EP3000498B1 - Autoinjector - Google Patents

Autoinjector Download PDF

Info

Publication number
EP3000498B1
EP3000498B1 EP15184955.1A EP15184955A EP3000498B1 EP 3000498 B1 EP3000498 B1 EP 3000498B1 EP 15184955 A EP15184955 A EP 15184955A EP 3000498 B1 EP3000498 B1 EP 3000498B1
Authority
EP
European Patent Office
Prior art keywords
syringe
spring
plunger
autoinjector
drive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP15184955.1A
Other languages
German (de)
French (fr)
Other versions
EP3000498A2 (en
EP3000498A3 (en
Inventor
Toby Cowe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Owen Mumford Ltd
Original Assignee
Owen Mumford Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GBGB0918443.3A priority Critical patent/GB0918443D0/en
Priority to GBGB1017363.1A priority patent/GB201017363D0/en
Priority to US39489610P priority
Application filed by Owen Mumford Ltd filed Critical Owen Mumford Ltd
Priority to EP10781990.6A priority patent/EP2490735B1/en
Publication of EP3000498A2 publication Critical patent/EP3000498A2/en
Publication of EP3000498A3 publication Critical patent/EP3000498A3/en
Application granted granted Critical
Publication of EP3000498B1 publication Critical patent/EP3000498B1/en
Application status is Active legal-status Critical
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/20Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033Spring-loaded one-shot injectors with or without automatic needle insertion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202Devices for protection of the needle before use, e.g. caps
    • A61M5/3204Needle cap remover, i.e. devices to dislodge protection cover from needle or needle hub, e.g. deshielding devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/20Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/206With automatic needle insertion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/20Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2073Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321Means for protection against accidental injuries by used needles
    • A61M5/3243Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/3245Constructional features thereof, e.g. to improve manipulation or functioning
    • A61M2005/3247Means to impede repositioning of protection sleeve from needle covering to needle uncovering position
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/58Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/581Means for facilitating use, e.g. by people with impaired vision by audible feedback
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/58Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/582Means for facilitating use, e.g. by people with impaired vision by tactile feedback
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/58Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501Means for blocking or restricting the movement of the rod or piston
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321Means for protection against accidental injuries by used needles
    • A61M5/3243Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/326Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user

