MX2013010737A - Novedosos metodos de purificacion de proteinas. - Google Patents

Novedosos metodos de purificacion de proteinas.

Info

Publication number
MX2013010737A
MX2013010737A MX2013010737A MX2013010737A MX2013010737A MX 2013010737 A MX2013010737 A MX 2013010737A MX 2013010737 A MX2013010737 A MX 2013010737A MX 2013010737 A MX2013010737 A MX 2013010737A MX 2013010737 A MX2013010737 A MX 2013010737A
Authority
MX
Mexico
Prior art keywords
surfactant
protein purification
purification methods
novel protein
protein
Prior art date
Application number
MX2013010737A
Other languages
English (en)
Inventor
Jun Liu
Arick Brown
Junyan Ji
Yuchang John Wang
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46931857&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2013010737(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX2013010737A publication Critical patent/MX2013010737A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/02—Recovery or purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14311—Parvovirus, e.g. minute virus of mice
    • C12N2750/14351—Methods of production or purification of viral material

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Water Supply & Treatment (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención proporciona métodos para reducir incrustación de membranas de ultrafiltración en procesos en donde partículas de virus se retiran de soluciones acuosas que comprenden partículas de virus y por lo menos una proteína mediante la adición de un agente no iónico, surfactante o no surfactante a la solución acuosa antes de filtración. La invención también proporciona métodos para disociar agregados de proteína o para reducir la formación de agregados de proteína mediante la adición de un agente no iónico, surfactante o no surfactante a la solución de proteína.
MX2013010737A 2011-03-25 2012-03-23 Novedosos metodos de purificacion de proteinas. MX2013010737A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161467897P 2011-03-25 2011-03-25
PCT/US2012/030265 WO2012134987A1 (en) 2011-03-25 2012-03-23 Novel protein purification methods

Publications (1)

Publication Number Publication Date
MX2013010737A true MX2013010737A (es) 2014-03-12

Family

ID=46931857

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013010737A MX2013010737A (es) 2011-03-25 2012-03-23 Novedosos metodos de purificacion de proteinas.

Country Status (18)

