HK1206755A1 - Low acidic species compositions and methods for producing and using the same - Google Patents

Low acidic species compositions and methods for producing and using the same

Info

Publication number
HK1206755A1
HK1206755A1 HK15107319.2A HK15107319A HK1206755A1 HK 1206755 A1 HK1206755 A1 HK 1206755A1 HK 15107319 A HK15107319 A HK 15107319A HK 1206755 A1 HK1206755 A1 HK 1206755A1
Authority
HK
Hong Kong
Prior art keywords
producing
methods
same
acidic species
low acidic
Prior art date
Application number
HK15107319.2A
Other languages
Chinese (zh)
Inventor
Natarajan Ramasubramanyan
Lihua Yang
Matthew Omon Herigstad
Hong Yang
Kartik Subramanian
Xiaobei Zeng
Diane D Dong
Wen Chung Lim
Kathreen A Gifford
Zehra Kaymakcalan
Christopher Chumsae
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2013/031681 external-priority patent/WO2013158279A1/en
Priority claimed from PCT/US2013/031485 external-priority patent/WO2013158275A1/en
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of HK1206755A1 publication Critical patent/HK1206755A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
HK15107319.2A 2013-03-14 2015-07-30 Low acidic species compositions and methods for producing and using the same HK1206755A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US2013/031681 WO2013158279A1 (en) 2012-04-20 2013-03-14 Protein purification methods to reduce acidic species
PCT/US2013/031485 WO2013158275A1 (en) 2012-04-20 2013-03-14 Cell culture methods to reduce acidic species
PCT/US2013/065749 WO2014158231A1 (en) 2013-03-14 2013-10-18 Low acidic species compositions and methods for producing and using the same

Publications (1)

Publication Number Publication Date
HK1206755A1 true HK1206755A1 (en) 2016-01-15

Family

ID=49517725

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15107319.2A HK1206755A1 (en) 2013-03-14 2015-07-30 Low acidic species compositions and methods for producing and using the same

Country Status (8)

Country Link
EP (1) EP2836515A1 (en)
KR (1) KR20150129033A (en)
AU (1) AU2013384204B2 (en)
BR (1) BR112015017307A2 (en)
CA (3) CA2926301A1 (en)
HK (1) HK1206755A1 (en)
SG (1) SG11201504260UA (en)
WO (1) WO2014158231A1 (en)

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WO2013158279A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Protein purification methods to reduce acidic species
US9181572B2 (en) 2012-04-20 2015-11-10 Abbvie, Inc. Methods to modulate lysine variant distribution
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
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US9499614B2 (en) 2013-03-14 2016-11-22 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
WO2015051293A2 (en) 2013-10-04 2015-04-09 Abbvie, Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
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US11020686B2 (en) 2016-08-16 2021-06-01 Regeneron Pharmaceuticals, Inc. Methods for quantitating individual antibodies from a mixture
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CN109923411B (en) 2016-10-25 2022-05-31 里珍纳龙药品有限公司 Method and system for chromatographic data analysis
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GB201711481D0 (en) * 2017-07-17 2017-08-30 Ucb Biopharma Sprl Protein purification
TW202005694A (en) 2018-07-02 2020-02-01 美商里珍納龍藥品有限公司 Systems and methods for preparing a polypeptide from a mixture
CN111693711B (en) * 2019-03-12 2023-05-05 上海市质量监督检验技术研究院 Method for simultaneously detecting 103 antibiotic residues in fresh eggs through ultra-high pressure liquid chromatography-tandem mass spectrometry
JP2023507981A (en) * 2019-12-18 2023-02-28 テサロ， インコーポレイテッド Biopharmaceutical compositions and related methods
WO2022154762A1 (en) * 2021-01-18 2022-07-21 Turgut İlaçlari A.Ş. Method of producing adalimumab

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Also Published As

Publication number Publication date
SG11201504260UA (en) 2015-10-29
CA2926301A1 (en) 2014-10-02
KR20150129033A (en) 2015-11-18
WO2014158231A1 (en) 2014-10-02
BR112015017307A2 (en) 2017-11-21
EP2836515A1 (en) 2015-02-18
AU2013384204B2 (en) 2017-03-16
AU2013384204A1 (en) 2015-06-04
CA2899308A1 (en) 2014-10-02
CA2899308C (en) 2017-04-18
CA2926384A1 (en) 2014-10-02

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