Description

  • This invention relates to autoinjectors.
  • There is a need for autoinjectors which are of compact form so that they can be carried and used unobtrusively and further which are simple to manufacture, assemble and use with consequent savings in manufacturing and assembly costs, and a lower environmental impact.
  • One example of prior art autoinjector is given in WO 2009/063030 A1 .
  • Accordingly, in one aspect, this invention provides an autoinjector for receiving in use a syringe containing a dose of medicament, said syringe comprising a syringe body of generally cylindrical form, a needle at the forward end of the syringe body, and a piston slideably mounted in said syringe body for expressing a dose, said autoinjector comprising:
    • a housing for receiving in use said syringe for sliding movement between a retracted position and an extended, injection position in which said needle projects from said housing;
    • a drive mechanism for being released from an energised condition to drive the syringe forwards to the injection position and to expel a dose;
    wherein said drive mechanism includes:
    • a plunger adapted to drive said piston in use;
    • an intermediate drive member;
    • a first compression drive spring disposed between said intermediate drive member and said housing or a part associated therewith to urge said intermediate drive member forwardly, and
    • a second compression spring acting between said intermediate drive member and said plunger to urge said plunger forwardly,
    • the intermediate drive member having an internal cylindrical space for receiving the rear end of said second compression spring, whereby following release of said drive mechanism, the second spring, as it expands, is surrounded along at least a major portion of its length by at least one of the cylindrical space and the internal bore of the syringe body.
  • In this arrangement, the external support provided to the second compression spring means that a long spring of relatively narrow diameter may be used without the risk of snaking or the need to provide an internal support along its length. In turn, the ability to use a relatively low diameter spring means that in preferred embodiments, the spring can be designed to fit into the interior of the syringe body rather than expanding exteriorly, and this means that the overall length of the device may be reduced as less of the expansion takes place outside the syringe, thereby providing a compact design. It will be appreciated that the second spring could act directly on the piston if the latter is suitably formed.
  • Preferably the intermediate member comprises a generally cylindrical body, closed at its rear end. In this fashion, the intermediate member provides an internal cylindrical wall surface for externally constraining at least part of the second spring, and an external cylindrical surface for internally constraining at least part of the first spring.
  • Conveniently, the autoinjector is configured so that, upon release of the drive mechanism, the intermediate member is urged close to or in contact with the rear end of the syringe, thereby substantially completely to enclose the second spring to constrain it externally. Preferably, the drive mechanism includes a trigger arrangement adapted releasably to prevent movement of the intermediate member from a cocked position. The trigger arrangement preferably includes a latch member engageable with an abutment surface on said intermediate member. The abutment surface preferably is disposed between the forward end of the intermediate member and the rearward end of the syringe when in said cocked position. Preferably, the trigger arrangement is released by a trigger element, which may be biased away from its release position by one or both of the drive springs. It is common in autoinjectors to provide a small spring to provide a bias or controlled resistance to the firing button, and to prevent free motion or rattling. By using the drive spring to supply a bias, an extra spring is not required for this purpose. This is a significant benefit in automatically assembled devices, where spring handling and detangling can be problematic.
  • Many existing autoinjectors require some system of mechanical sequencing or latch to sequence the syringe advance movement and the syringe plunger movement of the autoinjector. Such mechanisms add to the complexity of the autoinjector and also contribute to its length. Accordingly, we have designed a compact autoinjector which does not require such mechanisms and in which, immediately on release of the drive mechanism, the plunger and the intermediate member are free for relative movement. In the conventional mechanisms described above, the intermediate member and the plunger continue to be actively locked against movement until they have reached a forward position, where they are unlatched.
  • Accordingly, in another aspect, this invention provides an autoinjector for receiving in use a syringe containing a dose of medicament, said syringe comprising a syringe body of generally cylindrical form, a needle at the forward end of the syringe body, and a piston slideably mounted in said syringe body for expressing a dose, said autoinjector comprising:
    • a housing for receiving in use said syringe for sliding movement between a retracted position and an extended, injection position in which said needle projects from said housing;
    • a drive mechanism for being released from an energised condition to drive the syringe forwards to the injection position and to expel a dose;
    wherein said drive mechanism includes:
    • a plunger adapted to drive said piston in use;
    • an intermediate drive member;
    • a first compression drive spring disposed between said intermediate drive member and said housing or a part associated therewith to urge said intermediate drive member forwardly, and
    • a second compression spring acting between said intermediate drive member and said plunger to urge said plunger forwardly,
    wherein immediately on release of said drive mechanism said intermediate drive member and said plunger are freed for relative movement.
  • In yet another aspect there is provided an autoinjector for receiving in use a syringe containing a dose of medicament, said syringe comprising a syringe body of generally cylindrical form, a needle at the forward end of the syringe body, and a piston slideably mounted in said syringe body for expressing a dose,
    said autoinjector comprising:
    • a housing for receiving in use said syringe for sliding movement between a retracted position and an extended, injection position in which said needle projects from said housing;
    • a drive mechanism being released from an energised condition to drive the syringe forwards to the injection position and to expel a dose;
    wherein said drive mechanism includes:
    • a plunger adapted to drive said piston in use;
    • an intermediate drive member;
    • a first compression drive spring disposed between said intermediate drive member and said housing or a part associated therewith to urge said intermediate drive member forwardly, and
    • a second compression spring acting between said intermediate drive member and said plunger to urge said plunger forwardly,
    wherein the second spring is selected such that the spring force it exerts when substantially fully compressed is less than the force required to overcome the static friction between the piston and the syringe body, but greater than the force required to maintain movement of the piston once the static friction has been overcome by the residual force in the first spring when the syringe is in its injection position.
  • Whilst the invention has been described above, it extends to any inventive combination feature disclosed in the description or drawings.
  • The invention may be performed in various ways and several embodiments thereof will now be described in detail, by way of example only, reference being made to the accompanying drawings, in which:
    • Figure 1 is a section view of a first embodiment of autoinjector of this invention in a pre-use cocked position;
    • Figure 2 is a section view of the embodiment of Figure 1, with the trigger button depressed and the syringe moved forwardly ready to deliver a dose,
    • Figure 3 is a section view of the embodiment of Figures 1 and 2, following expulsion of a dose;
    • Figures 4 to 7 are section views of a second embodiment of autoinjector;
    • Figure 8 is an exploded view of a third embodiment of an autoinjector in accordance with this invention;
    • Figure 9 is a side section view through the autoinjector of Figure 8 assembled and prior to use;
    • Figures 10(a) and (b) are respective side and top section views of the autoinjector with the cap in place, and removed;
    • Figures 11 (a) and (b) are respective side and top section views of the autoinjector with the firing button partially depressed immediately prior to the release of the plunger;
    • Figures 12(a), (b) and (c) are respective side section views showing the autoinjector with the syringe in its forwardmost position, shortly after breakout of the piston, and at the injection complete stage respectively;
    • Figure 13 is a view of the device after use, with the shroud extended and locked out by the magnetically enabled latch;
    • Figure 14 is a side view through a fourth embodiment of an autoinjector, and
    • Figure 15 is a shaded side view of the fourth embodiment.
  • Referring initially to Figure 1, the autoinjector comprises an outer housing 10 of cylindrical form in the bore of which is slideably located a syringe 12. The syringe 12 is of generally conventional form comprising a syringe body 14 having a flange 16 at its rear end with a needle 18 projecting from the front end. A piston 20 is slideably contained in the syringe body for expulsion of a medicament 22. The syringe 12 can slide in the housing from a rearward position as shown in Figure 1, against a bias provided by a compression spring 24, to a forward position defined by an internal shoulder 26 on the housing and the compressed spring 24, in which the needle 18 projects from the housing. The syringe is centrally located in the housing by a rib 28 on the body.
  • In the rear end of the housing 10 is provided a drive mechanism for the autoinjector. This comprises first and second compression springs 30, 32 that act in tandem via an intermediate member 34 on a plunger member 42. At its rear end, the first spring 30 is anchored in an internal bore of a trigger button 38, which is captive to the housing. The trigger button may be moved from the rearward position shown in Figure 1 to the forward position shown in Figures 2 and 3 to fire the device as to be described below. The forward end of the first spring 30 surrounds the closed rear end of the intermediate member 34 and abuts a collar 37 on the outside thereof. The rear end of the second spring 32 engages the inner closed rear end of the intermediate member 34 and is externally constrained thereby. The front end of the second spring abuts a shoulder 40 on a plunger 42 which has a rear stem 44 that fits within the compressed second spring as shown in Figures 1 and 2.
  • The plunger 42 has a frustoconical latch surface 46 which is latched by a pair of latch fingers 48 pivoted on the housing 10. The latch fingers 48 are constrained against pivoting movement when the trigger button 38 is in its rear position as shown in Figure 1, but splay outwards to release the plunger 42 when the trigger button is pushed to its forward position. The trigger button has apertures into which the rear ends of the latch fingers 48 can pivot when the button is pushed forwardly.
  • In use, from the position shown in Figure 1, the autoinjector is offered up to the injection site with the front end in contact with the skin. After removing any safety catch, the trigger button 38 is pressed in against a bias afforded by the first spring 30 so that the latch fingers pivot to release the plunger 42 and intermediate member 34 for forward movement. The first spring 30 is stronger than the second spring 32 and so, initially, the intermediate member 34 plunger 42, piston 20, and syringe 14 move as one under the influence of the first spring to drive the syringe to its forward position to extend the needle. During this phase, the reaction or resistance to the forward movement of the syringe as the syringe moves forwardly in the housing and the needle penetrates the flesh is relatively low and less than the break out force required to advance the piston down the syringe. Having reached its forward position, the syringe is arrested, and continued expansion of the first spring pushes the intermediate member 34 towards the now stationary syringe until the collar 37 of the intermediate member is butted up against the rear end of the syringe (Figure 2). As this occurs the intermediate member 34 initially closes towards the plunger 42, slightly further compressing the second spring 32, until the second spring is fully compressed, whereupon the intermediate member 34, the plunger 42 and piston 20 shift forwards relative to the syringe so that, following arrest of the syringe, the more powerful thrust of the first spring 30 is utilised to overcome the static friction or break out force between the piston and the syringe body. Thereafter, the second spring 32 urges the piston forwards to expel a dose, whilst the intermediate member remains butted up against the rear of the syringe. During this latter phase of operation, the second spring is wholly externally enclosed in the internal space defined between the syringe and the intermediate member. In addition, the harnessing of the power of the first spring 30 to overcome the static friction between the piston and the syringe means that the second spring can be less powerful as it only needs to provide a glide force and to pressurise the medicament to exit the needle.
  • Turning now to the second embodiment illustrated in Figures 4 to 7, this is similar in many respects to the first embodiment and like parts are given like references. The main difference is in the design of the intermediate member 34. In the second embodiment the intermediate member has a further cylindrical shell section 39 that extends forwardly of the collar 37 and can enter the rear end of the syringe. In this embodiment the cylindrical shell section offers fully enclosed support of the second spring 32 until it expands with the body of the syringe. Without such a shell a forward portion of the spring is exposed in the initial stages, but equally in this case the second spring diameter can be increased to approximately the inner diameter of the syringe, which can be advantageous.
  • Referring now to Figures 8 to 11, the third embodiment of autoinjector comprises an outer housing 110 of cylindrical form in the bore of which is disposed a syringe 112 of known form with a barrel 114, a needle 116 extending from the forward end, and a flange 118 at its rear end. A medicament is contained within the syringe and can be expressed through the needle by a piston 120 inside the barrel. The syringe is supported and surrounded by moulded plastics shroud/carrier 122 assembly comprising a forward hollow cylindrical portion 124 integrally formed with diametrically opposed springs 126 to either side, and a collar 128 adapted to engage the forward face of the syringe flange. Extending rearwardly from the collar are two diametrically opposed clearance fingers 130 with barbed teeth 132 that engage the intermediate member, to ensure that the collar 128 and thus the syringe 112 cannot separate by more than a short distance from the intermediate member 142 described below when the needle shield is pulled off the syringe prior to injection. The barbed teeth 132 run in respective diametrically opposed grooves 134 on the inner surface of the rear part of the housing. In the pre-use position, the shroud portion 124 is telescopically received within the forward end of the housing and coterminous therewith.
  • In the rear of the housing is provided a drive mechanism which comprises a first outer spring 136 which acts between the front face of a transverse inner wall 138 at the rear of the housing and a forward flange 140 of a top hat-shaped intermediate member 142. An inner, second, spring 144 is received within a cylindrical part of the intermediate member 142 and acts between an inner face of the rear end wall thereof and a circumferential rib 146 on the forward part of a plunger 148. At the rear end, the plunger has a resilient hooked arm 150 (see Figures 8, 11(b)) which latches around the edge of an aperture in the transverse inner wall 138 of the housing. Projecting rearwardly from the rear end of the housing is a captive axially slideable trigger button 152 movable against a rearward bias from the position shown in e.g. Figure 11 (a), where a release finger 154 is spaced rearwardly of the hooked arm 150, to a forward position (Figure 11 (b)) where the finger 154 cams the hooked arm to release its retention by the wall 138, thereby allowing the springs 136, 144 to drive the plunger 148 forwardly. The plunger is shaped and sized so that it can pass into and down the internal bore of the syringe barrel 114, to urge the piston 120 to express a dose. In the forward end of the plunger is a cylindrical recess in which is located a small powerful magnet 156.
  • The trigger button 152 is biased rearwardly by means of two integral forwardly extending sprung arms 158 with cam surfaces 160 which ride over respective abutments 162 inside the rear of the housing. However, initially, forward movement of the trigger button is prevented by means of two rearwardly extending locking arms 164 which extend back from the rear end of a cap 166. The cap covers the whole of the forward end of the housing and has a re-entrant cylindrical portion 168 with claw features 170. The claw features 170 slip over the rear end of a needle shield 172 which is secured to the front end of the needle during manufacture. Thus the cap 166 fulfils the functions of acting as a safety catch for the trigger button 152, serving as a shield remover.
  • Anchored inside the forward end of the housing is a latch 174 formed of pressed steel or other ferro-magnetic material to provide two latch arms 176 which extend forwardly from an anchorage normally to sit in an annular space between the shroud 124 and an inner part of the housing wall.
  • In operation, the user pulls the cap 66 off forwardly which removes the needle shield 122 from the syringe and arms the device by rendering the trigger button 152 operational. The user then offers the injection device up to the injection site and presses the trigger button 152. This releases the hooked arm 150 of the plunger 148 as shown more particularly in Figure 12(b). Once the plunger is released, the first spring 136 expands to extend the syringe 120 so that the needle penetrates the flesh. During this period (Figure 13(a)), the second spring 144 remains substantially fully compressed, with the plunger 148 bearing against the piston 210 within the syringe but not moving it relative to the syringe, so that the thrust of the first spring is transmitted via the intermediate member 142, the compressed second spring and the piston to the syringe.
  • At its extended position, the syringe is arrested by the compression spring portions 126 bottoming out, the shroud 124 being held against movement by contact with the skin surface. When the syringe is arrested, the first spring 136 continues to expand to drive the flange 140 of the intermediate member into engagement with the syringe flange 118 thereby contributing to the force required to initiate movement of the piston down the syringe (Figure 12(b)). From this position the second spring 144 expands to drive the piston down the barrel of the syringe to express a dose. At the end of its travel, it will be noted that the magnet 156 in the plunger is spaced between the latching arms 176 of the latch 174, as shown in Figure 12(c). When the dose has been expressed, the user pulls the device away from the flesh and so the shroud portion 124 is free to expand under the influence of the compression spring portions 126. The shroud portion is driven by the springs 126 forwardly beyond the front tips of the latching arms 176. Once this happens, the latching arms are free to move inwardly to the latching positions shown in Figure 13, under the influence of the magnet 120. The shroud portion 124 is therefore locked out and the device thereby rendered safe.
  • In other embodiments, not shown, further magnets or ferro-magnetic material may be disposed in the front end of the housing around or in front of the syringe in order to provide a magnetic boost effect as the plunger nears the end of its stroke.
  • Referring now to Figures 14 and 15 the fourth embodiment has many of the same components as the third embodiment and which act in a similar fashion. These components are given the same reference numbers and will not therefore be described in detail again. This second embodiment incorporates a magnetic coupling embodiment between the plunger 148 and the syringe designed so that during an initial penetration phase of movement the plunger is coupled magnetically to a thrust collar 180 of ferro-magnetic material that is positioned in contact with the rear face of the syringe flange 118. Thus the plunger 148 and the syringe 118 are initially held against relative movement and so move as one during this phase, until the syringe is arrested by reaching its forwardmost position, with the needle inserted into the injection site. Upon arrest of the syringe, the spring force acting on the plunger overcomes the magnetic coupling force and the coupling yields so that the plunger is released to move forward relative to the syringe to move the plunger into contact with and to urge the piston forwardly to expel a dose. As previously, as the plunger moves alongside the ferro-magnetic latching arms 176 and they are attracted inwardly. This is enhanced in the embodiment by provision of two magnets 182 on the forward ends of the latching arms. These magnets are aligned so as to be attached towards and to exert a pull on the magnet 156 in the plunger to provide a magnetically influenced forward boost to the plunger toward the forwardmost end of its stroke. Upon completion of the injection and removal of the device from the site, the shroud 124 extends forwardly as the spring portions 126 reexpand, and as a rearward lip on the shroud passes the magnets, the latching arms move inwards to block retraction movement of the shroud and thereby lock it out. The magnets 182 may be housed slideably in through-holes in the housing wall, allowing them also to move inwards with the latching arms as the rearward lip on the shroud passes the magnets, and so provide a visual and tactile confirmation of locking out of the shroud 124.
  • In either of the embodiments incorporating magnetic latching, the latches may be arranged that they, or a component associated therewith, emits an audible click as the mechanism latches, thereby to confirm that the injection is complete.

Claims (9)

  1. An autoinjector for receiving in use a syringe containing a dose of medicament, said syringe (12) comprising a syringe body (14) of generally cylindrical form, a needle (18) at the forward end of the syringe body, and a piston (20) slideably mounted in said syringe body for expressing a dose,
    said autoinjector comprising:
    a housing (10) for receiving in use said syringe (12) for sliding movement between a retracted position and an extended, injection position in which said needle (18) projects from said housing;
    a drive mechanism (30-36) for being released from an energised condition to drive the syringe forwards to the injection position and to expel a dose;
    wherein said drive mechanism includes:
    a plunger (36) adapted to drive said piston (20) in use;
    an intermediate drive member (34);
    a first compression drive spring (30) disposed between said intermediate drive member and said housing or a part associated therewith to urge said intermediate drive member forwardly (34), and
    a second compression spring (32) acting between said intermediate drive member and said plunger to urge said plunger (36) forwardly,
    wherein the second spring (32) is selected such that the spring force it exerts when substantially fully compressed is less than the force exerted by the first spring when it is fully expanded the syringe is in its injection position.
  2. An autoinjector for receiving in use a syringe containing a dose of medicament, said syringe (12) comprising a syringe body (14) of generally cylindrical form, a needle (18) at the forward end of the syringe body, and a piston (20) slideably mounted in said syringe body for expressing a dose,
    said autoinjector comprising:
    a housing (10) for receiving in use said syringe (12) for sliding movement between a retracted position and an extended, injection position in which said needle (18) projects from said housing;
    a drive mechanism (30-36) for being released from an energised condition to drive the syringe forwards to the injection position and to expel a dose;
    wherein said drive mechanism includes:
    a plunger (36) adapted to drive said piston (20) in use;
    an intermediate drive member (34);
    a first compression drive spring (30) disposed between said intermediate drive member and said housing or a part associated therewith to urge said intermediate drive member forwardly (34), and
    a second compression spring (32) acting between said intermediate drive member and said plunger to urge said plunger (36) forwardly,
    wherein, prior to release of said drive mechanism said first compression spring exerts a stronger spring force than said second compression spring.
  3. An autoinjector according to claim 1 or 2, wherein there is little or no expansion of said second spring (32) before the first spring (30) has fully expanded.
  4. An autoinjector according to any preceding claim, wherein the intermediate drive member (34) has an internal cylindrical space for receiving the rear end of said second compression spring (32), whereby following release of said drive mechanism (30-36), as it expands the second spring is surrounded along at least a major portion of its length by at least one of the cylindrical space and the internal bore of the syringe body.
  5. An autoinjector according to any preceding Claim 1, wherein the intermediate drive member (34) comprises a generally cylindrical body providing an internal cylindrical support surface for externally constraining the second spring (32) and an external cylindrical surface for internally constraining the first spring (30).
  6. An autoinjector according to any of the preceding claims, wherein upon release of said drive mechanism (30-36), said intermediate member (34) is urged close to or in contact with the rear end of the syringe, thereby substantially completely to enclose the second spring (32) to constrain it externally.
  7. An autoinjector according to any preceding claim, including a trigger arrangement (38, 48) adapted releasably to prevent movement of the intermediate member (34) from a cocked position.
  8. An autoinjector according to Claim 7, wherein the trigger arrangement includes a latch member (48) engageable with an abutment surface (46) on the plunger (42), and releasable by a trigger button (38).
  9. An autoinjector according to Claim 8, wherein the rearward end of said first spring (30) acts on the trigger button to bias it away from the release position.
EP15184955.1A 2009-10-21 2010-10-21 Autoinjector Active EP3000498B1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GBGB0918443.3A GB0918443D0 (en) 2009-10-21 2009-10-21 Autoinjector
GBGB1017363.1A GB201017363D0 (en) 2010-10-14 2010-10-14 Injection devices
US39489610P true 2010-10-20 2010-10-20
EP10781990.6A EP2490735B1 (en) 2009-10-21 2010-10-21 Autoinjector

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18166692.6A EP3366337A3 (en) 2009-10-21 2010-10-21 Autoinjector

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP10781990.6A Division EP2490735B1 (en) 2009-10-21 2010-10-21 Autoinjector

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP18166692.6A Division EP3366337A3 (en) 2009-10-21 2010-10-21 Autoinjector

Publications (3)

Publication Number Publication Date
EP3000498A2 EP3000498A2 (en) 2016-03-30
EP3000498A3 EP3000498A3 (en) 2016-06-22
EP3000498B1 true EP3000498B1 (en) 2018-04-11

Family

ID=43805716

Family Applications (3)

Application Number Title Priority Date Filing Date
EP15184955.1A Active EP3000498B1 (en) 2009-10-21 2010-10-21 Autoinjector
EP18166692.6A Pending EP3366337A3 (en) 2009-10-21 2010-10-21 Autoinjector
EP10781990.6A Active EP2490735B1 (en) 2009-10-21 2010-10-21 Autoinjector

Family Applications After (2)

Application Number Title Priority Date Filing Date
EP18166692.6A Pending EP3366337A3 (en) 2009-10-21 2010-10-21 Autoinjector
EP10781990.6A Active EP2490735B1 (en) 2009-10-21 2010-10-21 Autoinjector

Country Status (8)

Country Link
US (2) US8915886B2 (en)
EP (3) EP3000498B1 (en)
JP (2) JP5763654B2 (en)
KR (1) KR101746881B1 (en)
CN (2) CN102665800B (en)
DK (1) DK2490735T3 (en)
RU (1) RU2565388C2 (en)
WO (1) WO2011048422A2 (en)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60323729D1 (en) 2002-02-11 2008-11-06 Antares Pharma Inc Intradermal injection device
DK1850892T3 (en) 2005-01-24 2019-04-15 Antares Pharma Inc Pre-filled needle-assisted syringe injector
WO2007131013A1 (en) 2006-05-03 2007-11-15 Antares Pharma, Inc. Two-stage reconstituting injector
WO2007131025A1 (en) 2006-05-03 2007-11-15 Antares Pharma, Inc. Injector with adjustable dosing
ES2548447T3 (en) 2008-03-10 2015-10-16 Antares Pharma, Inc. Injector safety device
GB2460398A (en) * 2008-05-20 2009-12-02 Owen Mumford Ltd Auto-injector having a magnetic injection indicator and a needle sheath retainer
JP5611208B2 (en) 2008-08-05 2014-10-22 アンタレス・ファーマ・インコーポレーテッド Multiple dose injection device
WO2010108116A1 (en) 2009-03-20 2010-09-23 Antares Pharma, Inc. Hazardous agent injection system
GB201017363D0 (en) 2010-10-14 2010-11-24 Owen Mumford Ltd Injection devices
GB201020475D0 (en) * 2010-12-02 2011-01-19 Oval Medical Technologies Ltd Delivery mechanism for an autoinjector
EP2468336A1 (en) * 2010-12-21 2012-06-27 Sanofi-Aventis Deutschland GmbH Auto-injector
US8496619B2 (en) 2011-07-15 2013-07-30 Antares Pharma, Inc. Injection device with cammed ram assembly
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
US8808244B2 (en) * 2011-08-24 2014-08-19 Unitract Syringe Pty Ltd Auto-injector for retractable prefilled syringe
MX2014002290A (en) * 2011-08-26 2014-06-04 Lilly Co Eli Refill module for an injection device.
EP2572741A1 (en) * 2011-09-23 2013-03-27 Sanofi-Aventis Deutschland GmbH Medicament delivery device and actuation mechanism for a drug delivery device
WO2013134244A2 (en) 2012-03-06 2013-09-12 Antares Pharma, Inc. Prefilled syringe with breakaway force feature
CA2868500A1 (en) 2012-04-06 2013-10-10 Antares Pharma, Inc. Needle assisted jet injection administration of testosterone compositions
WO2013169804A1 (en) 2012-05-07 2013-11-14 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
CN104394911B (en) 2012-05-25 2017-03-01 阿普塔尔法国简易股份公司 Automatic injector
EP2854901B1 (en) 2012-05-25 2019-10-02 Aptar France SAS Autoinjector comprising a time delay device having a planetary gear set for delaying the retraction of the needle
EP2854903B1 (en) 2012-05-25 2019-10-23 Aptar France SAS Autoinjector
WO2013175144A1 (en) 2012-05-25 2013-11-28 Aptar France Sas Autoinjector
FR2990868B1 (en) * 2012-05-25 2015-10-02 Aptar France Sas Autoinjector
FR2990864B1 (en) * 2012-05-25 2015-05-15 Valois Sas Autoinjector
US9931467B2 (en) 2012-05-25 2018-04-03 Aptar France Sas Autoinjector
JP6196311B2 (en) 2012-09-27 2017-09-13 アプター フランス エスアーエス Self-injector
US9872961B2 (en) 2012-10-19 2018-01-23 Eli Lilly And Company Automatic injection device with trigger assembly
EP2752211A1 (en) * 2013-01-07 2014-07-09 F. Hoffmann-La Roche Ltd. Safety device for an injection syringue
JP2016507305A (en) 2013-02-11 2016-03-10 アンタレス・ファーマ・インコーポレーテッド Needle-assisted jet injection device with reduced trigger force
US9707354B2 (en) 2013-03-11 2017-07-18 Antares Pharma, Inc. Multiple dosage injector with rack and pinion dosage system
WO2014165136A1 (en) 2013-03-12 2014-10-09 Antares Pharma, Inc. Constant volume prefilled syringes and kits thereof
WO2014174519A1 (en) 2013-04-23 2014-10-30 Elcam Medical Agricultural Cooperative Association Ltd. Automatic injection device for administration of high viscosity medication
ES2688320T3 (en) * 2013-05-24 2018-10-31 Becton Dickinson France Automatic injection device
AT514484B1 (en) * 2013-06-24 2015-05-15 Pharma Consult Gmbh Activator for an auto-injector
FR3007989B1 (en) * 2013-07-05 2016-01-01 Aptar France Sas Autoinjector.
EP3060278A1 (en) * 2013-10-18 2016-08-31 Sanofi-Aventis Deutschland GmbH Medicament delivery device with two drive springs
TWI569832B (en) * 2013-10-23 2017-02-11 卡貝歐洲有限公司 Medicament delivery device
MX2016006213A (en) * 2013-11-13 2016-08-08 Genentech Inc Assisted manual injector devices and methods.
WO2015138261A1 (en) * 2014-03-12 2015-09-17 Min Wei Automatic medication injection device
WO2015160600A1 (en) * 2014-04-15 2015-10-22 Min Wei Medication delivery device
CN104337523B (en) * 2014-10-24 2016-06-01 吴燕霞 Automatically suction syringe
CN107029317A (en) * 2015-07-31 2017-08-11 贺小军 Cartridge syringe
KR101705050B1 (en) * 2015-10-15 2017-02-09 (주)풍림파마텍 Automatic injecting apparatus for filler
CN105413023A (en) * 2016-01-04 2016-03-23 苏州肯美威机械制造有限公司 Needless injector
GB2560554A (en) * 2017-03-15 2018-09-19 Owen Mumford Ltd Injection device with gap reduction mechanism

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE755224A (en) 1969-08-25 1971-02-24 Philips Nv Injection syringe
JPS5995054A (en) 1982-11-22 1984-05-31 Biruherumu Haazerumaiyaa Gmbh Syringe
GB8926825D0 (en) * 1989-11-28 1990-01-17 Glaxo Group Ltd Device
GB9200219D0 (en) 1992-01-07 1992-02-26 Medimech Int Ltd Automatic injectors
SE9803662D0 (en) * 1998-10-26 1998-10-26 Pharmacia & Upjohn Ab autoinjector
DE10342059B4 (en) * 2003-09-11 2007-03-01 Tecpharma Licensing Ag Delivery device with piercing and Ausschutinrichtung
GB2414401B (en) * 2004-05-28 2009-06-17 Cilag Ag Int Injection device
FR2884721A1 (en) 2005-04-20 2006-10-27 Becton Dickinson France Soc Pa Assistance device for device of injection of a product, comprises hollow body for receiving the product, hollow injection needle for penetrating into injection site, piston placed in the body, hollow sleeve with bearing surface
JP2008543500A (en) * 2005-06-21 2008-12-04 イーライ リリー アンド カンパニー Instruments and methods for pharmaceutical injection
US20110098656A1 (en) * 2005-09-27 2011-04-28 Burnell Rosie L Auto-injection device with needle protecting cap having outer and inner sleeves
FR2905273B1 (en) * 2006-09-06 2009-04-03 Becton Dickinson France Soc Pa Automatic injection device with timing means.
DE102007013836A1 (en) * 2007-03-22 2008-09-25 Tecpharma Licensing Ag Injection device with controlled needle retraction
JP4992147B2 (en) * 2007-07-06 2012-08-08 エス・ホー・エル・グループ・アクチボラゲットShl Group Ab One shot syringe with double spring
EP2237817B1 (en) * 2007-11-14 2019-02-13 SHL Group AB Automatic injection device with actively triggered syringe withdrawal

