|
EP2655409A4
(en)
|
2010-12-22 |
2015-07-01 |
Univ Leland Stanford Junior |
SUPERAGONISTS AND ANTAGONISTS OF INTERLEUKIN-2
|
|
EP2855666B1
(en)
*
|
2012-05-25 |
2019-12-04 |
Cellectis |
Use of pre t alpha or functional variant thereof for expanding tcr alpha deficient t cells
|
|
ES2776698T3
(es)
|
2012-12-20 |
2020-07-31 |
Purdue Research Foundation |
Células T que expresan un receptor antigénico quimérico como terapia contra el cáncer
|
|
WO2014117121A1
(en)
|
2013-01-28 |
2014-07-31 |
St. Jude Children's Research Hospital, Inc. |
A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease
|
|
PL3300745T3
(pl)
|
2013-02-15 |
2020-03-31 |
The Regents Of The University Of California |
Chimeryczny receptor antygenowy i sposoby jego zastosowania
|
|
SG11201506974XA
(en)
|
2013-03-14 |
2015-10-29 |
Bellicum Pharmaceuticals Inc |
Methods for controlling t cell proliferation
|
|
EP2970426B1
(en)
|
2013-03-15 |
2019-08-28 |
Michael C. Milone |
Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
|
|
WO2015017214A1
(en)
*
|
2013-07-29 |
2015-02-05 |
Bluebird Bio, Inc. |
Multipartite signaling proteins and uses thereof
|
|
CN105722860A
(zh)
|
2013-09-24 |
2016-06-29 |
梅迪塞纳医疗股份有限公司 |
白介素-2融合蛋白及其应用
|
|
CN106029696B
(zh)
|
2013-12-17 |
2020-07-28 |
基因泰克公司 |
抗cd3抗体及使用方法
|
|
EP3087101B1
(en)
|
2013-12-20 |
2024-06-05 |
Novartis AG |
Regulatable chimeric antigen receptor
|
|
EP3094354B1
(en)
|
2014-01-14 |
2018-10-17 |
Cellectis |
Chimeric antigen receptor using antigen recognition domains derived from cartilaginous fish
|
|
CN106132423B
(zh)
|
2014-02-14 |
2020-07-31 |
贝里坤制药股份有限公司 |
用诱导型嵌合多肽活化t细胞的方法
|
|
WO2015142661A1
(en)
|
2014-03-15 |
2015-09-24 |
Novartis Ag |
Regulatable chimeric antigen receptor
|
|
GB201405845D0
(en)
|
2014-04-01 |
2014-05-14 |
Ucl Business Plc |
Signalling system
|
|
ES2876263T3
(es)
|
2014-04-07 |
2021-11-12 |
Novartis Ag |
Tratamiento del cáncer usando receptor de antígeno quimérico anti-cd19
|
|
RU2763795C2
(ru)
|
2014-04-23 |
2022-01-11 |
Джуно Терапьютикс, Инк. |
Способы выделения, культивирования и генетической инженерии популяций клеток иммунной системы для адоптивной терапии
|
|
CN106659757B
(zh)
|
2014-04-24 |
2022-01-28 |
利兰斯坦福初级大学董事会 |
白介素2的超级激动剂、部分激动剂和拮抗剂
|
|
CA2948462A1
(en)
|
2014-05-15 |
2015-11-19 |
National University Of Singapore |
Modified natural killer cells and uses thereof
|
|
AU2015269219B2
(en)
*
|
2014-06-06 |
2020-12-24 |
Memorial Sloan-Kettering Cancer Center |
Mesothelin-targeted chimeric antigen receptors and uses thereof
|
|
EP3193915A1
(en)
|
2014-07-21 |
2017-07-26 |
Novartis AG |
Combinations of low, immune enhancing. doses of mtor inhibitors and cars
|
|
US10174095B2
(en)
|
2014-07-21 |
2019-01-08 |
Novartis Ag |
Nucleic acid encoding a humanized anti-BCMA chimeric antigen receptor
|
|
US11542488B2
(en)
|
2014-07-21 |
2023-01-03 |
Novartis Ag |
Sortase synthesized chimeric antigen receptors
|
|
EP3174546B1
(en)
|
2014-07-31 |
2019-10-30 |
Novartis AG |
Subset-optimized chimeric antigen receptor-containing t-cells
|
|
US11111288B2
(en)
|
2014-08-28 |
2021-09-07 |
Bioatla, Inc. |
Conditionally active chimeric antigen receptors for modified t-cells
|
|
KR102615681B1
(ko)
|
2014-08-28 |
2023-12-18 |
바이오아트라, 인코퍼레이티드 |
변형된 t 세포에 대한 조건부 활성 키메라 항원 수용체
|
|
GB201415347D0
(en)
*
|
2014-08-29 |
2014-10-15 |
Ucl Business Plc |
Signalling system
|
|
ES2688035T3
(es)
|
2014-08-29 |
2018-10-30 |
Gemoab Monoclonals Gmbh |
Receptor de antígeno universal que expresa células inmunes para direccionamiento de antígenos múltiples diversos, procedimiento para fabricación del mismo y utilización del mismo para tratamiento de cáncer, infecciones y enfermedades autoinmunes
|
|
EP3189148A4
(en)
|
2014-09-02 |
2018-05-02 |
Bellicum Pharmaceuticals, Inc. |
Costimulation of chimeric antigen receptors by myd88 and cd40 polypeptides
|
|
DK3189073T4
(da)
|
2014-09-04 |
2025-08-18 |
Cellectis |
Trofoblastglykoprotein (5t4, tpbg)-specifikke kimære antigenreceptorer til cancerimmunterapi
|
|
KR20210149228A
(ko)
|
2014-09-17 |
2021-12-08 |
노파르티스 아게 |
입양 면역요법을 위한 키메라 수용체에 의한 세포독성 세포의 표적화
|
|
US20170218036A1
(en)
*
|
2014-10-03 |
2017-08-03 |
Yale University |
Innate immune system modification for anticancer therapy
|
|
CA2963327A1
(en)
*
|
2014-10-07 |
2016-04-14 |
Cellectis |
Method for modulating car-induced immune cells activity
|
|
US10774388B2
(en)
|
2014-10-08 |
2020-09-15 |
Novartis Ag |
Biomarkers predictive of therapeutic responsiveness to chimeric antigen receptor therapy and uses thereof
|
|
EP3025719B1
(en)
|
2014-11-26 |
2018-09-26 |
Miltenyi Biotec GmbH |
Combination immunotherapy of antigen-recognizing receptors and hematopoietic cells for the treatment of diseases
|
|
SG11201704519YA
(en)
*
|
2014-12-02 |
2017-07-28 |
Roger Williams Hospital |
Methods and compositons for treating cancer
|
|
RU2725819C2
(ru)
|
2014-12-05 |
2020-07-06 |
Мемориал Слоан-Кеттеринг Кэнсер Сентер |
Антитела, нацеленные на рецептор, связанный с g-белками, и способы их применения
|
|
SI3227339T1
(sl)
|
2014-12-05 |
2022-02-28 |
Memorial Sloan-Kettering Cancer Center |
Himerni antigenski receptorji, ki ciljajo na receptor, povezan z G-proteinom, in njihova uporaba
|
|
WO2016094783A1
(en)
|
2014-12-12 |
2016-06-16 |
Voyager Therapeutics, Inc. |
Compositions and methods for the production of scaav
|
|
EP4400516A1
(en)
|
2014-12-15 |
2024-07-17 |
The Regents of the University of California |
Bispecific or-gate chimeric antigen receptor responsive to cd19 and cd20
|
|
CA2966241A1
(en)
*
|
2014-12-15 |
2016-06-23 |
Bellicum Pharmaceuticals, Inc. |
Methods for controlled activation or elimination of therapeutic cells
|
|
DK3233903T3
(da)
*
|
2014-12-19 |
2021-02-22 |
Eth Zuerich |
Kimære antigenreceptorer og anvendelsesfremgangsmåder
|
|
WO2016098078A2
(en)
*
|
2014-12-19 |
2016-06-23 |
Novartis Ag |
Dimerization switches and uses thereof
|
|
HUE046054T2
(hu)
|
2014-12-24 |
2020-01-28 |
Aadigen Llc |
Peptidek és nanorészecskék molekulák intracelluláris célba juttatásához
|
|
RU2751362C2
(ru)
|
2014-12-29 |
2021-07-13 |
Новартис Аг |
Способы получения экспрессирующих химерный антигенный рецептор клеток
|
|
GB201501936D0
(en)
|
2015-02-05 |
2015-03-25 |
Ucl Business Plc |
Signalling system
|
|
GB201503133D0
(en)
|
2015-02-24 |
2015-04-08 |
Ucl Business Plc And Syncona Partners Llp |
Chimeric protein
|
|
IL254141B
(en)
|
2015-02-27 |
2022-07-01 |
Icell Gene Therapeutics Llc |
Chimeric antigen receptors (cars) focusing on hematological malignancies, preparations and methods for their use
|
|
US10195272B2
(en)
|
2015-03-02 |
2019-02-05 |
The Nemours Foundation |
Adoptive t-cell therapy using FcεRI-based chimeric antigen receptors for treating IgE-mediated allergic diseases
|
|
GB201504840D0
(en)
*
|
2015-03-23 |
2015-05-06 |
Ucl Business Plc |
Chimeric antigen receptor
|
|
JP6890546B2
(ja)
*
|
2015-04-02 |
2021-06-18 |
メモリアル スローン ケタリング キャンサー センター |
Tnfrsf14/hvemタンパク質およびその使用の方法
|
|
HUE059218T2
(hu)
|
2015-04-08 |
2022-11-28 |
Novartis Ag |
CD20-terápiák, CD22-terápiák és kombinációs terápiák CD19 kiméra antigénreceptort (CAR-t) expresszáló sejttel
|
|
EP3283113A4
(en)
*
|
2015-04-15 |
2018-12-05 |
The California Institute for Biomedical Research |
Optimized pne-based chimeric receptor t cell switches and uses thereof
|
|
US11896614B2
(en)
|
2015-04-17 |
2024-02-13 |
Novartis Ag |
Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells
|
|
GB201507115D0
(en)
*
|
2015-04-27 |
2015-06-10 |
Ucl Business Plc |
Nucleic Acid Construct
|
|
GB201507119D0
(en)
*
|
2015-04-27 |
2015-06-10 |
Ucl Business Plc |
Nucleic Acid Construct
|
|
GB201507111D0
(en)
*
|
2015-04-27 |
2015-06-10 |
Ucl Business Plc |
Nucleic acid construct
|
|
FI3447075T3
(fi)
|
2015-05-15 |
2023-11-07 |
Massachusetts Gen Hospital |
Antagonistisia anti-tuumorinekroositekijäreseptorin superperheen vasta-aineita
|
|
CN114634943A
(zh)
|
2015-05-18 |
2022-06-17 |
T细胞受体治疗公司 |
使用融合蛋白对tcr重编程的组合物和方法
|
|
TW202444897A
(zh)
|
2015-06-25 |
2024-11-16 |
美商生物細胞基因治療有限公司 |
嵌合抗原受體(car)、組合物及其使用方法
|
|
US11173179B2
(en)
|
2015-06-25 |
2021-11-16 |
Icell Gene Therapeutics Llc |
Chimeric antigen receptor (CAR) targeting multiple antigens, compositions and methods of use thereof
|
|
SG10201912978PA
(en)
*
|
2015-07-21 |
2020-02-27 |
Novartis Ag |
Methods for improving the efficacy and expansion of immune cells
|
|
GB201513540D0
(en)
|
2015-07-31 |
2015-09-16 |
King S College London |
Therapeutic agents
|
|
US10975148B2
(en)
|
2015-08-05 |
2021-04-13 |
CellabMED Inc. |
Chimeric antigen receptors, and T cells in which chimeric antigen receptor is expressed
|
|
WO2017024318A1
(en)
|
2015-08-06 |
2017-02-09 |
Dana-Farber Cancer Institute, Inc. |
Targeted protein degradation to attenuate adoptive t-cell therapy associated adverse inflammatory responses
|
|
WO2017027392A1
(en)
*
|
2015-08-07 |
2017-02-16 |
Novartis Ag |
Treatment of cancer using chimeric cd3 receptor proteins
|
|
KR20180042361A
(ko)
|
2015-08-24 |
2018-04-25 |
셀렉티스 |
통합된 통제가능한 기능들을 가진 키메라 항원 수용체들
|
|
IL293963A
(en)
|
2015-09-01 |
2022-08-01 |
Univ California |
Modular polypeptide libraries and methods of making and using same
|
|
CN108780084B
(zh)
|
2015-09-03 |
2022-07-22 |
诺华股份有限公司 |
预测细胞因子释放综合征的生物标志物
|
|
EP3352784A4
(en)
|
2015-09-23 |
2019-06-26 |
Cytoimmune Therapeutics, LLC |
FLT3-FACED CAR CELLS FOR IMMUNOTHERAPY
|
|
US12241053B2
(en)
|
2015-10-09 |
2025-03-04 |
The Brigham And Women's Hospital, Inc. |
Modulation of novel immune checkpoint targets
|
|
WO2017075465A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3
|
|
WO2017075451A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1
|
|
WO2017087708A1
(en)
|
2015-11-19 |
2017-05-26 |
The Brigham And Women's Hospital, Inc. |
Lymphocyte antigen cd5-like (cd5l)-interleukin 12b (p40) heterodimers in immunity
|
|
US20210206826A1
(en)
*
|
2015-11-19 |
2021-07-08 |
The Regents Of The University Of California |
Conditionally repressible immune cell receptors and methods of use thereof
|
|
EP3380602A4
(en)
|
2015-11-23 |
2019-09-25 |
Trustees of Boston University |
METHOD AND COMPOSITIONS RELATED TO CHIMERIC ANTIGEN RECEPTORS
|
|
EP3389630B1
(en)
|
2015-12-16 |
2023-11-08 |
Gritstone bio, Inc. |
Neoantigen identification, manufacture, and use
|
|
EP3184548A1
(en)
|
2015-12-23 |
2017-06-28 |
Miltenyi Biotec GmbH |
Chimeric antigen receptor with cytokine receptor activating or blocking domain
|
|
US20190269727A1
(en)
|
2015-12-28 |
2019-09-05 |
Novartis Ag |
Methods of making chimeric antigen receptor-expressing cells
|
|
SG10201913805RA
(en)
*
|
2016-01-08 |
2020-03-30 |
Univ California |
Conditionally active heterodimeric polypeptides and methods of use thereof
|
|
KR102808969B1
(ko)
|
2016-01-11 |
2025-05-15 |
더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 |
키메라 단백질 및 면역요법 방법
|
|
SG11201805792PA
(en)
|
2016-01-11 |
2018-08-30 |
Univ Leland Stanford Junior |
Chimeric proteins and methods of regulating gene expression
|
|
CN105567640A
(zh)
*
|
2016-01-27 |
2016-05-11 |
苏州佰通生物科技有限公司 |
一种嵌合抗原受体脂肪干细胞及其制备方法
|
|
GB201602571D0
(en)
*
|
2016-02-12 |
2016-03-30 |
Autolus Ltd |
Signalling system
|
|
GB201602563D0
(en)
*
|
2016-02-12 |
2016-03-30 |
Autolus Ltd |
Signalling system
|
|
US10871490B2
(en)
|
2016-02-29 |
2020-12-22 |
Multenyi Biotec, gmbH |
Assay for detection of chimeric antigen receptor T cells
|
|
EP3436070A4
(en)
*
|
2016-03-29 |
2019-11-27 |
University of Southern California |
AGAINST CANCER, CHIMERIC ANTIGEN RECEPTORS
|
|
AU2017240233B2
(en)
*
|
2016-03-31 |
2022-07-14 |
University Of Southern California |
A highly sensitive and specific luciferase based reporter assay for antigen detection
|
|
US20190183931A1
(en)
|
2016-04-01 |
2019-06-20 |
Amgen Inc. |
Chimeric receptors to flt3 and methods of use thereof
|
|
PE20190356A1
(es)
|
2016-04-01 |
2019-03-07 |
Kite Pharma Inc |
Receptores quimericos y metodos de uso de los mismos
|
|
KR102427334B1
(ko)
|
2016-04-01 |
2022-08-03 |
카이트 파마 인코포레이티드 |
키메라 항원 및 t 세포 수용체 및 사용 방법
|
|
AU2017240150C1
(en)
|
2016-04-01 |
2022-10-27 |
Kite Pharma, Inc. |
BCMA binding molecules and methods of use thereof
|
|
JP7282521B2
(ja)
|
2016-04-08 |
2023-05-29 |
パーデュー・リサーチ・ファウンデイション |
Car t細胞療法のための方法および組成物
|
|
EP3443001B1
(en)
|
2016-04-11 |
2025-04-30 |
Obsidian Therapeutics, Inc. |
REGULATED BIOCIRCUIT SYSTEMS
|
|
CN109311963A
(zh)
*
|
2016-04-14 |
2019-02-05 |
蓝鸟生物公司 |
救助嵌合抗原受体系统
|
|
EP4628587A2
(en)
|
2016-04-15 |
2025-10-08 |
Memorial Sloan Kettering Cancer Center |
Transgenic t cell and chimeric antigen receptor t cell compositions and related methods
|
|
LT3455261T
(lt)
|
2016-05-13 |
2022-11-10 |
Bioatla, Inc. |
Antikūnai prieš ror2, antikūnų fragmentai, jų imunokonjugatai ir panaudojimas
|
|
WO2017210617A2
(en)
|
2016-06-02 |
2017-12-07 |
Porter, David, L. |
Therapeutic regimens for chimeric antigen receptor (car)- expressing cells
|
|
US20200283534A1
(en)
|
2016-06-24 |
2020-09-10 |
iCell Gene Therapeuticics LLC |
CHIMERIC ANTIGEN RECEPTORS (CARs), COMPOSITIONS AND METHODS THEREOF
|
|
US11384156B2
(en)
|
2016-07-25 |
2022-07-12 |
The Nemours Foundation |
Adoptive T-cell therapy using EMPD-specific chimeric antigen receptors for treating IgE-mediated allergic diseases
|
|
EP3494138A1
(en)
|
2016-08-02 |
2019-06-12 |
TCR2 Therapeutics Inc. |
Compositions and methods for tcr reprogramming using fusion proteins
|
|
EP3344263A4
(en)
|
2016-08-04 |
2020-07-01 |
Memorial Sloan-Kettering Cancer Center |
CANCER ANTIGEN TARGETS AND USES THEREOF
|
|
CN109789164B
(zh)
*
|
2016-08-30 |
2023-04-28 |
亘喜生物科技(上海)有限公司 |
具有gitr胞内结构域作为共刺激结构域的嵌合抗原受体
|
|
US20180064758A1
(en)
*
|
2016-09-05 |
2018-03-08 |
Ucl Business Plc |
Chimeric antigen receptor
|
|
CN107793483B
(zh)
*
|
2016-09-06 |
2019-08-23 |
伍志强 |
嵌合抗原受体及其基因和重组表达载体、carmsln-nkt细胞及其制备方法和应用
|
|
WO2018049025A2
(en)
|
2016-09-07 |
2018-03-15 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses
|
|
JP6698854B2
(ja)
*
|
2016-09-16 |
2020-05-27 |
キッセイ薬品工業株式会社 |
遺伝子改変細胞及びその作製方法
|
|
ES2811500T3
(es)
*
|
2016-10-04 |
2021-03-12 |
Prec Biosciences Inc |
Dominios coestimuladores para su uso en células genéticamente modificadas
|
|
WO2018067991A1
(en)
|
2016-10-07 |
2018-04-12 |
The Brigham And Women's Hospital, Inc. |
Modulation of novel immune checkpoint targets
|
|
GB2564823B8
(en)
|
2016-10-07 |
2022-06-29 |
Tcr2 Therapeutics Inc |
Compositions and methods for TCR reprogramming using fusion proteins
|
|
CA3039646A1
(en)
|
2016-10-07 |
2018-04-12 |
Novartis Ag |
Chimeric antigen receptors for the treatment of cancer
|
|
JP7100028B2
(ja)
*
|
2016-10-20 |
2022-07-12 |
セルジーン コーポレイション |
セレブロン系のヘテロ二量体化可能なキメラ抗原受容体
|
|
WO2018089386A1
(en)
|
2016-11-11 |
2018-05-17 |
The Broad Institute, Inc. |
Modulation of intestinal epithelial cell differentiation, maintenance and/or function through t cell action
|
|
CA3044593A1
(en)
|
2016-11-22 |
2018-05-31 |
TCR2 Therapeutics Inc. |
Compositions and methods for tcr reprogramming using fusion proteins
|
|
CN107058315B
(zh)
*
|
2016-12-08 |
2019-11-08 |
上海优卡迪生物医药科技有限公司 |
敲减人PD-1的siRNA、重组表达CAR-T载体及其构建方法和应用
|
|
US11753460B2
(en)
|
2016-12-13 |
2023-09-12 |
Seattle Children's Hospital |
Methods of exogenous drug activation of chemical-induced signaling complexes expressed in engineered cells in vitro and in vivo
|
|
US20200095301A1
(en)
|
2016-12-14 |
2020-03-26 |
The Board Of Trustees Of The Leland Stanford Junior University |
Il-13 superkine: immune cell targeting constructs and methods of use thereof
|
|
EP3568406A4
(en)
|
2017-01-10 |
2020-10-21 |
The General Hospital Corporation |
T LYMPHOCYTES EXPRESSING A CHEMERICAL ANTIGENIC RECEPTOR
|
|
CN107573419A
(zh)
*
|
2017-01-24 |
2018-01-12 |
深圳市体内生物医药科技有限公司 |
一种增强t细胞抗肿瘤活性的核酸分子
|
|
US11649288B2
(en)
|
2017-02-07 |
2023-05-16 |
Seattle Children's Hospital |
Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents
|
|
EP4119552A1
(en)
*
|
2017-02-08 |
2023-01-18 |
Dana-Farber Cancer Institute, Inc. |
Regulating chimeric antigen receptors
|
|
WO2018160622A1
(en)
|
2017-02-28 |
2018-09-07 |
Endocyte, Inc. |
Compositions and methods for car t cell therapy
|
|
CA3055202A1
(en)
*
|
2017-03-03 |
2018-09-07 |
Obsidian Therapeutics, Inc. |
Cd19 compositions and methods for immunotherapy
|
|
US20180280437A1
(en)
|
2017-03-13 |
2018-10-04 |
Kite Pharma, Inc. |
Chimeric antigen receptors for melanoma and uses thereof
|
|
KR102624509B1
(ko)
|
2017-03-27 |
2024-01-12 |
싱가포르국립대학교 |
자연 살해 세포의 ex vivo 확장 및 활성화를 위한 자극성 세포주
|
|
EP3600356A4
(en)
|
2017-03-27 |
2020-12-23 |
National University of Singapore |
TRUNCATED NKG2D CHEMERIC RECEPTORS AND THEIR USES IN NATURAL KILLER CELL IMMUNOTHERAPY
|
|
JOP20180027A1
(ar)
|
2017-03-28 |
2019-01-30 |
Cell Design Labs Inc |
بوليبيبتيدات مخلطة و طرق لتغيير موضع الغشاء فيها
|
|
CA3057505A1
(en)
*
|
2017-03-31 |
2018-10-04 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods of treating t cell exhaustion by inhibiting or modulating t cell receptor signaling
|
|
WO2018183908A1
(en)
|
2017-03-31 |
2018-10-04 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for treating ovarian tumors
|
|
WO2018183921A1
(en)
|
2017-04-01 |
2018-10-04 |
The Broad Institute, Inc. |
Methods and compositions for detecting and modulating an immunotherapy resistance gene signature in cancer
|
|
US20200071773A1
(en)
|
2017-04-12 |
2020-03-05 |
Massachusetts Eye And Ear Infirmary |
Tumor signature for metastasis, compositions of matter methods of use thereof
|
|
AU2018256436B2
(en)
|
2017-04-19 |
2024-12-05 |
Board Of Regents, The University Of Texas System |
Immune cells expressing engineered antigen receptors
|
|
JOP20180042A1
(ar)
|
2017-04-24 |
2019-01-30 |
Kite Pharma Inc |
نطاقات ربط مولد ضد متوافقة مع البشر وطرق الاستخدام
|
|
WO2018209324A2
(en)
|
2017-05-11 |
2018-11-15 |
The Broad Institute, Inc. |
Methods and compositions of use of cd8+ tumor infiltrating lymphocyte subtypes and gene signatures thereof
|
|
EP3606950A1
(en)
*
|
2017-05-12 |
2020-02-12 |
Cellectis |
Protease based switch chimeric antigen receptors for safer cell immunotherapy
|
|
CN110621694A
(zh)
*
|
2017-05-15 |
2019-12-27 |
奥托路斯有限公司 |
包含嵌合抗原受体(car)的细胞
|
|
CN107141356B
(zh)
*
|
2017-06-07 |
2020-03-13 |
胜武(北京)生物科技有限公司 |
一种光诱导二聚体型嵌合抗原受体
|
|
US11897953B2
(en)
|
2017-06-14 |
2024-02-13 |
The Broad Institute, Inc. |
Compositions and methods targeting complement component 3 for inhibiting tumor growth
|
|
US11542312B2
(en)
|
2017-06-19 |
2023-01-03 |
Medicenna Therapeutics, Inc. |
IL-2 superagonists in combination with anti-PD-1 antibodies
|
|
US11325957B2
(en)
|
2017-06-19 |
2022-05-10 |
Cell Design Labs, Inc. |
Methods and compositions for reducing the immunogenicity of chimeric notch receptors
|
|
US12275787B2
(en)
|
2017-06-21 |
2025-04-15 |
Icell Gene Therapeutics Llc |
Chimeric antigen receptors (CARs), compositions and methods thereof
|
|
US12049643B2
(en)
|
2017-07-14 |
2024-07-30 |
The Broad Institute, Inc. |
Methods and compositions for modulating cytotoxic lymphocyte activity
|
|
CN107446937B
(zh)
*
|
2017-09-05 |
2020-12-25 |
深圳华云生物技术有限公司 |
嵌合抗原受体及其表达基因、光控调节的嵌合抗原受体修饰的t细胞及其应用
|
|
US12221465B2
(en)
|
2017-09-06 |
2025-02-11 |
California Institute Of Technology |
Signaling and antigen-presenting bifunctional receptors (SABR)
|
|
CN109504697A
(zh)
*
|
2017-09-15 |
2019-03-22 |
上海恒润达生生物科技有限公司 |
一种靶向人源化mesothelin的嵌合抗原受体的方法和用途
|
|
JP2021500859A
(ja)
*
|
2017-09-22 |
2021-01-14 |
エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド |
Nfkbシグナル伝達の増強を伴うキメラ抗原受容体
|
|
CN109553686A
(zh)
*
|
2017-09-26 |
2019-04-02 |
南京安吉生物科技有限公司 |
一种新型可调控的双嵌合抗原受体t细胞及其构建方法和应用
|
|
GB201715918D0
(en)
*
|
2017-09-29 |
2017-11-15 |
Tc Biopharm Ltd |
Modified CAR-T
|
|
EP3687569A1
(en)
|
2017-09-29 |
2020-08-05 |
Cell Design Labs, Inc. |
Methods of making bispecific anti-cd307e and anti-bcma chimeric antigen receptors and uses of the same
|
|
WO2019070755A1
(en)
|
2017-10-02 |
2019-04-11 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING A GENETIC SIGNATURE OF IMMUNOTHERAPY RESISTANCE IN CANCER
|
|
JP7227237B2
(ja)
|
2017-10-10 |
2023-02-21 |
グリットストーン バイオ インコーポレイテッド |
ホットスポットを利用した新生抗原の特定
|
|
WO2019084055A1
(en)
|
2017-10-23 |
2019-05-02 |
Massachusetts Institute Of Technology |
CLASSIFICATION OF GENETIC VARIATION FROM UNICELLULAR TRANSCRIPTOMS
|
|
KR20200069358A
(ko)
|
2017-10-25 |
2020-06-16 |
노파르티스 아게 |
키메라 항원 수용체 발현 세포의 제조 방법
|
|
WO2019094955A1
(en)
|
2017-11-13 |
2019-05-16 |
The Broad Institute, Inc. |
Methods and compositions for targeting developmental and oncogenic programs in h3k27m gliomas
|
|
WO2019094983A1
(en)
|
2017-11-13 |
2019-05-16 |
The Broad Institute, Inc. |
Methods and compositions for treating cancer by targeting the clec2d-klrb1 pathway
|
|
US11390655B2
(en)
|
2017-11-16 |
2022-07-19 |
Kite Pharma, Inc. |
Modified chimeric antigen receptors and methods of use
|
|
CN111630602A
(zh)
|
2017-11-22 |
2020-09-04 |
磨石肿瘤生物技术公司 |
减少新抗原的接合表位呈递
|
|
EP3724339A2
(en)
*
|
2017-12-14 |
2020-10-21 |
Celyad S.A. |
Pooling signaling and costimulatory domains in flexible car design
|
|
EP3723787A4
(en)
|
2017-12-14 |
2021-09-01 |
Bluebird Bio, Inc. |
DARIC INTERLEUKIN RECEPTORS
|
|
CN111542535A
(zh)
|
2017-12-20 |
2020-08-14 |
圣安娜儿童癌症研究中心 |
配体调控的蛋白-蛋白相互作用系统
|
|
EP3502130A1
(en)
|
2017-12-20 |
2019-06-26 |
St. Anna Kinderkrebsforschung |
Ligand regulated protein-protein interaction system
|
|
KR20250048610A
(ko)
|
2017-12-22 |
2025-04-09 |
페이트 세러퓨틱스, 인코포레이티드 |
향상된 면역 효과기 세포 및 이의 용도
|
|
WO2019126358A1
(en)
*
|
2017-12-22 |
2019-06-27 |
Cell Design Labs, Inc. |
Single- and multi-chain chimeric antigen receptors
|
|
CN111542547B
(zh)
|
2018-01-04 |
2024-02-13 |
美天施生物科技有限两合公司 |
对bdca2抗原具有特异性的嵌合抗原受体
|
|
US11994512B2
(en)
|
2018-01-04 |
2024-05-28 |
Massachusetts Institute Of Technology |
Single-cell genomic methods to generate ex vivo cell systems that recapitulate in vivo biology with improved fidelity
|
|
CN112292138A
(zh)
|
2018-01-22 |
2021-01-29 |
西雅图儿童医院(Dba西雅图儿童研究所) |
Car t细胞的使用方法
|
|
CN108017717B
(zh)
*
|
2018-01-24 |
2019-08-16 |
首都医科大学宣武医院 |
一种用于体外高效定向扩增的嵌合抗原受体及其应用
|
|
SG11202007426XA
(en)
|
2018-02-06 |
2020-09-29 |
Seattle Childrens Hospital Dba Seattle Childrens Res Inst |
Fluorescein-specific cars exhibiting optimal t cell function against fl-ple labelled tumors
|
|
CN118772288A
(zh)
|
2018-02-08 |
2024-10-15 |
豪夫迈·罗氏有限公司 |
双特异性抗原结合分子和使用方法
|
|
JP7360174B2
(ja)
|
2018-02-09 |
2023-10-12 |
ナショナル ユニヴァーシティー オブ シンガポール |
ナチュラルキラー細胞免疫療法における活性化キメラ受容体及びその使用
|
|
US20210023170A1
(en)
*
|
2018-02-12 |
2021-01-28 |
University Of Florida Research Foundation, Incorporated |
Fviii chimeric antigen receptor tregs for tolerance induction in hemophilia a
|
|
WO2019161271A1
(en)
|
2018-02-16 |
2019-08-22 |
Kite Pharma, Inc. |
Modified pluripotent stem cells and methods of making and use
|
|
EP3755349A4
(en)
|
2018-02-21 |
2021-11-17 |
Board of Regents, The University of Texas System |
PROCESS FOR ACTIVATION AND EXPANSION OF NATURAL KILLER CELLS AND THEIR USES
|
|
WO2019165237A1
(en)
|
2018-02-23 |
2019-08-29 |
Endocyte, Inc. |
Sequencing method for car t cell therapy
|
|
TW202000693A
(zh)
|
2018-02-27 |
2020-01-01 |
美商葛利史東腫瘤科技公司 |
利用泛對偶基因(pan-allele)模型之新抗原鑑別
|
|
KR20210006330A
(ko)
|
2018-03-01 |
2021-01-18 |
유니버시티 오브 캔사스 |
재조합 t 세포 수용체 유전자를 사용하여 세포-기반 치료제를 생성하는 기술
|
|
CN111742219A
(zh)
*
|
2018-03-01 |
2020-10-02 |
豪夫迈·罗氏有限公司 |
用于新颖靶抗原结合模块的特异性测定法
|
|
WO2019177986A1
(en)
*
|
2018-03-12 |
2019-09-19 |
Nantkwest, Inc. |
Use of cd33car modified high affinity nk cells (t-hank) to reduce myeloid-derived suppressor cells suppressor activity (or reduce negative impact on nk cell activity)
|
|
JP7412006B2
(ja)
*
|
2018-03-14 |
2024-01-12 |
メディジーン イミュノテラピーズ ゲーエムベーハー |
誘導性t細胞レセプター及びその使用
|
|
JP7575271B2
(ja)
|
2018-03-29 |
2024-10-29 |
フェイト セラピューティクス,インコーポレイテッド |
操作された免疫エフェクター細胞およびその使用
|
|
JP7334985B2
(ja)
|
2018-04-02 |
2023-08-29 |
ナショナル ユニヴァーシティー オブ シンガポール |
免疫細胞で発現される膜結合抗サイトカイン非シグナル伝達バインダーによるヒトサイトカインの中和
|
|
WO2019195586A1
(en)
|
2018-04-06 |
2019-10-10 |
The Regents Of The University Of California |
Methods of treating egfrviii expressing glioblastomas
|
|
WO2019195596A1
(en)
|
2018-04-06 |
2019-10-10 |
The Regents Of The University Of California |
Methods of treating glioblastomas
|
|
WO2019195576A1
(en)
*
|
2018-04-06 |
2019-10-10 |
The Regents Of The University Of California |
Trans-antigen targeting in heterogeneous cancers and methods of use thereof
|
|
KR20210018797A
(ko)
|
2018-04-10 |
2021-02-18 |
암젠 인크 |
Dll3에 대한 키메라 수용체 및 이의 사용 방법
|
|
CN108410908B
(zh)
*
|
2018-04-12 |
2021-08-03 |
吉林大学 |
一种利用植物激素ga及小分子物质pac调节细胞通路的方法
|
|
US20210113615A1
(en)
*
|
2018-04-13 |
2021-04-22 |
Ludwig Institute For Cancer Research Ltd. |
Heterodimeric inactivatable chimeric antigen receptors
|
|
KR102251028B1
(ko)
|
2018-04-18 |
2021-05-12 |
앱클론(주) |
스위치 분자 및 스위처블 키메라 항원 수용체
|
|
US11957695B2
(en)
|
2018-04-26 |
2024-04-16 |
The Broad Institute, Inc. |
Methods and compositions targeting glucocorticoid signaling for modulating immune responses
|
|
CN108715616A
(zh)
*
|
2018-04-27 |
2018-10-30 |
上海恒润达生生物科技有限公司 |
靶向人源化间皮素的嵌合抗原受体方法和用途
|
|
US12473342B2
(en)
|
2018-04-27 |
2025-11-18 |
The Trustees Of The University Of Pennsylvania |
Chimeric antigen receptor T regulatory cells for the treatment of atherosclerosis
|
|
EP3784259A4
(en)
|
2018-04-27 |
2021-12-29 |
Seattle Children's Hospital (DBA Seattle Children's Research Institute) |
Rapamycin resistant cells
|
|
US20210396739A1
(en)
|
2018-05-01 |
2021-12-23 |
Novartis Ag |
Biomarkers for evaluating car-t cells to predict clinical outcome
|
|
IL321548A
(en)
|
2018-05-22 |
2025-08-01 |
Immunitybio Inc |
Recombinant NK cells expressing a chimeric antigen receptor (CAR) for epsilon-FC and uses thereof
|
|
WO2019227003A1
(en)
|
2018-05-25 |
2019-11-28 |
Novartis Ag |
Combination therapy with chimeric antigen receptor (car) therapies
|
|
EP3802579A1
(en)
|
2018-06-01 |
2021-04-14 |
The Board of Trustees of the Leland Stanford Junior University |
Il-13/il-4 superkines: immune cell targeting constructs and methods of use thereof
|
|
WO2019232542A2
(en)
|
2018-06-01 |
2019-12-05 |
Massachusetts Institute Of Technology |
Methods and compositions for detecting and modulating microenvironment gene signatures from the csf of metastasis patients
|
|
CN110577604A
(zh)
*
|
2018-06-07 |
2019-12-17 |
亘喜生物科技(上海)有限公司 |
携带gitr共刺激信号靶向egfr的嵌合抗原受体t细胞
|
|
MY208825A
(en)
|
2018-06-13 |
2025-05-30 |
Novartis Ag |
Bcma chimeric antigen receptors and uses thereof
|
|
US12036240B2
(en)
|
2018-06-14 |
2024-07-16 |
The Broad Institute, Inc. |
Compositions and methods targeting complement component 3 for inhibiting tumor growth
|
|
WO2019246563A1
(en)
|
2018-06-22 |
2019-12-26 |
Kite Pharma, Inc. |
Chimeric transmembrane proteins and uses thereof
|
|
CN110669138A
(zh)
*
|
2018-07-02 |
2020-01-10 |
中国药科大学 |
一种双嵌合抗原受体、t细胞及其构建方法与应用
|
|
CA3105658A1
(en)
|
2018-07-13 |
2020-01-16 |
The Regents Of The University Of California |
Retrotransposon-based delivery vehicle and methods of use thereof
|
|
BR112021000914A2
(pt)
|
2018-07-18 |
2021-04-13 |
Amgen Inc. |
Receptores quiméricos para steap1 e seus métodos de uso
|
|
WO2020033927A2
(en)
|
2018-08-09 |
2020-02-13 |
Juno Therapeutics, Inc. |
Processes for generating engineered cells and compositions thereof
|
|
WO2020035488A1
(en)
|
2018-08-13 |
2020-02-20 |
Aarhus Universitet |
Genetically altered lysm receptors with altered agonist specificity and affinity
|
|
CN112601758A
(zh)
|
2018-08-29 |
2021-04-02 |
新加坡国立大学 |
特异性刺激经基因修饰免疫细胞的存活和扩增的方法
|
|
US20210171909A1
(en)
|
2018-08-31 |
2021-06-10 |
Novartis Ag |
Methods of making chimeric antigen receptor?expressing cells
|
|
CN112639083A
(zh)
|
2018-08-31 |
2021-04-09 |
诺华股份有限公司 |
制备表达嵌合抗原受体的细胞的方法
|
|
CN112823166B
(zh)
*
|
2018-09-07 |
2025-01-24 |
生物蛋白有限公司 |
用于修饰的t细胞的条件活性嵌合抗原受体
|
|
EP3856782A1
(en)
|
2018-09-28 |
2021-08-04 |
Novartis AG |
Cd19 chimeric antigen receptor (car) and cd22 car combination therapies
|
|
US20220047633A1
(en)
|
2018-09-28 |
2022-02-17 |
Novartis Ag |
Cd22 chimeric antigen receptor (car) therapies
|
|
US20210382068A1
(en)
|
2018-10-02 |
2021-12-09 |
Dana-Farber Cancer Institute, Inc. |
Hla single allele lines
|
|
EP3860643A1
(en)
|
2018-10-05 |
2021-08-11 |
St. Anna Kinderkrebsforschung |
A group of chimeric antigen receptors (cars)
|
|
EP3632461A1
(en)
|
2018-10-05 |
2020-04-08 |
St. Anna Kinderkrebsforschung |
A group of chimeric antigen receptors (cars)
|
|
EP3632460A1
(en)
|
2018-10-05 |
2020-04-08 |
St. Anna Kinderkrebsforschung |
A group of chimeric antigen receptors (cars)
|
|
CA3112310C
(en)
*
|
2018-10-05 |
2025-05-06 |
Universitat Fur Bodenkultur Wien |
CHIMERIC ANTIGEN RECEPTOR GROUP (CAR)
|
|
GB201816839D0
(en)
*
|
2018-10-16 |
2018-11-28 |
Glaxosmithkline Ip Dev Ltd |
Novel control switch
|
|
US20210379057A1
(en)
|
2018-10-16 |
2021-12-09 |
Massachusetts Institute Of Technology |
Nutlin-3a for use in treating a mycobacterium tuberculosis infection
|
|
MX2021006194A
(es)
|
2018-12-02 |
2021-06-30 |
Fate Therapeutics Inc |
Inmunoterapias mediante el uso de celulas efectoras potenciadas derivadas de ipsc.
|
|
MX2021006578A
(es)
|
2018-12-05 |
2021-07-07 |
Genentech Inc |
Procedimientos de diagnostico y composiciones para la inmunoterapia contra el cancer.
|
|
WO2020118305A1
(en)
*
|
2018-12-07 |
2020-06-11 |
The Trustees Of Columbia University In The City Of New York |
Muc4 car-t cells for treating cancer
|
|
JP7386382B2
(ja)
|
2018-12-12 |
2023-11-27 |
カイト ファーマ インコーポレイテッド |
キメラ抗原受容体及びt細胞受容体並びに使用方法
|
|
US12291560B2
(en)
|
2018-12-14 |
2025-05-06 |
Regeneron Pharmaceuticals, Inc. |
Dimerizing agent regulated immunoreceptor complexes
|
|
WO2020131586A2
(en)
|
2018-12-17 |
2020-06-25 |
The Broad Institute, Inc. |
Methods for identifying neoantigens
|
|
WO2020141106A1
(en)
|
2019-01-03 |
2020-07-09 |
Kemijski Institut |
Engineered externally regulated artificial transcription regulatory system based on engineered nfat
|
|
US11739156B2
(en)
|
2019-01-06 |
2023-08-29 |
The Broad Institute, Inc. Massachusetts Institute of Technology |
Methods and compositions for overcoming immunosuppression
|
|
CN113347991B
(zh)
|
2019-01-23 |
2024-07-30 |
美天施生物科技有限两合公司 |
用于消除和增强受试者骨髓中造血干细胞植入的组合物的组合
|
|
CN113543799B
(zh)
|
2019-03-01 |
2024-08-02 |
艾洛基治疗公司 |
靶向dll3的嵌合抗原受体和结合剂
|
|
CN118546959A
(zh)
*
|
2019-03-05 |
2024-08-27 |
恩卡尔塔公司 |
Cd19定向性嵌合抗原受体及其在免疫疗法中的用途
|
|
US20220154282A1
(en)
|
2019-03-12 |
2022-05-19 |
The Broad Institute, Inc. |
Detection means, compositions and methods for modulating synovial sarcoma cells
|
|
EP3942023A1
(en)
|
2019-03-18 |
2022-01-26 |
The Broad Institute, Inc. |
Compositions and methods for modulating metabolic regulators of t cell pathogenicity
|
|
EP3946382A1
(en)
|
2019-04-04 |
2022-02-09 |
UMC Utrecht Holding B.V. |
Modified immune receptor constructs
|
|
US20220168389A1
(en)
|
2019-04-12 |
2022-06-02 |
Novartis Ag |
Methods of making chimeric antigen receptor-expressing cells
|
|
AU2020259449A1
(en)
|
2019-04-17 |
2021-12-09 |
Aadigen, Llc |
Peptides and nanoparticles for intracellular delivery of molecules
|
|
JP7664180B2
(ja)
|
2019-04-26 |
2025-04-17 |
アロジーン セラピューティクス,インコーポレイテッド |
リツキシマブ耐性キメラ抗原受容体およびその用途
|
|
WO2020219812A1
(en)
|
2019-04-26 |
2020-10-29 |
Allogene Therapeutics, Inc. |
Methods of manufacturing allogeneic car t cells
|
|
KR20220016475A
(ko)
|
2019-05-01 |
2022-02-09 |
주노 쎄러퓨티크스 인코퍼레이티드 |
변형된 tgfbr2 유전자 좌에서 재조합 수용체를 발현하는 세포, 관련 폴리뉴클레오티드 및 방법
|
|
EP3962519A1
(en)
|
2019-05-01 |
2022-03-09 |
Juno Therapeutics, Inc. |
Cells expressing a chimeric receptor from a modified cd247 locus, related polynucleotides and methods
|
|
MX2021013417A
(es)
|
2019-05-04 |
2021-12-10 |
Inhibrx Inc |
Polipeptidos de union a la proteina del miembro a de la familia 12 del dominio de lectina tipo c (clec12a) y sus usos.
|
|
US20220202864A1
(en)
*
|
2019-05-07 |
2022-06-30 |
Gracell Biotechnologies (Shanghai) Co., Ltd. |
Bcma-targeting engineered immune cell and use thereof
|
|
WO2020224606A1
(zh)
|
2019-05-07 |
2020-11-12 |
亘喜生物科技(上海)有限公司 |
靶向bcma的工程化免疫细胞及其用途
|
|
CN114502586B
(zh)
|
2019-05-08 |
2025-06-24 |
瑞泽恩制药公司 |
Cll-1靶向免疫疗法
|
|
US20220235340A1
(en)
|
2019-05-20 |
2022-07-28 |
The Broad Institute, Inc. |
Novel crispr-cas systems and uses thereof
|
|
WO2020243371A1
(en)
|
2019-05-28 |
2020-12-03 |
Massachusetts Institute Of Technology |
Methods and compositions for modulating immune responses
|
|
CA3142108A1
(en)
|
2019-05-28 |
2020-12-03 |
Miltenyi Biotec B.V. & Co. KG |
Method for generation of genetically modified t cells
|
|
WO2020257823A2
(en)
|
2019-06-21 |
2020-12-24 |
Kite Pharma, Inc. |
TGF-β RECEPTORS AND METHODS OF USE
|
|
WO2021016606A1
(en)
*
|
2019-07-24 |
2021-01-28 |
Eureka Therapeutics, Inc. |
Chimeric antigen receptor t cells and uses thereof
|
|
WO2021030627A1
(en)
|
2019-08-13 |
2021-02-18 |
The General Hospital Corporation |
Methods for predicting outcomes of checkpoint inhibition and treatment thereof
|
|
US12421557B2
(en)
|
2019-08-16 |
2025-09-23 |
The Broad Institute, Inc. |
Methods for predicting outcomes and treating colorectal cancer using a cell atlas
|
|
US20220298501A1
(en)
|
2019-08-30 |
2022-09-22 |
The Broad Institute, Inc. |
Crispr-associated mu transposase systems
|
|
US20220315894A1
(en)
|
2019-09-11 |
2022-10-06 |
Miltenyi Biotec B.V. & Co. KG |
Method for Transduction of T Cells in the Presence of Malignant Cells
|
|
US12297426B2
(en)
|
2019-10-01 |
2025-05-13 |
The Broad Institute, Inc. |
DNA damage response signature guided rational design of CRISPR-based systems and therapies
|
|
US12394502B2
(en)
|
2019-10-02 |
2025-08-19 |
The General Hospital Corporation |
Method for predicting HLA-binding peptides using protein structural features
|
|
US12195725B2
(en)
|
2019-10-03 |
2025-01-14 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for modulating and detecting tissue specific TH17 cell pathogenicity
|
|
US11981922B2
(en)
|
2019-10-03 |
2024-05-14 |
Dana-Farber Cancer Institute, Inc. |
Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment
|
|
US11793787B2
(en)
|
2019-10-07 |
2023-10-24 |
The Broad Institute, Inc. |
Methods and compositions for enhancing anti-tumor immunity by targeting steroidogenesis
|
|
US20240122979A1
(en)
*
|
2019-10-08 |
2024-04-18 |
Provincial Health Services Authority |
Chimeric Cytokine Receptors
|
|
US11844800B2
(en)
|
2019-10-30 |
2023-12-19 |
Massachusetts Institute Of Technology |
Methods and compositions for predicting and preventing relapse of acute lymphoblastic leukemia
|
|
US20230053013A1
(en)
*
|
2019-12-03 |
2023-02-16 |
University Of Massachusetts |
Compositions and methods for optogenetic immunotherapy
|
|
CN113087805A
(zh)
*
|
2019-12-31 |
2021-07-09 |
华东师范大学 |
一种共表达免疫调节分子的嵌合抗原受体t细胞的制备及其应用
|
|
JP2023512452A
(ja)
*
|
2020-01-13 |
2023-03-27 |
ンカルタ・インコーポレイテッド |
Bcma指向性細胞免疫療法組成物および方法
|
|
US12165747B2
(en)
|
2020-01-23 |
2024-12-10 |
The Broad Institute, Inc. |
Molecular spatial mapping of metastatic tumor microenvironment
|
|
KR20220130158A
(ko)
|
2020-01-23 |
2022-09-26 |
더 칠드런스 메디칼 센터 코포레이션 |
인간 만능 줄기 세포로부터의 무-간질 t 세포 분화
|
|
CN115066249A
(zh)
|
2020-02-04 |
2022-09-16 |
美天施生物科技有限两合公司 |
表达用于感测可溶性抗原的适体嵌合抗原受体的免疫细胞
|
|
WO2021163618A1
(en)
|
2020-02-14 |
2021-08-19 |
Novartis Ag |
Method of predicting response to chimeric antigen receptor therapy
|
|
JP2023513752A
(ja)
*
|
2020-02-14 |
2023-04-03 |
ベイジン ヨンタイ ルイケ バイオテクノロジー カンパニー リミテッド |
外部から導入された細胞シグナル伝達調節因子を過剰発現する免疫細胞及びその使用
|
|
AU2021225949A1
(en)
|
2020-02-27 |
2022-09-15 |
Novartis Ag |
Methods of making chimeric antigen receptor-expressing cells
|
|
PH12022552283A1
(en)
|
2020-02-27 |
2024-01-22 |
Novartis Ag |
Methods of making chimeric antigen receptor-expressing cells
|
|
KR20220153604A
(ko)
|
2020-03-11 |
2022-11-18 |
더 트러스티스 오브 더 유니버시티 오브 펜실바니아 |
가공된 바이러스 입자를 사용하는 유전자 전달을 위한 방법 및 조성물
|
|
CN113402612A
(zh)
|
2020-03-17 |
2021-09-17 |
西比曼生物科技(香港)有限公司 |
靶向cd19和cd20的联合嵌合抗原受体及其应用
|
|
CN115397517A
(zh)
|
2020-04-17 |
2022-11-25 |
希望之城 |
用于治疗flt3阳性恶性肿瘤的靶向flt3的嵌合抗原受体修饰细胞
|
|
EP3916388A1
(en)
|
2020-05-27 |
2021-12-01 |
Miltenyi Biotec B.V. & Co. KG |
Reagents for detection of chimeric antigen receptor cells
|
|
US12286465B2
(en)
|
2020-05-28 |
2025-04-29 |
Miltenyi Biotec B.V. & Co. KG |
Chimeric antigen receptor with a spacer comprising C2-set Ig-like domains
|
|
KR20230024984A
(ko)
|
2020-06-12 |
2023-02-21 |
엔카르타, 인크. |
Cd70-지시 암 면역요법용 유전적으로 변형된 자연 살해 세포
|
|
EP4168538A4
(en)
|
2020-06-19 |
2024-03-20 |
Fate Therapeutics, Inc. |
COMBINATION OF IPSC-DERIVED EFFECTOR CELL TYPES FOR IMMUNOTHERAPY USE
|
|
WO2021260186A1
(en)
|
2020-06-26 |
2021-12-30 |
Juno Therapeutics Gmbh |
Engineered t cells conditionally expressing a recombinant receptor, related polynucleotides and methods
|
|
AU2021329371A1
(en)
*
|
2020-08-20 |
2023-04-20 |
A2 Biotherapeutics, Inc. |
Compositions and methods for treating mesothelin positive cancers
|
|
EP3964585A1
(en)
|
2020-09-03 |
2022-03-09 |
Miltenyi Biotec B.V. & Co. KG |
Cd62l specific lentiviral vector particle for targeted transduction of t cell subsets
|
|
ES2994677T3
(en)
|
2020-09-04 |
2025-01-29 |
Miltenyi Biotec Bv & Co Kg |
System for inducible expression of an adapter in immune cells
|
|
WO2022098638A2
(en)
|
2020-11-04 |
2022-05-12 |
Genentech, Inc. |
Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies
|
|
JP7716473B2
(ja)
|
2020-11-04 |
2025-07-31 |
ジェネンテック, インコーポレイテッド |
抗cd20/抗cd3二重特異性抗体の皮下投薬
|
|
WO2022096664A1
(en)
|
2020-11-09 |
2022-05-12 |
Miltenyi Biotec B.V. & Co. KG |
Methods and compositions for eliminating engineered immune cells
|
|
CN116635062A
(zh)
|
2020-11-13 |
2023-08-22 |
诺华股份有限公司 |
使用表达嵌合抗原受体(car)的细胞的组合疗法
|
|
MX2023005491A
(es)
|
2020-11-24 |
2023-08-09 |
Lyell Immunopharma Inc |
Métodos de preparación de células t rejuvenecidas, composiciones que las comprenden y métodos de uso de las mismas.
|
|
IL303270A
(en)
|
2020-12-21 |
2023-07-01 |
Allogene Therapeutics Inc |
The CD45–GATE vehicle activates a protease
|
|
WO2022165378A1
(en)
*
|
2021-01-29 |
2022-08-04 |
Outpace Bio, Inc. |
Small molecule-regulated cell signaling expression system
|
|
WO2022173703A1
(en)
*
|
2021-02-10 |
2022-08-18 |
The Regents Of The University Of California |
Immune receptors with synthetic co-stimulatory domains
|
|
US12144827B2
(en)
|
2021-02-25 |
2024-11-19 |
Lyell Immunopharma, Inc. |
ROR1 targeting chimeric antigen receptor
|
|
GB202104030D0
(en)
*
|
2021-03-23 |
2021-05-05 |
Autolus Ltd |
Signalling system
|
|
US20240180969A1
(en)
*
|
2021-04-01 |
2024-06-06 |
A2 Biotherapeutics, Inc. |
Polypeptides targeting hla-a*11 and methods of use thereof
|
|
CA3218578A1
(en)
|
2021-05-14 |
2022-11-17 |
Carol Elaine O'hear |
Methods for treatment of cd20-positive proliferative disorder with mosunetuzumab and polatuzumab vedotin
|
|
GB202108366D0
(en)
|
2021-06-11 |
2021-07-28 |
Quell Therapeutics Ltd |
Multichain chimeric antigen receptor
|
|
EP4376876A1
(en)
|
2021-07-26 |
2024-06-05 |
Kite Pharma, Inc. |
Split chimeric antigen receptors and methods of use
|
|
WO2023044304A1
(en)
*
|
2021-09-15 |
2023-03-23 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Chimeric adaptor and kinase signaling proteins and their use in immunotherapy
|
|
US20250235477A1
(en)
|
2021-10-06 |
2025-07-24 |
Miltenyi Biotec B.V. & Co. KG |
Method for targeted gene insertion into immune cells
|
|
WO2023064928A2
(en)
|
2021-10-14 |
2023-04-20 |
Arsenal Biosciences, Inc. |
Immune cells having co-expressed shrnas and logic gate systems
|
|
WO2023062113A1
(en)
|
2021-10-15 |
2023-04-20 |
Miltenyi Biotec B.V. & Co. KG |
Method for the generation of genetically modified nk cells
|
|
WO2023130462A1
(zh)
*
|
2022-01-10 |
2023-07-13 |
卡瑞济(北京)生命科技有限公司 |
靶向IL13Rα2的嵌合抗原受体及其用途
|
|
CN114736306B
(zh)
*
|
2022-03-01 |
2024-04-19 |
中国科学院深圳先进技术研究院 |
一种受化学调控的蛋白酶工具及其配套底物
|
|
CN118973608A
(zh)
|
2022-04-01 |
2024-11-15 |
美天施生物科技有限两合公司 |
用于多核苷酸的药物诱导型表达的系统
|
|
CA3247423A1
(en)
|
2022-04-08 |
2023-10-12 |
Fate Therapeutics, Inc. |
CELLS WITH A SOLID TUMOR-TARGETING SKELETON AND THEIR USE
|
|
US20250222029A1
(en)
|
2022-04-08 |
2025-07-10 |
Fate Therapeutics, Inc. |
Chimeric antigen receptor for tumor targeting
|
|
EP4522751A1
(en)
|
2022-05-10 |
2025-03-19 |
Miltenyi Biotec B.V. & Co. KG |
Compositions comprising il-15, il-15 receptor alpha and the intracellular signaling domain of cd2 for immune cell therapy
|
|
WO2023220459A1
(en)
*
|
2022-05-13 |
2023-11-16 |
Northwestern University |
Active loading of cargo entity into lipid bilayer particles using dimerization domains
|
|
US20250339464A1
(en)
|
2022-05-16 |
2025-11-06 |
Miltenyi Biotec B.V. & Co. KG |
Endogenous signaling molecule activating chimeric antigen receptors and methods of generation thereof
|
|
WO2024050325A2
(en)
*
|
2022-09-01 |
2024-03-07 |
Sri International |
Genetically engineered cd4 t-cells for in situ synthesis of proteins
|
|
IL319225A
(en)
|
2022-09-15 |
2025-04-01 |
Novartis Ag |
Treatment of autoimmune disorders using antigen receptor chemotherapeutics
|
|
EP4342488A1
(en)
|
2022-09-26 |
2024-03-27 |
Miltenyi Biotec B.V. & Co. KG |
Chimeric antigen receptor specific for folate receptor 1
|
|
WO2024077256A1
(en)
|
2022-10-07 |
2024-04-11 |
The General Hospital Corporation |
Methods and compositions for high-throughput discovery ofpeptide-mhc targeting binding proteins
|
|
WO2024078995A1
(en)
|
2022-10-15 |
2024-04-18 |
Miltenyi Biotec B.V. & Co. KG |
Transduction of gammadelta t cells with pseudotyped retroviral vectors
|
|
KR102834479B1
(ko)
*
|
2022-11-04 |
2025-07-16 |
한국과학기술연구원 |
형광공명에너지전이 기반 car 활성 센싱용 바이오센서 및 그의 용도
|
|
TW202440623A
(zh)
|
2022-11-28 |
2024-10-16 |
美商艾洛基因醫療公司 |
靶向密連蛋白18﹒2之嵌合抗原受體及結合劑以及其用途
|
|
WO2024124044A1
(en)
|
2022-12-07 |
2024-06-13 |
The Brigham And Women’S Hospital, Inc. |
Compositions and methods targeting sat1 for enhancing anti¬ tumor immunity during tumor progression
|
|
WO2024158800A2
(en)
*
|
2023-01-24 |
2024-08-02 |
Ginkgo Bioworks, Inc. |
Immune cell stimulatory sequences
|
|
WO2024182539A1
(en)
|
2023-02-28 |
2024-09-06 |
Lyell Immunopharma, Inc. |
Methods of culturing reprogrammed cells
|
|
EP4626447A1
(en)
|
2023-03-31 |
2025-10-08 |
AbelZeta Inc. |
Bispecific chimeric antigen receptors targeting cd20 and bcma
|
|
WO2024223847A1
(en)
|
2023-04-27 |
2024-10-31 |
Miltenyi Biotec B.V. & Co. KG |
Pseudotyped retroviral vector particle with anti-cd3 display
|
|
AU2024261890A1
(en)
|
2023-04-27 |
2025-10-09 |
Miltenyi Biotec B.V. & Co. KG |
Retroviral vector particle pseudotyped with envelope proteins of canine distemper virus
|
|
EP4470555A1
(en)
|
2023-05-31 |
2024-12-04 |
Miltenyi Biotec B.V. & Co. KG |
Anti-tag chimeric antigen receptors with specificity for mutated peptides derived from human fgfr2
|
|
EP4471067A1
(en)
|
2023-06-01 |
2024-12-04 |
Miltenyi Biotec B.V. & Co. KG |
A chemically inducible heterodimerizing system and a method for generation thereof
|
|
WO2025008108A1
(en)
|
2023-07-06 |
2025-01-09 |
Miltenyi Biotec B.V. & Co. KG |
Immune cell expressing chimeric antigen receptor and transgenic t cell receptor
|
|
WO2025059533A1
(en)
|
2023-09-13 |
2025-03-20 |
The Broad Institute, Inc. |
Crispr enzymes and systems
|
|
WO2025078492A1
(en)
|
2023-10-13 |
2025-04-17 |
Miltenyi Biotec B.V. & Co. KG |
Cd3-targeted nipah-pseudotyped lentiviral vector particles
|
|
EP4545963A1
(en)
|
2023-10-26 |
2025-04-30 |
Miltenyi Biotec B.V. & Co. KG |
Method for selecting antigen recognizing moieties having specificity for a target structure
|
|
WO2025097055A2
(en)
|
2023-11-02 |
2025-05-08 |
The Broad Institute, Inc. |
Compositions and methods of use of t cells in immunotherapy
|
|
WO2025117544A1
(en)
|
2023-11-29 |
2025-06-05 |
The Broad Institute, Inc. |
Engineered omega guide molecule and iscb compositions, systems, and methods of use thereof
|
|
WO2025224123A1
(en)
|
2024-04-25 |
2025-10-30 |
Miltenyi Biotec B.V. & Co. KG |
Chimeric antigen receptors specific for fibroblast activation protein
|
|
WO2025252326A1
(en)
|
2024-06-06 |
2025-12-11 |
Miltenyi Biotec B.V. & Co. KG |
A human protein scaffold library based on the n-terminal domain of human fact complex subunit ssrp1
|
|
WO2025252325A1
(en)
|
2024-06-06 |
2025-12-11 |
Miltenyi Biotec B.V. & Co. KG |
A human protein scaffold library based on the pdz3 domain of the tight junction protein zo-1
|