147A1 (en) 2016-06-23 2017-12-27 TecPharma Licensing AG A segmented piston rod for a medication delivery device
US10898658B2 (en) 2016-07-06 2021-01-26 LynJohnston, LLC Compact injection device with telescoping components
FR3055216A1 (fr) 2016-08-31 2018-03-02 Nemera La Verpilliere Dispositif d'injection automatique a agencement optimise
USD838367S1 (en) * 2016-09-26 2019-01-15 West Pharma. Services IL, Ltd. Syringe barrel
CN110520175B (zh) 2017-01-20 2022-03-29 L.G.P.科技控股有限公司 自动注射器装置
GB2560524B (en) 2017-03-13 2019-07-31 Univ Cape Town An auto-injector
GB201704143D0 (en) 2017-03-15 2017-04-26 Owen Mumford Ltd Low force trigger
CN110869072B (zh) 2017-05-30 2021-12-10 西部制药服务有限公司(以色列) 用于穿戴式注射器的模块化驱动机构
EP4389173A2 (en) 2017-07-07 2024-06-26 Neuroderm Ltd Device for subcutaneous delivery of fluid medicament
US20190071217A1 (en) * 2017-09-01 2019-03-07 Pinnpack Packaging, Llc Cup cake tray
JP7086976B2 (ja) 2017-09-29 2022-06-20 テルモ株式会社 プランジャ組立体、薬液投与装置及びプランジャ組立体の駆動方法
CA3099230A1 (en) 2018-05-24 2019-11-28 Novartis Ag Automatic drug delivery device
KR102549081B1 (ko) 2018-12-14 2023-07-03 에스에이치엘 메디컬 아게 자동 주사기
WO2020193468A1 (en) 2019-03-22 2020-10-01 Phillips-Medisize A/S Auto injector with bi-stable clutch plate
US11278669B2 (en) 2020-01-21 2022-03-22 Repro Med Systems, Inc. Gear-driven infusion assemblies, systems, and methods

Also Published As

Publication number Publication date
US20180296762A1 (en) 2018-10-18
EP3162401A3 (en) 2017-08-09
WO2017062935A1 (en) 2017-04-13
CN108430537B (zh) 2021-02-19
JP6831386B2 (ja) 2021-02-17
US11724034B2 (en) 2023-08-15
US20190083709A1 (en) 2019-03-21
JP2021168962A (ja) 2021-10-28
WO2017062943A2 (en) 2017-04-13
CN108430537A (zh) 2018-08-21
EP3359219B1 (en) 2023-12-06
WO2017062930A1 (en) 2017-04-13
JP2018532525A (ja) 2018-11-08
US20180296763A1 (en) 2018-10-18
US20220347388A1 (en) 2022-11-03
EP3162401B1 (en) 2019-01-23
EP3359232B1 (en) 2020-06-17
JP2018535068A (ja) 2018-11-29
US20190374719A1 (en) 2019-12-12
JP6840761B2 (ja) 2021-03-10
EP3359219A1 (en) 2018-08-15
US11759573B2 (en) 2023-09-19
EP3359223B1 (en) 2020-05-20
WO2017062932A1 (en) 2017-04-13
EP3359232A2 (en) 2018-08-15
CN108367114A (zh) 2018-08-03
WO2017062938A1 (en) 2017-04-13
EP3359231A1 (en) 2018-08-15
CN108430547A (zh) 2018-08-21
US11110224B2 (en) 2021-09-07
CN108430547B (zh) 2020-12-11
WO2017062943A3 (en) 2017-05-26
EP3359231B1 (en) 2020-07-22
US20230372624A1 (en) 2023-11-23
US20210361871A1 (en) 2021-11-25
EP3359224A1 (en) 2018-08-15
US10695496B2 (en) 2020-06-30
US10828421B2 (en) 2020-11-10
EP3359222B1 (en) 2020-09-23
US11116908B2 (en) 2021-09-14
US20180311440A1 (en) 2018-11-01
WO2017062938A8 (en) 2017-08-31
WO2017062933A1 (en) 2017-04-13
CN108367114B (zh) 2021-05-11
US20180318511A1 (en) 2018-11-08
US20210361870A1 (en) 2021-11-25
CN108697863B (zh) 2021-05-11
JP2018532528A (ja) 2018-11-08
EP3708202A1 (en) 2020-09-16
US20190060572A1 (en) 2019-02-28
CN108430546A (zh) 2018-08-21
US10576207B2 (en) 2020-03-03
US20170100542A1 (en) 2017-04-13
CN106964013B (zh) 2021-09-07
JP6571878B2 (ja) 2019-09-04
EP3359222A1 (en) 2018-08-15
EP3359228A1 (en) 2018-08-15
US11027070B2 (en) 2021-06-08
US10589028B2 (en) 2020-03-17
JP2018531134A (ja) 2018-10-25
JP7250858B2 (ja) 2023-04-03
JP6633766B2 (ja) 2020-01-22
US20200121854A1 (en) 2020-04-23
CN106964013A (zh) 2017-07-21
US10369289B2 (en) 2019-08-06
JP2018535067A (ja) 2018-11-29
CN114344609A (zh) 2022-04-15
US11547802B2 (en) 2023-01-10
CN108697863A (zh) 2018-10-23
WO2017062931A1 (en) 2017-04-13
EP3162401A2 (en) 2017-05-03
EP3359223A1 (en) 2018-08-15

Similar Documents

Publication Publication Date Title
CN108430546B (zh) 用于流体输送的具有减小的死区的医疗装置
US7988663B2 (en) Retractable needle syringe assembly
US7033337B2 (en) Medical device
EP1284764B1 (en) Medical device
US20100292643A1 (en) Autoinjector With Needle Depth Adapter
US20090227942A1 (en) Skin Retention Device for a Medical Jet Injection Unit
CN107530506A (zh) 一种具有用于针的清洗腔室的带伸缩式可移动针护罩的医疗注射装置
JP2001137343A (ja) 針アセンブリ、これを具えた皮下注射装置、及び皮下注射方法
JPH1080485A (ja) 連続動作ストッパー
US20140170594A1 (en) Dual medicament carpule for dental syringes
JP6766802B2 (ja) マイクロニードル
WO2008056442A1 (en) Mechanism capable of providing neat cleaved opening surface and ampule with movable gasket
US20110118665A1 (en) Disposable carpule for hypodermic syringe
JP2011510719A (ja) 人体の皮膚を経由しあるいはその内部に流体を注射するシステム
JP6175066B2 (ja) 短いカニューレを備えたバレル−プランジャ・ユニット
CN113195018A (zh) 用于物质的独立储存的药物储存器
CN116669797A (zh) 具有护针器的医用注射器
CN116077768A (zh) 低死区针头毂

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant