|
USRE30985E
(en)
|
1978-01-01 |
1982-06-29 |
|
Serum-free cell culture media
|
|
US4399216A
(en)
|
1980-02-25 |
1983-08-16 |
The Trustees Of Columbia University |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US5179017A
(en)
|
1980-02-25 |
1993-01-12 |
The Trustees Of Columbia University In The City Of New York |
Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
|
|
US4510245A
(en)
|
1982-11-18 |
1985-04-09 |
Chiron Corporation |
Adenovirus promoter system
|
|
US4560655A
(en)
|
1982-12-16 |
1985-12-24 |
Immunex Corporation |
Serum-free cell culture medium and process for making same
|
|
US4657866A
(en)
|
1982-12-21 |
1987-04-14 |
Sudhir Kumar |
Serum-free, synthetic, completely chemically defined tissue culture media
|
|
JPS59156299A
(ja)
|
1983-02-28 |
1984-09-05 |
Noda Sangyo Kagaku Kenkyusho |
N−アセチルヘキソサミンの定量法及びその定量用試薬
|
|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
|
US4534972A
(en)
|
1983-03-29 |
1985-08-13 |
Miles Laboratories, Inc. |
Protein compositions substantially free from infectious agents
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
DD266710A3
(de)
|
1983-06-06 |
1989-04-12 |
Ve Forschungszentrum Biotechnologie |
Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase
|
|
US4767704A
(en)
|
1983-10-07 |
1988-08-30 |
Columbia University In The City Of New York |
Protein-free culture medium
|
|
EP0154316B1
(en)
|
1984-03-06 |
1989-09-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified lymphokine and production thereof
|
|
US4879231A
(en)
|
1984-10-30 |
1989-11-07 |
Phillips Petroleum Company |
Transformation of yeasts of the genus pichia
|
|
US5168062A
(en)
|
1985-01-30 |
1992-12-01 |
University Of Iowa Research Foundation |
Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
|
|
GB8516415D0
(en)
|
1985-06-28 |
1985-07-31 |
Celltech Ltd |
Culture of animal cells
|
|
US4968615A
(en)
|
1985-12-18 |
1990-11-06 |
Ciba-Geigy Corporation |
Deoxyribonucleic acid segment from a virus
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US4927762A
(en)
|
1986-04-01 |
1990-05-22 |
Cell Enterprises, Inc. |
Cell culture medium with antioxidant
|
|
GB8610600D0
(en)
|
1986-04-30 |
1986-06-04 |
Novo Industri As |
Transformation of trichoderma
|
|
US5045468A
(en)
*
|
1986-12-12 |
1991-09-03 |
Cell Enterprises, Inc. |
Protein-free culture medium which promotes hybridoma growth
|
|
US5476996A
(en)
|
1988-06-14 |
1995-12-19 |
Lidak Pharmaceuticals |
Human immune system in non-human animal
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
US6048728A
(en)
*
|
1988-09-23 |
2000-04-11 |
Chiron Corporation |
Cell culture medium for enhanced cell growth, culture longevity, and product expression
|
|
DE68925971T2
(de)
|
1988-09-23 |
1996-09-05 |
Cetus Oncology Corp |
Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte
|
|
WO1990006952A1
(fr)
|
1988-12-22 |
1990-06-28 |
Kirin-Amgen, Inc. |
Facteur de stimulation de colonies de granulocytes modifies chimiquement
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
EP0402226A1
(en)
|
1989-06-06 |
1990-12-12 |
Institut National De La Recherche Agronomique |
Transformation vectors for yeast yarrowia
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
US5110913A
(en)
*
|
1990-05-25 |
1992-05-05 |
Miles Inc. |
Antibody purification method
|
|
US5096816A
(en)
*
|
1990-06-05 |
1992-03-17 |
Cetus Corporation |
In vitro management of ammonia's effect on glycosylation of cell products through pH control
|
|
CA2109602C
(en)
|
1990-07-10 |
2002-10-01 |
Gregory P. Winter |
Methods for producing members of specific binding pairs
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
US5122469A
(en)
|
1990-10-03 |
1992-06-16 |
Genentech, Inc. |
Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
|
|
ES2113940T3
(es)
|
1990-12-03 |
1998-05-16 |
Genentech Inc |
Metodo de enriquecimiento para variantes de proteinas con propiedades de union alteradas.
|
|
DE69233769D1
(de)
|
1991-03-01 |
2009-09-24 |
Dyax Corp |
Chimäres Protein mit Mikroprotein mit zwei oder mehr Disulfidbindungen und Ausgestaltungen davon
|
|
AU662148B2
(en)
|
1991-04-10 |
1995-08-24 |
Scripps Research Institute, The |
Heterodimeric receptor libraries using phagemids
|
|
DE4122599C2
(de)
|
1991-07-08 |
1993-11-11 |
Deutsches Krebsforsch |
Phagemid zum Screenen von Antikörpern
|
|
EP0666312A1
(en)
*
|
1994-02-08 |
1995-08-09 |
Wolfgang A. Renner |
Process for the improvement of mammalian cell growth
|
|
US5429746A
(en)
*
|
1994-02-22 |
1995-07-04 |
Smith Kline Beecham Corporation |
Antibody purification
|
|
US5853714A
(en)
*
|
1995-03-27 |
1998-12-29 |
Genetics Institute, Inc. |
Method for purification of IL-12
|
|
US5641870A
(en)
*
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
|
US5705364A
(en)
*
|
1995-06-06 |
1998-01-06 |
Genentech, Inc. |
Mammalian cell culture process
|
|
US5721121A
(en)
*
|
1995-06-06 |
1998-02-24 |
Genentech, Inc. |
Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein
|
|
US6656466B1
(en)
*
|
1995-06-06 |
2003-12-02 |
Genetech, Inc. |
Human tumor necrosis factor—immunoglobulin(TNFR1-IgG1) chimera composition
|
|
JP4306813B2
(ja)
*
|
1995-09-19 |
2009-08-05 |
アスビオファーマ株式会社 |
動物細胞の新規培養方法
|
|
DE69623109T2
(de)
*
|
1996-04-19 |
2002-12-12 |
Societe Des Produits Nestle S.A., Vevey |
Menschliche immortalisierte Colon-Epithelialzellen
|
|
WO1998017786A1
(en)
|
1996-10-23 |
1998-04-30 |
Oravax, Inc. |
Heat inactivation of viruses in antibody preparations
|
|
PT936923E
(pt)
*
|
1996-11-15 |
2004-04-30 |
Kennedy Inst Of Rheumatology |
Supressao de tnfalfa e il-12 em terapia
|
|
ES2337091T3
(es)
*
|
1996-11-27 |
2010-04-20 |
Genentech, Inc. |
Purificacion por afinidad de polipeptido en una matriz de proteina.
|
|
US6955917B2
(en)
*
|
1997-06-20 |
2005-10-18 |
Bayer Healthcare Llc |
Chromatographic method for high yield purification and viral inactivation of antibodies
|
|
IL121900A
(en)
|
1997-10-07 |
2001-12-23 |
Omrix Biopharmaceuticals Ltd |
A method for the purification of immunoglobulins
|
|
US20020045207A1
(en)
*
|
1997-10-31 |
2002-04-18 |
Lynne A. Krummen |
Glycoprotein production process
|
|
AU1663599A
(en)
|
1997-12-19 |
1999-07-12 |
Novo Nordisk A/S |
Method for producing heterologous proteins in eukaryotic cells on an industrial scale using nucleotide-manipulating agents
|
|
BRPI9910332B8
(pt)
*
|
1998-05-06 |
2021-05-25 |
Genentech Inc |
método para purificação de um polipeptídio a partir de uma composição
|
|
US6528286B1
(en)
*
|
1998-05-29 |
2003-03-04 |
Genentech, Inc. |
Mammalian cell culture process for producing glycoproteins
|
|
US6914128B1
(en)
*
|
1999-03-25 |
2005-07-05 |
Abbott Gmbh & Co. Kg |
Human antibodies that bind human IL-12 and methods for producing
|
|
ATE474052T1
(de)
*
|
1999-09-27 |
2010-07-15 |
Genentech Inc |
Verfahren zur herstellung von rekombinanten proteinen mittels inhibitoren von apoptose
|
|
DE60120356T2
(de)
*
|
2000-02-08 |
2007-06-14 |
Genentech, Inc., South San Francisco |
Verbesserte galactosylierung von rekombinanten proteinen
|
|
PL356836A1
(en)
|
2000-02-10 |
2004-07-12 |
Abbott Laboratories |
Antibodies that bind human interleukin-18 and methods of making and using
|
|
US7598055B2
(en)
|
2000-06-28 |
2009-10-06 |
Glycofi, Inc. |
N-acetylglucosaminyltransferase III expression in lower eukaryotes
|
|
EP1175931A1
(en)
*
|
2000-07-25 |
2002-01-30 |
Computer Cell Culture Center S.A. |
Integration of high cell density bioreactor operation with ultra fast on-line downstream processing
|
|
WO2002016590A2
(en)
*
|
2000-08-21 |
2002-02-28 |
Clonex Development, Inc. |
Methods and compositions for increasing protein yield from a cell culture
|
|
US6693173B2
(en)
*
|
2000-12-26 |
2004-02-17 |
Alpha Therapeutic Corporation |
Method to remove citrate and aluminum from proteins
|
|
US20030096414A1
(en)
*
|
2001-03-27 |
2003-05-22 |
Invitrogen Corporation |
Culture medium for cell growth and transfection
|
|
EP1970448A1
(en)
|
2001-05-11 |
2008-09-17 |
Kirin Pharma Kabushiki Kaisha |
Human artificial chromosome containting human antibody lambda light chain and non-human animal containting the human artificial chromosome capable of genetic transmission
|
|
ES2266535T3
(es)
*
|
2001-06-05 |
2007-03-01 |
Genetics Institute, Llc |
Procedimientos relativos a la purificacion de proteinas altamente anionicas.
|
|
NZ581474A
(en)
*
|
2001-08-03 |
2011-04-29 |
Glycart Biotechnology Ag |
Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
|
|
HUP0402158A2
(hu)
*
|
2001-10-02 |
2005-01-28 |
Novo Nordisk Health Care Ag |
Rekombináns fehérjék előállítási eljárása eukarióta sejtekben
|
|
KR100988949B1
(ko)
*
|
2001-10-25 |
2010-10-20 |
제넨테크, 인크. |
당단백질 조성물
|
|
AU2002342922A1
(en)
|
2001-11-28 |
2003-06-10 |
Sandoz Ag |
Cell culture process
|
|
PL374311A1
(en)
*
|
2001-12-21 |
2005-10-03 |
Immunex Corporation |
Methods for purifying protein
|
|
US20030201229A1
(en)
*
|
2002-02-04 |
2003-10-30 |
Martin Siwak |
Process for prefiltration of a protein solution
|
|
CA2473144C
(en)
*
|
2002-02-05 |
2013-05-28 |
Genentech, Inc. |
Protein purification
|
|
CA2417689C
(en)
*
|
2002-03-05 |
2006-05-09 |
F. Hoffmann-La Roche Ag |
Improved methods for growing mammalian cells in vitro
|
|
US20030190710A1
(en)
*
|
2002-03-28 |
2003-10-09 |
Devries Ruth L. |
Control of glycoforms in IgG
|
|
CA2481837A1
(en)
*
|
2002-04-09 |
2003-10-16 |
Kyowa Hakko Kogyo Co., Ltd. |
Production process for antibody composition
|
|
RU2304587C2
(ru)
*
|
2002-06-10 |
2007-08-20 |
Гуд Байотек Копэрейшн |
СПОСОБ СЕЛЕКТИВНОГО ВЫДЕЛЕНИЯ АНТИТЕЛ IgY ИЗ ЯИЧНОГО ЖЕЛТКА ПТИЦ ОТРЯДА ГУСЕОБРАЗНЫХ (ВАРИАНТЫ)
|
|
WO2004008100A2
(en)
|
2002-07-15 |
2004-01-22 |
Immunex Corporation |
Methods and media for controlling sialylation of proteins produced by mammalian cells
|
|
PL218992B1
(pl)
*
|
2002-07-19 |
2015-02-27 |
Abbott Biotech Ltd |
Neutralizujące o wysokim powinowactwie izolowane ludzkie przeciwciało anty-TNFα, zastosowanie tego przeciwciała, kryształ zawierający ludzkie przeciwciało anty-TNFα i preparat zawierający ten kryształ
|
|
US6974681B1
(en)
*
|
2002-08-23 |
2005-12-13 |
Immunex Corporation |
Cell culture performance with vanadate
|
|
US7067279B1
(en)
*
|
2002-08-23 |
2006-06-27 |
Immunex Corporation |
Cell culture performance with betaine
|
|
CA2499269A1
(en)
*
|
2002-09-17 |
2004-04-01 |
Gtc Biotherapeutics, Inc. |
Isolation of immunoglobulin molecules that lack inter-heavy chain disulfide bonds
|
|
US7208585B2
(en)
*
|
2002-09-18 |
2007-04-24 |
Genencor International, Inc. |
Protein purification
|
|
US20040162414A1
(en)
|
2002-11-22 |
2004-08-19 |
Santora Ling C. |
Method for reducing or preventing modification of a polypeptide in solution
|
|
US7332303B2
(en)
*
|
2002-12-23 |
2008-02-19 |
Bristol-Myers Squibb Company |
Product quality enhancement in mammalian cell culture processes for protein production
|
|
AU2003300276B2
(en)
|
2002-12-23 |
2010-07-01 |
Bristol-Myers Squibb Company |
Mammalian cell culture processes for protein production
|
|
US7429491B2
(en)
*
|
2003-05-15 |
2008-09-30 |
Wyeth |
Restricted glucose feed for animal cell culture
|
|
HUE029951T2
(en)
*
|
2003-07-28 |
2017-04-28 |
Genentech Inc |
Reduction of Protein A Dissolution in Protein A Affinity Chromatography
|
|
GB2404665B
(en)
*
|
2003-08-08 |
2005-07-06 |
Cambridge Antibody Tech |
Cell culture
|
|
JP4740138B2
(ja)
*
|
2003-10-10 |
2011-08-03 |
ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト |
真核生物細胞におけるポリペプチドの大規模生産方法及びそれに適した培養容器
|
|
RU2409591C2
(ru)
*
|
2003-10-27 |
2011-01-20 |
Вайет |
Удаление агрегатов с высокой молекулярной массой путем хроматографии на гидроксиапатитах
|
|
US8084032B2
(en)
|
2004-01-21 |
2011-12-27 |
Ajinomoto Co., Inc. |
Purification method which prevents denaturation of an antibody
|
|
SE0400886D0
(sv)
*
|
2004-04-02 |
2004-04-02 |
Amersham Biosciences Ab |
Process of purification
|
|
US20060127950A1
(en)
*
|
2004-04-15 |
2006-06-15 |
Massachusetts Institute Of Technology |
Methods and products related to the improved analysis of carbohydrates
|
|
KR20070008645A
(ko)
|
2004-05-04 |
2007-01-17 |
노보 노르디스크 헬스 케어 악티엔게젤샤프트 |
폴리펩티드의 o-연결된 단백당형 및 그들의 제조 방법
|
|
TWI384069B
(zh)
|
2004-08-27 |
2013-02-01 |
Pfizer Ireland Pharmaceuticals |
多胜肽之製法
|
|
DK1807101T3
(en)
*
|
2004-09-30 |
2016-05-23 |
Bayer Healthcare Llc |
Devices and methods for integrated continuous production of biological molecules
|
|
US20060094104A1
(en)
|
2004-10-29 |
2006-05-04 |
Leopold Grillberger |
Animal protein-free media for cultivation of cells
|
|
JP2006143601A
(ja)
*
|
2004-11-16 |
2006-06-08 |
Yamato Yakuhin Kk |
血液粘度低下剤
|
|
US8728828B2
(en)
*
|
2004-12-22 |
2014-05-20 |
Ge Healthcare Bio-Sciences Ab |
Purification of immunoglobulins
|
|
ES2380485T3
(es)
|
2005-02-11 |
2012-05-14 |
Novo Nordisk Health Care Ag |
Producción de un polipéptido en un lÃquido de cultivo sin suero con hidrolizado de proteÃnas vegetales
|
|
DK1869065T3
(da)
*
|
2005-03-11 |
2020-06-08 |
Wyeth Llc |
Fremgangsmåde til kromatografi med svag opdeling
|
|
US8129508B2
(en)
|
2005-04-11 |
2012-03-06 |
Medarex, Inc. |
Protein purification using HCIC and ion exchange chromatography
|
|
US20090203055A1
(en)
*
|
2005-04-18 |
2009-08-13 |
Massachusetts Institute Of Technology |
Compositions and methods for RNA interference with sialidase expression and uses thereof
|
|
US7247457B2
(en)
*
|
2005-04-26 |
2007-07-24 |
United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention |
Detection and identification of enteroviruses by semi-nested amplification of the enterovirus VP1 protein
|
|
WO2006133148A2
(en)
*
|
2005-06-03 |
2006-12-14 |
Genentech, Inc. |
Method of producing antibodies with modified fucosylation level
|
|
WO2006138181A2
(en)
*
|
2005-06-14 |
2006-12-28 |
Amgen Inc. |
Self-buffering protein formulations
|
|
BRPI0611600B8
(pt)
|
2005-06-17 |
2021-05-25 |
Wyeth Corp |
método para purificação de uma proteína tendo uma região fc a partir de um líquido fonte compreendendo a proteína e uma ou mais impurezas, e kit
|
|
DK1917276T3
(en)
*
|
2005-08-26 |
2018-05-07 |
Ares Trading Sa |
Process for Preparation of Glycosylated Interferon Beta
|
|
AR058140A1
(es)
*
|
2005-10-24 |
2008-01-23 |
Wyeth Corp |
Metodo de produccion proteica utilizando compuestos anti-senescencia
|
|
SI1957630T2
(sl)
*
|
2005-12-08 |
2023-07-31 |
Amgen Inc. |
Izboljšana proizvodnja glikoproteinov z uporabo mangana
|
|
US20070190057A1
(en)
|
2006-01-23 |
2007-08-16 |
Jian Wu |
Methods for modulating mannose content of recombinant proteins
|
|
EP2738179A1
(en)
*
|
2006-04-05 |
2014-06-04 |
AbbVie Biotechnology Ltd |
Antibody purification
|
|
AU2007254141B2
(en)
*
|
2006-05-19 |
2012-10-11 |
Glycofi, Inc. |
Erythropoietin compositions
|
|
JP2010510963A
(ja)
*
|
2006-06-14 |
2010-04-08 |
グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー |
セラミックヒドロキシアパタイトを使用する抗体の精製方法
|
|
WO2008007280A2
(en)
|
2006-06-28 |
2008-01-17 |
Koninklijke Philips Electronics N.V. |
Assay system and method
|
|
KR101495549B1
(ko)
|
2006-07-13 |
2015-02-25 |
와이어쓰 엘엘씨 |
당단백질의 생산
|
|
US8513393B2
(en)
*
|
2006-08-28 |
2013-08-20 |
Ares Trading S.A. |
Process for the purification of Fc-containing proteins
|
|
AR062711A1
(es)
*
|
2006-09-08 |
2008-11-26 |
Wyeth Corp |
Lavado de arginina en l a purificacion de proteinas usando cromatografia de afinidad
|
|
MX353340B
(es)
*
|
2006-09-13 |
2018-01-09 |
Abbvie Inc |
Mejoras de cultivos celulares.
|
|
US8911964B2
(en)
*
|
2006-09-13 |
2014-12-16 |
Abbvie Inc. |
Fed-batch method of making human anti-TNF-alpha antibody
|
|
WO2008036600A2
(en)
*
|
2006-09-18 |
2008-03-27 |
Genentech, Inc. |
Methods of protein production
|
|
US20080132688A1
(en)
|
2006-09-22 |
2008-06-05 |
Amgen Inc. |
Methods for Removing Viral Contaminants During Protein Purification
|
|
US8192951B2
(en)
*
|
2006-11-03 |
2012-06-05 |
Wyeth Llc |
Glycolysis-inhibiting substances in cell culture
|
|
EP2089424B1
(en)
|
2006-12-06 |
2015-07-01 |
JCR PHARMACEUTICALS Co., LTD. |
Method for production of human erythropoietin
|
|
WO2008079280A1
(en)
*
|
2006-12-21 |
2008-07-03 |
Millipore Corporation |
Purification of proteins
|
|
RU2009132986A
(ru)
*
|
2007-03-02 |
2011-04-10 |
Уайт (Us) |
Применение меди и глутамата в культуре клеток для производства полипептидов
|
|
WO2008121324A2
(en)
*
|
2007-03-30 |
2008-10-09 |
Abbott Laboratories |
Recombinant expression vector elements (reves) for enhancing expression of recombinant proteins in host cells
|
|
US20100209434A1
(en)
*
|
2007-03-30 |
2010-08-19 |
Medimmune, Llc |
Antibody formulation
|
|
EP2134853B1
(en)
*
|
2007-04-03 |
2018-07-18 |
Oxyrane UK Limited |
Glycosylation of molecules
|
|
US20100113294A1
(en)
|
2007-04-16 |
2010-05-06 |
Momenta Pharmaceuticals, Inc. |
Defined glycoprotein products and related methods
|
|
TW200902708A
(en)
*
|
2007-04-23 |
2009-01-16 |
Wyeth Corp |
Methods of protein production using anti-senescence compounds
|
|
EP1988101A1
(en)
|
2007-05-04 |
2008-11-05 |
Novo Nordisk A/S |
Improvement of factor VIII polypeptide titers in cell cultures
|
|
WO2008135498A2
(en)
|
2007-05-04 |
2008-11-13 |
Novo Nordisk A/S |
Prevention of protein degradation in mammalian cell cultures
|
|
WO2008141207A1
(en)
|
2007-05-11 |
2008-11-20 |
Amgen Inc. |
Improved feed media
|
|
WO2008154014A2
(en)
*
|
2007-06-11 |
2008-12-18 |
Amgen Inc. |
A method for culturing mammalian cells to improve recombinant protein production
|
|
HUE037162T2
(hu)
*
|
2007-07-09 |
2018-08-28 |
Genentech Inc |
Diszulfidkötés redukciójának megelõzése polipeptidek rekombináns elõállítása során
|
|
EP2188371B1
(en)
|
2007-08-09 |
2017-12-20 |
Wyeth LLC |
Use of perfusion to enhance production of fed-batch cell culture in bioreactors
|
|
CN105315323A
(zh)
|
2007-10-30 |
2016-02-10 |
健泰科生物技术公司 |
通过阳离子交换层析进行的抗体纯化
|
|
WO2009058769A1
(en)
|
2007-10-30 |
2009-05-07 |
Schering Corporation |
Purification of antibodies containing hydrophobic variants
|
|
TWM332870U
(en)
*
|
2007-11-22 |
2008-05-21 |
Delta Electronics Inc |
Side-edge type backlight module
|
|
KR20210049186A
(ko)
*
|
2007-11-30 |
2021-05-04 |
애브비 바이오테크놀로지 리미티드 |
단백질 제형 및 이의 제조방법
|
|
CA2709890A1
(en)
|
2007-12-27 |
2009-07-09 |
Andre Giovagnoli |
Cell culture processes
|
|
US8093364B2
(en)
*
|
2008-01-18 |
2012-01-10 |
Bio-Rad Laboratories, Inc. |
Enhanced purification of antibodies and antibody fragments by apatite chromatography
|
|
EP2271669A1
(en)
*
|
2008-03-11 |
2011-01-12 |
Genentech, Inc. |
Antibodies with enhanced adcc function
|
|
PT2271382E
(pt)
*
|
2008-04-15 |
2013-05-07 |
Grifols Therapeutics Inc |
Ultrafiltração em dois andares/diafiltração
|
|
CN102076865B
(zh)
*
|
2008-05-02 |
2016-03-16 |
西雅图基因公司 |
用于制造核心岩藻糖基化降低的抗体和抗体衍生物的方法和组合物
|
|
WO2010016943A2
(en)
|
2008-08-08 |
2010-02-11 |
Biogen Idec Ma Inc. |
Nutrient monitoring and feedback control for increased bioproduct production
|
|
ES2978373T3
(es)
*
|
2008-08-14 |
2024-09-11 |
Genentech Inc |
Métodos para eliminar un contaminante usando cromatografía de membrana de intercambio iónico de desplazamiento de proteínas indígenas
|
|
CN102216452B
(zh)
|
2008-09-26 |
2013-08-21 |
尤里卡治疗公司 |
具有变异糖基化方式的细胞系和蛋白质
|
|
WO2010048190A2
(en)
|
2008-10-20 |
2010-04-29 |
Abbott Laboratories |
Antibodies that bind to il-12 and methods of purifying the same
|
|
SG195577A1
(en)
*
|
2008-10-20 |
2013-12-30 |
Abbott Lab |
Viral inactivation during purification of antibodies
|
|
TW201024318A
(en)
*
|
2008-10-20 |
2010-07-01 |
Abbott Lab |
Isolation and purification of antibodies using protein A affinity chromatography
|
|
EP2346901A1
(en)
|
2008-10-20 |
2011-07-27 |
Abbott Laboratories |
Antibodies that bind to il-18 and methods of purifying the same
|
|
WO2010051360A1
(en)
*
|
2008-10-31 |
2010-05-06 |
Wyeth Llc |
Purification of acidic proteins using ceramic hydroxyapatite chromatography
|
|
US20110236391A1
(en)
*
|
2008-12-09 |
2011-09-29 |
Hanns-Christian Mahler |
Method for obtaining an excipient-free antibody solution
|
|
EP2379108B1
(en)
|
2008-12-22 |
2014-06-25 |
F. Hoffmann-La Roche AG |
Immunoglobulin purification
|
|
JP5785098B2
(ja)
|
2009-01-08 |
2015-09-24 |
ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ |
単一ポリマー相系を用いる分離方法
|
|
US9127043B2
(en)
|
2009-03-05 |
2015-09-08 |
Biogen Ma Inc. |
Purification of immunoglobulins
|
|
JP5755136B2
(ja)
*
|
2009-03-27 |
2015-07-29 |
旭化成メディカル株式会社 |
高濃度モノクローナル抗体溶液中のウイルス除去方法
|
|
TW201041899A
(en)
|
2009-04-13 |
2010-12-01 |
Bristol Myers Squibb Co |
Protein purification by citrate precipitation
|
|
CN102803292A
(zh)
*
|
2009-04-20 |
2012-11-28 |
辉瑞公司 |
蛋白质糖基化的控制及其相关组合物和方法
|
|
KR20120042744A
(ko)
*
|
2009-05-28 |
2012-05-03 |
베링거 인겔하임 인터내셔날 게엠베하 |
합리적인 세포 배양 공정을 위한 방법
|
|
US20120277165A1
(en)
*
|
2009-06-05 |
2012-11-01 |
Collins Brian E |
Methods of modulating fucosylation of glycoproteins
|
|
JP2012531930A
(ja)
|
2009-07-06 |
2012-12-13 |
ジェネンテック, インコーポレイテッド |
真核生物細胞の培養方法
|
|
CN102471377B
(zh)
|
2009-07-24 |
2015-04-22 |
霍夫曼-拉罗奇有限公司 |
优化抗体的生产
|
|
WO2011015926A1
(en)
|
2009-08-03 |
2011-02-10 |
Avesthagen Limited |
A process of fermentation, purification and production of recombinant soluble tumour necrosis factor alfa receptor (tnfr) - human igg fc fusion protein
|
|
AU2010292897B2
(en)
|
2009-08-06 |
2016-01-07 |
Genentech, Inc. |
Method to improve virus removal in protein purification
|
|
WO2011019622A1
(en)
*
|
2009-08-14 |
2011-02-17 |
Genentech, Inc. |
Cell culture methods to make antibodies with enhanced adcc function
|
|
WO2011024025A1
(en)
|
2009-08-28 |
2011-03-03 |
Avesthagen Limited |
An erythropoietin analogue and a method thereof
|
|
EP3736338A1
(en)
|
2009-09-01 |
2020-11-11 |
F. Hoffmann-La Roche AG |
Enhanced protein purification through a modified protein a elution
|
|
US9540426B2
(en)
|
2009-10-06 |
2017-01-10 |
Bristol-Myers Squibb Company |
Mammalian cell culture processes for protein production
|
|
ES2813398T3
(es)
*
|
2009-10-20 |
2021-03-23 |
Abbvie Inc |
Aislamiento y purificación de anticuerpos anti-IL-13 usando cromatografía de afinidad a Proteína A
|
|
EP2490780A4
(en)
*
|
2009-10-20 |
2014-04-09 |
Merck Sharp & Dohme |
USE OF A MIXED MODE CHROMATOGRAPHY FOR THE DETECTION AND PURIFICATION OF BASIC ANTIBODY PRODUCTS
|
|
US9096879B2
(en)
|
2009-11-24 |
2015-08-04 |
Biogen Ma Inc. |
Method of supplementing culture media to prevent undesirable amino acid substitutions
|
|
WO2011069056A2
(en)
|
2009-12-04 |
2011-06-09 |
Momenta Pharmaceuticals, Inc. |
Antennary fucosylation in glycoproteins from cho cells
|
|
US8277649B2
(en)
|
2009-12-14 |
2012-10-02 |
General Electric Company |
Membranes and associated methods for purification of antibodies
|
|
DK3272764T3
(da)
*
|
2009-12-18 |
2024-05-06 |
Novartis Ag |
Fremgangsmåde til affinitetskromatografi
|
|
KR101405463B1
(ko)
*
|
2010-01-15 |
2014-06-27 |
그래핀스퀘어 주식회사 |
기체 및 수분 차단용 그래핀 보호막, 이의 형성 방법 및 그의 용도
|
|
US8476412B2
(en)
*
|
2010-04-06 |
2013-07-02 |
Heliae Development, Llc |
Selective heated extraction of proteins from intact freshwater algal cells
|
|
CA2794697A1
(en)
|
2010-04-07 |
2011-10-13 |
Momenta Pharmaceuticals, Inc. |
High mannose glycans
|
|
PT2563904E
(pt)
|
2010-04-26 |
2015-05-12 |
Novartis Ag |
Meio de cultura de células aperfeiçoado
|
|
CA2795461C
(en)
|
2010-04-26 |
2018-04-24 |
Novartis Ag |
Improved cell cultivation process
|
|
WO2011150241A2
(en)
|
2010-05-28 |
2011-12-01 |
Genentech, Inc. |
Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase
|
|
EP2601287B1
(en)
|
2010-08-05 |