Country Link
US (1) US10906934B2 (es)
EP (1) EP2697369B1 (es)
KR (1) KR20140022845A (es)
CN (1) CN103582700B (es)
AU (1) AU2012237026A1 (es)
BR (1) BR112013024521A2 (es)
CA (1) CA2830640A1 (es)
ES (1) ES2685079T3 (es)
HK (1) HK1194434A1 (es)
HR (1) HRP20181357T1 (es)
IL (1) IL228438A0 (es)
MX (1) MX2013010737A (es)
PL (1) PL2697369T3 (es)
RU (1) RU2013147609A (es)
SG (1) SG193564A1 (es)
SI (1) SI2697369T1 (es)
TR (1) TR201810703T4 (es)
WO (1) WO2012134987A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8911964B2 (en) 2006-09-13 2014-12-16 Abbvie Inc. Fed-batch method of making human anti-TNF-alpha antibody
SG10201510384UA (en) 2006-09-13 2016-01-28 Abbvie Inc Cell culture improvements
WO2010048192A2 (en) 2008-10-20 2010-04-29 Abbott Laboratories Viral inactivation during purification of antibodies
MX2011004200A (es) 2008-10-20 2011-05-24 Abbott Lab Aislamento y purificacion de anticuerpos usando la cromatografia de afinidad de proteina a.
SG193564A1 (en) 2011-03-25 2013-10-30 Genentech Inc Novel protein purification methods
US8933009B2 (en) 2013-03-12 2015-01-13 Ecolab Usa Inc. Surfactant blends for cleaning filtration membranes
CN105722523B (zh) 2013-11-15 2022-06-14 豪夫迈·罗氏有限公司 使用环保洗涤剂的病毒灭活方法
EP3187582A4 (en) * 2014-08-27 2018-03-28 Godo Shusei Co., Ltd. Lactase solution and milk using same
WO2017076553A1 (en) * 2015-11-05 2017-05-11 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Method for the separation of virus compositions including depletion and purification thereof
AU2018284707B2 (en) 2017-06-12 2021-11-11 Asahi Kasei Medical Co., Ltd. Method for filtering protein-containing liquid
AR112957A1 (es) 2017-09-29 2020-01-08 Ecolab Usa Inc Proceso de limpieza de membrana
JP7334174B2 (ja) 2018-02-14 2023-08-28 エコラボ ユーエスエー インコーポレイティド 膜からバイオフィルムおよび胞子を低減するための組成物および方法
EP3546475A1 (en) * 2018-03-27 2019-10-02 Sanofi Full flow-through process for purifying recombinant proteins
KR20220002581A (ko) 2019-05-03 2022-01-06 제넨테크, 인크. 정제 플랫폼으로부터 수득된 조성물의 효소적 가수분해 활성 속도를 감소시키는 방법
JP2023506173A (ja) * 2019-12-12 2023-02-15 ニュートリション アンド バイオサイエンシス ユーエスエー １，エルエルシー タンパク質のバイオプロセス
TW202216735A (zh) * 2020-07-10 2022-05-01 愛爾蘭商格里佛全球營運有限公司 製備包含人血漿來源的免疫球蛋白ｍ之組合物的方法及儲存穩定的液體組合物
WO2022015779A1 (en) * 2020-07-15 2022-01-20 Nutrition & Biosciences Usa 1, Llc Bioprocess with reduced fouling on surfaces
WO2022094116A1 (en) 2020-10-30 2022-05-05 Genentech, Inc. Purification platforms for obtaining pharmaceutical compositions having a reduced hydrolytic enzyme activity rate
CN115779683B (zh) * 2022-12-16 2024-03-22 康日百奥生物科技(苏州)有限公司 除病毒过滤方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4618533A (en) 1984-11-30 1986-10-21 Millipore Corporation Porous membrane having hydrophilic surface and process
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US5017292A (en) * 1990-05-10 1991-05-21 Millipore Corporation Membrane, process and system for isolating virus from solution
ES2241710T3 (es) 1991-11-25 2005-11-01 Enzon, Inc. Procedimiento para producir proteinas multivalentes de union a antigeno.
KR100378500B1 (ko) 1994-07-28 2003-05-22 밀리포어 코포레이션 복합다공성막및형성방법
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
US5888401A (en) 1996-09-16 1999-03-30 Union Camp Corporation Method and apparatus for reducing membrane fouling
US7365166B2 (en) * 1997-04-07 2008-04-29 Genentech, Inc. Anti-VEGF antibodies
US6096872A (en) 1997-10-14 2000-08-01 Ortho Diagnostic Systems, Inc. Viral clearance process
AU2001278716A1 (en) * 2000-08-10 2002-02-25 Chugai Seiyaku Kabushiki Kaisha Method of inhibiting antibody-containing solution from coagulating or becoming turbid
JP5290489B2 (ja) 2001-11-08 2013-09-18 アッヴィ・バイオセラピューティクス・インコーポレイテッド Ｉｇｇ抗体の安定な液体医薬製剤
AU2003212912A1 (en) * 2002-02-04 2003-09-02 Millipore Corporation Process for removing protein aggregates and virus from a protein solution
WO2003074566A2 (en) 2002-03-01 2003-09-12 Immunomedics, Inc. Rs7 antibodies
US6773600B2 (en) * 2002-06-14 2004-08-10 Cantocor, Inc. Use of a clathrate modifier, to promote passage of proteins during nanofiltration
US20060182740A1 (en) * 2002-06-21 2006-08-17 Biogen Idec, Inc. Buffered formulations for concentrating antibodies and methods of use thereof
EP1585964A4 (en) * 2002-08-28 2008-07-16 Introgen Therapeutics Inc CHROMATOGRAPHIC METHODS FOR PURIFYING ADENOVIRUSES
CN1890257A (zh) 2003-12-01 2007-01-03 诺和诺德医疗保健公司 液体因子ⅶ组合物的病毒过滤
AU2005229674B2 (en) 2004-11-18 2010-11-04 Kedrion Melville Inc. Low concentration solvent/detergent process of immuneglobulin with pre-treatment
GT200600031A (es) 2005-01-28 2006-08-29 Formulacion anticuerpo anti a beta
ES2317517T5 (es) 2005-04-11 2016-01-21 Crucell Holland B.V. Purificación de virus usando ultrafiltración
EP1886976A1 (en) * 2006-08-09 2008-02-13 Thermphos Trading GmbH Method of scale inhibition
US8741600B2 (en) * 2007-06-19 2014-06-03 Asahi Kasei Kabushiki Kaisha Method for separation of immunoglobulin monomers
US9056896B2 (en) * 2009-03-27 2015-06-16 Asahi Kasei Medical Co., Ltd. Method for removing viruses from high concentration monoclonal antibody solution
NZ597809A (en) * 2009-08-06 2014-05-30 Genentech Inc Method to improve virus removal in protein purification
SG193564A1 (en) 2011-03-25 2013-10-30 Genentech Inc Novel protein purification methods