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
None *

Also Published As

Publication number Publication date
US9707344B2 (en) 2017-07-18
KR20120099022A (en) 2012-09-06
CN104689426A (en) 2015-06-10
KR101746881B1 (en) 2017-06-14
EP2490735B1 (en) 2015-09-16
EP3000498A3 (en) 2016-06-22
JP6110433B2 (en) 2017-04-05
EP3000498A2 (en) 2016-03-30
JP5763654B2 (en) 2015-08-12
WO2011048422A3 (en) 2011-09-22
CN102665800B (en) 2015-02-18
EP2490735A2 (en) 2012-08-29
US20120220954A1 (en) 2012-08-30
DK2490735T3 (en) 2016-01-11
US8915886B2 (en) 2014-12-23
RU2012120309A (en) 2013-11-27
EP3366337A2 (en) 2018-08-29
EP3366337A3 (en) 2018-11-14
WO2011048422A2 (en) 2011-04-28
CN102665800A (en) 2012-09-12
JP2015157218A (en) 2015-09-03
US20150100031A1 (en) 2015-04-09
CN104689426B (en) 2018-10-02
JP2013508054A (en) 2013-03-07
RU2565388C2 (en) 2015-10-20

Similar Documents

Publication Publication Date Title
US8277412B2 (en) One shot injector with dual springs
EP1755709B1 (en) Injection device
KR101205804B1 (en) Injection device
RU2486923C2 (en) Injection device
US7717874B2 (en) Needle-free injection system
US7322997B2 (en) Automatic safe disposable blood sampling device of casing self-locking type
EP1485153B1 (en) Needle protection device for a syringe and an injection device comprising a syringe and said protection device
CA2440898C (en) Improved non-reusable syringe
CA2568655C (en) Injection device
EP2620174B1 (en) Substance delivery device
EP2131898B1 (en) Auto injector
CA2653311C (en) Injection device with syringe carrier engagement with cap
US4407283A (en) Self-injecting syringe
AU2004286735B2 (en) Autoinjection device
EP1567212B1 (en) One-use retracting syringe with positive needle retention
AU2005256832B2 (en) Improvements relating to automatic injection devices
DK2326368T3 (en) Automatic injection device with shutter lock
ES2349667T3 (en) Automatic injectors
CA2568684C (en) Injection device
EP1932558A1 (en) Auto-Injector
AU2002251342B2 (en) Improvements relating to syringe holders
US5865795A (en) Safety mechanism for injection devices
AU2006310971B2 (en) Autoinjector activation triggering element
DE60223045T2 (en) Shield for lace
DE69839283T2 (en) Injection device

Legal Events

Date Code Title Description
AC Divisional application: reference to earlier application

Ref document number: 2490735

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

17P Request for examination filed

Effective date: 20151009

RIC1 Information provided on ipc code assigned before grant

Ipc: A61M 5/20 20060101AFI20160519BHEP

Ipc: A61M 5/315 20060101ALI20160519BHEP

Ipc: A61M 5/32 20060101ALI20160519BHEP

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

INTG Intention to grant announced

Effective date: 20171027

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AC Divisional application: reference to earlier application

Ref document number: 2490735

Country of ref document: EP

Kind code of ref document: P

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

Ref country code: CH

Ref legal event code: NV

Representative=s name: CRONIN INTELLECTUAL PROPERTY, CH

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 987322

Country of ref document: AT

Kind code of ref document: T

Effective date: 20180415

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602010049939

Country of ref document: DE

REG Reference to a national code

Ref country code: CH

Ref legal event code: PCAR

Free format text: NEW ADDRESS: CHEMIN DE LA VUARPILLIERE 29, 1260 NYON (CH)

REG Reference to a national code

Ref country code: NL

Ref legal event code: MP

Effective date: 20180411

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180411

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 9

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180711

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180711

Ref country code: AL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180411

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180411

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180411

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180411

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180411

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180411

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180411

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180411

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180712

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180411

PGFP Annual fee paid to national office [announced from national office to epo]

Ref country code: CZ

Payment date: 20180924

Year of fee payment: 9

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 987322

Country of ref document: AT

Kind code of ref document: T

Effective date: 20180411

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180813

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602010049939

Country of ref document: DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180411

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180411

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180411

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180411

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180411

PGFP Annual fee paid to national office [announced from national office to epo]

Ref country code: DE

Payment date: 20181010

Year of fee payment: 9

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180411

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180411

PGFP Annual fee paid to national office [announced from national office to epo]

Ref country code: FR

Payment date: 20181015

Year of fee payment: 9

Ref country code: GB

Payment date: 20181011

Year of fee payment: 9

Ref country code: CH

Payment date: 20181022

Year of fee payment: 9

26N No opposition filed

Effective date: 20190114

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180411

REG Reference to a national code

Ref country code: BE

Ref legal event code: MM

Effective date: 20181031

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20180411

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20181021

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20181031

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20181021