2015-01-07 |
Amgen Inc. |
Dipeptides to enhance yield and viability from cell cultures
|
|
WO2012030512A1
(en)
|
2010-09-03 |
2012-03-08 |
Percivia Llc. |
Flow-through protein purification process
|
|
CA2810909A1
(en)
*
|
2010-09-20 |
2012-03-29 |
Abbvie Inc. |
Purification of antibodies using simulated moving bed chromatography
|
|
SG10201508401TA
(en)
*
|
2010-10-11 |
2015-11-27 |
Abbvie Bahamas Ltd |
Processes for purification of proteins
|
|
EP2628797B1
(en)
|
2010-10-15 |
2016-07-13 |
JCR Pharmaceuticals CO., LTD. |
Method for producing glycoprotein having mannose residue as non-reducing end of sugar chain
|
|
EP2450375A1
(en)
|
2010-11-09 |
2012-05-09 |
Sandoz Gmbh |
Cell culture medium and process for protein expression, said medium and process comprising a PAM inhibitor
|
|
CN103429609A
(zh)
*
|
2010-12-08 |
2013-12-04 |
安姆根有限公司 |
在氨基酸存在下的离子交换层析
|
|
US20140162317A1
(en)
|
2010-12-21 |
2014-06-12 |
Roberto Falkenstein |
Isoform entriched antibody preparation and method for obtaining it
|
|
JP2014509850A
(ja)
|
2011-03-06 |
2014-04-24 |
メルク セロノ ソシエテ アノニム |
低フコース細胞株およびその使用
|
|
BR112013024521A2
(pt)
|
2011-03-25 |
2019-09-24 |
Genentech Inc |
métodos de purificação de proteínas
|
|
EP2511293A1
(en)
|
2011-04-13 |
2012-10-17 |
LEK Pharmaceuticals d.d. |
A method for controlling the main complex N-glycan structures and the acidic variants and variability in bioprocesses producing recombinant proteins
|
|
WO2012145682A1
(en)
|
2011-04-21 |
2012-10-26 |
Amgen Inc. |
A method for culturing mammalian cells to improve recombinant protein production
|
|
US9670519B2
(en)
|
2011-04-29 |
2017-06-06 |
Biocon Limited |
Methods for reducing accumulation of lactate during culturing and method for producing polypeptide
|
|
US20120283419A1
(en)
|
2011-05-03 |
2012-11-08 |
Avantor Performance Materials, Inc. |
Separation of protein monomers from aggregates by solid weak anion exchange support functionalized with amine moieties
|
|
US9562252B2
(en)
|
2011-05-13 |
2017-02-07 |
Biogen Ma Inc. |
Methods of preventing and removing trisulfide bonds
|
|
KR101662412B1
(ko)
|
2011-07-01 |
2016-10-04 |
암젠 인크 |
포유동물 세포 배양
|
|
WO2013006461A1
(en)
|
2011-07-01 |
2013-01-10 |
Biogen Idec Ma Inc. |
Cholesterol-based media supplementals for cell culture
|
|
WO2013009648A2
(en)
|
2011-07-08 |
2013-01-17 |
Momenta Pharmaceuticals, Inc. |
Cell culture process
|
|
WO2013013013A2
(en)
|
2011-07-21 |
2013-01-24 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for producing modified glycoproteins
|
|
JP6356605B2
(ja)
|
2011-10-19 |
2018-07-11 |
ロシュ グリクアート アーゲー |
フコシル化抗体の分離法
|
|
WO2013158279A1
(en)
*
|
2012-04-20 |
2013-10-24 |
Abbvie Inc. |
Protein purification methods to reduce acidic species
|
|
US9249182B2
(en)
*
|
2012-05-24 |
2016-02-02 |
Abbvie, Inc. |
Purification of antibodies using hydrophobic interaction chromatography
|
|
US9085618B2
(en)
*
|
2013-10-18 |
2015-07-21 |
Abbvie, Inc. |
Low acidic species compositions and methods for producing and using the same
|