Also Published As

Publication number Publication date
ES2685079T3 (es) 2018-10-05
EP2697369B1 (en) 2018-06-27
PL2697369T3 (pl) 2018-12-31
EP2697369A1 (en) 2014-02-19
IL228438A0 (en) 2013-12-31
EP2697369A4 (en) 2015-01-21
CA2830640A1 (en) 2012-10-04
SG193564A1 (en) 2013-10-30
US20140309403A1 (en) 2014-10-16
KR20140022845A (ko) 2014-02-25
SI2697369T1 (sl) 2018-10-30
HK1194434A1 (zh) 2014-10-17
TR201810703T4 (tr) 2018-08-27
HRP20181357T1 (hr) 2018-10-19
RU2013147609A (ru) 2015-04-27
CN103582700A (zh) 2014-02-12
BR112013024521A2 (pt) 2019-09-24
NZ615579A (en) 2016-09-30
AU2012237026A1 (en) 2013-10-24
WO2012134987A1 (en) 2012-10-04
CN103582700B (zh) 2016-08-17
US10906934B2 (en) 2021-02-02

Similar Documents

Publication Publication Date Title
MX2013010737A (es) Novedosos metodos de purificacion de proteinas.
MY188566A (en) Method to improve virus removal in protein purification
MX2016009672A (es) Cartuchos utiles en limpieza de soluciones de dialisis.
MX2020004603A (es) Metodos de purificacion de arn mensajero.
MX349601B (es) Remocion de virus contaminantes de preparaciones de aav.
MX2015007841A (es) Sistemas de filtración y membranas con flujo intensificado y método para su preparación.
EP4393938A3 (en) Virus purification
EA201391166A1 (ru) Способ и система обработки воды, используемой для промышленных целей
WO2015195452A3 (en) Single-pass filtration systems and processes
JOP20130186B1 (ar) تنقية الجزيئات الشبيهة بالفيروسات
PE20141386A1 (es) Sistemas de purificacion y mejoramiento del agua
CA2902321C (en) Surfactant blends for cleaning filtration membranes
IN2014DN03394A (es)
EA201290251A1 (ru) Системы и способы осмотического разделения
TW201613685A (en) Cleaning agent, cleaning liquid and cleaning method for reverse osmosis membrane
EA201990887A1 (ru) Вирусная фильтрация сред клеточных культур
JP2012021007A5 (es)
WO2011105828A3 (ko) 고다공성 중공사막 및 이의 제조방법
MX2015003648A (es) Unidad submarina de tratamiento del agua y procedimiento de limpieza de esa unidad.
CL2013001560A1 (es) Procedimiento para la separacion y recuperacion de una sal de metal alcalino purificada que comprende tratamiento de eliminacion de una sustancia inhibidora de la purificacion de una solucion acuosa de sal de metal alcalino con membrana de separacion.
MX2016004370A (es) Dispositivo y procedimiento para la purificacion de aguas grises.
MY168853A (en) Method for cleaning a filter
WO2016045601A3 (zh) 去除生物制品中细菌内毒素的试剂盒及方法
IN2015DN00540A (es)
WO2014170423A3 (en) Water filtration process